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Gluten-related disorders: Celiac disease, wheat allergy, and nonceliac gluten sensitivity

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References

  • Abadie, V., V. Discepolo, and B. Jabri. 2012. Intraepithelial lymphocytes in celiac disease immunopathology. Seminars in Immunopathology 34 (4):551–66. doi: 10.1007/s00281-012-0316-x.
  • Alessio, M. G., E. Tonutti, I. Brusca, A. Radice, L. Licini, A. Sonzogni, A. Florena, E. Schiaffino, W. Marus, et al. 2012. Correlation between IgA tissue transglutaminase antibody ratio and histological finding in celiac disease. Journal of Pediatric Gastroenterology and Nutrition 55 (1):44–9. doi: 10.1097/MPG.0b013e3182470249.
  • Allen, K. J., P. J. Turner, R. Pawankar, S. Taylor, S. Sicherer, G. Lack, N. Rosario, M. Ebisawa, G. Wong, E. N. C. Mills, et al. 2014. Precautionary labelling of foods for allergen content: Are we ready for a global framework? World Allergy Organization Journal J 7:10. doi: 10.1186/1939-4551-7-10.
  • Arentz-Hansen, H., B. Fleckenstein, Ø. Molberg, H. Scott, F. Koning, G. Jung, P. Roepstorff, K. E. Lundin, and L. M. Sollid. 2004. The molecular basis for oat intolerance in patients with celiac disease. PLoS Medicine 1 (1):e1. doi: 10.1371/journal.pmed.0010001.
  • Armentia, A., A. Díaz-Perales, J. Castrodeza, A. Dueñas-Laita, A. Palacin, and S. Fernández. 2009. Why can patients with baker’s asthma tolerate wheat flour ingestion? Is wheat pollen allergy relevant? Allergologia et Immunopathologia 37 (4):203–4. doi: 10.1016/j.aller.2009.05.001.
  • Baar, A., S. Pahr, C. Constantin, S. Giavi, A. Manoussaki, N. G. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, and R. Valenta. 2014. Specific IgE reactivity to tri a 36 in children with wheat food allergy. Journal of Allergy and Clinical Immunology 133 (2):585–7. doi: 10.1016/j.jaci.2013.10.044.
  • Baar, A., S. Pahr, C. Constantin, S. Scheiblhofer, J. Thalhamer, S. Giavi, N. G. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, and R. Valenta. 2012. Molecular and immunological characterization of tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen. The Journal of Immunology 189 (6):3018–25. doi: 10.4049/jimmunol.1200438.
  • Barak, S., D. Mudgil, and B. Khatkar. 2013. Relationship of gliadin and glutenin proteins with dough rheology, flour pasting and bread making performance of wheat varieties. LWT - Food Science and Technology 51 (1):211–7. doi: 10.1016/j.lwt.2012.09.011.
  • Barratt, S. M., J. S. Leeds, and D. S. Sanders. 2011. Quality of life in coeliac disease is determined by perceived degree of difficulty adhering to a gluten-free diet, not the level of dietary adherence ultimately achieved. Journal of Gastrointestinal and Liver Diseases 20:241–5.
  • Bergseng, E., S. Dørum, M. Arntzen, M. Nielsen, S. Nygård, S. Buus, G. A. De Souza, and L. M. Sollid. 2015. Different binding motifs of the celiac disease-associated HLA molecules dq2.5, dq2.2, and dq7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires. Immunogenetics 67 (2):73–84. doi: 10.1007/s00251-014-0819-9.
  • Berin, M. C., and H. A. Sampson. 2013. Mucosal immunology of food allergy. Current Biology 23 (9):R389–400. doi: 10.1016/j.cub.2013.02.043.
  • Biesiekierski, J. R. 2017. What is gluten? Journal of Gastroenterology and Hepatology 32:78–81. doi: 10.1111/jgh.13703.
  • Biesiekierski, J. R., S. L. Peters, E. D. Newnham, O. Rosella, J. G. Muir, and P. R. Gibson. 2013. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 145 (2):320–8.
  • Blumchen, K., H. Ulbricht, U. Staden, K. Dobberstein, J. Beschorner, L. C. De Oliveira, W. G. Shreffler, H. A. Sampson, B. Niggemann, U. Wahn, and K. Beyer. 2010. Oral peanut immunotherapy in children with peanut anaphylaxis. Journal of Allergy and Clinical Immunology 126 (1):83–91. doi: 10.1016/j.jaci.2010.04.030.
  • Bouziat, R., R. Hinterleitner, J. J. Brown, J. E. Stencel-Baerenwald, M. Ikizler, T. Mayassi, M. Meisel, S. M. Kim, V. Discepolo, A. J. Pruijssers, et al. 2017. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 356 (6333):44–50. doi: 10.1126/science.aah5298.
  • Brant, A. 2007. Baker’s asthma. Current Opinion in Allergy and Clinical Immunology 7 (2):152–5. doi: 10.1097/ACI.0b013e328042ba77.
  • Brottveit, M., A. C. Beitnes, S. Tollefsen, J. E. Bratlie, F. L. Jahnsen, F. E. Johansen, L. M. Sollid, and K. E. Lundin. 2013. Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. The American Journal of Gastroenterology 108 (5):842–50. doi: 10.1038/ajg.2013.91.
  • Brown, J. J., B. Jabri, and T. S. Dermody. 2018. A viral trigger for celiac disease. PLOS Pathogens 14 (9):e1007181. doi: 10.1371/journal.ppat.1007181.
  • Burks, A. W., S. M. Jones, R. A. Wood, D. M. Fleischer, S. H. Sicherer, R. W. Lindblad, D. Stablein, A. K. Henning, B. P. Vickery, A. H. Liu, et al. 2012. Oral immunotherapy for treatment of egg allergy in children. The New England Journal of Medicine 367 (3):233–43. doi: 10.1056/NEJMoa1200435.
  • Cabrera-Chávez, F., G. V. Dezar, A. P. Islas-Zamorano, J. G. Espinoza-Alderete, M. J. Vergara-Jiménez, D. Magaña-Ordorica, and N. Ontiveros. 2017. Prevalence of self-reported gluten sensitivity and adherence to a gluten-free diet in argentinian adult population. Nutrients 9 (1):81. doi: 10.3390/nu9010081.
  • Cabrera-Chávez, F., D. M. Granda-Restrepo, J. G. Arámburo-Gálvez, A. Franco-Aguilar, D. Magaña-Ordorica, M. E. J. Vergara-Jiménez, and N. Ontiveros. 2016. Self-reported prevalence of gluten-related disorders and adherence to gluten-free diet in Colombian adult population. Gastroenterology Research and Practice 2016:1. doi: 10.1155/2016/4704309.
  • Camarca, A., R. P. Anderson, G. Mamone, O. Fierro, A. Facchiano, S. Costantini, D. Zanzi, J. Sidney, S. Auricchio, A. Sette, et al. 2009. Intestinal t cell responses to gluten peptides are largely heterogeneous: Implications for a peptide-based therapy in celiac disease. The Journal of Immunology 182 (7):4158–66. doi: 10.4049/jimmunol.0803181.
  • Camarca, A., A. Del Mastro, and C. Gianfrani. 2012. Repertoire of gluten peptides active in celiac disease patients: Perspectives for translational therapeutic applications. Endocrine, Metabolic & Immune Disorders - Drug Targets 12:207–19. doi: 10.2174/187153012800493549.
  • Caputo, I., M. Lepretti, A. Secondo, S. Martucciello, G. Paolella, D. Sblattero, M. V. Barone, and C. Esposito. 2013. Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic ca2+ homeostasis. Amino Acids 44 (1):251–60. doi: 10.1007/s00726-011-1120-y.
  • Carroccio, A., G. Giannone, P. Mansueto, M. Soresi, F. La Blasca, F. Fayer, R. Iacobucci, R. Porcasi, T. Catalano, G. Geraci, et al. 2019. Duodenal and rectal mucosa inflammation in patients with non-celiac wheat sensitivity. Clinical Gastroenterology and Hepatology 17 (4):682–90. doi: 10.1016/j.cgh.2018.08.043.
  • Carroccio, A., P. Mansueto, G. Iacono, M. Soresi, A. Dʼalcamo, F. Cavataio, I. Brusca, A. M. Florena, G. Ambrosiano, A. Seidita, et al. 2012. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: Exploring a new clinical entity. The American Journal of Gastroenterology 107 (12):1898–906., doi: 10.1038/ajg.2012.236.
  • Castillo, N. E., T. G. Theethira, and D. A. Leffler. 2015. The present and the future in the diagnosis and management of celiac disease. Gastroenterology Report 3 (1):3–11. doi: 10.1093/gastro/gou065.
  • Catassi, C., L. Elli, B. Bonaz, G. Bouma, A. Carroccio, G. Castillejo, C. Cellier, F. Cristofori, L. De Magistris, J. Dolinsek, et al. 2015. Diagnosis of non-celiac gluten sensitivity (NCGS): The Salerno experts’ criteria. Nutrients 7 (6):4966–77. doi: 10.3390/nu7064966.
  • Christensen, M. J., E. Eller, C. G. Mortz, K. Brockow, and C. Bindslev-Jensen. 2019. Wheat-dependent cofactor-augmented anaphylaxis: A prospective study of exercise, aspirin, and alcohol efficacy as cofactors. The Journal of Allergy and Clinical Immunology: In Practice 7 (1):114–21. doi: 10.1016/j.jaip.2018.06.018.
  • Cianferoni, A. 2016. Wheat allergy: Diagnosis and management. Journal of Asthma and Allergy 9:13–25. doi: 10.2147/JAA.S81550.
  • Collin, P., T. T. Salmi, K. Hervonen, K. Kaukinen, and T. Reunala. 2017. Dermatitis herpetiformis: A cutaneous manifestation of coeliac disease. Annals of Medicine 49 (1):23–31. doi: 10.1080/07853890.2016.1222450.
  • Constantin, C., S. Quirce, M. Grote, A. Touraev, I. Swoboda, A. Stoecklinger, A. Mari, J. Thalhamer, E. Heberle-Bors, and R. Valenta. 2008. Molecular and immunological characterization of a wheat serine proteinase inhibitor as a novel allergen in baker’s asthma. The Journal of Immunology 180 (11):7451–60. doi: 10.4049/jimmunol.180.11.7451.
  • Cook, L., C. M. L. Munier, N. Seddiki, D. Van Bockel, N. Ontiveros, M. Y. Hardy, J. K. Gillies, M. K. Levings, H. H. Reid, J. Petersen, et al. 2017. Circulating gluten-specific FOXP3. Journal of Allergy and Clinical Immunology 140 (6):1592–603. doi: 10.1016/j.jaci.2017.02.015.
  • Craig, M. E., N. Prinz, C. T. Boyle, F. M. Campbell, T. W. Jones, S. E. Hofer, J. H. Simmons, N. Holman, E. Tham, E. Fröhlich-Reiterer, et al. 2017. Prevalence of celiac disease in 52,721 youth with type 1 diabetes: International comparison across three continents. Diabetes Care 40 (8):1034–40. doi: 10.2337/dc16-2508.
  • Day, L., M. Augustin, I. Batey, and C. Wrigley. 2006. Wheat-gluten uses and industry needs. Trends in Food Science & Technology 17:82–90. doi: 10.1016/j.tifs.2005.10.003.
  • De Brier, N., S. V. Gomand, I. Celus, C. M. Courtin, K. Brijs, and J. A. Delcour. 2015. Extractability and chromatographic characterization of wheat (Triticum aestivum L.) bran protein. Journal of Food Science 80 (5):C967–74. doi: 10.1111/1750-3841.12856.
  • Di Niro, R., L. Mesin, N. Y. Zheng, J. Stamnaes, M. Morrissey, J. H. Lee, M. Huang, R. Iversen, M. F. Du Pré, S. W. Qiao, et al. 2012. High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nature Medicine 18 (3):441–5. doi: 10.1038/nm.2656.
  • Di Sabatino, A., K. M. Pickard, J. N. Gordon, V. Salvati, G. Mazzarella, R. M. Beattie, A. Vossenkaemper, L. Rovedatti, N. A. Leakey, N. M. Croft, et al. 2007. Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology 133 (4):1175–87. doi: 10.1053/j.gastro.2007.08.018.
  • Di Sabatino, A., A. Vanoli, P. Giuffrida, O. Luinetti, E. Solcia, and G. Corazza. 2012. The function of tissue transglutaminase in celiac disease. Autoimmunity Reviews 11 (10):746–53. doi: 10.1016/j.autrev.2012.01.007.
  • Dieterich, W., D. Schuppan, M. Schink, R. Schwappacher, S. Wirtz, A. Agaimy, M. F. Neurath, and Y. Zopf. 2019. Influence of low FODMAP and gluten-free diets on disease activity and intestinal microbiota in patients with non-celiac gluten sensitivity. Clinical Nutrition 38 (2):697–707. doi: 10.1016/j.clnu.2018.03.017.
  • El-Salhy, M., J. G. Hatlebakk, O. H. Gilja, and T. Hausken. 2015. The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome. Nutrition Journal 14 (1):92. doi: 10.1186/s12937-015-0080-6.
  • Escudero-Hernández, C., A. S. Peña, and D. Bernardo. 2016. Immunogenetic pathogenesis of celiac disease and non-celiac gluten sensitivity. Current Gastroenterology Reports 18 (7):36. doi: 10.1007/s11894-016-0512-2.
  • Esteller, M., R. Pitombo, and S. Lannes. 2005. Effect of freeze-dried gluten addition on texture of hamburger buns. Journal of Cereal Science 41 (1):19–21. doi: 10.1016/j.jcs.2004.08.013.
  • Ettersperger, J., N. Montcuquet, G. Malamut, N. Guegan, S. Lopez-Lastra, S. Gayraud, C. Reimann, E. Vidal, N. Cagnard, P. Villarese, et al. 2016. Interleukin-15-dependent t-cell-like innate intraepithelial lymphocytes develop in the intestine and transform into lymphomas in celiac disease. Immunity 45 (3):610–25. doi: 10.1016/j.immuni.2016.07.018.
  • Fallang, L. E., E. Bergseng, K. Hotta, A. Berg-Larsen, C. Y. Kim, and L. M. Sollid. 2009. Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation. Nature Immunology 10 (10):1096–101. doi: 10.1038/ni.1780.
  • Fasano, A., A. Sapone, V. Zevallos, and D. Schuppan. 2015. Nonceliac gluten sensitivity. Gastroenterology 148 (6):1195–204. doi: 10.1053/j.gastro.2014.12.049.
  • Figueroa-Salcido, O. G., N. Ontiveros, and F. Cabrera-Chávez. 2019. Gluten vehicle and placebo for non-celiac gluten sensitivity assessment. Medicina (Kaunas) 55 (5):117.
  • Francisco, C. C., S. O. Gerardo, and O. Noé. 2018. The indistinguishable gluten vehicle and placebo in the diagnosis of NCGS. American Journal of Gastroenterology 113 (10):1559–60. doi: 10.1038/s41395-018-0127-3.
  • Goel, G., T. King, A. J. Daveson, J. M. Andrews, J. Krishnarajah, R. Krause, G. J. E. Brown, R. Fogel, C. F. Barish, R. Epstein, et al. 2017. Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: Two randomised, double-blind, placebo-controlled phase 1 studies. The Lancet Gastroenterology & Hepatology 2:479–93. doi: 10.1016/S2468-1253(17)30110-3.
  • Guandalini, S., and A. Assiri. 2014. Celiac disease: A review. JAMA Pediatrics 168 (3):272–8. doi: 10.1001/jamapediatrics.2013.3858.
  • Gujral, N., H. J. Freeman, and A. B. Thomson. 2012. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World Journal of Gastroenterology 18 (42):6036–59. doi: 10.3748/wjg.v18.i42.6036.
  • Guo, C. C., W. H. Huang, N. Zhang, F. Dong, L. P. Jing, Y. Liu, X. G. Ye, D. Xiao, M. L. Ou, B. H. Zhang, et al. 2015. Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: A meta-analysis. Genetics and Molecular Research 14 (4):13221–35. doi: 10.4238/2015.October.26.19.
  • Gutierrez-Achury, J., A. Zhernakova, S. L. Pulit, G. Trynka, K. A. Hunt, J. Romanos, S. Raychaudhuri, D. A. Van Heel, C. Wijmenga, and P. I. De Bakker. 2015. Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease. Nature Genetics 47 (6):577–8. doi: 10.1038/ng.3268.
  • Hadjivassiliou, M., I. D. Croall, P. Zis, P. G. Sarrigiannis, D. S. Sanders, P. Aeschlimann, R. A. Grünewald, P. A. Armitage, D. Connolly, D. Aeschlimann, and N. Hoggard. 2019. Neurologic deficits in patients with newly diagnosed celiac disease are frequent and linked with autoimmunity to transglutaminase 6. Clinical Gastroenterology and Hepatology. doi: 10.1016/j.cgh.2019.03.014.
  • Han, A., E. W. Newell, J. Glanville, N. Fernandez-Becker, C. Khosla, Y. H. Chien, and M. M. Davis. 2013. Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proceedings of the National Academy of Sciences of the United States of America 110 (32):13073–8. doi: 10.1073/pnas.1311861110.
  • Hausch, F., L. Shan, N. A. Santiago, G. M. Gray, and C. Khosla. 2002. Intestinal digestive resistance of immunodominant gliadin peptides. American Journal of Physiology-Gastrointestinal and Liver Physiology 283 (4):G996–1003. doi: 10.1152/ajpgi.00136.2002.
  • Häuser, W., K. H. Janke, B. Klump, M. Gregor, and A. Hinz. 2010. Anxiety and depression in adult patients with celiac disease on a gluten-free diet. World Journal of Gastroenterology 16 (22):2780–7. doi: 10.3748/wjg.v16.i22.2780.
  • Herrera, M. G., M. Pizzuto, C. Lonez, K. Rott, A. Hütten, N. Sewald, J. M. Ruysschaert, and V. I. Dodero. 2018. Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages. Nanomedicine 14 (4):1417–27. doi: 10.1016/j.nano.2018.04.014.
  • Hofer, G., S. Wieser, M. K. Bogdos, P. Gattinger, R. Nakamura, M. Ebisawa, M. Mäkelä, N. Papadopoulos, R. Valenta, and W. Keller. 2018. Three-dimensional structure of the wheat β-amylase Tri a 17, a clinically relevant food allergen. Allergy doi: 10.1111/all.13696.
  • Hollon, J., E. L. Puppa, B. Greenwald, E. Goldberg, A. Guerrerio, and A. Fasano. 2015. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients 7 (3):1565–76. doi: 10.3390/nu7031565.
  • Hopper, A. D., M. Hadjivassiliou, D. P. Hurlstone, A. J. Lobo, M. E. Mcalindon, W. Egner, G. Wild, and D. S. Sanders. 2008. What is the role of serologic testing in celiac disease? A prospective, biopsy-confirmed study with economic analysis. Clinical Gastroenterology and Hepatology 6 (3):314–20. doi: 10.1016/j.cgh.2007.12.008.
  • Husby, S., S. Koletzko, I. R. Korponay-Szabó, M. L. Mearin, A. Phillips, R. Shamir, R. Troncone, K. Giersiepen, D. Branski, C. Catassi, et al. 2012. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. Journal of Pediatric Gastroenterology and Nutrition 54 (1):136–60. doi: 10.1097/MPG.0b013e31821a23d0.
  • Infantino, M., M. Manfredi, F. Meacci, V. Grossi, M. Severino, M. Benucci, E. Bellio, V. Bellio, A. Nucci, F. Zolfanelli, et al. 2015. Diagnostic accuracy of anti-gliadin antibodies in non celiac gluten sensitivity (NCGS) patients: A dual statistical approach. Clinica Chimica Acta 451:135–41. doi: 10.1016/j.cca.2015.09.017.
  • Infantino, M., F. Meacci, V. Grossi, D. Macchia, and M. Manfredi. 2017. Anti-gliadin antibodies in non-celiac gluten sensitivity. Minerva Gastroenterologica e Dietologica 63:1–4.
  • Inomata, N. 2009. Wheat allergy. Current Opinion in Allergy and Clinical Immunology 9 (3):238–43. doi: 10.1097/ACI.0b013e32832aa5bc.
  • Jackson, J. R., W. W. Eaton, N. G. Cascella, A. Fasano, and D. L. Kelly. 2012. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatric Quarterly 83 (1):91–102. doi: 10.1007/s11126-011-9186-y.
  • Jericho, H., N. Sansotta, and S. Guandalini. 2017. Extraintestinal manifestations of celiac disease: Effectiveness of the gluten-free diet. Journal of Pediatric Gastroenterology and Nutrition 65 (1):75–9. doi: 10.1097/MPG.0000000000001420.
  • Jones, S. M., C. F. Magnolfi, S. K. Cooke, and H. A. Sampson. 1995. Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. Journal of Allergy and Clinical Immunology 96 (3):341–51. doi: 10.1016/S0091-6749(95)70053-6.
  • Junker, Y., S. Zeissig, S. J. Kim, D. Barisani, H. Wieser, D. A. Leffler, V. Zevallos, T. A. Libermann, S. Dillon, T. L. Freitag, et al. 2012. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. The Journal of Experimental Medicine 209 (13):2395–408. doi: 10.1084/jem.20102660.
  • Keet, C. A., E. C. Matsui, G. Dhillon, P. Lenehan, M. Paterakis, and R. A. Wood. 2009. The natural history of wheat allergy. Annals of Allergy, Asthma & Immunology 102 (5):410. doi: 10.1016/S1081-1206(10)60513-3.
  • Kelly, C., J. Bai, E. Liu, and D. Leffler. 2015. Celiac disease: Clinical spectrum and management. Gastroenterology 148 (6):1175–86. doi: 10.1053/j.gastro.2015.01.044.
  • Khayatzadeh, A., M. Gharaghozlou, M. Ebisawa, R. Shokouhi Shoormasti, and M. Movahedi. 2016. A safe and effective method for wheat oral immunotherapy. Iranian Journal of Allergy, Asthma and Immunology 15:525–35.
  • Kim, S. M., T. Mayassi, and B. Jabri. 2015. Innate immunity: Actuating the gears of celiac disease pathogenesis. Best Practice & Research Clinical Gastroenterology 29:425–35. doi: 10.1016/j.bpg.2015.05.001.
  • Kooy-Winkelaar, Y. M., D. Bouwer, G. M. Janssen, A. Thompson, M. H. Brugman, F. Schmitz, A. H. De Ru, T. Van Gils, G. Bouma, J. J. Van Rood, et al. 2017. CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes. Proceedings of the National Academy of Sciences 114 (6):E980–E89. doi: 10.1073/pnas.1620036114.
  • Kurppa, K., A. Laitinen, and D. Agardh. 2018. Coeliac disease in children with type 1 diabetes. The Lancet. Child & Adolescent Health 2 (2):133–43. doi: 10.1016/S2352-4642(17)30172-4.
  • Lähdeaho, M. L., K. Kaukinen, K. Laurila, P. Vuotikka, O. P. Koivurova, T. Kärjä-Lahdensuu, A. Marcantonio, D. C. Adelman, and M. Mäki. 2014. Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease. Gastroenterology 146 (7):1649–58. doi: 10.1053/j.gastro.2014.02.031.
  • Lammers, K. M., M. Chieppa, L. Liu, S. Liu, T. Omatsu, M. Janka-Junttila, V. Casolaro, H. C. Reinecker, C. A. Parent, and A. Fasano. 2015. Gliadin induces neutrophil migration via engagement of the formyl peptide receptor, FPR1. PLoS One 10 (9):e0138338. doi: 10.1371/journal.pone.0138338.
  • Lammers, K. M., R. Lu, J. Brownley, B. Lu, C. Gerard, K. Thomas, P. Rallabhandi, T. Shea-Donohue, A. Tamiz, S. Alkan, et al. 2008. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor cxcr3. Gastroenterology 135 (1):194–204. doi: 10.1053/j.gastro.2008.03.023.
  • Le, T. A., M. Al Kindi, J. A. Tan, A. Smith, R. J. Heddle, F. E. Kette, P. Hissaria, and W. B. Smith. 2016. The clinical spectrum of omega-5-gliadin allergy. Internal Medicine Journal 46 (6):710–6. doi: 10.1111/imj.13091.
  • Lebwohl, B., D. S. Sanders, and P. H. R. Green. 2018. Coeliac disease. Lancet (London, England) 391 (10115):70–81. doi: 10.1016/S0140-6736(17)31796-8.
  • Leffler, D. A., C. P. Kelly, P. H. Green, R. N. Fedorak, A. Dimarino, W. Perrow, H. Rasmussen, C. Wang, P. Bercik, N. M. Bachir, and J. A. Murray. 2015. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: A randomized controlled trial. Gastroenterology 148 (7):1311–9. doi: 10.1053/j.gastro.2015.02.008.
  • Leonard, M. M., A. Sapone, C. Catassi, and A. Fasano. 2017. Celiac disease and nonceliac gluten sensitivity: A review. JAMA 318 (7):647–56. doi: 10.1001/jama.2017.9730.
  • Lytton, S. D., E. Antiga, S. Pfeiffer, T. Matthias, A. Szaflarska-Poplawska, V. K. Ulaganathan, W. Placek, P. Fabbri, R. Hall, and M. Caproni. 2013. Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease–dermatitis herpetiformis. Clinica Chimica Acta 415:346–9. doi: 10.1016/j.cca.2012.10.051.
  • Mahmud, F. H., J. A. Murray, Y. C. Kudva, A. R. Zinsmeister, R. A. Dierkhising, B. D. Lahr, P. J. Dyck, R. A. Kyle, M. El-Youssef, L. J. Burgart, et al. 2005. Celiac disease in type 1 diabetes mellitus in a North American community: Prevalence, serologic screening, and clinical features. Mayo Clinic Proceedings 80 (11):1429–34. doi: 10.4065/80.11.1429.
  • Meresse, B., N. Korneychuk, G. Malamut, and N. Cerf-Bensussan. 2015. Interleukin-15, a master piece in the immunological jigsaw of celiac disease. Digestive Diseases 33 (2):122–30. doi: 10.1159/000369521.
  • Meresse, B., G. Malamut, and N. Cerf-Bensussan. 2012. Celiac disease: An immunological jigsaw. Immunity 36 (6):907–19. doi: 10.1016/j.immuni.2012.06.006.
  • Molberg, Ø., A. K. Uhlen, T. Jensen, N. S. Flaete, B. Fleckenstein, H. Arentz-Hansen, M. Raki, K. E. A. Lundin, and L. M. Sollid. 2005. Mapping of gluten T-cell epitopes in the bread wheat ancestors: Implications for celiac disease. Gastroenterology 128 (2):393–401. doi: 10.1053/j.gastro.2004.11.003.
  • Morita, E., H. Matsuo, Y. Chinuki, H. Takahashi, J. Dahlström, and A. Tanaka. 2009. Food-dependent exercise-induced anaphylaxis - Importance of omega-5 gliadin and HMW-glutenin as causative antigens for wheat-dependent exercise-induced anaphylaxis. Allergology International 58:493–8.
  • Muir, J. G., J. E. Varney, M. Ajamian, and P. R. Gibson. 2019. Gluten-free and low-FODMAP sourdoughs for patients with coeliac disease and irritable bowel syndrome: A clinical perspective. International Journal of Food Microbiology 290:237–46. doi: 10.1016/j.ijfoodmicro.2018.10.016.
  • Murray, J. A., C. P. Kelly, P. H. R. Green, A. Marcantonio, T. T. Wu, M. Mäki, and D. C. Adelman; CeliAction Study Group of Investigators. 2017. No difference between latiglutenase and placebo in reducing villous atrophy or improving symptoms in patients with symptomatic celiac disease. Gastroenterology 152 (4):787–98. doi: 10.1053/j.gastro.2016.11.004.
  • Mustalahti, K., C. Catassi, A. Reunanen, E. Fabiani, M. Heier, S. Mcmillan, L. Murray, M. H. Metzger, M. Gasparin, E. Bravi, et al. 2010. The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project. Annals of Medicine 42 (8):587–95. doi: 10.3109/07853890.2010.505931.
  • Niland, B., and B. D. Cash. 2018. Health benefits and adverse effects of a gluten-free diet in non-celiac disease patients. Gastroenterology and Hepatology 14:82–91.
  • Nilsson, N., C. Nilsson, H. Ekoff, S. Wieser-Pahr, M. P. Borres, R. Valenta, G. Hedlin, and S. Sjölander. 2018. Grass-allergic children frequently show asymptomatic low-level IgE co-sensitization and cross-reactivity to wheat. International Archives of Allergy and Immunology 177 (2):135–44. doi: 10.1159/000489610.
  • Nilsson, N., S. Sjölander, A. Baar, M. Berthold, S. Pahr, S. Vrtala, R. Valenta, E. Morita, G. Hedlin, M. P. Borres, and C. Nilsson. 2015. Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components. Pediatric Allergy and Immunology 26 (2):119–25. doi: 10.1111/pai.12334.
  • Nordqvist, P., D. Thedjil, S. Khosravi, M. Lawther, E. Malmström, and F. Khabbaz. 2012. Wheat gluten fractions as wood adhesives—Glutenins versus gliadins. Journal of Applied Polymer Science 123 (3):1530–8. doi: 10.1002/app.34312.
  • Ontiveros, N., M. Y. Hardy, and F. Cabrera-Chávez. 2015a. Assessing of celiac disease and nonceliac gluten sensitivity. Gastroenterology Research and Practice 2015:1. doi: 10.1155/2015/723954.
  • Ontiveros, N., J. A. López-Gallardo, M. J. Vergara-Jiménez, and F. Cabrera-Chávez. 2015b. Self-reported prevalence of symptomatic adverse reactions to gluten and adherence to gluten-free diet in an adult Mexican population. Nutrients 7 (7):6000–15. doi: 10.3390/nu7075267.
  • Ontiveros, N., C. I. Rodríguez-Bellegarrigue, G. Galicia-Rodríguez, M. J. Vergara-Jiménez, E. M. Zepeda-Gómez, J. G. Arámburo-Galvez, M. H. Gracia-Valenzuela, and F. Cabrera-Chávez. 2018. Prevalence of self-reported gluten-related disorders and adherence to a gluten-free diet in Salvadoran adult population. International Journal of Environmental Research and Public Health 15 (4):786. doi: 10.3390/ijerph15040786.
  • Ontiveros, N., J. A. Tye-Din, M. Y. Hardy, and R. P. Anderson. 2014. Ex-vivo whole blood secretion of interferon (IFN)-γ and IFN-γ-inducible protein-10 measured by enzyme-linked immunosorbent assay are as sensitive as IFL-γ enzyme-linked immunospot for the detection of gluten-reactive T cells in human leucocyte antigen (HLA)-DQ2.5(±)-associated coeliac disease. Clinical & Experimental Immunology 175:305–15.
  • Pacharn, P., and P. Vichyanond. 2017. Immunotherapy for IgE-mediated wheat allergy. Human Vaccines & Immunotherapeutics 13:2462–6. doi: 10.1080/21645515.2017.1356499.
  • Pahr, S., C. Constantin, A. Mari, S. Scheiblhofer, J. Thalhamer, C. Ebner, S. Vrtala, I. Mittermann, and R. Valenta. 2012. Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy. Clinical & Experimental Allergy 42:597–609. doi: 10.1111/j.1365-2222.2012.03961.x.
  • Pahr, S., C. Constantin, N. G. Papadopoulos, S. Giavi, M. Mäkelä, A. Pelkonen, C. Ebner, A. Mari, S. Scheiblhofer, J. Thalhamer, et al. 2013. Α-purothionin, a new wheat allergen associated with severe allergy. Journal of Allergy and Clinical Immunology 132 (4):1000–3. doi: 10.1016/j.jaci.2013.05.016.
  • Palacin, A., J. Bartra, R. Muñoz, A. Diaz-Perales, A. Valero, and G. Salcedo. 2010. Anaphylaxis to wheat flour-derived foodstuffs and the lipid transfer protein syndrome: A potential role of wheat lipid transfer protein tri a 14. International Archives of Allergy and Immunology 152 (2):178–83. doi: 10.1159/000265539.
  • Palacin, A., S. Quirce, A. Armentia, M. Fernández-Nieto, L. Pacios, T. Asensio, J. Sastre, A. Diaz-Perales, and G. Salcedo. 2007. Wheat lipid transfer protein is a major allergen associated with baker’s asthma. Journal of Allergy and Clinical Immunology 120 (5):1132–8. doi: 10.1016/j.jaci.2007.07.008.
  • Palacin, A., J. Varela, S. Quirce, V. Del Pozo, L. Tordesillas, P. Barranco, M. Fernandez-Nieto, J. Sastre, A. Diaz-Perales, and G. Salcedo. 2009. Recombinant lipid transfer protein tri a 14: A novel heat and proteolytic resistant tool for the diagnosis of baker’s asthma. Clinical & Experimental Allergy 39:1267–76. doi: 10.1111/j.1365-2222.2009.03280.x.
  • Pastorello, E. A., L. Farioli, A. Conti, V. Pravettoni, S. Bonomi, S. Iametti, D. Fortunato, J. Scibilia, C. Bindslev-Jensen, B. Ballmer-Weber, et al. 2007. Wheat IgE-mediated food allergy in European patients: Alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. International Archives of Allergy and Immunology 144 (1):10–22. doi: 10.1159/000102609.
  • Pietzak, M. 2012. Celiac disease, wheat allergy, and gluten sensitivity: When gluten free is not a fad. Journal of Parenteral and Enteral Nutrition 36 (1_suppl):68S–75S. doi: 10.1177/0148607111426276.
  • Pinto-Sánchez, M. I., N. Causada-Calo, P. Bercik, A. C. Ford, J. A. Murray, D. Armstrong, C. Semrad, S. S. Kupfer, A. Alaedini, P. Moayyedi, et al. 2017. Safety of adding oats to a gluten-free diet for patients with celiac disease: Systematic review and Meta-analysis of clinical and observational studies. Gastroenterology 153 (2):395–409. doi: 10.1053/j.gastro.2017.04.009.
  • Pourpak, Z., M. Mesdaghi, M. Mansouri, A. Kazemnejad, S. B. Toosi, and A. Farhoudi. 2005. Which cereal is a suitable substitute for wheat in children with wheat allergy? Pediatric Allergy and Immunology 16 (3):262–6. doi: 10.1111/j.1399-3038.2005.00263.x.
  • Quirce, S., T. Boyano-Martínez, and A. Díaz-Perales. 2016. Clinical presentation, allergens, and management of wheat allergy. Expert Review of Clinical Immunology 12 (5):563–72. doi: 10.1586/1744666X.2016.1145548.
  • Quirce, S., and A. Diaz-Perales. 2013. Diagnosis and management of grain-induced asthma. Allergy, Asthma & Immunology Research 5:348–56. doi: 10.4168/aair.2013.5.6.348.
  • Real, A., I. Comino, L. De Lorenzo, F. Merchán, J. Gil-Humanes, M. J. Giménez, M. López-Casado, M. I. Torres, Á. Cebolla, C. Sousa, et al. 2012. Molecular and immunological characterization of gluten proteins isolated from oat cultivars that differ in toxicity for celiac disease. PLoS One 7 (12):e48365. doi: 10.1371/journal.pone.0048365.
  • Reese, I., C. Schäfer, J. Kleine-Tebbe, B. Ahrens, O. Bachmann, B. Ballmer-Weber, K. Beyer, S. C. Bischoff, K. Blümchen, S. Dölle, et al. 2018. Non-celiac gluten/wheat sensitivity (NCGS) – A currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI). Allergo Journal International 27:147–51. doi: 10.1007/s40629-018-0070-2.
  • Reilly, N. R. 2016. The gluten-free diet: Recognizing fact, fiction, and fad. The Journal of Pediatrics 175:206–10. doi: 10.1016/j.jpeds.2016.04.014.
  • Repo, M., K. Lindfors, M. Mäki, H. Huhtala, K. Laurila, M. L. Lähdeaho, P. Saavalainen, K. Kaukinen, and K. Kurppa. 2017. Anemia and iron deficiency in children with potential celiac disease. Journal of Pediatric Gastroenterology and Nutrition 64 (1):56–62. doi: 10.1097/MPG.0000000000001234.
  • Ribeiro, M., M. Rodriguez-Quijano, F. Nunes, J. Carrillo, G. Branlard, and G. Igrejas. 2016. New insights into wheat toxicity: Breeding did not seem to contribute to a prevalence of potential celiac disease’s immunostimulatory epitopes. Food Chemistry 213:8–18. doi: 10.1016/j.foodchem.2016.06.043.
  • Risnes, L. F., A. Christophersen, S. Dahal-Koirala, R. S. Neumann, G. K. Sandve, V. K. Sarna, K. E. Lundin, S. W. Qiao, and L. M. Sollid. 2018. Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease. The Journal of Clinical Investigation 128 (6):2642–50. doi: 10.1172/JCI98819.
  • Rodríguez Del Río, P., A. Díaz-Perales, S. Sanchez-García, C. Escudero, P. Do Santos, M. Catarino, and M. D. Ibañez. 2014. Oral immunotherapy in children with IgE-mediated wheat allergy: Outcome and molecular changes. Journal of Investigational Allergology and Clinical Immunology 24:240–8.
  • Romanos, J., A. Rosén, V. Kumar, G. Trynka, L. Franke, A. Szperl, J. Gutierrez-Achury, C. C. Van Diemen, R. Kanninga, S. A. Jankipersadsing, et al. 2014. Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. Gut 63 (3):415–22. doi: 10.1136/gutjnl-2012-304110.
  • Roncoroni, L., K. A. Bascuñán, M. Vecchi, L. Doneda, M. T. Bardella, V. Lombardo, A. Scricciolo, F. Branchi, and L. Elli. 2019. Exposure to different amounts of dietary gluten in patients with non-celiac gluten sensitivity (NCGS): An exploratory study. Nutrients 11 (1):136. doi: 10.3390/nu11010136.
  • Rotondi Aufiero, V., A. Fasano, and G. Mazzarella. 2018. Non-celiac gluten sensitivity: How its gut immune activation and potential dietary management differ from celiac disease. Molecular Nutrition & Food Research 62:e1700854. doi: 10.1002/mnfr.201700854.
  • Rubio-Tapia, A., I. D. Hill, C. P. Kelly, A. H. Calderwood, and J. A. Murray; American College of Gastroenterology. 2013. ACG clinical guidelines: Diagnosis and management of celiac disease. The American Journal of Gastroenterology 108 (5):656–76. doi: 10.1038/ajg.2013.79.
  • Rubio-Tapia, A., M. W. Rahim, J. A. See, B. D. Lahr, T. T. Wu, and J. A. Murray. 2010. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. The American Journal of Gastroenterology 105 (6):1412–20. doi: 10.1038/ajg.2010.10.
  • Salcedo, G., S. Quirce, and A. Diaz-Perales. 2011. Wheat allergens associated with baker’s asthma. Journal of Investigational Allergology and Clinical Immunology 21:81–92.
  • Sánchez-León, S., J. Gil-Humanes, C. V. Ozuna, M. J. Giménez, C. Sousa, D. F. Voytas, and F. Barro. 2018. Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9. Plant Biotechnology Journal 16 (4):902–10. doi: 10.1111/pbi.12837.
  • Sapone, A., J. C. Bai, C. Ciacci, J. Dolinsek, P. H. Green, M. Hadjivassiliou, K. Kaukinen, K. Rostami, D. S. Sanders, M. Schumann, et al. 2012. Spectrum of gluten-related disorders: Consensus on new nomenclature and classification. BMC Medicine 10 (1):13. doi: 10.1186/1741-7015-10-13.
  • Sapone, A., K. M. Lammers, V. Casolaro, M. Cammarota, M. T. Giuliano, M. De Rosa, R. Stefanile, G. Mazzarella, C. Tolone, M. I. Russo, et al. 2011. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: Celiac disease and gluten sensitivity. BMC Medicine 9 (1):23. doi: 10.1186/1741-7015-9-23.
  • Sato, S., T. Utsunomiya, T. Imai, N. Yanagida, T. Asaumi, K. Ogura, Y. Koike, N. Hayashi, Y. Okada, A. Shukuya, and M. Ebisawa. 2015. Wheat oral immunotherapy for wheat-induced anaphylaxis. Journal of Allergy and Clinical Immunology 136 (4):1131–3. doi: 10.1016/j.jaci.2015.07.019.
  • Schalk, K., C. Lang, H. Wieser, P. Koehler, and K. A. Scherf. 2017a. Quantitation of the immunodominant 33-mer peptide from α-gliadin in wheat flours by liquid chromatography tandem mass spectrometry. Scientific Reports 7 (1):45092. doi: 10.1038/srep45092.
  • Schalk, K., B. Lexhaller, P. Koehler, and K. A. Scherf. 2017b. Isolation and characterization of gluten protein types from wheat, rye, barley and oats for use as reference materials. PLoS One 12 (2):e0172819. doi: 10.1371/journal.pone.0172819.
  • Scherf, K. A., K. Brockow, T. Biedermann, P. Koehler, and H. Wieser. 2016. Wheat-dependent exercise-induced anaphylaxis. Clinical & Experimental Allergy 46:10–20. doi: 10.1111/cea.12640.
  • Sharma, G. M., M. Pereira, and K. M. Williams. 2015. Gluten detection in foods available in the United States – A market survey. Food Chemistry 169:120–6. doi: 10.1016/j.foodchem.2014.07.134.
  • Sicherer, S. H., and H. A. Sampson. 2018. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. Journal of Allergy and Clinical Immunology 141 (1):41–58. doi: 10.1016/j.jaci.2017.11.003.
  • Silvester, J. A., D. Weiten, L. A. Graff, J. R. Walker, and D. R. Duerksen. 2016. Living gluten-free: Adherence, knowledge, lifestyle adaptations and feelings towards a gluten-free diet. Journal of Human Nutrition and Dietetics 29 (3):374–82. doi: 10.1111/jhn.12316.
  • Skripak, J. M., S. D. Nash, H. Rowley, N. H. Brereton, S. Oh, R. G. Hamilton, E. C. Matsui, A. W. Burks, and R. A. Wood. 2008. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow’s milk allergy. Journal of Allergy and Clinical Immunology 122 (6):1154–60. doi: 10.1016/j.jaci.2008.09.030.
  • Sollid, L. M., O. Molberg, S. Mcadam, and K. E. Lundin. 1997. Autoantibodies in coeliac disease: Tissue transglutaminase – Guilt by association? Gut 41 (6):851–2. doi: 10.1136/gut.41.6.851.
  • Sollid, L. M., S. W. Qiao, R. P. Anderson, C. Gianfrani, and F. Koning. 2012. Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules. Immunogenetics 64 (6):455–560. doi: 10.1007/s00251-012-0599-z.
  • Talley, N. J., and M. M. Walker. 2017. Celiac disease and nonceliac gluten or wheat sensitivity: The risks and benefits of diagnosis. JAMA Internal Medicine 177 (5):615–6. doi: 10.1001/jamainternmed.2017.0695.
  • Tollefsen, S., H. Arentz-Hansen, B. Fleckenstein, O. Molberg, M. Ráki, W. W. Kwok, G. Jung, K. E. Lundin, and L. M. Sollid. 2006. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. The Journal of Clinical Investigation 116 (8):2226–36. doi: 10.1172/JCI27620.
  • Tordesillas, L., M. C. Berin, and H. A. Sampson. 2017. Immunology of food allergy. Immunity 47 (1):32–50. doi: 10.1016/j.immuni.2017.07.004.
  • Tye-Din, J. A., J. A. Stewart, J. A. Dromey, T. Beissbarth, D. A. Van Heel, A. Tatham, K. Henderson, S. I. Mannering, C. Gianfrani, D. P. Jewell, et al. 2010. Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Science Translational Medicine 2 (41):41ra51. doi: 10.1126/scitranslmed.3001012.
  • Van Den Broeck, H. C., H. C. De Jong, E. M. Salentijn, L. Dekking, D. Bosch, R. J. Hamer, L. J. Gilissen, I. M. Van Der Meer, and M. J. Smulders. 2010. Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: Wheat breeding may have contributed to increased prevalence of celiac disease. Theoretical and Applied Genetics 121 (8):1527–39. doi: 10.1007/s00122-010-1408-4.
  • Vaquero, L., I. Comino, S. Vivas, L. Rodríguez-Martín, M. J. Giménez, J. Pastor, C. Sousa, and F. Barro. 2018. Tritordeum: A novel cereal for food processing with good acceptability and significant reduction in gluten immunogenic peptides in comparison with wheat. Journal of the Science of Food and Agriculture 98 (6):2201–09. doi: 10.1002/jsfa.8705.
  • Verma, A. K., S. Gatti, E. Lionetti, T. Galeazzi, C. Monachesi, E. Franceschini, L. Balanzoni, N. Scattolo, M. Cinquetti, and C. Catassi. 2018. Comparison of diagnostic performance of the IgA anti-tTG test vs IgA anti-native gliadin antibodies test in detection of celiac disease in the general population. Clinical Gastroenterology and Hepatology 16 (12):1997–98. doi: 10.1016/j.cgh.2018.03.028.
  • Wacklin, P., K. Kaukinen, E. Tuovinen, P. Collin, K. Lindfors, J. Partanen, M. Mäki, and J. Mättö. 2013. The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease. Inflammatory Bowel Diseases 19 (5):934–41. doi: 10.1097/MIB.0b013e31828029a9.
  • Weichel, M., A. G. Glaser, B. K. Ballmer-Weber, P. Schmid-Grendelmeier, and R. Crameri. 2006. Wheat and maize thioredoxins: A novel cross-reactive cereal allergen family related to baker’s asthma. Journal of Allergy and Clinical Immunology 117 (3):676–81. doi: 10.1016/j.jaci.2005.11.040.
  • Wieser, H. 2007. Chemistry of gluten proteins. Food Microbiology 24 (2):115–9. doi: 10.1016/j.fm.2006.07.004.
  • Wu, J. H., B. Neal, H. Trevena, M. Crino, W. Stuart-Smith, K. Faulkner-Hogg, J. C. Yu Louie, and E. Dunford. 2015. Are gluten-free foods healthier than non-gluten-free foods? An evaluation of supermarket products in Australia. British Journal of Nutrition 114 (3):448–54. doi: 10.1017/S0007114515002056.
  • Yu, W., D. M. H. Freeland, and K. C. Nadeau. 2016. Food allergy: Immune mechanisms, diagnosis and immunotherapy. Nature Reviews Immunology 16 (12):751–65. doi: 10.1038/nri.2016.111.
  • Zanchetta, M. B., V. Longobardi, and J. C. Bai. 2016. Bone and celiac disease. Current Osteoporosis Reports 14 (2):43–8. doi: 10.1007/s11914-016-0304-5.
  • Zanini, B., V. Villanacci, L. De Leo, and A. Lanzini. 2015. Triticum monococcum in patients with celiac disease: A phase II open study on safety of prolonged daily administration. European Journal of Nutrition 54 (6):1027–9. doi: 10.1007/s00394-015-0892-3.
  • Zevallos, V. F., V. Raker, S. Tenzer, C. Jimenez-Calvente, M. Ashfaq-Khan, N. Rüssel, G. Pickert, H. Schild, K. Steinbrink, and D. Schuppan. 2017. Nutritional wheat amylase-trypsin inhibitors promote intestinal inflammation via activation of myeloid cells. Gastroenterology 152 (5):1100–13. doi: 10.1053/j.gastro.2016.12.006.

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