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The impact of the micronutrient iodine in health and diseases

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References

  • Aburto, .N., M. Abudou, V. Candeias, T. Wu. 2014. Effect and safety of salt iodization to prevent iodine deficiency disorders: a systematic review with meta-analyses. WHO eLibrary of Evidence for Nutrition Actions (eLENA). Geneva: World Health Organization.
  • Adams, J. B., C. E. Holloway, F. George, and D. Quig. 2006. Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers. Biological Trace Element Research 110 (3):193–209. doi: 10.1385/BTER:110:3:193.
  • Ahad, F., and S. A. Ganie. 2010. Iodine, iodine metabolism and iodine deficiency disorders revisited. Indian Journal of Endocrinology and Metabolism 14 (1):13–7. http://www.ncbi.nlm.nih.gov/pubmed/21448409.
  • Albornoz, E. A., L. J. Carreño, C. M. Cortes, P. A. Gonzalez, P. A. Cisternas, K. M. Cautivo, T. P. Catalán, M. C. Opazo, E. A. Eugenin, J. W. Berman, et al. 2013. Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring. Thyroid 23 (12):1627–37. doi: 10.1089/thy.2012.0401.
  • Alexander, E. K., E. N. Pearce, G. A. Brent, R. S. Brown, H. Chen, C. Dosiou, W. A. Grobman, P. Laurberg, J. H. Lazarus, S. J. Mandel, et al. 2017. 2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid 27 (3):315–89. doi: 10.1089/thy.2016.0457.
  • Amachi, S., Y. Mishima, H. Shinoyama, Y. Muramatsu, and T. Fujii. 2005. Active transport and accumulation of iodide by newly isolated marine bacteria. Applied and Environmental Microbiology 71 (2):741–5. doi: 10.1128/AEM.71.2.741-745.2005.
  • Antonelli, A., S. M. Ferrari, A. Corrado, A. Di Domenicantonio, and P. Fallahi. 2015. Autoimmune thyroid disorders. Autoimmunity Reviews 14 (2):174–80. doi: 10.1016/j.autrev.2014.10.016.
  • Antonelli, A., S. M. Ferrari, D. Giuggioli, E. Ferrannini, C. Ferri, and P. Fallahi. 2014. Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases. Autoimmunity Reviews 13 (3):272–80. doi: 10.1016/j.autrev.2013.10.010.
  • Bath, S. C., V. J. Pop, V. L. Furmidge-Owen, M. A. Broeren, and M. P. Rayman. 2017. Thyroglobulin as a functional biomarker of iodine status in a cohort study of pregnant women in the United Kingdom. Thyroid 27 (3):426–33. doi: 10.1089/thy.2016.0322.
  • Becker, L. K., J. P. Bilezikian, and Ovid Technologies, Inc. 2001. Part III: The thyroid gland. In Principles and practice of endocrinology and metabolism. Philadelphia, PA: Lippincott Williams & Wilkins Publishers.
  • Bianco, A. C., and R. R. da Conceição. 2018. The deiodinase trio and thyroid hormone signaling. Methods in molecular biology 1801: 67–83. New York, NY: Humana Press Inc. doi: 10.1007/978-1-4939-7902-8_8.
  • Bianco, A. C., D. Salvatore, B. Gereben, M. J. Berry, and P. R. Larsen. 2002. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Reviews 23 (1):38–89. doi: 10.1210/edrv.23.1.0455.
  • Bizhanova, A., and P. Kopp. 2009. Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology 150 (3):1084–90. doi: 10.1210/en.2008-1437.
  • Błażewicz, A., A. Makarewicz, I. Korona-Glowniak, W. Dolliver, and R. Kocjan. 2016. Iodine in autism spectrum disorders. Journal of Trace Elements in Medicine and Biology 34:32–7. doi: 10.1016/j.jtemb.2015.12.002.
  • Bourdoux, P., F. Delange, M. Gerard, M. Mafuta, A. Hanson, and A. M. Ermans. 1978. Evidence that cassava ingestion increases thiocyanate formation: A possible etiologic factor in endemic goiter*. The Journal of Clinical Endocrinology and Metabolism 46 (4):613–21. doi: 10.1210/jcem-46-4-613.
  • Braverman, L. E., X. M. He, S. Pino, M. Cross, B. Magnani, S. H. Lamm, M. B. Kruse, A. Engel, K. S. Crump, and J. P. Gibbs. 2005. The effect of perchlorate, thiocyanate, and nitrate on thyroid function in workers exposed to perchlorate long-term. The Journal of Clinical Endocrinology & Metabolism 90 (2):700–6. doi: 10.1210/jc.2004-1821.
  • Brenta, G., M. Vaisman, J. A. Sgarbi, L. M. Bergoglio, N. C. Andrada, P. P. Bravo, A. M. Orlandi, H. Graf, and Society Task Force on Hypothyroidism of the Latin American Thyroid. 2013. Clinical practice guidelines for the management of hypothyroidism. Arquivos Brasileiros de Endocrinologia e Metabologia 57 (4):265–91. doi: 10.1590/s0004-27302013000400003.
  • Cabeca, T. K., A. C. Pizzolitto, and E. L. Pizzolitto. 2012. Activity of disinfectants against foodborne pathogens in suspension and adhered to stainless steel surfaces. Brazilian Journal of Microbiology 43 (3):1112–9. doi: 10.1590/S1517-838220120003000038.
  • Carvalho, D. P., and C. Dupuy. 2017. Thyroid hormone biosynthesis and release. Molecular and Cellular Endocrinology 458:6–15. doi: 10.1016/j.mce.2017.01.038.
  • Catalanotto, C., C. Cogoni, and G. Zardo. 2016. MicroRNA in control of gene expression: An overview of nuclear functions. International Journal of Molecular Sciences 17 (10):1712. 10.3390/ijms17101712.
  • Caufield, P. W., and Y. M. Wannemuehler. 1982. In vitro susceptibility of Streptococcus mutans 6715 to iodine and sodium fluoride, singly and in combination, at various PH values. Antimicrobial Agents and Chemotherapy 22 (1):115–9. doi: 10.1128/AAC.22.1.115.
  • Cavalieri, R. R. 1997. Iodine metabolism and thyroid physiology: Current concepts. Thyroid 7 (2):177–81. doi: 10.1089/thy.1997.7.177.
  • Chang, K., and J. I. Shin. 2014. Association of gestational maternal hypothyroxinemia and increased autism risk: The role of brain-derived neurotrophic factor. Annals of Neurology 75 (6):971. doi: 10.1002/ana.24143.
  • Chaves Lopez, C., A. Serio, C. Rossi, G. Mazzarrino, S. Marchetti, F. Castellani, L. Grotta, F. P. Fiorentino, A. Paparella, and G. Martino. 2016. Effect of diet supplementation with Ascophyllum nodosum on cow milk composition and microbiota. Journal of Dairy Science 99 (8):6285–97. doi: 10.3168/jds.2015-10837.
  • Cheng, S.-Y., J. L. Leonard, and P. J. Davis. 2010. Molecular aspects of thyroid hormone actions. Endocrine Reviews 31 (2):139–70. doi: 10.1210/er.2009-0007.
  • Chung, H. R. 2014. Iodine and thyroid function. Annals of Pediatric Endocrinology & Metabolism 19 (1):8–12. doi: 10.6065/apem.2014.19.1.8.
  • Cisternas, P., A. Louveau, S. M. Bueno, A. M. Kalergis, H. Boudin, and C. A. Riedel. 2016. Gestational hypothyroxinemia affects glutamatergic synaptic protein distribution and neuronal plasticity through neuron-astrocyte interplay. Molecular Neurobiology 53 (10):7158–69. doi: 10.1007/s12035-015-9609-0.
  • Colony, P. C. 1983. Successive phases of human fetal intestinal development. In Nutritional adaptation of the gastrointestinal tract of the newborn, eds. N. Kretchmer and A. Minkows, 3–28. New York: Nestlé, Vevey/RavenPress.
  • Cuevas, E., E. Auso, M. Telefont, G. Morreale de Escobar, C. Sotelo, and P. Berbel. 2005. Transient maternal hypothyroxinemia at onset of corticogenesis alters tangential migration of medial ganglionic eminence-derived neurons. The European Journal of Neuroscience 22 (3):541–51. doi: 10.1111/j.1460-9568.2005.04243.x.
  • Dai, J. L., Y. G. Zhu, M. Zhang, and Y. Z. Huang. 2004. Selecting iodine-enriched vegetables and the residual effect of iodate application to soil. Biological Trace Element Research 101 (3):265–76. doi: 10.1385/BTER. :101:3:265.
  • Dauksiene, D., J. Petkeviciene, J. Klumbiene, R. Verkauskiene, J. Vainikonyte-Kristapone, A. Seibokaite, J. Ceponis, V. Sidlauskas, L. Daugintyte-Petrusiene, A. Norkus, et al. 2017. Factors associated with the prevalence of thyroid nodules and goiter in middle-aged euthyroid subjects. International Journal of Endocrinology. 2017:1–8. doi: 10.1155/2017/8401518.
  • Davis, P. J., F. Goglia, and J. L. Leonard. 2016. Nongenomic actions of thyroid hormone. Nature Reviews. Endocrinology 12 (2):111–21. doi: 10.1038/nrendo.2015.205.
  • De Groef, B., B. R. Decallonne, S. V. d Geyten, V. M. Darras, and R. Bouillon. 2006. Perchlorate versus other environmental sodium/iodide symporter inhibitors: Potential thyroid-related health effects. European Journal of Endocrinology 155 (1):17–25. doi: 10.1530/eje.1.02190.
  • Di Jeso, B., and P. Arvan. 2016. Thyroglobulin from molecular and cellular biology to clinical endocrinology. Endocrine Reviews 37 (1):2–36. doi: 10.1210/er.2015-1090.
  • Diamanti-Kandarakis, E., J. P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. T. Zoeller, and A. C. Gore. 2009. Endocrine-disrupting chemicals: An endocrine society scientific statement. Endocrine Reviews 30 (4):293–342. doi: 10.1210/er.2009-0002.
  • Dohán, O., C. Portulano, C. Basquin, A. Reyna-Neyra, L. M. Amzel, and N. Carrasco. 2007. The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate . Proceedings of the National Academy of Sciences of the United States of America 104 (51):20250–55. doi: 10.1073/pnas.0707207104.
  • Dosiou, C., and M. Medici. 2017. MANAGEMENT OF ENDOCRINE DISEASE: Isolated maternal hypothyroxinemia during pregnancy: Knowns and unknowns. European Journal of Endocrinology 176 (1):R21–R38. doi: 10.1530/EJE-16-0354.
  • Drutel, A., F. Archambeaud, and P. Caron. 2013. Selenium and the thyroid gland: More good news for clinicians. Clinical Endocrinology 78 (2):155–164. doi: 10.1111/cen.12066.
  • Dunn, D., and C. Turner. 2016. Hypothyroidism in Women. Nursing for Women’s Health 20 (1):93–98. doi: 10.1016/j.nwh.2015.12.002.
  • Dunn, J. T. 1993. Iodine supplementation and the prevention of cretinism. Annals of the New York Academy of Sciences 678:158–68. doi: 10.1111/j.1749-6632.1993.tb26119.x.
  • Dzhatdoeva, F. A., L. E. Syrtsova, G. A. Gerasimov, T. E. Zubrilova, and Z. N. Salpagarova. 2005. [Prevention of iodine-deficient diseases]. Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med Jan–Feb(1):25–26. http://www.ncbi.nlm.nih.gov/pubmed/15828388.
  • Eastman, C. J., and M. Li. 2017. Mild to moderate iodine deficiency. In Iodine deficiency disorders and their elimination, ed. E. N. Pearce, 59–74. Cham: Springer International Publishing. doi: 10.1007/978-3-319-49505-7_5.
  • Ebmeier, C. C., and R. J. Anderson. 2004. Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: Activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens. The Journal of Clinical Endocrinology and Metabolism 89 (11):5597–5605. doi: 10.1210/jc.2003-031939.
  • FAO and WHO. 2001. FAO/WHO expert consultation on human vitamin and mineral requirements. Report of a Joint FAO/WHO Expert Consultation.
  • Fardella, C., S. Gloger, R. Figueroa, R. Santis, C. Gajardo, C. Salgado, S. Barroilhet, and A. Foradori. 2000. High prevalence of thyroid abnormalities in a Chilean psychiatric outpatient population. Journal of Endocrinological Investigation 23 (2):102–6. doi: 10.1007/BF03343687.
  • Farebrother, J., M. B. Zimmermann, and M. Andersson. 2019. Excess iodine intake: Sources, assessment, and effects on thyroid function. Annals of the New York Academy of Sciences 1446 (1):44–65. doi: 10.1111/nyas.14041.
  • Featherstone, J. D. 2006. Delivery challenges for fluoride, chlorhexidine and xylitol. BMC Oral Health 6 Suppl 1:S8. doi: 10.1186/1472-6831-6-S1-S8.
  • Finley, J. W. 2006. Bioavailability of selenium from foods. Nutrition Reviews 64 (3):146–151. doi: 10.1301/nr.2006.mar.146-151.
  • Foster, M., E. Montecino-Rodriguez, R. Clark, and K. Dorshkind. 1998. Regulation of B and T cell development by anterior pituitary hormones. Cellular and Molecular Life Sciences 54 (10):1076–82. doi: 10.1007/s000180050236.
  • Fuge, R., and C. C. Johnson. 1986. The geochemistry of iodine—A review. Environmental Geochemistry and Health 8 (2):31–54. doi: 10.1007/BF02311063.
  • Gaitan, E. 1990. Goitrogens in food and water. Annual Review of Nutrition 10:21–39. doi: 10.1146/annurev.nu.10.070190.000321.
  • Gao, T., H. Fan, X. Wang, Y. Gao, W. Liu, W. Chen, A. Dong, and Y. J. Wang. 2017. Povidone-iodine-based polymeric nanoparticles for antibacterial applications. ACS Applied Materials & Interfaces 9 (31):25738–46. doi: 10.1021/acsami.7b05622.
  • Gizak, M., J. Gorstein, and M. Andersson. 2017. Epidemiology of iodine deficiency. In Iodine deficiency disorders and their elimination, ed. E. Pearce. Cham: Springer. 10.1007/978-3-319-49505-7_3.
  • Gloger, S., C. Fardella, C. Gajardo, R. Figueroa, C. Salgado, R. Santis, and S. Barroilhet. 2001. [Panic disorder and hyperthyroidism. Report of 2 cases]. Revista Medica de Chile 129 (2):187–90. http://www.ncbi.nlm.nih.gov/pubmed/11351471.
  • Haensgen, H., E. Albornoz, M. C. Opazo, K. Bugueño, E. L. Jara Fernández, R. Binzberger, T. Rivero-Castillo, L. F. Venegas Salas, F. Simon, C. Cabello-Verrugio, et al. 2018. Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis. Frontiers in Immunology 9:1257. doi: 10.3389/fimmu.2018.01257.
  • Hamza, R. T., D. H. Hewedi, and M. T. Sallam. 2013. Iodine deficiency in Egyptian autistic children and their mothers: Relation to disease severity. Archives of Medical Research 44 (7):555–61. doi: 10.1016/j.arcmed.2013.09.012.
  • Harper, K. N., and A. S. Brown. 2012. Prenatal nutrition and the etiology of schizophrenia. In The origins of schizophrenia, ed. A. S. Brown and P. H. Patterson, 58–95. New York: Columbia University Press.
  • Henrichs, J., A. Ghassabian, R. P. Peeters, and H. Tiemeier. 2013. Maternal hypothyroxinemia and effects on cognitive functioning in childhood: How and why? Clinical Endocrinology 79 (2):152–62. doi: 10.1111/cen.12227.
  • IGN. 2017. Iodine Global Network. Global Scorecard of Iodine Nutrition in 2017 in the General Population and in Pregnant Women (PW). Zurich, Switzerland: IGN.
  • Institute of Medicine (US) Panel on Micronutrients. 2001. Iodine . In Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK222310/.
  • Iodine: Fact sheet by the Office of Dietary Supplements (ODS). 2011. https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/#en2.
  • Ishaq, H. M., I. S. Mohammad, H. Guo, M. Shahzad, Y. J. Hou, C. Ma, Z. Naseem, X. Wu, P. Shi, and J. Xu. 2017. Molecular estimation of alteration in intestinal microbial composition in Hashimoto’s thyroiditis patients. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 95:865–74. doi: 10.1016/j.biopha.2017.08.101.
  • Janssen, S. T., and O. E. Janssen. 2017. Directional thyroid hormone distribution via the blood stream to target sites. Molecular and Cellular Endocrinology 458:16–21. doi: 10.1016/j.mce.2017.02.037.
  • Johnson, C. C. 2003. The geochemistry of iodine and its application to environmental strategies for reducing the risks from iodine deficiency disorders. British Geological Survey Commissioned Report, CR/03/057N. 54 pp.
  • Jong, J. M. d. 2007. Final report review of use of iodized salt in processed foods. Global Iodine Network. 2007. http://www.iccidd.org/cm_data/Salt_in_processed_foods.pdf.
  • Josefsson, M., and E. Ekblad. 2009. Chapter 22—Sodium iodide symporter (NIS) in gastric mucosa: Gastric iodide secretion A2—Preedy, Edited ByVictor R. In Comprehensive handbook of iodine, ed. G. N. Burrow and R. Watson, 215–20. San Diego: Academic Press. 10.1016/B978-0-12-374135-6.00022-4.
  • Kapil, U. 2007. Health consequences of iodine deficiency. Sultan Qaboos University Medical Journal 7 (3):267–72. http://www.ncbi.nlm.nih.gov/pubmed/21748117.
  • Karmarkar, M. G., N. Kochupillai, M. G. Deo, and V. Ramalingaswami. 1969. Adaptation of thyroid gland to iodine deficiency. Life Sciences 8 (21):1135–41. doi: 10.1016/0024-3205(69)90042-3.
  • Katagiri, R., X. Yuan, S. Kobayashi, and S. Sasaki. 2017. Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies. PLoS One 12 (3):e0173722. doi: 10.1371/journal.pone.0173722.
  • Kawai, M., Y. Shoji, S. Onuma, Y. Etani, and S. Ida. 2018. Thyroid hormone status in patients with severe selenium deficiency. Clinical Pediatric Endocrinology 27 (2):67–74. doi: 10.1297/cpe.27.67.
  • Klebanoff, S. J. 1967. Iodination of bacteria: A bactericidal mechanism. The Journal of Experimental Medicine 126 (6):1063–78. doi: 10.1084/jem.126.6.1063.
  • Klebanoff, S. J., and W. L. Green. 1973. Degradation of thyroid hormones by phagocytosing human leukocytes. The Journal of Clinical Investigation 52 (1):60–72. doi: 10.1172/JCI107174.
  • Klein, I., and S. Danzi. 2016. Thyroid disease and the heart. Current Problems in Cardiology 41 (2):65–92. doi: 10.1016/j.cpcardiol.2015.04.002.
  • Köhrle, J. 2005. Selenium and the control of thyroid hormone metabolism. Thyroid 15 (8):841–53. doi: 10.1089/thy.2005.15.841.
  • Köhrle, J. 2015. Selenium and the thyroid. Current Opinion in Endocrinology, Diabetes, and Obesity 22 (5):392–401. doi:10.1097/MED.0000000000000190. PMID: 26313901
  • Korzeniewski, S. J., J. A. Pinto-Martin, A. H. Whitaker, J. F. Feldman, J. M. Lorenz, S. E. Levy, T. Z. Movsas, A. Pappas, and N. Paneth. 2013. Association between transient hypothyroxinaemia of prematurity and adult autism spectrum disorder in a low-birthweight cohort: An exploratory study. Paediatric and Perinatal Epidemiology 27 (2):182–7. doi: 10.1111/ppe.12034.
  • Korzh, V. D. 1984. Ocean as a source of atmospheric iodine. Atmospheric Environment 18 (12):2707–10. doi: 10.1016/0004-6981. (84)90336-6.
  • Kovalyuk, N., I. Kaiserman, M. Mimouni, O. Cohen, S. Levartovsky, H. Sherbany, and M. Mandelboim. 2017. Treatment of adenoviral keratoconjunctivitis with a combination of povidone-iodine 1.0% and dexamethasone 0.1% drops: A clinical prospective controlled randomized study. Acta Ophthalmologica 95 (8):e686. doi: 10.1111/aos.13416.
  • La Vignera, S., R. Vita, R. A. Condorelli, L. M. Mongioi, S. Presti, S. Benvenga, and A. E. Calogero. 2017. Impact of thyroid disease on testicular function. Endocrine 58 (3):397–407. doi: 10.1007/s12020-017-1303-8.
  • Lakshmanan, A., A. Wojcicka, M. Kotlarek, X. Zhang, K. Jazdzewski, and S. M. Jhiang. 2015. MicroRNA-339-5p modulates Na+/I- symporter-mediated radioiodide uptake. Endocrine-Related Cancer 22 (1):11–21. doi: 10.1530/ERC-14-0439.
  • Larisch, R., K. Kley, S. Nikolaus, W. Sitte, M. Franz, H. Hautzel, W. Tress, and H. W. Muller. 2004. Depression and anxiety in different thyroid function states. Hormone and Metabolic Research 36 (9):650–53. doi: 10.1055/s-2004-825925.
  • Laurberg, P., C. Cerqueira, L. Ovesen, L. B. Rasmussen, H. Perrild, S. Andersen, I. B. Pedersen, and A. Carle. 2010. Iodine intake as a determinant of thyroid disorders in populations. Best Practice & Research. Clinical Endocrinology & Metabolism 24 (1):13–27. doi: 10.1016/j.beem.2009.08.013.
  • Lavado-Autric, R., E. Ausó, J. V. García-Velasco, M. d C. Arufe, F. Escobar del Rey, P. Berbel, and G. Morreale de Escobar. 2003. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. The Journal of Clinical Investigation 111 (7):1073–82. doi: 10.1172/JCI16262.
  • Leung, A. M., and L. E. Braverman. 2012. Iodine-induced thyroid dysfunction. Current Opinion in Endocrinology, Diabetes and Obesity 19 (5):414–9. doi: 10.1097/MED.0b013e3283565bb2.
  • Leung, A. M., and L. E. Braverman. 2014. Consequences of excess iodine. Nature Reviews. Endocrinology 10 (3):136–42. doi: 10.1038/nrendo.2013.251.
  • Levie, D., T. I. M. Korevaar, S. C. Bath, A. Dalmau-Bueno, M. Murcia, M. Espada, M. Dineva, J. M. Ibarluzea, J. Sunyer, H. Tiemeier, et al. 2018. Thyroid function in early pregnancy, child IQ, and autistic traits: A meta-analysis of individual participant data. The Journal of Clinical Endocrinology & Metabolism 103 (8):2967–79. doi: 10.1210/jc.2018-00224.
  • Li, H., S. Chen, L. Wu, H. Wang, K. Xiao, Y. Gao, Y. Li, H. Li, B. Xiao, and Y. Zhu. 2019. The effects of perineal disinfection on infant's oral microflora after transvaginal examination during delivery. BMC Pregnancy and Childbirth 19 (1):213. doi: 10.1186/s12884-019-2350-3.
  • Li, H. P., R. Brinkmeyer, W. L. Jones, S. Zhang, C. Xu, K. A. Schwehr, P. H. Santschi, D. I. Kaplan, and C. M. Yeager. 2011. Iodide accumulation by aerobic bacteria isolated from subsurface sediments of a 129I-contaminated aquifer at the Savannah River Site, South Carolina. Applied and Environmental Microbiology 77 (6):2153–60. doi: 10.1128/AEM.02164-10.
  • López-Muñoz, E., L. Mateos-Sánchez, G. E. Mejía-Terrazas, and S. E. Bedwell-Cordero. 2019. Hypothyroidism and isolated hypothyroxinemia in pregnancy, from physiology to the clinic. Taiwanese Journal of Obstetrics & Gynecology 58 (6):757–763. doi: 10.1016/j.tjog.2019.09.005.
  • Luo, Y., A. Kawashima, Y. Ishido, A. Yoshihara, K. Oda, N. Hiroi, T. Ito, N. Ishii, and K. Suzuki. 2014. Iodine excess as an environmental risk factor for autoimmune thyroid disease. International Journal of Molecular Sciences 15 (7):12895–912. doi: 10.3390/ijms150712895.
  • Maalouf, J., J. Barron, J. P. Gunn, K. Yuan, C. G. Perrine, and M. E. Cogswell. 2015. Iodized salt sales in the United States. Nutrients 7 (3):1691–95. doi: 10.3390/nu7031691.
  • Manousou, S., L. Dahl, B. H. Thuesen, L. Hulthen, and H. N. Filipsson. 2017. Iodine deficiency and nutrition in Scandinavia. Minerva Medica 108 (2):147–58. doi: 10.23736/S0026-4806.16.04849-7.
  • Mansourian, A. R. 2011. Metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland: A review of articles. Pakistan Journal of Biological Sciences 14 (1):1–12. http://www.ncbi.nlm.nih.gov/pubmed/21913492. doi: 10.3923/pjbs.2011.1.12.
  • Marini, H., F. Polito, E. B. Adamo, A. Bitto, F. Squadrito, and S. Benvenga. 2012. Update on genistein and thyroid: An overall message of safety. Frontiers in Endocrinology 3:94. doi: 10.3389/fendo.2012.00094.
  • Maris, P. 1995. Modes of action of disinfectants. Revue Scientifique et Technique 14 (1):47–55. doi: 10.20506/rst.14.1.829.
  • Marwaha, R. K., N. Tandon, M. K. Garg, A. Desai, R. Kanwar, A. Sastry, A. Narang, S. Arora, and K. Bhadra. 2012. Thyroid status two decades after salt iodization: Country-wide data in school children from India. Clinical Endocrinology 76 (6):905–10. doi: 10.1111/j.1365-2265.2011.04307.x.
  • McDonnell, G., and A. D. Russell. 1999. Antiseptics and disinfectants: Activity, action, and resistance. Clinical Microbiology Reviews 12 (1):147–79. http://www.ncbi.nlm.nih.gov/pubmed/9880479.
  • Medicine, Institute of Iodine. 2001. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press. 10.17226/10026
  • Rousset, B., C. Dupuy, F. Miot, J. Dumont. 2015. Chapter 2 Thyroid hormone synthesis and secretion. In Endotext, ed. L. J. De Groot, G. Chrousos, K. Dungan, K. R. Feingold, A. Grossman, J. M. Hershman, C. Koch, et al. South Dartmouth, MA: MDText.com, Inc. http://www.ncbi.nlm.nih.gov/pubmed/25905405.
  • Młyniec, K., M. Gaweł, U. Doboszewska, G. Starowicz, K. Pytka, C. L. Davies, and B. Budziszewska. 2015. Essential elements in depression and anxiety. Part II. Pharmacological Reports 67 (2):187–94. doi: 10.1016/j.pharep.2014.09.009.
  • Moleti, M., V. P. Lo Presti, M. C. Campolo, F. Mattina, M. Galletti, M. Mandolfino, M. A. Violi, G. Giorgianni, D. De Domenico, F. Trimarchi, et al. 2008. Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency. The Journal of Clinical Endocrinology & Metabolism 93 (7):2616–21. doi: 10.1210/jc.2008-0352.
  • Moleti, M., F. Trimarchi, G. Tortorella, A. Candia Longo, G. Giorgianni, G. Sturniolo, A. Alibrandi, and F. Vermiglio. 2016. Effects of maternal iodine nutrition and thyroid status on cognitive development in offspring: A pilot study. Thyroid 26 (2):296–305. doi: 10.1089/thy.2015.0336.
  • Moleti, M., F. Trimarchi, and F. Vermiglio. 2011. Doubts and concerns about isolated maternal hypothyroxinemia. Journal of Thyroid Research 2011:463029. doi: 10.4061/2011/463029.
  • Mondal, S., K. Raja, U. Schweizer, and G. Mugesh. 2016. Chemistry and biology in the biosynthesis and action of thyroid hormones. Angewandte Chemie 55 (27):7606–30. doi: 10.1002/anie.201601116.
  • Moreno, J. C., and T. J. Visser. 2007. New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations. Endocrine Development 10:99–117. doi:10.1159/000106822. PMID17684392
  • Mullur, R., Y. Y. Liu, and G. A. Brent. 2014. Thyroid hormone regulation of metabolism. Physiological Reviews 94 (2):355–82. doi: 10.1152/physrev.00030.2013.
  • Murcia, M., M. Espada, J. Julvez, S. Llop, M.-J. Lopez-Espinosa, J. Vioque, M. Basterrechea, I. Riaño, L. González, M. Alvarez-Pedrerol, et al. 2018. Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: The INMA mother and child cohort study. Journal of Epidemiology and Community Health 72 (3):216–222. doi: 10.1136/jech-2017-209830.
  • Murray, C. W., S. K. Egan, H. Kim, N. Beru, and P. M. Bolger. 2008. US Food and Drug Administration’s Total diet study: Dietary intake of perchlorate and iodine. Journal of Exposure Science & Environmental Epidemiology 18 (6):571–80. doi: 10.1038/sj.jes.7500648.
  • Negro, R., O. P. Soldin, M. J. Obregon, and A. Stagnaro-Green. 2011. Hypothyroxinemia and pregnancy. Endocrine Practice 17 (3):422–29. doi: 10.4158/EP10309.RA.
  • Nicola, J. P., C. Basquin, C. Portulano, A. Reyna-Neyra, M. Paroder, and N. Carrasco. 2009. The Na+/I- symporter mediates active iodide uptake in the intestine. American Journal of Physiology. Cell Physiology 296 (4):C654–62. doi: 10.1152/ajpcell.00509.2008.
  • Nicola, J. P., M. Nazar, I. D. Mascanfroni, C. G. Pellizas, and A. M. Masini-Repiso. 2010. NF-KappaB P65 subunit mediates lipopolysaccharide-induced Na(+)/I(-) symporter gene expression by involving functional interaction with the paired domain transcription factor Pax8. Molecular Endocrinology 24 (9):1846–62. doi: 10.1210/me.2010-0102.
  • Niwattisaiwong, S., K. D. Burman, and M. Li-Ng. 2017. Iodine deficiency: Clinical implications. Cleveland Clinic Journal of Medicine 84 (3):236–44. doi: 10.3949/ccjm.84a.15053.
  • O’Donnell, K. J., M. A. Rakeman, D. Zhi-Hong, C. Xue-Yi, Z. Y. Mei, N. DeLong, G. Brenner, M. Tai, W. Dong, and G. R. DeLong. 2002. Effects of iodine supplementation during pregnancy on child growth and development at school age. Developmental Medicine and Child Neurology 44 (2):76–81. doi: 10.1017/s0012162201001712.
  • Olivieri, A., C. D. I. Cosmo, S. D. E. Angelis, R. D. A. Cas, P. Stacchini, A. Pastorelli, P. Vitti, and Prevention Regional Observatories for Goiter. 2017. The way forward in Italy for iodine. Minerva Medica 108 (2):159–68. doi: 10.23736/S0026-4806.17.04877-7.
  • Opazo, M. C., A. Gianini, F. Pancetti, G. Azkcona, L. Alarcón, R. Lizana, V. Noches, P. A. Gonzalez, M. P. Marassi, M. Porto, et al. 2008. Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring. Endocrinology 149 (10):5097–5106. doi: 10.1210/en.2008-0560.
  • Opazo, M. C., P. A. Gonzalez, B. D. Flores, L. F. Venegas, E. A. Albornoz, P. Cisternas, K. Bohmwald, P. A. Nieto, S. M. Bueno, A. M. Kalergis, et al. 2017. Gestational hypothyroxinemia imprints a switch in the capacity of astrocytes and microglial cells of the offspring to react in inflammation. Molecular Neurobiology 55 (5):4373–4387. doi: 10.1007/s12035-017-0627-y.
  • Opazo, M. C., H. Haensgen, K. Bohmwald, L. F. Venegas, H. Boudin, A. A. Elorza, F. Simon, C. Fardella, S. M. Bueno, A. M. Kalergis, et al. 2017. Imprinting of maternal thyroid hormones in the offspring. International Reviews of Immunology 36 (4):240–55. doi: 10.1080/08830185.2016.1277216.
  • Palaniappan, S., L. Shanmughavelu, H. K. Prasad, S. Subramaniam, N. Krishnamoorthy, and L. Lakkappa. 2017. Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children. Indian Journal of Endocrinology and Metabolism 21 (1):85–89. doi: 10.4103/2230-8210.195996.
  • Patel, J., K. Landers, H. Li, R. H. Mortimer, and K. Richard. 2011. Delivery of maternal thyroid hormones to the fetus. Trends in Endocrinology and Metabolism: TEM 22 (5):164–70. doi: 10.1016/j.tem.2011.02.002.
  • Patrick, L. 2008. Iodine: Deficiency and therapeutic considerations. Alternative Medicine Review 13 (2):116–27. http://www.ncbi.nlm.nih.gov/pubmed/18590348.
  • Pearce, E. N., J. H. Lazarus, R. Moreno-Reyes, and M. B. Zimmermann. 2016. Consequences of iodine deficiency and excess in pregnant women: An overview of current knowns and unknowns. The American Journal of Clinical Nutrition 104 (suppl_3):918S–923S. doi: 10.3945/ajcn.115.110429.
  • Pearce, E. N., S. Pino, X. He, H. R. Bazrafshan, S. L. Lee, and L. E. Braverman. 2004. Sources of dietary iodine: Bread, cows' milk, and infant formula in the Boston area. The Journal of Clinical Endocrinology and Metabolism 89 (7):3421–24. doi: 10.1210/jc.2003-032002.
  • Peeters, R. P. 2017. Subclinical hypothyroidism. The New England Journal of Medicine 376 (26):2556–65. doi: 10.1056/NEJMcp1611144.
  • Pharoah, P. O. D., I. H. Buttfield, and B. S. Hetzel. 1971. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. The Lancet 297 (7694):308–10. doi: 10.1016/S0140-6736(71)91040-3.
  • Portulano, C., M. Paroder-Belenitsky, and N. Carrasco. 2014. The Na+/I- symporter (NIS): Mechanism and medical impact. Endocrine Reviews 35 (1):106–49. doi: 10.1210/er.2012-1036.
  • Ragusa, F., P. Fallahi, G. Elia, D. Gonnella, S. R. Paparo, C. Giusti, L. P. Churilov, S. M. Ferrari, and A. Antonelli. 2019. Hashimotos’ thyroiditis: Epidemiology, pathogenesis, clinic and therapy. Best Practice and Research: Clinical Endocrinology and Metabolism 33 (6):101367. 10.1016/j.beem.2019.101367.
  • Ravera, S., A. Reyna-Neyra, G. Ferrandino, L. M. Amzel, and N. Carrasco. 2017. The sodium/iodide symporter (NIS): Molecular physiology and preclinical and clinical applications. Annual Review of Physiology 79:261–89. doi: 10.1146/annurev-physiol-022516-034125.
  • Rayman, M. P. 2012. Selenium and human health. The Lancet 379 (9822):1256–68. doi: 10.1016/S0140-6736(11)61452-9.
  • Redman, K., T. Ruffman, P. Fitzgerald, and S. Skeaff. 2016. Iodine deficiency and the brain: Effects and mechanisms. Critical Reviews in Food Science and Nutrition 56 (16):2695–713. doi: 10.1080/10408398.2014.922042.
  • Riesco-Eizaguirre, G., L. Wert-Lamas, J. Perales-Paton, A. Sastre-Perona, L. P. Fernandez, and P. Santisteban. 2015. The MiR-146b-3p/PAX8/NIS regulatory circuit modulates the differentiation phenotype and function of thyroid cells during carcinogenesis. Cancer Research 75 (19):4119–30. doi: 10.1158/0008-5472.CAN-14-3547.
  • Ris-Stalpers, C., and H. Bikker. 2010. Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. Molecular and Cellular Endocrinology 322 (1-2):38–43. doi: 10.1016/j.mce.2010.02.008.
  • Rodondi, N., A. B. Newman, E. Vittinghoff, N. de Rekeneire, S. Satterfield, T. B. Harris, and D. C. Bauer. 2005. Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Archives of Internal Medicine 165 (21):2460–66. doi: 10.1001/archinte.165.21.2460.
  • Rohner, F., M. Zimmermann, P. Jooste, C. Pandav, K. Caldwell, R. Raghavan, and D. J. Raiten. 2014. Biomarkers of nutrition for development-iodine review. The Journal of Nutrition 144 (8):1322S–42S. doi: 10.3945/jn.113.181974.
  • Román, G. C. 2007. Autism: Transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. Journal of the Neurological Sciences 262 (1-2):15–26. doi: 10.1016/j.jns.2007.06.023.
  • Román, G. C., A. Ghassabian, J. J. Bongers‐Schokking, V. W. V. Jaddoe, A. Hofman, Y. B. Rijke, F. C. Verhulst, and H. Tiemeier. 2013. Association of gestational maternal hypothyroxinemia and increased autism risk. Annals of Neurology 74 (5):733–42. doi: 10.1002/ana.23976.
  • Sarah Davis, O., S. Margaret, M. B. Jennifer, and B. Betty. 2012. Use of iodized salt in processed foods in select countries around the world and the role of food processors. Comprehensive Reviews in Food Science and Food Safety 11 (2):233–84. doi: 10.1111/j.1541-4337.2011.00182.x.
  • Schmutzler, C., I. Gotthardt, P. J. Hofmann, B. Radovic, G. Kovacs, L. Stemmler, I. Nobis, A. Bacinski, B. Mentrup, P. Ambrugger, et al. 2007. Endocrine disruptors and the thyroid gland—A combined in vitro and in vivo analysis of potential new biomarkers. Environmental Health Perspectives 115 (Suppl 1):77–83. doi: 10.1289/ehp.9369.
  • Schomburg, L, and J. Köhrle. 2008. On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. Molecular Nutrition & Food Research 52 (11):1235–46. doi:10.1002/mnfr.200700465. PMID: 18686295
  • Schug, T. T., R. Abagyan, B. Blumberg, T. J. Collins, D. Crews, P. L. DeFur, S. M. Dickerson, T. M. Edwards, A. C. Gore, L. J. Guillette, et al. 2013. Designing endocrine disruption out of the next generation of chemicals. Green Chemistry 15 (1):181–98. doi: 10.1039/C2GC35055F.
  • Seo, G. H., and J. H. Chung. 2015. Incidence and prevalence of overt hypothyroidism and causative diseases in Korea as determined using claims data provided by the health insurance review and assessment service. Endocrinology and Metabolism 30 (3):288–96. doi: 10.3803/EnM.2015.30.3.288.
  • Shen, H., J. Han, Y. Li, C. Lu, J. Zhou, Y. Li, and X. Su. 2019. Different host-specific responses in thyroid function and gut microbiota modulation between diet-induced obese and normal mice given the same dose of iodine. Applied Microbiology and Biotechnology 103 (8):3537–47. doi: 10.1007/s00253-019-09687-1.
  • Shirai, J., T. Kanno, Y. Tsuchiya, S. Mitsubayashi, and R. Seki. 2000. Effects of chlorine, iodine, and quaternary ammonium compound disinfectants on several exotic disease viruses. The Journal of Veterinary Medical Science 62 (1):85–92. doi: 10.1292/jvms.62.85.
  • Siffo, S., E. Adrover, C. E. Citterio, M. B. Miras, V. A. Balbi, A. Chiesa, J. Weill, G. Sobrero, V. G. González, P. Papendieck, et al. 2018. Molecular analysis of thyroglobulin mutations found in patients with goiter and hypothyroidism. Molecular and Cellular Endocrinology 473:1–16. doi: 10.1016/j.mce.2017.12.009.
  • Silbereis, J. C., S. Pochareddy, Y. Zhu, M. Li, and N. Sestan. 2016. The cellular and molecular landscapes of the developing human central nervous system. Neuron 89 (2):248–268. doi: 10.1016/j.neuron.2015.12.008.
  • Simmons, S. R., and M. L. Karnovsky. 1973. Iodinating ability of various leukocytes and their bactericidal activity. The Journal of Experimental Medicine 138 (1):44–63. doi: 10.1084/jem.138.1.44.
  • Sirakov, M., and M. Plateroti. 2011. The thyroid hormones and their nuclear receptors in the gut: From developmental biology to cancer. Biochim Biophys Acta 1812(8):938–46. doi: 10.1016/j.bbadis.2010.12.020. PMID: 21194566.
  • Sriwilaijaroen, N., P. Wilairat, H. Hiramatsu, T. Takahashi, T. Suzuki, M. Ito, Y. Ito, M. Tashiro, and Y. Suzuki. 2009. Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: Its effects on hemagglutination and sialidase activities. Virology Journal 6:124. doi: 10.1186/1743-422X-6-124.
  • Stiles, J., and T. L. Jernigan. 2010. The basics of brain development. Neuropsychology Review 20 (4):327–48. doi: 10.1007/s11065-010-9148-4.
  • Sun, X., Z. Shan, and W. Teng. 2014. Effects of increased iodine intake on thyroid disorders. Endocrinology and Metabolism 29 (3):240–47. doi: 10.3803/EnM.2014.29.3.240.
  • Taylor, P. N., D. Albrecht, A. Scholz, G. Gutierrez-Buey, J. H. Lazarus, C. M. Dayan, and O. E. Okosieme. 2018. Global epidemiology of hyperthyroidism and hypothyroidism. Nature Reviews. Endocrinology 14 (5):301–16. doi: 10.1038/nrendo.2018.18.
  • Taylor, R. M., S. M. Fealy, A. Bisquera, R. Smith, C. E. Collins, T. J. Evans, and A. J. Hure. 2017. Effects of nutritional interventions during pregnancy on infant and child cognitive outcomes: A systematic review and meta-analysis. Nutrients 9 (11):1265. 10.3390/nu9111265.
  • Teas, J., S. Pino, A. Critchley, and L. E. Braverman. 2004. Variability of iodine content in common commercially available edible seaweeds. Thyroid 14 (10):836–41. doi: 10.1089/thy.2004.14.836.
  • Thompson, W., G. Russell, G. Baragwanath, J. Matthews, B. Vaidya, and J. Thompson-Coon. 2018. Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis. Clinical Endocrinology 88 (4):575–84. doi: 10.1111/cen.13550.
  • Valeix, P., P. Faure, S. Peneau, C. Estaquio, S. Hercberg, and S. Bertrais. 2009. Lifestyle factors related to iodine intakes in French adults. Public Health Nutrition 12 (12):2428–37. doi: 10.1017/S1368980009005515.
  • Vanderpump, M. P. 2011. The epidemiology of thyroid disease. British Medical Bulletin 99:39–51. doi: 10.1093/bmb/ldr030.
  • Verheesen, R. H., and C. M. Schweitzer. 2008. Iodine deficiency, more than cretinism and goiter. Medical Hypotheses 71 (5):645–48. doi: 10.1016/j.mehy.2008.06.020.
  • Vermiglio, F., V. P. Lo Presti, M. Moleti, M. Sidoti, G. Tortorella, G. Scaffidi, M. G. Castagna, F. Mattina, M. A. Violi, A. Crisà, et al. 2004. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. The Journal of Clinical Endocrinology and Metabolism 89 (12):6054–60. doi: 10.1210/jc.2004-0571.
  • Virili, C., and M. Centanni. 2017. “With a little help from my friends”—The role of microbiota in thyroid hormone metabolism and enterohepatic recycling. Molecular and Cellular Endocrinology 458:39–43. doi: 10.1016/j.mce.2017.01.053.
  • Visser, W. E., E. C. H. Friesema, and T. J. Visser. 2011. Minireview: Thyroid hormone transporters: The knowns and the unknowns. Molecular Endocrinology 25 (1):1–14. doi: 10.1210/me.2010-0095.
  • Vought, R. L., F. A. Brown, K. H. Sibinovic, and E. G. McDaniel. 1972. Effect of changing intestinal bacterial flora on thyroid function in the rat. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme 4 (1):43–47. doi: 10.1055/s-0028-1094095.
  • Walker, S. P., T. D. Wachs, J. M. Gardner, B. Lozoff, G. A. Wasserman, E. Pollitt, J. A. Carter, and Group International Child Development Steering. 2007. Child development: Risk factors for adverse outcomes in developing countries. Lancet 369 (9556):145–57. doi: 10.1016/S0140-6736. (07)60076-2.
  • Wang, K., Y. N. Sun, J. Y. Liu, L. Zhang, Y. Ye, L. X. Lin, Y. Q. Yan, and Z. P. Chen. 2009. The impact of iodine excess on thyroid hormone biosynthesis and metabolism in rats. Biological Trace Element Research 130 (1):72–85. doi: 10.1007/s12011-009-8315-z.
  • Weiss, R. V., and R. Clapauch. 2014. Female infertility of endocrine origin. Arquivos Brasileiros de Endocrinologia & Metabologia 58 (2):144–52. http://www.ncbi.nlm.nih.gov/pubmed/24830591.
  • Weng, H. X., J. K. Weng, W. B. Yong, X. W. Sun, and H. Zhong. 2003. Capacity and degree of iodine absorbed and enriched by vegetable from soil. Journal of Environmental Sciences 15 (1):107–11. http://www.ncbi.nlm.nih.gov/pubmed/12602613.
  • Whitehead, D. C. 1984. The distribution and transformation of iodine in the enviroment. Enviroment International 10 (4):321–39. doi: 10.1016/0160-4120(84)90139-9.
  • WHO. 2004. Iodine status worldwide: WHO Global Database on Iodine De Ciency. Geneva.
  • WHO. 2008. WHO, UNICEF and ICCIDD. Assessment of the iodine deficiency disorders and monitoring their elimination. http://www.who.int/nutrition/publications/micronutrients/iodine_deficiency/9789241595827/en/.
  • Zbigniew, S. 2017. Role of iodine in metabolism. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 10 (2):123–26. doi: 10.2174/1872214811666170119110618.
  • Zealand, Food Standards Australia New. 2015. Iodine in food and iodine requirements. http://www.foodstandards.gov.au/consumer/nutrition/iodinefood/Pages/default.aspx.
  • Zhao, F., J. Feng, J. Li, L. Zhao, Y. Liu, H. Chen, Y. Jin, B. Zhu, and Y. Wei. 2018. Alterations of the gut microbiota in Hashimoto’s thyroiditis patients. Thyroid 28 (2):175–86.
  • Zhou, L., X. Li, A. Ahmed, D. Wu, L. Liu, J. Qiu, Y. Yan, M. Jin, and Y. Xin. 2014. Gut microbe analysis between hyperthyroid and healthy individuals. Current Microbiology 69 (5):675–80. doi: 10.1007/s00284-014-0640-6.
  • Zhou, S. J., S. A. Skeaff, P. Ryan, L. W. Doyle, P. J. Anderson, L. Kornman, A. J. McPhee, L. N. Yelland, and M. Makrides. 2015. The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: Results of an aborted randomised placebo-controlled trial. Trials 16:563. doi: 10.1186/s13063-015-1080-8.
  • Zhu, Y. G., Y. Z. Huang, Y. Hu, and Y. X. Liu. 2003. Iodine uptake by spinach (Spinacia oleracea L.) plants grown in solution culture: Effects of iodine species and solution concentrations. Environment International 29 (1):33–37. doi: 10.1016/S0160-4120(02)00129-0.
  • Zimmermann, M. B., P. L. Jooste, and C. S. Pandav. 2008. Iodine-deficiency disorders. Lancet 372 (9645):1251–62. doi: 10.1016/S0140-6736(08)61005-3.
  • Zoltowska, D., Y. Agrawal, S. Patri, S. Aggarwal, C. S. Reddy, N. Sareen, J. Kalavakunta, and V. Gupta. 2018. Association between hypothyroidism and Takotsubo cardiomyopathy: Analysis of nationwide inpatient sample database. Reviews on Recent Clinical Trials 13 (3):222–5. doi: 10.2174/1574887113666180402144600.

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