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Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential

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References

  • Adams, C. A. 2010. The probiotic paradox: Live and dead cells are biological response modifiers. Nutrition Research Reviews 23 (1):37–46.
  • Agarwal, P., P. Khatri, B. Billack, W.-K. Low, and J. Shao. 2014. Oral delivery of glucagon like peptide-1 by a recombinant Lactococcus lactis. Pharmaceutical Research 31 (12):3404–3414.
  • Al-Salami, H., G. Butt, J. P. Fawcett, I. G. Tucker, S. Golocorbin-Kon, and M. Mikov. 2008. Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics 33 (2):101–106.
  • Amar, J., C. Chabo, A. Waget, P. Klopp, C. Vachoux, L. G. Bermúdez-Humarán, N. Smirnova, M. Bergé, T. Sulpice, and S. Lahtinen. 2011. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: Molecular mechanisms and probiotic treatment. EMBO Molecular Medicine 3 (9):559–572.
  • American Diabetes Association (ADA). 2016. Classification and diagnosis of diabetes. Diabetes Care 39 (Suppl. 1):S13–S22.
  • Andersson, U., C. Bränning, S. Ahrné, G. Molin, J. Alenfall, G. Onning, M. Nyman, and C. Holm. 2010. Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse. Beneficial Microbes 1 (2):189–196.
  • Andreasen, A. S., N. Larsen, T. Pedersen-Skovsgaard, R. M. G. Berg, K. Møller, K. D. Svendsen, M. Jakobsen, and B. K. Pedersen. 2010. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. British Journal of Nutrition 104 (12):1831–1838.
  • Arora, T., J. Anastasovska, G. Gibson, K. Tuohy, R. K. Sharma, J. Bell, and G. Frost. 2012. Effect of Lactobacillus acidophilus NCDC 13 supplementation on the progression of obesity in diet-induced obese mice. The British Journal of Nutrition 108 (8):1382–1389.
  • Asemi, Z., A. Khorrami-Rad, S.-A. Alizadeh, H. Shakeri, and A. Esmaillzadeh. 2014. Effects of synbiotic food consumption on metabolic status of diabetic patients: A double-blind randomized cross-over controlled clinical trial. Clinical Nutrition 33 (2):198–203.
  • Asemi, Z., Z. Zare, H. Shakeri, S. S. Sabihi, and A. Esmaillzadeh. 2013. Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Annals of Nutrition and Metabolism 63 (1–2):1–9.
  • Ashraf, R., and N. P. Shah. 2014. Immune system stimulation by probiotic microorganisms. Critical Reviews in Food Science and Nutrition 54 (7):938–956.
  • Akbari, V., F. Hendijani, A. Feizi, J. Varshosaz, Z. Fakhari, S. Morshedi, and S. A. Mostafavi. 2016. Efficacy and safety of oral insulin compared to subcutaneous insulin: A systematic review and Meta-analysis. Journal of Endocrinological Investigation 39 (2):215–225.
  • Aluwong, T., J. Ayo, A. Kpukple, and O. Oladipo. 2016. Amelioration of hyperglycaemia, oxidative stress and dyslipidaemia in Alloxan-induced diabetic Wistar rats treated with probiotic and vitamin C. Nutrients 8 (5):151.
  • Balakumar, M., D. Prabhu, C. Sathishkumar, P. Prabu, N. Rokana, R. Kumar, S. Raghavan, A. Soundarajan, S. Grover, V. K. Batish, et al. 2018. Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice. European Journal of Nutrition 57 (1):279–295.
  • Bayat, A., F. Azizi-Soleiman, M. Heidaribeni-Beni, A. Feizi A, B. Iraj, R. Ghiasvand, and G. Askari. 2016. Effect of Cucurbita ficifolia and probiotic yogurt consumption on blood glucose, lipid profile, and inflammatory marker in type 2 diabetes. International Journal of Preventive Medicine 7 (1):30.
  • Bejar, W., K. Hamden, R. Ben Salah, and H. Chouayekh. 2013. Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats. Anaerobe 24:4–11.
  • Bekiari, E., C. Rizava, E. Athanasiadou, K. Papatheodorou, A. Liakos, T. Karagiannis, M. Mainou, M. Rika, P. Boura, A. Tsapas, et al. 2016. Systematic review and Meta-analysis of vildagliptin for treatment of type 2 diabetes. Endocrine 52 (3):458–480.
  • Bicsak, T. A., B. Walsh, and M. Fineman. 2017. Metformin-associated lactic acidosis (MALA): Moving towards a new paradigm. Diabetes, Obesity and Metabolism 19 (11):1499–1501.
  • Blandino, G., R. Inturri, F. Lazzara, M. Di Rosa, and L. Malaguarnera. 2016. Impact of gut microbiota on diabetes mellitus. Diabetes & Metabolism 42 (5):303–315.
  • Brunkwall, L., and M. Orho-Melander. 2017. The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: From current human evidence to future possibilities. Diabetologia 60 (6):943–951.
  • Canchaya, C., M. J. Claesson, G. F. Fitzgerald, D. van Sinderen, and P. W. O'Toole. 2006. Diversity of the genus lactobacillus revealed by comparative genomics of five species. Microbiology 152 (11):3185–3196.
  • Cani, P. D., J. Amar, M. A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A. M. Neyrinck, F. Fava, K. M. Tuohy, C. Chabo, et al. 2007. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56 (7):1761.
  • Cani, P. D., and N. M. Delzenne. 2009. The role of the gut microbiota in energy metabolism and metabolic disease. Current Pharmaceutical Design 15 (13):1546–1558.
  • Cani, P. D., S. Possemiers, T. Van de Wiele, Y. Guiot, A. Everard, O. Rottier, L. Geurts, D. Naslain, A. Neyrinck, D. M. Lambert, et al. 2009. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58 (8):1091–1103.
  • Chaudhury, A., C. Duvoor, V. S. Reddy Dendi, S. Kraleti, A. Chada, R. Ravilla, A. Marco, N. S. Shekhawat, M. T. Montales, K. Kuriakose, et al. 2017. Clinical review of antidiabetic drugs: Implications for type 2 diabetes mellitus management. Frontiers in Endocrinology 8:6.
  • Chen, J. J., R. Wang, X.-F. Li, and R.-L. Wang. 2011. Bifidobacterium longum supplementation improved high-fat-fed-induced metabolic syndrome and promoted intestinal reg I gene expression. Experimental Biology and Medicine 236 (7):823–831.
  • Chen, J. J., R. Wang, X.-F. Li, and R.-L. Wang. 2012. Bifidobacterium adolescentis supplementation ameliorates visceral fat accumulation and insulin sensitivity in an experimental model of the metabolic syndrome. British Journal of Nutrition 107 (10):1429–1434.
  • Chen, P., Q. Zhang, H. Dang, X. Liu, F. Tian, J. Zhao, Y. Chen, H. Zhang, and W. Chen. 2014. Antidiabetic effect of Lactobacillus casei CCFM0412 on mice with type 2 diabetes induced by a high-fat diet and streptozotocin. Nutrition 30 (9):1061–1068.
  • Didari, T., S. Solki, S. Mozaffari, S. Nikfar, and M. Abdollahi. 2014. A systematic review of the safety of probiotics. Expert Opinion on Drug Safety 13 (2):227–239.
  • Delzenne, N. M., P. D. Cani, A. Everard, A. M. Neyrinck, and L. B. Bindels. 2015. Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia 58 (10):2206–2217.
  • Druart, C., M. Alligier, N. Salazar, A. M. Neyrinck, and N. M. Delzenne. 2014. Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties. Advances in Nutrition (Bethesda, Md.) 5 (5):624S–633S.
  • D'Souza, R., D. R. Pandeya, M. Rahman, H. Seo Lee, J. K. Jung, and S. T. Hong. 2012. Genetic engineering of Lactococcus lactis to produce an amylase inhibitor for development of an anti-diabetes biodrug. New Microbiologica 35 (1):35–42.
  • Dujic, T., A. Causevic, T. Bego, M. Malenica, Z. Velija-Asimi, E. R. Pearson, and S. Semiz. 2016. Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with type 2 diabetes. Diabetic Medicine: A Journal of the British Diabetic Association 33 (4):511–514.
  • Ejtahed, H. S., J. Mohtadi-Nia, A. Homayouni-Rad, M. Niafar, M. Asghari-Jafarabadi, V. Mofid, and A. Akbarian-Moghari. 2011. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. Journal of Dairy Science 94 (7):3288–3294.
  • Ejtahed, H. S., J. Mohtadi-Nia, A. Homayouni-Rad, M. Niafar, M. Asghari-Jafarabadi, and V. Mofid. 2012. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition 28 (5):539–543.
  • Everard, A., S. Matamoros, L. Geurts, N. M. Delzenne, and P. D. Cani. 2014. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. MBio 5 (3):e01011–e01014.
  • Evivie, S. E., G.-C. Huo, J. O. Igene, and X. Bian. 2017. Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics. Food & Nutrition Research 61 (1):1318034.
  • Ferrannini, E., and R. A. DeFronzo. 2015. Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. European Heart Journal 36 (34):2288–2296.
  • Firouzi, S., H. A. Majid, A. Ismail, N. A. Kamaruddin, and M.-Y. Barakatun-Nisak. 2017. Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: A randomized controlled trial. European Journal of Nutrition 56 (4):1535–1550.
  • Firouzi, S., B. N. Mohd-Yusof, H. A. Majid, A. Ismail, and N. A. Kamaruddin. 2015. Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: A randomized controlled trial. BMC Complementary & Alternative Medicine 15 (1):433.
  • Gao, K., C. Wang, L. Liu, X. Dou, J. Liu, L. Yuan, W. Zhang, and H. Wang. 2015. Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide. Journal of Microbiology, Immunology and Infection 50 (5):700–713.
  • Gill, H., and J. Prasad. 2008. Probiotics, immunomodulation, and health benefits. Advances in Experimental Medicine and Biology 606:423–454.
  • Global Burden of Disease (GBD). 2015. Disease and injury incidence and prevalence, collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the Global Burden of Disease Study. Lancet 388 (10053):545–1602.
  • Gomes, A. C., A. A. Bueno, R. G. M. de Souza, and J. F. Mota. 2014. Gut microbiota, probiotics and diabetes. Nutrition Journal 13:60.
  • Guarino, E., L. Nigi, A. Patti, C. Fondelli, and F. Dotta. 2012. Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 13 (9):1377–1384.
  • Hadisaputro, S., Djokomoeljanto, R. R. Judiono, and M. H. Soesatyo. 2012. The effects of oral plain kefir supplementation on proinflammatory cytokine properties of the hyperglycemia Wistar rats induced by streptozotocin. Acta Medica Indonesiana 44 (2):100–104.
  • Hambridge, K. 2007. The management of lipohypertrophy in diabetes care. British Journal of Nursing (Mark Allen Publishing) 16 (9):520–524.
  • Hampe, C. S., and C. L. Roth. 2017. Probiotic strains and mechanistic insights for the treatment of type 2 diabetes. Endocrine 58 (2):1–21.
  • Hänninen, A., R. Toivonen, S. Pöysti, C. Belzer, H. Plovier, J. P. Ouwerkerk, R. Emani, P. D. Cani, and W. M. De Vos. 2018. Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice. Gut 67 (8):1445–1453.
  • He, C., Y. Shan, and W. Song. 2015. Targeting gut microbiota as a possible therapy for diabetes. Nutrition Research (New York, N.Y.) 35 (5):361–367.
  • He, X., C. M. Slupsky, J. W. Dekker, N. W. Haggarty, and B. Lönnerdal B. 2016. Integrated role of Bifidobacterium animalis subsp. lactis supplementation in gut microbiota, immunity, and metabolism of infant Rhesus monkeys. mSystems 1 (6):e00128-16.
  • Holscher, H. D., L. A. Czerkies, P. Cekola, R. Litov, M. Benbow, and S. Santema. et al. 2012. Bifidobacterium lactis bb12 enhances intestinal antibody response in formula-fed infants a randomized, double-blind, controlled trial. Journal of Parenteral & Enteral Nutrition 36 (1 Suppl):106S.
  • Honda, K., M. Moto, N. Uchida, F. He, and N. Hashizume. 2012. Anti-diabetic effects of lactic acid bacteria in normal and type 2 diabetic mice. Journal of Clinical Biochemistry and Nutrition 51 (2):96–101.
  • Hsieh, F.-C., C.-L. Lee, C.-Y. Chai, W.-T. Chen, Y.-C. Lu, and C.-S. Wu. 2013. Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. Nutrition & Metabolism 10 (1):35.
  • Huang, Y. J. 2013. The therapeutic effects of GLP-1 analogs-transformed bifidobacteria on T2DM mice by oral administration [Master thesis]. Southern Medical University. (In Chinese)
  • Hummel, S., K. Veltman, C. Cichon, U. Sonnenborn, and M. A. Schmidt. 2012. Differential targeting of the E-Cadherin/β-Catenin complex by gram-positive probiotic lactobacilli improves epithelial barrier function. Applied and Environmental Microbiology 78 (4):1140–1147.
  • Jia, L., D. Li, N. Feng, M. Shamoon, Z. Sun, L. Ding, H. Zhang, W. Chen, J. Sun, and Y. Q. Chen. 2017. Anti-diabetic effects of Clostridium butyricum CGMCC0313.1 through promoting the growth of gut butyrate-producing bacteria in type 2 diabetic mice. Scientific Reports 7 (1):7046.
  • Kahn, S. E., M. E. Cooper, and S. D. Prato. 2014. Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future. Lancet (London, England) 383 (9922):1068–1083.
  • Kang, H. J., and S. H. Im. 2015. Probiotics as an immune modulator. Journal of Nutritional Science and Vitaminology 61 (Suppl.):S103–S105.
  • Karaki, S.-I., R. Mitsui, H. Hayashi, I. Kato, H. Sugiya, T. Iwanaga, J. B. Furness, and A. Kuwahara. 2006. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell and Tissue Research 324 (3):353–360.
  • Karczewski, J., F. J. Troost, I. Konings, J. Dekker, M. Kleerebezem, R.-J. M. Brummer, and J. M. Wells. 2010. Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. American Journal of Physiology-Gastrointestinal and Liver Physiology 298 (6):G851–G859.
  • Kasińska, M. A., and J. Drzewoski. 2015. Effectiveness of probiotics in type 2 diabetes: A meta-analysis. Polskie Archiwum Medycyny Wewnetrznej 125 (11):803–813.
  • Kim, S.-H., C.-S. Huh, I.-D. Choi, J.-W. Jeong, H.-K. Ku, J.-H. Ra, T.-Y. Kim, G.-B. Kim, J.-H. Sim, and Y.-T. Ahn. 2014. The anti-diabetic activity of Bifidobacterium lactis HY8101 in vitro and in vivo. Journal of Applied Microbiology 117 (3):834–845.
  • Kim, S.-W., K.-Y. Park, B. Kim, E. Kim, and C.-K. Hyun. 2013. Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production. Biochemical and Biophysical Research Communications 431 (2):258–263.
  • Kim, W., and J. M. Egan. 2008. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacological Reviews 60 (4):470–512.
  • Lallès, J. P. 2016. Microbiota-host interplay at the gut epithelial level, health and nutrition. Journal of Animal Science and Biotechnology 7:66.
  • Le, T. K. C., T. Hosaka, T. T. T. Le, T. G. Nguyen, Q. B. Tran, T. H. H. Le, and X. D. Pham. 2014. Oral administration of Bifidobacterium spp. improves insulin resistance, induces adiponectin, and prevents inflammatory adipokine expressions. Biomedical Research 35 (5):303–310.
  • Le, T. K. C., T. Hosaka, T. T. Nguyen, A. Kassu, T. O. Dang, H. B. Tran, T. P. Pham, Q. B. Tran, T. H. H. Le, and X. D. Pham. 2015. Bifidobacterium species lower serum glucose, increase expressions of insulin signaling proteins, and improve adipokine profile in diabetic mice. Biomedical Research 36 (1):63–70.
  • Lee, E., S. R. Jung, and S. Y. Lee. 2018. Lactobacillus plantarum Strain Ln4 attenuates diet-induced obesity, insulin resistance, and changes in hepatic mRNA levels associated with glucose and lipid metabolism. Nutrients 10 (5):E643.
  • Lee, H. A., H. Kim, K.-W. Lee, and K.-Y. Park. 2015. Dead nano-sized Lactobacillus plantarum inhibits azoxymethane/dextran sulfate sodium-induced Colon cancer in Balb/c mice. Journal of Medicinal Food 18 (12):1400–1405.
  • Lee, H. A., H. Kim, K.-W. Lee, and K.-Y. Park. 2016. Dead Lactobacillus plantarum stimulates and skews immune responses toward T helper 1 and 17 polarizations in RAW 264.7 cells and mouse splenocytes. Journal of Microbiology and Biotechnology 26 (3):469–476.
  • Li, X., N. Wang, B. Yin, D. Fang, T. Jiang, S. Fang, J. Zhao, H. Zhang, G. Wang, W. Chen., et al. 2016a. Effects of Lactobacillus plantarum CCFM0236 on hyperglycaemia and insulin resistance in high-fat and streptozotocin-induced type 2 diabetic mice. Journal of Applied Microbiology 121 (6):1727–1736.
  • Li, X., Q. Xu, T. Jiang, S. Fang, G. Wang, J. Zhao, H. Zhang, and W. Chen. 2016b. A comparative study of the antidiabetic effects exerted by live and dead multi-strain probiotics in the type 2 diabetes model of mice. Food & Function 7 (12):4851–4860.
  • Lim, S.-M., J.-J. Jeong, K. H. Woo, M. J. Han, and D.-H. Kim. 2016. Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing Colon tight junction protein expression. Nutrition Research 36 (4):337–348.
  • Lindsay, K. L., M. Kennelly, M. Culliton, T. Smith, O. C. Maguire, F. Shanahan, L. Brennan, and F. M. McAuliffe. 2014. Probiotics in obese pregnancy do not reduce maternal fasting glucose: A double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study). The American Journal of Clinical Nutrition 99 (6):1432–1439.
  • Lu, Y.-C., L.-T. Yin, W.-T. Chang, and J.-S. Huang. 2010. Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats. Journal of Bioscience and Bioengineering 110 (6):709–715.
  • Maciel, F. R., G. R. Punaro, A. M. Rodrigues, C. S. B. Bogsan, M. M. Rogero, M. N. Oliveira, M. G. Mouro, and E. M. S. Higa. 2016. Immunomodulation and nitric oxide restoration by a probiotic and its activity in gut and peritoneal macrophages in diabetic rats. Clinical Nutrition (Edinburgh, Scotland) 35 (5):1066–1072.
  • Manaer, T., L. Yu, Y. Zhang, X.-J. Xiao, and X.-H. Nabi. 2015. Anti-diabetic effects of shubat in type 2 diabetic rats induced by combination of high-glucose-fat diet and low-dose streptozotocin. Journal of Ethnopharmacology 169:269–274.
  • Marazza, J. A., J. G. LeBlanc, G. S. de Giori, and M. S. Garro. 2013. Soymilk fermented with Lactobacillus rhamnosus CRL981 ameliorates hyperglycemia, lipid profiles and increases antioxidant enzyme activities in diabetic mice. Journal of Functional Foods 5 (4):1848–1853.
  • Marchesi, J. R., D. H. Adams, F. Fava, G. D. A. Hermes, G. M. Hirschfield, G. Hold, M. N. Quraishi, J. Kinross, H. Smidt, K. M. Tuohy, et al. 2016. The gut microbiota and host health: A new clinical frontier. Gut 65 (2):330–339.
  • Marques, T. M., E. Patterson, R. Wall, O. O'Sullivan, G. F. Fitzgerald, P. D. Cotter, T. G. Dinan, J. F. Cryan, R. P. Ross, C. Stanton, et al. 2016. Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model. Beneficial Microbes 7 (3):409–420.
  • Martin, F. P., Y. Wang, N. Sprenger, I. K. Yap, T. Lundstedt, P. Lek, S. Rezzi, Z. Ramadan, P. van Bladeren, L. B. Fay, et al. 2008. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Molecular Systems Biology 4:157.
  • Memarrast, F., S. Ghafouri-Fard, S. Kolivand, S. J. Nodooshan, N. Neyazi, E. Sadroddiny, and E. Motevaseli. 2017. Comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin-induced diabetic rats. Diabetes/Metabolism Research and Reviews 33 (7). doi: 10.1002/dmrr.2912.
  • Million, M., E. Angelakis, M. Paul, F. Armougom, L. Leibovici, and D. Raoult. 2012. Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microbial Pathogenesis 53 (2):100–108.
  • Mobini, R., V. Tremaroli, M. Ståhlman, F. Karlsson, M. Levin, M. Ljungberg, M. Sohlin, H. Bertéus Forslund, R. Perkins, F. Bäckhed, et al. 2016. Metabolic effects of Lactobacillus reuteri DSM 17938 in patients with type 2 diabetes: A randomized controlled trial. Diabetes, Obesity and Metabolism 19 (4):579.
  • Moroti, C., L. F. S. Magri, M. D. R. Costa, D. C. Cavallini, and K. Sivieri. 2012. Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus. Lipids in Health and Disease 11 (1):29.
  • Neef, A., and Y. Sanz. 2013. Future for probiotic science in functional food and dietary supplement development. Current Opinion in Clinical Nutrition and Metabolic Care 16 (6):679–687.
  • Nido, S. A., S. A. Shituleni, B. M. Mengistu, Y. Liu, A. Z. Khan, F. Gan, S. Kumbhar, and K. Huang. 2016. Effects of selenium-enriched probiotics on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in mice fed a high-fat diet. Biological Trace Element Research 171 (2):399–409.
  • Nikbakht, E., S. Khalesi, I. Singh, L. T. Williams, N. P. West, and N. Colson. 2016. Effect of probiotics and synbiotics on blood glucose: A systematic review and meta-analysis of controlled trials. European Journal of Nutrition 57 (1):95–106. doi: 10.1007/s00394-016-1300-3.
  • Okubo, T., N. Takemura, A. Yoshida, and K. Sonoyama. 2013. KK/Ta mice administered Lactobacillus plantarum strain No. 14 have lower adiposity and higher insulin sensitivity. Bioscience of Microbiota, Food and Health 32 (3):93–100.
  • O'Connor, L. M., M. A. Lentjes, R. N. Luben, K. T. Khaw, N. J. Wareham, and N. G. Forouhi. 2014. Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary. Diabetologia 57 (5):909–917.
  • Panwar, H., H. M. Rashmi, V. K. Batish, and S. Grover. 2013. Probiotics as potential biotherapeutics in the management of type 2 diabetes: Prospects and perspectives. Diabetes/Metabolism Research and Reviews 29 (2):103–112.
  • Park, D.-Y., Y.-T. Ahn, S.-H. Park, C.-S. Huh, S.-R. Yoo, R. Yu, M.-K. Sung, R. A. McGregor, and M.-S. Choi. 2013. Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS One 8 (3):e59470.
  • Park, K. Y., B. Kim, and C. K. Hyun. 2015. Lactobacillus rhamnosus GG improves glucose tolerance through alleviating ER stress and suppressing macrophage activation in db/db mice. Journal of Clinical Biochemistry and Nutrition 56 (3):240–246.
  • Park, T. H., M. S. Kim, and D. Y. Lee. 2016. Clinical and laboratory characteristics of childhood diabetes mellitus: A single-center study from 2000 to 2013. Chonnam Medical Journal 52 (1):64–69.
  • Pedersen, H. K., V. Gudmundsdottir, H. B. Nielsen, T. Hyotylainen, T. Nielsen, B. A. H. Jensen, K. Forslund, F. Hildebrand, E. Prifti, G. Falony, et al. 2016. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 535 (7612):376–381.
  • Pei, R., D. A. Martin, D. M. DiMarco, and B. W. Bolling. 2017. Evidence for the effects of yogurt on gut health and obesity. Critical Reviews in Food Science and Nutrition 57 (8):1569–1583.
  • Plaza-Diaz, J., C. Gomez-Llorente, L. Fontana, and A. Gil. 2014. Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics. World Journal of Gastroenterology 20 (42):15632–15649.
  • Punaro, G. R., F. R. Maciel, A. M. Rodrigues, M. M. Rogero, C. S. B. Bogsan, M. N. Oliveira, S. S. M. Ihara, S. R. R. Araujo, T. R. C. Sanches, L. C. Andrade, et al. 2014. Kefir administration reduced progression of renal injury in STZ-diabetic rats by lowering oxidative stress. Nitric Oxide 37:53–60.
  • Rad, A. H., S. Abbasalizadeh, S. Vazifekhah, F. Abbasalizadeh, T. Hassanalilou, P. Bastani, H.-S. Ejtahed, A.-R. Soroush, M. Javadi, A. M. Mortazavian, et al. 2017. The future of diabetes management by healthy probiotic microorganisms. Current Diabetes Reviews 13 (6):582–589.
  • Robert, S., and L. Steidler. 2014. Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the type 1 diabetes case. Microbial Cell Factories 13 (Suppl. 1):S11.
  • Samsom, M., T. Trivedi, O. Orekoya, and S. Vyas. 2016. Understanding the importance of gene and environment in the etiology and prevention of type 2 diabetes mellitus in high-risk populations. Oral Health Case Reports 2 (1):112.
  • Sandoval, D. 2008. CNS GLP-1 regulation of peripheral glucose homeostasis. Physiology & Behavior 94 (5):670–674.
  • Shakeri, H., H. Hadaegh, F. Abedi, M. Tajadadi-Ebrahimi, N. Mazroii, Y. Ghandi, and Z. Asemi. 2014. Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes. Lipids 49 (7):695–701.
  • Sluijs, I., N. G. Forouhi, J. W. Beulens, Y. T. van der Schouw, C. Agnoli, L. Arriola, B. Balkau, A. Barricarte, H. Boeing, H. B. Bueno-de-Mesquita, et al. 2012. The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC-InterAct Study. The American Journal of Clinical Nutrition 96 (2):382–390.
  • Simon, M.-C., K. Strassburger, B. Nowotny, H.t Kolb, P. Nowotny, V. Burkart, F. Zivehe, J.-H. Hwang, P. Stehle, G. Pacini, et al. 2015. Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: A proof of concept. Diabetes Care 38 (10):1827–1834.
  • Singh, S., R. K. Sharma, S. Malhotra, R. Pothuraju, and U. K. Shandilya. 2017. Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocin treated rats. Beneficial Microbes 8 (2):243–255.
  • Stenman, L. K., A. Waget, C. Garret, P. Klopp, R. Burcelin, and S. Lahtinen. 2014. Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Beneficial Microbes 5 (4):437–445.
  • Stenman, L. K., A. Waget, C. Garret, F. Briand, R. Burcelin, T. Sulpice, and S. Lahtinen. 2015. Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice. Diabetology & Metabolic Syndrome 7:75.
  • Suh, J. M., J. W. Jonker, M. Ahmadian, R. Goetz, D. Lackey, O. Osborn, Z. Huang, W. Liu, E. Yoshihara, T. H. van Dijk, et al. 2014. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 513 (7518):436–439.
  • Tabuchi, M., M. Ozaki, A. Tamura, N. Yamada, T. Ishida, M. Hosoda, and A. Hosono. 2003. Antidiabetic effect of lactobacillus GG in streptozotocin-induced diabetic rats. Bioscience, Biotechnology, and Biochemistry 67 (6):1421–1424.
  • Tajadadi-Ebrahimi, M., F. Bahmani, H. Shakeri, H. Hadaegh, M. Hijijafari, F. Abedi, and Z. Asemi. 2014. Effects of daily consumption of synbiotic bread on insulin metabolism and serum high-sensitivity C-reactive protein among diabetic patients: A double-blind, randomized, controlled clinical trial. Annals of Nutrition and Metabolism 65 (1):34–41.
  • Tajadadi-Ebrahimi, M., N. Sharifi, A. Farrokhian, F. Raygan, F. Karamali, R. Razzaghi, S. Taheri, and Z. Asemi. 2017. A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Experimental and Clinical Endocrinology & Diabetes 125 (1):21–27.
  • Tanaka, K., T. Tsukahara, T. Yanagi, S. Nakahara, O. Furukawa, H. Tsutsui, and S. Koshida. 2017. Bifidobacterium bifidum OLB6378 simultaneously enhances systemic and mucosal humoral immunity in low birth weight infants: A non-randomized study. Nutrients 9 (3):195.
  • Thrasher, J. 2017. Pharmacologic management of type 2 diabetes mellitus: Available therapies. The American Journal of Medicine 130 (6S):S4–S17.
  • Tian, F., L. Yu, Q. Zhai, Y. Xiao, Y. Shi, J. Jiang, X. Liu, J. Zhao, H. Zhang, W. Chen, et al. 2017. The therapeutic protection of a living and dead lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice. PLoS One 12 (4):e0175398.
  • Tian, P., B. Li, C. He, W. Song, A. Hou, S. Tian, X. Meng, K. Li, and Yujuan Shan. 2016. Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota. Food & Function 7 (9):3789–3797.
  • Tomaro-Duchesneau, C., S. Saha, M. Malhotra, M. L. Jones, A. Labbé, L. Rodes, I. Kahouli, and S. Prakash. 2014. Effect of orally administered Lactobacillus fermentum NCIMB 5221 on markers of metabolic syndrome: An in vivo analysis using ZDF rats. Applied Microbiology and Biotechnology 98 (1):115–126.
  • Tonucci, L. B, K. M. Olbrich dos Santos, C. L. De Luces Fortes Ferreira, S. M. R. Ribeiro, L. L. De Oliveira, and H. S. D. Martino. 2017a. Gut microbiota and probiotics: Focus on diabetes mellitus. Critical Reviews in Food Science and Nutrition 57 (11):2296–2309.
  • Tonucci, L. B., K. M. Olbrich dos Santos, L. Licursi de Oliveira, S. M. Rocha Ribeiro, and H. S. Duarte Martino. 2017b. Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo controlled study. Clinical Nutrition 36 (1):85–92.
  • Toshimitsu, T., S. Ozaki, J. Mochizuki, K. Furuichi, and Y. Asami. 2017. Effects of Lactobacillus plantarum strain OLL2712 culture conditions on the anti-inflammatory activities for murine immune cells and obese and type 2 diabetic mice. Applied and Environmental Microbiology 83 (7):e03001-16.
  • Trabelsi, M. S., S. Lestavel, B. Staels, and X. Collet. 2016. Intestinal bile acid receptors are key regulators of glucose homeostasis. Proceedings of the Nutrition Society 16:1–11.
  • Turton, M. D., D. O'Shea, I. Gunn, S. A. Beak, C. M. Edwards, K. Meeran, S. J. Choi, G. M. Taylor, M. M. Heath, P. D. Lambert, et al. 1996. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 (6560):69–72.
  • van Olden, C., A. K. Groen, and M. Nieuwdorp. 2015. Role of intestinal microbiome in lipid and glucose metabolism in diabetes mellitus. Clinical Therapeutics 37 (6):1172–1177.
  • Vilahur, G., S. López-Bernal, S. Camino, G. Mendieta, T. Padró, and L. Badimon. 2015. Lactobacillus plantarum CECT 7315/7316 intake modulates the acute and chronic innate inflammatory response. European Journal of Nutrition 54 (7):1161–1171.
  • Waddell, J. 2017. An update on type 2 diabetes management in primary care. Nurse Practitioner 42 (8):20–29.
  • Wallymahmed, M. E., P. Littler, C. Clegg, M. T. Haqqani, and I. A. Macfarlane. 2004. Nodules of fibrocollagenous scar tissue induced by subcutaneous insulin injections: A cause of poor diabetic control. Postgraduate Medical Journal 80 (950):732–733.
  • Wang, G., X. Li, J. Zhao, H. Zhang, and W. Chen. 2017. Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism. Food & Function 8 (9):3155–3164.
  • Wang, L.-Q., F. Zhao, F. Liu, and X.-C. Meng. 2013. Live/dead state is not the factor influencing adhesion ability of Bifidobacterium animalis KLDS2.0603. Journal of Microbiology 51 (5):584–589.
  • Wegmann, U., A. L. Carvalho, M. Stocks, and S. R. Carding. 2017. Use of genetically modified bacteria for drug delivery in humans: Revisiting the safety aspect. Scientific Reports 7 (1):2294.
  • Wei, P., Y. Yang, T. Li, Q. Ding, and H. Sun. 2015. A engineered Bifidobacterium longum secreting a bioactive penetratin-Glucagon-like peptide 1 fusion protein enhances Glucagon-like peptide 1 absorption in the intestine. Journal of Microbiology and Biotechnology. doi: 10.4014/jmb.1412.12030
  • Wu, R., C. Ma, X. Li, D. Huikun, J. Yanli, W. Yu, J. Pingzhe, W. Haisong, T. Peipei, L. Miao, et al. 2015. Construction of yeast strains expressing long-acting glucagon-like peptide-1 (GLP-1) and their therapeutic effects on type 2 diabetes mellitus mouse model. Yi Chuan 37 (2):183–191. (In Chinese)
  • Wu, X., C. Ma, L.Han, M. Nawaz, F. Gao, X. Zhang, P. Yu, C. Zhao, L. Li, A. Zhou, et al. 2010. Molecular characterisation of the faecal microbiota in patients with type II diabetes. Current Microbiology 61 (1):69–78.
  • Yadav, H., S. Jain, and P. R. Sinha. 2007. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition 23 (1):62–68.
  • Yadav, H., S. Jain, and P. R. Sinha. 2008. Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats. Journal of Dairy Research 75 (2):189–195.
  • Yadav, H., J.-H. Lee, J. Lloyd, P. Walter, and S. G. Rane. 2013. Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. Journal of Biological Chemistry 288 (35):25088–25097.
  • Yakovlieva, M., T. Tacheva, S. Mihaylova, R. Tropcheva, K. Trifonova, A. Toleкova, S. Danova, and T. Vlaykova. 2015. Influence of Lactobacillus brevis 15 and Lactobacillus plantarum 13 on blood glucose and body weight in rats after high-fructose diet. Beneficial Microbes 6 (4):505–512.
  • Yoo, J. Y., and S. S. Kim. 2016. Probiotics and prebiotics: Present status and future perspectives on metabolic disorders. Nutrients 8 (3):173.
  • Yun, S. I., H. O. Park, and J. H. Kang. 2009. Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes. Journal of Applied Microbiology 107 (5):1681–1686.
  • Zarfeshani, A., H. Khaza’ai, R. Mohd Ali, Z. Hambali, K. W. J. Wahle, and M. S. A. Mutalib. 2011. Effect of Lactobacillus casei on the production of pro-inflammatory markers in streptozotocin-induced diabetic rats. Probiotics and Antimicrobial Proteins 3 (3–4):168–174.
  • Zhang, L., Q. Qin, M. Liu, X. Zhang, F. He, and G. Wang. 2018. Akkermansia muciniphila can reduce the damage of gluco/lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin-induced diabetic rats. Pathogens and Disease 76 (4).
  • Zhang, Y., X. Sun, B. Icli, and M. W. Feinberg. 2017. Emerging roles for MicroRNAs in diabetic microvascular disease: Novel targets for therapy. Endocrine Reviews 38 (2):145–168.
  • Zhao, S., W. Liu, J. Wang, J. Shi, Y. Sun, W. Wang, G. Ning, R. Liu, and J. Hong. 2017. Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice. Journal of Molecular Endocrinology 58 (1):1–14.

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