References
- Abdul Manas, N. H., R. Md Illias, and N. M. Mahadi. 2018. Strategy in manipulating transglycosylation activity of glycosyl hydrolase for oligosaccharide production. Critical Reviews in Biotechnology 38 (2):272–93. doi: https://doi.org/10.1080/07388551.2017.1339664.
- Alpers D. H. 2003. Carbohydrates/Digestion, absorption, and metabolism. In: Encyclopedia of Food Sciences and Nutrition, ed. B. Caballero, 2nd ed., 881–887. Cambridge, MA: Elsevier.
- Barroso, E., C. Cueva, C. Peláez, M. C. Martínez-Cuesta, and T. Requena. 2015. Development of human colonic microbiota in the computer-controlled dynamic SIMulator of the GastroIntestinal tract SIMGI. LWT - Food Science and Technology 61 (2):283–9. doi: https://doi.org/10.1016/j.lwt.2014.12.014.
- Barroso, E., A. Montilla, N. Corzo, C. Peláez, M. C. Martínez-Cuesta, and T. Requena. 2016. Effect of lactulose-derived oligosaccharides on intestinal microbiota during the shift between media with different energy contents. Food Research International 89 (Pt 1):302–8. doi: https://doi.org/10.1016/j.foodres.2016.08.025.
- Bellmann, S., M. Minekus, P. Sanders, S. Bosgra, and R. Havenaar. 2018. Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitro gastrointestinal digestion with in silico kinetic modeling. Clinical Nutrition Experimental 17:8–22. doi: https://doi.org/10.1016/j.yclnex.2017.10.003.
- Bohn, T., F. Carriere, L. Day, A. Deglaire, L. Egger, D. Freitas, M. Golding, S. Le Feunteun, A. Macierzanka, O. Menard, et al. 2018. Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models? Critical Reviews in Food Science and Nutrition 58 (13):2239–61. doi: https://doi.org/10.1080/10408398.2017.1315362.
- Brodkorb, A., L. Egger, M. Alminger, P. Alvito, R. Assunção, S. Ballance, T. Bohn, C. Bourlieu-Lacanal, R. Boutrou, F. Carrière, et al. 2019. INFOGEST static in vitro simulation of gastrointestinal food digestion. Nature Protocols 14 (4):991–1014. doi: https://doi.org/10.1038/s41596-018-0119-1.
- Cardelle-Cobas, A., N. Corzo, A. Olano, C. Peláez, T. Requena, and M. Ávila. 2011. Galactooligosaccharides derived from lactose and lactulose: Influence of structure on Lactobacillus, Streptococcus and Bifidobacterium growth. International Journal of Food Microbiology 149 (1):81–7. doi: https://doi.org/10.1016/j.ijfoodmicro.2011.05.026.
- Cardelle-Cobas, A., A. Olano, N. Corzo, M. Villamiel, M. Collins, S. Kolida, and R. A. Rastall. 2012. In vitro fermentation of lactulose-derived oligosaccharides by mixed fecal microbiota. Journal of Agricultural and Food Chemistry 60 (8):2024–32. doi: https://doi.org/10.1021/jf203622d.
- Carnachan, S. M., T. J. Bootten, S. Mishra, J. A. Monro, and I. M. Sims. 2012. Effects of simulated digestion in vitro on cell wall polysaccharides from kiwifruit (Actinidia spp.). Food Chemistry 133 (1):132–9. doi: https://doi.org/10.1016/j.foodchem.2011.12.084.
- Chen, G., M. Xie, P. Wan, D. Chen, H. Ye, L. Chen, X. Zeng, and Z. Liu. 2018. Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea. Food Chemistry 244:331–9. doi: https://doi.org/10.1016/j.foodchem.2017.10.074.
- Chen, L., W. Xu, D. Chen, G. Chen, J. Liu, X. Zeng, R. Shao, and H. Zhu. 2018. Digestibility of sulfated polysaccharide from the brown seaweed Ascophyllum nodosum and its effect on the human gut microbiota in vitro. International Journal of Biological Macromolecules 112:1055–61. doi: https://doi.org/10.1016/j.ijbiomac.2018.01.183.
- Di, T., G. Chen, Y. Sun, S. Ou, X. Zeng, and H. Ye. 2018. In vitro digestion by saliva, simulated gastric and small intestinal juices and fermentation by human fecal microbiota of sulfated polysaccharides from Gracilaria rubra. Journal of Functional Foods 40:18–27. doi: https://doi.org/10.1016/j.jff.2017.10.040.
- Díez-Municio, M., M. Herrero, A. Olano, and F. J. Moreno. 2014. Synthesis of novel bioactive lactose-derived oligosaccharides by microbial glycoside hydrolases. Microbial Biotechnology 7 (4):315–31. doi: https://doi.org/10.1111/1751-7915.12124.
- Donaldson, G. P., S. M. Lee, and S. K. Mazmanian. 2016. Gut biogeography of the bacterial microbiota. Nature Reviews Microbiology 14 (1):20–32. doi: https://doi.org/10.1038/nrmicro3552.
- Drechsler, K. C., and G. M. Bornhorst. 2018. Modeling the softening of carbohydrate-based foods during simulated gastric digestion. Journal of Food Engineering 222:38–48. doi: https://doi.org/10.1016/j.jfoodeng.2017.11.007.
- Dupont, D., M. Alric, S. Blanquet-Diot, G. Bornhorst, C. Cueva, A. Deglaire, S. Denis, M. Ferrua, R. Havenaar, J. Lelieveld, et al. 2019. Can dynamic in vitro digestion systems mimic the physiological reality? Critical Reviews in Food Science and Nutrition 59 (10):1546–62. doi: https://doi.org/10.1080/10408398.2017.1421900.
- Egger, L., O. Ménard, C. Delgado-Andrade, P. Alvito, R. Assunção, S. Balance, R. Barberá, A. Brodkorb, T. Cattenoz, A. Clemente, et al. 2016. The harmonized INFOGEST in vitro digestion method: From knowledge to action. Food Research International 88:217–25. doi: https://doi.org/10.1016/j.foodres.2015.12.006.
- Egger, L., P. Schlegel, C. Baumann, H. Stoffers, D. Guggisberg, C. Brügger, D. Dürr, P. Stoll, G. Vergères, and R. Portmann. 2017. Physiological comparability of the harmonized INFOGEST in vitro digestion method to in vivo pig digestion. Food Research International 102:567–74. doi: https://doi.org/10.1016/j.foodres.2017.09.047.
- Englyst, H., H. S. Wiggins, and J. H. Cummings. 1982. Determination of the non-starch polysaccharides in plant foods by gas-liquid chromatography of constituent sugars as alditol acetates. The Analyst 107 (1272):307–18. doi: https://doi.org/10.1039/an9820700307.
- Fernández, J., F. J. Moreno, A. Olano, A. Clemente, C. J. Villar, and F. Lombó. 2018. A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model. Frontiers in Microbiology 9:1–14. doi: https://doi.org/10.3389/fmicb.2018.02004.
- Ferreira-Lazarte, A., P. Gallego-Lobillo, F. J. Moreno, M. Villamiel, and O. Hernández-Hernández. 2019. In vitro digestibility of galactooligosaccharides: Effect of the structural features on their intestinal degradation. Journal of Agricultural and Food Chemistry 67 (16):4662–70. doi: https://doi.org/10.1021/acs.jafc.9b00417.
- Ferreira-Lazarte, A., A. Montilla, A.-I. Mulet-Cabero, N. Rigby, A. Olano, A. Mackie, and M. Villamiel. 2017. Study on the digestion of milk with prebiotic carbohydrates in a simulated gastrointestinal model. Journal of Functional Foods 33:149–54. doi: https://doi.org/10.1016/j.jff.2017.03.031.
- Ferreira-Lazarte, A., F. J. Moreno, C. Cueva, I. Gil-Sánchez, and M. Villamiel. 2019. Behaviour of citrus pectin during its gastrointestinal digestion and fermentation in a dynamic simulator (simgi®). Carbohydrate Polymers 207:382–90. doi: https://doi.org/10.1016/j.carbpol.2018.11.088.
- Ferreira-Lazarte, A., A. Olano, M. Villamiel, and F. J. Moreno. 2017. Assessment of in vitro digestibility of dietary carbohydrates using rat small intestinal extract. Journal of Agricultural and Food Chemistry 65 (36):8046–53. doi: https://doi.org/10.1021/acs.jafc.7b01809.
- Foucault, M., J. Singh, R. B. Stewart, and H. Singh. 2016. Pilot scale production and in vitro gastro-small intestinal digestion of self-assembled recrystallised starch (SARS) structures. Journal of Food Engineering 191:95–7. doi: https://doi.org/10.1016/j.jfoodeng.2016.07.001.
- Gallego-Lobillo, P., A. Ferreira-Lazarte, O. Hernández-Hernández, A. Montilla, and M. Villamiel. 2020. Evaluation of the impact of a rat small intestinal extract on the digestion of four different functional fibers. Food & function 11 (5):4081–9. doi: https://doi.org/10.1039/d0fo00236d.
- Gallego-Lobillo, P., A. Ferreira-Lazarte, O. Hernández-Hernández, and M. Villamiel. 2020. Kinetic study on the digestibility of lactose and lactulose using small intestinal glycosidases. Food Chemistry 316:126326. doi: https://doi.org/10.1016/j.foodchem.2020.126326.
- Garcia-Campayo, V., S. Han, R. Vercauteren, and A. Franck. 2018. Digestion of food ingredients and food using an in vitro model integrating intestinal mucosal enzymes. Food and Nutrition Sciences 9 (6):711–34. doi: https://doi.org/10.4236/fns.2018.96055.
- Gibson, G. R., R. Hutkins, M. E. Sanders, S. L. Prescott, R. A. Reimer, S. J. Salminen, K. Scott, C. Stanton, K. S. Swanson, P. D. Cani, et al. 2017. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology 14 (8):491–502. doi: https://doi.org/10.1038/nrgastro.2017.75.
- Goodman, B. E. 2010. Insights into digestion and absorption of major nutrients in humans. Advances in Physiology Education 34 (2):44–53. doi: https://doi.org/10.1152/advan.00094.2009.
- Guinane, C. M., and P. D. Cotter. 2013. Role of the gut microbiota in health and chronic gastrointestinal disease: Understanding a hidden metabolic organ. Therapeutic Advances in Gastroenterology 6 (4):295–308. doi: https://doi.org/10.1177/1756283X13482996.
- Gullón, B., B. Gómez, M. Martínez-Sabajanes, R. Yáñez, J. C. Parajó, and J. L. Alonso. 2013. Pectic oligosaccharides: Manufacture and functional properties. Trends in Food Science & Technology 30 (2):153–61. doi: https://doi.org/10.1016/j.tifs.2013.01.006.
- Han, R., D. Pang, L. Wen, L. You, R. Huang, and V. Kulikouskaya. 2020. In vitro digestibility and prebiotic activities of a sulfated polysaccharide from Gracilaria Lemaneiformis. Journal of Functional Foods 64:103652. doi: https://doi.org/10.1016/j.jff.2019.103652.
- Heinritz, S. N., R. Mosenthin, and E. Weiss. 2013. Use of pigs as a potential model for research into dietary modulation of the human gut microbiota. Nutrition Research Reviews 26 (2):191–209. doi: https://doi.org/10.1017/S0954422413000152.
- Hernández-Hernández, O. 2019. In vitro gastrointestinal models for prebiotic carbohydrates: A critical review. Current Pharmaceutical Design 25 (32):3478–6. doi: https://doi.org/10.2174/1381612825666191011094724.
- Hernández-Hernández, O., M. C. Marin-Manzano, L. A. Rubio, F. J. Moreno, M. L. Sanz, and A. Clemente. 2012. Monomer and linkage type of galacto-oligosaccharides affect their resistance to ileal digestion and prebiotic properties in rats. The Journal of Nutrition 142 (7):1232–9. doi: https://doi.org/10.3945/jn.111.155762.
- Hernández-Hernández, O., A. Olano, R. A. Rastall, and F. J. Moreno. 2019. In vitro digestibility of dietary carbohydrates: Toward a standardized methodology beyond amylolytic and microbial enzymes. Frontiers in Nutrition 6:61. doi: https://doi.org/10.3389/fnut.2019.00061.
- Holloway, W. D., C. Tasman-Jones, and K. Maher. 1983. Pectin digestion in humans. The American journal of clinical nutrition 37 (2):253–5. doi: https://doi.org/10.1093/ajcn/37.2.253.
- Holmes, R., and R. W. Lobley. 1989. Intestinal brush border revisited. Gut 30 (12):1667–78. doi: https://doi.org/10.1136/gut.30.12.1667.
- Hooton, D., R. Lentle, J. Monro, M. Wickham, and R. Simpson. 2015. The secretion and action of brush border enzymes in the mammalian small intestine. Reviews of Physiology, Biochemistry and Pharmacology 168:59–118. doi: https://doi.org/10.1007/112_2015_24.
- Hu, Y., V. Winter, X. Y. Chen, and M. G. Gänzle. 2017. Effect of acceptor carbohydrates on oligosaccharide and polysaccharide synthesis by dextransucrase DsrM from Weissella cibaria. Food Research International 99 (Pt 1):603–11. doi: https://doi.org/10.1016/j.foodres.2017.06.026.
- Humphray, S. J., C. E. Scott, R. Clark, B. Marron, C. Bender, N. Camm, J. Davis, A. Jenks, A. Noon, M. Patel, et al. 2007. A high utility integrated map of the pig genome. Genome Biology 8 (7):R139. doi: https://doi.org/10.1186/gb-2007-8-7-r139.
- Ito, S., H. Taguchi, S. Hamada, S. Kawauchi, H. Ito, T. Senoura, J. Watanabe, M. Nishimukai, S. Ito, and H. Matsui. 2008. Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme. Applied Microbiology and Biotechnology 79 (3):433–41. doi: https://doi.org/10.1007/s00253-008-1449-7.
- Jandhyala, S. M., R. Talukdar, C. Subramanyam, H. Vuyyuru, M. Sasikala, and D. Nageshwar Reddy. 2015. Role of the normal gut microbiota. World Journal of Gastroenterology 21 (29):8787–803. doi: https://doi.org/10.3748/wjg.v21.i29.8787.
- Jantscher-Krenn, E., C. Marx, and L. Bode. 2013. Human milk oligosaccharides are differentially metabolised in neonatal rats. The British Journal of Nutrition 110 (4):640–50. doi: https://doi.org/10.1017/S0007114512005727.
- Jenkins, D. J., M. J. Thorne, K. Camelon, A. Jenkins, A. V. Rao, R. H. Taylor, L. U. Thompson, J. Kalmusky, R. Reichert, and T. Francis. 1982. Effect of processing on digestibility and the blood glucose response: A study of lentils. The American Journal of Clinical Nutrition 36 (6):1093–101. doi: https://doi.org/10.1093/ajcn/36.6.1093.
- Jensen, T. W., M. J. Mazur, J. E. Pettigew, V. G. Perez-Mendoza, J. Zachary, and L. B. Schook. 2010. A cloned pig model for examining atherosclerosis induced by high fat, high cholesterol diets. Animal Biotechnology 21 (3):179–87. doi: https://doi.org/10.1080/10495398.2010.490693.
- Julio-Gonzalez, L. C., O. Hernández-Hernández, F. J. Moreno, A. Olano, M. L. Jimeno, and N. Corzo. 2019. Trans-β-galactosidase activity of pig enzymes embedded in the small intestinal brush border membrane vesicles. Scientific Reports 9 (1):960. doi: https://doi.org/10.1038/s41598-018-37582-8.
- Julio-Gonzalez, L. C., O. Hernández-Hernández, F. J. Moreno, M. L. Jimeno, E. García, A. Olano, and N. Corzo. 2020. Hydrolysis and transgalactosylation catalysed by β-galactosidase from brush border membrane vesicles isolated from pig small intestine: A study using lactulose and its mixtures with lactose or galactose as substrates. Food Research International (Ottawa, Ont.) 129:108811. doi: https://doi.org/10.1016/j.foodres.2019.108811.
- Kaulpiboon, J., P. Rudeekulthamrong, S. Watanasatitarpa, K. Ito, and P. Pongsawasdi. 2015. Synthesis of long-chain isomaltooligosaccharides from tapioca starch and an in vitro investigation of their prebiotic properties. Journal of Molecular Catalysis B: Enzymatic 120:127–35. doi: https://doi.org/10.1016/j.molcatb.2015.07.004.
- Khodaei, N., B. Fernandez, I. Fliss, and S. Karboune. 2016. Digestibility and prebiotic properties of potato rhamnogalacturonan I polysaccharide and its galactose-rich oligosaccharides/oligomers. Carbohydrate polymers 136:1074–84. doi: https://doi.org/10.1016/j.carbpol.2015.09.106.
- Kopf-Bolanz, K. A., F. Schwander, M. Gijs, G. Verge, R. Portmann, and L. Egger. 2012. Validation of an in vitro digestive system for studying macronutrient decomposition in humans. The Journal of Nutrition 142 (2):245–50. doi: https://doi.org/10.3945/jn.111.148635.
- Kuzmuk, K. 2009. Animal models for elucidating human disease: Confronting cancer and other chronic diseases. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 4:1–9.
- Kuzmuk, K. N., and L. B. Schook. 2011. Pigs as a model for biomedical sciences. In The genetics of the pig, ed. M. F. Rothschild and A. Ruvinsky, 2nd ed., 426–44. Wallingford, UK: CABI Publishing.
- Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, K. Dewar, M. Doyle, and W. FitzHugh. 2001. Initial sequencing and analysis of the human genome. Nature 409:860–921.
- Laparra, J. M., M. Diez-Municio, M. Herrero, and F. J. Moreno. 2014. Structural differences of prebiotic oligosaccharides influence their capability to enhance iron absorption in deficient rats. Food & Function 5 (10):2430–7. doi: https://doi.org/10.1039/c4fo00504j.
- Larsen, N., C. Bussolo de Souza, L. Krych, T. Barbosa Cahú, M. Wiese, W. Kot, K. M. Hansen, A. Blennow, K. Venema, and L. Jespersen. 2019. Potential of pectins to beneficially modulate the gut microbiota depends on their structural properties. Frontiers in Microbiology 10:223–13. doi: https://doi.org/10.3389/fmicb.2019.00223.
- Lee, B.-H., D. R. Rose, A. H.-M. Lin, R. Quezada-Calvillo, B. L. Nichols, and B. R. Hamaker. 2016. Contribution of the individual small intestinal α-glucosidases to digestion of unusual α-linked glycemic disaccharides. Journal of Agricultural and Food Chemistry 64 (33):6487–94. doi: https://doi.org/10.1021/acs.jafc.6b01816.
- Leemhuis, H., J. M. Dobruchowska, M. Ebbelaar, F. Faber, P. L. Buwalda, M. J. E. C. Van Der Maarel, J. P. Kamerling, and L. Dijkhuizen. 2014. Isomalto/malto-polysaccharide, a novel soluble dietary fiber made via enzymatic conversion of starch. Journal of Agricultural and Food Chemistry 62 (49):12034–44. doi: https://doi.org/10.1021/jf503970a.
- Lerner, A., S. Neidhöfer, and T. Matthias. 2017. The gut microbiome feelings of the brain: A perspective for non-microbiologists. Microorganisms 5 (4):66–24. doi: https://doi.org/10.3390/microorganisms5040066.
- Li, W., K. Wang, Y. Sun, H. Ye, B. Hu, and X. Zeng. 2015. Influences of structures of galactooligosaccharides and fructooligosaccharides on the fermentation in vitro by human intestinal microbiota. Journal of Functional Foods 13:158–68. doi: https://doi.org/10.1016/j.jff.2014.12.044.
- Lifschitz, C. H., M. A. Grusak, and N. F. Butte. 2002. Human nutrition and metabolism carbohydrate digestion in humans from a β-Glucan-enriched barley. The Journal of Nutrition 132 (9):2593–6. doi: https://doi.org/10.1093/jn/132.9.2593.
- Logan, K., A. J. Wright, and H. D. Goff. 2015. Correlating the structure and in vitro digestion viscosities of different pectin fibers to in vivo human satiety. Food & Function 6 (1):63–71. doi: https://doi.org/10.1039/c4fo00543k.
- Lombard, V., H. Golaconda Ramulu, E. Drula, P. M. Coutinho, and B. Henrissat. 2014. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Research 42:D490–5. doi: https://doi.org/10.1093/nar/gkt1178.
- López-Sanz, S., A. Montilla, F. J. Moreno, and M. Villamiel. 2015. Stability of oligosaccharides derived from lactulose during the processing of milk and apple juice. Food Chemistry 183:64–71. doi: https://doi.org/10.1016/j.foodchem.2015.03.020.
- López-Sanz, S., R. Moreno, M. J. De La Mata, F. J. Moreno, and M. Villamiel. 2018. Stability of oligosaccharides derived from lactose and lactulose regarding rheological and thermal properties. Journal of Food Quality 2018:1–9. doi: https://doi.org/10.1155/2018/7597301.
- McCleary, B., J. Rader, M. Champ, and K. Okuma. 2010. Determination of total dietary fiber (CODEX definition) by enzymatic-gravimetric method and liquid chromatography. Journal of AOAC International 93 (1):221–33.
- McCleary, B. V., N. Sloane, and A. Draga. 2015. Determination of total dietary fibre and available carbohydrates: A rapid integrated procedure that simulates in vivo digestion. Starch - Stärke 67 (9–10):860–83. doi: https://doi.org/10.1002/star.201500017.
- McConnell, R. E., J. N. Higginbotham, D. A. Shifrin, D. L. Tabb, R. J. Coffey, and M. J. Tyska. 2009. The enterocyte microvillus is a vesicle-generating organelle. The Journal of Cell Biology 185 (7):1285–98. doi: https://doi.org/10.1083/jcb.200902147.
- Meisenberg, G., and W. H. Simmons. 2016. Digestive enzymes. In: Principles of Medical Biochemistry, ed. G. Meisenberg and W. H. Simmons, 4th ed., 342–350. Amsterdam: Elsevier.
- Míguez, B., B. Gómez, P. Gullón, B. Gullón. And J. L. Alonso. 2016. Pectic oligosaccharides and other emerging prebiotics. In Probiotics and prebiotics in human nutrition and health, eds. V. Rao and L. Rao, 301–30. London, UK: InTechOpen.
- Minekus, M., M. Alminger, P. Alvito, S. Ballance, T. Bohn, C. Bourlieu, F. Carrière, R. Boutrou, M. Corredig, D. Dupont, et al. 2014. A standardised static in vitro digestion method suitable for food – An international consensus. Food & Function 5 (6):1113–24. doi: https://doi.org/10.1039/c3fo60702j.
- Minekus, M., P. Marteau, R. Havenaar, and J. H. J. Huis in’t Veld. 1995. A multicompartmental dynamic computer-controlled model simulating the stomach and small intestine. Alternatives to Laboratory Animals 23:197–209.
- Molis, C., B. Flourié, F. Ouarne, M. F. Gailing, S. Lartigue, A. Guibert, F. Bornet, and J. P. Galmiche. 1996. Digestion, excretion, and energy value of fructooligosaccharides in healthy humans. The American Journal of Clinical Nutrition 64 (3):324–8. doi: https://doi.org/10.1093/ajcn/64.3.324.
- Molly, K., M. Vande Woestyne, and W. Verstraete. 1993. Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Applied Microbiology and Biotechnology 39 (2):254–8. doi: https://doi.org/10.1007/BF00228615.
- Moon, J. S., W. Joo, L. Ling, H. S. Choi, and N. S. Han. 2016. In vitro digestion and fermentation of sialyllactoses by infant gut microflora. Journal of Functional Foods 21:497–506. doi: https://doi.org/10.1016/j.jff.2015.12.002.
- Nobre, C., S. C. Sousa, S. P. Silva, A. C. Pinheiro, E. Coelho, A. A. Vicente, A. M. P. Gomes, M. A. Coimbra, J. A. Teixeira, and L. R. Rodrigues. 2018. In vitro digestibility and fermentability of fructo-oligosaccharides produced by Aspergillus ibericus. Journal of Functional Foods 46:278–87. doi: https://doi.org/10.1016/j.jff.2018.05.004.
- Ohtsuka, K., K. Tsuji, Y. Nakagawa, H. Ueda, O. Ozawa, T. Uchida, and T. Ichikawa. 1990. Availability of 4'galactosyllactose (O-beta-D-galactopyranosyl-(1). Journal of Nutritional Science and Vitaminology 36 (3):265–76. doi: https://doi.org/10.3177/jnsv.36.265.
- Oku, T., K. Tanabe, S. Ogawa, N. Sadamori, and S. Nakamura. 2011. Similarity of hydrolyzing activity of human and rat small intestinal disaccharidases. Clinical and Experimental Gastroenterology 4:155–61. doi: https://doi.org/10.2147/CEG.S19961.
- Oku, T., T. Tokunaga, and N. Hosoya. 1984. Nondigestibility of a new sweetener, “Neosugar,” in the rat. The Journal of Nutrition 114 (9):1574–81. doi: https://doi.org/10.1093/jn/114.9.1574.
- Ouwehand, A. C., and E. E. Vaughan. 2006. Gastrointestinal microbiology. New York, NY: Taylor & Francis.
- Park, M. O., M. Chandrasekaran, and S. H. Yoo. 2019. Production and characterization of low-calorie turanose and digestion-resistant starch by an amylosucrase from Neisseria subflava. Food Chemistry 300:125225. doi: https://doi.org/10.1016/j.foodchem.2019.125225.
- Picariello, G., P. Ferranti, and F. Addeo. 2016. Use of brush border membrane vesicles to simulate the human intestinal digestion. Food Research International 88:327–35. doi: https://doi.org/10.1016/j.foodres.2015.11.002.
- Rastall, R. A., G. R. Gibson, H. S. Gill, F. Guarner, T. R. Klaenhammer, B. Pot, G. Reid, I. R. Rowland, and M. E. Sanders. 2005. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS Microbiology Ecology 52 (2):145–52. doi: https://doi.org/10.1016/j.femsec.2005.01.003.
- Rui, Y., P. Wan, G. Chen, M. Xie, Y. Sun, X. Zeng, and Z. Liu. 2019. Simulated digestion and fermentation in vitro by human gut microbiota of intra- and extra-cellular polysaccharides from Aspergillus cristatus. LWT - Food Science and Technology 116:108508. doi: https://doi.org/10.1016/j.lwt.2019.108508.
- Saito, D., S. Nakaji, S. Fukuda, T. Shimoyama, J. Sakamoto, and K. Sugawara. 2005. Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin. Nutrition (Burbank, Los Angeles County, Calif.) 21 (9):914–9. doi: https://doi.org/10.1016/j.nut.2005.01.005.
- Sancho, R. A. S., J. D. R. P. Souza, F. A. de Lima, and G. M. Pastore. 2017. Evaluation of oligosaccharide profiles in selected cooked tubers and roots subjected to in vitro digestion. LWT - Food Science and Technology 76:270–7. doi: https://doi.org/10.1016/j.lwt.2016.07.046.
- Schook, L. B., T. V. Collares, K. A. Darfour-Oduro, A. K. De, L. A. Rund, K. M. Schachtschneider, and F. K. Seixas. 2015. Unraveling the swine genome: Implications for human health. Annual Review of Animal Biosciences 3:219–44. doi: https://doi.org/10.1146/annurev-animal-022114-110815.
- Shi, Y., J. Liu, Q. Yan, X. You, S. Yang, and Z. Jiang. 2018. In vitro digestibility and prebiotic potential of curdlan (1→3)-β-d-glucan oligosaccharides in Lactobacillus species. Carbohydrate Polymers 188:17–26. doi: https://doi.org/10.1016/j.carbpol.2018.01.085.
- Shin, H., D. H. Seo, J. Seo, L. M. Lamothe, S. H. Yoo, and B. H. Lee. 2019. Optimization of in vitro carbohydrate digestion by mammalian mucosal α-glucosidases and its applications to hydrolyze the various sources of starches. Food Hydrocolloids 87:470–6. doi: https://doi.org/10.1016/j.foodhyd.2018.08.033.
- Sivieri, K., M. L. V. Morales, S. M. I. Saad, M. A. T. Adorno, I. K. Sakamoto, and E. A. Rossi. 2014. Prebiotic effect of fructo-oligosaccharides in the simulator of the human intestinal microbial ecosystem (SHIME® model). Journal of Medicinal Food 17 (8):894–901. doi: https://doi.org/10.1089/jmf.2013.0092.
- Southgate, D. A. T. 1969. Determination of carbohydrates in foods I. – Available carbohydrate. Journal of the Science of Food and Agriculture 20:326–30.
- Strube, M. L., T. K. Jensen, A. S. Meyer, and M. Boye. 2015. In situ prebiotics: Enzymatic release of galacto-rhamnogalacturonan from potato pulp in vivo in the gastrointestinal tract of the weaning piglet. AMB Express 5 (1):8. doi: https://doi.org/10.1186/s13568-015-0152-1.
- Tanabe, K., S. Nakamura, and T. Oku. 2014. Inaccuracy of AOAC method 2009.01 with amyloglucosidase for measuring non-digestible oligosaccharides and proposal for an improvement of the method. Food Chemistry 151:539–46. doi: https://doi.org/10.1016/j.foodchem.2013.11.121.
- Tanabe, K., S. Nakamura, K. Omagari, and T. Oku. 2015. Determination trial of nondigestible oligosaccharide in processed foods by improved AOAC Method 2009.01 using porcine small intestinal enzyme. Journal of Agricultural and Food Chemistry 63 (24):5747–52. doi: https://doi.org/10.1021/jf505844y.
- Tornero-Martínez, A., R. Cruz-Ortiz, M. E. Jaramillo-Flores, P. Osorio-Díaz, S. V. Ávila-Reyes, G. M. Alvarado-Jasso, and R. Mora-Escobedo. 2019. In vitro fermentation of polysaccharides from Aloe vera and the evaluation of antioxidant activity and production of short chain fatty acids. Molecules 24 (19):3605. doi: https://doi.org/10.3390/molecules24193605.
- Turnbull, C. M., A. L. Baxter, and S. K. Johnson. 2005. Water-binding capacity and viscocity of Australian sweet lupin kernel fibre under in vitro conditions simulating the human upper gastrointestinal tract. International Journal of Food Sciences and Nutrition 56 (2):87–94. doi: https://doi.org/10.1080/09637480500081080.
- Verhoeckx, K., K. L. Bøgh, D. Dupont, L. Egger, G. Gadermaier, C. Larré, A. Mackie, O. Menard, K. Adel-Patient, G. Picariello, et al. 2019. The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST. Food and Chemical Toxicology 129:405–23. doi: https://doi.org/10.1016/j.fct.2019.04.052.
- Villamiel, M., A. Montilla, A. Olano, and N. Corzo. 2014. Production and bioactivity of oligosaccharides derived from lactose. In Food oligosaccharides: Production, analysis and bioactivity, eds. F. J. Moreno and M. L. Sanz, 135–67. Hoboken, NJ: Wiley.
- Villanueva-Millán, M. J., P. Pérez-Matute, and J. A. Oteo. 2015. Gut microbiota: A key player in health and disease. A review focused on obesity. Journal of Physiology and Biochemistry 71 (3):509–25. doi: https://doi.org/10.1007/s13105-015-0390-3.
- Woolnough, J. W., J. A. Monro, C. S. Brennan, and A. R. Bird. 2008. Simulating human carbohydrate digestion in vitro: A review of methods and the need for standardisation. International Journal of Food Science & Technology 43 (12):2245–56. doi: https://doi.org/10.1111/j.1365-2621.2008.01862.x.
- Wang, L., C. Li, Q. Huang, X. Fu, and R. H. Liu. 2019. In vitro digestibility and prebiotic potential of a novel polysaccharide from Rosa roxburghii Tratt fruit. Journal of Functional Foods 52:408–17. doi: https://doi.org/10.1016/j.jff.2018.11.021.
- Wang, Y., G. Chen, Y. Peng, Y. Rui, X. Zeng, and H. Ye. 2019. Simulated digestion and fermentation in vitro with human gut microbiota of polysaccharides from Coralline pilulifera. LWT - Food Science and Technology 100:167–74. doi: https://doi.org/10.1016/j.lwt.2018.10.028.
- Yang, Y., C. Zhao, M. Diao, S. Zhong, M. Sun, B. Sun, H. Ye, and T. Zhang. 2018. The prebiotic activity of simulated gastric and intestinal digesta of polysaccharides from the Hericium erinaceus. Molecules 23 (12):3158–14. doi: https://doi.org/10.3390/molecules23123158.