1,514
Views
56
CrossRef citations to date
0
Altmetric
Reviews

Recent advances in extracting phenolic compounds from food and their use in disease prevention and as cosmetics

, , , ORCID Icon &

References

  • Aaby, K., R. E. Wrolstad, D. Ekeberg, and G. Skrede. 2007. Polyphenol composition and antioxidant activity in strawberry purees; Impact of achene level and storage. Journal of Agricultural and Food Chemistry 55 (13):5156–66. doi: 10.1021/jf070467u.
  • Agarwal, B., M. J. Campen, M. M. Channell, S. J. Wherry, B. Varamini, J. G. Davis, J. A. Baur, and J. M. Smoliga. 2013. Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium. International Journal of Cardiology 166 (1):246–8. doi: 10.1016/j.ijcard.2012.09.027.
  • Alberdi, E., M. V. Sánchez-Gómez, A. Ruiz, F. Cavaliere, C. Ortiz-Sanz, T. Quintela-López, E. Capetillo-Zarate, S. Solé-Domènech, and C. Matute. 2018. Mangiferin and morin attenuate oxidative stress, mitochondrial dysfunction, and neurocytotoxicity, induced by amyloid beta oligomers. Oxidative Medicine and Cellular Longevity 2018:1–13. doi: 10.1155/2018/2856063.
  • Alvarez-Suarez, J. M., F. Giampieri, S. Tulipani, T. Casoli, G. D. Stefano, A. M. Gonzalez-Paramas, C. Santos-Buelga, F. Busco, J. L. Quiles, M. D. Cordero, et al. 2014. One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans. Journal of Nutritional Biochemistry 25 (3):289–94. doi: 10.1016/j.jnutbio.2013.11.002.
  • Amakura, Y., Y. Umino, S. Tsuji, and Y. Tonogai. 2000. Influence of jam processing on the radical scavenging activity and phenolic content in berries. Journal of Agricultural and Food Chemistry 48 (12):6292–7. doi: 10.1021/jf000849z.
  • Anal, A. K., S. Jaisanti, and A. Noomhorm. 2014. Enhanced yield of phenolic extracts from banana peels (Musa acuminata Colla AAA) and cinnamon barks (Cinnamomum varum) and their antioxidative potentials in fish oil. Journal of Food Science and Technology 51 (10):2632–9. doi: 10.1007/s13197-012-0793-x.
  • Appari, M., K. R. Babu, A. Kaczorowski, W. Gros, and I. Her. 2014. Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition. International Journal of Oncology 45 (4):1391–400. doi: 10.3892/ijo.2014.2539.
  • Arts, I. C. W., B. van de Putte, and P. C. H. Hollman. 2000. Catechin contents of foods commonly consumed in the Netherlands. 2. Tea, wine, fruit juices, and chocolate milk. Journal of Agricultural and Food Chemistry 48 (5):1752–7. doi: 10.1021/jf000026+.
  • Asami, D. K., Y. J. Hong, D. M. Barrett, and A. E. Mitchell. 2003. Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practices. Journal of Agricultural and Food Chemistry 51 (5):1237–41.
  • Austin, H. R., E. Hoss, S. F. Batie, E. W. Moffet, P. W. Jurutka, M. R. Haussler, and G. K. Whitfield. 2014. Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. Biochemical and Biophysical Research Communications 443 (4):1275–9. doi: 10.1016/j.bbrc.2013.12.128.
  • Azzini, E., J. Giacometti, and G. L. Russo. 2017. Antiobesity Effects of Anthocyanins in preclinical and clinical studies. Oxidative Medicine and Cellular Longevity 2017:1–11. doi: 10.1155/2017/2740364.
  • Bacelo, H. A. M., S. C. R. Santos, and C. M. S. Botelho. 2016. Tannin-based biosorbents for environmental applications – A review. Chemical Engineering Journal 303:575–87. doi: 10.1016/j.cej.2016.06.044.
  • Bae, J.-Y., S. S. Lim, S. J. Kim, J.-S. Choi, J. Park, S. M. Ju, S. J. Han, I.-J. Kang, and Y.-H. Kang. 2009. Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts. Molecular Nutrition & Food Research 53 (6):726–38. doi: 10.1002/mnfr.200800245.
  • Beking, K., and A. Vieira. 2010. Flavonoid intake and disability-adjusted life years due to Alzheimer’s and related dementias: A population-based study involving twenty-three developed countries. Public Health Nutrition 13 (9):1403–9. doi: 10.1017/S1368980009992990.
  • Bhullar, K. S., and H. P. V. Rupasinghe. 2013. Polyphenols: Multipotent therapeutic agents in neurodegenerative diseases. Oxidative Medicine and Cellular Longevity 2013:1–8. doi: 10.1155/2013/891748.
  • Boath, A. S., D. Grussu, D. Stewart, and G. J. McDougall. 2012. Berry polyphenols inhibit digestive enzymes: A source of potential health benefits? Food Digestion 3 (1–3):1–7. doi: 10.1007/s13228-012-0022-0.
  • Bocco, A., M.-E. Cuvelier, H. Richard, and C. Berset. 1998. Antioxidant activity and phenolic composition of citrus peel and seed extracts. Journal of Agricultural and Food Chemistry 46 (6):2123–9. doi: 10.1021/jf9709562.
  • Boussetta, N., E. Vorobiev, V. Deloison, F. Pochez, A. Falcimaigne-Cordin, and J.-L. Lanoisellé. 2011. Valorisation of grape pomace by the extraction of phenolic antioxidants: Application of high voltage electrical discharges. Food Chemistry 128 (2):364–70. doi: 10.1016/j.foodchem.2011.03.035.
  • Bryngelsson, S., B. Mannerstedt-Fogelfors, A. Kamal-Eldin, R. Andersson, and L. H. Dimberg. 2002. Lipids and antioxidants in groats and hulls of Swedish oats (Avena sativa L). Journal of the Science of Food and Agriculture 82 (6):606–14. doi: 10.1002/jsfa.1084.
  • Buonocore, D., A. Lazzeretti, P. Tocabens, V. Nobile, E. Cestone, G. Santin, M. G. Bottone, and F. Marzatico. 2012. Resveratrol–procyanidin blend: Nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Journal of Clinical and Cosmetic Dermatology 5:159–65.
  • Burg-Koorevaar, M. C. D., S. Miret, and G. S. M. J. E. Duchateau. 2011. Effect of milk and brewing method on black tea catechin bioaccessibility. Journal of Agricultural and Food Chemistry 59 (14):7752–8. doi: 10.1021/jf2015232.
  • Busto, R., J. Serna, A. Perianes-Cachero, R. Quintana-Portillo, D. García-Seisdedos, A. Canfrán-Duque, C. L. Paino, M. Lerma, M. E. Casado, A. Martín-Hidalgo, et al. 2018. Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863 (9):958–67. doi: 10.1016/j.bbalip.2018.05.009.
  • Calò, R., and L. Marabini. 2014. Protective effect of Vaccinium myrtillus extract against UVA- and UVB-induced damage in a human keratinocyte cell line (HaCaT cells). Journal of Photochemistry and Photobiology B: Biology 132(Supplement C):27–35. doi: 10.1016/j.jphotobiol.2014.01.013.
  • Calogero, G., A. Sinopoli, I. Citro, G. D. Marco, V. Petrov, A. M. Diniz, A. J. Parola, and F. Pina. 2013. Synthetic analogues of anthocyanins as sensitizers for dye-sensitized solar cells. Photochemical & Photobiological Sciences 12 (5):883–94. doi: 10.1039/c3pp25347c.
  • Carmela, S., N. Marianna, T. Idolo, M. Stefania, M. Alfonsina, and R. Gian Luigi. 2016. Neuroprotective role of natural polyphenols. Current Topics in Medicinal Chemistry 16 (17):1943–50.
  • Carmona, E., M. T. Moreno, M. Avilés, and J. Ordovas. 2012. Composting of wine industry wastes and their use as a substrate for growing soilless ornamental plants. Spanish Journal of Agricultural Research 10 (2):482–91. doi: 10.5424/sjar/2012102-320-11.
  • Castro-Acosta, M. L., G. N. Lenihan-Geels, C. P. Corpe, and W. L. Hall. 2016. Berries and anthocyanins: Promising functional food ingredients with postprandial glycaemia-lowering effects. Proceedings of the Nutrition Society 75 (3):342–55. doi: 10.1017/S0029665116000240.
  • Chamcheu, J. C., F. Afaq, D. N. Syed, I. A. Siddiqui, V. M. Adhami, N. Khan, S. Singh, B. T. Boylan, G. S. Wood, and H. Mukhtar. 2013. Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: Studies in submerged and three-dimensional epidermal equivalent models. Experimental Dermatology 22 (5):342–8. 10.1111/exd.12140. doi: 10.1111/exd.12140.
  • Chamcheu, J. C., V. M. Adhami, S. Esnault, M. Sechi, I. A. Siddiqui, K. A. Satyshur, D. N. Syed, S.-J M. Dodwad, M.-I. Chaves-Rodriquez, B. J. Longley, et al. 2017. Dual Inhibition of PI3K/Akt and mTOR by the dietary antioxidant, delphinidin, ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like disease in mice. Antioxidants & Redox Signaling 26 (2):49–69. doi: 10.1089/ars.2016.6769.
  • Chan, C.-F., C.-Y. Lien, Y.-C. Lai, C.-L. Huang, and W. C. Liao. 2010. Influence of purple sweet potato extracts on the UV absorption properties of a cosmetic cream. Journal of Cosmetic Science 61 (5):333–41.
  • Cheignon, C., M. Tomas, D. Bonnefont-Rousselot, P. Faller, C. Hureau, and F. Collin. 2018. Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox Biology 14:450–64. doi: 10.1016/j.redox.2017.10.014.
  • Chen, Y., Q. Li, T. Zhao, Z. Zhang, G. Mao, W. Feng, X. Wu, and L. Yang. 2017. Biotransformation and metabolism of three mulberry anthocyanin monomers by rat gut microflora. Food Chemistry 237:887–94. doi: 10.1016/j.foodchem.2017.06.054.
  • Cherrak, S. A., N. Mokhtari-Soulimane, F. Berroukeche, B. Bensenane, A. Cherbonnel, H. Merzouk, and M. Elhabiri. 2016. In vitro antioxidant versus metal ion chelating properties of flavonoids: A structure–activity investigation. PloS One 11 (10):e0165575. doi: 10.1371/journal.pone.0165575.
  • Cho, Y. H., A. Bahuguna, H. H. Kim, D. I. Kim, H. J. Kim, J. M. Yu, H. G. Jung, J.-Y. Jang, J. H. Kwak, G. H. Park, et al. 2017. Potential effect of compounds isolated from Coffea arabica against UV-B induced skin damage by protecting fibroblast cells. Journal of Photochemistry and Photobiology B: Biology 174:323–32. doi: 10.1016/j.jphotobiol.2017.08.015.
  • Chong, M. F., R. Macdonald, and J. A. Lovegrove. 2010. Fruit polyphenols and CVD risk: A review of human intervention studies. British Journal of Nutrition 104 (S3):S28–S39. doi: 10.1017/S0007114510003922.
  • Chung, J.-O., S.-B. Lee, K.-H. Jeong, J.-H. Song, S.-K. Kim, K.-M. Joo, H.-W. Jeong, J.-K. Choi, J.-K. Kim, W.-G. Kim, et al. 2018. Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epicatechins in in vitro and in vivo models. Food & Function 9 (1):234–42. doi: 10.1039/C7FO01576C.
  • Cong, L., C. Cao, Y. Cheng, and X.-Y. Qin. 2016. Green tea polyphenols attenuated glutamate excitotoxicity via antioxidative and antiapoptotic pathway in the primary cultured cortical neurons. Oxidative Medicine and Cellular Longevity 2016:2050435. doi: 10.1155/2016/2050435.
  • Correia, R. T., P. McCue, M. M. Magalhães, G. R. Macêdo, and K. Shetty. 2004. Production of phenolic antioxidants by the solid-state bioconversion of pineapple waste mixed with soy flour using Rhizopus oligosporus. Process Biochemistry 39 (12):2167–72. doi: 10.1016/j.procbio.2003.11.034.
  • Cortez, R., D. A. Luna-Vital, D. Margulis, and E. Gonzalez de Mejia. 2017. Natural pigments: Stabilization methods of anthocyanins for food applications. Comprehensive Reviews in Food Science and Food Safety 16 (1):180–98. doi: 10.1111/1541-4337.12244.
  • Cox, C. J., F. Choudhry, E. Peacey, M. S. Perkinton, J. C. Richardson, D. R. Howlett, S. F. Lichtenthaler, P. T. Francis, and R. J. Williams. 2015. Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiology of Aging 36 (1):178–87. doi: 10.1016/j.neurobiolaging.2014.07.032.
  • Curti, V., E. Capelli, F. Boschi, S. F. Nabavi, A. I. Bongiorno, S. Habtemariam, S. M. Nabavi, and M. Daglia. 2014. Modulation of human miR-17-3p expression by methyl 3-O-methyl gallate as explanation of its in vivo protective activities. Molecular Nutrition & Food Research 58 (9):1776–84. doi: 10.1002/mnfr.201400007.
  • Czubinski, J., and K. Dwiecki. 2017. A review of methods used for investigation of protein–phenolic compound interactions. International Journal of Food Science & Technology 52 (3):573–85. doi: 10.1111/ijfs.13339.
  • de Bock, M., J. G. Derraik, C. M. Brennan, J. B. Biggs, P. E. Morgan, S. C. Hodgkinson, P. L. Hofman, and W. S. Cutfield. 2013. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: A randomized, placebo-controlled, crossover trial. PloS One 8 (3):e57622. doi: 10.1371/journal.pone.0057622.
  • de Oliveira, A., D. Prince, C.-Y. Lo, L. H. Lee, and T.-C. Chu. 2015. Antiviral activity of theaflavin digallate against herpes simplex virus type 1. Antiviral Research 118:56–67. doi: 10.1016/j.antiviral.2015.03.009.
  • Dendrou, C. A., L. Fugger, and M. A. Friese. 2015. Immunopathology of multiple sclerosis. Nature Reviews Immunology 15 (9):545–58. doi: 10.1038/nri3871.
  • Deng, G.-F., X.-R. Xu, Y. Zhang, D. Li, R.-Y. Gan, and H.-B. Li. 2013. Phenolic compounds and bioactivities of pigmented rice. Critical Reviews in Food Science and Nutrition 53 (3):296–306. doi: 10.1080/10408398.2010.529624.
  • Diaconeasa, Z., H. Ayvaz, D. Ruginǎ, L. Leopold, A. Stǎnilǎ, C. Socaciu, F. Tăbăran, L. Luput, D. C. Mada, A. Pintea, et al. 2017. Melanoma inhibition by anthocyanins is associated with the reduction of oxidative stress biomarkers and changes in mitochondrial membrane potential. Plant Foods for Human Nutrition 72 (4):404–10. doi: 10.1007/s11130-017-0638-x.
  • Dong, X-x, Y. Wang, and Z-h Qin. 2009. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacologica Sinica 30 (4):379–87. doi: 10.1038/aps.2009.24.
  • Duarte, G. S., and A. Farah. 2011. Effect of simultaneous consumption of milk and coffee on chlorogenic acids’ bioavailability in humans. Journal of Agricultural and Food Chemistry 59 (14):7925–31. doi: 10.1021/jf201906p.
  • Edirisinghe, I., K. Banaszewski, J. Cappozzo, K. Sandhya, C. L. Ellis, R. Tadapaneni, C. T. Kappagoda, and B. M. Burton-Freeman. 2011. Strawberry anthocyanin and its association with postprandial inflammation and insulin. British Journal of Nutrition 106 (6):913–22. doi: 10.1017/S0007114511001176.
  • El Kantar, S., N. Boussetta, N. Lebovka, F. Foucart, H. N. Rajha, R. G. Maroun, N. Louka, and E. Vorobiev. 2018. Pulsed electric field treatment of citrus fruits: Improvement of juice and polyphenols extraction. Innovative Food Science & Emerging Technologies 46:153–61. doi: 10.1016/j.ifset.2017.09.024.
  • Erkkinen, M. G., M. O. Kim, and M. D. Geschwind. 2018. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harbor Perspectives in Biology 10 (4):a033118. doi: 10.1101/cshperspect.a033118.
  • Esfahlan, A. J., R. Jamei, and R. J. Esfahlan. 2010. The importance of almond (Prunus amygdalus L.) and its by-products. Food Chemistry 120 (2):349–60. doi: 10.1016/j.foodchem.2009.09.063.
  • Espinoza, J. L., L. Q. Trung, P. T. Inaoka, K. Yamada, D. T. An, S. Mizuno, S. Nakao, and A. Takami. 2017. The repeated administration of resveratrol has measurable effects on circulating T-Cell subsets in humans. Oxidative Medicine and Cellular Longevity 2017:1–10. doi: 10.1155/2017/6781872.
  • Evora, A., V. de Freitas, N. Mateus, and I. Fernandes. 2017. The effect of anthocyanins from red wine and blackberry on the integrity of a keratinocyte model using ECIS. Food & Function 8 (11):3989–98. doi: 10.1039/C7FO01239J.
  • Fang, Y., F. Liang, K. Liu, S. Qaiser, S. Pan, and X. Xu. 2018. Structure characteristics for intestinal uptake of flavonoids in Caco-2 cells. Food Research International 105:353–60. doi: 10.1016/j.foodres.2017.11.045.
  • Faria, A., D. Pestana, J. Azevedo, F. Martel, V. de Freitas, I. Azevedo, N. Mateus, and C. Calhau. 2009. Absorption of anthocyanins through intestinal epithelial cells – Putative involvement of GLUT2. Molecular Nutrition and Food Research 53 (11):7.
  • Fernández-Bolaños, J., G. Rodríguez, R. Rodríguez, R. Guillén, and A. Jiménez. 2006. Extraction of interesting organic compounds from olive oil waste. Grasas y Aceites 57 (1):95–106. doi: 10.3989/gya.2006.v57.i1.25.
  • Fernandéz-Jalao, I., C. Sánchez-Moreno, and B. de Ancos. 2017. Influence of food matrix and high-pressure processing on onion flavonols and antioxidant activity during gastrointestinal digestion. Journal of Food Engineering 213:60–8. doi: 10.1016/j.jfoodeng.2017.02.015.
  • Fernández-López, J., J. Fernández-Ginés, L. Aleson-Carbonell, E. Sendra, E. Sayas-Barberá, and J. Pérez-Alvarez. 2004. Application of functional citrus by-products to meat products. Trends in Food Science & Technology 15 (3–4):176–85. doi: 10.1016/j.tifs.2003.08.007.
  • Ferzli, G., M. Patel, N. Phrsai, and N. Brody. 2013. Reduction of facial redness with resveratrol added to topical product containing green tea polyphenols and caffeine. J Drugs Dermatol 12 (7):770–4.
  • Ficco, D. B. M., G. M. Borrelli, V. Giovanniello, C. Platani, and P. D. Vita. 2018. Production of anthocyanin-enriched flours of durum and soft pigmented wheats by air-classification, as a potential ingredient for functional bread. Journal of Cereal Science 79:118–26. doi: 10.1016/j.jcs.2017.09.007.
  • Fonseca-Kelly, Z., M. Nassrallah, J. Uribe, R. S. Khan, K. Dine, M. Dutt, and K. S. Shindler. 2012. Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Frontiers in Neurology 3:84.
  • Frade, J. G., N. R. Ferreira, R. M. Barbosa, and J. Laranjinha. 2005. Mechanisms of Neuroprotection by Polyphenols. Current Medicinal Chemistry-Central Nervous System Agents 5 (4):307–18. doi: 10.2174/156801505774913062.
  • Garrote, G., J. M. Cruz, H. Domínguez, and J. C. Parajó. 2003. Valorisation of waste fractions from autohydrolysis of selected lignocellulosic materials. Journal of Chemical Technology & Biotechnology 78 (4):392–8. doi: 10.1002/jctb.760.
  • Gasparrini, M., T. Forbes-Hernandez, S. Afrin, P. Reboredo-Rodriguez, D. Cianciosi, B. Mezzetti, J. Quiles, S. Bompadre, M. Battino, and F. Giampieri. 2017. Strawberry-based cosmetic formulations protect human dermal fibroblasts against UVA-induced damage. Nutrients 9 (6):605. doi: 10.3390/nu9060605.
  • Gauer, J. S., S. Tumova, J. D. Lippiat, A. Kerimi, and G. Williamson. 2018. Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids. Biochemical Pharmacology 152:11–20. doi: 10.1016/j.bcp.2018.03.011.
  • Gautam, S., S. Karmakar, R. Batra, P. Sharma, P. Pradhan, J. Singh, B. Kundu, and P. K. Chowdhury. 2017. Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1865 (5):589–603. doi: 10.1016/j.bbapap.2017.02.014.
  • Giacomoni, P. U. 2008. Advancement in skin aging: The future cosmeceuticals. Clinics in Dermatology 26 (4):364–6. doi: 10.1016/j.clindermatol.2008.01.006.
  • Ginwala, R., E. McTish, C. Raman, N. Singh, M. Nagarkatti, P. Nagarkatti, D. Sagar, P. Jain, and Z. K. Khan. 2016. Apigenin, a natural flavonoid, attenuates EAE severity through the modulation of dendritic cell and other immune cell functions. Journal of Neuroimmune Pharmacology 11 (1):36–47. doi: 10.1007/s11481-015-9617-x.
  • Goli, A. H., M. Barzegar, and M. A. Sahari. 2005. Antioxidant activity and total phenolic compounds of pistachio (Pistachia vera) hull extracts. Food Chemistry 92 (3):521–5. doi: 10.1016/j.foodchem.2004.08.020.
  • Gonzales, G. B., J. Van Camp, G. Smagghe, K. Raes, and A. Mackie. 2016. Flavonoid–gastrointestinal mucus interaction and its potential role in regulating flavonoid bioavailability and mucosal biophysical properties. Food Research International 88:342–7. doi: 10.1016/j.foodres.2015.12.023.
  • González-Sarrías, A., M. Á. Núñez-Sánchez, F. A. Tomás-Barberán, and J. C. Espín. 2017. Neuroprotective effects of bioavailable polyphenol-derived metabolites against oxidative stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. Journal of Agricultural and Food Chemistry 65 (4):752–8. doi: 10.1021/acs.jafc.6b04538.
  • Gorinstein, S., O. Martin‐Belloso, A. Lojek, M. Číž, R. Soliva‐Fortuny, Y. S. Park, A. Caspi, I. Libman, and S. Trakhtenberg. 2002. Comparative content of some phytochemicals in Spanish apples, peaches and pears. Journal of the Science of Food and Agriculture 82 (10):1166–70. doi: 10.1002/jsfa.1178.
  • Graham, H. N. 1992. Green tea composition, consumption, and polyphenol chemistry. Preventive Medicine 21 (3):334–50. doi: 10.1016/0091-7435(92)90041-F.
  • Guadalupe, Z., L. Martínez, and B. Ayestarán. 2010. Yeast mannoproteins in red winemaking: Effect on polysaccharide, polyphenolic, and color composition. American Journal of Enology and Viticulture 61 (2):191–200.
  • Guo, H., and W. Ling. 2015. The update of anthocyanins on obesity and type 2 diabetes: Experimental evidence and clinical perspectives. Reviews in Endocrine and Metabolic Disorders 16 (1):1–13. doi: 10.1007/s11154-014-9302-z.
  • Haghmorad, D., M. B. Mahmoudi, Z. Salehipour, Z. Jalayer, A. A. Momtazi Brojeni, M. Rastin, P. Kokhaei, and M. Mahmoudi. 2017. Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis. Journal of Neuroimmunology 302:23–33. doi: 10.1016/j.jneuroim.2016.11.009.
  • Häkkinen, S., S. Kärenlampi, H. Mykkänen, I. M. Heinonen, and A. R. Törrönen. 2000. Ellagic acid content in berries: Influence of domestic processing and storage. European Food Research and Technology 212:75–80. doi: 10.1007/s002170000184.
  • Hečimović, I., A. Belščak-Cvitanović, D. Horžić, and D. Komes. 2011. Comparative study of polyphenols and caffeine in different coffee varieties affected by the degree of roasting. Food Chemistry 129 (3):991–1000. doi: 10.1016/j.foodchem.2011.05.059.
  • He, B., J. Ge, P. Yue, X. Yue, R. Fu, J. Liang, and X. Gao. 2017a. Loading of anthocyanins on chitosan nanoparticles influences anthocyanin degradation in gastrointestinal fluids and stability in a beverage. Food Chemistry 221:1671–7. doi: 10.1016/j.foodchem.2016.10.120.
  • He, X., Z. Li, J. D. Rizak, S. Wu, Z. Wang, R. He, M. Su, D. Qin, J. Wang, and X. Hu. 2017b. Resveratrol attenuates formaldehyde induced hyperphosphorylation of Tau protein and cytotoxicity in N2a cells. Frontiers in Neuroscience 10 (598):1–11. doi: 10.3389/fnins.2016.00598.
  • Heinrich, U., C. E. Moore, S. De Spirt, H. Tronnier, and W. Stahl. 2011. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women. The Journal of Nutrition 141 (6):1202–8. doi: 10.3945/jn.110.136465.
  • Huang, D., L. Cui, S. Ahmed, F. Zainab, Q. Wu, X. Wang, and Z. Yuan. 2019. An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs. Food and Chemical Toxicology 123:574–94. doi: 10.1016/j.fct.2018.10.052.
  • Im, N. K., W. J. Jang, C. H. Jeong, and G. S. Jeong. 2014. Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kappaB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells. Journal of Medicinal Food 17 (8):855–61. doi: 10.1089/jmf.2013.3077.
  • Jakobek, L. 2015. Interactions of polyphenols with carbohydrates, lipids and proteins. Food Chemistry 175:556–67. doi: 10.1016/j.foodchem.2014.12.013.
  • Jayabalan, R., S. Marimuthu, and K. Swaminathan. 2007. Changes in content of organic acids and tea polyphenols during kombucha tea fermentation. Food Chemistry 102 (1):392–8. doi: 10.1016/j.foodchem.2006.05.032.
  • Jellinger, K. A. 2010. Basic mechanisms of neurodegeneration: A critical update. Journal of Cellular and Molecular Medicine 14 (3):457–87. doi: 10.1111/j.1582-4934.2010.01010.x.
  • Kay, C. D., G. Pereira-Caro, I. A. Ludwig, M. N. Clifford, and A. Crozier. 2017. Anthocyanins and flavanones are more bioavailable than previously perceived: A review of recent evidence. Annual Review of Food Science and Technology 8 (1):155–80. doi: 10.1146/annurev-food-030216-025636.
  • Khalid, M., R. Saeed Ur, M. Bilal, and D. F. Huang. 2019. Role of flavonoids in plant interactions with the environment and against human pathogens – A review. Journal of Integrative Agriculture 18 (1):211–30. doi: 10.1016/S2095-3119(19)62555-4.
  • Khan, M. K., M. Abert-Vian, A.-S. Fabiano-Tixier, O. Dangles, and F. Chemat. 2010. Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L.) peel. Food Chemistry 119 (2):851–8. doi: 10.1016/j.foodchem.2009.08.046.
  • Khan, M. S., T. Ali, M. W. Kim, M. H. Jo, J. I. Chung, and M. O. Kim. 2019. Anthocyanins improve hippocampus-dependent memory function and prevent neurodegeneration via JNK/Akt/GSK3beta Signaling in LPS-treated adult mice. Molecular Neurobiology 56 (1):671–87. doi: 10.1007/s12035-018-1101-1.
  • Killian, P. H., E. Kronski, K. M. Michalik, O. Barbieri, S. Astigiano, C. P. Sommerhoff, U. Pfeffer, A. G. Nerlich, and B. E. Bachmeier. 2012. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2. Carcinogenesis 33 (12):2507–19. doi: 10.1093/carcin/bgs312.
  • Kim, G. H., J. E. Kim, S. J. Rhie, and S. Yoon. 2015. The role of oxidative stress in neurodegenerative diseases. Experimental Neurobiology 24 (4):325–40. doi: 10.5607/en.2015.24.4.325.
  • Kim, J. E., M. H. Shin, and J. H. Chung. 2013. Epigallocatechin-3-gallate prevents heat shock-induced MMP-1 expression by inhibiting AP-1 activity in human dermal fibroblasts. Archives of Dermatological Research 305 (7):595–602. doi: 10.1007/s00403-013-1393-y.
  • Kim, Y. J., H. Uyama, and S. Kobayashi. 2004. Inhibition effects of (+)-catechin-aldehyde polycondensates on proteinases causing proteolytic degradation of extracellular matrix. Biochemical and Biophysical Research Communications 320 (1):256–61. doi: 10.1016/j.bbrc.2004.05.163.
  • Kiss, A., B. Bécsi, B. Kolozsvári, I. Komáromi, K. E. Kövér, and F. Erdődi. 2013. Epigallocatechin-3-gallate and penta-O-galloyl-beta-D-glucose inhibit protein phosphatase-1. FEBS Journal 280 (2):612–26. doi: 10.1111/j.1742-4658.2012.08498.x.
  • Krasinski, C. A., V. A. Ivancic, Q. Zheng, D. E. Spratt, and N. D. Lazo. 2018. Resveratrol sustains insulin-degrading enzyme activity toward Aβ42. ACS Omega 3 (10):13275–82. doi: 10.1021/acsomega.8b01913.
  • Lacroix, S., J. Klicic Badoux, M.-P. Scott-Boyer, S. Parolo, A. Matone, C. Priami, M. J. Morine, J. Kaput, and S. Moco. 2018. A computationally driven analysis of the polyphenol–protein interactome. Scientific Reports 8 (1):2232. doi: 10.1038/s41598-018-20625-5.
  • Lattanzio, V. 2013. Phenolic compounds: Introduction. Natural products: Phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes, ed. K. G. Ramawat and J.-M. Mérillon, 1543–80. Berlin, Heidelberg: Springer Berlin Heidelberg.
  • Lee, C.-J., S.-J. Moon, J.-H. Jeong, S. Lee, M.-H. Lee, S.-M. Yoo, H. S. Lee, H. C. Kang, J. Y. Lee, W. S. Lee, et al. 2018. Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis. Cell Death & Disease 9 (3):401. doi: 10.1038/s41419-018-0433-0.
  • Lee, K. K., J. J. Cho, E. J. Park, and J. D. Choi. 2001. Anti-elastase and anti-hyaluronidase of phenolic substance from Areca catechu as a new anti-ageing agent. International Journal of Cosmetic Science 23 (6):341–6. doi: 10.1046/j.0412-5463.2001.00102.x.
  • Lee, M. J., J. H. Choi, S. J. Lee, and I. H. Cho. 2017a. Oriental medicine Samhwangsasim-tang alleviates experimental autoimmune encephalomyelitis by suppressing Th1 cell responses and upregulating treg cell responses. Frontiers in Pharmacology 8 (192):1–17.
  • Lee, Y. M., Y. Yoon, H. Yoon, H. M. Park, S. Song, and K. J. Yeum. 2017b. Dietary anthocyanins against obesity and inflammation. Nutrients 9 (10):1089. doi: 10.3390/nu9101089.
  • Leu, S. J., Y. P. Lin, R. D. Lin, C. L. Wen, K. T. Cheng, F. L. Hsu, and M. H. Lee. 2006. Phenolic constituents of Malus doumeri var. formosana in the field of skin care. Biological and Pharmaceutical Bulletin 29 (4):740–5. doi: 10.1248/bpb.29.740.
  • Li, D., P. Wang, Y. Luo, M. Zhao, and F. Chen. 2017. Health benefits of anthocyanins and molecular mechanisms: Update from recent decade. Critical Reviews in Food Science and Nutrition 57 (8):1729–1741. doi: 10.1080/10408398.2015.1030064.
  • Li, Y.-R., D.-Y. Chen, C.-L. Chu, S. Li, Y.-K. Chen, C.-L. Wu, and C.-C. Lin. 2015a. Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis. The Journal of Nutritional Biochemistry 26 (12):1467–78. doi: 10.1016/j.jnutbio.2015.07.016.
  • Li, D., Y. Zhang, Y. Liu, R. Sun, and M. Xia. 2015b. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. The Journal of Nutrition 145 (4):742–8. doi: 10.3945/jn.114.205674.
  • Li, X., D. Wang, Q. C. Zhao, T. Shi, and J. Chen. 2016. Resveratrol inhibited non-small cell lung cancer through inhibiting STAT-3 signaling. The American Journal of the Medical Sciences 352 (5):524–30. doi: 10.1016/j.amjms.2016.08.027.
  • Li, Y., C. Guo, J. Yang, J. Wei, J. Xu, and S. Cheng. 2006. Evaluation of antioxidant properties of pomegranate peel extract in comparison with pomegranate pulp extract. Food Chemistry 96 (2):254–60. doi: 10.1016/j.foodchem.2005.02.033.
  • Li, Y. H., Y. Wu, H. C. Wei, Y. Y. Xu, L. L. Jia, J. Chen, X. S. Yang, G. H. Dong, X. H. Gao, and H. D. Chen. 2009. Protective effects of green tea extracts on photoaging and photommunosuppression. Skin Research and Technology 15 (3):338–45. doi: 10.1111/j.1600-0846.2009.00370.x.
  • Lipton, S. A. 2007. Pathologically-activated therapeutics for neuroprotection: Mechanism of NMDA receptor block by memantine and S-nitrosylation. Current Drug Targets 8 (5):621–32. doi: 10.2174/138945007780618472.
  • Liu, Z., T. Zhou, A. C. Ziegler, P. Dimitrion, and L. Zuo. 2017. Oxidative stress in neurodegenerative diseases: From molecular mechanisms to clinical applications. Oxidative Medicine and Cellular Longevity 2017:1–11.
  • Lu, Y., and L. Y. Foo. 1999. The polyphenol constituents of grape pomace. Food Chemistry 65 (1):1–8. doi: 10.1016/S0308-8146(98)00245-3.
  • Ma, J., Y. Li, Q. Ye, J. Li, Y. Hua, D. Ju, D. Zhang, R. Cooper, and M. Chang. 2000. Constituents of red yeast rice, a traditional Chinese food and medicine. Journal of Agricultural and Food Chemistry 48 (11):5220–25. doi: 10.1021/jf000338c.
  • Maalej, A., Z. Bouallagui, F. Hadrich, H. Isoda, and S. Sayadi. 2017. Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation. Biomedicine & Pharmacotherapy 90:179–86. doi: 10.1016/j.biopha.2017.03.034.
  • Magyar, K., R. Halmosi, A. Palfi, G. Feher, L. Czopf, A. Fulop, I. Battyany, B. Sumegi, K. Toth, and E. Szabados. 2012. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clinical Hemorheology and Microcirculation 50 (3):179–87. doi: 10.3233/CH-2011-1424.
  • Makris, D. P., G. Boskou, and N. K. Andrikopoulos. 2007. Polyphenolic content and in vitro antioxidant characteristics of wine industry and other agri-food solid waste extracts. Journal of Food Composition and Analysis 20 (2):125–32. doi: 10.1016/j.jfca.2006.04.010.
  • Martínez-Huélamo, M., A. Vallverdú-Queralt, G. Di Lecce, P. Valderas-Martínez, S. Tulipani, O. Jáuregui, E. Escribano-Ferrer, R. Estruch, M. Illan, and R. M. Lamuela-Raventós. 2016. Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial. Molecular Nutrition & Food Research 60 (7):1578–89. doi: 10.1002/mnfr.201500820.
  • Martorana, M., T. Arcoraci, L. Rizza, M. Cristani, F. P. Bonina, A. Saija, D. Trombetta, and A. Tomaino. 2013. In vitro antioxidant and in vivo photoprotective effect of pistachio (Pistacia vera L., variety Bronte) seed and skin extracts. Fitoterapia 85:41–8. doi: 10.1016/j.fitote.2012.12.032.
  • Mayta-Apaza, A. C., E. Pottgen, J. de Bodt, N. Papp, D. Marasini, L. Howard, L. Abranko, T. Van de Wiele, S.-O. Lee, and F. Carbonero. 2018. Impact of tart cherries polyphenols on the human gut microbiota and phenolic metabolites in vitro and in vivo. The Journal of Nutritional Biochemistry 59:160–72. doi: 10.1016/j.jnutbio.2018.04.001.
  • McKay, D. L., O. C. Y. Chen, C. A. Zampariello, and J. Blumberg. 2015. Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults. Food Chemistry 168:233–40. doi: 10.1016/j.foodchem.2014.07.062.
  • Megow, I., M. E. Darvin, M. C. Meinke, and J. Lademann. 2017. A randomized controlled trial of green tea beverages on the in vivo radical scavenging activity in human skin. Skin Pharmacology and Physiology 30 (5):225–33. doi: 10.1159/000477355.
  • Mennen, L. I., R. Walker, C. Bennetau-Pelissero, and A. Scalbert. 2005. Risks and safety of polyphenol consumption. The American Journal of Clinical Nutrition 81 (1):326S–329S. doi: 10.1093/ajcn/81.1.326S.
  • Milenkovic, D., B. Jude, and C. Morand. 2013. miRNA as molecular target of polyphenols underlying their biological effects. Free Radical Biology and Medicine 64:40–51. doi: 10.1016/j.freeradbiomed.2013.05.046.
  • Min, S.-Y., M. Yan, S. B. Kim, S. Ravikumar, S.-R. Kwon, K. Vanarsa, H.-Y. Kim, L. S. Davis, and C. Mohan. 2015. Green tea epigallocatechin-3-gallate suppresses autoimmune arthritis through indoleamine-2,3-dioxygenase expressing dendritic cells and the nuclear factor, erythroid 2-like 2 antioxidant pathway. Journal of Inflammation 12 (1):53. doi: 10.1186/s12950-015-0097-9.
  • Mongkholrattanasit, R., C. Klaichoi, N. Rungruangkitkrai, N. Punrattanasin, K. Sriharuksa, and M. Nakpathom. 2013. Dyeing studies with eucalyptus, quercetin, rutin, and tannin: A research on effect of ferrous sulfate mordant. Journal of Textiles 2013:1–7. doi: 10.1155/2013/423842.
  • Mudduluru, G., J. N. George-William, S. Muppala, I. A. Asangani, R. Kumarswamy, L. D. Nelson, and H. Allgayer. 2011. Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer. Bioscience Reports 31 (3):185–97. doi: 10.1042/BSR20100065.
  • Murapa, P., J. Dai, M. Chung, R. J. Mumper, and J. D'Orazio. 2012. Anthocyanin-rich fractions of blackberry extracts reduce UV-induced free radicals and oxidative damage in keratinocytes. Phytotherapy Research 26 (1):106–12. doi: 10.1002/ptr.3510.
  • Muthumani, T., and R. S. Kumar. 2007. Influence of fermentation time on the development of compounds responsible for quality in black tea. Food Chemistry 101 (1):98–102. doi: 10.1016/j.foodchem.2006.01.008.
  • Nestle, F. O., D. H. Kaplan, and J. Barker. 2009. Psoriasis. New England Journal of Medicine 361 (5):496–509. doi: 10.1056/NEJMra0804595.
  • Nwaeburu, C. C., N. Bauer, Z. Zhao, A. Abukiwan, J. Gladkich, A. Benner, and I. Herr. 2016. Up-regulation of microRNA Let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget 7 (36):58367–80. doi: 10.18632/oncotarget.11122.
  • Oliveira, D. R., P. F. Sanada, F. A. C. Saragossa, L. R. Innocenti, G. Oler, J. M. Cerutti, and S. M. Cerutti. 2009. Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: Behavioral and molecular evidence. Brain Research 1269:68–89. doi: 10.1016/j.brainres.2008.11.105.
  • Oliveira, H., I. Fernandes, N. F. Bras, A. Faria, V. De Freitas, C. Calhau, and N. Mateus. 2015. Experimental and theoretical data on the mechanism by which red wine anthocyanins are transported through a human MKN-28 gastric cell model. Journal of Agricultural and Food Chemistry 63 (35):7685–92. doi: 10.1021/acs.jafc.5b00412.
  • Oliveira, H., R. Perez-Gregorio, V. De Freitas, N. Mateus, and I. Fernandes. 2019. Comparison of the in vitro gastrointestinal bioavailability of acylated and non-acylated anthocyanins: Purple-fleshed sweet potato vs red wine. Food Chemistry 276:410–48. doi: 10.1016/j.foodchem.2018.09.159.
  • Oliveira, J., N. Mateus, and V. de Freitas. 2017. Wine-inspired chemistry: Anthocyanin transformations for a portfolio of natural colors. Synlett 28 (08):898–906. doi: 10.1055/s-0036-1589937.
  • Onyeneho, S. N., and N. S. Hettiarachchy. 1993. Antioxidant activity, fatty acids and phenolic acids compositions of potato peels. Journal of the Science of Food and Agriculture 62 (4):345–50. doi: 10.1002/jsfa.2740620406.
  • Ortega, N., J. Reguant, M. P. Romero, A. Macià, and M. J. Motilva. 2009. Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model. Journal of Agricultural and Food Chemistry 57 (13):5743–9. doi: 10.1021/jf900591q.
  • Pacheco, S. M., M. S. P. Soares, J. M. Gutierres, M. F. B. Gerzson, F. B. Carvalho, J. H. Azambuja, M. R. C. Schetinger, F. M. Stefanello, and R. M. Spanevello. 2018. Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer’s type. Journal of Nutritional Biochemistry. 56:193–204. doi: 10.1016/j.jnutbio.2018.02.014.
  • Pal, H. C., J. C. Chamcheu, V. M. Adhami, G. S. Wood, C. A. Elmets, H. Mukhtar, and F. Afaq. 2015. Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation. British Journal of Dermatology 172 (2):354–64. doi: 10.1111/bjd.13513.
  • Parasramka, M. A., E. Ho, D. E. Williams, and R. H. Dashwood. 2012. MicroRNAs, diet, and cancer: New mechanistic insights on the epigenetic actions of phytochemicals. Molecular Carcinogenesis 51 (3):213–20. doi: 10.1002/mc.20822.
  • Pathakoti, K., L. Goodla, M. Manubolu, and T. Tencomnao. 2017. Metabolic alterations and the protective effect of punicalagin against glutamate-induced oxidative toxicity in HT22 Cells. Neurotoxicity Research 31 (4):521–31. doi: 10.1007/s12640-016-9697-2.
  • Paz-Yépez, C., I. Peinado, A. Heredia, and A. Andrés. 2019. Lipids digestibility and polyphenols release under in vitro digestion of dark, milk and white chocolate. Journal of Functional Foods 52:196–203. doi: 10.1016/j.jff.2018.10.028.
  • Pérez-Gregorio, M., J. Regueiro, E. Alonso-González, L. Pastrana-Castro, and J. Simal-Gándara. 2011a. Influence of alcoholic fermentation process on antioxidant activity and phenolic levels from mulberries (Morus nigra L.). Lwt - Food Science and Technology 44 (8):1793–801. doi: 10.1016/j.lwt.2011.03.007.
  • Pérez-Gregorio, M., J. Regueiro, C. González-Barreiro, R. Rial-Otero, and J. Simal-Gándara. 2011b. Changes in antioxidant flavonoids during freeze-drying of red onions and subsequent storage. Food Control 22 (7):1108–13. doi: 10.1016/j.foodcont.2011.01.006.
  • Pérez-Gregorio, M. R., M. S. García-Falcón, and J. Simal-Gándara. 2011. Flavonoids changes in fresh-cut onions during storage in different packaging systems. Food Chemistry 124 (2):652–8. doi: 10.1016/j.foodchem.2010.06.090.
  • Pérez-Gregorio, R., and J. Simal-Gándara. 2017. A critical review of bioactive food components, and of their functional mechanisms, biological effects and health outcomes. Current Pharmaceutical Design 23 (19):2731–41.
  • Perez-Sanchez, A., E. Barrajon-Catalan, N. Caturla, J. Castillo, O. Benavente-Garcia, M. Alcaraz, and V. Micol. 2014. Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. Journal of Photochemistry and Photobiology B: Biology 136:12–8. doi: 10.1016/j.jphotobiol.2014.04.007.
  • Petersen, B., S. Egert, A. Bosy-Westphal, M. J. Müller, S. Wolffram, E. M. Hubbermann, G. Rimbach, and K. Schwarz. 2016. Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources. Food Research International 88:159–65. doi: 10.1016/j.foodres.2016.02.013.
  • Phetpornpaisan, P., P. Tippayawat, M. Jay, and K. Sutthanut. 2014. A local Thai cultivar glutinous black rice bran: A source of functional compounds in immunomodulation, cell viability and collagen synthesis, and matrix metalloproteinase-2 and -9 inhibition. Journal of Functional Foods 7 (Supplement C):650–61. doi: 10.1016/j.jff.2013.12.020.
  • Pineda-Vadillo, C., F. Nau, C. Guerin-Dubiard, J. Jardin, V. Lechevalier, M. Sanz-Buenhombre, A. Guadarrama, T. Toth, E. Csavajda, H. Hingyi, et al. 2017. The food matrix affects the anthocyanin profile of fortified egg and dairy matrices during processing and in vitro digestion. Food Chemistry. 214:486–96. doi: 10.1016/j.foodchem.2016.07.049.
  • Poewe, W., K. Seppi, C. M. Tanner, G. M. Halliday, P. Brundin, J. Volkmann, A.-E. Schrag, and A. E. Lang. 2017. Parkinson disease. Nature Reviews Disease Primers 3 (1):17013. doi: 10.1038/nrdp.2017.13.
  • Potapovich, A. I., V. A. Kostyuk, T. V. Kostyuk, C. de Luca, and L. G. Korkina. 2013. Effects of pre- and post-treatment with plant polyphenols on human keratinocyte responses to solar UV. Inflammation Research 62 (8):773–80. doi: 10.1007/s00011-013-0634-z.
  • Pratheeshkumar, P.,. Y.-O. Son, S. P. Divya, L. Wang, L. Turcios, R. V. Roy, J. A. Hitron, D. Kim, J. Dai, P. Asha, et al. 2017. Quercetin inhibits Cr (VI)-induced malignat cell transformation by targeting miR-21-PDCD4 signaling pathway. Oncotarget 8 (32):52118–31. doi: 10.18632/oncotarget.10130.
  • Quijada-Morín, N., P. Williams, J. Rivas-Gonzalo, T. Doco, and M. T. Escribano-Bailon. 2014. Polyphenolic, polysaccharide and oligosaccharide composition of Tempranillo red wines and their relationship with the perceived astringency. Food Chemistry 154:44–51. doi: 10.1016/j.foodchem.2013.12.101.
  • Ramarathnam, N., T. Osawa, M. Namiki, and S. Kawakishi. 1988. Chemical studies on novel rice hull antioxidants. 1. Isolation, fractionation, and partial characterization. Journal of Agricultural and Food Chemistry 36 (4):732–7. doi: 10.1021/jf00082a014.
  • Renouf, M., C. Marmet, P. Guy, A.-L. Fraering, K. Longet, J. Moulin, M. Enslen, D. Barron, C. Cavin, F. Dionisi, et al. 2010. Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. The Journal of Nutrition 140 (2):259–63. doi: 10.3945/jn.109.113027.
  • Ribnicky, D. M., D. E. Roopchand, A. Oren, M. Grace, A. Poulev, M. A. Lila, R. Havenaar, and I. Raskin. 2014. Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). Food Chemistry 142:349–57. doi: 10.1016/j.foodchem.2013.07.073.
  • Riccio, P. 2011. The molecular basis of nutritional intervention in multiple sclerosis: A narrative review. Complementary Therapies in Medicine 19 (4):228–37. doi: 10.1016/j.ctim.2011.06.006.
  • Rios-Hoyo, A., M. J. Cortes, H. Rios-Ontiveros, E. Meaney, G. Ceballos, and G. Gutierrez-Salmean. 2014. Obesity, metabolic syndrome, and dietary therapeutical approaches with a special focus on nutraceuticals (polyphenols): A mini-review. International Journal for Vitamin and Nutrition Research 84 (3–4):113–23.
  • Roberfroid, M. B. 2000. Concepts and strategy of functional food science: The European perspective. The American Journal of Clinical Nutrition 71 (6):1660s–64s. doi: 10.1093/ajcn/71.6.1660S.
  • Rodrigues, A. S., M. R. Pérez-Gregorio, M. S. García-Falcón, J. Simal-Gándara, and D. P. F. Almeida. 2011. Effect of meteorological conditions on antioxidant flavonoids in Portuguese cultivars of white and red onions. Food Chemistry 124 (1):303–8. doi: 10.1016/j.foodchem.2010.06.037.
  • Roh, E., J.-E. Kim, J. Y. Kwon, J. S. Park, A. M. Bode, Z. Dong, and K. W. Lee. 2017. Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging. Critical Reviews in Food Science and Nutrition 57 (8):1631–37. doi: 10.1080/10408398.2014.1003365.
  • Rojo, L. E., D. Ribnicky, S. Logendra, A. Poulev, P. Rojas-Silva, P. Kuhn, R. Dorn, M. H. Grace, M. A. Lila, and I. Raskin. 2012. In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chemistry 131 (2):387–96. doi: 10.1016/j.foodchem.2011.08.066.
  • Roopchand, D. E., P. Kuhn, L. E. Rojo, M. A. Lila, and I. Raskin. 2013. Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice. Pharmacological Research 68 (1):59–67. 10.1016/j.phrs.2012.1011.1008. doi: 10.1016/j.phrs.2012.11.008.
  • Sarubbo, F., S. Esteban, A. Miralles, and D. Moranta. 2018. Effects of resveratrol and other polyphenols on Sirt1: Relevance to brain function during aging. Current Neuropharmacology 16 (2):126–36. doi: 10.2174/1570159X15666170703113212.
  • Schweiger, S., F. Matthes, K. Posey, E. Kickstein, S. Weber, M. M. Hettich, S. Pfurtscheller, D. Ehninger, R. Schneider, and S. Krauß. 2017. Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Scientific Reports 7 (1):13753. doi: 10.1038/s41598-017-12974-4.
  • Sengul, H., E. Surek, and D. Nilufer-Erdil. 2014. Investigating the effects of food matrix and food components on bioaccessibility of pomegranate (Punica granatum) phenolics and anthocyanins using an in-vitro gastrointestinal digestion model. Food Research International 62:1069–79. doi: 10.1016/j.foodres.2014.05.055.
  • Serra, A., A. Macià, M.-P. Romero, J. Valls, C. Bladé, L. Arola, and M.-J. Motilva. 2010. Bioavailability of procyanidin dimers and trimers and matrix food effects in vitro and in vivo models. British Journal of Nutrition 103 (7):944–52. doi: 10.1017/S0007114509992741.
  • Shahid, M., F. Khan, and A. Ahern. 2018. Review of A paradigm shift to prevent and treat Alzheimer’s Disease: From monotargeting pharmaceuticals to pleiotropic plant polyphenols A paradigm shift to prevent and treat Alzheimer’s Disease: From monotargeting pharmaceuticals to pleiotropic plant polyphenols, by Howard Friel and Sally Frautschy. Academic Press. 2017. 290 pp. $199.90. ISBN 9780128122594. Journal of Natural Products 81 (9):2159–60. doi: 10.1021/acs.jnatprod.8b00686.
  • Shankar, E., R. Kanwal, M. Candamo, and S. Gupta. 2016. Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges. Seminars in Cancer Biology 40–41:82–99. doi: 10.1016/j.semcancer.2016.04.002.
  • Sigurdson, G. T., A. Atnip, J. Bomser, and M. M. Giusti. 2018. Aglycone structures and glycosylations affect anthocyanin transport and uptake in human gastric epithelial (NCI-N87) cells. Journal of Food Composition and Analysis 65:33–9. doi: 10.1016/j.jfca.2017.09.007.
  • Silva, P., and D. Vauzour. 2018. Wine polyphenols and neurodegenerative diseases: An update on the molecular mechanisms underpinning their protective effects. Beverages 4 (4):96. doi: 10.3390/beverages4040096.
  • Smith, P., J. McRae, and K. Bindon. 2015. Impact of winemaking practices on the concentration and composition of tannins in red wine. Australian Journal of Grape and Wine Research 21:601–14. doi: 10.1111/ajgw.12188.
  • Spanos, G. A., R. E. Wrolstad, and D. A. Heatherbell. 1990. Influence of processing and storage on the phenolic composition of apple juice. Journal of Agricultural and Food Chemistry 38 (7):1572–79.
  • Srivastava, S. K., S. Arora, C. Averett, S. Singh, and A. P. Singh. 2015. Modulation of microRNAs by phytochemicals in cancer: Underlying mechanisms and translational significance. Biomed Research International 2015:1–9. doi: 10.1155/2015/848710.
  • Stadlbauer, S., P. Rios, K. Ohmori, K. Suzuki, and M. Köhn. 2015. Procyanidins negatively affect the activity of the phosphatases of regenerating liver. Plos One 10 (7):e0134336. doi: 10.1371/journal.pone.0134336.
  • Stanisavljević, N., J. Samardžić, T. Janković, K. Šavikin, M. Mojsin, V. Topalović, and M. Stevanović. 2015. Antioxidant and antiproliferative activity of chokeberry juice phenolics during in vitro simulated digestion in the presence of food matrix. Food Chemistry 175:516–22. doi: 10.1016/j.foodchem.2014.12.009.
  • Stebbins, N. B., L. R. Howard, R. L. Prior, C. Brownmiller, and A. Mauromoustakos. 2017. Stabilization of anthocyanins in blackberry juice by glutathione fortification. Food & Function 8 (10):3459–68. doi: 10.1039/C7FO00801E.
  • Sudha, M., V. Baskaran, and K. Leelavathi. 2007. Apple pomace as a source of dietary fiber and polyphenols and its effect on the rheological characteristics and cake making. Food Chemistry 104 (2):686–92. doi: 10.1016/j.foodchem.2006.12.016.
  • Sun, J.-X., X.-F. Sun, R.-C. Sun, P. Fowler, and M. S. Baird. 2003. Inhomogeneities in the chemical structure of sugarcane bagasse lignin. Journal of Agricultural and Food Chemistry 51 (23):6719–25. doi: 10.1021/jf034633j.
  • Sun, Q., Y. Zheng, X. Zhang, X. Hu, Y. Wang, S. Zhang, D. Zhang, and H. Nie. 2013. Novel immunoregulatory properties of EGCG on reducing inflammation in EAE. Frontiers in Bioscience 18 (1):332–42. doi: 10.2741/4104.
  • Teng, H., and L. Chen. 2019. Polyphenols and bioavailability: An update. Critical Reviews in Food Science and Nutrition 59 (13):2040–51. doi: 10.1080/10408398.2018.1437023.
  • Teoli, F., S. Lucioli, P. Nota, A. Frattarelli, F. Matteocci, A. D. Carlo, E. Caboni, and C. Forni. 2016. Role of pH and pigment concentration for natural dye-sensitized solar cells treated with anthocyanin extracts of common fruits. Journal of Photochemistry and Photobiology A: Chemistry 316:24–30. doi: 10.1016/j.jphotochem.2015.10.009.
  • Thal, D. R., and M. Fandrich. 2015. Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD. Acta Neuropathologica 129 (2):163–5. doi: 10.1007/s00401-015-1387-2.
  • Thompson, A. J., S. E. Baranzini, J. Geurts, B. Hemmer, and O. Ciccarelli. 2018. Multiple sclerosis. The Lancet 391 (10130):1622–36. doi: 10.1016/S0140-6736(18)30481-1.
  • Thring, T. S., P. Hili, and D. P. Naughton. 2009. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complementary and Alternative Medicine 9 (1):27. doi: 10.1186/1472-6882-9-27.
  • Tome-Carneiro, J., and F. Visioli. 2016. Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence. Phytomedicine 23 (11):1145–74. doi: 10.1016/j.phymed.2015.10.018.
  • Tsao, R. 2010. Chemistry and biochemistry of dietary polyphenols. Nutrients 2 (12):1231–46. doi: 10.3390/nu2121231.
  • Udompataikul, M., P. Sripiroj, and P. Palungwachira. 2009. An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles. International Journal of Cosmetic Science 31 (6):427–35. doi: 10.1111/j.1468-2494.2009.00513.x.
  • Upadhyay, S., and M. Dixit. 2015. Role of polyphenols and other phytochemicals on molecular signaling. Oxidative Medicine and Cellular Longevity 2015:1–15. doi: 10.1155/2015/504253.
  • Vaisman, N., and E. Niv. 2015. Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: A double blind, placebo-controlled, randomized study. International Journal of Food Science and Nutrition 66 (3):342–9. doi: 10.3109/09637486.2014.1000840.
  • van der Sluis, A. A., M. Dekker, G. Skrede, and W. M. F. Jongen. 2002. Activity and concentration of polyphenolic antioxidants in apple juice. 1. Effect of existing production methods. Journal of Agricultural and Food Chemistry 50 (25):7211–19. doi: 10.1021/jf020115h.
  • van der Sluis, A. A., M. Dekker, and M. A. J. S. van Boekel. 2005. Activity and concentration of polyphenolic antioxidants in apple juice. 3. Stability during Storage. Journal of Agricultural and Food Chemistry 53 (4):1073–80. doi: 10.1021/jf040270r.
  • Vauzour, D. 2012. Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects. Oxidative Medicine and Cellular Longevity 2012:914273. doi: 10.1155/2012/914273.
  • Vauzour, D., S. Corsini, M. Müller, and J. P. E. Spencer. 2018. Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons. Archives of Biochemistry and Biophysics 650:14–21. doi: 10.1016/j.abb.2018.04.020.
  • Vidoni, C., E. Secomandi, A. Castiglioni, M. A. B. Melone, and C. Isidoro. 2018. Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation. Neurochemistry International 117:174–87. doi: 10.1016/j.neuint.2017.05.013.
  • Wang, F., J. Gong, X. Zhang, Y. Ren, and J. Zhang. 2018. Preparation of biocolorant and eco-dyeing derived from polyphenols based on laccase-catalyzed oxidative polymerization. Polymers 10 (2):196. doi: 10.3390/polym10020196.
  • Wang, H., P. Li, and W. Zhou. 2014. Dyeing of silk with anthocyanins dyes extract from Liriope platyphylla Fruits. Journal of Textiles 2014:1–9. doi: 10.1155/2014/587497.
  • Wang, J., Y. Qi, X. Niu, H. Tang, S. N. Meydani, and D. Wu. 2018. Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice. The Journal of Nutritional Biochemistry 54:130–9. doi: 10.1016/j.jnutbio.2017.12.004.
  • Wang, J., Z. Ren, Y. Xu, S. Xiao, S. N. Meydani, and D. Wu. 2012. Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-Cell Subsets. The American Journal of Pathology 180 (1):221–34. doi: 10.1016/j.ajpath.2011.09.007.
  • Wang, R., and P. H. Reddy. 2017. Role of Glutamate and NMDA Receptors in Alzheimer’s disease. Journal of Alzheimer's Disease 57 (4):1041–8. doi: 10.3233/JAD-160763.
  • Wang, Y., A. P. Singh, H. N. Nelson, A. J. Kaiser, N. C. Reker, T. L. Hooks, T. Wilson, and N. Vorsa. 2016. Urinary clearance of cranberry flavonol glycosides in humans. Journal of Agricultural and Food Chemistry 64 (42):7931–9. doi: 10.1021/acs.jafc.6b03611.
  • Warford, J., Q. R. D. Jones, M. Nichols, V. Sullivan, H. P. V. Rupasinghe, and G. S. Robertson. 2014. The flavonoid-enriched fraction AF4 suppresses neuroinflammation and promotes restorative gene expression in a mouse model of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 268 (1–2):71–83. doi: 10.1016/j.jneuroim.2014.01.007.
  • Watanabe, M., Y. Ohshita, and T. Tsushida. 1997. Antioxidant Compounds from buckwheat (Fagopyrum esculentum Möench) Hulls. Journal of Agricultural and Food Chemistry 45 (4):1039–44. doi: 10.1021/jf9605557.
  • Williamson, G. 2017. The role of polyphenols in modern nutrition. Nutrition Bulletin 42 (3):226–35. doi: 10.1111/nbu.12278.
  • Wu, L., L. Guo, Y. Liang, X. Liu, L. Jiang, and L. Wang. 2015. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncology Reports 34 (6):3311–7. doi: 10.3892/or.2015.4279.
  • Wu, P.-Y., C.-C. Huang, Y. Chu, Y.-H. Huang, P. Lin, Y.-H. Liu, K.-C. Wen, C.-Y. Lin, M.-C. Hsu, and H.-M. Chiang. 2017. Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica extract in human skin fibroblasts and hairless mouse skin. International Journal of Molecular Sciences 18 (4):782. doi: 10.3390/ijms18040782.
  • Wyss-Coray, T., and J. Rogers. 2012. Inflammation in Alzheimer disease – A brief review of the basic science and clinical literature. Cold Spring Harbor Perspectives in Medicine 2 (1):a006346. doi: 10.1101/cshperspect.a006346.
  • Xu, Q., M. Langley, A. G. Kanthasamy, and M. B. Reddy. 2017. Epigallocatechin gallate has a neurorescue effect in a mouse model of Parkinson Disease. The Journal of Nutrition 147 (10):1926–31. doi: 10.3945/jn.117.255034.
  • Yamate, Y., K. Hiramoto, and E. F. Sato. 2017. The preventive effect of coffee compounds on dermatitis and epidermal pigmentation after ultraviolet irradiation in mice. Skin Pharmacology and Physiology 30 (1):24–35. doi: 10.1159/000455237.
  • Yamaura, K., M. Ishiwatari, M. Yamamoto, M. Shimada, Y. Bi, and K. Ueno. 2012. Anthocyanins, but not Anthocyanidins, from Bilberry (Vaccinium myrtillus L.) Alleviate pruritus via inhibition of mast cell degranulation. Journal of Food Science 77 (12):H262–67. doi: 10.1111/j.1750-3841.2012.02974.x.
  • Yang, J. E., K. Y. Rhoo, S. Lee, J. T. Lee, J. H. Park, G. Bhak, and S. R. Paik. 2017. EGCG-mediated protection of the membrane disruption and cytotoxicity caused by the ‘Active Oligomer’ of α-Synuclein. Scientific Reports 7 (1):17945. doi: 10.1038/s41598-017-18349-z.
  • Yang, L., W. Ling, Y. Yang, Y. Chen, Z. Tian, Z. Du, J. Chen, Y. Xie, Z. Liu, and L. Yang. 2017. Role of purified anthocyanins in improving cardiometabolic risk factors in Chinese men and women with prediabetes or early untreated diabetes – A randomized controlled trial. Nutrients 9 (10):1104. doi: 10.3390/nu9101104.
  • Yang, X., P. Si, H. Qin, L. Yin, L.-J. Yan, and C. Zhang. 2017. The Neuroprotective Effects of SIRT1 on NMDA-induced excitotoxicity. Oxidative Medicine and Cellular Longevity 2017:1–11. doi: 10.1155/2017/2823454.
  • Yang, Y., X. Zhang, M. Xu, X. Wu, F. Zhao, and C. Zhao. 2018. Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. International Immunopharmacology 54:153–62. doi: 10.1016/j.intimp.2017.11.013.
  • Zeliou, K., V. Papasotiropoulos, Y. Manoussopoulos, and F. N. Lamari. 2018. Physical and chemical quality characteristics and antioxidant properties of strawberry cultivars (Fragaria × ananassa Duch.) in Greece: Assessment of their sensory impact. Journal of the Science of Food and Agriculture 98 (11):4065–73. doi: 10.1002/jsfa.8923.
  • Zhang, L. F., X. L. Yu, M. Ji, S. Y. Liu, X. L. Wu, Y. J. Wang, and R. T. Liu. 2018. Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson’s disease. Food & Function 9 (12):6414–26. doi: 10.1039/C8FO00964C.
  • Zhang, S., and R. Zhang. 2014. Effects of microwave pretreatment of apple raw material on the nutrients and antioxidant activities of apple juice. Journal of Food Processing 2014:1–9. doi: 10.1155/2014/824050.
  • Zhang, Y., X. Li, B. Ciric, C. G. Ma, B. Gran, A. Rostami, and G. X. Zhang. 2015. Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway. Scientific Reports 5 (1):17407. doi: 10.1038/srep17407.
  • Zhao, X., W. Zhang, X. Yin, M. Su, C. Sun, X. Li, and K. Chen. 2015. Phenolic composition and antioxidant properties of different peach [Prunus persica (L.) Batsch] cultivars in China. International Journal of Molecular Sciences 16 (12):5762–78. doi: 10.3390/ijms16035762.
  • Zhong, Z., Z. Dong, L. Yang, X. Chen, and Z. Gong. 2012. Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7. Experimental and Therapeutic Medicine 4 (2):267–72. doi: 10.3892/etm.2012.580.
  • Zhu, K., and W. Wang. 2016. Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1. Tumor Biology 37 (4):4373–82. doi: 10.1007/s13277-015-4187-3.
  • Zhu, Y., M. Xia, Y. Yang, F. Liu, Z. Li, Y. Hao, M. Mi, T. Jin, and W. Ling. 2011. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clinical Chemistry 57 (11):1524–33. doi: 10.1373/clinchem.2011.167361.
  • Zoric, N., N. Kopjar, K. Kraljic, N. Orsolic, S. Tomic, and I. Kosalec. 2016. Olive leaf extract activity against Candida albicans and C. dubliniensis – The in vitro viability study. Acta Pharmaceutica 66 (3):411–21. doi: 10.1515/acph-2016-0033.
  • Zunino, S. J., J. M. Peerson, T. L. Freytag, A. P. Breksa, E. L. Bonnel, L. R. Woodhouse, and D. H. Storms. 2014. Dietary grape powder increases IL-1beta and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans. British Journal of Nutrition 112 (3):369–80. doi: 10.1017/S0007114514000890.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.