1,270
Views
44
CrossRef citations to date
0
Altmetric
Reviews

Vitamin D status, oxidative stress, and inflammation in children and adolescents: A systematic review

, , &

References

  • Alvarez-Diaz, S., N. Valle, J. M. Garcia, C. Pena, J. M. Freije, V. Quesada, A. Astudillo, F. Bonilla, C. López-Otín, and A. Muñoz. 2009. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human Colon cancer cells. Journal of Clinical Investigation 119:2343–2358. doi:10.1172/JCI37205.
  • Anatoliotakis, N., S. Deftereos, G. Bouras, G. Giannopoulos, D. Tsounis, C. Angelidis, A. Kaoukis, and C. Stefanadis. 2013. Myeloperoxidase: Expressing inflammation and oxidative stress in cardiovascular disease. Current Topics in Medicinal Chemistry 13 (2):115–138. doi:10.2174/1568026611313020004.
  • Balbin, M., A. Hall, A. Grubb, R. W. Mason, C. López-Otín, and M. Abrahamson. 1994. Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. Journal of Biological Chemistry 269:23156–23162.
  • Barbosa, K. B. F., N. M. B. Costa, R. C. G. Alfenas, S. O. De Paula, V. P. R. Minim, and J. Bressan. 2010. Estresse oxidativo: Conceito, implicações e fatores modulatórios. Revista de Nutrição 23 (4):629–643. doi:10.1590/S1415-52732010000400013.
  • Berridge, M. J. 2017. Vitamin D deficiency and diabetes. The Biochemical Journal 474 (8):1321–1332.
  • Bezrati, I., M. K. Ben Fradj, N. Ouerghi, M. Feki, A. Chaouachi, and N. Kaabachi. 2016. Vitamin D inadequacy is widespread in Tunisian active boys and is related to diet but not to adiposity or insulin resistance. Libyan Journal of Medicine 11 (1):31258. doi:10.3402/ljm.v11.31258.
  • Borges, M. C., L. A. Martini, and M. M. Rogero. 2011. Current perspectives on vitamin D, immune system and chronic diseases. Nutrition 27 (4):399–404. doi:10.1016/j.nut.2010.07.022.
  • Boucher-Berry, C., P. W. Speiser, D. E. Carey, S. P. Shelov, S. Accacha, I. Fennoy, R. Rapaport, Y. Espinal, and M. Rosenbaum. 2012. Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children. Journal of Bone and Mineral Research 27 (2):283–293.
  • Braegger, C., C. Campoy, V. Colomb, T. Decsi, M. Domellof, M. Fewtrell, I. Hojsak, W. Mihatsch, C. Molgaard, R. Shamir, et al. 2013. Vitamin D in the healthy European paediatric population. Journal of Pediatric Gastroenterology and Nutrition 56:692–701. doi:10.1097/MPG.0b013e31828f3c05.
  • Calvo, M. S., and C. J. Lamberg-Allardt. 2017. Vitamin D research and public health nutrition: A current perspective. Public Health Nutrition 20 (10):1713–1717. doi:10.1017/S1368980017001835.
  • Cashman, K. D., M. Kiely, M. Kinsella, R. A. Durazo-Arvizu, L. Tian, Y. Zhang, A. Lucey, A. Flynn, M. J. Gibney, H. W. Vesper, et al. 2013. Evaluation of vitamin D standardization program protocols for standardizing serum 25-hydroxyvitamin D data: A case study of the program’s potential for national nutrition and health surveys. The American Journal of Clinical Nutrition 97 (6):1235–1242. doi:10.3945/ajcn.112.057182.
  • Codoñer-Franch, P., L. Boix-García, R. Simó-Jordá, C. Del Castillo-Villaescusa, J. Maset-Maldonado, and V. Valls-Bellés. 2010. Is obesity associated with oxidative stress in children? International Journal of Pediatric Obesity 5 (1):56–63. doi:10.3109/17477160903055945.
  • Codoñer-Franch, P., S. Tavárez-Alonso, R. Murria-Estal, J. Megías-Vericat, M. Tortajada-Girbés, and E. Alonso-Iglesias. 2011. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis 215 (2):475–480. doi:10.1016/j.atherosclerosis.2010.12.035.
  • Codoñer-Franch, P., S. Tavárez-Alonso, R. Simó-Jordá, P. Laporta-Martín, A. Carratalá-Calvo, and E. Alongo-Iglesias. 2012a. Vitamin D status is linked to biomarkers of oxidative stress, Inflammation, and endothelial activation in obese children. The Journal of Pediatrics 161 (5):848–854. doi:10.1016/j.jpeds.2012.04.046.
  • Codoñer-Franch, P., A. Navarro-Ruiz, M. Fernández-Ferri, A. Arilla-Codoñer, E. Ballester-Asensio, and V. Valls-Bellés. 2012b. A matter of fat: Insulin resistance and oxidative stress. Pediatric Diabetes 13 (5):392–399. doi:10.1111/j.1399-5448.2011.00847.x.
  • Colotta, F., B. Jansson, and F. Bonelli. 2017. Modulation of inflammatory and immune responses by vitamin D. Journal of Autoimmunity 85:78–97.
  • DeLuca, H. F. 2004. Overview of general physiologic features and functions of vitamin D. The American Journal of Clinical Nutrition 80 (6 Suppl):1689S–1696S.
  • Fitzpatrick, A. M., Y. Park, L. A. Brown, and D. P. Jones. 2014. Children with severe asthma have unique oxidative stress-associated metabolomic profiles. The Journal of Allergy and Clinical Immunology 133 (1):258–261. doi:10.1016/j.jaci.2013.10.012.
  • Gaksch, M., R. Jorde, G. Grimnes, R. Joakimsen, H. Schirmer, T. Wilsgaard, E. B. Mathiesen, I. Njølstad, M. L. Løchen, W. März, et al. 2017. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from the European consortium. PLoS One 12:e017091.
  • Ganji, V., X. Zhang, N. Shaikh, and V. Tangpricha. 2011. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001–2006. The American Journal of Clinical Nutrition 94 (1):225–233. doi:10.3945/ajcn.111.013516.
  • Gannagé-Yared, M. H., R. Chedid, S. Khalife, E. Azzi, F. Zoghbi, and G. Halaby. 2009. Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population. European Journal of Endocrinology 160 (6):965–971. doi:10.1530/EJE-08-0952.
  • George, N., T. P. Kumar, S. Antony, S. Jayanarayanan, and C. S. Paulose. 2012. Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats. British Journal of Nutrition 108 (8):1410–1418. doi:10.1017/S0007114511006830.
  • Ghezzo, A., P. Visconti, P. M. Abruzzo, A. Bolotta, C. Ferreri, G. Gobbi, G. Malisardi, S. Manfredini, M. Marini, L. Nanetti, et al. 2013. Oxidative stress and erythrocyte membrane alterations in children with autism: Correlation with clinical features. PLoS One 8 (6):e66418. doi:10.1371/journal.pone.0066418.
  • Gilardini, L., L. Pasqualinotto, S. Di Matteo, K. Caffetto, M. Croci, A. Girola, and C. Invitti. 2011. Factors associated with early atherosclerosis and arterial calcifications in young subjects with a benign phenotype of obesity. Obesity (Silver Spring) 19 (8):1684–1689. doi:10.1038/oby.2010.342.
  • Haffner, S. M. 2006. The metabolic syndrome: Inflammation, diabetes mellitus, and cardiovascular disease. The American Journal of Cardiology 97 (2A):3A–11A. doi:10.1016/j.amjcard.2005.11.010.
  • Halliwell, B., and M. Whiteman. 2004. Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? British Journal of Pharmacology 142 (2):231–255.
  • Holick, M. F. 2004. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. American Journal of Clinical Nutrition 80 (6 Suppl):1678–1688.
  • Holick, M. F. 2006. High prevalence of vitamin D inadequacy and implications for health. Mayo Clinic Proceedings 81 (3):353–373.
  • Holick, M. F. 2007. Vitamin D deficiency. The New England Journal of Medicine 357 (3):266–281.
  • Institute of Medicine (IOM); Food and Nutrition Board; Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. 2011. Dietary reference intakes for calcium and vitamin D, eds. A. C. Ross, C. L. Taylor, A. L. Yaktine, and H. B. Del Valle. Washington, DC: National Academies Press.
  • Ismail, M. M., T. A. Abdel Hamid, A. A. Ibrahim, and H. Marzouk. 2017. Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus. Archives of Medical Science: AMS 13 (4):738–744.
  • Jobs, E., E. Ingelsson, U. Riserus, E. Nerpin, M. Jobs, J. Sundstrom, S. Basu, A. Larsson, L. Lind, and J. Arnlov. 2011. Association between serum cathepsin S and mortality in older adults. JAMA 306 (10):1113–1121. doi:10.1001/jama.2011.1246.
  • Keaney, J. F., Jr, M. G. Larson, R. S. Vasan, P. W. Wilson, I. Lipinska, D. Corey, J. M. Massaro, P. Sutherland, J. A. Vita, and E. J. Benjamin. 2003. Obesity and systemic oxidative stress clinical correlates of oxidative stress in the Framingham study. Arteriosclerosis, Thrombosis, and Vascular Biology 23 (3):434–439. doi:10.1161/01.ATV.0000058402.34138.11.
  • Kelly, A., L. J. Brooks, S. Dougherty, D. C. Carlow, and B. S. Zemel. 2011. A cross-sectional study of vitamin D and insulin resistance in children. Archives of Disease in Childhood 96 (5):447–452.
  • Korda, M., R. Kubant, S. Patton, and T. Malinski. 2008. Leptin-induced endothelial dysfunction in obesity. American Journal of Physiology-Heart and Circulatory Physiology 295 (4):H1514–H1H21. doi:10.1152/ajpheart.00479.2008.
  • McCarty, M. F., and C. A. Thomas. 2003. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Medical Hypotheses 61 (5–6):535–542. doi:10.1016/S0306-9877(03)00227-5.
  • McDonnell, S. L., C. Baggerly, C. B. French, L. L. Baggerly, C. F. Garland, E. D. Gorham, J. M. Lappe, and R. P. Heaney. 2016. Serum 25-hydroxyvitamin D concentrations ≥40 ng/ml are associated with >65% lower cancer risk: Pooled analysis of randomized trial and prospective cohort study. PLoS One 11 (4):e0152441.
  • Milagres, L. C., N. P. Rocha, F. M. Albuquerque, A. P. P. Castro, M. S. Filgueiras, M. C. Pessoa, M. C. G. Peluzio, and J. F. Novaes. 2017a. Sedentary behavior is associated with lower serum concentrations of vitamin D in Brazilian children. Public Health 152:75–78. doi:10.1016/j.puhe.2017.07.021.
  • Milagres, L. C., N. P. Rocha, M. S. Filgueiras, F. M. Albuquerque, A. P. P. Castro, M. C. Pessoa, M. C. G. Peluzio, and J. F. Novaes. 2017b. Vitamin D insufficiency/deficiency is associated with insulin resistance in Brazilian children, regardless of body fat distribution. Public Health Nutrition 20 (16):2878–2886. doi:10.1017/S136898001700194X.
  • Misra, M., D. Pacaud, A. Petryk, P. F. Collett-Solberg, M. Kappy, and Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. 2008. Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics 122 (2):398–417. doi:10.1542/peds.2007-1894.
  • Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman, and Prisma Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine 6 (7):e1000097. doi:10.1371/journal.pmed.1000097.
  • Mokhtar, R. R., M. F. Holick, F. Sempértegui, J. K. Griffiths, B. Estrella, L. L. Moore, M. P. Fox, and D. H. Hamer. 2018. Vitamin D status is associated with underweight and stunting in children aged 6–36 months residing in the Ecuadorian Andes. Public Health Nutrition 21 (11):1974–1985. doi: 10.1017/S1368980017002816.
  • Munns, C. F., N. Shaw, M. Kiely, B. L. Specker, T. D. Thacher, K. Ozono, T. Michigami, D. Tiosano, M. Z. Mughal, O. Mäkitie, et al. 2016. Global consensus recommendations on prevention and management of nutritional rickets. The Journal of Clinical Endocrinology and Metabolism 101 (2):394–415., doi:10.1210/jc.2015-2175.
  • Mutt, S. J., E. Hyppönen, J. Saarnio, M. R. Järvelin, and K. H. Herzig. 2014. Vitamin D and adipose tissue-more than storage. Frontiers in Physiology 5:228.
  • Nagpal, S., S. Na, and R. Rathnachalam. 2005. Noncalcemic actions of vitamin D receptor ligands. Endocrine Reviews 26 (5):662–687.
  • Nimitphong, H., S. Chanprasertyothin, W. Jongjaroenprasert, and B. Ongphiphadhanakul. 2009. The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance. Endocrine 36 (2):205–210. doi:10.1007/s12020-009-9216-9.
  • Olusi, S. 2002. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. International Journal of Obesity 26 (9):1159–1164. doi:10.1038/sj.ijo.0802066.
  • Pacifico, L., C. Anania, J. F. Osborn, F. Ferraro, E. Bonci, E. Olivero, and C. Chiesa. 2011. Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. European Journal of Endocrinology 165 (4):603–611. doi:10.1530/EJE-11-0545.
  • Palacios, C., and L. Gonzalez. 2014. Is vitamin D deficiency a major global public health problem? The Journal of Steroid Biochemistry and Molecular Biology 144:138–145. doi:10.1016/j.jsbmb.2013.11.003.
  • Petersen, R. A., S. M. Dalskov, L. B. Sørensen, M. F. Hjorth, R. Andersen, I. Tetens, H. Krarup, C. Ritz, A. Astrup, K. F. Michaelsen., et al. 2015. Vitamin D status is associated with cardiometabolic markers in 8–11-year-old children, independently of body fat and physical activity. British Journal of Nutrition 114 (10):1647–1655. doi:10.1017/S0007114515003372.
  • Pirgon, O., H. Bilgin, F. Çekmez, H. Kurku, and B. N. Dündar. 2013. Association between insulin resistance and oxidative stress parameters in obese adolescents with non-alcoholic fatty liver disease. Journal of Clinical Research in Pediatric Endocrinology 5:33–39.
  • Reyman, M., A. A. Verrijn Stuart, M. van Summeren, M. Rakhshandehroo, R. Nuboer, F. K. de Boer, H. J. van den Ham, E. Kalkhoven, B. Prakken, and H. S. Schipper. 2014. Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity. International Journal of Obesity 38 (1):46–52. doi:10.1038/ijo.2013.75.
  • Rodríguez-Rodríguez, E., A. Aparicio, P. Andrés, and R. M. Ortega. 2014. Moderate vitamin D deficiency and inflammation related markers in overweight/obese schoolchildren. International Journal for Vitamin and Nutrition Research 84 (1–2):98–107. doi:10.1024/0300-9831/a000197.
  • Sanchez-Niño, M. D., M. Bozic, E. Córdoba-Lanús, P. Valcheva, O. Gracia, M. Ibarz, E. Fernandez, J. F. Navarro-Gonzalez, A. Ortiz, and J. M. Valdivielso. 2012. Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy. American Journal of Physiology-Renal Physiology 302 (6):F647–F657. doi:10.1152/ajprenal.00090.2011.
  • Singh, J., E. D. Merrill, P. B. Sandesara, L. Schoeneberg, H. Daí, and G. Raghuveer. 2015. Vitamin D, low-grade inflammation and cardiovascular risk in young children: A pilot study. Pediatric Cardiology 36 (7):1338–1343. doi:10.1007/s00246-015-1162-0.
  • Stach, K., A. I. Kalsch, X. D. Nguyen, E. Elmas, S. Kralev, S. Lang, C. Weiss, M. Borggrefe, and T. Kalsch. 2011. 1α,25-dihydroxyvitamin D3 attenuates platelet activation and the expression of VCAM-1 and MT1-MMP in human endothelial cells. Cardiology 118 (2):107–115. doi:10.1159/000327547.
  • Tiosano, D., G. Wildbaum, V. Gepstein, O. Verbitsky, Y. Weisman, N. Karin, and A. Eztioni. 2013. The role of vitamin D receptor in innate and adaptive immunity: A study in hereditary vitamin D-resistant rickets patients. The Journal of Clinical Endocrinology and Metabolism 98 (4):1685–1693. doi:10.1210/jc.2012-3858.
  • Tohari, A. M., X. Zhou, and X. Shu. 2016. Protection against oxidative stress by vitamin D in cone cells. Cell Biochemistry and Function 34 (2):82–94.
  • Uberti, F., D. Lattuada, V. Morsanuto, U. Nava, G. Bolis, G. Vacca, D. F. Squarzanti, C. Cisari, and C. Molinari. 2014. Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. The Journal of Clinical Endocrinology and Metabolism 99 (4):1367–1374. doi:10.1210/jc.2013-2103.
  • Vaidya, A., J. P. Forman, P. C. Underwood, P. N. Hopkins, G. H. Williams, L. H. Pojoga, and J. S. Williams. 2011. The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men. European Journal of Endocrinology 164 (6):995–1002. doi:10.1530/EJE-11-0025.
  • Vimaleswaran, K. S., D. J. Berry, C. Lu, E. Tikkanen, S. Pilz, L. T. Hiraki, J. D. Cooper, Z. Dastani, R. Li, D. K. Houston, et al. 2013. Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medicine 10 (2):e1001383. doi:10.1371/journal.pmed.1001383.
  • von Elm, E., D. G. Altman, M. Egger, S. J. Pocock, P. C. Gøtzsche, J. P. Vandenbroucke, and STROBE Initiative. 2007. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Epidemiology 18 (6):800–804. doi:10.1097/EDE.0b013e3181577654.
  • Wharton, B., and N. Bishop. 2003. Rickets. Lancet 362 (9393):1389–1400.
  • White, J. H. 2008. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infection and Immunity 76 (9):3837–3843.
  • Wilkinson, R. D., R. Williams, C. J. Scott, and R. E. Burden. 2015. Cathepsin S: Therapeutic, diagnostic, and prognostic potential. Biological Chemistry 396 (8):867–882.
  • Yin, K., and D. K. Agrawal. 2014. Vitamin D and inflammatory diseases. Journal of Inflammation Research 7:69–87.
  • Yu, A., J. Kim, O. Kwon, S. Y. Oh, J. Kim, and Y. J. Yang. 2013. The association between serum 25-hydroxyvitamin D concentration and consumption frequencies of vitamin d food sources in korean adolescents. Clinical Nutrition Research 2 (2):107–114. doi:10.7762/cnr.2013.2.2.107.
  • Zhang, H.-Q., J.-H. Teng, Y. Li, X.-X. Li, Y.-H. He, X. He, and C.-H. Sun. 2014. Vitamin D status and its association with adiposity and oxidative stress in schoolchildren. Nutrition 30 (9):1040–1044.
  • Zhang, Y., D. Y. Leung, B. N. Richers, Y. Liu, L. K. Remigio, D. W. Riches, and E. Goleva. 2012. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. Journal of Immunology 188 (5):2127–2135. doi:10.4049/jimmunol.1102412.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.