References
- Al-Tamimi, M. A., R. J. Palframan, J. M. Cooper, G. R. Gibson, and R. A. Rastall. 2006. In vitro fermentation of sugar beet arabinan and arabino-oligosaccharides by the human gut microflora. Journal of Applied Microbiology 100 (2):407–14. doi: https://doi.org/10.1111/j.1365-2672.2005.02780.x.
- Anderson, K. L., and A. A. Salyers. 1989. Biochemical evidence that starch breakdown by Bacteroides thetaiotaomicron involves outer membrane starch-binding sites and periplasmic starch-degrading enzymes. Journal of Bacteriology 171 (6):3192–8. doi: https://doi.org/10.1128/JB.171.6.3192-3198.1989.
- Armstrong, Z., K. Mewis, F. Liu, C. Morgan-Lang, M. Scofield, E. Durno, H. M. Chen, K. Mehr, S. G. Withers, and S. J. Hallam. 2018. Metagenomics reveals functional synergy and novel polysaccharide utilization loci in the Castor canadensis fecal microbiome. The ISME Journal 12 (11):2757–69. doi: https://doi.org/10.1038/s41396-018-0215-9.
- Arrieta, M. C., L. T. Stiemsma, P. A. Dimitriu, L. Thorson, S. Russell, S. Yurist-Doutsch, B. Kuzeljevic, M. J. Gold, H. M. Britton, D. L. Lefebvre, et al. 2015. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Science Translational Medicine 7 (307):152–307. doi: https://doi.org/10.1126/scitranslmed.aab2271.
- Babbar, N., W. Dejonghe, M. Gatti, S. Sforza, and K. Elst. 2016. Pectic oligosaccharides from agricultural by-products: Production, characterization and health benefits. Critical Reviews in Biotechnology 36 (4):594–606. doi: https://doi.org/10.3109/07388551.2014.996732.
- Backhed, F., R. E. Ley, J. L. Sonnenburg, D. A. Peterson, and J. I. Gordon. 2005. Host-bacterial mutualism in the human intestine. Science (New York, N.Y.) 307 (5717):1915–20. doi: https://doi.org/10.1126/science.1104816.
- Barcena, C., R. Valdes-Mas, P. Mayoral, C. Garabaya, S. Durand, F. Rodriguez, M. T. Fernandez-Garcia, N. Salazar, A. M. Nogacka, N. Garatachea, et al. 2019. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nature Medicine 25 (8):1234–42. doi: https://doi.org/10.1038/s41591-019-0504-5.
- Bashir, K. M. I., and J. S. Choi. 2017. Clinical and physiological perspectives of beta-glucans: The past, present, and future. International Journal of Molecular Sciences 18 (9):1906. doi: https://doi.org/10.3390/ijms18091906.
- Bindels, L. B., R. R. S. Munoz, J. C. Gomes-Neto, V. Mutemberezi, I. Martinez, N. Salazar, E. A. Cody, M. I. Quintero-Villegas, H. Kittana, C. G. de los Reyes-Gavilan, et al. 2017. Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome 5 (1):12. doi: https://doi.org/10.1186/s40168-017-0230-5.
- Birt, D. F., T. Boylston, S. Hendrich, J. L. Jane, J. Hollis, L. Li, J. McClelland, S. Moore, G. J. Phillips, M. Rowling, et al. 2013. Resistant starch: Promise for improving human health. Advances in Nutrition (Bethesda, Md.) 4 (6):587–601. doi: https://doi.org/10.3945/an.113.004325.
- Bjursell, M. K., E. C. Martens, and J. I. Gordon. 2006. Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period. The Journal of Biological Chemistry 281 (47):36269–79. doi: https://doi.org/10.1074/jbc.M606509200.
- Bolam, D. N., and N. M. Koropatkin. 2012. Glycan recognition by the Bacteroidetes Sus-like systems. Current Opinion in Structural Biology 22 (5):563–9. doi: https://doi.org/10.1016/j.sbi.2012.06.006.
- Borchani, C., F. Fonteyn, G. Jamin, J. Destain, L. Willems, M. Paquot, C. Blecker, and P. Thonart. 2016. Structural characterization, technological functionality, and physiological aspects of fungal β-D-glucans: A review. Critical Reviews in Food Science and Nutrition 56 (10):1746–52. doi: https://doi.org/10.1080/10408398.2013.854733.
- Bowyer, R. C. E., M. A. Jackson, T. Pallister, J. Skinner, T. D. Spector, A. A. Welch, and C. J. Steves. 2018. Use of dietary indices to control for diet in human gut microbiota studies. Microbiome 6 (1):77. doi: https://doi.org/10.1186/s40168-018-0455-y.
- Caffall, K. H., and D. Mohnen. 2009. The structure, function, and biosynthesis of plant cell wall pectic polysaccharides. Carbohydrate Research 344 (14):1879–900. doi: https://doi.org/10.1016/j.carres.2009.05.021.
- Cai, Y., J. Folkerts, G. Folkerts, M. Maurer, and S. Braber. 2020. Microbiota-dependent and -independent effects of dietary fibre on human health. British Journal of Pharmacology 177 (6):1363–810. doi: https://doi.org/10.1111/bph.14871.
- Cartmell, A., E. C. Lowe, A. Basle, S. J. Firbank, D. A. Ndeh, H. Murray, N. Terrapon, V. Lombard, B. Henrissat, J. E. Turnbull, et al. 2017. How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proceedings of the National Academy of Sciences of the United States of America 114 (27):7037–42. doi: https://doi.org/10.1073/pnas.1704367114.
- Cartmell, A., L. S. McKee, M. J. Pena, J. Larsbrink, H. Brumer, S. Kaneko, H. Ichinose, R. J. Lewis, A. Vikso-Nielsen, H. J. Gilbert, et al. 2011. The structure and function of an arabinan-specific alpha-1,2-arabinofuranosidase identified from screening the activities of bacterial GH43 glycoside hydrolases. The Journal of Biological Chemistry 286 (17):15483–95. doi: https://doi.org/10.1074/jbc.M110.215962.
- Cartmell, A., J. Munoz-Munoz, J. A. Briggs, D. A. Ndeh, E. C. Lowe, A. Basle, N. Terrapon, K. Stott, T. Heunis, J. Gray, et al. 2018. A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nature Microbiology 3 (11):1314–26. doi: https://doi.org/10.1038/s41564-018-0258-8.
- Cerqueira, F. M., A. L. Photenhauer, R. M. Pollet, H. A. Brown, and N. M. Koropatkin. 2020. Starch digestion by gut bacteria: Crowdsourcing for carbs. Trends in Microbiology 28 (2):95–108. doi: https://doi.org/10.1016/j.tim.2019.09.004.
- Chae, J. S., H. Shin, Y. Song, H. Kang, C. H. Yeom, S. Lee, and Y. S. Choi. 2019. Yeast (1 → 3)-(1 → 6)-β-d-glucan alleviates immunosuppression in gemcitabine-treated mice. International Journal of Biological Macromolecules 136:1169–75. doi: https://doi.org/10.1016/j.ijbiomac.2019.06.009.
- Chang, C. J., T. L. Lin, Y. L. Tsai, T. R. Wu, W. F. Lai, C. C. Lu, and H. C. Lai. 2019. Next generation probiotics in disease amelioration. Journal of Food and Drug Analysis 27 (3):615–22. doi: https://doi.org/10.1016/j.jfda.2018.12.011.
- Choi, W. I., Y. Hwang, A. Sahu, K. Min, D. Sung, G. Tae, and J. H. Chang. 2018. An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation. Biomaterials Science 6 (10):2627–38. doi: https://doi.org/10.1039/c8bm00524a.
- Comstock, L. E. 2009. Importance of glycans to the host-bacteroides mutualism in the mammalian intestine. Cell Host & Microbe 5 (6):522–6. doi: https://doi.org/10.1016/j.chom.2009.05.010.
- Correa-Ferreira, M. L., D. M. Ferreira, J. L. Dallazen, A. M. S. Silva, M. F. P. Werner, and C. L. O. Petkowicz. 2018. Gastroprotective effects and structural characterization of a pectic fraction isolated from Artemisia campestris subsp maritima. International Journal of Biological Macromolecules 107 (Pt B):2395–403. doi: https://doi.org/10.1016/j.ijbiomac.2017.10.127.
- Corti, F., Y. Wang, J. M. Rhodes, D. Atri, S. Archer-Hartmann, J. Zhang, Z. W. Zhuang, D. Chen, T. Wang, Z. Wang, et al. 2019. N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization. Nature Communications 10 (1):1562. doi: https://doi.org/10.1038/s41467-019-09605-z.
- Cuskin, F., E. C. Lowe, M. J. Temple, Y. P. Zhu, E. A. Cameron, N. A. Pudlo, N. T. Porter, K. Urs, A. J. Thompson, A. Cartmell, et al. 2015. Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature 520 (7547):388. doi: https://doi.org/10.1038/nature14334.
- D'Elia, J. N., and A. A. Salyers. 1996. Effect of regulatory protein levels on utilization of starch by Bacteroides thetaiotaomicron. Journal of Bacteriology 178 (24):7180–6. doi: https://doi.org/10.1128/jb.178.24.7180-7186.1996.
- Delangle, A., A. F. Prouvost, V. Cogez, J. P. Bohin, J. M. Lacroix, and N. H. Cotte-Pattat. 2007. Characterization of the Erwinia chrysanthemi Gan locus, involved in galactan catabolism. Journal of Bacteriology 189 (19):7053–61. doi: https://doi.org/10.1128/JB.00845-07.
- DeMartino, P., and D. W. Cockburn. 2020. Resistant starch: Impact on the gut microbiome and health. Current Opinion in Biotechnology 61:66–71. doi: https://doi.org/10.1016/j.copbio.2019.10.008.
- Domzal-Kedzia, M., A. Lewinska, A. Jaromin, M. Weselski, R. Pluskota, and M. Lukaszewicz. 2019. Fermentation parameters and conditions affecting levan production and its potential applications in cosmetics. Bioorganic Chemistry 93:102787. doi: https://doi.org/10.1016/j.bioorg.2019.02.012.
- Douillard, F. P., and W. M. de Vos. 2019. Biotechnology of health-promoting bacteria. Biotechnology Advances 37 (6):107369. doi: https://doi.org/10.1016/j.biotechadv.2019.03.008.
- Eckburg, P. B., E. M. Bik, C. N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, S. R. Gill, K. E. Nelson, and D. A. Relman. 2005. Diversity of the human intestinal microbial flora. Science (New York, N.Y.) 308 (5728):1635–8. doi: https://doi.org/10.1126/science.1110591.
- El Kaoutari, A., F. Armougom, J. I. Gordon, D. Raoult, and B. Henrissat. 2013. The abundance and variety of carbohydrate-active enzymes in the human gut microbiota. Nature Reviews. Microbiology 11 (7):497–504. doi: https://doi.org/10.1038/nrmicro3050.
- Englyst, H. N., S. M. Kingman, and J. H. Cummings. 1992. Classification and measurement of nutritionally important starch fractions. European Journal of Clinical Nutrition 46 (Suppl 2):S33–S50.
- Ernits, K., P. Eek, T. Lukk, T. Visnapuu, and T. Alamae. 2019. First crystal structure of an endo-levanase – The BT1760 from a human gut commensal Bacteroides thetaiotaomicron. Scientific Reports 9 (1):8443. doi: https://doi.org/10.1038/s41598-019-44785-0.
- Faith, J. J., J. L. Guruge, M. Charbonneau, S. Subramanian, H. Seedorf, A. L. Goodman, J. C. Clemente, R. Knight, A. C. Heath, R. L. Leibel, et al. 2013. The long-term stability of the human gut microbiota. Science (New York, N.Y.) 341 (6141):1237439. doi: https://doi.org/10.1126/science.1237439.
- Fan, Y., L. Sun, S. Yang, C. He, G. Tai, and Y. Zhou. 2018. The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration. International Journal of Biological Macromolecules 106:207–17. doi: https://doi.org/10.1016/j.ijbiomac.2017.08.004.
- Fava, F., and K. M. Tuohy. 2017. Gut microbiota: Inulin regulates endothelial function: A prebiotic smoking gun? Nature Reviews. Gastroenterology & Hepatology 14 (7):392–4. doi: https://doi.org/10.1038/nrgastro.2017.68.
- Fernandes, P. Z., M. Petricevic, L. Sobala, G. J. Davies, and S. J. Williams. 2018. Exploration of strategies for mechanism-based inhibitor design for family GH99 endo-alpha-1,2-mannanases. Chemistry 24 (29):7464–73. doi: https://doi.org/10.1002/chem.201800435.
- Ferreira, S. S., C. P. Passos, P. Madureira, M. Vilanova, and M. A. Coimbra. 2016. Corrigendum to “Structure-function relationships of immunostimulatory polysaccharides: A review” [Carbohydr. Polym. 132 (2015) 378-396]. Carbohydrate Polymers 147:557–8. doi: https://doi.org/10.1016/j.carbpol.2016.04.011.
- Foley, M. H., D. W. Cockburn, and N. M. Koropatkin. 2016. The Sus operon: A model system for starch uptake by the human gut Bacteroidetes. Cellular and Molecular Life Sciences: CMLS 73 (14):2603–17. doi: https://doi.org/10.1007/s00018-016-2242-x.
- Forster, S. C., N. Kumar, B. O. Anonye, A. Almeida, E. Viciani, M. D. Stares, M. Dunn, T. T. Mkandawire, A. Zhu, Y. Shao, et al. 2019. A human gut bacterial genome and culture collection for improved metagenomic analyses. Nature Biotechnology 37 (2):186–92. doi: https://doi.org/10.1038/s41587-018-0009-7.
- Garcia-Bayona, L., and L. E. Comstock. 2019. Streamlined genetic manipulation of diverse bacteroides and parabacteroides isolates from the human gut microbiota. mBio 10 (4):e01762–19. doi: https://doi.org/10.1128/mBio.01762-19.
- Glenwright, A. J., K. R. Pothula, S. P. Bhamidimarri, D. S. Chorev, A. Basle, S. J. Firbank, H. Zheng, C. V. Robinson, M. Winterhalter, U. Kleinekathofer, et al. 2017. Structural basis for nutrient acquisition by dominant members of the human gut microbiota. Nature 541 (7637):407–11. doi: https://doi.org/10.1038/nature20828.
- Groisman, E. A. 2016. Feedback control of two-component regulatory systems. Annual Review of Microbiology 70:103–24. doi: https://doi.org/10.1146/annurev-micro-102215-095331.
- Gudi, R., N. Perez, B. M. Johnson, M. H. Sofi, R. Brown, S. Quan, S. Karumuthil-Melethil, and C. Vasu. 2019. Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes. Immunology 157 (1):70–85. doi: https://doi.org/10.1111/imm.13048.
- Harsha, M. R., S. V. Chandra Prakash, and S. M. Dharmesh. 2016. Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer. Carbohydrate Polymers 138:143–55. doi: https://doi.org/10.1016/j.carbpol.2015.11.043.
- Hehemann, J. H., G. Reintjes, L. Klassen, A. D. Smith, D. Ndeh, C. Arnosti, R. Amann, and D. W. Abbott. 2019. Single cell fluorescence imaging of glycan uptake by intestinal bacteria. The ISME Journal 13 (7):1883–9. doi: https://doi.org/10.1038/s41396-019-0406-z.
- Hemsworth, G. R., G. Dejean, G. J. Davies, and H. Brumer. 2016. Learning from microbial strategies for polysaccharide degradation. Biochemical Society Transactions 44 (1):94–108. doi: https://doi.org/10.1042/BST20150180.
- Hocq, L., J. Pelloux, and V. Lefebvre. 2017. Connecting homogalacturonan-type pectin remodeling to acid growth. Trends in Plant Science 22 (1):20–9. doi: https://doi.org/10.1016/j.tplants.2016.10.009.
- Hu, X., T. Wang, and F. Jin. 2016. Alzheimer’s disease and gut microbiota. Science China. Life Sciences 59 (10):1006–23. doi: https://doi.org/10.1007/s11427-016-5083-9.
- Hu, Y., R. K. Le Leu, C. T. Christophersen, R. Somashekar, M. A. Conlon, X. Q. Meng, J. M. Winter, R. J. Woodman, R. McKinnon, and G. P. Young. 2016. Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats. Carcinogenesis 37 (4):366–75. doi: https://doi.org/10.1093/carcin/bgw019.
- Human Microbiome Project Consortium. 2012. Structure, function and diversity of the healthy human microbiome. Nature 486 (7402):207–14. doi: https://doi.org/10.1038/nature11234.
- Integrative HMP (iHMP) Research Network Consortium. 2019. The Integrative Human Microbiome Project. Nature 569 (7758):641–8. doi: https://doi.org/10.1038/s41586-019-1238-8.
- Jandhyala, S. M., R. Talukdar, C. Subramanyam, H. Vuyyuru, M. Sasikala, and D. Nageshwar Reddy. 2015. Role of the normal gut microbiota. World Journal of Gastroenterology 21 (29):8787–803. doi: https://doi.org/10.3748/wjg.v21.i29.8787.
- Jiao, L., X. Zhang, M. Wang, B. Li, Z. Liu, and S. Liu. 2014. Chemical and antihyperglycemic activity changes of ginseng pectin induced by heat processing. Carbohydrate Polymers 114:567–73. doi: https://doi.org/10.1016/j.carbpol.2014.08.018.
- Jones, L., J. L. Milne, D. Ashford, and S. J. McQueen-Mason. 2003. Cell wall arabinan is essential for guard cell function. Proceedings of the National Academy of Sciences of the United States of America 100 (20):11783–8. doi: https://doi.org/10.1073/pnas.1832434100.
- Kagimura, F. Y., M. A. da Cunha, T. V. Theis, C. R. Malfatti, R. F. Dekker, A. M. Barbosa, S. D. Teixeira, and K. Salome. 2015. Carboxymethylation of (1 → 6)-β-glucan (lasiodiplodan): Preparation, characterization and antioxidant evaluation. Carbohydrate Polymers 127:390–9. doi: https://doi.org/10.1016/j.carbpol.2015.03.045.
- Kloppenburg, M., F. P. Kroon, F. J. Blanco, M. Doherty, K. S. Dziedzic, E. Greibrokk, I. K. Haugen, G. Herrero-Beaumont, H. Jonsson, I. Kjeken, et al. 2019. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Annals of the Rheumatic Diseases 78 (1):16–24. doi: https://doi.org/10.1136/annrheumdis-2018-213826.
- Kolodziejczyk, A. A., D. Zheng, and E. Elinav. 2019. Diet-microbiota interactions and personalized nutrition. Nature Reviews. Microbiology 17 (12):742–53. doi: https://doi.org/10.1038/s41579-019-0256-8.
- Koropatkin, N. M., E. C. Martens, J. I. Gordon, and T. J. Smith. 2008. Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices. Structure (London, England: 1993) 16 (7):1105–15. doi: https://doi.org/10.1016/j.str.2008.03.017.
- La Rosa, S. L., M. L. Leth, L. Michalak, M. E. Hansen, N. A. Pudlo, R. Glowacki, G. Pereira, C. T. Workman, M. O. Arntzen, P. B. Pope, et al. 2019. The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans. Nature Communications 10 (1):905. doi: https://doi.org/10.1038/s41467-019-08812-y.
- Labourel, A., A. Basle, J. Munoz-Munoz, D. Ndeh, S. Booth, S. A. Nepogodiev, R. A. Field, and A. Cartmell. 2019. Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II. The Journal of Biological Chemistry 294 (19):7711–21. doi: https://doi.org/10.1074/jbc.RA118.006626.
- Lammerts van Bueren, A., M. Mulder, S. V. Leeuwen, and L. Dijkhuizen. 2017. Prebiotic galactooligosaccharides activate mucin and pectic galactan utilization pathways in the human gut symbiont Bacteroides thetaiotaomicron. Scientific Reports 7:40478. doi: https://doi.org/10.1038/srep40478.
- Lange, A., S. Beier, A. Steimle, I. B. Autenrieth, D. H. Huson, and J. S. Frick. 2016. Extensive mobilome-driven genome diversification in mouse gut-associated Bacteroides vulgatus mpk. Genome Biology and Evolution 8 (4):1197–207. doi: https://doi.org/10.1093/gbe/evw070.
- Lapebie, P., V. Lombard, E. Drula, N. Terrapon, and B. Henrissat. 2019. Bacteroidetes use thousands of enzyme combinations to break down glycans. Nature Communications 10 (1):2043. doi: https://doi.org/10.1038/s41467-019-10068-5.
- Larsbrink, J., T. E. Rogers, G. R. Hemsworth, L. S. McKee, A. S. Tauzin, O. Spadiut, S. Klinter, N. A. Pudlo, K. Urs, N. M. Koropatkin, et al. 2014. A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes. Nature 506 (7489):498–502. doi: https://doi.org/10.1038/nature12907.
- Leiva-Gea, I., L. Sanchez-Alcoholado, B. Martin-Tejedor, D. Castellano-Castillo, I. Moreno-Indias, A. Urda-Cardona, F. J. Tinahones, J. C. Fernandez-Garcia, and M. I. Queipo-Ortuno. 2018. Gut microbiota differs in composition and functionality between children with type 1 diabetes and MODY2 and healthy control subjects: A case-control study. Diabetes Care 41 (11):2385–95. doi: https://doi.org/10.2337/dc18-0253.
- Leth, M. L., M. Ejby, C. Workman, D. A. Ewald, S. S. Pedersen, C. Sternberg, M. I. Bahl, T. R. Licht, F. L. Aachmann, B. Westereng, et al. 2018. Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut. Nature Microbiology 3 (5):570–80. doi: https://doi.org/10.1038/s41564-018-0132-8.
- Levesque-Tremblay, G., J. Pelloux, S. A. Braybrook, and K. Muller. 2015. Tuning of pectin methylesterification: Consequences for cell wall biomechanics and development. Planta 242 (4):791–811. doi: https://doi.org/10.1007/s00425-015-2358-5.
- Ley, R. E., F. Backhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, and J. I. Gordon. 2005. Obesity alters gut microbial ecology. Proceedings of the National Academy of Sciences of the United States of America 102 (31):11070–5. doi: https://doi.org/10.1073/pnas.0504978102.
- Li, J. P., and M. Kusche-Gullberg. 2016. Heparan sulfate: Biosynthesis, structure, and function. International Review of Cell and Molecular Biology 325:215–73. doi: https://doi.org/10.1016/bs.ircmb.2016.02.009.
- Li, S., J. Li, G. Mao, Y. Hu, X. Ye, D. Tian, R. J. Linhardt, and S. Chen. 2018. Fucosylated chondroitin sulfate oligosaccharides from Isostichopus badionotus regulates lipid disorder in C57BL/6 mice fed a high-fat diet. Carbohydrate Polymers 201:634–42. doi: https://doi.org/10.1016/j.carbpol.2018.08.020.
- Li, S., M. Li, H. Yue, L. Zhou, L. Huang, Z. Du, and K. Ding. 2018. Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains. Carbohydrate Polymers 186:168–75. doi: https://doi.org/10.1016/j.carbpol.2018.01.026.
- Lionetti, V., F. Francocci, S. Ferrari, C. Volpi, D. Bellincampi, R. Galletti, R. D'Ovidio, G. De Lorenzo, and F. Cervone. 2010. Engineering the cell wall by reducing de-methyl-esterified homogalacturonan improves saccharification of plant tissues for bioconversion. Proceedings of the National Academy of Sciences of the United States of America 107 (2):616–21. doi: https://doi.org/10.1073/pnas.0907549107.
- Lionnet, A., L. Leclair-Visonneau, M. Neunlist, S. Murayama, M. Takao, C. H. Adler, P. Derkinderen, and T. G. Beach. 2018. Does Parkinson’s disease start in the gut? Acta Neuropathologica 135 (1):1–12. doi: https://doi.org/10.1007/s00401-017-1777-8.
- Liu, F., N. Zhang, Z. Li, X. Wang, H. Shi, C. Xue, R. W. Li, and Q. Tang. 2017. Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions. Scientific Reports 7 (1):6783. doi: https://doi.org/10.1038/s41598-017-05860-6.
- Liu, H., P. He, L. He, Q. Li, J. Cheng, Y. Wang, G. Yang, and B. Yang. 2018. Structure characterization and hypoglycemic activity of an arabinogalactan from Phyllostachys heterocycla bamboo shoot shell. Carbohydrate Polymers 201:189–200. doi: https://doi.org/10.1016/j.carbpol.2018.08.024.
- Liu, N., H. J. Li, M. G. Chevrette, L. Zhang, L. Cao, H. K. Zhou, X. G. Zhou, Z. H. Zhou, P. B. Pope, C. R. Currie, et al. 2019. Functional metagenomics reveals abundant polysaccharide-degrading gene clusters and cellobiose utilization pathways within gut microbiota of a wood-feeding higher termite. The ISME Journal 13 (1):104–17. doi: https://doi.org/10.1038/s41396-018-0255-1.
- Liu, Y., and G. Huang. 2018. The derivatization and antioxidant activities of yeast mannan. International Journal of Biological Macromolecules 107 (Pt A):755–61. doi: https://doi.org/10.1016/j.ijbiomac.2017.09.055.
- Liu, Y., G. Huang, and M. Lv. 2018. Extraction, characterization and antioxidant activities of mannan from yeast cell wall. International Journal of Biological Macromolecules 118 (Pt A):952–6. doi: https://doi.org/10.1016/j.ijbiomac.2018.06.145.
- Lonetto, M. A., K. L. Brown, K. E. Rudd, and M. J. Buttner. 1994. Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfamily of eubacterial RNA polymerase sigma factors involved in the regulation of extracytoplasmic functions. Proceedings of the National Academy of Sciences of the United States of America 91 (16):7573–7. doi: https://doi.org/10.1073/pnas.91.16.7573.
- Lovegrove, A., C. H. Edwards, I. De Noni, H. Patel, S. N. El, T. Grassby, C. Zielke, M. Ulmius, L. Nilsson, P. J. Butterworth, et al. 2017. Role of polysaccharides in food, digestion, and health. Critical Reviews in Food Science and Nutrition 57 (2):237–53. doi: https://doi.org/10.1080/10408398.2014.939263.
- Lowe, E. C., A. Basle, M. Czjzek, S. J. Firbank, and D. N. Bolam. 2012. A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system. Proceedings of the National Academy of Sciences of the United States of America 109 (19):7298–303. doi: https://doi.org/10.1073/pnas.1200479109.
- Luis, A. S., J. Briggs, X. Zhang, B. Farnell, D. Ndeh, A. Labourel, A. Basle, A. Cartmell, N. Terrapon, K. Stott, et al. 2018. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nature Microbiology 3 (2):210–19. doi: https://doi.org/10.1038/s41564-017-0079-1.
- Lynch, J. B., and E. Y. Hsiao. 2019. Microbiomes as sources of emergent host phenotypes. Science (New York, N.Y.) 365 (6460):1405–8. doi: https://doi.org/10.1126/science.aay0240.
- Maier, T. V., M. Lucio, L. H. Lee, N. C. VerBerkmoes, C. J. Brislawn, J. Bernhardt, R. Lamendella, J. E. McDermott, N. Bergeron, S. S. Heinzmann, et al. 2017. Impact of dietary resistant starch on the human gut microbiome, metaproteome, and metabolome. mBio 8 (5):e01343–17. doi: https://doi.org/10.1128/mBio.01343-17.
- Marcus, D. M. 2018. Chondroitin sulfate for knee osteoarthritis. Annals of the Rheumatic Diseases 77 (6):e27. doi: https://doi.org/10.1136/annrheumdis-2017-211915.
- Martens, E. C., H. C. Chiang, and J. I. Gordon. 2008. Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe 4 (5):447–57. doi: https://doi.org/10.1016/j.chom.2008.09.007.
- Martens, E. C., N. M. Koropatkin, T. J. Smith, and J. I. Gordon. 2009. Complex glycan catabolism by the human gut microbiota: The Bacteroidetes Sus-like paradigm. The Journal of Biological Chemistry 284 (37):24673–7. doi: https://doi.org/10.1074/jbc.R109.022848.
- Martens, E. C., E. C. Lowe, H. Chiang, N. A. Pudlo, M. Wu, N. P. McNulty, D. W. Abbott, B. Henrissat, H. J. Gilbert, D. N. Bolam, et al. 2011. Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts. PLoS Biology 9 (12):e1001221. doi: https://doi.org/10.1371/journal.pbio.1001221.
- Martens, E. C., R. Roth, J. E. Heuser, and J. I. Gordon. 2009. Coordinate regulation of glycan. degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont. The Journal of Biological Chemistry 284 (27):18445–57. doi: https://doi.org/10.1074/jbc.M109.008094.
- Maxwell, E. G., I. J. Colquhoun, H. K. Chau, A. T. Hotchkiss, K. W. Waldron, V. J. Morris, and N. J. Belshaw. 2015. Rhamnogalacturonan I containing homogalacturonan inhibits colon cancer cell proliferation by decreasing ICAM1 expression. Carbohydrate Polymers 132:546–53. doi: https://doi.org/10.1016/j.carbpol.2015.06.082.
- Meenu, M., and B. Xu. 2019. A critical review on anti-diabetic and anti-obesity effects of dietary resistant starch. Critical Reviews in Food Science and Nutrition 59 (18):3019–31. doi: https://doi.org/10.1080/10408398.2018.1481360.
- Meijerink, M., C. Rosch, N. Taverne, K. Venema, H. Gruppen, H. A. Schols, and J. M. Wells. 2018. Structure dependent-immunomodulation by sugar beet arabinans via a SYK tyrosine kinase-dependent signaling pathway. Frontiers in Immunology 9:1972. doi: https://doi.org/10.3389/fimmu.2018.01972.
- Meijnikman, A. S., V. E. Gerdes, M. Nieuwdorp, and H. Herrema. 2018. Evaluating causality of gut microbiota in obesity and diabetes in humans. Endocrine Reviews 39 (2):133–53. doi: https://doi.org/10.1210/er.2017-00192.
- Mende, M., C. Bednarek, M. Wawryszyn, P. Sauter, M. B. Biskup, U. Schepers, and S. Bräse. 2016. Chemical Synthesis of Glycosaminoglycans. Chemical Reviews 116 (14):8193–255. doi:https://doi.org/10.1021/acs.chemrev.6b00010.27410264.
- Methe, B. A., K. E. Nelson, M. Pop, H. H. Creasy, M. G. Giglio, C. Huttenhower, D. Gevers, J. F. Petrosino, S. Abubucker, J. H. Badger, et al. 2012. A framework for human microbiome research. Nature 486 (7402):215–21. doi: https://doi.org/10.1038/nature11209.
- Mimee, M., A. C. Tucker, C. A. Voigt, and T. K. Lu. 2016. Programming a human commensal bacterium, Bacteroides thetaiotaomicron, to sense and respond to stimuli in the murine gut microbiota. Cell Systems 2 (3):214. doi: https://doi.org/10.1016/j.cels.2016.03.007.
- Mohnen, D. 2008. Pectin structure and biosynthesis. Current Opinion in Plant Biology 11 (3):266–77. doi: https://doi.org/10.1016/j.pbi.2008.03.006.
- Mulloy, B., J. Hogwood, E. Gray, R. Lever, and C. P. Page. 2016. Pharmacology of heparin and related drugs. Pharmacological Reviews 68 (1):76–141. doi: https://doi.org/10.1124/pr.115.011247.
- Ndeh, D., and H. J. Gilbert. 2018. Biochemistry of complex glycan depolymerisation by the human. gut microbiota. FEMS Microbiology Reviews 42 (2):146–64. doi: https://doi.org/10.1093/femsre/fuy002.
- Ndeh, D., J. Munoz Munoz, A. Cartmell, D. Bulmer, C. Wills, B. Henrissat, and J. Gray. 2018. The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. The Journal of Biological Chemistry 293 (46):17906–16. doi: https://doi.org/10.1074/jbc.RA118.004510.
- Ndeh, D., A. Rogowski, A. Cartmell, A. S. Luis, A. Basle, J. Gray, I. Venditto, J. Briggs, X. Zhang, A. Labourel, et al. 2017. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature 544 (7648):65–70. doi: https://doi.org/10.1038/nature21725.
- Ndeh, D., A. Basle, H. Strahl, E. A. Yates, U. L. McClurgg, B. Henrissat, N. Terrapon, and A. Cartmell. 2020. Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications 11 (1):646. doi: https://doi.org/10.1038/s41467-020-14509-4.
- Noinaj, N., M. Guillier, T. J. Barnard, and S. K. Buchanan. 2010. TonB-dependent transporters: Regulation, structure, and function. Annual Review of Microbiology 64:43–60. doi: https://doi.org/10.1146/annurev.micro.112408.134247.
- O'Neill, M., P. Albersheim, and A. J. M. i P. B. Darvill. 1990. The pectic polysaccharides of primary cell walls. J Methods in Plant Biochemistry 2:415–41. doi: https://doi.org/10.1016/b978-0-12-461012-5.50018-5.
- O'Neill, M. A., T. Ishii, P. Albersheim, and A. G. Darvill. 2004. Rhamnogalacturonan II: Structure and function of a borate cross-linked cell wall pectic polysaccharide. Annual Review of Plant Biology 55:109–39. doi: https://doi.org/10.1146/annurev.arplant.55.031903.141750.
- Oliphant, K., and E. Allen-Vercoe. 2019. Macronutrient metabolism by the human gut microbiome: Major fermentation by-products and their impact on host health. Microbiome 7 (1):91. doi: https://doi.org/10.1186/s40168-019-0704-8.
- Oliveira, A. F., G. E. D. Nascimento, M. Iacomini, L. M. C. Cordeiro, and T. R. Cipriani. 2017. Chemical structure and anti-inflammatory effect of polysaccharides obtained from infusion of Sedum dendroideum leaves. International Journal of Biological Macromolecules 105 (Pt 1):940–6. doi: https://doi.org/10.1016/j.ijbiomac.2017.07.122.
- Ortiz-Soto, M. E., J. R. Porras-Dominguez, J. Seibel, and A. Lopez-Munguia. 2019. A close look at the structural features and reaction conditions that modulate the synthesis of low and high molecular weight fructans by levansucrases. Carbohydrate Polymers 219 (1):130–42. doi: https://doi.org/10.1016/j.carbpol.2019.05.014.
- Panebianco, C., A. Andriulli, and V. Pazienza. 2018. Pharmacomicrobiomics: Exploiting the drug-microbiota interactions in anticancer therapies. Microbiome 6 (1):92. doi: https://doi.org/10.1186/s40168-018-0483-7.
- Park, H. R., D. Hwang, H. J. Suh, K. W. Yu, T. Y. Kim, and K. S. Shin. 2017. Antitumor and antimetastatic activities of rhamnogalacturonan-II-type polysaccharide isolated from mature leaves of green tea via activation of macrophages and natural killer cells. International Journal of Biological Macromolecules 99:179–86. doi: https://doi.org/10.1016/j.ijbiomac.2017.02.043.
- Park, H. R., S. B. Park, H. D. Hong, H. J. Suh, and K. S. Shin. 2017. Structural elucidation of anti-metastatic rhamnogalacturonan II from the pectinase digest of citrus peels (Citrus unshiu). International Journal of Biological Macromolecules 94:161–9. doi: https://doi.org/10.1016/j.ijbiomac.2016.09.100.
- Pasolli, E., F. Asnicar, S. Manara, M. Zolfo, N. Karcher, F. Armanini, F. Beghini, P. Manghi, A. Tett, P. Ghensi, et al. 2019. Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle. Cell 176 (3):649–62. doi: https://doi.org/10.1016/j.cell.2019.01.001.
- Pellegrini, C., L. Antonioli, R. Colucci, C. Blandizzi, and M. Fornai. 2018. Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: A common path to neurodegenerative diseases? Acta Neuropathologica 136 (3):345–61. doi: https://doi.org/10.1007/s00401-018-1856-5.
- Porter, N. T., A. S. Luis, and E. C. Martens. 2018. Bacteroides thetaiotaomicron. Trends in Microbiology 26 (11):966–7. doi: https://doi.org/10.1016/j.tim.2018.08.005.
- Porter, N. T., and E. C. Martens. 2017. The critical roles of polysaccharides in gut microbial ecology and physiology. Annual Review of Microbiology 71:349–69. doi: https://doi.org/10.1146/annurev-micro-102215-095316.
- Qian, X., L. Chen, Y. Sui, C. Chen, W. Zhang, J. Zhou, W. Dong, M. Jiang, F. Xin, and K. Ochsenreither. 2020. Biotechnological potential and applications of microbial consortia. Biotechnology Advances 40:107500. doi: https://doi.org/10.1016/j.biotechadv.2019.107500.
- Raghavan, V., E. C. Lowe, G. E. Townsend, D. N. Bolam, and E. A. Groisman. 2014. Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium. Molecular Microbiology 93 (5):1010–25. doi: https://doi.org/10.1111/mmi.12714.
- Rakoff-Nahoum, S., K. R. Foster, and L. E. Comstock. 2016. The evolution of cooperation within the gut microbiota. Nature 533 (7602):255–9. doi: https://doi.org/10.1038/nature17626.
- Ravcheev, D. A., A. Godzik, A. L. Osterman, and D. A. Rodionov. 2013. Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: Comparative genomics reconstruction of metabolic and regulatory networks. BMC Genomics 14:873. doi: https://doi.org/10.1186/1471-2164-14-873.
- Ridley, B. L., M. A. O'Neill, and D. Mohnen. 2001. Pectins: Structure, biosynthesis, and oligogalacturonide-related signaling. Phytochemistry 57 (6):929–67. doi: https://doi.org/10.1016/S0031-9422(01)00113-3.
- Rogers, T. E., N. A. Pudlo, N. M. Koropatkin, J. S. Bell, M. M. Balasch, K. Jasker, and E. C. Martens. 2013. Dynamic responses of Bacteroides thetaiotaomicron during growth on glycan mixtures. Molecular Microbiology 88 (5):876–90. doi: https://doi.org/10.1111/mmi.12228.
- Rogowski, A., J. A. Briggs, J. C. Mortimer, T. Tryfona, N. Terrapon, E. C. Lowe, A. Baslé, C. Morland, A. M. Day, H. Zheng, et al. 2015. Glycan complexity dictates microbial resource allocation in the large intestine. Nature Communications 6:7481. doi: https://doi.org/10.1038/ncomms8481.
- Ryttersgaard, C., J. L. Nours, L. Lo Leggio, C. T. Jorgensen, L. L. Christensen, M. Bjornvad, and S. Larsen. 2004. The structure of endo-beta-1,4-galactanase from Bacillus licheniformis in complex with two oligosaccharide products. Journal of Molecular Biology 341 (1):107–17. doi: https://doi.org/10.1016/j.jmb.2004.05.017.
- Schirmer, M., A. Garner, H. Vlamakis, and R. J. Xavier. 2019. Microbial genes and pathways in inflammatory bowel disease. Nature Reviews. Microbiology 17 (8):497–511. doi: https://doi.org/10.1038/s41579-019-0213-6.
- Schwalm, N. D., III, and E. A. Groisman. 2017. Navigating the gut buffet: Control of polysaccharide utilization in Bacteroides spp. Trends in Microbiology 25 (12):1005–15. doi: https://doi.org/10.1016/j.tim.2017.06.009.
- Schwalm, N. D., III, G. E. Townsend, II, and E. A. Groisman. 2016. Multiple signals govern utilization of a polysaccharide in the gut bacterium Bacteroides thetaiotaomicron. mBio 7 (5):e01342–16. doi: https://doi.org/10.1128/mBio.01342-16.
- Schwalm, N. D., III, G. E. Townsend, II, and E. A. Groisman. 2017. Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron. Molecular Microbiology 104 (1):32–45. doi: https://doi.org/10.1111/mmi.13609.
- Shang, Q., J. Shi, G. Song, M. Zhang, C. Cai, J. Hao, G. Li, and G. Yu. 2016. Structural modulation of gut microbiota by chondroitin sulfate and its oligosaccharide. International Journal of Biological Macromolecules 89:489–98. doi: https://doi.org/10.1016/j.ijbiomac.2016.04.091.
- Shipman, J. A., K. H. Cho, H. A. Siegel, and A. A. Salyers. 1999. Physiological characterization of SusG, an outer membrane protein essential for starch utilization by Bacteroides thetaiotaomicron. Journal of Bacteriology 181 (23):7206–11. doi: https://doi.org/10.1128/JB.181.23.7206-7211.1999.
- Singh, S., G. Singh, and S. K. Arya. 2018. Mannans: An overview of properties and application in food products. International Journal of Biological Macromolecules 119:79–95. doi: https://doi.org/10.1016/j.ijbiomac.2018.07.130.
- Sonnenburg, E. D., H. Zheng, P. Joglekar, S. K. Higginbottom, S. J. Firbank, D. N. Bolam, and J. L. Sonnenburg. 2010. Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations. Cell 141 (7):1241–52. doi: https://doi.org/10.1016/j.cell.2010.05.005.
- Tabachnikov, O., and Y. Shoham. 2013. Functional characterization of the galactan utilization system of Geobacillus stearothermophilus. The FEBS Journal 280 (3):950–64. doi: https://doi.org/10.1111/febs.12089.
- Tang, S., M. Y. Jiang, C. X. Huang, C. H. Lai, Y. M. Fan, and Q. Yong. 2018. Characterization of arabinogalactans from Larix principis-rupprechtii and their effects on NO production by macrophages. Carbohydrate Polymers 200:408–15. doi: https://doi.org/10.1016/j.carbpol.2018.08.027.
- Tang, W. H. W., D. Y. Li, and S. L. Hazen. 2019. Dietary metabolism, the gut microbiome, and heart failure. Nature Reviews. Cardiology 16 (3):137–54. doi: https://doi.org/10.1038/s41569-018-0108-7.
- Temple, M. J., F. Cuskin, A. Basle, N. Hickey, G. Speciale, S. J. Williams, H. J. Gilbert, and E. C. Lowe. 2017. A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: Unique substrate conformation drives specificity of the key endo-1,6-β-glucanase. The Journal of Biological Chemistry 292 (25):10639–50. doi: https://doi.org/10.1074/jbc.M117.787606.
- Terrapon, N., V. Lombard, H. J. Gilbert, and B. Henrissat. 2015. Automatic prediction of polysaccharide utilization loci in Bacteroidetes species. Bioinformatics (Oxford, England) 31 (5):647–55. doi: https://doi.org/10.1093/bioinformatics/btu716.
- Townsend, G. E., II, W. Han, N. D. Schwalm, III, V. Raghavan, N. A. Barry, A. L. Goodman, and E. A. Groisman. 2019. Dietary sugar silences a colonization factor in a mammalian gut symbiont. Proceedings of the National Academy of Sciences of the United States of America 116 (1):233–8. doi: https://doi.org/10.1073/pnas.1813780115.
- Turnbaugh, P. J., M. Hamady, T. Yatsunenko, B. L. Cantarel, A. Duncan, R. E. Ley, M. L. Sogin, W. J. Jones, B. A. Roe, J. P. Affourtit, et al. 2009. A core gut microbiome in obese and lean twins. Nature 457 (7228):480–4. doi: https://doi.org/10.1038/nature07540.
- Turnbaugh, P. J., R. E. Ley, M. Hamady, C. M. Fraser-Liggett, R. Knight, and J. I. Gordon. 2007. The human microbiome project. Nature 449 (7164):804–10. doi: https://doi.org/10.1038/nature06244.
- Ulmer, J. E., E. M. Vilen, R. B. Namburi, A. Benjdia, J. Beneteau, A. Malleron, D. Bonnaffe, P. A. Driguez, K. Descroix, G. Lassalle, et al. 2014. Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. The Journal of Biological Chemistry 289 (35):24289–303. doi: https://doi.org/10.1074/jbc.M114.573303.
- Vaughn, B. P., K. M. Rank, and A. Khoruts. 2019. Fecal microbiota transplantation: Current status in treatment of GI and liver disease. Clinical Gastroenterology and Hepatology 17 (2):353–61. doi: https://doi.org/10.1016/j.cgh.2018.07.026.
- Venkataraman, A., J. R. Sieber, A. W. Schmidt, C. Waldron, K. R. Theis, and T. M. Schmidt. 2016. Variable responses of human microbiomes to dietary supplementation with resistant starch. Microbiome 4 (1):33. doi: https://doi.org/10.1186/s40168-016-0178-x.
- Voragen, A. G. J., G. J. Coenen, R. P. Verhoef, and H. A. Schols. 2009. Pectin, a versatile polysaccharide present in plant cell walls. Structural Chemistry 20 (2):263–75. doi: https://doi.org/10.1007/s11224-009-9442-z.
- Wang, D., T. H. Yeats, S. Uluisik, J. K. C. Rose, and G. B. Seymour. 2018. Fruit softening: Revisiting the role of pectin. Trends Plant Sci 23 (4):302–10. doi: https://doi.org/10.1016/j.tplants.2018.01.006.
- Wang, H., T. Gao, Y. Du, H. Yang, L. Wei, H. Bi, and W. Ni. 2015. Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry. Carbohydrate Polymers 131:288–96. doi: https://doi.org/10.1016/j.carbpol.2015.06.021.
- Wang, H., S. Shi, B. Bao, X. Li, and S. Wang. 2015. Structure characterization of an arabinogalactan from green tea and its anti-diabetic effect. Carbohydrate Polymers 124:98–108. doi: https://doi.org/10.1016/j.carbpol.2015.01.070.
- Wang, H. L., H. T. Bi, T. T. Gao, B. Zhao, W. H. Ni, and J. Liu. 2018. A homogalacturonan from Hippophae rhamnoides L. Berries enhance immunomodulatory activity through TLR4/MyD88 pathway mediated activation of macrophages. International Journal of Biological Macromolecules 107 (Pt A):1039–45. doi: https://doi.org/10.1016/j.ijbiomac.2017.09.083.
- Wang, P., L. Zhang, J. Yao, Y. Shi, P. Li, and K. Ding. 2015. An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling. Carbohydrate Polymers 121:328–35. doi: https://doi.org/10.1016/j.carbpol.2014.11.073.
- Wang, X., G. Sun, T. Feng, J. Zhang, X. Huang, T. Wang, Z. Xie, X. Chu, J. Yang, H. Wang, et al. 2019. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. Cell Research 29 (10):787–803. doi: https://doi.org/10.1038/s41422-019-0216-x.
- Wang, X. X., Q. Pan, F. Ma, P. J. Li, B. C. Xu, and C. G. Chen. 2019. Amelioration of growth, performance, lipid accumulation, and intestinal health in mice by a cooked mixture of lean meat and resistant starch. Molecular Nutrition & Food Research 63 (10):e1801364. doi: https://doi.org/10.1002/mnfr.201801364.
- Wefers, D., R. Florchinger, and M. Bunzel. 2018. Detailed structural characterization of arabinans and galactans of 14 apple cultivars before and after cold storage. Frontiers in Plant Science 9:1451. doi: https://doi.org/10.3389/fpls.2018.01451.
- Wefers, D., C. E. Tyl, and M. Bunzel. 2014. Novel arabinan and galactan oligosaccharides from dicotyledonous plants. Frontiers in Chemistry 2:100. doi: https://doi.org/10.3389/fchem.2014.00100.
- Wexler, A. G., and A. L. Goodman. 2017. An insider’s perspective: Bacteroides as a window into the microbiome. Nature Microbiology 2 (5):17026. doi: https://doi.org/10.1038/nmicrobiol.2017.26.
- Wiener, M. C. 2005. TonB-dependent outer membrane transport: Going for baroque? Current Opinion in Structural Biology 15 (4):394–400. doi: https://doi.org/10.1016/j.sbi.2005.07.001.
- Wu, D. M., J. Q. Zheng, G. Z. Mao, W. W. Hu, X. Q. Ye, R. J. Linhardt, and S. G. Chen. 2019. Rethinking the impact of RG-I mainly from fruits and vegetables on dietary health. Critical Reviews in Food Science and Nutrition 14:1–23. doi: https://doi.org/10.1080/10408398.2019.1672037.
- Xu, J., M. K. Bjursell, J. Himrod, S. Deng, L. K. Carmichael, H. C. Chiang, L. V. Hooper, and J. I. Gordon. 2003. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science (New York, N.Y.) 299 (5615):2074–6. doi: https://doi.org/10.1126/science.1080029.
- Xu, W., D. Ni, W. Zhang, C. Guang, T. Zhang, and W. Mu. 2019. Recent advances in Levansucrase and Inulosucrase: Evolution, characteristics, and application. Critical Reviews in Food Science and Nutrition 59 (22):3630–47. doi: https://doi.org/10.1080/10408398.2018.1506421.
- Yao, Y., J. Yao, Z. Du, P. Wang, and K. Ding. 2018. Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L. Carbohydrate Polymers 202:134–42. doi: https://doi.org/10.1016/j.carbpol.2018.08.098.
- Yu, Y., C. Patch, K. Weston-Green, Y. Zhou, K. Zheng, and X. F. Huang. 2018. Dietary galacto-oligosaccharides and resistant starch protect against altered CB1 and 5-HT1A and 2A receptor densities in rat brain: Implications for preventing cognitive and appetite dysfunction during a high-fat diet. Molecular Nutrition & Food Research 62 (21):e1800422. doi: https://doi.org/10.1002/mnfr.201800422.
- Zaman, S. A., and S. R. Sarbini. 2016. The potential of resistant starch as a prebiotic. Critical Reviews in Biotechnology 36 (3):578–84. doi: https://doi.org/10.3109/07388551.2014.993590.
- Zhang, F., C. Sodroski, H. Cha, Q. Li, and T. J. Liang. 2017. Infection of hepatocytes with HCV increases cell surface levels of heparan sulfate proteoglycans, uptake of cholesterol and lipoprotein, and virus entry by up-regulating SMAD6 and SMAD7. Gastroenterology 152 (1):257–70. doi: https://doi.org/10.1053/j.gastro.2016.09.033.
- Zhang, H., J. Zhong, Q. Zhang, D. Qing, and C. Yan. 2019. Structural elucidation and bioactivities of a novel arabinogalactan from Coreopsis tinctoria. Carbohydrate Polymers 219:219–28. doi: https://doi.org/10.1016/j.carbpol.2019.05.019.
- Zhang, W., W. Xu, D. Ni, Q. Dai, C. Guang, T. Zhang, and W. Mu. 2019. An overview of levan-degrading enzyme from microbes. Applied Microbiology and Biotechnology 103 (19):7891–902. doi: https://doi.org/10.1007/s00253-019-10037-4.
- Zhang, Z., Q. Liu, and W. A. Hendrickson. 2014. Crystal structures of apparent saccharide sensors from histidine kinase receptors prevalent in a human gut symbiont. The FEBS Journal 281 (18):4263–79. doi: https://doi.org/10.1111/febs.12904.
- Zheng, H., J. Perreau, J. E. Powell, B. Han, Z. Zhang, W. K. Kwong, S. G. Tringe, and N. A. Moran. 2019. Division of labor in honey bee gut microbiota for plant polysaccharide digestion. Proceedings of the National Academy of Sciences of the United States of America 116 (51):25909–16. doi: https://doi.org/10.1073/pnas.1916224116.
- Zheng, J., H. Li, X. Zhang, M. Jiang, C. Luo, Z. Lu, Z. Xu, and J. Shi. 2018. Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of metformin in correlation with modulating gut microbiota. Journal of Agricultural and Food Chemistry 66 (23):5821–31. doi: https://doi.org/10.1021/acs.jafc.8b00829.
- Zhou, L., W. Liao, X. Chen, H. Yue, S. Li, and K. Ding. 2018. An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of Aβ42. Carbohydrate Polymers 195:643–51. doi: https://doi.org/10.1016/j.carbpol.2018.05.022.