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Reviews

Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

ORCID Icon, &
Pages 3456-3467 | Received 09 May 2018, Accepted 26 Jun 2018, Published online: 16 Oct 2018

References

  • Achuthan, A. A., R. K. Duary, A. Madathil, H. Panwar, H. Kumar, V. K. Batish, and S. Grover. 2012. Antioxidative potential of lactobacilli isolated from the gut of Indian people. Molecular Biology Reports 39(8):7887–97.
  • Afify, A.,. M. R. El-Moneim, R. M. Romeilah, S. I. M. Sultan, and M. M. Hussein. 2012. Antioxidant activity and biological evaluations of probiotic bacteria strains. International Journal of Academic Research 4(6):138–9.
  • Aguilar-Toalá, J. E., R. Garcia-Varela, H. S. Garcia, V. Mata-Haro, A. F. González-Córdova, B. Vallejo-Cordoba, and A. Hernández-Mendoza. 2018. Postbiotics: an evolving term within the functional foods field. Trends in Food Science and Technology 75:105–14.
  • Altonsy, M. O., S. C. Andrews, and K. M. Tuohy. 2010. Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: Mediation by the mitochondrial pathway. International Journal of Food Microbiology 137(2-3):190–203.
  • Ambalam, P., M. Raman, R. K. Purama, and M. Doble. 2016. Probiotics, prebiotics and colorectal cancer prevention. Best Practice & Research: Clinical Gastroenterology 30(1):119–31.
  • Annuk, H., J. Shchepetova, T. Kullisaar, E. Songisepp, M. Zilmer, and M. Mikelsaar. 2003. Characterization of intestinal lactobacilli as putative probiotic candidates. Journal of Applied Microbiology 94(3):403–12.
  • Ashraf, R., and N. P. Shah. 2013. Immune system stimulation by probiotic microorganisms. Critical Reviews in Food Science and Nutrition 54(7):938–56.
  • Awaisheh, S. S., M. M. Obeidat, H. J. Al-Tamimi, A. M. Assaf, J. M. EL-Quadah, J. M. Al-khaza’leh, and R. J. Rahahle. 2016. In vitro cytotoxic activity of probiotic bacterial cell extracts against Caco-2 and HRT-18 colorectal cancer cells. Milk Science International 69:27–31.
  • Azam, R., S. Ghafouri-Fard, M. Tabrizi, M. H. Modarressi, R. Ebrahimzadeh-Vesal, M. Daneshvar, M. B. Mobasheri, and E. Motevaseli. 2014. Lactobacillus acidophilus and Lactobacillus crispatus culture supernatants downregulate expression of cancer-testis genes in the MDA-MB-231 cell line. Asian Pacific Journal of Cancer Prevention 15(10):4255–9.
  • Badel, S., T. Bernardi, and P. Michaud. 2011. New perspectives for lactobacilli exopolysaccharides. Biotechnology Advances 29(1):54–66.
  • Baldwin, C., M. Millette, D. Oth, M. T. Ruiz, F. M. Luquet, and M. Lac-Roix. 2010. Probiotic Lactobacillus acidophilus and L. casei mix sensitize colorectal tumoral cells to 5-fluorouracil-induced apoptosis. Nutrition and Cancer 62(3):371–8.
  • Caggianiello, G., M. Kleerebezem, and G. Spano. 2016. Exopolysaccharides produced by lactic acid bacteria: from health-promoting benefits to stress tolerance mechanisms. Applied Microbiology and Biotechnology 100(9):3877–86.
  • Chen, C.-C., W.-C. Lin, M.-S. Kong, H. N. Shi, W. A. Walker, C.-Y. Lin, C.-T. Huang, Y.-C. Lin, S.-M. Jung, and T.-Y. Lin. 2012. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic Colon cancer and extra-intestinal tissue. British Journal of Nutrition 107(11):1623–34.
  • Chen, W., F. Liu, Z. Ling, X. Tong, and C. Xiang. 2012. Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PLoS ONE 7(6):e39743.
  • Coakley, M., M. C. Johnson, E. McGrath, S. Rahman, R. P. Ross, G. F. Fitzgerald, R. Devery, and C. Stanton. 2006. Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human Colon SW480 and HT-29 cancer cells. Nutrition and Cancer 56(1):95–102.
  • Daniluk, U., M. Alifier, and M. Kaczmarski. 2012. Probiotic-induced apoptosis and its potential relevance to mucosal inflammation of gastrointestinal tract. Advances in Medical Sciences 57(2):175–82.
  • Darendelioglu, E., M. Ciftci, and G. Baydas. 2017. The apoptotıc effects of SCFAs from Lactobacillus reuteri on (HT-29) human Colon cancer cells. Turkish Nature and Science Journal 6:11–9.
  • Davalli, P., G. Marverti, A. Lauriola, and D. D’Arca. 2018. Targeting oxidatively induced DNA damage response in cancer: opportunities for novel cancer therapies. Oxidative Medicine and Cellular Longevity 2018:1. Article ID: 2389523.
  • Deepak, V., S. Ramachandran, R. M. Balahmar, S. R. K. Pandian, S. D. Sivasubramaniam, H. Nellaiah, and K. Sundar. 2016. In vitro evaluation of anticancer properties of exopolysaccharides from Lactobacillus acidophilus in Colon cancer cell lines. In. In Vitro Cellular & Developmental Biology - Animal 52(2):163–73.
  • Di Luccia, B., N. Manzo, L. Baccigalupi, V. Calabrò, E. Crescenzi, E. Ricca, and A. Pollice. 2013. Lactobacillus gasseri SF1183 affects intestinal epithelial cell survival and growth. PLoS One 8(7):e69102.
  • dos Reis, S. A., L. L. da Conceição, N. P. Siqueira, D. D. Rosa, L. L. da Silva, M. do Carmo, and G. Peluzio. 2017. Review of the mechanisms of probiotic actions in the prevention of colorectal cancer. Nutrition Research (New York, N.Y.) 37:1–19.
  • El-Adawi, H. I., M. A. Khalil, M. M. El-Sheekh, N. M. El-Deeb, and M. Z. Hussein. 2012. Cytotoxicity assay and antioxidant activities of the lactic acid bacterial strains. African Journal of. Microbiology Research 6(8):1700–12.
  • Fan, J., K. A. Krautkramer, J. L. Feldman, and J. M. Denu. 2015. Metabolic regulation of histone post-translational modifications. ACS Chemical Biology 10(1):95–108.
  • Food and Agriculture Organization 2007. FAO technical meeting on prebiotics: Food quality and standards service (AGNS), food and agriculture organization of the united nations (FAO); FAO technical meeting report. Rome, Italy: FAO.
  • Food and Agriculture Organization 2002. Guidelines for the evaluation of probiotics in food; report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. London: FAO.
  • Garcia-Mendoza, A., J. Liebana, A. Castillo, A. de la Higuera, and J. Gutierrez. 1993. Post-hydrogen peroxide effect in peroxidogenic oral streptococci. Microbial Ecology in Health and Disease 6(1):17–22.
  • Gibson, P. R., O. Rosella, A. J. Wilson, J. M. Mariadason, K. Rickard, K. Byron, and D. Barkla. 1994. Colonic epithelial cell activation and the paradoxical effects of butyrate. Carcinogenesis 20(4):539–44.
  • Gowri, S., and G. A. Ranjan. 2011. Anti-oxidative potential of probiotic bacteria from Indian fermented food. IJRAP 2(3):983–6.
  • Grover, S., H. M. Rashmi, A. K. Srivastava, and V. K. Batish. 2012. Probiotics for human health-new innovations and emerging trends. Gut Pathogens 4(1):15
  • Haghshenas, B., Y. Nami, M. Haghshenas, N. Abdullah, R. Rosli, D. Radiah, and A. Yari Khosroushahi. 2015. Bioactivity characterization of Lactobacillus strains isolated from dairy products. Open Microbiology 4(5):803–13.
  • Hasannejad Bibalan, M., M. Eshaghi, M. Rohani, M. Esghaei, D. Darban-Sarokhalil, M. R. Pourshafie, and M. Talebi. 2017. Isolates of Lactobacillus plantarum and L. reuteri display greater antiproliferative and antipathogenic activity than other Lactobacillus isolates. Journal of Medical Microbiology 66(10):1416–20.
  • Hibberd, A. A., A. Lyra, A. C. Ouwehand, P. Rolny, H. Lindegren, L. Cedgard, and Y. Wettergren. 2017. Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention. BMJ Open Gastroenterology 4(1):e000145.
  • Hidalgo-Cantabrana, C.,. S. Delgado, L. Ruiz, P. Ruas-Madiedo, B. Sanchez, and A. Margolles. 2017. Bifidobacteria and their health-promoting effects. Microbiology Spectrum 5(3)
  • Hill, C., F. Guarner, G. Reid, G. R. Gibson, D. J. Merenstein, B. Pot, L. Morelli, R. B. Canani, H. J. Flint, S. Salminen, et al. 2014. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology 11(8):506–14.
  • Hirayama, K., and J. Rafter. 2000. The role of probiotic bacteria in cancer prevention. Microbes and Infection 2(6):681–6.
  • Igarashi, K., and K. Kashiwagi. 2010. Modulation of cellular function by polyamines. The International Journal of Biochemistry & Cell Biology 42(1):39–51.
  • Iyer, C., A. Kosters, G. Sethi, A. B. Kunnumakkara, B. B. Aggarwal, and J. Versalovic. 2008. Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. Cellular Microbiology 10(7):1442–52.
  • Kadidraredd, R. H., V. Mathakala, and U. M. Devi Palempalli. 2016. Therapeutic activity of conjugated linoleic acids synthesized by Lactobacillus plantarum. International Journal of Pharma and Bio Sciences 7(4):215–23.
  • Kahouli, I., M. Malhotra, M. Alaoui-Jamali, and S. Prakash. 2015. In-vitro characterization of the anti-cancer activity of the probiotic bacterium Lactobacillus fermentum NCIMB 5221 and potential against colorectal cancer cells. Journal of Cancer Science and Therapy 7:224–35.
  • Khailova, L., S. K. Mount Patrick, K. M. Arganbright, M. D. Halpern, T. Kinouchi, and B. Dvorak. 2010. Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis. American Journal of Physiology—Gastrointestinal and Liver Physiology 299(5):G1118–27.
  • Kim, J. Y., H. J. Woo, Y. S. Kim, and H. J. Lee. 2002. Screening for antiproliferative effects of cellular components from lactic acid bacteria against human cancer cell lines. Biotechnology Letters 24:1431–6.
  • Kim, J. U., Y. Kim, K. S. Han, S. Oh, K. Y. Whang, J. N. Kim, and S. H. Kim. 2006a. Function of cell-bound and released exopolysaccharides produced by Lactobacillus rhamnosus ATCC 9595. Journal of Microbiology and Biotechnology 16:939–45.
  • Kim, H. S., S. G. Jeong, J. S. Ham, H. S. Chae, J. M. Lee, and C. N. Ahn. 2006. Antioxidative and probiotic properties of Lactobacillus gasseri NLRI-312 isolated from Korean infant feces. Asian-Australasian Journal of Animal Sciences 19(9):1335–41.
  • Kim, J. E., J. Y. Kim, K. W. Lee, and H. J. Lee. 2007. Cancer chemopreventive effects of lactic acid bacteria. Journal of Microbiology and Biotechnology 17(8):1227–35.
  • Kobatake, E., H. Nakagawa, T. Seki, and T. Miyazaki. 2017. Protective effects and functional mechanisms of Lactobacillus gasseri SBT2055 against oxidative stress. PLoS One 12(5):e0177106.
  • Koller, V. J., B. Marian, R. Stidl, A. Nersesyan, H. Winter, T. Simić, G. Sontag, and S. Knasmüller. 2008. Impact of lactic acid bacteria on oxidative DNA damage in human derived Colon cells. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 46(4):1221–9.
  • Kullisaar, T., E. Songisepp, and M. Zilmer. 2012. Probiotics and oxidative stress. In Oxidative stress – environmental induction and dietary antioxidants, ed. L. Volodymyr, INTECH Open Science. Rijeka, Croatia: University Campus STeP Ri Slavka Krautzeka. https://www.intechopen.com/books/oxidative-stress-environmental-induction-and-dietary-antioxidants/probiotics-and-oxidative-stress.
  • Kumar, R. S., P. Kanmani, N. Yuvaraj, K. A. Paari, V. Pattukumar, C. Thirunavukkarasu, and V. Arul. 2012. Lactobacillus plantarum AS1 isolated from South Indian fermented food kallappam suppress 1,2-dimethylhydrazine (DMH)-induced colorectal cancer in male wistar rats. Applied Biochemistry and Biotechnology 166(3):620–31.
  • Kumar, M., R. Nagpal, V. Verma, A. Kumar, N. Kaur, R. Hemalatha, S. K. Gautam, and B. Singh. 2013. Probiotic metabolites as epigenetic targets in the prevention of colon cancer. Nutrition Reviews 71(1):23–34.
  • Kumar, K. S., N. Sastry, H. Polaki, and V. Mishra. 2015. Colon cancer prevention through probiotics: an overview. Journal of Cancer Science and Therapy 7:081–92.
  • Kurhan, Ş., and I. Çakir. 2017. Lactic acid bacteria mediated apoptosis induction: Natural way of Colon cancer cells’ inhibition. Proceedings 1(10):1041.
  • Kushgulova, A., S. Saduakhasova, S. Kozkhakmetov, G. Shakhabayeva, I. Tynybayeva, T. Nurgozhin, F. Marotta, and Z. Zhumadilov. 2014. Antioxidant activity of the probiotic consortium in vitro. Central Asian Journal of Global Health 2(1/2):55–60.
  • Kyung Lee, D., S. Jang, M. J. Kim, J. H. Kim, M. J. Chung, K. J. Kim, and N. J. Ha. 2008. Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines. BMC Cancer 8(1):310.
  • Lin, M. Y., and F. J. Chang. 2000. Antioxidative effect of intestinal bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356. Digestive Diseases and Sciences 45:1617–22.
  • Lin, M. Y., and C. L. Yen. 1999. Antioxidative ability of lactic acid bacteria. Journal of Agricultural and Food Chemistry 47(4):1460–6.
  • Linn, Y. H., K. K. Thu, and N. H. H. Win. 2018. Effect of probiotics for the prevention of acute radiation-induced diarrhoea among cervical cancer patients: a randomized double-blind placebo-controlled study. Probiotics Antimicrob. Proteins: 1–10. doi: 10.1007/s12602-018-9408-9
  • Linsalata, M., F. Russo, P. Berloco, A. M. Valentini, M. L. Caruso, C. De Simone, M. Barone, L. Polimeno, and A. Di Leo. 2005. Effects of probiotic bacteria (VSL#3) on the polyamine biosynthesis and cell proliferation of normal colonic mucosa of rats. In Vivo 19(6):989–95.
  • Liu, C. T., F. J. Chu, C. C. Chou, and R. C. Yu. 2011a. Antiproliferative and anticytotoxic effects of cell fractions and exopolysaccharides from Lactobacillus casei 01. Mutation Research 721(2):157–62.
  • Liu, C. F., K. C. Tseng, S. S. Chiang, B. H. Lee, W. H. Hsu, and T. M. Pan. 2011b. Immunomodulatory and antioxidant potential of lactobacillus exopolysaccharides. Journal of the Science of Food and Agriculture 91(12):2284–91.
  • Los, M., S. Wesselborg, and K. Schulze-Osthoff. 1999. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice. Immunity 10(6):629–39.
  • Matsuki, T., T. Pédron, B. Regnault, C. Mulet, T. Hara, and P. J., Sansonetti. 2013. Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve. PLoS ONE 8(4):e63053.
  • Medina, V., J. J. Afonso, H. Alvarez-Arguelles, C. Hernández, and F. González. 1998. Sodium butyrate inhibits carcinoma development in 1,2-dimethylhydrazine-induced rat Colon cancer. Journal of Parenteral and Enteral Nutrition 22(1):14–7.
  • Mikelsaar, M., and M. Zilmer. 2009. Lactobacillus fermentum ME-3—an antimicrobial and antioxidative probiotic. Microbial Ecology in Health and Disease 21(1):1–27.
  • Mishra, V., C. Shah, N. Mokashe, R. Chavan, H. Yadav, and J. Prajapati. 2015. Probiotics as potential antioxidants: a systematic review. Journal of Agricultural and Food Chemistry 63(14):3615–26.
  • Nakatsu, G., X. Li, H. Zhou, J. Sheng, S. H. Wong, W. K. Wu, S. C. Ng, H. Tsoi, Y. Dong, and N. Zhang. 2015. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nature Communications 6(1):8727.
  • Nardone, G., D. Compare, E. Liguori, V. Di Mauro, A. Rocco, M. Barone, A. Napoli, D. Lapi, M. R. Iovene, and A. Colantuoni. 2010. Protective effects of Lactobacillus paracasei F19 in a rat model of oxidative and metabolic hepatic injury. American Journal of Physiology-Gastrointestinal and Liver Physiology 299(3):G669–76.
  • Nistal, E., N. Fernández-Fernández, S. Vivas, and J. L. Olcoz. 2015. Factors determining colorectal cancer: The role of the intestinal microbiota. Frontiers in Oncology 5 article 220.
  • Nouri, Z., F. Karami, N. Neyazi, M. H. Modarressi, R. Karimi, M. R. Khorramizadeh, B. Taheri, and E. Motevaseli. 2016. Dual anti-metastatic and anti-proliferative activity assessment of two probiotics on HeLa and HT-29 cell lines. Cell Journal 18(2):127–34.
  • Nowak, A., and K. Śliżewska. 2014. β-Glucuronidase And β-glucosidase activity and human fecal water genotoxicity in the presence of probiotic lactobacilli and the heterocyclic aromatic amine IQ in vitro. Environmental Toxicology and Pharmacology 37(1):66–73.
  • Nowak, A., K. Śliżewska, J. Błasiak, and Z. Libudzisz. 2014. The influence of Lactobacillus casei DN 114 001 on the activity of faecal enzymes and genotoxicity of faecal water in the presence of heterocyclic aromatic amines. Anaerobe 30:129–36.
  • Nowak, A., A. Czyżowska, and M. Stańczyk. 2015. Protective activity of probiotic bacteria against 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PhIP) – an in vitro study. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure &Amp; Risk Assessment 32(11):1927–38.
  • Nowak, A., K. Śliżewska, and A. Otlewska. 2015. Antigenotoxic activity of lactic acid bacteria, prebiotics, and products of their fermentation against selected mutagens. Regulatory Toxicology and Pharmacology 73(3):938–46.
  • Nozari, S., M. Mohammadzadeh, Y. Faridvand, A. Tockmechi, A. Movassaghpour, and J. Abdolalizadeh. 2016. The study of extracellular protein fractions of probiotic candidate bacteria on cancerous cell line. Archives of Iranian Medicine 19(11):779–85.
  • Orlando, A., C. Messa, M. Linsalata, A. Cavallini, and F. Russo. 2009. Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines. Immunopharmacology and Immunotoxicology 31(1):108–16.
  • Orlando, A., M. G. Refolo, C. Messa, L. Amati, P. Lavermicocca, V. Guerra, and F. Russo. 2012. Antiproliferative and proapoptotic effects of viable or heat-killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 gastric and DLD-1 Colon cell lines. Nutrition and Cancer 64(7):1103–11.
  • Pessi, T., Y. Sütas, M. Saxelin, H. Kallioinen, and E. Isolauri. 1999. Antiproliferative effects of homogenates derived from five strains of candidate probiotic bacteria. Applied and Environmental Microbiology 65(11):4725–8.
  • Rains, J. L., and S. K. Jain. 2011. Oxidative stress, insulin signaling, and diabetes. Free Radical Biology & Medicine 50(5):567–75.
  • Reid, G. 2016. Probiotics: definition, scope and mechanisms of action. Best Practice & Research. Clinical Gastroenterology 30(1):17–25.
  • Ruas-Madiedo, P., M. Medrano, N. Salazar, C. G. Reyes-Gavilán, P. F. Pérez, and A. G. Abraham. 2010. Exopolysaccharides produced by lactobacillus and bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells. Journal of Applied Microbiology 109(6):2079–86.
  • Russo, F., M. Linsalata, and A. Orlando. 2014. Probiotics against neoplastic transformation of gastric mucosa: Effects on cell proliferation and polyamine metabolism. World Journal of Gastroenterology 20(37):13258–72.
  • Russo, F., A. Orlando, M. Linsalata, A. Cavallini, and C. Messa. 2007. Effects of Lactobacillus rhamnosus GG on the cell growth and polyamine metabolism in HGC-27 human gastric cancer cells. Nutr. Cancer 59(1):106–14.
  • Lebeer, S., I. J. J. Claes, T. L. A. Verhoeven, J. Vanderleyden, and S. C. J. De Keersmaecker. 2011. Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine. Microbial Biotechnology 4(3):368–74.
  • Sadeghi-Aliabadi, H., F. Mohammadi, H. Fazeli, and M. Mirlohi. 2014. Effects of Lactobacillus plantarum A7 with probiotic potential on colon cancer and normal cells proliferation in comparison with a commercial strain. The Iranian Journal of Basic Medical Science 17:815–9.
  • Sevda, E. R., A. T. Koparal, and M. Kivanc. 2015. Cytotoxic effect of various lactic acid bacteria on Caco-2 cells. Turkish Journal of Biology 39:23–30.
  • Shen, Q., N. Shang, and P. Li. 2011. In vitro and in vivo antioxidant activity of Bifidobacterium animalis 01 isolated from centenarians. Current Microbiology 62(4):1097–103.
  • Shokryazdan, P., M. Faseleh Jahromi, F. Bashokouh, Z. Idrus, and B. Boo Liang. 2017. Antiproliferation effects and antioxidant activity of two new Lactobacillus strains. Brazilian Journal of Food Technology 21(0):e2016064.
  • Shyu, P. T., G. G. Oyong, and E. C. Cabrera. 2014. Cytotoxicity of probiotics from Philippine commercial dairy products on cancer cells and the effect on expression of cfos and cjun early apoptotic-promoting genes and interleukin-1β and tumor necrosis factor-α proinflammatory cytokine genes. BioMed Research International 2014:1. Article ID:491740.
  • Soltan Dallal, M. M., M. Mojarrad, F. Boghbani, R. Raoofian, J. Mardaneh, and Z. Salehipour. 2015. Effect of probiotic Lactobacillus acidophilus and Lactobacillus casei on the behavior of colorectal tumor cells (Caco-2). Archives of Iranian Medicine 18(3):167–72.
  • Sungur, T., B. Aslim, C. Karaaslan, and B. Aktas. 2017. Impact of exopolysaccharides (EPSs) of Lactobacillus gasseri strains isolated from human vagina on cervical tumor cells (HeLa). Anaerobe 47:137–44.
  • Sunkata, R., J. Herring, L. T. Walker, and M. Verghese. 2014. Chemopreventive potential of probiotics and prebiotics. Food and Nutrition Sciences 05(18):1800–9.
  • Thirabunyanon, M., and P. Hongwittayakorn. 2013. Potential probiotic lactic acid bacteria of human origin induce antiproliferation of colon cancer cells via synergic actions in adhesion to cancer cells and short-chain fatty acid bioproduction. Applied Biochemistry and Biotechnology 169(2):511–25.
  • Tiptiri-Kourpeti, A., K. Spyridopoulou, V. Santarmaki, G. Aindelis, E. Tompoulidou, E. E. Lamprianidou, G. Saxami, P. Ypsilantis, E. S. Lampri, and C Simopoulos. 2016. Lactobacillus casei exerts anti-proliferative effects accompanied by apoptotic cell death and up-regulation of trail in Colon carcinoma cells. PLoS ONE 11(2):e0147960.
  • Trachootham, D., J. Alexandre, and P. Huang. 2009. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?. Nature Reviews Drug Discovery 8(7):579–91.
  • Trojan, N., and P. Satora. 2017. Probiotics and their potential antioxidative activity. Postępy Mikrobiologii 56 (1):18–27.
  • Uccello, M., G. Malaguarnera, F. Basile, V. D’agata, M. Malaguarnera, G. Bertino, M. Vacante, F. Drago, and A. Biondi. 2012. Potential role of probiotics on colorectal cancer prevention. BMC Surgery 12(Suppl 1):S35.
  • Valko, M., D. Leibfritz, J. Moncol, M. T. Cronin, M. Mazur, and J. Telser. 2007. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry & Cell Biology 39(1):44–84.
  • Vong, L., R. J. Lorentz, A. Assa, M. Glogauer, and P. M. Sherman. 2014. Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps. Journal of Immunology 192(4):1870–77.
  • Wan, Y., Y. Xin, C. Zhang, D. Wu, D. Ding, L. Tang, L. Owusu, J. Bai, and W. Li. 2014. Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human Colon cancer cells and induce apoptosis through a caspase 3 dependent pathway. Oncology Letters 7(5):1738–42.
  • Wang, S., X. Han, L. Zhang, Y. Zhang, H. Li, and Y. Jiao. 2018. Whole peptidoglycan extracts from the Lactobacillus paracasei M5 strain exert anticancer activity in vitro. BioMed Research International 2018:1. Article ID:2871710.
  • Wasilewska, E., D. Złotkowska, and M. Pijagin. 2013. The role of intestinal microflora and probiotic bacteria in prophylactic and development of colorectal cancer. Postępy Higieny i Medycyny Doświadczalnej 67:837–47.
  • World Cancer Research Fund International 2017. CUP—Continuous Update Project. Analysing research on cancer prevention and survival. https://www.wcrf.org/sites/default/files/Colorectal-Cancer-2017-Report.pdf, 06.04.2018.
  • Xu, C., Y. Xia, L. Huang, H. Chen, X. Zhang, and Q. Yao. 2016. Role of gut probiotic microbiota in the apoptosis of gastrointestinal cancer. Oxidation Communication 39:214–22.
  • Yang, B., H. Gao, C. Stanton, R. P. Ross, H. Zhang, Y. Q. Chen, H. Chen, and W. Chen. 2017. Bacterial conjugated linoleic acid production and their applications. Progress in Lipid Research 68:26–36.
  • Yao, Y.,. T. Suo, R. Andersson, Y. Cao, C. Wang, J. Lu, and E. Chui. 2017. Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas. The Cochrane Database of Systematic Reviews 1:CD003430
  • Waris, G., and H. Ahsan. 2006. Reactive oxygen species: Role in the development of cancer and various chronic conditions. Journal of Carcinogenesis 5(14):14–8.
  • Zerrouki, M., and F. Benkaci-Ali. 2018. DFT study of the mechanisms of nonenzymatic DNA repair by phytophenolic antioxidants. Journal of Molecular Modeling 24(4):78
  • Zhong, L., X. Zhang, and M. Covasa. 2014. Emerging roles of lactic acid bacteria in protection against colorectal cancer. World Journal of Gastroenterology 20(24):7878–86.
  • Zhou, X., T. Hong, Q. Yu, S. Nie, D. Gong, T. Xiong, and M. Xie. 2017. Exopolysaccharides from Lactobacillus plantarum NCU116 induce c-Jun dependent Fas/Fasl-mediated apoptosis via TLR2 in mouse intestinal epithelial cancer cells. Scientific Reports 7(1):14247.
  • Zilmer, M., U. Soomets, A. Rehema, and Ü. Langel. 2005. The glutathione system as an attractice therapeutic target. Drug Design Reviews—Online 2(2):121–27.

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