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Effectiveness of nanoscale delivery systems on improving the bioavailability of lutein in rodent models: a systematic review

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References

  • Anton, N., J. P. Benoit, and P. Saulnier. 2008. Design and production of nanoparticles formulated from nano-emulsion templates—A review. Journal of Controlled Release 128 (3):185–99. doi: 10.1016/j.jconrel.2008.02.007.
  • Arunkumar, R., K. V. H. Prashanth, and V. Baskaran. 2013. Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: Characterization and bioavailability of lutein in vitro and in vivo. Food Chemistry 141 (1):327–37. doi: 10.1016/j.foodchem.2013.02.108.
  • Arunkumar, R., K. V. H. Prashanth, Y. Manabe, T. Hirata, T. Sugawara, S. M. Dharmesh, and V. Baskaran. 2015. Biodegradable poly (lactic-co-glycolic acid)-polyethylene glycol nanocapsules: An efficient carrier for improved solubility, bioavailability, and anticancer property of lutein. Journal of Pharmaceutical Sciences 104 (6):2085–93. doi: 10.1002/jps.24436.
  • Bergin, I. L., and F. A. Witzmann. 2013. Nanoparticle toxicity by the gastrointestinal route: Evidence and knowledge gaps. International Journal of Biomedical Nanoscience and Nanotechnology 3 (1/2):163–210. doi: 10.1504/IJBNN.2013.054515.
  • Bhat, I., U. G. Yathisha, I. Karunasagar, and B. S. Mamatha. 2020. Nutraceutical approach to enhance lutein bioavailability via nanodelivery systems. Nutrition Reviews 78 (9):709–24. doi: 10.1093/nutrit/nuz096.
  • Bone, R. A., J. T. Landrum, L. H. Guerra, and C. A. Ruiz. 2003. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. The Journal of Nutrition 133 (4):992–8. doi: 10.1093/jn/133.4.992.
  • Casettari, L., and L. Illum. 2014. Chitosan in nasal delivery systems for therapeutic drugs. Journal of Controlled Release 190:189–200. doi: 10.1016/j.jconrel.2014.05.003.
  • Chan, L. W., H. Y. Lee, and P. W. S. Heng. 2002. Production of alginate microspheres by internal gelation using an emulsification method. International Journal of Pharmaceutics 242 (1-2):259–62. doi: 10.1016/S0378-5173(02)00170-9.
  • Chang, D., Y. Ma, G. Cao, J. Wang, X. Zhang, J. Feng, and W. Wang. 2018. Improved oral bioavailability for lutein by nanocrystal technology: Formulation development, in vitro and in vivo evaluation. Artificial Cells, Nanomedicine, and Biotechnology 46 (5):1018–24. doi: 10.1080/21691401.2017.1358732.
  • Chung, C., G. Smith, B. Degner, and D. J. McClements. 2016. Reduced fat food emulsions: Physicochemical, sensory, and biological aspects. Critical Reviews in Food Science and Nutrition 56 (4):650–85. doi: 10.1080/10408398.2013.792236.
  • Connolly, E. E., S. Beatty, D. I. Thurnham, J. Loughman, A. N. Howard, J. Stack, and J. M. Nolan. 2010. Augmentation of macular pigment following supplementation with all three macular carotenoids: An exploratory study. Current Eye Research 35 (4):335–51. doi: 10.3109/02713680903521951.
  • do Prado Silva, J. T., J. M. T. Geiss, S. M. Oliveira, E. D. S. Brum, S. C. Sagae, D. Becker, F. V. Leimann, R. P. Ineu, G. P. Guerra, and O. H. Gonçalves. 2017. Nanoencapsulation of lutein and its effect on mice's declarative memory. Materials Science & Engineering. C, Materials for Biological Applications 76:1005–11. doi: 10.1016/j.msec.2017.03.212.
  • Elieh-Ali-Komi, D., and M. R. Hamblin. 2016. Chitin and chitosan: Production and application of versatile biomedical nanomaterials. International Journal of Advanced Research 4 (3):411–27.
  • Focsan, A. L., N. E. Polyakov, and L. D. Kispert. 2019. Supramolecular carotenoid complexes of enhanced solubility and stability—The way of bioavailability improvement. Molecules 24 (21):3947. doi: 10.3390/molecules24213947.
  • Friedman, A. J., J. Phan, D. O. Schairer, J. Champer, M. Qin, A. Pirouz, K. Blecher-Paz, A. Oren, P. T. Liu, R. L. Modlin, et al. 2013. Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: A targeted therapy for cutaneous pathogens. The Journal of Investigative Dermatology 133 (5):1231–9. doi: 10.1038/jid.2012.399.
  • Gentile, P., V. Chiono, I. Carmagnola, and P. V. Hatton. 2014. An overview of poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering. International Journal of Molecular Sciences 15 (3):3640–59. doi: 10.3390/ijms15033640.
  • Gidal, B. E., A. M. Clark, B. Anders, and F. Gilliam. 2017. The application of half-life in clinical decision making: Comparison of the pharmacokinetics of extended-release topiramate (USL255) and immediate-release topiramate. Epilepsy Research 129:26–32. doi: 10.1016/j.eplepsyres.2016.10.020.
  • Henderson, P. T., and C.-X. Pan. 2010. Human microdosing for the prediction of patient response. Bioanalysis 2 (3):373–6. doi: 10.4155/bio.10.3.
  • Hooijmans, C. R., M. M. Rovers, R. B. M. de Vries, M. Leenaars, M. Ritskes-Hoitinga, and M. W. Langendam. 2014. SYRCLE’s risk of bias tool for animal studies. BMC Medical Research Methodology 14:43. doi: 10.1186/1471-2288-14-43.
  • House, W. A., J. Apgar, and J. C. Smith. 1997. The gerbil: A model for studying the metabolism of beta-carotene and minerals. Nutrition Research 17 (8):1293–302. doi: 10.1016/S0271-5317(97)00113-9.
  • Itagaki, S., W. Ogura, Y. Sato, T. Noda, T. Hirano, S. Mizuno, and K. Iseki. 2006. Characterization of the disposition of lutein after i.v. Administration to rats. Biological & Pharmaceutical Bulletin 29 (10):2123–5. doi: 10.1248/bpb.29.2123.
  • Jaiswal, M., R. Dudhe, and P. K. Sharma. 2015. Nanoemulsion: An advanced mode of drug delivery system. 3 Biotech 5 (2):123–7. doi: 10.1007/s13205-014-0214-0.
  • Jiang, X-y, L-s Chen, and C-s Zhou. 2005. Lutein and lutein esters in marigold flowers by high performance chromatography. Journal of Central South University of Technology 12 (3):306–8. doi: 10.1007/s11771-005-0150-6.
  • Johnson, E. J., B. R. Hammond, K.-J. Yeum, J. Qin, X. D. Wang, C. Castaneda, D. M. Snodderly, and R. M. Russell. 2000. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. The American Journal of Clinical Nutrition 71 (6):1555–62. doi: 10.1093/ajcn/71.6.1555.
  • Kamil, A., D. E. Smith, J. B. Blumberg, C. Astete, C. Sabliov, and C. Y. Oliver Chen. 2016. Bioavailability and biodistribution of nanodelivered lutein. Food Chemistry 192:915–23. doi: 10.1016/j.foodchem.2015.07.106.
  • Khan, S., J. S. Boateng, J. Mitchell, and V. Trivedi. 2015. Formulation, characterisation and stabilisation of buccal films for paediatric drug delivery of omeprazole. AAPS PharmSciTech 16 (4):800–10. doi: 10.1208/s12249-014-0268-7.
  • Kopec, R. E., B. Gleize, P. Borel, C. Desmarchelier, and C. Caris-Veyrat. 2017. Are lutein, lycopene, and β-carotene lost through the digestive process? Food & Function 8 (4):1494–503. doi: 10.1039/c7fo00021a.
  • Landrum, J. T., and R. A. Bone. 2001. Lutein, zeaxanthin, and the macular pigment. Archives of Biochemistry and Biophysics 385 (1):28–40. doi: 10.1006/abbi.2000.2171.
  • Lee, C. M., A. C. Boileau, T. W. M. Boileau, A. W. Williams, K. S. Swanson, K. A. Heintz, and J. W. Erdman, Jr. 1999. Review of animal models in carotenoid research. The Journal of Nutrition 129 (12):2271–7. doi: 10.1093/jn/129.12.2271.
  • Lee, C. M., J. D. Lederman, N. E. Hofmann, and J. W. Erdman. 1998. The mongolian gerbil (Meriones unguiculatus) is an appropriate animal model for evaluation of the conversion of beta-carotene to vitamin A. The Journal of Nutrition 128 (2):280–6. doi: 10.1093/jn/128.2.280.
  • Li, B., P. P. Vachali, Z. Shen, A. Gorusupudi, K. Nelson, B. M. Besch, A. Bartschi, S. Longo, T. Mattinson, S. Shihab, et al. 2017. Retinal accumulation of zeaxanthin, lutein, and β-carotene in mice deficient in carotenoid cleavage enzymes. Experimental Eye Research 159:123–31. doi: 10.1016/j.exer.2017.02.016.
  • Lieblein-Boff, J. C., E. J. Johnson, A. D. Kennedy, C.-S. Lai, and M. J. Kuchan. 2015. Exploratory metabolomic analyses reveal compounds correlated with lutein concentration in frontal cortex, hippocampus, and occipital cortex of human infant brain. PLoS One 10 (8):e0136904. doi: 10.1371/journal.pone.0136904.
  • Lienau, A., T. Glaser, G. Tang, G. G. Dolnikowski, M. A. Grusak, and K. Albert. 2003. Bioavailability of lutein in humans from intrinsically labeled vegetables determined by LC-APCI-MS. The Journal of Nutritional Biochemistry 14 (11):663–70. doi: 10.1016/j.jnutbio.2003.08.004.
  • Liu, C., D. Chang, X. Zhang, H. Sui, Y. Kong, R. Zhu, and W. Wang. 2017. Oral fast-dissolving films containing lutein nanocrystals for improved bioavailability: Formulation development, in vitro and in vivo evaluation. AAPS PharmSciTech 18 (8):2957–64. doi: 10.1208/s12249-017-0777-2.
  • Liu, R., T. Wang, B. Zhang, L. Qin, C. Wu, Q. Li, and L. Ma. 2015. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Investigative Ophthalmology & Visual Science 56 (1):252–8. doi: 10.1167/iovs.14-15553.
  • Mardani, R., M. R. Hamblin, M. Taghizadeh, H. R. Banafshe, M. Nejati, M. Mokhtari, S. Borran, A. Davoodvandi, H. Khan, M. R. Jaafari, et al. 2020. Nanomicellar-curcumin exerts its therapeutic effects via affecting angiogenesis, apoptosis, and T cells in a mouse model of melanoma lung metastasis. Pathology, Research and Practice 216 (9):153082. doi: 10.1016/j.prp.2020.153082.
  • McClements, D. J. 2015. Nanoscale nutrient delivery systems for food applications: Improving bioactive dispersibility, stability, and bioavailability. Journal of Food Science 80 (7):N1602–11. doi: 10.1111/1750-3841.12919.
  • Medhe, S., P. Bansal, and M. M. Srivastava. 2014. Enhanced antioxidant activity of gold nanoparticle embedded 3,6-dihydroxyflavone: A combinational study. Applied Nanoscience 4 (2):153–61. doi: 10.1007/s13204-012-0182-9.
  • Mishra, S. B., J. Malaviya, and A. Mukerjee. 2015. Attenuation of oxidative stress and glucose toxicity by lutein loaded nanoparticles from Spinacia oleracea leaves. Journal of Pharmaceutical Sciences and Pharmacology 2 (3):242–9. doi: 10.1166/jpsp.2015.1067.
  • Moher, D., A. Liberati, J. Tetzlaff, D. G. Altman, and Prisma Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine 6 (7):e1000097. doi: 10.1371/journal.pmed.1000097.
  • Muriach, M., F. Bosch-Morell, E. Arnal, G. Alexander, R. Blomhoff, and F. J. Romero. 2008. Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitro. Journal of Physiology and Biochemistry 64 (2):149–57. doi: 10.1007/bf03168243.
  • Murillo, A. G., D. Aguilar, G. H. Norris, D. M. DiMarco, A. Missimer, S. Hu, J. A. Smyth, S. Gannon, C. N. Blesso, Y. Luo, et al. 2016. Compared with powdered lutein, a lutein nanoemulsion increases plasma and liver lutein, protects against hepatic steatosis, and affects lipoprotein metabolism in guinea pigs. The Journal of Nutrition 146 (10):1961–9. doi: 10.3945/jn.116.235374.
  • Murugeshu, A., C. Astete, C. Leonardi, T. Morgan, and C. M. Sabliov. 2011. Chitosan/PLGA particles for controlled release of α-tocopherol in the GI tract via oral administration. Nanomedicine 6 (9):1513–28. doi: 10.2217/nnm.11.44.
  • Niamprem, P., S. Rujivipat, and W. Tiyaboonchai. 2014. Development and characterization of lutein-loaded SNEDDS for enhanced absorption in Caco-2 cells. Pharmaceutical Development and Technology 19 (6):735–42. doi: 10.3109/10837450.2013.829092.
  • Nidhi, B., and V. Baskaran. 2013. Acute and subacute toxicity assessment of lutein in lutein-deficient mice. Journal of Food Science 78 (10):T1636–42. doi: 10.1111/1750-3841.12256.
  • Ochoa Becerra, M., L. Mojica Contreras, M. Hsieh Lo, J. Mateos Díaz, and G. Castillo Herrera. 2020. Lutein as a functional food ingredient: Stability and bioavailability. Journal of Functional Foods 66:103771. doi: 10.1016/j.jff.2019.103771.
  • Patra, J. K., G. Das, L. F. Fraceto, E. V. R. Campos, M. D. P. Rodriguez-Torres, L. S. Acosta-Torres, L. A. Diaz-Torres, R. Grillo, M. K. Swamy, S. Sharma, et al. 2018. Nano based drug delivery systems: Recent developments and future prospects. Journal of Nanobiotechnology 16 (1):71. doi: 10.1186/s12951-018-0392-8.
  • Patravale, V. B., A. A. Date, and R. M. Kulkarni. 2004. Nanosuspensions: A promising drug delivery strategy. The Journal of Pharmacy and Pharmacology 56 (7):827–40. doi: 10.1211/0022357023691.
  • Ranganathan, A., R. Hindupur, and B. Vallikannan. 2016. Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice. Materials Science and Engineering: C 69:1318–27. doi: 10.1016/j.msec.2016.08.029.
  • Ranganathan, A., Y. Manabe, T. Sugawara, T. Hirata, N. Shivanna, and V. Baskaran. 2019. Poly (D, L-lactide-co-glycolide)-phospholipid nanocarrier for efficient delivery of macular pigment lutein: Absorption pharmacokinetics in mice and antiproliferative effect in Hep G2 cells. Drug Delivery and Translational Research 9 (1):178–91. doi: 10.1007/s13346-018-0590-9.
  • Rehman, A., Q. Tong, S. M. Jafari, E. Assadpour, Q. Shehzad, R. M. Aadil, M. W. Iqbal, M. M. A. Rashed, B. S. Mushtaq, and W. Ashraf. 2020. Carotenoid-loaded nanocarriers: A comprehensive review. Advances in Colloid and Interface Science 275:102048. doi: 10.1016/j.cis.2019.102048.
  • Ribaya-Mercado, J. D., and J. B. Blumberg. 2004. Lutein and zeaxanthin and their potential roles in disease prevention. Journal of the American College of Nutrition 23 (6 Suppl):567S–87S. doi: 10.1080/07315724.2004.10719427.
  • Sanna, V., A. M. Roggio, S. Siliani, M. Piccinini, S. Marceddu, A. Mariani, and M. Sechi. 2012. Development of novel cationic chitosan-and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol. International Journal of Nanomedicine 7:5501–16. doi: 10.2147/ijn.S36684.
  • Sato, Y., T. Joumura, S. Nashimoto, S. Yokoyama, Y. Takekuma, H. Yoshida, and M. Sugawara. 2018. Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system. European Journal of Pharmaceutics and Biopharmaceutics 127:171–6. doi: 10.1016/j.ejpb.2018.02.013.
  • Sato, Y., R. Suzuki, M. Kobayashi, S. Itagaki, T. Hirano, T. Noda, S. Mizuno, M. Sugawara, and K. Iseki. 2012. Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein. Journal of Pharmacy & Pharmaceutical Sciences 15 (2):256–64. doi: 10.18433/j38k56.
  • Semete, B., L. Booysen, Y. Lemmer, L. Kalombo, L. Katata, J. Verschoor, and H. S. Swai. 2010. In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems. Nanomedicine 6 (5):662–71. doi: 10.1016/j.nano.2010.02.002.
  • Shelar, D. B., S. K. Pawar, and P. R. Vavia. 2013. Fabrication of isradipine nanosuspension by anti-solvent microprecipitation-high-pressure homogenization method for enhancing dissolution rate and oral bioavailability . Drug Delivery and Translational Research 3 (5):384–91. doi: 10.1007/s13346-012-0081-3.
  • Soukoulis, C., and T. Bohn. 2018. A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids. Critical Reviews in Food Science and Nutrition 58 (1):1–36. doi: 10.1080/10408398.2014.971353.
  • Steiner, B. M., D. J. McClements, and G. Davidov-Pardo. 2018. Encapsulation systems for lutein: A review. Trends in Food Science & Technology 82:71–81. doi: 10.1016/j.tifs.2018.10.003.
  • Tan, Q., W. Liu, C. Guo, and G. Zhai. 2011. Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery. International Journal of Nanomedicine 6:1621–30. doi: 10.2147/ijn.S22411.
  • Thanou, M., J. C. Verhoef, and H. E. Junginger. 2001. Oral drug absorption enhancement by chitosan and its derivatives. Advanced Drug Delivery Reviews 52 (2):117–26. doi: 10.1016/S0169-409X(01)00231-9.
  • Toragall, V., N. Jayapala, and B. Vallikannan. 2020. Chitosan-oleic acid-sodium alginate a hybrid nanocarrier as an efficient delivery system for enhancement of lutein stability and bioavailability. International Journal of Biological Macromolecules 150:578–94. doi: 10.1016/j.ijbiomac.2020.02.104.
  • Urso, R., P. Blardi, and G. Giorgi. 2002. A short introduction to pharmacokinetics. European Review for Medical and Pharmacological Sciences 6 (2-3):33–44.
  • Vishwanathan, R., M. Kuchan, S. Sen, and E. Johnson. 2014. Lutein is the predominant carotenoid in infant brain: Preterm infants have decreased concentrations of brain carotenoids. Journal of Pediatric Gastroenterology and Nutrition 59:659–65. doi: 10.1097/MPG.0000000000000389.
  • Vishwanathan, R., T. Wilson, and R. Nicolosi. 2009. Bioavailability of a nanoemulsion of lutein is greater than a lutein supplement. Nano Biomedicine and Engineering 1 (1):38–49. doi: 10.5101/nbe.v1i1.p38-49.
  • Vroman, I., and L. Tighzert. 2009. Biodegradable polymers. Materials 2 (2):307–44. doi: 10.3390/ma2020307.
  • Wacker, M. G., A. Proykova, and G. M. L. Santos. 2016. Dealing with nanosafety around the globe-regulation vs. innovation. International Journal of Pharmaceutics 509 (1-2):95–106. doi: 10.1016/j.ijpharm.2016.05.015.
  • Watkins, R., L. Wu, C. Zhang, R. M. Davis, and B. Xu. 2015. Natural product-based nanomedicine: Recent advances and issues. International Journal of Nanomedicine 10:6055–74. doi: 10.2147/ijn.S92162.
  • Wu, M., Z. Feng, Y. Deng, C. Zhong, Y. Liu, J. Liu, X. Zhao, and Y. Fu. 2019. Liquid antisolvent precipitation: An effective method for ocular targeting of lutein esters. International Journal of Nanomedicine 14:2667–81. doi: 10.2147/IJN.S194068.
  • Xue, C., R. Rosen, A. Jordan, and D.-N. Hu. 2015. Management of ocular diseases using lutein and zeaxanthin: What have we learned from experimental animal studies? Journal of Ophthalmology 2015:523027. doi: 10.1155/2015/523027.
  • Zhang, L.-H., X.-D. Xu, B. Shao, Q. Shen, H. Zhou, Y.-M. Hong, and L.-M. Yu. 2015. Physicochemical properties and bioavailability of lutein microencapsulation (LM). Food Science and Technology Research 21 (4):503–7. doi: 10.3136/fstr.21.503.

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