The more effective treatment of atrial fibrillation applying the natural compounds; as NADPH oxidase and ion channel inhibitors

References

• Adam, O., G. Frost, F. Custodis, M. A. Sussman, H.-J. Schäfers, M. Böhm, and U. Laufs 2007. Role of Rac1 GTPase activation in atrial fibrillation. Journal of the American College of Cardiology 50:359–67.
   PubMed Web of Science ®Google Scholar
• Ago, T., J. Kuroda, J. Pain, C. Fu, H. Li, and J. Sadoshima 2010. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circulation Research 106:1253–64.
   PubMed Web of Science ®Google Scholar
• Ahmed, T., M. Abdollahi, M. Daglia, S. F. Nabavi, and S. M. Nabavi 2015. Berberine and neurodegeneration: A review of literature. Pharmacological Reports 67:970–79.
   PubMed Web of Science ®Google Scholar
• Alamolhodaei, N. S., A. M. Tsatsakis, M. Ramezani, A. W. Hayes, and G. Karimi 2017. Resveratrol as MDR reversion molecule in breast cancer: An overview. Food and Chemical Toxicology 103:223–32.
   PubMed Web of Science ®Google Scholar
• Aldieri, E., C. Riganti, M. Polimeni, E. Gazzano, C. Lussiana, I. Campia, and D. Ghigo 2008. Classical inhibitors of NOX NAD (P) H oxidases are not specific. Current Drug Metabolism 9:686–96.
   PubMed Web of Science ®Google Scholar
• Anatoliotakis, N., S. Deftereos, G. Bouras, G. Giannopoulos, D. Tsounis, C. Angelidis, A. Kaoukis, and C. Stefanadis 2013. Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular disease. Current Topics in Medicinal Chemistry 13:115–38.
   PubMed Web of Science ®Google Scholar
• Antoniades, C., M. Demosthenous, S. Reilly, M. Margaritis, M.-H. Zhang, A. Antonopoulos, K. Marinou, K. Nahar, R. Jayaram, and D. Tousoulis 2012. Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery: Effects of short-term pre-operative statin treatment. Journal of the American College of Cardiology 59:60–70.
   PubMed Web of Science ®Google Scholar
• Babusikova, E., P. Kaplan, J. Lehotsky, M. Jesenak, and D. Dobrota 2004. Oxidative modification of rat cardiac mitochondrial membranes and myofibrils by hydroxyl radicals. General Physiology and Biophysics 23:327–36.
   PubMed Web of Science ®Google Scholar
• Baczkó, I., and P. E. Light 2015. Resveratrol and derivatives for the treatment of atrial fibrillation. Annals of the New York Academy of Sciences 1348:68–74.
   PubMed Web of Science ®Google Scholar
• Bendall, J. K., A. C. Cave, C. Heymes, N. Gall, and A. M. Shah 2002. Pivotal role of a gp91phox-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation 105:293–96.
   PubMed Web of Science ®Google Scholar
• Beswick, R. A., A. M. Dorrance, R. Leite, and R. C. Webb 2001. NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat. Hypertension 38:1107–11.
   PubMed Web of Science ®Google Scholar
• Boillée, S., and D. W. Cleveland 2008. Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. The Journal of Clinical Investigation 118:474–78.
   PubMed Web of Science ®Google Scholar
• Boonla, O., U. Kukongviriyapan, P. Pakdeechote, V. Kukongviriyapan, P. Pannangpetch, P. Prachaney, and S. E. Greenwald 2014. Curcumin improves endothelial dysfunction and vascular remodeling in 2K-1C hypertensive rats by raising nitric oxide availability and reducing oxidative stress. Nitric Oxide 42:44–53.
   PubMed Web of Science ®Google Scholar
• Bradamante, S., L. Barenghi, and A. Villa 2004. Cardiovascular protective effects of resveratrol. Cardiovascular Therapeutics 22:169–88.
   Google Scholar
• Chan, A. Y., V. W. Dolinsky, C.-L. M. Soltys, B. Viollet, S. Baksh, P. E. Light, and J. R. Dyck 2008. Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. Journal of Biological Chemistry 283:24194–201.
   PubMed Web of Science ®Google Scholar
• Chang, J.-P., M.-C. Chen, W.-H. Liu, C.-H. Yang, C.-J. Chen, Y.-L. Chen, K.-L. Pan, T.-H. Tsai, and H.-W. Chang 2011. Atrial myocardial nox2 containing NADPH oxidase activity contribution to oxidative stress in mitral regurgitation: potential mechanism for atrial remodeling. Cardiovascular Pathology 20:99–106.
   PubMed Web of Science ®Google Scholar
• Chen, Q.-Z., W.-Q. Han, J. Chen, D.-L. Zhu, and P.-J. Gao 2013. Anti-stiffness effect of apocynin in deoxycorticosterone acetate-salt hypertensive rats via inhibition of oxidative stress. Hypertension Research 36:306–12.
   PubMed Web of Science ®Google Scholar
• Chen, W. P., L. M. Hung, C. H. Hsueh, L. P. Lai, and M. J. Su 2009. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. British Journal of Pharmacology 157:381–91.
   PubMed Web of Science ®Google Scholar
• Chen, W.-P., T.-C. Chi, L.-M. Chuang, and M.-J. Su 2007. Resveratrol enhances insulin secretion by blocking K ATP and K V channels of beta cells. European Journal of Pharmacology 568:269–277.
   PubMed Web of Science ®Google Scholar
• Chen, W.-P., M.-J. Su, and L.-M. Hung 2007. In vitro electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant. European Journal of Pharmacology 554:196–204.
   PubMed Web of Science ®Google Scholar
• Chi, J. F., S. H. Chu, C. S. Lee, N. K. Chou, and M. J. Su 1996. Mechanical and electrophysiological effects of 8-oxoberberine (JKL1073A) on atrial tissue. British Journal of Pharmacology 118:503–512.
   PubMed Web of Science ®Google Scholar
• Chi, J.-F., S.-H. Chu, C.-S. Lee, and M.-J. Su 1997. Effects of 8-oxoberberine on sodium current in rat ventricular and human atrial myocytes. The Canadian Journal of Cardiology 13:1103–10.
   PubMed Web of Science ®Google Scholar
• Chong, E., S.-L. Chang, Y.-W. Hsiao, R. Singhal, S.-H. Liu, T. Leha, W.-Y. Lin, C.-P. Hsu, Y.-C. Chen, and Y.-J. Chen 2015. Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation. Heart Rhythm 12:1046–56.
   PubMed Web of Science ®Google Scholar
• Chow, S.-E., Y.-C. Hshu, J.-S. Wang, and J.-K. Chen 2007. Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. Journal of Applied Physiology 102:1520–27.
   PubMed Web of Science ®Google Scholar
• Derochette, S., T. Franck, A. Mouithys-Mickalad, J. Ceusters, G. Deby-Dupont, J.-P. Lejeune, P. Neven, and D. Serteyn 2013. Curcumin and resveratrol act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils. Chemico-Biological Interactions 206:186–93.
   PubMed Web of Science ®Google Scholar
• Dobrydneva, Y., R. L. Williams, G. Z. Morris, and P. F. Blackmore 2002. Dietary phytoestrogens and their synthetic structural analogues as calcium channel blockers in human platelets. Journal of Cardiovascular Pharmacology 40:399–410.
   PubMed Web of Science ®Google Scholar
• Drummond, G. R., and C. G. Sobey 2014. Endothelial NADPH oxidases: which NOX to target in vascular disease? Trends in Endocrinology & Metabolism 25:452–63.
   PubMed Web of Science ®Google Scholar
• Dudley, S. C., N. E. Hoch, L. A. McCann, C. Honeycutt, L. Diamandopoulos, T. Fukai, D. G. Harrison, S. I. Dikalov, and J. Langberg 2005. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage. Circulation 112:1266–73.
   PubMed Web of Science ®Google Scholar
• Engels, F., B. F. Renirie, B. A't Hart, R. P. Labadie, and F. P. Nijkamp 1992. Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism. FEBS Letters 305:254–56.
   PubMed Web of Science ®Google Scholar
• Fleenor, B. S., A. L. Sindler, N. K. Marvi, K. L. Howell, M. L. Zigler, M. Yoshizawa, and D. R. Seals 2013. Curcumin ameliorates arterial dysfunction and oxidative stress with aging. Experimental Gerontology 48:269–76.
   PubMed Web of Science ®Google Scholar
• Gonzalez, D. R., A. V. Treuer, G. Lamirault, V. Mayo, Y. Cao, R. A. Dulce, and J. M. Hare 2014. NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy. American Journal of Physiology-Heart and Circulatory Physiology 307:H710–21.
   PubMed Web of Science ®Google Scholar
• Hashemzaei, M., R. E. Heravi, R. Rezaee, A. Roohbakhsh, and G. Karimi 2017. Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders. European Journal of Pharmacology 802:44–51.
   PubMed Web of Science ®Google Scholar
• He, T., J. Xiong, L. Nie, Y. Yu, X. Guan, X. Xu, T. Xiao, K. Yang, L. Liu, and D. Zhang 2016. Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway. Journal of Molecular Medicine 94:1359–71.
   PubMed Web of Science ®Google Scholar
• Heijman, J., N. Voigt, S. Nattel, and D. Dobrev 2014. Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circulation Research 114:1483–99.
   PubMed Web of Science ®Google Scholar
• Heumüller, S., S. Wind, E. Barbosa-Sicard, H. H. Schmidt, R. Busse, K. Schröder, and R. P. Brandes 2008. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51:211–17.
   PubMed Web of Science ®Google Scholar
• Holland, J. A., and D. K. Johnson 1999. Prevention of atherosclerosis using NADPH oxidase inhibitors. US Patent 5,902,831.
   Google Scholar
• Hu, C.-W., Y. Sheng, Q. Zhang, H.-B. Liu, X. Xie, W.-C. Ma, R. Huo, and D.-L. Dong 2012. Curcumin inhibits hERG potassium channels in vitro. Toxicology Letters 208:192–96.
   PubMed Web of Science ®Google Scholar
• Imanshahidi, M., and H. Hosseinzadeh 2008. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytotherapy Research 22:999–1012.
   PubMed Web of Science ®Google Scholar
• Ingolfsson, H. I., R. E. Koeppe, and O. S. Andersen 2007. Curcumin is a modulator of bilayer material properties. Biochemistry 46:10384–91.
   PubMed Web of Science ®Google Scholar
• Johnson, D. K., K. J. Schillinger, D. M. Kwait, C. V. Hughes, E. J. McNamara, F. Ishmael, R. W. O'Donnell, M.-M. Chang, M. G. Hogg, and J. S. Dordick 2002. Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium 9:191–203.
   PubMed Web of Science ®Google Scholar
• Kang, B.-Y., J. A. Khan, S. Ryu, R. Shekhar, K.-B. Seung, and J. L. Mehta 2010. Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition. Journal of Cardiovascular Pharmacology 55:176–83.
   PubMed Web of Science ®Google Scholar
• Kapakos, G., V. Youreva, and A. K. Srivastava 2012. Cardiovascular protection by curcumin: molecular aspects. Indian Journal of Biochemistry & Biophysics 49:306–15.
   PubMed Web of Science ®Google Scholar
• Kim, Y. H., J. H. Lee, W. J. Shim, Y. M. Ro, G. H. Park, K. G. Becker, Y. S. Cho-Chung, and M.-k. Kim 2003. Gene expression profiling of oxidative stress on atrial fibrillation in humans. Experimental & Molecular Medicine 35:336.
   PubMed Web of Science ®Google Scholar
• Kim, Y. M., T. J. Guzik, Y. H. Zhang, M. H. Zhang, H. Kattach, C. Ratnatunga, R. Pillai, K. M. Channon, and B. Casadei 2005. A myocardial Nox2 containing NAD (P) H oxidase contributes to oxidative stress in human atrial fibrillation. Circulation Research 97:629–36.
   PubMed Web of Science ®Google Scholar
• Kim, Y. M., H. Kattach, C. Ratnatunga, R. Pillai, K. M. Channon, and B. Casadei 2008. Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery. Journal of the American College of Cardiology 51:68–74.
   PubMed Web of Science ®Google Scholar
• Kumar, A., K. Chopra, M. Mukherjee, R. Pottabathini, and D. K. Dhull 2015. Current knowledge and pharmacological profile of berberine: an update. European Journal of Pharmacology 761:288–97.
   PubMed Web of Science ®Google Scholar
• Lambeth, J. D. 2004. NOX enzymes and the biology of reactive oxygen. Nature Reviews Immunology 4:181–89.
   PubMed Web of Science ®Google Scholar
• Lau, C. W., X. Q. Yao, Z. Y. Chen, W. H. Ko, and Y. Huang 2001. Cardiovascular actions of berberine. Cardiovascular Drug Reviews 19:234–44.
   PubMed Web of Science ®Google Scholar
• Lee, S., H.-J. Lim, H.-Y. Park, K.-S. Lee, J.-H. Park, and Y. Jang 2006. Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo: berberine improves neointima formation in a rat model. Atherosclerosis 186:29–37.
   PubMed Web of Science ®Google Scholar
• Li, M., Q. Wang, Y. Chen, Z. Wang, Z. Liu, and S. Guo 2005. Resveratrol inhibits neuronal discharges in rat hippocampal CA1 area. Acta Physiologica Sinica 57:355.
   PubMedGoogle Scholar
• Li, N., L. Yang, D. Z. Dai, Q. J. Wang, and Y. Dai 2008. Chiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less α-adrenoceptor antagonism. Clinical and Experimental Pharmacology and Physiology 35:643–50.
   PubMed Web of Science ®Google Scholar
• Li, W., Y.-P. Wang, L. Gao, P.-P. Zhang, Q. Zhou, Q.-F. Xu, Z.-W. Zhou, K. Guo, R.-H. Chen, and H.-T. Yang 2013. Resveratrol protects rabbit ventricular myocytes against oxidative stress-induced arrhythmogenic activity and Ca2+ overload. Acta Pharmacologica Sinica 34:1164–73.
   PubMed Web of Science ®Google Scholar
• Liu, H., C. Wang, Z. Qiao, and Y. Xu 2017. Protective effect of curcumin against myocardium injury in ischemia reperfusion rats. Pharmaceutical Biology 55:1144–48.
   PubMed Web of Science ®Google Scholar
• Liu, T., Q. Shao, P. Korantzopoulos, E. Liu, G. Xu, and G. Li 2015. Serum levels of nicotinamide-adenine dinucleotide phosphate oxidase 4 are associated with non-valvular atrial fibrillation. Biomedical Reports 3:864–68.
   PubMed Web of Science ®Google Scholar
• Magyar, K., R. Halmosi, A. Palfi, G. Feher, L. Czopf, A. Fulop, I. Battyany, B. Sumegi, K. Toth, and E. Szabados 2012. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clinical Hemorheology and Microcirculation 50:179–87.
   PubMed Web of Science ®Google Scholar
• Maharani, N., Y. K. Ting, J. Cheng, A. Hasegawa, Y. Kurata, P. Li, Y. Nakayama, H. Ninomiya, N. Ikeda, and K. Morikawa 2015. Molecular mechanisms underlying urate-induced enhancement of Kv1. 5 channel expression in HL-1 atrial myocytes. Circulation Journal 79:2659–68.
   PubMed Web of Science ®Google Scholar
• Martyn, K. D., L. M. Frederick, K. von Loehneysen, M. C. Dinauer, and U. G. Knaus 2006. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cellular Signalling 18:69–82.
   PubMed Web of Science ®Google Scholar
• Meng, Z., C. Yan, Q. Deng, D.-F. Gao, and X.-l. Niu 2013. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacologica Sinica 34:901–11.
   PubMed Web of Science ®Google Scholar
• Meyer, J. W., and M. E. Schmitt 2000. A central role for the endothelial NADPH oxidase in atherosclerosis. FEBS Letters 472:1–4.
   PubMed Web of Science ®Google Scholar
• Nattel, S., B. Burstein, and D. Dobrev 2008. Atrial remodeling and atrial fibrillation. Circulation: Arrhythmia and Electrophysiology 1:62–73.
   PubMed Web of Science ®Google Scholar
• Nattel, S., and D. Dobrev 2016. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nature Reviews Cardiology 13:575–90.
   PubMed Web of Science ®Google Scholar
• Nattel, S., and M. Harada 2014. Atrial remodeling and atrial fibrillation: recent advances and translational perspectives. Journal of the American College of Cardiology 63:2335–45.
   PubMed Web of Science ®Google Scholar
• Perassa, L. A., M. E. Graton, S. R. Potje, J. A. Troiano, M. S. Lima, G. T. Vale, A. A. Pereira, A. C. M. Nakamune, D. H. Sumida, and C. R. Tirapelli 2016. Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR. Vascular Pharmacology 87:38–48.
   PubMed Web of Science ®Google Scholar
• Piccini, J. P., B. G. Hammill, M. F. Sinner, P. N. Jensen, A. F. Hernandez, S. R. Heckbert, E. J. Benjamin, and L. H. Curtis 2012. Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993–2007. Circulation: Cardiovascular Quality and Outcomes 5:85–93.
   PubMed Web of Science ®Google Scholar
• Privratsky, J. R., L. E. Wold, J. R. Sowers, M. T. Quinn, and J. Ren 2003. AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes. Hypertension 42:206–12.
   PubMed Web of Science ®Google Scholar
• Qin, F., M. Simeone, and R. Patel 2007. Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radical Biology and Medicine 43:271–81.
   PubMed Web of Science ®Google Scholar
• Qiu, J., J. Zhao, J. Li, X. Liang, Y. Yang, Z. Zhang, X. Zhang, H. Fu, P. Korantzopoulos, and T. Liu 2016. NADPH oxidase inhibitor apocynin prevents atrial remodeling in alloxan-induced diabetic rabbits. International Journal of Cardiology 221:812–19.
   PubMed Web of Science ®Google Scholar
• Razavi-Azarkhiavi, K., M. Iranshahy, A. Sahebkar, K. Shirani, and G. Karimi 2016. The protective role of phenolic compounds against doxorubicin-induced cardiotoxicity: A comprehensive review. Nutrition and Cancer 68:892–917.
   PubMed Web of Science ®Google Scholar
• Reilly, S. N., R. Jayaram, K. Nahar, C. Antoniades, S. Verheule, K. M. Channon, N. J. Alp, U. Schotten, and B. Casadei 2011. Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation clinical perspective. Circulation 124:1107–17.
   PubMed Web of Science ®Google Scholar
• Rodiño-Janeiro, B. K., B. Paradela-Dobarro, M. I. Castiñeiras-Landeira, S. Raposeiras-Roubín, J. R. González-Juanatey, and E. Álvarez 2013. Current status of NADPH oxidase research in cardiovascular pharmacology. Vascular Health and Risk Management 9:401–28.
   PubMedGoogle Scholar
• Rodriguez-Menchaca, A., T. Ferrer-Villada, J. Lara, D. Fernandez, R. A. Navarro-Polanco, and J. A. Sanchez-Chapula 2006. Block of HERG channels by berberine: mechanisms of voltage-and state-dependence probed with site-directed mutant channels. Journal of Cardiovascular Pharmacology 47:21–29.
   PubMed Web of Science ®Google Scholar
• Sánchez-Chapula, J. 1996. Increase in action potential duration and inhibition of the delayed rectifier outward current IK by berberine in cat ventricular myocytes. British Journal of Pharmacology 117:1427–34.
   PubMed Web of Science ®Google Scholar
• Sarkar, A., R. De, and A. K. Mukhopadhyay 2016. Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases. World Journal of Gastroenterology 22:2736.
   PubMed Web of Science ®Google Scholar
• Sarna, L. K., N. Wu, S.-Y. Hwang, Y. L. Siow, and O. Karmin. 2010. Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages. Canadian Journal of Physiology and Pharmacology 88:369–78.
   PubMed Web of Science ®Google Scholar
• Sharma, N., and B. Nehru 2016. Apocyanin, a microglial NADPH oxidase inhibitor prevents dopaminergic neuronal degeneration in lipopolysaccharide-induced parkinson's disease model. Molecular Neurobiology 53:3326–37.
   PubMed Web of Science ®Google Scholar
• Shimoni, Y., D. Hunt, M. Chuang, K. Chen, G. Kargacin, and D. Severson 2005. Modulation of potassium currents by angiotensin and oxidative stress in cardiac cells from the diabetic rat. The Journal of Physiology 567:177–90.
   PubMed Web of Science ®Google Scholar
• Sirker, A., M. Zhang, and A. M. Shah 2011. NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. Basic Research in Cardiology 106:735–47.
   PubMed Web of Science ®Google Scholar
• Soetikno, V., K. Watanabe, F. R. Sari, M. Harima, R. A. Thandavarayan, P. T. Veeraveedu, W. Arozal, V. Sukumaran, A. P. Lakshmanan, and S. Arumugam 2011. Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats. Molecular Nutrition & Food Research 55:1655–65.
   PubMed Web of Science ®Google Scholar
• Son, Y. K., I.-W. Choi, and W. S. Park 2013. The inhibitory effect of curcumin on voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Biochemical and Biophysical Research Communications 430:307–12.
   PubMed Web of Science ®Google Scholar
• Sovari, A., and S. Dudley 2010. Atrial fibrillation and oxidative stress. Studies on Cardiovascular Disorders 1:373–89.
   Google Scholar
• Sovari, A. A. 2016. Cellular and molecular mechanisms of arrhythmia by oxidative stress. Cardiology Research and Practice 2016:9656078.
   PubMed Web of Science ®Google Scholar
• Spanier, G., H. Xu, N. Xia, S. Tobias, S. Deng, L. Wojnowski, U. Forstermann, and H. Li 2009. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol 60:111–16.
   PubMed Web of Science ®Google Scholar
• Tang, Y., J. Xu, W. Qu, X. Peng, P. Xin, X. Yang, C. Ying, X. Sun, and L. Hao 2012. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. The Journal of Nutritional Biochemistry 23:1410–16.
   PubMed Web of Science ®Google Scholar
• Tang, Y. L., and S. W. Chan 2014. A review of the pharmacological effects of piceatannol on cardiovascular diseases. Phytotherapy Research 28:1581–88.
   PubMed Web of Science ®Google Scholar
• Thirunavukkarasu, M., S. V. Penumathsa, S. Koneru, B. Juhasz, L. Zhan, H. Otani, D. Bagchi, D. K. Das, and N. Maulik 2007. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radical Biology and Medicine 43:720–29.
   PubMed Web of Science ®Google Scholar
• Tomé-Carneiro, J., M. Gonzálvez, M. Larrosa, M. J. Yáñez-Gascón, F. J. García-Almagro, J. A. Ruiz-Ros, F. A. Tomás-Barberán, M. T. García-Conesa, and J. C. Espín 2013. Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective. Annals of the New York Academy of Sciences 1290:37–51.
   PubMed Web of Science ®Google Scholar
• Trujillo, J., E. Molina-Jijón, O. N. Medina-Campos, R. Rodríguez-Muñoz, J. L. Reyes, M. L. Loredo, D. Barrera-Oviedo, E. Pinzón, D. S. Rodríguez-Rangel, and J. Pedraza-Chaverri 2016. Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress. Food & Function 7:279–93.
   PubMed Web of Science ®Google Scholar
• Tsai, C.-T., C.-D. Tseng, J.-J. Hwang, C.-K. Wu, C.-C. Yu, Y.-C. Wang, W.-P. Chen, L.-P. Lai, F.-T. Chiang, and J.-L. Lin 2010. Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor β1. Cardiovascular Research 89:805–15.
   PubMed Web of Science ®Google Scholar
• Ungvari, Z., N. Labinskyy, P. Mukhopadhyay, J. T. Pinto, Z. Bagi, P. Ballabh, C. Zhang, P. Pacher, and A. Csiszar 2009. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. American Journal of Physiology-Heart and Circulatory Physiology 297:H1876–81.
   PubMed Web of Science ®Google Scholar
• Vilar-Pereira, G., V. C. Carneiro, H. Mata-Santos, A. R. Vicentino, I. P. Ramos, N. L. Giarola, D. F. Feijó, J. R. Meyer-Fernandes, H. A. Paula-Neto, and E. Medei 2016. Resveratrol reverses functional chagas heart disease in mice. PLoS Pathog 12:e1005947.
   PubMed Web of Science ®Google Scholar
• Violi, F., D. Pastori, P. Pignatelli, and L. Loffredo 2014. Antioxidants for prevention of atrial fibrillation: a potentially useful future therapeutic approach? A review of the literature and meta-analysis. Europace 16:1107–16.
   PubMed Web of Science ®Google Scholar
• Virdis, A., M. Gesi, and S. Taddei 2016. Impact of apocynin on vascular disease in hypertension. Vascular Pharmacology 87:1–5.
   PubMed Web of Science ®Google Scholar
• Vlachos, K., K. P. Letsas, P. Korantzopoulos, T. Liu, S. Georgopoulos, A. Bakalakos, N. Karamichalakis, S. Xydonas, M. Efremidis, and A. Sideris 2016. Prediction of atrial fibrillation development and progression: Current perspectives. World Journal of Cardiology 8:267.
   PubMed Web of Science ®Google Scholar
• Wang, C., J. Li, X. Lv, M. Zhang, Y. Song, L. Chen, and Y. Liu 2009. Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin. European Journal of Pharmacology 620:131–37.
   PubMed Web of Science ®Google Scholar
• Wang, F., G. Zhao, L. Cheng, H.-Y. Zhou, L.-Y. Fu, and W.-X. Yao 2004. Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Research 999:91–97.
   PubMed Web of Science ®Google Scholar
• Wang, L.-H., X.-L. Li, Q. Li, Y. Fu, H.-J. Yu, Y.-Q. Sun, L. Zhang, and H.-L. Shan 2012. Berberine alleviates ischemic arrhythmias via recovering depressed I to and I Ca currents in diabetic rats. Phytomedicine 19:206–10.
   PubMed Web of Science ®Google Scholar
• Wang, Y.-X., Y.-M. Zheng, and X.-B. Zhou 1996. Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes. European Journal of Pharmacology 316:307–15.
   PubMed Web of Science ®Google Scholar
• Whitehouse, S., P.-L. Chen, A. L. Greenshields, M. Nightingale, D. W. Hoskin, and K. Bedard 2016. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. Phytomedicine 23:1494–503.
   PubMed Web of Science ®Google Scholar
• Won, S. J., X. N. Tang, S. W. Suh, M. A. Yenari, and R. A. Swanson 2011. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production. Annals of Neurology 70:583–90.
   PubMed Web of Science ®Google Scholar
• Wongeakin, N., P. Bhattarakosol, and S. Patumraj 2014. Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: Txnip, ICAM-1, and NOX2 expressions. BioMed Research International 2014:161346.
   PubMed Web of Science ®Google Scholar
• Wu, D.-C., D. B. Ré, M. Nagai, H. Ischiropoulos, and S. Przedborski 2006. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proceedings of the National Academy of Sciences 103:12132–37.
   PubMed Web of Science ®Google Scholar
• Ximenes, V. F., M. P. Kanegae, S. R. Rissato, and M. S. Galhiane 2007. The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition. Archives of Biochemistry and Biophysics 457:134–41.
   PubMed Web of Science ®Google Scholar
• Xiong, W., J. Mactaggart, R. Knispel, J. Worth, Z. Zhu, Y. Li, Y. Sun, B. T. Baxter, and J. Johanning 2009. Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model. Atherosclerosis 202:128–34.
   PubMed Web of Science ®Google Scholar
• Yagi, S., M. Akaike, K.-I. Aihara, K. Ishikawa, T. Iwase, Y. Ikeda, T. Soeki, S. Yoshida, Y. Sumitomo-Ueda, and T. Matsumoto 2010. Endothelial nitric oxide synthase–independent protective action of statin against angiotensin II–induced atrial remodeling via reduced oxidant injury. Hypertension 55:918–23.
   PubMed Web of Science ®Google Scholar
• Yao, J., W. Kong, and J. Jiang 2015. Learning from berberine: Treating chronic diseases through multiple targets. Science China Life Sciences 58:854–59.
   PubMed Web of Science ®Google Scholar
• Youn, J.-Y., J. Zhang, Y. Zhang, H. Chen, D. Liu, P. Ping, J. N. Weiss, and H. Cai 2013. Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase. Journal of Molecular and Cellular Cardiology 62:72–79.
   PubMed Web of Science ®Google Scholar
• Yu, W., W. Zha, Z. Ke, Q. Min, C. Li, H. Sun, and C. Liu 2016. Curcumin protects neonatal rat cardiomyocytes against high glucose-induced apoptosis via PI3K/Akt signalling pathway. Journal of Diabetes Research 2016:4158591.
   PubMed Web of Science ®Google Scholar
• Zarzuelo, M. J., R. López-Sepúlveda, M. Sánchez, M. Romero, M. Gómez-Guzmán, Z. Ungvary, F. Pérez-Vizcaíno, R. Jiménez, and J. Duarte 2013. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Biochemical Pharmacology 85:1288–96.
   PubMed Web of Science ®Google Scholar
• Zern, T. L., K. L. West, and M. L. Fernandez 2003. Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. The Journal of Nutrition 133:2268–72.
   PubMed Web of Science ®Google Scholar
• Zhang, D.-X., K. Ren, Y. Guan, Y.-T. Wang, and Z.-L. Shan 2014. Protective effects of apocynin on atrial electrical remodeling and oxidative stress in a rabbit rapid atrial pacing model. Chinese Journal of Physiology 57:76–82.
   PubMed Web of Science ®Google Scholar
• Zhang, J., J. Y. Youn, A. Kim, R. Ramire, L. Gao, D. Ngo, J. Scovotti, A. Mahajan, and H. L. Cai 2012. NOX4-dependent hydrogen peroxide overproduction in human atrial fibrillation and HL-1 atrial cells: relationship to hypertension. Frontiers in Physiology 3:140.
   PubMed Web of Science ®Google Scholar
• Zhang, L.-P., H.-J. Ma, J. Zhao, and Q.-S. Wang 2005. Effects of resveratrol on delayed afterdepolarization and triggered activity induced by ouabain in guinea pig papillary muscles. Acta Physiologica Sinica 57:361–66.
   PubMedGoogle Scholar
• Zhang, M., A. C. Brewer, K. Schröder, C. X. Santos, D. J. Grieve, M. Wang, N. Anilkumar, B. Yu, X. Dong, and S. J. Walker 2010. NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proceedings of the National Academy of Sciences 107:18121–26.
   PubMed Web of Science ®Google Scholar
• Zhang, M., C.-M. Wang, J. Li, Z.-J. Meng, S.-N. Wei, J. Li, R. Bucala, Y.-L. Li, and L. Chen 2013. Berberine protects against palmitate-induced endothelial dysfunction: involvements of upregulation of AMPK and eNOS and downregulation of NOX4. Mediators of Inflammation 2013:260464.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Y. Liu, T. Wang, B. Li, H. Li, Z. Wang, and B. Yang 2006. Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms. Biochemical and Biophysical Research Communications 340:1192–99.
   PubMed Web of Science ®Google Scholar
• Zhao, W.-C., B. Zhang, M.-J. Liao, W.-X. Zhang, W.-Y. He, H.-B. Wang, and C.-X. Yang 2014. Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord. Neuroscience Letters 560:81–85.
   PubMed Web of Science ®Google Scholar
• Zhou, Z.-W., H.-C. Zheng, L.-F. Zhao, W. Li, J.-W. Hou, Y. Yu, P.-Z. Miao, and J.-M. Zhu 2015. Effect of berberine on acetylcholine-induced atrial fibrillation in rabbit. American Journal of Translational Research 7:1450.
   PubMed Web of Science ®Google Scholar
• Ziolo, M. T., and P. J. Mohler 2015. Defining the role of oxidative stress in atrial fibrillation and diabetes. Journal of Cardiovascular Electrophysiology 26:223.
   PubMed Web of Science ®Google Scholar