Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome

References

• Abdul-Ghani, M. A. and DeFronzo, R. A. (2010). Pathogenesis of insulin resistance in skeletal muscle. J. Biomed. Biotechnol. 2010. DOI: 10.1155/2010/476279.
   PubMedGoogle Scholar
• Alonso-Castro, A. J., Zapata-Bustos, R., Gómez-Espinoza, G. and Salazar-Olivo, L. A. (2012). Isoorientin reverts TNF-α-induced insulin resistance in adipocytes activating the insulin signaling pathway. Endocrinology. 153:5222–5230.
   PubMed Web of Science ®Google Scholar
• Andrade-Cetto, A. and Wiedenfeld, H. (2001). Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78:145–149.
   PubMed Web of Science ®Google Scholar
• Annapurna, H. V., Apoorva, B., Ravichandran, N., Arun, K. P., Brindha, P., Swaminathan, S., Vijayalakshmi, M. and Nagarajan, A. (2013). Isolation and in silico evaluation of antidiabetic molecules of Cynodon dactylon (L.). J. Mol. Graphics Modell. 39:87–97.
   Google Scholar
• Anonymous. (2013). The labelling of rooibos and the rules of use for rooibos. Annexure, Notice 911 of 2013. The Government Gazette of South Africa. No 36820, 6 September 2013.
   Google Scholar
• Anonynous. (2014). Geographical indications from the Republic of South Africa (2014/C 51/09). Official Journal of the European Union C051, 22 February 2014.
   Google Scholar
• Beelders, T., Kalili, K. M., Joubert, E., de Beer, D. and de Villiers, A. (2012a). Comprehensive two-dimensional liquid chromatographic analysis of rooibos (Aspalathus linearis) phenolics. J. Sep. Sci. 35:1808–1820.
   PubMed Web of Science ®Google Scholar
• Beelders, T., Sigge, G. O., Joubert, E., de Beer, D. and de Villiers, A. (2012b). Kinetic optimisation of the reversed phase liquid chromatographic separation of rooibos tea (Aspalathus linearis) phenolics on conventional high performance liquid chromatographic instrumentation. J. Chromatogr. A. 1219:128–139.
   PubMed Web of Science ®Google Scholar
• Beltrán-Debón, R., Rull, A., Rodríguez-Sanabria, F., Iswaldi, I., Herranz-López, M., Aragonès, G., Camps, J., Alonso-Villaverde, C., Menéndez, J. A., Micol, V., Segura-Carretero, A. and Joven, J. (2011). Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice. Phytomedicine. 18:414–424.
   PubMed Web of Science ®Google Scholar
• Bensellam, M., Laybutt, D. R. and Jonas, J.-C. (2012). The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions. Mol. Cell. Endocrinol. 364:1–27.
   PubMed Web of Science ®Google Scholar
• Birari, R. B. and Bhutani, K. K. (2007). Pancreatic lipase inhibitors from natural sources: Unexplored potential. Drug Discov. Today. 12:879–889.
   PubMed Web of Science ®Google Scholar
• Blume, N., Skouv, J., Larsson, L. I., Holst, J. J. and Madsen, O. D. (1995). Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. J. Clin. Invest. 96:2227–2235.
   PubMed Web of Science ®Google Scholar
• Boath, A. S., Stewart, D. and McDougall, G. J. (2012). Berry components inhibit α-glucosidase in vitro: Synergies between acarbose and polyphenols from black currant and rowanberry. Food Chem. 135:929–936.
   PubMed Web of Science ®Google Scholar
• Bradley, R., Sherman, K., Catz, S., Calabrese, C., Jordan, L., Grothaus, L. and Cherkin, D. (2011). Survey of CAM interest, self-care, and satisfaction with health care for type 2 diabetes at group health cooperative. BMC Complementary Altern. Med. 11:121.
   PubMed Web of Science ®Google Scholar
• Braune, A. and Blaut, M. (2011). Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. Environ. Microbiol. 13:482–494.
   PubMed Web of Science ®Google Scholar
• Braune, A. and Blaut, M. (2012). Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glucosides. Appl. Environ. Microbiol. 78:8151–8153.
   PubMed Web of Science ®Google Scholar
• Braune, A., Gütschow, M. l., Engst, W. and Blaut, M. (2001). Degradation of quercetin and luteolin by Eubacterium ramulus. Appl. Environ. Microbiol. 67:5558–5567.
   PubMed Web of Science ®Google Scholar
• Breiter, T., Laue, C., Kressel, G., Gröll, S., Engelhardt, U. H. and Hahn, A. (2011). Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations. Food Chem. 128:338–347.
   PubMed Web of Science ®Google Scholar
• Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A. and Butler, P. C. (2003). β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes. 52:102–110.
   PubMed Web of Science ®Google Scholar
• Cai, Q., Li, B., Yu, F., Lu, W., Zhang, Z., Yin, M. and Gao, H. (2013). Investigation of the protective effects of phlorizin on diabetic cardiomyopathy in db/db mice by quantitative proteomics. J. Diabetes Res. 2013. DOI: 10.1155/2013/263845.
   Web of Science ®Google Scholar
• Chen, Y.-G., Li, P., Li, P., Yan, R., Zhang, X.-Q., Wang, Y., Zhang, X.-T., Ye, W.-C. and Zhang, Q.-W. (2013). α-Glucosidase inhibitory effect and simultaneous quantification of three major flavonoid glycosides in Microctis folium. Molecules. 18:4221–4232.
   PubMed Web of Science ®Google Scholar
• Choi, I., Park, Y., Choi, H. and Lee, E. H. (2006). Anti-adipogenic activity of rutin in 3T3-L1 cells and mice fed with high-fat diet. BioFactors. 26:273–281.
   PubMed Web of Science ®Google Scholar
• Choi, J. S., Islam, M. N., Ali, Y., Kim, E. J., Kim, Y. M. and Jung, H. A. (2014a). Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. Food. Chem. Toxicol. 64:27–33.
   PubMed Web of Science ®Google Scholar
• Choi, J. S., Islam, N., Ali, Y., Kim, Y. M., Park, H. J., Sohn, H. S. and Hyun, A. J. (2014b). The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities. Arch. Pharm. Res. 37:1354–1363.
   PubMed Web of Science ®Google Scholar
• Choo, C. Y., Sulong, N. Y., Man, F. and Wong, T. W. (2012). Vitexin and isovitexin from the leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition. J. Ethnopharmacol. 142:776–781.
   PubMed Web of Science ®Google Scholar
• Courts, F. L. and Williamson, G. (2009). The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. Mol. Nutr. Food Res. 53:1104–1111.
   PubMed Web of Science ®Google Scholar
• Courts, F. L. and Williamson, G. (2013). The occurrence, fate and biological activities of C-glycosyl flavonoids in the human diet. Crit. Rev. Food Sci. Nutr. 55:1352–1367.
   Web of Science ®Google Scholar
• Danaei, G., Finucane, M. M., Lu, Y., Singh, G. M., Cowan, M. J., Paciorek, C. J., Lin, J. K., Farzadfar, F., Khang, Y.-H., Stevens, G. A., Rao, M., Ali, M. K., Riley, L. M., Robinson, C. A. and Ezzati, M. (2011). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 378:31–40.
   PubMed Web of Science ®Google Scholar
• Daval, M., Diot-Dupuy, F., Bazin, R., Hainault, I., Viollet, B., Vaulont, S., Hajduch, E., Ferré, P. and Foufelle, F. (2005). Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J. Biol. Chem. 280:25250–25257.
   PubMed Web of Science ®Google Scholar
• Dennis, T., Fanous, M. and Mousa, S. (2009). Natural products for chemopreventive and adjunctive therapy in oncologic disease. Nutr. Cancer. 61:587–597.
   PubMed Web of Science ®Google Scholar
• Dirscherl, K., Karlstetter, M., Ebert, S., Kraus, D., Hlawatsch, J., Walczak, Y., Moehle, C., Fuchshofer, R. and Langmann, T. (2010). Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J. Neuroinflammation. 7:3.
   PubMed Web of Science ®Google Scholar
• Dirscherl, K., Karlstetter, M., Ebert, S., Kraus, D., Hlawatsch, J., Walczak, Y., Moehle, C., Fuchshofer, R. and Langmann, T. (2012). Correction: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J. Neuroinflammation. 9:118.
   Web of Science ®Google Scholar
• Dludla, P. V., Muller, C. J. F., Louw, J., Joubert, E., Salie, R., Opoku, A. R. and Johnson, R. (2014). The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine. 21:595–601.
   PubMed Web of Science ®Google Scholar
• Dong, H., Lin, W., Wu, J. and Chen, T. (2010). Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. BMC Biochem. 11:23.
   PubMed Web of Science ®Google Scholar
• Dowman, J. K., Tomlinson, J. W. and Newsome, P. N. (2010). Pathogenesis of non-alcoholic fatty liver disease. QJM Int. J. Med. 103:71–83.
   PubMed Web of Science ®Google Scholar
• Ferré, P. and Foufelle, F. (2010). Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes, Obes. Metab. 12:83–92.
   PubMed Web of Science ®Google Scholar
• Fidan, O., Aslan, M. and Mor, M. (2009). Computational evaluation of isoorientin (C-glycosyl flavone) on PPAR-gamma receptors and HMG- CoA reductase using MOE 2008.10. Planta Med. 75:PH27.
   Google Scholar
• Fraga, C. G., Galleano, M., Verstraeten, S. V. and Oteiza, P. I. (2010). Basic biochemical mechanisms behind the health benefits of polyphenols. Mol. Aspects Med. 31:435–445.
   PubMed Web of Science ®Google Scholar
• Francisco, N. M. (2010). Modulation of Postprandial Oxidative Stress by Rooibos (Aspalathus linearis) in Normolipidaemic Individuals. M. Tech thesis. Cape Peninsula University of Technology, Cape Town, South Africa.
   Google Scholar
• Fu, X. C., Wang, M. W., Li, S. P. and Wang, H. L. (2006). Anti-apoptotic effect and the mechanism of orientin on ischaemic/reperfused myocardium. J. Asian Nat. Prod. Res. 8:265–272.
   PubMed Web of Science ®Google Scholar
• Funakoshi-Tago, M., Nakamura, K., Tago, K. I., Mashino, T. and Kasahara, T. (2011). Anti-inflammatory activity of structurally related flavonoids, apigenin, luteolin and fisetin. Int. Immunopharmacol. 11:1150–1159.
   PubMed Web of Science ®Google Scholar
• Gehrmann, W., Elsner, M. and Lenzen, S. (2010). Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells. Diabetes, Obes. Metab. 12:149–158.
   PubMed Web of Science ®Google Scholar
• Georgiadi, A. and Kersten, S. (2012). Mechanisms of gene regulation by fatty acids. Adv. Nutr. 3:127–134.
   PubMed Web of Science ®Google Scholar
• Goldin, A., Beckman, J. A., Schmidt, A. M. and Creager, M. A. (2006). Advanced glycation end products. Sparking the development of diabetic vascular injury. Circulation. 114:597–605.
   PubMed Web of Science ®Google Scholar
• Grundy, S. M., Hansen, B., Smith, S. C., Cleeman, J. I., Kahn, R. A. for conference participants. (2004). Clinical management of metabolic syndrome: Report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association Conference on Scientific Issues Related to Management. Arterioscler., Thromb., Vasc. Biol. 24:e19–e24.
   PubMed Web of Science ®Google Scholar
• Gustafson, B., Gogg, S., Hedjazifar, S., Jenndahl, L., Hammarstedt, A. and Smith, U. (2009). Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am. J. Physiol. Endocrinol. Metab. 297:E999–E1003.
   PubMed Web of Science ®Google Scholar
• Ha, T. J., Lee, J. H., Lee, M.-H., Lee, B. W., Kwon, H. S., Park, C.-H., Shim, K.-B., Kim, H.-T., Baek, I.-Y. and Jang, D. S. (2012). Isolation and identification of phenolic compounds from the seeds of Perilla frutescens (L.) and their inhibitory activities against α-glucosidase and aldose reductase. Food Chem. 135:1397–1403.
   PubMed Web of Science ®Google Scholar
• Hasan, S. S., Loon, W. C. W., Ahmadi, K., Ahmed, S. I. and Bukhari, N. I. (2011). Reasons, perceived efficacy and factors associated with complementary and alternative medicine use among Malaysian patients with diabetes mellitus. Br. J. Diabetes Vasc. Dis. 11:92–98.
   Google Scholar
• Hattori, M., Shu, Y.-Z., El-Sedawy, A. I. and Namba, T. (1988). Metabolism of homoorientin by human intestinal bacteria. J. Nat. Prod. 51:874–878.
   PubMed Web of Science ®Google Scholar
• Hays, N. P., Galassetti, P. R. and Coker, R. H. (2008). Prevention and treatment of type 2 diabetes: Current role of lifestyle, natural product, and pharmacological interventions. Pharmacol. Ther. 118:181–191.
   PubMed Web of Science ®Google Scholar
• Heine, R. J. and Dekker, J. M. (2002). Beyond postprandial hyperglycaemia: Metabolic factors associated with cardiovascular disease. Diabetologia. 45:461–475.
   PubMed Web of Science ®Google Scholar
• Heinrich, T., Willenberg, I. and Glomb, M. A. (2012). Chemistry of color formation during rooibos fermentation. J. Agric. Food Chem. 60:5221–5228.
   PubMed Web of Science ®Google Scholar
• Hendricks, R. and Pool, E. J. (2010). The in vitro effects of rooibos and black tea on immune pathways. J. Immunoassay Immunochem. 31:169–180.
   PubMed Web of Science ®Google Scholar
• Hendriks, J. J. A., Alblas, J., van der Pol, S. M. A., van Tol, E. A. F., Dijkstra, C. D. and de Vries, H. E. (2004). Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. J. Exp. Med. 200:1667–1672.
   PubMed Web of Science ®Google Scholar
• Huang, M., Du Plessis, J., Du Preez, J., Hamman, J. and Viloen, A. (2008). Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium. Phytother. Res. 22:669–704.
   PubMed Web of Science ®Google Scholar
• Izumi, T., Kasai, K. and Gomi, H. (2007). Secretory vesicle docking to the plasma membrane: Molecular mechanism and functional significance. Diabetes, Obes. Metab. 9:109–117.
   PubMed Web of Science ®Google Scholar
• Jo, S.-H., Ka, E.-H., Lee, H.-S., Apostolidis, E., Jang, H.-D. and Kwon, Y.-I. (2009). Comparison of antioxidant potential and rat intestinal α-glucosidases inhibitory activities of quercetin, rutin, and isoquercetin. Int. J. Appl. Res. Nat. Prod. 2:52–60.
   Google Scholar
• Joubert, E. (1996). HPLC quantification of the dihydrochalcones, aspalathin and nothofagin in rooibos tea (Aspalathus linearis) as affected by processing. Food Chem. 55:403–411.
   Web of Science ®Google Scholar
• Joubert, E., Beelders, T., de Beer, D., Malherbe, C. J., de Villiers, A. J. and Sigge, G. O. (2012). Variation in phenolic content and antioxidant activity of fermented rooibos herbal tea infusions: Role of production season and quality grade. J. Agric. Food Chem. 60:9171–9179.
   PubMed Web of Science ®Google Scholar
• Joubert, E. and de Beer, D. (2011). Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical. S. Afr. J. Bot. 77:869–886.
   Web of Science ®Google Scholar
• Joubert, E. and de Beer, D. (2012). Phenolic content and antioxidant activity of rooibos food ingredient extracts. J. Food Comp. Anal. 27:45–51.
   Web of Science ®Google Scholar
• Joubert, E., de Beer, D., Malherbe, C. J., Muller, N., Bonnet, S. L., van der Westhuizen, J. H. and Ferreira, D. (2013). Occurrence and sensory perception of Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in rooibos (Aspalathus linearis). Food Chem. 136:1078–1085.
   PubMed Web of Science ®Google Scholar
• Joubert, E., Gelderblom, W. C. A., Louw, A. and de Beer, D. (2008). South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides—A review. J. Ethnopharmacol. 119:376–412.
   PubMed Web of Science ®Google Scholar
• Joubert, E., Winterton, P., Britz, T. J. and Ferreira, D. (2004). Superoxide anion and α, α-diphenyl-β-picrylhydrazyl radical scavenging capacity of rooibos (Aspalathus linearis0) aqueous extracts, crude phenolic fractions, tannin and flavonoids. Food Res. Int. 37:133–138.
   Web of Science ®Google Scholar
• Joubert, J., Norman, R., Bradshaw, D., Goedecke, J. H., Steyn, N. P., Puoane, T. and South African Comparative Risk Assessment Collaborating Group. (2007). Estimating the burden of disease attributable to excess body weight in South Africa in 2000. S. Afr. Med. J. 97:683–690.
   PubMed Web of Science ®Google Scholar
• Kahn, S. E., Cooper, M. E. and Del Prato, S. (2014). Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present and future. Lancet. 383:1068–1083.
   PubMed Web of Science ®Google Scholar
• Kahn, S. E., Hull, R. L. and Utzschneider, K. M. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 444:840–846.
   PubMed Web of Science ®Google Scholar
• Kamakura, R., Son, M. J., de Beer, D., Joubert, E., Miura, Y. and Yagasaki, K. (2015). Antidiabetic effect of green rooibos (Aspalathus linearis) extract in cultured cells and type 2 diabetic model KK-Ay mice. Cytotechnology. 67:699–710.
   PubMed Web of Science ®Google Scholar
• Kawano, A., Nakamura, H., Hata, S., Minakawa, M., Miura, Y. and Yagasaki, K. (2009). Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine. 16:437–443.
   PubMed Web of Science ®Google Scholar
• Khan, A.-U. and Gilani, A. H. (2006). Selective bronchodilatory effect of Rooibos tea (Aspalathus linearis) and its flavonoid, chrysoeriol. Eur. J. Nutr. 45:463–469.
   PubMed Web of Science ®Google Scholar
• Kim, E. K., Kwon, K. B., Song, M. Y., Han, M. J., Lee, J. H., Lee, Y. R., Lee, J. H., Ryu, D. G., Park, B. H. and Park, J. W. (2007). Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor κB activation. Pancreas. 35:e1–9.
   PubMed Web of Science ®Google Scholar
• Kim, J.-S., Kwon, C.-S. and Son, K. H. (2000). Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem. 64:2458–2461.
   PubMed Web of Science ®Google Scholar
• Kim, J., Lee, I., Seo, J., Jung, M., Kim, Y., Yim, N. and Bae, K. (2010). Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells. Phytother. Res. 24:1543–1548.
   PubMed Web of Science ®Google Scholar
• Kim, M., Lee, J. and Han, J. (2014). Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. J. Sci. Food Agric. 95:1925–1931.
   PubMed Web of Science ®Google Scholar
• Koch, I. S., Muller, N., de Beer, D., Næs, T. and Joubert, E. (2013). Impact of steam pasteurization on the sensory profile and phenolic composition of rooibos (Aspalathus linearis) herbal tea infusions. Food Res. Int. 53:704–712.
   Web of Science ®Google Scholar
• Koeppen, B. H. and Roux, D. G. (1965). Aspalathin: A novel C-glycosylflavonoid from Aspalathus linearis. Tetrahedron Lett. 6:3497–3503.
   Google Scholar
• Krafczyk, N. and Glomb, M. A. (2008). Characterization of phenolic compounds in rooibos tea. J. Agric. Food Chem. 56:3368–3376.
   PubMed Web of Science ®Google Scholar
• Krafczyk, N., Heinrich, T., Porzel, A. and Glomb, M. A. (2009a). Oxidation of the dihydrochalcone aspalathin leads to dimerization. J. Agric. Food Chem. 57:6838–6843.
   PubMed Web of Science ®Google Scholar
• Krafczyk, N., Woyand, F. and Glomb, M. A. (2009b). Structure–antioxidant relationship of flavonoids from fermented rooibos. Mol. Nutr. Food Res. 53:635–642.
   PubMed Web of Science ®Google Scholar
• Kreuz, S., Joubert, E., Waldmann, K.-H. and Ternes, W. (2008). Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutr. Res. 28:690–701.
   PubMed Web of Science ®Google Scholar
• Kumar, S., Narwal, S., Kumar, V. and Prakash, O. (2011). α-Glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacogn. Rev. 5:19–29.
   PubMedGoogle Scholar
• Kunishiro, K., Tai, A. and Yamamoto, I. (2001). Effects of rooibos tea extract on antigen-specific antibody production and cytokine generation in vitro and in vivo. Biosci. Biotechnol. Biochem. 65:2137–2145.
   PubMed Web of Science ®Google Scholar
• Kuo, S. M. (2002). Flavonoids and gene expression in mammalian cells. Adv. Exp. Med. Biol. 505:191–200.
   PubMed Web of Science ®Google Scholar
• Lee, E. M., Lee, S. S., Chung, B. Y., Cho, J.-Y., Lee, I. C., Ahn, S. R., Jang, S. J. and Kim, T. H. (2010). Pancreatic lipase inhibition by C-glycosidic flavones isolated from Eremochloa ophiuroides. Molecules. 15:8251–8259.
   PubMed Web of Science ®Google Scholar
• Lee, W. and Bae, J.-P. (2015). Anti-inflammatory effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in vitro and in vivo. Inflammation. 38:1502–1516.
   PubMed Web of Science ®Google Scholar
• Lee, Y.-H., Yang, S.-H., Chen, S.-L., Pan, Y.-F., Liu, C.-M., Li, M.-W., Chou, S. S., Chou, M.-Y. and Youn, S.-C. (2014). The anti-adipogenic effect of vitexin is via ERK 1/2 MAPK signaling in 3T3-L1 adipocytes. Int. J. Pharmacol. 6:206–214.
   Google Scholar
• Li, D., Wang, Q., Yuan, Z., Zhang, L., Xu, L., Cui, Y. and Duan, K. (2008). Pharmacokinetics and tissue distribution study of orientin in rat by liquid chromatography. J. Pharmaceut. Biomed. Anal. 47:429–434.
   PubMed Web of Science ®Google Scholar
• Li, H., Song, F., Xing, J., Tsao, R., Liu, Z. and Liu, S. (2009a). Screening and structural characterization of α-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MSn and SORI-CID FTICR MS. J. Am Soc. Mass Spectrom. 20:1496–1503.
   PubMed Web of Science ®Google Scholar
• Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, John Y. J., Gao, B., Wierzbicki, M., Verbeuren, Tony J., Shaw, Reuben J., Cohen, Richard A. and Zang, M. (2011). AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13:376–388.
   PubMed Web of Science ®Google Scholar
• Li, Y. Q., Zhou, F. C., Gao, F., Bian, J. S. and Shan, F. (2009b). Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of α-glucosidase. J. Agric. Food Chem. 57:11463–11468.
   PubMed Web of Science ®Google Scholar
• Lipinski, C. A., Lombardo, F., Dominy, B. W. and Feeney, P. J. (1997). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery Rev. 23:3–35.
   Web of Science ®Google Scholar
• Liu, J.-F., Ma, Y., Wang, Y., Du, Z.-Y., Shen, J.-K. and Peng, H.-L. (2011). Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress. Phytother. Res. 25:588–596.
   PubMed Web of Science ®Google Scholar
• Lu, N., Sun, Y. and Zheng, X. (2011). Orientin-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition. Planta Med. 77:984–991.
   PubMed Web of Science ®Google Scholar
• Malviya, N., Jain, S. and Malviya, S. (2010). Antidiabetic potential of medicinal plants. Acta Pol. Pharm. 67:113–118.
   PubMed Web of Science ®Google Scholar
• Manach, C., Williamson, G., Morand, C., Scalbert, A. and Rémésy, C. (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 81:230S–242S.
   PubMed Web of Science ®Google Scholar
• Manley, M., Joubert, E. and Botha, M. (2006). Quantification of the major phenolic compounds, soluble solid content and total antioxidant activity of green rooibos (Aspalathus linearis) by means of near infrared spectroscopy. J. Near Infrared Spectrosc. 14:213–222.
   Web of Science ®Google Scholar
• Mansukhani, R., Volino, L. and Varghese, R. (2014). Natural products for the treatment of type 2 diabetes mellitus. Pharmacol. Pharm. 5:487–503.
   Google Scholar
• Marais, C., Janse van Rensburg, W., Ferreira, D. and Steenkamp, J. A. (2000). (S)- and (R)-Eriodictyol-6-C-ß-D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis). Phytochemistry. 55:43–49.
   PubMed Web of Science ®Google Scholar
• Marais, C., Steenkamp, J. A. and Ferreira, D. (1996). Occurrence of phenylpyruvic acid in woody plants: Biosynthetic significance and synthesis of an enolic glucoside derivative. J. Chem. Soc., Perkin Trans. 1:2915–2918.
   Google Scholar
• Marais, S. S., Marais, C., Steenkamp, J. A., Malan, E. and Ferreira, D. (1998). Progress in the investigation of rooibos tea extractives. In: Abstracts of the 3rd Tannin Conference, Bend, Oregon, USA, pp. 129–130.
   Google Scholar
• Marnewick, J. L., Rautenbach, F., Venter, I., Neethling, H., Blackhurst, D. M., Wolmarans, P. and Macharia, M. (2011). Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease. J. Ethnopharmacol. 133:46–52.
   PubMed Web of Science ®Google Scholar
• Mathijs, I., Da Cunha, D. A., Himpe, E., Ladriere, L., Chellan, N., Roux, C. R., Joubert, E., Muller, C., Cnop, M., Louw, J. and Bouwens, L. (2014). Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis. Mol. Nutr. Food Res. 58:1980–1990.
   PubMed Web of Science ®Google Scholar
• Matsui, T., Kobayashi, M., Hayashida, S. and Matsumoto, K. (2002). Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action. Biosci. Biotechnol. Biochem. 66:689–692.
   PubMed Web of Science ®Google Scholar
• Mazibuko, S. E., Joubert, E., Johnson, R., Louw, J., Opoku, A. R. and Muller, C. J. F. (2015). Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate. Mol. Nutr. Food Res. 59:2199–2208.
   PubMed Web of Science ®Google Scholar
• Mazibuko, S. E., Muller, C. J. F., Joubert, E., de Beer, D., Johnson, R., Opoku, A. R. and Louw, J. (2013). Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis). Phytomedicine. 20:813–819.
   PubMed Web of Science ®Google Scholar
• Memon, R. A., Feingold, K. R., Moser, A. H., Fuller, J. and Grunfeld, C. (1998). Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines. Am. J. Physiol. Endocrinol. Metab. 274:E210–E217.
   PubMed Web of Science ®Google Scholar
• Miranda, P. J., DeFronzo, R. A., Califf, R. M. and Guyton, J. R. (2005). Metabolic syndrome: Evaluation of pathological and therapeutic outcomes. Am. Heart J. 149:20–32.
   PubMed Web of Science ®Google Scholar
• Montane, J., Cadavez, L. and Novials, A. (2014). Stress and the inflammatory process: A major cause of pancreatic cell death in type 2 diabetes. Diabetes, Metab. Syndr. Obes.: Targets Ther. 7:25–34.
   PubMedGoogle Scholar
• Mueller, M., Hobiger, S. and Jungbauer, A. (2010). Anti-inflammatory activity of extracts from fruits, herbs and spices. Food Chem. 122:987–996.
   Web of Science ®Google Scholar
• Mueller, M. and Jungbauer, A. (2009). Culinary plants, herbs and spices – A rich source of PPARγ ligands. Food Chem. 117:660–667.
   Web of Science ®Google Scholar
• Muller, C. J. F., Joubert, E., de Beer, D., Sanderson, M., Malherbe, C. J., Fey, S. J. and Louw, J. (2012). Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine. 20:32–39.
   PubMed Web of Science ®Google Scholar
• Muller, C. J. F., Joubert, E., Pheiffer, C., Ghoor, S., Sanderson, M., Chellan, N., Fey, S. J. and Louw, J. (2013). Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid, an α-hydroxy acid from rooibos (Aspalathus linearis) with hypoglycemic activity. Mol. Nutr. Food Res. 57:2216–2222.
   PubMed Web of Science ®Google Scholar
• Must, A., Spadano, J., Coakley, E. H., Field, A. E., Colditz, G. and Dietz, W. H. (1999). The disease burden associated with overweight and obesity. JAMA. 282:1523–1529.
   PubMed Web of Science ®Google Scholar
• Nakamura, K. T. N., Jin, J.-S., Ma, C.-M., Komatsu, K., Iwashima, M. and Hattori, M. (2011). The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. Chem. Pharm. Bull. 59:23–27.
   PubMed Web of Science ®Google Scholar
• Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., Abraham, J. P., Abu-Rmeileh, N. M. E., Achoki, T., AlBuhairan, F. S., Alemu, Z. A., Alfonso, R., Ali, M. K., Ali, R., Guzman, N. A., Ammar, W., Anwari, P., Banerjee, A., Barquera, S., Basu, S., Bennett, D. A., Bhutta, Z., Blore, J., Cabral, N., Nonato, I. C., Chang, J.-C., Chowdhury, R., Courville, K. J., Criqui, M. H., Cundiff, D. K., Dabhadkar, K. C., Dandona, L., Davis, A., Dayama, A., Dharmaratne, S. D., Ding, E. L., Durrani, A. M., Esteghamati, A., Farzadfar, F., Fay, D. F. J., Feigin, V. L., Flaxman, A., Forouzanfar, M. H., Goto, A., Green, M. A., Gupta, R., Hafezi-Nejad, N., Hankey, G. J., Harewood, H. C., Havmoeller, R., Hay, S., Hernandez, L., Husseini, A., Idrisov, B. T., Ikeda, N., Islami, F., Jahangir, E., Jassal, S. K., Jee, S. H., Jeffreys, M., Jonas, J. B., Kabagambe, E. K., Khalifa, S. E. A. H., Kengne, A. P., Khader, Y. S., Khang, Y.-H., Kim, D., Kimokoti, R. W., Kinge, J. M., Kokubo, Y., Kosen, S., Kwan, G., Lai, T., Leinsalu, M., Li, Y., Liang, X., Liu, S., Logroscino, G., Lotufo, P. A., Lu, Y., Ma, J., Mainoo, N. K., Mensah, G. A., Merriman, T. R., Mokdad, A. H., Moschandreas, J., Naghavi, M., Naheed, A., Nand, D., Narayan, K. M. V., Nelson, E. L., Neuhouser, M. L., Nisar, M. I., Ohkubo, T., Oti, S. O., Pedroza, A., Prabhakaran, D., Roy, N., Sampson, U., Seo, H., Sepanlou, S. G., Shibuya, K., Shiri, R., Shiue, I., Singh, G. M., Singh, J. A., Skirbekk, V., Stapelberg, N. J. C., Sturua, L., Sykes, B. L., Tobias, M., Tran, B. X., Trasande, L., Toyoshima, H., van de Vijver, S., Vasankari, T. J., Veerman, J. L., Velasquez-Melendez, G., Vlassov, V. V., Vollset, S. E., Vos, T., Wang, C., Wang, X., Weiderpass, E., Werdecker, A., Wright, J. L., Yang, Y. C., Yatsuya, H., Yoon, J., Yoon, S.-J., Zhao, Y., Zhou, M., Zhu, S., Lopez, A. D., Murray, C. J. L. and Gakidou, E. (2014). Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 384:766–781.
   PubMed Web of Science ®Google Scholar
• Oki, T., Matsui, T. and Matsumoto, K. (2000). Evaluation of α-glucosidase inhibition by using an immobilized assay system. Biol. Pharm. Bull. 23:1084–1087.
   PubMed Web of Science ®Google Scholar
• Oki, T., Matsui, T. and Osajima, Y. (1999). Inhibitory effect of α-glucosidase inhibitors varies according to its origin. J. Agric. Food Chem. 47:550–553.
   PubMed Web of Science ®Google Scholar
• Park, C. M. and Song, Y.-S. (2013). Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells. Nutr. Res. Pract. 7:423–429.
   PubMed Web of Science ®Google Scholar
• Patwardhan, B. and Mashelkar, R. A. (2009). Traditional medicine-inspired approaches to drug discovery: Can Ayurveda show the way forward? Drug Discov. Today. 14:804–811.
   PubMed Web of Science ®Google Scholar
• Peer, N., Steyn, K., Lombard, C., Lambert, E. V., Vythilingum, B. and Levitt, N. S. (2012). Rising diabetes prevalence among urban-dwelling black South Africans. PLoS ONE. 7:e43336.
   PubMed Web of Science ®Google Scholar
• Persson, I. A. L. (2012). The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, rooibos and enalaprilat—A study on enzyme kinetics. Phytother. Res. 26:517–521.
   PubMed Web of Science ®Google Scholar
• Persson, I. A. L., Josefsson, M., Persson, K. and Andersson, R. G. G. (2006). Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells. J. Pharm. Pharmacol. 58:1139–1144.
   PubMed Web of Science ®Google Scholar
• Persson, I. A. L., Persson, K., Hägg, S. and Anderson, R. G. G. (2010). Effects of green tea, black tea and Rooibos tea on angiotensin converting enzyme and nitric oxide in healthy volunteers. Publ. Health Nutr,. 13:730–737.
   PubMed Web of Science ®Google Scholar
• Peters, S. E., Huxley, R. and Woodward, M. (2014). Diabetes as risk factor for incident coronary heart disease in women compared with men: A systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 57:1542–1551.
   PubMed Web of Science ®Google Scholar
• Petersen, K. F., Dufour, S., Befroy, D., Garcia, R. and Shulman, G. I. (2004). Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350:664–671.
   PubMed Web of Science ®Google Scholar
• Pinent, M., Castell, A., Baiges, I., Montagut, G., Arola, L. and Ardévol, A. (2008). Bioactivity of flavonoids on insulin-secreting cells. Comp. Rev. Food Sci. Food Saf. 7:299–308.
   PubMed Web of Science ®Google Scholar
• Potterat, O. and Hamburger, M. (2013). Concepts and technologies for tracking bioactive compounds in natural product extracts: Generation of libraries, and hyphenation of analytical processes with bioassays. Nat. Prod. Rep. 30:546–564.
   PubMed Web of Science ®Google Scholar
• Rasmussen, B. B., Holmbäck, U. C., Volpi, E., Morio-Liondore, B., Paddon-Jones, D. and Wolfe, R. R. (2002). Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J. Clin. Invest. 110:1687–1693.
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw, S., Nihal, M. and Ahmad, N. (2008). Dose translation from animal to human studies revisited. FASEB J. 22:659–661.
   PubMed Web of Science ®Google Scholar
• Reaven, G. (2005). Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: The price paid to maintain glucose homeostasis in insulin-resistant individuals. Endocrinol. Metab. Clin. North Am. 34:49–62.
   PubMed Web of Science ®Google Scholar
• Rein, M. J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S. K. and Da Silva Pinto, M. (2012). Bioavailability of food components: A challenging journey to bioefficacy. Br. J. Clin. Pharmacol. 75:588–602.
   Web of Science ®Google Scholar
• Rosen, E. D. and MacDougald, O. A. (2006). Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7:885–896.
   PubMed Web of Science ®Google Scholar
• Ruiz, P. A. and Haller, D. (2006). Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells. J. Nutr. 136:664–671.
   PubMed Web of Science ®Google Scholar
• Sanderson, M., Mazibuko, S. E., Joubert, E., de Beer, D., Johnson, R., Pheiffer, C., Louw, J. and Muller, C. J. F. (2014). Effects of fermented rooibos (Aspalathus linearis) on adipocyte differentiation. Phytomedicine. 21:109–117.
   PubMed Web of Science ®Google Scholar
• Sangul, K., Akao, T., Li, Y., Kakiuchi, N., Nakamura, N. and Hattori, M. (2005). Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond. Biol. Pharm. Bull. 28:1672–1678.
   PubMed Web of Science ®Google Scholar
• Scheen, A. J. (2003). Is there a role for α-glucosidase inhibitors in the prevention of type 2 diabetes mellitus? Drugs. 63:933–951.
   PubMed Web of Science ®Google Scholar
• Schloms, L., Storbeck, K.-H., Swart, P., Gelderblom, W. C. A. and Swart, A. C. (2012). The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells. J. Steroid Biochem. Mol. Biol. 128:128–138.
   PubMed Web of Science ®Google Scholar
• Schoefer, L., Mohan, R., Schwiertz, A., Braune, A. and Blaut, M. (2003). Anaerobic degradation of flavonoids by Clostridium orbiscindens. Appl. Environ. Microbiol. 69:5849–5854.
   PubMed Web of Science ®Google Scholar
• Semplicini, A., Ceolotto, G., Massimino, M., Valle, R., Serena, L., De Toni, R., Pessina, A. C. and Dal Palù, C. (1994). Interactions between insulin and sodium homeostasis in essential hypertension. Am. J. Med. Sci. 307:S43–S46.
   PubMed Web of Science ®Google Scholar
• Sezik, E., Aslan, M., Yesilada, E. and Ito, S. (2005). Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci. 76:1223–1238.
   PubMed Web of Science ®Google Scholar
• Shaw, J. E., Sicree, R. A. and Zimmet, P. Z. (2009). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87:4–14.
   PubMed Web of Science ®Google Scholar
• Silveira, L. R., Fiamoncini, J., Hirabara, S. M., Procópio, J., Cambiaghi, T. D., Pinheiro, C. H., Lopes, L. R. and Curi, R. (2008). Updating the effects of fatty acids on skeletal muscle. J. Cell. Physiol. 217:1–12.
   PubMed Web of Science ®Google Scholar
• Sirikul, B., Gower, B. A., Hunter, G. R., Larson-Meyer, D. E. and Newcomer, B. R. (2006). Relationship between insulin sensitivity and in vivo mitochondrial function in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 294:E724–E728.
   Web of Science ®Google Scholar
• Snel, M., Jonker, J. T., Hammer, S., Kerpershoek, G., Lamb, H. J., Meinders, A. E., Pijl, H., de Roos, A., Romijn, J. A., Smit, J. W. A. and Jazet, I. M. (2012). Long-term beneficial effect of a 16-week very low calorie diet on pericardial fat in obese type 2 diabetes mellitus patients. Obesity. 20:1572–1576.
   PubMed Web of Science ®Google Scholar
• Snijman, P. W., Joubert, E., Ferreira, D., Li, X.-C., Ding, Y., Green, I. R. and Gelderblom, W. C. A. (2009). Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) flavonoids, epigallocatechin gallate, and trolox. J. Agric. Food Chem. 57:6678–6684.
   PubMed Web of Science ®Google Scholar
• Son, M. J., Minakawa, M., Miura, Y. and Yagasaki, K. (2013). Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice. Eur. J. Nutr. 52:1607–1619.
   PubMed Web of Science ®Google Scholar
• South African Rooibos Council (2013). Available at https://sarooibos.co.za.
   Google Scholar
• Stalmach, A., Mullen, W., Pecorari, M., Serafini, M. and Crozier, A. (2009). Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. J. Agric. Food Chem. 57:7104–7111.
   PubMed Web of Science ®Google Scholar
• Sun, D., Huang, J., Zhang, Z., Gao, H., Li, J., Shen, M., Cao, F. and Wang, H. (2012). Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats. PLoS ONE. 7:e33491.
   PubMed Web of Science ®Google Scholar
• Sun, K., Kusminski, C. M. and Scherer, P. E. (2011). Adipose tissue remodeling and obesity. J. Clin. Invest. 121:2094–2101.
   PubMed Web of Science ®Google Scholar
• Thielecke, F. and Boschmann, M. (2009). The potential role of green tea catechins in the prevention of the metabolic syndrome - a review. Phytochemistry. 70:11–24.
   PubMed Web of Science ®Google Scholar
• Tiwari, A. K. and Rao, J. M. (2002). Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Curr. Sci. 83:30–38.
   Web of Science ®Google Scholar
• Tucci, S. A., Boyland, E. J. and Halford, J. C. G. (2010). The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: A review of current and emerging therapeutic agents. Diabetes, Metab. Syndr. Obes.: Targets Ther. 3:125–143.
   PubMedGoogle Scholar
• Ulicná, O., Vancová, O., Bozek, P., Cársky, J., Sebeková, K., Boor, P., Nakano, M. and Greksák, M. (2006). Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats. Physiol. Res. 55:157–164.
   PubMed Web of Science ®Google Scholar
• Van de Laar, F. A., Lucassen, P. L., Akkermans, R. P., van de Lisdonk, E. H., Rutten, G. E. and van Weel, C. (2005). α-Glucosidase inhibitors for patients with type 2 diabetes. Results from a Cochrane systematic review and meta-analysis. Diabetes Care. 28:154–163.
   PubMed Web of Science ®Google Scholar
• Van de Laar, F. A., Lucassen, P. L. B. J., Akkermans, R. P., Van de Lisdonk, E. H. and De Grauw, W. J. C. (2006). Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database Syst. Rev. doi: 10.1002/14651858.CD005061.pub2.
   PubMed Web of Science ®Google Scholar
• Van der Merwe, J. D., Joubert, E., Manley, M., De Beer, D., Malherbe, C. J. and Gelderblom, W. C. A. (2010). In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity. J. Agric. Food Chem. 58:2214–2220.
   PubMed Web of Science ®Google Scholar
• Veber, D. F., Johnson, S. R., Cheng, H. Y., Smith, B. R., Ward, K. W. and Kopple, K. D. (2002). Molecular properties that influences the oral bioavailability of drug candidates. J. Med. Chem. 45:2615–2623.
   PubMed Web of Science ®Google Scholar
• Von Gadow, A., Joubert, E. and Hansmann, C. F. (1997). Comparison of the antioxidant activity of aspalathin with that of other plant phenols of rooibos tea (Aspalathus linearis), α-tocopherol, BHT, and BHA. J. Agric. Food Chem. 45:632–638.
   Web of Science ®Google Scholar
• Wedler, J., Daubitz, T., Schlotterbeck, G. and Butterweck, V. (2014). In vitro anti-inflammatory and wound-healing potential of a Phyllostachys edulis leaf extract – Identification of isoorientin as an active compound. Planta Med. 80:1678–1684.
   PubMed Web of Science ®Google Scholar
• WHO. (2012). Global status report on noncommunicable diseases 2010.
   Google Scholar
• WHO. (2015). Obesity and overweight. Fact sheet N° 311.
   Google Scholar
• Williams, R. J., Spencer, J. P. E. and Rice-Evans, C. (2004). Flavonoids: Antioxidants or signalling molecules? Free Radical Biol. Med. 36:838–849.
   PubMed Web of Science ®Google Scholar
• Wolfram, S., Wang, Y. and Thielecke, F. (2006). Anti-obesity effects of green tea: From bedside to bench. Mol. Nutr. Food Res. 50:176–187.
   PubMed Web of Science ®Google Scholar
• Wu, X., Xu, T., Li, D., Zhu, S., Chen, Q., Hu, W., Pan, D., Zhu, H. and Sun, H. (2013). ERK/PP1a/PLB/SERCA2a and JNK pathways are involved in luteolin-mediated protection of rat hearts and cardiomyocytes following ischemia/reperfusion. PLoS ONE. 8:e82957.
   PubMed Web of Science ®Google Scholar
• Xiao, J., Kai, G., Yamamoto, K. and Chen, X. (2012). Advance in dietary polyphenols as α-glucosidases inhibitors: A review on structure-activity relationship aspect. Crit. Rev. Food Sci. Nutr. 53:818–836.
   Web of Science ®Google Scholar
• Yao, L., Herlea-Pana, O., Heuser-Baker, J., Chen, Y. and Barlic-Dicen, J. (2014). Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease. J. Immunol. Res. doi: 10.1155/2014/181450.
   Web of Science ®Google Scholar
• Yao, Y., Cheng, X., Wang, L., Wang, S. and Ren, G. (2011). A determination of potential α-glucosidase inhibitors from azuki beans (Vigna angularis). Int. J. Mol. Sci. 12:6445–6451.
   PubMed Web of Science ®Google Scholar
• Yun, J. W. (2010). Possible anti-obesity therapeutics from nature—A review. Phytochemistry. 71:1625–1641.
   PubMed Web of Science ®Google Scholar
• Zammit, V. A. (2008). Carnitine palmitoyltransferase 1: Central to cell function. IUBMB Life. 60:347–354.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Xiaowei, T., Bili, B., Xiaoqin, W. and Ying, Z. (2007). Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats. Br. J. Nutr. 97:484–494.
   PubMed Web of Science ®Google Scholar
• Zhou, H., Danger, D. P., Dock, S. T., Hawley, L., Roller, S. G., Smith, C. D. and Handlon, A. L. (2010). Synthesis and SAR of benzisothiazole- and indolizine-β-D-glucopyranoside inhibitors of SGLT2. ACS Med. Chem. Lett. 1:19–23.
   PubMed Web of Science ®Google Scholar
• Zimmet, P., Magliano, D., Matsuzawa, Y., Alberti, G. and Shaw, J. (2005). The metabolic syndrome: A global public health problem and a new definition. J. Atheroscler. Thromb. 12:295–300.
   PubMed Web of Science ®Google Scholar