628
Views
8
CrossRef citations to date
0
Altmetric
Reviews

Amorphous systems for delivery of nutraceuticals: challenges opportunities

, ORCID Icon, , , , , , & show all

References

  • Ahmadi, Z., R. Mohammadinejad, and M. Ashrafizadeh. 2019. Drug delivery systems for resveratrol, a non-flavonoid polyphenol: Emerging evidence in last decades. Journal of Drug Delivery Science and Technology 51:591–604. doi: 10.1016/j.jddst.2019.03.017.
  • Alhayali, A., S. Tavellin, and S. Velaga. 2017. Dissolution and precipitation behavior of ternary solid dispersions of ezetimibe in biorelevant media. Drug Development and Industrial Pharmacy 43 (1):79–88. doi: 10.1080/03639045.2016.1220566.
  • Alshehri, S., S. S. Imam, M. A. Altamimi, A. Hussain, F. Shakeel, E. Elzayat, K. Mohsin, M. Ibrahim, and F. Alanazi. 2020. Enhanced dissolution of luteolin by solid dispersion prepared by different methods: Physicochemical characterization and antioxidant activity. ACS Omega 5 (12):6461–71. doi: 10.1021/acsomega.9b04075.
  • Alshehri, S. M., F. Shakeel, M. A. Ibrahim, E. M. Elzayat, M. Altamimi, K. Mohsin, O. T. Almeanazel, M. Alkholief, A. Alshetaili, B. Alsulays, et al. 2019. Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques. Saudi Pharmaceutical Journal: SPJ: The Official Publication of the Saudi Pharmaceutical Society 27 (2):264–73. doi: 10.1016/j.jsps.2018.11.008.
  • Altamimi, M. A., E. M. Elzayat, S. M. Alshehri, K. Mohsin, M. A. Ibrahim, O. T. Al Meanazel, F. Shakeel, F. K. Alanazi, and I. A. Alsarra. 2018. Utilizing spray drying technique to improve oral bioavailability of apigenin. Advanced Powder Technology 29 (7):1676–84. doi: 10.1016/j.apt.2018.04.002.
  • Amidon, G. L., H. Lennernã¤S, V. P. Shah, and J. R. Crison. 1995. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research 12 (3):413–20. doi: 10.1023/A:1016212804288.
  • Ashour, E. A., S. Majumdar, A. Alsheteli, S. Alshehri, B. Alsulays, X. Feng, A. Gryczke, K. Kolter, N. Langley, and M. A. Repka. 2016. Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine. The Journal of Pharmacy and Pharmacology 68 (8):989–98. doi: 10.1111/jphp.12579.
  • Bellik, Y., L. D. Boukraã¢, H. A. Alzahrani, B. A. Bakhotmah, F. Abdellah, S. M. Hammoudi, and M. Iguer-Ouada. 2012. Molecular mechanism underlying anti-inflammatory and anti-allergic activities of phytochemicals: An update. Molecules (Basel, Switzerland) 18 (1):322–53. doi: 10.3390/molecules18010322.
  • Bowers, J. L., V. V. Tyulmenkov, S. C. Jernigan, and C. M. Klinge. 2000. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 141 (10):3657–67. doi: 10.1210/endo.141.10.7721.
  • Buckton, G., and H. Gill. 2007. The importance of surface energetics of powders for drug delivery and the establishment of inverse gas chromatography. Advanced Drug Delivery Reviews 59 (14):1474–9. doi: 10.1016/j.addr.2007.06.017.
  • Calvani, M., A. Pasha, and C. Favre. 2020. Nutraceutical boom in cancer: Inside the labyrinth of reactive oxygen species. International Journal of Molecular Sciences 21 (6):1936. doi: 10.3390/ijms21061936.
  • Cao, Y., J. Teng, and J. Selbo. 2017. Amorphous solid dispersion of epigallocatechin gallate for enhanced physical stability and controlled release. Pharmaceuticals 10 (4):88. doi: 10.3390/ph10040088.
  • Chieng, N., J. Aaltonen, D. Saville, and T. Rades. 2009. Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V 71 (1):47–54. doi: 10.1016/j.ejpb.2008.06.022.
  • Chuah, A. M., B. Jacob, Z. Jie, S. Ramesh, S. Mandal, J. K. Puthan, P. Deshpande, V. V. Vaidyanathan, R. W. Gelling, G. Patel, et al. 2014. Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin. Food Chemistry 156:227–33. doi: 10.1016/j.foodchem.2014.01.108.
  • Colombo, M., G. DE Lima Melchiades, L. R. Michels, F. Figueiró, V. L. Bassani, H. F. Teixeira, and L. S. Koester. 2019. Solid dispersion of kaempferol: Formulation development, characterization, and oral bioavailability assessment. AAPS PharmSciTech 20 (3):106. doi: 10.1208/s12249-019-1318-y.
  • Cui, L., J. Miao, and L. Cui. 2007. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: Inhibition of histone acetylation and generation of reactive oxygen species. Antimicrobial Agents and Chemotherapy 51 (2):488–94. doi: 10.1128/AAC.01238-06.
  • Dahlberg, C., A. Millqvist-Fureby, M. Schuleit, and I. Furó. 2010. Relationships between solid dispersion preparation process, particle size and drug release–an NMR and NMR microimaging study. European Journal of Pharmaceutics and Biopharmaceutics 76 (2):311–9. doi: 10.1016/j.ejpb.2010.06.006.
  • Dengale, S. J., H. Grohganz, T. Rades, and K. Löbmann. 2016. Recent advances in co-amorphous drug formulations. Advanced Drug Delivery Reviews 100:116–25. doi: 10.1016/j.addr.2015.12.009.
  • Dengale, S. J., S. S. Hussen, B. S. M. Krishna, P. B. Musmade, G. G. Shenoy, and K. Bhat. 2015. Fabrication, solid state characterization and bioavailability assessment of stable binary amorphous phases of Ritonavir with Quercetin. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V 89:329–38. doi: 10.1016/j.ejpb.2014.12.025.
  • Dima, C., E. Assadpour, S. Dima, and S. M. Jafari. 2020. Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems. Comprehensive Reviews in Food Science and Food Safety 33:1–41.
  • Dokoumetzidis, A., and P. Macheras. 2006. A century of dissolution research: From Noyes and Whitney to the biopharmaceutics classification system. International Journal of Pharmaceutics 321 (1–2):1–11. doi: 10.1016/j.ijpharm.2006.07.011.
  • Fael, H., and A. L. Demirel. 2020. Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior. International Journal of Pharmaceutics 581:119284. doi: 10.1016/j.ijpharm.2020.119284.
  • Fan, N., Z. He, P. Ma, X. Wang, C. Li, J. Sun, Y. Sun, and J. Li. 2018a. Impact of HPMC on inhibiting crystallization and improving permeability of curcumin amorphous solid dispersions. Carbohydrate Polymers 181:543–50. doi: 10.1016/j.carbpol.2017.12.004.
  • Fan, N., P. Ma, X. Wang, C. Li, X. Zhang, K. Zhang, J. Li, and Z. He. 2018b. Storage stability and solubilization ability of HPMC in curcumin amorphous solid dispersions formulated by Eudragit E100. Carbohydrate Polymers 199:492–8. doi: 10.1016/j.carbpol.2018.07.036.
  • Fan, W., W. Zhu, X. Zhang, and L. DI. 2020. The preparation of curcumin sustained-release solid dispersion by hot melt extrusion-I. Optimization of the formulation. Journal of Pharmaceutical Sciences 109 (3):1242–52. doi: 10.1016/j.xphs.2019.11.019.
  • Fatima, N., R. M. Hafizur, A. Hameed, S. Ahmed, M. Nisar, and N. Kabir. 2017. Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas. European Journal of Nutrition 56 (2):591–601. doi: 10.1007/s00394-015-1103-y.
  • Ford, J. L., and M. H. Rubinstein. 1981. Preparation, properties and ageing of tablets prepared from the chlorpropamide-urea solid dispersion. International Journal of Pharmaceutics 8 (4):311–22. doi: 10.1016/0378-5173(81)90071-5.
  • Gala, U., D. Miller, and R. O. Williams. 2020. Improved dissolution and pharmacokinetics of abiraterone through KinetiSol® enabled amorphous solid dispersions. Pharmaceutics 12 (4):357. doi: 10.3390/pharmaceutics12040357.
  • Gangurde, A. B., H. S. Kundaikar, S. D. Javeer, D. R. Jaiswar, M. S. Degani, and P. D. Amin. 2015. Enhanced solubility and dissolution of curcumin by a hydrophilic polymer solid dispersion and its insilico molecular modeling studies. Journal of Drug Delivery Science and Technology 29:226–37. doi: 10.1016/j.jddst.2015.08.005.
  • Gilley, A. D., H. C. Arca, B. L. B. Nichols, L. I. Mosquera-Giraldo, L. S. Taylor, K. J. Edgar, and A. P. Neilson. 2017. Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro. Carbohydrate Polymers 157:86–93. doi: 10.1016/j.carbpol.2016.09.067.
  • Griffin, B. T., J. Guo, E. Presas, M. D. Donovan, M. J. Alonso, and C. M. O'Driscoll. 2016. Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs. Advanced Drug Delivery Reviews 106 (Pt B):367–80. doi: 10.1016/j.addr.2016.06.006.
  • Grohganz, H., K. Löbmann, P. Priemel, K. T. Jensen, K. Graeser, C. Strachan, and T. Rades. 2013. Amorphous drugs and dosage forms. Journal of Drug Delivery Science and Technology 23 (4):403–8. doi: 10.1016/S1773-2247(13)50057-8.
  • Guo, S., G. Wang, T. Wu, F. Bai, J. Xu, and X. Zhang. 2017. Solid dispersion of berberine hydrochloride and Eudragit® S100: Formulation, physicochemical characterization and cytotoxicity evaluation. Journal of Drug Delivery Science and Technology 40:21–7. doi: 10.1016/j.jddst.2017.02.003.
  • Guo, Y., E. Shalaev, and S. Smith. 2013. Physical stability of pharmaceutical formulations: Solid-state characterization of amorphous dispersions. TrAC Trends in Analytical Chemistry 49:137–44. doi: 10.1016/j.trac.2013.06.002.
  • Han, H. K., B. J. Lee, and H. K. Lee. 2011. Enhanced dissolution and bioavailability of biochanin A via the preparation of solid dispersion: In vitro and in vivo evaluation. International Journal of Pharmaceutics 415:89–94.
  • Han, Y., Y. Pan, J. Lv, W. Guo, and J. Wang. 2016. Powder grinding preparation of co-amorphous β-azelnidipine and maleic acid combination: Molecular interactions and physicochemical properties. Powder Technology 291:110–20. doi: 10.1016/j.powtec.2015.11.068.
  • Hancock, B. C., and G. Zografi. 1997. Characteristics and significance of the amorphous state in pharmaceutical systems. Journal of Pharmaceutical Sciences 86 (1):1–12. doi: 10.1021/js9601896.
  • He, H., Q. Zhang, J. R. Wang, and X. Mei. 2017. Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals. CrystEngComm 19:6154–63.
  • Huang, R., J. Han, R. Wang, X. Zhao, H. Qiao, L. Chen, W. Li, L. Di, W. Zhang, and J. Li. 2019. Surfactant-free solid dispersion of BCS class IV drug in an amorphous chitosan oligosaccharide matrix for concomitant dissolution in vitro-permeability increase. European Journal of Pharmaceutical Sciences 130:147–55. doi: 10.1016/j.ejps.2019.01.031.
  • Ishimoto, K., S. Miki, A. Ohno, Y. Nakamura, S. Otani, M. Nakamura, and S. Nakagawa. 2019. β-Carotene solid dispersion prepared by hot-melt technology improves its solubility in water. Journal of Food Science and Technology 56 (7):3540–6. doi: 10.1007/s13197-019-03793-8.
  • Jensen, K. T., K. Löbmann, T. Rades, and H. Grohganz. 2014. Improving co-amorphous drug formulations by the addition of the highly water soluble amino Acid, proline. Pharmaceutics 6 (3):416–35. doi: 10.3390/pharmaceutics6030416.
  • Jermain, S. V., C. Brough, and R. O. Williams. 2018. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery - An update. International Journal of Pharmaceutics 535 (1–2):379–92. doi: 10.1016/j.ijpharm.2017.10.051.
  • Jha, D. K., D. S. Shah, and P. D. Amin. 2020. Thermodynamic aspects of the preparation of amorphous solid dispersions of naringenin with enhanced dissolution rate. International Journal of Pharmaceutics 583:119363. doi: 10.1016/j.ijpharm.2020.119363.
  • Joshi, H. N., R. W. Tejwani, M. Davidovich, V. P. Sahasrabudhe, M. Jemal, M. S. Bathala, S. A. Varia, and A. T. M. Serajuddin. 2004. Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol–polysorbate 80 mixture. International Journal of Pharmaceutics 269 (1):251–8. doi: 10.1016/j.ijpharm.2003.09.002.
  • Kadota, K., D. Okamoto, H. Sato, S. Onoue, S. Otsu, and Y. Tozuka. 2016. Hybridization of polyvinylpyrrolidone to a binary composite of curcumin/α-glucosyl stevia improves both oral absorption and photochemical stability of curcumin. Food Chemistry 213:668–74. doi: 10.1016/j.foodchem.2016.07.025.
  • Kakran, M., N. G. Sahoo, and L. Li. 2011. Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion. Colloids and Surfaces. B, Biointerfaces 88 (1):121–30. doi: 10.1016/j.colsurfb.2011.06.020.
  • Kanaze, F. I., E. Kokkalou, I. Niopas, P. Barmpalexis, E. Georgarakis, and D. Bikiaris. 2010. Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions. Drug Development and Industrial Pharmacy 36 (3):292–301. doi: 10.1080/03639040903140589.
  • Kanaze, F. I., E. Kokkalou, I. Niopas, M. Georgarakis, A. Stergiou, and D. Bikiaris. 2006. Dissolution enhancement of flavonoids by solid dispersion in PVP and PEG matrixes: A comparative study. Journal of Applied Polymer Science 102 (1):460–71. doi: 10.1002/app.24200.
  • Karagianni, A., K. Kachrimanis, and I. Nikolakakis. 2018. Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery. Pharmaceutics 10 (3):98. doi: 10.3390/pharmaceutics10030098.
  • Ke, P., S. Hasegawa, H. Al-Obaidi, and G. Buckton. 2012. Investigation of preparation methods on surface/bulk structural relaxation and glass fragility of amorphous solid dispersions. International Journal of Pharmaceutics 422 (1–2):170–8. doi: 10.1016/j.ijpharm.2011.10.047.
  • Kerdsakundee, N., S. Mahattanadul, and R. Wiwattanapatapee. 2015. Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions for gastric ulcer treatment. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V 94:513–20. doi: 10.1016/j.ejpb.2015.06.024.
  • Khan, A. W., S. Kotta, S. H. Ansari, R. K. Sharma, and J. Ali. 2015. Enhanced dissolution and bioavailability of grapefruit flavonoid Naringenin by solid dispersion utilizing fourth generation carrier. Drug Development and Industrial Pharmacy 41 (5):772–9. doi: 10.3109/03639045.2014.902466.
  • Kulkarni, C., A. L. Kelly, T. Gough, V. Jadhav, K. K. Singh, and A. Paradkar. 2018. Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug. Drug Development and Industrial Pharmacy 44 (2):206–14. doi: 10.1080/03639045.2017.1386200.
  • Laitinen, R., P. A. Priemel, S. Surwase, K. Graeser, C. J. Strachan, H. Grohganz, and T. Rades. 2014. Theoretical considerations in developing amorphous solid dispersions. In Amorphous solid dispersions. New York, NY: Springer.
  • Laparra, J. M., and Y. Sanz. 2010. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacological Research 61 (3):219–25. doi: 10.1016/j.phrs.2009.11.001.
  • Lee, I. W., J. Li, X. Chen, and H. J. Park. 2017. Fabrication of electrospun antioxidant nanofibers by rutin-pluronic solid dispersions for enhanced solubility. Journal of Applied Polymer Science 134 (21):448–59. doi: 10.1002/app.44859.
  • Letchmanan, K., S.-C. Shen, W. K. Ng, and R. B. H. Tan. 2018. Application of transglycosylated stevia and hesperidin as drug carriers to enhance biopharmaceutical properties of poorly-soluble artemisinin. Colloids and Surfaces B: Biointerfaces 161:83–93. doi: 10.1016/j.colsurfb.2017.10.020.
  • Li, B., M. Wen, W. Li, M. He, X. Yang, and S. Li. 2011. Preparation and characterization of baicalin-poly -vinylpyrrolidone coprecipitate. International Journal of Pharmaceutics 408 (1–2):91–6. doi: 10.1016/j.ijpharm.2011.01.055.
  • Li, B., K. Harich, L. Wegiel, L. S. Taylor, and K. J. Edgar. 2013a. Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions. Carbohydrate Polymers 92 (2):1443–50. doi: 10.1016/j.carbpol.2012.10.051.
  • Li, B., S. Konecke, K. Harich, L. Wegiel, L. S. Taylor, and K. J. Edgar. 2013b. Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability. Carbohydrate Polymers 92 (2):2033–40. doi: 10.1016/j.carbpol.2012.11.073.
  • Li, B., S. Konecke, L. A. Wegiel, L. S. Taylor, and K. J. Edgar. 2013c. Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices. Carbohydrate Polymers 98 (1):1108–16. doi: 10.1016/j.carbpol.2013.07.017.
  • Li, B., H. Liu, M. Amin, L. A. Wegiel, L. S. Taylor, and K. J. Edgar. 2013d. Enhancement of naringenin solution concentration by solid dispersion in cellulose derivative matrices. Cellulose 20 (4):2137–49. doi: 10.1007/s10570-013-9970-y.
  • Li, B., L. A. Wegiel, L. S. Taylor, and K. J. Edgar. 2013e. Stability and solution concentration enhancement of resveratrol by solid dispersion in cellulose derivative matrices. Cellulose 20 (3):1249–60. doi: 10.1007/s10570-013-9889-3.
  • Li, J., I. W. Lee, G. H. Shin, X. Chen, and H. J. Park. 2015. Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin. European Journal of Pharmaceutics and Biopharmaceutics 94:322–32.
  • Li, N., C. J. Gilpin, and L. S. Taylor. 2017. Understanding the impact of water on the miscibility and microstructure of amorphous solid dispersions: An afm–lcr and tem–edx study. Molecular Pharmaceutics 14:1691–705.
  • Liu, C.-S., Y.-R. Zheng, Y.-F. Zhang, and X.-Y. Long. 2016. Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia 109:274–82. doi: 10.1016/j.fitote.2016.02.001.
  • Liu, C., K. G. Desai, C. Liu, and H. J. Park. 2004. Enhancement of dissolution rate of rofecoxib using solid dispersions with urea. Drug Development Research 63:181–9.
  • Liu, C., P. Tong, R. Yang, Y. You, H. Liu, and T. Zhang. 2019. Solidified phospholipid-TPGS as an effective oral delivery system for improving the bioavailability of resveratrol. Journal of Drug Delivery Science and Technology 52:769–77.
  • Luo, Y., P. Shang, and D. Li. 2017. Luteolin: A flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Frontiers in Pharmacology 8:692. doi: 10.3389/fphar.2017.00692.
  • Luu, T. D., B.-J. Lee, P. H. L. Tran, and T. T. D. Tran. 2019. Modified sprouted rice for modulation of curcumin crystallinity and dissolution enhancement by solid dispersion. Journal of Pharmaceutical Investigation 49 (1):127–34. doi: 10.1007/s40005-018-0393-5.
  • Ma, X., and R. O. Williams. 2019. Characterization of amorphous solid dispersions: An update. Journal of Drug Delivery Science and Technology 50:113–24. doi: 10.1016/j.jddst.2019.01.017.
  • Mannava, M. K., K. Suresh, M. Kumar Bommaka, D. Bhavani Konga, and A. Nangia. 2018. Curcumin-artemisinin coamorphous solid: Xenograft model preclinical study. Pharmaceutics 10 (1):7. doi: 10.3390/pharmaceutics10010007.
  • Matos, R. L., T. Lu, V. Prosapio, C. McConville, G. Leeke, and A. Ingram. 2019. Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process. Journal of CO2 Utilization 30:48–62. doi: 10.1016/j.jcou.2019.01.005.
  • Mcclements, D. J., L. Zou, R. Zhang, L. Salvia-Trujillo, T. Kumosani, and H. Xiao. 2015. Enhancing nutraceutical performance using excipient foods: Designing food structures and compositions to increase bioavailability. Comprehensive Reviews in Food Science and Food Safety 14 (6):824–47. doi: 10.1111/1541-4337.12170.
  • Mcginity, J. W., P. Maincent, and H. Steinfink. 1984. Crystallinity and dissolution rate of tolbutamide solid dispersions prepared by the melt method. Journal of Pharmaceutical Sciences 73 (10):1441–4. doi: 10.1002/jps.2600731030.
  • Meng, F., A. Trivino, D. Prasad, and H. Chauhan. 2015. Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 71:12–24. doi: 10.1016/j.ejps.2015.02.003.
  • Miyanishi, H., T. Nemoto, M. Mizuno, H. Mimura, S. Kitamura, Y. Iwao, S. Noguchi, and S. Itai. 2013. Evaluation of crystallization behavior on the surface of nifedipine solid dispersion powder using inverse gas chromatography. Pharmaceutical Research 30 (2):502–11. doi: 10.1007/s11095-012-0896-0.
  • Mou, H., X. Wang, T. Lv, L. Xie, and H. Xie. 2011. On-line dissolution determination of Baicalin in solid dispersion based on near infrared spectroscopy and circulation dissolution system. Chemometrics and Intelligent Laboratory Systems 105 (1):38–42. doi: 10.1016/j.chemolab.2010.10.008.
  • Mudila, H., P. Prasher, B. Khati, S. Kumar, and H. Punetha. 2018. Nutraceuticals for healthy sporting. In Nutraceuticals and innovative food products for healthy living and preventive care. Hershey, PA: IGI Global.
  • Mureşan-Pop, M., M. M. Pop, G. Borodi, M. Todea, T. Nagy-Simon, and S. Simon. 2017. Solid dispersions of Myricetin with enhanced solubility: Formulation, characterization and crystal structure of stability-impeding Myricetin monohydrate crystals. Journal of Molecular Structure 1141:607–14. doi: 10.1016/j.molstruc.2017.04.015.
  • Nadal, J. M., M. L. S. Gomes, D. B. M. Borsato, M. A. Almeida, F. M. Barboza, S. N. F. Zawadzki, P. V. Farago, and S. M. W. Zanin. 2016. Spray-dried solid dispersions containing ferulic acid: Comparative analysis of three carriers, in vitro dissolution, antioxidant potential and in vivo anti-platelet effect. Drug Development and Industrial Pharmacy 42 (11):1813–24. doi: 10.3109/03639045.2016.1173055.
  • Nair, A., R. Varma, K. Gourishetti, K. Bhat, and S. Dengale. 2019. Influence of preparation methods on physicochemical and pharmacokinetic properties of co-amorphous formulations: The case of co-amorphous atorvastatin. Naringin Journal of Pharmaceutical Innovation 17:1–15.
  • Ng, C. L., S.-E. Lee, J.-K. Lee, T.-H. Kim, W. S. Jang, J.-S. Choi, Y.-H. Kim, J.-K. Kim, and J.-S. Park. 2016. Solubilization and formulation of chrysosplenol C in solid dispersion with hydrophilic carriers. International Journal of Pharmaceutics 512 (1):314–21. doi: 10.1016/j.ijpharm.2016.08.062.
  • Nishitani, Y., K. Yamamoto, M. Yoshida, T. Azuma, K. Kanazawa, T. Hashimoto, and M. Mizuno. 2013. Intestinal anti-inflammatory activity of luteolin: Role of the aglycone in NF-κB inactivation in macrophages co-cultured with intestinal epithelial cells. BioFactors (Oxford, England) 39 (5):522–33. doi: 10.1002/biof.1091.
  • Onoue, S., A. Uchida, H. Takahashi, Y. Seto, Y. Kawabata, K. Ogawa, K. Yuminoki, N. Hashimoto, and S. Yamada. 2011. Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. Journal of Pharmaceutical Sciences 100 (9):3793–801. doi: 10.1002/jps.22585.
  • Otto, D. P., A. Otto, and M. M. DE Villiers. 2013. Experimental and mesoscale computational dynamics studies of the relationship between solubility and release of quercetin from PEG solid dispersions. International Journal of Pharmaceutics 456 (2):282–92. doi: 10.1016/j.ijpharm.2013.08.039.
  • Pai, D. A., V. R. Vangala, J. W. Ng, W. K. Ng, and R. B. H. Tan. 2015. Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization. Journal of Food Engineering 161:68–74. doi: 10.1016/j.jfoodeng.2015.03.037.
  • Paliwal, R., R. J. Babu, and S. Palakurthi. 2014. Nanomedicine scale-up technologies: Feasibilities and challenges. Aaps Pharmscitech 15 (6):1527–34. doi: 10.1208/s12249-014-0177-9.
  • Pandi, P., R. Bulusu, N. Kommineni, W. Khan, and M. Singh. 2020. Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products. International Journal of Pharmaceutics 586 :119560.
  • Pang, W., J. Lv, S. Du, J. Wang, J. Wang, and Y. Zeng. 2017. Preparation of curcumin-piperazine coamorphous phase and fluorescence spectroscopic and density functional theory simulation studies on the interaction with bovine serum albumin. Molecular Pharmaceutics 14 (9):3013–24. doi: 10.1021/acs.molpharmaceut.7b00217.
  • Paradkar, A., A. A. Ambike, B. K. Jadhav, and K. R. Mahadik. 2004. Characterization of curcumin-PVP solid dispersion obtained by spray drying. International Journal of Pharmaceutics 271 (1–2):281–6. doi: 10.1016/j.ijpharm.2003.11.014.
  • Pauck, C., D. DE Beer, M. Aucamp, W. Liebenberg, N. Stieger, C. Human, and E. Joubert. 2017. Inulin suitable as reduced-kilojoule carrier for production of microencapsulated spray-dried green cyclopia subternata (honeybush) extract. LWT 75:631–9.
  • Paudel, A., Z. A. Worku, J. Meeus, S. Guns, and G. van den Mooter. 2013. Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations. International Journal of Pharmaceutics 453 (1):253–84. doi: 10.1016/j.ijpharm.2012.07.015.
  • Prasad, S., A. K. Tyagi, and B. B. Aggarwal. 2014. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Research and Treatment: Official Journal of Korean Cancer Association 46 (1):2–18. doi: 10.4143/crt.2014.46.1.2.
  • Prosapio, V., E. Reverchon, and I. De Marco. 2015. Coprecipitation of polyvinylpyrrolidone/β-carotene by supercritical antisolvent processing. Industrial & Engineering Chemistry Research 54:11568–75.
  • Qian, S., W. Heng, Y. Wei, J. Zhang, and Y. Gao. 2015. Coamorphous lurasidone hydrochloride–saccharin with charge-assisted hydrogen bonding interaction shows improved physical stability and enhanced dissolution with pH-independent solubility behavior. Crystal Growth & Design 15 (6):2920–8. doi: 10.1021/acs.cgd.5b00349.
  • Remenar, J. F., S. L. Morissette, M. L. Peterson, B. Moulton, J. M. MacPhee, H. R. Guzmán, and O. Almarsson. 2003. Crystal engineering of novel cocrystals of a triazole drug with 1,4-dicarboxylic acids. Journal of the American Chemical Society 125 (28):8456–7. doi: 10.1021/ja035776p.
  • Sahebkar, A., M.-C. Serban, S. Ursoniu, and M. Banach. 2015. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods 18:898–909. doi: 10.1016/j.jff.2015.01.005.
  • Schittny, A., J. Huwyler, and M. Puchkov. 2020. Mechanisms of increased bioavailability through amorphous solid dispersions: A review. Drug Delivery 27 (1):110–27. doi: 10.1080/10717544.2019.1704940.
  • Sekitoh, T., T. Okamoto, A. Fujioka, O. Tramis, K. Takeda, T. Matsuura, H. Imanaka, N. Ishida, and K. Imamura. 2020. Sole-amorphous-sugar-based solid dispersion of curcumin and the influence of formulation composition and heat treatment on the dissolution of curcumin. Drying Technology 38:1–10.
  • Seo, S.-W., H.-K. Han, M.-K. Chun, and H.-K. Choi. 2012. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier. International Journal of Pharmaceutics 424 (1–2):18–25. doi: 10.1016/j.ijpharm.2011.12.051.
  • Shi, C., Q. Tong, J. Fang, C. Wang, J. Wu, and W. Wang. 2015. Preparation, characterization and in vivo studies of amorphous solid dispersion of berberine with hydrogenated phosphatidylcholine. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 74:11–7. doi: 10.1016/j.ejps.2015.04.001.
  • Shi, X., N. Fan, G. Zhang, J. Sun, Z. He, and J. Li. 2020. Quercetin amorphous solid dispersions prepared by hot melt extrusion with enhanced solubility and intestinal absorption. Pharmaceutical Development and Technology 25 (4):472–10. doi: 10.1080/10837450.2019.1709502.
  • Shin, M.-S., J. S. Yu, J. Lee, Y. S. Ji, H. J. Joung, Y.-M. Han, H. H. Yoo, and K. S. Kang. 2019. A hydroxypropyl methylcellulose-based solid dispersion of curcumin with enhanced bioavailability and its hepatoprotective activity. Biomolecules, 9, 281.
  • Skieneh, J. M., I. Sathisaran, S. V. Dalvi, and S. Rohani. 2017. Co-amorphous form of curcumin–folic acid dihydrate with increased dissolution rate. Crystal Growth & Design 17:6273–80.
  • Song, I.-S., J.-S. Cha, and M.-K. Choi. 2016. Characterization, in vivo and in vitro evaluation of solid dispersion of curcumin containing d-α-Tocopheryl polyethylene glycol 1000 succinate and mannitol. Molecules 21 (10):1386. doi: 10.3390/molecules21101386.
  • Sotthivirat, S., C. Mckelvey, J. Moser, B. Rege, W. Xu, and D. Zhang. 2013. Development of amorphous solid dispersion formulations of a poorly water-soluble drug, MK-0364. International Journal of Pharmaceutics 452 (1–2):73–81. doi: 10.1016/j.ijpharm.2013.04.037.
  • Stoyanova, N., M. Spasova, N. Manolova, I. Rashkov, A. Georgieva, and R. Toshkova. 2020. Antioxidant and antitumor activities of novel quercetin-loaded electrospun cellulose acetate/polyethylene glycol fibrous materials. Antioxidants 9 (3):232. doi: 10.3390/antiox9030232.
  • Summerlin, N., Z. Qu, N. Pujara, Y. Sheng, S. Jambhrunkar, M. Mcguckin, and A. Popat. 2016. Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces. B, Biointerfaces 144:1–7. doi: 10.1016/j.colsurfb.2016.03.076.
  • Sun, N., X. Wei, B. Wu, J. Chen, Y. Lu, and W. Wu. 2008. Enhanced dissolution of silymarin/polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluid-bed coating technique. Powder Technology 182 (1):72–80. doi: 10.1016/j.powtec.2007.05.029.
  • Suresh, K., M. K. C. Mannava, and A. Nangia. & 2014. A novel curcumin-artemisinin coamorphous solid: Physical properties and pharmacokinetic profile. Rsc Advances 4 (102):58357–61. doi: 10.1039/C4RA11935E.
  • Teja, A., P. B. Musmade, A. B. Khade, and S. J. Dengale. 2015. Simultaneous improvement of solubility and permeability by fabricating binary glassy materials of Talinolol with Naringin: Solid state characterization, in-vivo in-situ evaluation. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 78:234–44. doi: 10.1016/j.ejps.2015.08.002.
  • Telang, C., S. Mujumdar, and M. Mathew. 2009. Improved physical stability of amorphous state through acid base interactions. Journal of Pharmaceutical Sciences 98 (6):2149–59. doi: 10.1002/jps.21584.
  • Teng, Z., Y. Luo, and Q. Wang. 2012. Nanoparticles synthesized from soy protein: Preparation, characterization, and application for nutraceutical encapsulation. Journal of Agricultural and Food Chemistry 60 (10):2712–20. doi: 10.1021/jf205238x.
  • Thenmozhi, K., and Y. J. Yoo. 2017. Enhanced solubility of piperine using hydrophilic carrier-based potent solid dispersion systems. Drug Development and Industrial Pharmacy 43 (9):1501–9. doi: 10.1080/03639045.2017.1321658.
  • Ting, Y., Y. Jiang, C.-T. Ho, and Q. Huang. 2014. Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. Journal of Functional Foods 7:112–28. doi: 10.1016/j.jff.2013.12.010.
  • Tsekova, P. B., M. G. Spasova, N. E. Manolova, N. D. Markova, and I. B. Rashkov. 2017. Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity. Materials Science & Engineering. C, Materials for Biological Applications 73:206–14. doi: 10.1016/j.msec.2016.12.086.
  • Vasconcelos, T., S. Marques, J. DAS Neves, and B. Sarmento. 2016. Amorphous solid dispersions: Rational selection of a manufacturing process. Advanced Drug Delivery Reviews 100:85–101. doi: 10.1016/j.addr.2016.01.012.
  • Vukićević, M., A. B. Hegge, P. Vulić, and H. H. Tønnesen. 2015. Poloxamer-based curcumin solid dispersions for ex tempore preparation of supersaturated solutions intended for antimicrobial photodynamic therapy. Pharmaceutical Development and Technology 20 (7):863–71. doi: 10.3109/10837450.2014.930489.
  • Walle, T., F. Hsieh, M. H. Delegge, J. E. Oatis, and U. K. Walle. 2004. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metabolism and Disposition 32 (12):1377–82. doi: 10.1124/dmd.104.000885.
  • Wang, C., C. Ma, Z. Wu, H. Liang, P. Yan, J. Song, N. Ma, and Q. Zhao. 2015a. Enhanced bioavailability and anticancer effect of curcumin-loaded electrospun nanofiber: In vitro and in vivo study. Nanoscale Research Letters 10 (1):1–10. doi: 10.1186/s11671-015-1146-2.
  • Wang, W., Q. Kang, N. Liu, Q. Zhang, Y. Zhang, H. Li, B. Zhao, Y. Chen, Y. Lan, Q. Ma, et al. 2015b. Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. Fitoterapia 102:189–97. doi: 10.1016/j.fitote.2014.10.004.
  • Wang, L.-M., V. Velikov, and C. A. Angell. 2002. Direct determination of kinetic fragility indices of glassforming liquids by differential scanning calorimetry: Kinetic versus thermodynamic fragilities. The Journal of Chemical Physics 117 (22):10184–92. doi: 10.1063/1.1517607.
  • Wang, R., J. Han, A. Jiang, R. Huang, T. Fu, L. Wang, Q. Zheng, W. Li, and J. Li. 2019. Involvement of metabolism-permeability in enhancing the oral bioavailability of curcumin in excipient-free solid dispersions co-formed with piperine. International Journal of Pharmaceutics 561:9–18. doi: 10.1016/j.ijpharm.2019.02.027.
  • Wegiel, L. A., L. J. Mauer, K. J. Edgar, and L. S. Taylor. 2013. Crystallization of amorphous solid dispersions of resveratrol during preparation and storage-Impact of different polymers. Journal of Pharmaceutical Sciences 102 (1):171–84. doi: 10.1002/jps.23358.
  • Wegiel, L. A., L. I. Mosquera-Giraldo, L. J. Mauer, K. J. Edgar, and L. S. Taylor. 2015. Phase behavior of resveratrol solid dispersions upon addition to aqueous media. Pharmaceutical Research 32 (10):3324–37. doi: 10.1007/s11095-015-1709-z.
  • Wegiel, L. A., Y. Zhao, L. J. Mauer, K. J. Edgar, and L. S. Taylor. 2014. Curcumin amorphous solid dispersions: The influence of intra and intermolecular bonding on physical stability. Pharmaceutical Development and Technology 19 (8):976–86. doi: 10.3109/10837450.2013.846374.
  • Wei, Y., S. Zhou, T. Hao, J. Zhang, Y. Gao, and S. Qian. 2019. Further enhanced dissolution and oral bioavailability of docetaxel by coamorphization with a natural P-gp inhibitor myricetin. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 129:21–30. doi: 10.1016/j.ejps.2018.12.016.
  • Weng, C.-J., M.-J. Chen, C.-T. Yeh, and G.-C. Yen. 2011. Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity. New Biotechnology 28 (6):767–77. doi: 10.1016/j.nbt.2011.05.003.
  • Wong, J. J. L., H. Yu, L. M. Lim, and K. Hadinoto. 2018. A trade-off between solubility enhancement and physical stability upon simultaneous amorphization and nanonization of curcumin in comparison to amorphization alone. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 114:356–63. doi: 10.1016/j.ejps.2018.01.010.
  • Xu, W., M. Wen, J. Yu, Q. Zhang, N. E. Polyakov, A. V. Dushkin, and W. Su. 2018. Mechanochemical preparation of kaempferol intermolecular complexes for enhancing the solubility and bioavailability. Drug Development and Industrial Pharmacy 44 (12):1924–32. doi: 10.1080/03639045.2018.1503292.
  • Yang, D. K., and H.-S. Kang. 2018. Anti-diabetic effect of cotreatment with quercetin and resveratrol in streptozotocin-induced diabetic rats. Biomolecules & Therapeutics 26 (2):130–8. doi: 10.4062/biomolther.2017.254.
  • Yang, G., Y. Zhao, N. Feng, Y. Zhang, Y. Liu, and B. Dang. 2015. Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids. Asian Journal of Pharmaceutical Sciences 10:194–202.
  • Zhang, Q., L. Suntsova, Y. S. Chistyachenko, V. Evseenko, M. V. Khvostov, N. E. Polyakov, A. V. Dushkin, and W. Su. 2019. Preparation, physicochemical and pharmacological study of curcumin solid dispersion with an arabinogalactan complexation agent. International Journal of Biological Macromolecules 128:158–66. doi: 10.1016/j.ijbiomac.2019.01.079.
  • Zhang, X., H. Xing, Y. Zhao, and Z. Ma. 2018. Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs. Pharmaceutics 10 (3):74. doi: 10.3390/pharmaceutics10030074.
  • Zhang, Z., Y. Chen, J. Deng, X. Jia, J. Zhou, and H. Lv. 2014. Solid dispersion of berberine–phospholipid complex/TPGS 1000/SiO2: Preparation, characterization and in vivo studies. International Journal of Pharmaceutics 465 (1–2):306–16. doi: 10.1016/j.ijpharm.2014.01.023.
  • Zhaojie, M., Z. Ming, W. Shengnan, B. Xiaojia, G. M. Hatch, G. Jingkai, and C. Li. 2014. Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability. International Journal of Pharmaceutics 467 (1–2):50–9. doi: 10.1016/j.ijpharm.2014.03.017.
  • Zhu, C., S. Gong, J. Ding, M. Yu, E. Ahmad, Y. Feng, and Y. Gan. 2019. Supersaturated polymeric micelles for oral silybin delivery: The role of the Soluplus-PVPVA complex. Acta Pharmaceutica Sinica. B 9 (1):107–17. doi: 10.1016/j.apsb.2018.09.004.
  • Zhu, S., H. Gao, S. Babu, and S. Garad. 2018. Co-amorphous formation of high-dose zwitterionic compounds with amino acids to improve solubility and enable parenteral delivery. Molecular Pharmaceutics 15 (1):97–107. doi: 10.1021/acs.molpharmaceut.7b00738.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.