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Phenolic compounds as natural and multifunctional anti-obesity agents: A review

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References

  • Adnyana, I., E. Sukandar, A. Yuniarto, and S. Finna. 2014. Anti-obesity effect of the pomegranate leaves ethanol extract (Punicagranatuml.) in high-fat diet induced mice. International Journal of Pharmacy and Pharmaceutical Sciences. 6:626–31.
  • Agouni, A., A. Lagrue-Lak-Hal, H. A. Mostefai, A. Tesse, P. Mulder, P. Rouet, F. Desmoulin, C. Heymes, M. C. Martínez, and R. Andriantsitohaina. 2009. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PloS one. 4:e5557.
  • Akter, R., A. Nessa, M. F. Husain, F. Wahed, N. Khatun, M. Yesmin, S. Nasreen, and T. Tajkia. 2017. Effect of Obesity on Fasting Blood Sugar. Mymensingh Med J. 26:7–11.
  • Alarcon-Aguilar, F. J., A. Zamilpa, M. D. Perez-Garcia, J. C. Almanza-Perez, E. Romero-Nunez, E. A. Campos-Sepulveda, L. I. Vazquez-Carrillo, and R. Roman-Ramos. 2007. Effect of Hibiscus sabdariffa on obesity in MSG mice. J Ethnopharmacol. 114:66–71.
  • Andres-Lacueva, C., M. Monagas, N. Khan, M. Izquierdo-Pulido, M. Urpi-Sarda, J. Permanyer, and R. Lamuela-Raventos. 2008. Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process. J Agric Food Chem. 56:3111–17.
  • Bargalló, M. V., A. A. Grau, J. de Dios Fernández-Larrea, G. P. Anguiano, M. C. B. Segarra, M. J. S. Rovira, L. A. Ferré, and M. B. Olivé. 2006. Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet. J Nutr Biochem. 17:139–42.
  • Basterra-Gortari, F. J., J. J. Beunza, M. Bes–Rastrollo, E. Toledo, M. García–López, and M. A. Martínez–González. 2011. Tendencia creciente de la prevalencia de obesidad mórbida en España: de 1, 8 a 6, 1 por mil en 14 años. Revista Española de Cardiología. 64:424–26.
  • Basu, A., M. Du, M. J. Leyva, K. Sanchez, N. M. Betts, M. Wu, C. E. Aston, and T. J. Lyons. 2010. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr. 140:1582–87.
  • Belguith-Hadriche, O., S. Ammar, M. del Mar Contreras, H. Fetoui, A. Segura-Carretero, A. El Feki, and M. Bouaziz. 2017. HPLC-DAD-QTOF-MS profiling of phenolics from leaf extracts of two Tunisian fig cultivars: Potential as a functional food. Biomedicine & Pharmacotherapy. 89:185–93.
  • Belguith-Hadriche, O., S. Ammar, M. del Mar Contreras, M. Turki, A. Segura-Carretero, A. El Feki, F. Makni-Ayedi, and M. Bouaziz. 2016. Antihyperlipidemic and Antioxidant Activities of Edible Tunisian Ficus carica. Plant Foods for Human Nutrition. 71:183–189.
  • Belza, A., E. Frandsen, and J. Kondrup. 2007. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes. 31:121–30.
  • Berg, A. H., and P. E. Scherer. 2005. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 96:939–49.
  • Blancas-Flores, G., J. C. Almanza-Pérez, R. I. López-Roa, F. J. Alarcón-Aguilar, R. García-Macedo, and M. Cruz. 2010. Obesity as an inflammatory process. Bol Med Hosp Infant Mex. 67:88–96.
  • Bogdanski, P., J. Suliburska, M. Szulinska, M. Stepien, D. Pupek-Musialik, and A. Jablecka. 2012. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 32:421–27.
  • Bognar, E., Z. Sarszegi, A. Szabo, B. Debreceni, N. Kalman, Z. Tucsek, B. Sumegi, and F. Gallyas, Jr.. 2013. Antioxidant and anti-inflammatory effects in RAW264. 7 macrophages of malvidin, a major red wine polyphenol. PLoS One. 8:e65355.
  • Borrás-Linares, I., Z. Stojanović, R. Quirantes-Piné, D. Arráez-Román, J. Švarc-Gajić, A. Fernández-Gutiérrez, and A. Segura-Carretero. 2014. Rosmarinus officinalis leaves as a natural source of bioactive compounds. International journal of molecular sciences. 15:20585–606.
  • Bruun, J. M., J. W. Helge, B. Richelsen, and B. Stallknecht. 2006. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab. 290:E961–7.
  • Bustanji, Y., A. Issa, M. Mohammad, M. Hudaib, K. Tawah, H. Alkhatib, I. Almasri, and B. Al-Khalidi. 2010. Inhibition of hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituents. Journal of Medicinal Plants Research. 4:2235–42.
  • Cádiz-Gurrea, M., J. Lozano-Sanchez, M. Contreras-Gámez, L. Legeai-Mallet, S. Fernández-Arroyo, and A. Segura-Carretero. 2014. Isolation, comprehensive characterization and antioxidant activities of Theobroma cacao extract. Journal of Functional Foods. 10:485–98.
  • Cantley, J. 2014. The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis. Mamm Genome. 25:442–54.
  • Chang, H-., C-. Peng, D-. Yeh, E-. Kao, and C-. Wang. 2014. Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans. Food Funct. 5:734–39.
  • Chantre, P., and D. Lairon. 2002. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine. 9:3–8.
  • Chen, I-., C-. Liu, J-. Chiu, and C-. Hsu. 2016. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 35:592–99.
  • Contreras Gámez, M. M., C. Rodríguez Pérez, P. García Salas, and A. Segura Carretero. 2014. Polyphenols from the mediterranean diet: Structure, analysis and health evidence. In:Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits, 2:141–209.
  • Cypess, A. M., and C. R. Kahn. 2010. Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 17:143–149.
  • Dallas, C., A. Gerbi, Y. Elbez, P. Caillard, N. Zamaria, and M. Cloarec. 2014. Clinical Study to Assess the Efficacy and Safety of a Citrus Polyphenolic Extract of Red Orange, Grapefruit, and Orange (Sinetrol-XPur) on Weight Management and Metabolic Parameters in Healthy Overweight Individuals. Phytotherapy Research. 28:212–218.
  • de Nigris, F., M. L. Balestrieri, S. Williams-Ignarro, F. P. D'Armiento, C. Fiorito, L. J. Ignarro, and C. Napoli. 2007. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide. 17:50–54.
  • Décordé, K., P. Teissèdre, T. Sutra, E. Ventura, J. Cristol, and J. Rouanet. 2009. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Molecular nutrition & food research. 53:659–66.
  • Dulloo, A., J. Seydoux, L. Girardier, P. Chantre, and J. Vandermander. 2000. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes. 24:252.
  • Dulloo, A. G., C. Duret, D. Rohrer, L. Girardier, N. Mensi, M. Fathi, P. Chantre, and J. Vandermander. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 70:1040–45.
  • Ebaid, G. M., F. R. Seiva, K. K. Rocha, G. A. Souza, and E. L. Novelli. 2010. Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes. Nutrition journal. 9:46.
  • Finkelstein, E. A., O. A. Khavjou, H. Thompson, J. G. Trogdon, L. Pan, B. Sherry, and W. Dietz. 2012. Obesity and Severe Obesity Forecasts Through 2030. Am J Prev Med. 42:563–70.
  • Fresco, P., F. Borges, C. Diniz, and M. P. M. Marques. 2006. New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 26:747–66.
  • Golomb, B. A., S. Koperski, and H. L. White. 2012. Association between more frequent chocolate consumption and lower body mass index. Arch Intern Med. 172:519–21.
  • Gómez-Navarro, C. G. 2009. Efecto antioxidante y antihipertensivo de diferentes compuestos fenólicos del aceite de oliva virgen“ in vitro”. Universitat Rovira i Virgili.
  • Gondoin, A., D. Grussu, D. Stewart, and G. J. McDougall. 2010. White and green tea polyphenols inhibit pancreatic lipase in vitro. Food Res Int. 43:1537–44.
  • Gosmann, G., A. G. Barlette, T. Dhamer, D. P. Arçari, J. C. Santos, E. R. de Camargo, S. Acedo, A. Gambero, S. C. B. Gnoatto, and M. L. Ribeiro. 2012. Phenolic compounds from mate (Ilex paraguariensis) inhibit adipogenesis in 3T3-L1 preadipocytes. Plant foods for human nutrition. 67:156–61.
  • Gourineni, V., N. F. Shay, S. Chung, A. K. Sandhu, and L. Gu. 2012. Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice. J Agric Food Chem. 60:7674–81.
  • Graf, B. L., I. Raskin, W. T. Cefalu, and D. M. Ribnicky. 2010. Plant-derived therapeutics for the treatment of metabolic syndrome. Curr Opin Invest Drugs. 11:1107–15.
  • Grosso, G., U. Stepaniak, R. Topor-Mądry, K. Szafraniec, and A. Pająk. 2014. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Nutrition. 30:1398–03.
  • Guenard, F., Y. Deshaies, K. Cianflone, J. G. Kral, P. Marceau, and M. C. Vohl. 2013. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc Natl Acad Sci U S A. 110:11439–11444.
  • Gurib-Fakim, A. 2006. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 27:1–93.
  • Gurrola-Díaz, C. M., P. M. García-López, S. Sánchez-Enríquez, R. Troyo-Sanromán, I. Andrade-González, and J. F. Gómez-Leyva. 2010. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomedicine. 17:500–05.
  • Hakim, I. A., V. Hartz, R. B. Harris, D. Balentine, U. M. Weisgerber, E. Graver, R. Whitacre, and D. Alberts. 2001. Reproducibility and relative validity of a questionnaire to assess intake of black tea polyphenols in epidemiological studies. Cancer Epidemiol Biomarkers Prev. 10:667–678.
  • Halvorsen, B. L., M. H. Carlsen, K. M. Phillips, S. K. Bohn, K. Holte, D. Jacobs, Jr., and R. Blomhoff. 2006. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 84:95–135.
  • Han, C. Y. 2016. Roles of reactive oxygen species on insulin resistance in adipose tissue. Diabetes & Metabolism Journal. 40:272–79.
  • Han, H. J., U. J. Jung, H. Kim, S. Cho, A. H. Kim, Y. Han, and M. Choi. 2016. Combined Supplementation with Grape Pomace and Omija Fruit Ethanol Extracts Dose-Dependently Improves Body Composition, Plasma Lipid Profiles, Inflammatory Status, and Antioxidant Capacity in Overweight and Obese Subjects. Journal of medicinal food. 19:170–80.
  • Heilbronn, L. K., M. Noakes, and P. M. Clifton. 2001. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Arterioscler Thromb Vasc Biol. 21:968–70.
  • Henning, S. M., C. Fajardo-Lira, H. W. Lee, A. A. Youssefian, V. L. Go, and D. Heber. 2003. Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity. Nutr Cancer. 45:226–35.
  • Hernández-Ledesma, B., M. del Mar Contreras, and I. Recio. 2011. Antihypertensive peptides: production, bioavailability and incorporation into foods. Adv Colloid Interface Sci. 165:23–35.
  • Herranz-López, M., E. Barrajón-Catalán, A. Segura-Carretero, J. A. Menéndez, J. Joven, and V. Micol. 2015. Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms. Phytomedicine. 22:605–14.
  • Herranz-López, M., S. Fernández-Arroyo, A. Pérez-Sanchez, E. Barrajón-Catalán, R. Beltrán-Debón, J. A. Menéndez, C. Alonso-Villaverde, A. Segura-Carretero, J. Joven, and V. Micol. 2012. Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications. Phytomedicine. 19:253–61.
  • Hill, A. M., A. M. Coates, J. D. Buckley, R. Ross, F. Thielecke, and P. R. C. Howe. 2007. Can egcg reduce abdominal fat in obese subjects? J Am Coll Nutr. 26:396S–402S.
  • Howe, L. R., K. Subbaramaiah, C. A. Hudis, and A. J. Dannenberg. 2013. Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin Cancer Res. 19:6074–83.
  • Hruby, A., and F. B. Hu. 2015. The Epidemiology of Obesity: A Big Picture. Pharmacoeconomics. 33:673–89.
  • Hsu, C., and G. Yen. 2008. Phenolic compounds: evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms. Molecular nutrition & food research. 52:53–61.
  • Hsu, C., T. Tsai, Y. Kao, K. Hwang, T. Tseng, and P. Chou. 2008. Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition. 27:363–70.
  • Huang, J., Y. Wang, Z. Xie, Y. Zhou, Y. Zhang, and X. Wan. 2014. The anti-obesity effects of green tea in human intervention and basic molecular studies. Eur J Clin Nutr. 68:1075–87.
  • Hursel, R., W. Viechtbauer, and M. Westerterp-Plantenga. 2009. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes. 33:956–61.
  • Izaola, O., D. de Luis, I. Sajoux, J. C. Domingo, and M. Vidal. 2015. Inflamación y obesidad (lipoinflamación). Nutricion hospitalaria. 31:2352–2358.
  • Jayaprakasam, B., L. K. Olson, R. E. Schutzki, M. Tai, and M. G. Nair. 2006. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem. 54:243–48.
  • Jiang, H. Z., X. F. Quan, W. X. Tian, J. M. Hu, P. C. Wang, S. Z. Huang, Z. Q. Cheng, W. J. Liang, J. Zhou, and X. F. Ma. 2010. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. Bioorg Med Chem Lett. 20:6045–47.
  • Joven, J., I. March, E. Espinel, S. Fernández-Arroyo, E. Rodríguez-Gallego, G. Aragonès, R. Beltrán-Debón, C. Alonso-Villaverde, L. Rios, V. Martin-Paredero, J. A. Menendez, V. Micol, A. Segura-Carretero, and J. Camps. 2014. Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function. Mol Nutr Food Res. 58:1374–78.
  • Kar, P., D. Laight, H. Rooprai, K. Shaw, and M. Cummings. 2009. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabetic Med. 26:526–31.
  • Kawabata, F., N. Inoue, S. Yazawa, T. Kawada, K. Inoue, and T. Fushiki. 2006. Effects of CH-19 sweet, a non-pungent cultivar of red pepper, in decreasing the body weight and suppressing body fat accumulation by sympathetic nerve activation in humans. Biosci Biotechnol Biochem. 70:2824–35.
  • Khan, A., M. Safdar, M. M. Ali Khan, K. N. Khattak, and R. A. Anderson. 2003. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 26:3215–18.
  • Kris-Etherton, P. M., K. D. Hecker, A. Bonanome, S. M. Coval, A. E. Binkoski, K. F. Hilpert, A. E. Griel, and T. D. Etherton. 2002. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med. 113:71–88.
  • Kuriyan, R., D. R. Kumar, R. Rajendran, and A. V. Kurpad. 2010. An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial. BMC complementary and alternative medicine. 10:27.
  • Labban, L., U. E. Mustafa, and Y. M. Ibrahim. 2014. The effects of rosemary (Rosmarinus officinalis) leaves powder on glucose level, lipid profile and lipid perodoxation. International Journal of Clinical Medicine. 2014, 5:297–304.
  • Larson, N., D. S. Ward, S. B. Neelon, and M. Story. 2011. What Role Can Child-Care Settings Play in Obesity Prevention? A Review of the Evidence and Call for Research Efforts. J Am Diet Assoc. 111:1343–62.
  • Lehtonen, H., J. Suomela, R. Tahvonen, B. Yang, M. Venojärvi, J. Viikari, and H. Kallio. 2011. Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. Eur J Clin Nutr. 65:394–01.
  • Lei, F., X. Zhang, W. Wang, D. Xing, W. Xie, H. Su, and L. Du. 2007. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes. 31:1023–29.
  • Lin, T., H. Lin, C. Chen, M. Lin, M. Chou, and C. Wang. 2007. Hibiscus sabdariffa extract reduces serum cholesterol in men and women. Nutr Res. 27:140–45.
  • Loizzo, M., G. LECCE, E. Boselli, F. Menichini, and N. Frega. 2011. Inhibitory activity of phenolic compounds from extra virgin olive oils on the enzymes involved in diabetes, obesity and hypertension. J Food Biochem. 35:381–99.
  • Mang, B., M. Wolters, B. Schmitt, K. Kelb, R. Lichtinghagen, D. Stichtenoth, and A. Hahn. 2006. Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 36:340–44.
  • Massolt, E. T., P. M. van Haard, J. F. Rehfeld, E. F. Posthuma, E. van der Veer, and D. H. Schweitzer. 2010. Appetite suppression through smelling of dark chocolate correlates with changes in ghrelin in young women. Regul Pept. 161:81–86.
  • Mielgo-Ayuso, J., L. Barrenechea, P. Alcorta, E. Larrarte, J. Margareto, and I. Labayen. 2014. Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial. Br J Nutr. 111:1263–71.
  • Min, S., H. Yang, S. Seo, S. Shin, M. Chung, J. Kim, S. Lee, H. Lee, and K. Lee. 2013. Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor. Int J Obes. 37:584–92.
  • Mirza, N. M., and J. A. Yanovski. 2014. Prevalence and consequences of pediatric obesity. Handbook of obesity: epidemology, etiology, and physiopathology.Florida: Taylor & Francis Ltd. 1:55–74.
  • Monteiro, R., and I. Azevedo. 2010. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010:1–10 10.1155/2010/289645. Epub 2010 Jul 14.
  • Nicklas, B. J., W. Ambrosius, S. P. Messier, G. D. Miller, B. W. Penninx, R. F. Loeser, S. Palla, E. Bleecker, and M. Pahor. 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr. 79:544–51.
  • Nielsen, F. H. 2014. Should bioactive trace elements not recognized as essential, but with beneficial health effects, have intake recommendations. Journal of Trace Elements in Medicine and Biology. 28:406–08.
  • Nogueira, L. de. P., M. P. Knibel, M. R. S. G. Torres, J. F. Nogueira Neto, and A. F. Sanjuliani. 2012. Consumption of high-polyphenol dark chocolate improves endothelial function in individuals with stage 1 hypertension and excess body weight. Intern J Hypertens, 2012, 147321. http://doi.org/10.1155/2012/147321
  • Nomura, S., T. Ichinose, M. Jinde, Y. Kawashima, K. Tachiyashiki, and K. Imaizumi. 2008. Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue. J Nutr Biochem. 19:840–47.
  • Oana, F., H. Takeda, K. Hayakawa, A. Matsuzawa, S. Akahane, M. Isaji, and M. Akahane. 2005. Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin. Metab Clin Exp. 54:995–01.
  • Oboh, G., A. A. Olabiyi, A. J. Akinyemi, and A. O. Ademiluyi. 2014. Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya). J Basic Clin Physiol Pharmacol. 25:21–34.
  • Oi-Kano, Y., T. Kawada, T. Watanabe, F. Koyama, K. Watanabe, R. Senbongi, and K. Iwai. 2008. Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol. 54:363–70.
  • Ojeda, D., E. Jiménez-Ferrer, A. Zamilpa, A. Herrera-Arellano, J. Tortoriello, and L. Alvarez. 2010. Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa. J Ethnopharmacol. 127:7–10.
  • Olaokun, O. O., L. J. McGaw, J. N. Eloff, and V. Naidoo. 2013. Evaluation of the inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of extracts of ten African Ficus species (Moraceae) used traditionally to treat diabetes. BMC Complementary and Alternative medicine. 13:94.
  • Ono, K., M. Tsukamoto-Yasui, Y. Hara-Kimura, N. Inoue, Y. Nogusa, Y. Okabe, K. Nagashima, and F. Kato. 2011. Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. J Appl Physiol (1985). 110:789–98.
  • Park, E., I. Edirisinghe, Y. Y. Choy, A. Waterhouse, and B. Burton-Freeman. 2015. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: A randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 115:226–38.
  • Perez-Jimenez, J., L. Fezeu, M. Touvier, N. Arnault, C. Manach, S. Hercberg, P. Galan, and A. Scalbert. 2011. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr. 93:1220–28.
  • Perusse, L., T. Rice, and C. Bouchard. 2014. Genetic component to obesity: evidence from genetic epidemiology. Handbook of obesity.Boca Raton: Taylor and Francis Group. 1:91–104.
  • Prior, R. L., X. Wu, L. Gu, T. Hager, A. Hager, S. Wilkes, and L. Howard. 2009. Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet. Mol Nutr Food Res. 53:1406–18.
  • Rabadan-Chávez, G., L. Quevedo-Corona, A. M. Garcia, E. Reyes-Maldonado, and M. E. Jaramillo-Flores. 2016. Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue. Journal of Functional Foods. 20:54–67.
  • Rabadán-Chávez, G. M., E. Reyes-Maldonado, L. Quevedo-Corona, N. Paniagua-Castro, G. Escalona-Cardoso, and M. E. Jaramillo-Flores. 2016. The prothrombotic state associated with obesity-induced hypertension is reduced by cocoa and its main flavanols. Food Funct. 7:4880–88.
  • Rains, T. M., S. Agarwal, and K. C. Maki. 2011. Antiobesity effects of green tea catechins: A mechanistic review. J Nutr Biochem. 22:1–7.
  • Rao, P. V., and S. H. Gan. 2014. Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med. 2014:642942.
  • Ríos-Hoyo, A., M. J. Cortés, H. Ríos-Ontiveros, E. Meaney, G. Ceballos, and G. Gutiérrez-Salmeán. 2015. Obesity, metabolic syndrome, and dietary therapeutical approaches with a special focus on nutraceuticals (polyphenols): A mini-review. Int J Vitam Nutr Res. 84:113–23.
  • Roberfroid, M. B. 2000. Concepts and strategy of functional food science: the European perspective. Am J Clin Nutr. 71:1660S–4S; discussion 1674S-5S.
  • Roh, C., and U. Jung. 2012. Screening of crude plant extracts with anti-obesity activity. International Journal of Molecular Sciences. 13:1710–1719.
  • Rothwell, J. A., J. Perez-Jimenez, V. Neveu, A. Medina-Remon, N. M'hiri, P. Garcia-Lobato, C. Manach, C. Knox, R. Eisner, D. S. Wishart, and A. Scalbert. 2013. Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford). 2013:bat070.
  • Saito, M., T. Yoneshiro, and M. Matsushita. 2016. Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans. Best Pract Res Clin Endocrinol Metab. 30:537–47.
  • Sanz, M., B. F. Simón, E. Cadahía, E. Esteruelas, A. M. Muñoz, T. Hernández, I. Estrella, and E. Pinto. 2012. LC-DAD/ESI-MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage. Journal of Mass Spectrometry. 47:905–18.
  • Sartorius, T., A. Peter, N. Schulz, A. Drescher, I. Bergheim, J. Machann, F. Schick, D. Siegel-Axel, A. Schürmann, and C. Weigert. 2014. Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PloS one. 9:e92358.
  • Scalbert, A., L. Brennan, O. Fiehn, T. Hankemeier, B. S. Kristal, B. van Ommen, E. Pujos-Guillot, E. Verheij, D. Wishart, and S. Wopereis. 2009. Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics. 5:435.
  • Schreckinger, M. E., J. Wang, G. Yousef, M. A. Lila, and E. Gonzalez de Mejia. 2010. Antioxidant capacity and in vitro inhibition of adipogenesis and inflammation by phenolic extracts of Vaccinium floribundum and Aristotelia chilensis. J Agric Food Chem. 58:8966–76.
  • Schwander, B., M. Hiligsmann, M. Nuijten, and S. Evers. 2016. Systematic review and overview of health economic evaluation models in obesity prevention and therapy. Expert Rev Pharmacoecon Outcomes Res. 16:561–70.
  • Sergent, T., J. Vanderstraeten, J. Winand, P. Beguin, and Y. Schneider. 2012. Phenolic compounds and plant extracts as potential natural anti-obesity substances. Food Chem. 135:68–73.
  • Shen, Y., S. J. Song, N. Keum, and T. Park. 2014. Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis. Evid Based Complement Alternat Med. 2014:971890.
  • Soliman, M. M., H. F. Attia, S. A. El-Shazly, and O. M. Saleh. 2012. Biomedical effects of cinnamon extract on obesity and diabetes relevance in Wistar rats. Am J Biochem Mol Biol. 2:133–45.
  • Sørensen, L. B., and A. Astrup. 2011. Eating dark and milk chocolate: a randomized crossover study of effects on appetite and energy intake. Nutrition & diabetes. 1:e21.
  • Sudeep, H., and K. S. Prasad. 2014. Computational studies on the antiobesity effect of polyphenols from pomegranate leaf. J.Chem.Pharm.Res. 6:278–81.
  • Suzuki, T., M. Pervin, S. Goto, M. Isemura, and Y. Nakamura. 2016. Beneficial effects of tea and the green tea catechin epigallocatechin-3-gallate on obesity. Molecules. 21(10):1305.
  • Takahashi, M., Y. Takahashi, K. Takahashi, F. N. Zolotaryov, K. S. Hong, R. Kitazawa, K. Iida, Y. Okimura, H. Kaji, and S. Kitazawa. 2008. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett. 582:573–78.
  • Tomé-Carneiro, J., M. Gonzálvez, M. Larrosa, F. J. García-Almagro, F. Avilés-Plaza, S. Parra, M. J. Yáñez-Gascón, J. A. Ruiz-Ros, M. T. García-Conesa, and F. A. Tomás-Barberán. 2012. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Molecular nutrition & food research. 56:810–21.
  • Tominaga, Y., K. Nakagawa, T. Mae, M. Kitano, S. Yokota, T. Arai, H. Ikematsu, and S. Inoue. 2009. Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: A randomized, double-blind, placebo-controlled study. Obesity Research & Clinical Practice. 3:169–78.
  • Trayhurn, P., and I. S. Wood. 2004. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 92:347–55.
  • Trayhurn, P. 2017. Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity. Biochimie. 134:62–70.
  • Tsigos, C., V. Hainer, A. Basdevant, N. Finer, M. Fried, E. Mathus-Vliegen, D. Micic, M. Maislos, G. Roman, Y. Schutz, H. Toplak, B. Zahorska-Markiewicz, and Obesity Management Task Force of the European Association for the Study of Obesity. 2008. Management of obesity in adults: European clinical practice guidelines. Obes Facts. 1:106–16.
  • Uchiyama, S., Y. Taniguchi, A. Saka, A. Yoshida, and H. Yajima. 2011. Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo. Nutrition. 27:287–92.
  • Vafa, M. R., F. Mohammadi, F. Shidfar, M. S. Sormaghi, I. Heidari, B. Golestan, and F. Amiri. 2012. Effects of Cinnamon Consumption on Glycemic Status, Lipid Profile and Body Composition in Type 2 Diabetes Patients. International journal of preventive medicine. 3:531–6.
  • Valls, R., E. Llauradó, S. Fernández-Castillejo, F. Puiggrós, R. Solà, L. Arola, and A. Pedret. 2016. Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial. Phytomedicine. 23:1451–61.
  • van Kruijsdijk, R. C., E. van der Wall, and F. L. Visseren. 2009. Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev. 18:2569–78.
  • Vasudeva, N., N. Yadav, and S. K. Sharma. 2012. Natural products: a safest approach for obesity. Chinese journal of integrative medicine. 18:473–80.
  • Velderrain-Rodríguez, G., H. Palafox-Carlos, A. Wall-Medrano, J. Ayala-Zavala, C. O. Chen, M. Robles-Sánchez, H. Astiazaran-García, E. Alvarez-Parrilla, and G. González-Aguilar. 2014. Phenolic compounds: their journey after intake. Food & function. 5:189–97.
  • Villalpando-Arteaga, E. V., E. Mendieta-Condado, H. Esquivel-Solís, A. A. Canales-Aguirre, F. J. Gálvez-Gastélum, J. C. Mateos-Díaz, J. A. Rodríguez-González, and A. L. Márquez-Aguirre. 2013. Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice. Food & function. 4:618–26.
  • Visioli, F., C. A. D. L. Lastra, C. Andres-Lacueva, M. Aviram, C. Calhau, A. Cassano, M. D'Archivio, A. Faria, G. Favé, and V. Fogliano. 2011. Polyphenols and human health: a prospectus. Crit Rev Food Sci Nutr. 51:524–46.
  • Vuong, Q. V. 2014. Epidemiological evidence linking tea consumption to human health: a review. Crit Rev Food Sci Nutr. 54:523–36.
  • Wakil, S. J. 1989. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry. 28:4523–30.
  • Wang, Y., B. Avula, N. D. Nanayakkara, J. Zhao, and I. A. Khan. 2013. Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food supplements in the United States. J Agric Food Chem. 61:4470–4476.
  • Wang, S., N. Moustaid-Moussa, L. Chen, H. Mo, A. Shastri, R. Su, P. Bapat, I. Kwun, and C-. Shen. 2014. Novel insights of dietary polyphenols and obesity. J Nutr Biochem. 25:1–18.
  • Westerterp-Plantenga, M. S., M. P. Lejeune, and E. M. Kovacs. 2005. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obesity. 13:1195–04.
  • Williams, D. J., D. Edwards, I. Hamernig, L. Jian, A. P. James, S. K. Johnson, and L. C. Tapsell. 2013. Vegetables containing phytochemicals with potential anti-obesity properties: A review. Food Res Int. 52:323–33.
  • Witkowska, A. M., M. E. Zujko, A. Waśkiewicz, K. M. Terlikowska, and W. Piotrowski. 2015. Comparison of Various Databases for Estimation of Dietary Polyphenol Intake in the Population of Polish Adults. Nutrients. 7:9299–08.
  • Wolfram, S., Y. Wang, and F. Thielecke. 2006. Anti-obesity effects of green tea: From bedside to bench. Mol Nutr Food Res. 50:176–87.
  • World Health Organization. 2015. sede Web. Obesity and overweight fact sheet. 2016.
  • World Health Organization. 2000. Obesity: preventing and managing the global epidemic. World Health Organization. WHO Technical Report Series 894:1–252.
  • Yeop Han, C., A. Y. Kargi, M. Omer, C. K. Chan, M. Wabitsch, K. D. O'Brien, T. N. Wight, and A. Chait. 2010. Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes. 59:386–96.
  • Zebisch, K., V. Voigt, M. Wabitsch, and M. Brandsch. 2012. Protocol for effective differentiation of 3T3-L1 cells to adipocytes. Anal Biochem. 425:88–90.
  • Zeyda, M., and T. M. Stulnig. 2009. Obesity, inflammation, and insulin resistance–a mini-review. Gerontology. 55:379–86.
  • Zhang, X., B. Huang, S. Choi, and J. Seo. 2012. Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation. Nutrition research and practice. 6:286–93.
  • Ziegenfuss, T. N., J. E. Hofheins, R. W. Mendel, J. Landis, and R. A. Anderson. 2006. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. Journal of the International Society of Sports Nutrition. 3:1.
  • Zulet, M. A., S. Navas-Carretero, D. Lara y Sánchez, I. Abete, J. Flanagan, N. Issaly, P. Fança-Berthon, A. Bily, M. Roller, and J. A. Martinez. 2014. A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: A longitudinal, randomized, crossover, double-blind, placebo-controlled nutritional intervention study. Phytomedicine. 21:1162–69.

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