Health promoting properties and sensory characteristics of phytochemicals in berries and leaves of sea buckthorn (Hippophaë rhamnoides)

References

• Aaby, K., B. K. Martinsen, G. I. Borge, and D. Røen. 2020. Bioactive compounds and color of sea buckthorn (Hippophae rhamnoides L.) purees as affected by heat treatment and high-pressure homogenization. International Journal of Food Properties 23 (1):651–64. doi: 10.1080/10942912.2020.1752715.
   Web of Science ®Google Scholar
• Aerts, R. J., T. N. Barry, and W. C. McNabb. 1999. Polyphenols and agriculture: Beneficial effects of proanthocyanidins in forages. Agriculture, Ecosystems & Environment 75 (1-2):1–12. doi: 10.1016/S0167-8809(99)00062-6.
   Web of Science ®Google Scholar
• Ahn, J., H. Lee, S. Kim, J. Park, and T. Ha. 2008. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochemical and Biophysical Research Communications 373 (4):545–9. doi: 10.1016/j.bbrc.2008.06.077.
   PubMed Web of Science ®Google Scholar
• Alexandrakis, Z., K. Kyriakopoulou, G. Katsaros, M. Krokida, and P. Taoukis. 2014. Selection of process conditions for high pressure pasteurization of sea buckthorn juice retaining high antioxidant activity. Food and Bioprocess Technology 7 (11):3226–34. doi: 10.1007/s11947-014-1299-5.
   Web of Science ®Google Scholar
• Amarowicz, R., R. Carle, G. Dongowski, A. Durazzo, R. Galensa, D. Kammerer, G. Maiani, and M. K. Piskula. 2009. Influence of postharvest processing and storage on the content of phenolic acids and flavonoids in foods. Molecular Nutrition & Food Research 53 (S2):S151–S183. doi: 10.1002/mnfr.200700486.
   PubMedGoogle Scholar
• Andersson, S. C., M. E. Olsson, E. Johansson, and K. Rumpunen. 2009. Carotenoids in sea buckthorn (Hippophae rhamnoides L.) berries during ripening and use of pheophytin a as a maturity marker. Journal of Agricultural and Food Chemistry 57 (1):250–8. doi: 10.1021/jf802599f.
   PubMed Web of Science ®Google Scholar
• Andreux, P. A., W. Blanco-Bose, D. Ryu, F. Burdet, M. Ibberson, P. Aebischer, J. Auwerx, A. Singh, and C. Rinsch. 2019. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism 1 (6):595–603. doi: 10.1038/s42255-019-0073-4.
   PubMedGoogle Scholar
• Apers, S., Y. Huang, S. V. Miert, R. Dommisse, D. V. Berghe, L. Pieters, and A. Vlietinck. 2002. Characterisation of new oligoglycosidic compounds in two Chinese medicinal herbs. Phytochemical Analysis 13 (4):202–6. doi: 10.1002/pca.642.
   PubMed Web of Science ®Google Scholar
• Arimboor, R., and C. Arumughan. 2011. Sea buckthorn (Hippophae rhamnoides) proanthocyanidins inhibit in vitro enzymatic hydrolysis of protein. Journal of Food Science 76 (6):T130–T137. doi: 10.1111/j.1750-3841.2011.02238.x.
   PubMed Web of Science ®Google Scholar
• Arimboor, R., K. S. Kumar, and C. Arumughan. 2008. Simultaneous estimation of phenolic acids in sea buckthorn (Hippophae rhamnoides) using RP-HPLC with DAD. Journal of Pharmaceutical and Biomedical Analysis 47 (1):31–8. doi: 10.1016/j.jpba.2007.11.045.
   PubMed Web of Science ®Google Scholar
• Aron, P. M., and J. A. Kennedy. 2008. Flavan‐3‐ols: Nature, occurrence and biological activity. Molecular Nutrition & Food Research 52 (1):79–104. doi: 10.1002/mnfr.200700137.
   PubMed Web of Science ®Google Scholar
• Arrigoni, O., and M. C. De Tullio. 2002. Ascorbic acid: Much more than just an antioxidant. Biochimica et Biophysica Acta (BBA) - General Subjects 1569 (1-3):1–9. doi: 10.1016/S0304-4165(01)00235-5.
   PubMed Web of Science ®Google Scholar
• Baba, S., N. Osakabe, M. Natsume, and J. Terao. 2002. Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. Free Radical Biology and Medicine 33 (1):142–8. doi: 10.1016/S0891-5849(02)00871-7.
   PubMed Web of Science ®Google Scholar
• Bajec, M. R., and G. J. Pickering. 2008. Astringency: Mechanisms and perception. Critical Reviews in Food Science and Nutrition 48 (9):858–75. doi: 10.1080/10408390701724223.
   PubMed Web of Science ®Google Scholar
• Bakkalbaşi, E., Ö. Menteş, and N. Artik. 2009. Food ellagitannins-occurrence, effects of processing and storage. Critical Reviews in Food Science and Nutrition 49 (3):283–98. doi: 10.1080/10408390802064404.
   PubMed Web of Science ®Google Scholar
• Bal, L. M., V. Meda, S. Naik, and S. Satya. 2011. Sea buckthorn berries: A potential source of valuable nutrients for nutraceuticals and cosmoceuticals. Food Research International 44 (7):1718–27. doi: 10.1016/j.foodres.2011.03.002.
   Web of Science ®Google Scholar
• Basu, M., R. Prasad, P. Jayamurthy, K. Pal, C. Arumughan, and R. Sawhney. 2007. Anti-atherogenic effects of seabuckthorn (Hippophaea rhamnoides) seed oil. Phytomedicine 14 (11):770–7. doi: 10.1016/j.phymed.2007.03.018.
   PubMed Web of Science ®Google Scholar
• Bekker, N., and A. Glushenkova. 2001. Components of certain species of the Elaeagnaceae family. Chemistry of Natural Compounds 37 (2):97–116. doi: 10.1023/A:1012395332284.
   Web of Science ®Google Scholar
• Belitz, H. D., W. Grosch, and P. Schieberle. 2004. Food chemistry. 3rd revised ed., 806–60. Berlin, Germany: Springer Science & Business Media.
   Google Scholar
• Beveridge, T., T. S. Li, B. D. Oomah, and A. Smith. 1999. Sea buckthorn products: Manufacture and composition. Journal of Agricultural and Food Chemistry 47 (9):3480–8. doi: 10.1021/jf981331m.
   PubMed Web of Science ®Google Scholar
• Bittová, M., E. Krejzová, V. Roblová, P. Kubáň, and V. Kubáň. 2014. Monitoring of HPLC profiles of selected polyphenolic compounds in sea buckthorn (Hippophaë rhamnoides L.) plant parts during annual growth cycle and estimation of their antioxidant potential. Central European Journal of Chemistry 12 (11):1152–61.
   Google Scholar
• Bufe, B., T. Hofmann, D. Krautwurst, J. Raguse, and W. Meyerhof. 2002. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nature Genetics 32 (3):397–401. doi: 10.1038/ng1014.
   PubMed Web of Science ®Google Scholar
• Cerdá, B., P. Periago, J. C. Espín, and F. A. Tomás-Barberán. 2005. Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. Journal of Agricultural and Food Chemistry 53 (14):5571–6. doi: 10.1021/jf050384i.
   PubMed Web of Science ®Google Scholar
• Challacombe, C. A., E. M. Abdel-Aal, K. Seetharaman, and L. M. Duizer. 2012. Influence of phenolic acid content on sensory perception of bread and crackers made from red or white wheat. Journal of Cereal Science 56 (2):181–8. doi: 10.1016/j.jcs.2012.03.006.
   Web of Science ®Google Scholar
• Chan, E. W. C., Y. Y. Lim, S. K. Wong, K. Lim, S. Tan, F. Lianto, and M. Yong. 2009. Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species. Food Chemistry 113 (1):166–72. doi: 10.1016/j.foodchem.2008.07.090.
   Web of Science ®Google Scholar
• Chen, C., H. Zhang, W. Xiao, Z.-P. Yong, and N. Bai. 2007. High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berries. Journal of Chromatography A 1154 (1-2):250–9. doi:10.1016/j.chroma.2007.03.097.
   PubMed Web of Science ®Google Scholar
• Chen, C., X. Xu, Y. Chen, M. Yu, F. Wen, and H. Zhang. 2013. Identification, quantification and antioxidant activity of acylated flavonol glycosides from sea buckthorn (Hippophae rhamnoides ssp. sinensis). Food Chemistry 141 (3):1573–9. doi: 10.1016/j.foodchem.2013.03.092.
   PubMed Web of Science ®Google Scholar
• Cheng, J., K. Kondo, Y. Suzuki, Y. Ikeda, X. Meng, and K. Umemura. 2003. Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sciences 72 (20):2263–71. doi: 10.1016/S0024-3205(03)00114-0.
   PubMed Web of Science ®Google Scholar
• Ciesarová, Z., M. Murkovic, K. Cejpek, F. Kreps, B. Tobolková, R. Koplík, E. Belajová, K. Kukurová, Ľ. Daško, Z. Panovská, et al. 2020. Why is sea buckthorn (Hippophae rhamnoides L.) So exceptional? A review. Food Research International 133:109170. doi: 10.1016/j.foodres.2020.109170.
   PubMed Web of Science ®Google Scholar
• Clair, E., B. Yang, T. Raija, K. Heikki, H. R. Gerald, and M. A. Minihane. 2002. Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans. The Journal of Nutritional Biochemistry 13 (6):346–54. doi: 10.1016/S0955-2863(02)00179-1.
   PubMed Web of Science ®Google Scholar
• Delcour, J. A., M. M. Vandenberghe, P. F. Corten, and P. Dondeyne. 1984. Flavor thresholds of polyphenolics in water. American Journal of Enology and Viticulture 35 (3):134–6.
   Web of Science ®Google Scholar
• Deng, G., X. Xu, Y. Zhang, D. Li, R. Gan, and H. Li. 2013. Phenolic compounds and bioactivities of pigmented rice. Critical Reviews in Food Science and Nutrition 53 (3):296–306. doi: 10.1080/10408398.2010.529624.
   PubMed Web of Science ®Google Scholar
• Donovan, J. L., A. Lee, C. Manach, L. Rios, C. Morand, A. Scalbert, and C. Rémésy. 2002. Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3. British Journal of Nutrition 87 (4):299–306. doi: 10.1079/BJN2001517.
   PubMed Web of Science ®Google Scholar
• Du, L., M. Zhao, J. Xu, D. Qian, S. Jiang, E. Shang, J. Guo, and J. Duan. 2014. Analysis of the metabolites of isorhamnetin 3-O-glucoside produced by human intestinal flora in vitro by applying ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of Agricultural and Food Chemistry 62 (12):2489–95. doi: 10.1021/jf405261a.
   PubMed Web of Science ®Google Scholar
• Fan, J., X. Ding, and W. Gu. 2007. Radical-scavenging proanthocyanidins from sea buckthorn seed. Food Chemistry 102 (1):168–77. doi: 10.1016/j.foodchem.2006.05.049.
   Web of Science ®Google Scholar
• Ferreira, D., and D. Slade. 2002. Oligomeric proanthocyanidins: Naturally occurring O-heterocycles. Natural Product Reports 19 (5):517–41. doi: 10.1039/b008741f.
   PubMed Web of Science ®Google Scholar
• Fonteles, M., M. Almeida, and J. Larner. 2000. Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with manganese in streptozotocin diabetic rats. Hormone and Metabolic Research 32 (04):129–32. doi: 10.1055/s-2007-978606.
   PubMedGoogle Scholar
• Frank, O., G. Zehentbauer, and T. Hofmann. 2006. Bioresponse-guided decomposition of roast coffee beverage and identification of key bitter taste compounds. European Food Research and Technology 222 (5-6):492–508. doi: 10.1007/s00217-005-0143-6.
   Web of Science ®Google Scholar
• Ganju, L., Y. Padwad, R. Singh, D. Karan, S. Chanda, M. K. Chopra, P. Bhatnagar, R. Kashyap, and R. C. Sawhney. 2005. Anti-inflammatory activity of Sea buckthorn (Hippophae rhamnoides) leaves. International Immunopharmacology 5 (12):1675–84. doi: 10.1016/j.intimp.2005.03.017.
   PubMed Web of Science ®Google Scholar
• Gao, X., M. Ohlander, N. Jeppsson, L. Björk, and V. Trajkovski. 2000. Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea buckthorn (Hippophae rhamnoides L.) during maturation. Journal of Agricultural and Food Chemistry 48 (5):1485–90. doi: 10.1021/jf991072g.
   PubMed Web of Science ®Google Scholar
• Geertsen, J., B. H. Allesen-Holm, D. V. Byrne, and D. Giacalone. 2016. Consumer-led development of novel sea buckthorn-based beverages. Journal of Sensory Studies 31 (3):245–55. doi: 10.1111/joss.12207.
   Web of Science ®Google Scholar
• Geetha, S., V. Singh, M. S. Ram, G. Ilavazhagan, P. Banerjee, and R. Sawhney. 2005. Immunomodulatory effects of sea buckthorn (Hippophae rhamnoides L.) against chromium (VI) induced immunosuppression. Molecular and Cellular Biochemistry 278 (1-2):101–9. doi: 10.1007/s11010-005-7095-9.
   PubMed Web of Science ®Google Scholar
• Geetha, S., P. Jayamurthy, K. Pal, S. Pandey, R. Kumar, and R. Sawhney. 2008. Hepatoprotective effects of sea buckthorn (Hippophae rhamnoides L.) against carbon tetrachloride induced liver injury in rats. Journal of the Science of Food and Agriculture 88 (9):1592–7. doi: 10.1002/jsfa.3255.
   Web of Science ®Google Scholar
• Glabasnia, A., and T. Hofmann. 2006. Sensory-directed identification of taste-active ellagitannins in American (Quercus alba L.) and European oak wood (Quercus robur L.) and quantitative analysis in bourbon whiskey and oak-matured red wines. Journal of Agricultural and Food Chemistry 54 (9):3380–90. doi: 10.1021/jf052617b.
   PubMed Web of Science ®Google Scholar
• Glabasnia, A., and T. Hofmann. 2007. Identification and sensory evaluation of dehydro- and deoxy-ellagitannins formed upon toasting of oak wood (Quercus alba L.). Journal of Agricultural and Food Chemistry 55 (10):4109–18. doi: 10.1021/jf070151m.
   PubMed Web of Science ®Google Scholar
• Gonthier, M., J. L. Donovan, O. Texier, C. Felgines, C. Remesy, and A. Scalbert. 2003. Metabolism of dietary procyanidins in rats. Free Radical Biology & Medicine 35 (8):837–44. doi: 10.1016/S0891-5849(03)00394-0.
   PubMed Web of Science ®Google Scholar
• Graefe, E. U., J. Wittig, S. Mueller, A. Riethling, B. Uehleke, B. Drewelow, H. Pforte, G. Jacobasch, H. Derendorf, and M. Veit. 2001. Pharmacokinetics and bioavailability of quercetin glycosides in humans. Journal of Clinical Pharmacology 41 (5):492–9. doi: 10.1177/00912700122010366.
   PubMed Web of Science ®Google Scholar
• Grey, C., C. Widén, P. Adlercreutz, K. Rumpunen, and R. Duan. 2010. Antiproliferative effects of sea buckthorn (Hippophae rhamnoides L.) extracts on human colon and liver cancer cell lines. Food Chemistry 120 (4):1004–10. doi: 10.1016/j.foodchem.2009.11.039.
   Web of Science ®Google Scholar
• Guan, T. T., S. Cenkowski, and A. Hydamaka. 2006. Effect of drying on the nutraceutical quality of sea buckthorn (Hippophae rhamnoides L. ssp. sinensis) leaves. Journal of Food Science 70 (9):E514–E518. doi: 10.1111/j.1365-2621.2005.tb08312.x.
   Web of Science ®Google Scholar
• Guliyev, V. B., M. Gul, and A. Yildirim. 2004. Hippophae rhamnoides L.: Chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 812 (1-2):291–307. doi: 10.1016/S1570-0232(04)00720-2.
   PubMed Web of Science ®Google Scholar
• Guo, R., X. Guo, T. Li, X. Fu, and R. H. Liu. 2017. Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries. Food Chemistry 221:997–1003. doi: 10.1016/j.foodchem.2016.11.063.
   PubMed Web of Science ®Google Scholar
• Gupta, A., R. Kumar, K. Pal, V. Singh, P. K. Banerjee, and R. C. Sawhney. 2006. Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats. Molecular and Cellular Biochemistry 290 (1-2):193–8. doi: 10.1007/s11010-006-9187-6.
   PubMed Web of Science ®Google Scholar
• Gutzeit, D., G. Baleanu, P. Winterhalter, and G. Jerz. 2008. Vitamin C content in sea buckthorn berries (Hippophae rhamnoides L. ssp. rhamnoides) and related products: A kinetic study on storage stability and the determination of processing effects. Journal of Food Science 73 (9):C615–20. doi: 10.1111/j.1750-3841.2008.00957.x.
   PubMed Web of Science ®Google Scholar
• Heinonen, M. 2007. Antioxidant activity and antimicrobial effect of berry phenolics—A Finnish perspective. Molecular Nutrition & Food Research 51 (6):684–91. doi: 10.1002/mnfr.200700006.
   PubMed Web of Science ®Google Scholar
• Higgins, J. A., J. C. B. Miller, and G. S. Denyer. 1996. Development of insulin resistance in the rat is dependent on the rate of glucose absorption from the diet. The Journal of Nutrition 126 (3):596–602. doi: 10.1093/jn/126.3.596.
   PubMed Web of Science ®Google Scholar
• Hofmann, T., A. Glabasnia, B. Schwarz, K. N. Wisman, K. A. Gangwer, and A. E. Hagerman. 2006. Protein binding and astringent taste of a polymeric procyanidin, 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose, castalagin, and grandinin. Journal of Agricultural and Food Chemistry 54 (25):9503–9. doi: 10.1021/jf062272c.
   PubMed Web of Science ®Google Scholar
• Hollman, P., and M. Katan. 1997. Absorption, metabolism and health effects of dietary flavonoids in man. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 51 (8):305–10. doi: 10.1016/S0753-3322(97)88045-6.
   PubMed Web of Science ®Google Scholar
• Hraš, A. R., M. Hadolin, Ž. Knez, and D. Bauman. 2000. Comparison of antioxidative and synergistic effects of rosemary extract with α-tocopherol, ascorbyl palmitate and citric acid in sunflower oil. Food Chemistry 71 (2):229–33. doi: 10.1016/S0308-8146(00)00161-8.
   Web of Science ®Google Scholar
• Hufnagel, J. C., and T. Hofmann. 2008. Orosensory-directed identification of astringent mouthfeel and bitter-tasting compounds in red wine. Journal of Agricultural and Food Chemistry 56 (4):1376–86. doi: 10.1021/jf073031n.
   PubMed Web of Science ®Google Scholar
• Jacques, P. F., A. Cassidy, G. Rogers, J. J. Peterson, J. B. Meigs, and J. T. Dwyer. 2013. Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes. The Journal of Nutrition 143 (9):1474–80. doi: 10.3945/jn.113.177212.
   PubMed Web of Science ®Google Scholar
• Jaroszewska, A., and W. Biel. 2017. Chemical composition and antioxidant activity of leaves of mycorrhized sea-buckthorn (Hippophae rhamnoides L.). Chilean Journal of Agricultural Research 77 (2):155–62. doi: 10.4067/S0718-58392017000200155.
   Web of Science ®Google Scholar
• Jiménez-Aspee, F., C. Quispe, M. d Pilar, C. Soriano, J. F. Gonzalez, E. Hüneke, C. Theoduloz, and G. Schmeda-Hirschmann. 2014. Antioxidant activity and characterization of constituents in copao fruits (Eulychnia acida Phil., Cactaceae) by HPLC–DAD–MS/MSn. Food Research International 62:286–98. doi: 10.1016/j.foodres.2014.03.013.
   Web of Science ®Google Scholar
• Johansson, A. K., H. Korte, B. Yang, J. C. Stanley, and H. P. Kallio. 2000. Sea buckthorn berry oil inhibits platelet aggregation. The Journal of Nutritional Biochemistry 11 (10):491–5. doi: 10.1016/S0955-2863(00)00105-4.
   PubMed Web of Science ®Google Scholar
• Kahle, K., M. Kraus, W. Scheppach, M. Ackermann, F. Ridder, and E. Richling. 2006. Studies on apple and blueberry fruit constituents: Do the polyphenols reach the colon after ingestion? Molecular Nutrition & Food Research 50 (4-5):418–23. doi: 10.1002/mnfr.200500211.
   PubMed Web of Science ®Google Scholar
• Kallio, H., B. Yang, and P. Peippo. 2002. Effects of different origins and harvesting time on vitamin C, tocopherols, and tocotrienols in sea buckthorn (Hippophaë rhamnoides) berries. Journal of Agricultural and Food Chemistry 50 (21):6136–42. doi: 10.1021/jf020421v.
   PubMed Web of Science ®Google Scholar
• Kallio, H., B. Yang, P. Peippo, R. Tahvonen, and R. Pan. 2002. Triacylglycerols, glycerophospholipids, tocopherols, and tocotrienols in berries and seeds of two subspecies (ssp. sinensis and mongolica) of sea buckthorn (Hippophaë rhamnoides). Journal of Agricultural and Food Chemistry 50 (10):3004–9. doi: 10.1021/jf011556o.
   PubMed Web of Science ®Google Scholar
• Kallio, H., M. Lassila, E. Järvenpää, G. G. Haraldsson, S. Jonsdottir, and B. Yang. 2009. Inositols and methylinositols in sea buckthorn (Hippophaë rhamnoides) berries. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 877 (14-15):1426–32. doi: 10.1016/j.jchromb.2009.03.027.
   PubMed Web of Science ®Google Scholar
• Kallio, H., W. Yang, P. Liu, and B. Yang. 2014. Proanthocyanidins in wild sea buckthorn (Hippophaë rhamnoides) berries analyzed by reversed-phase, normal-phase, and hydrophilic interaction liquid chromatography with UV and MS detection. Journal of Agricultural and Food Chemistry 62 (31):7721–9. doi: 10.1021/jf502056f.
   PubMed Web of Science ®Google Scholar
• Kampa, M., V.-I. Alexaki, G. Notas, A.-P. Nifli, A. Nistikaki, A. Hatzoglou, E. Bakogeorgou, E. Kouimtzoglou, G. Blekas, D. Boskou, et al. 2004. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: Potential mechanisms of action. Breast Cancer Research 6 (2):R63–R74. doi: 10.1186/bcr752.
   PubMed Web of Science ®Google Scholar
• Kim, J., Y. Kwon, Y. Sa, and M. Kim. 2011. Isolation and identification of sea buckthorn (Hippophae rhamnoides) phenolics with antioxidant activity and α-glucosidase inhibitory effect. Journal of Agricultural and Food Chemistry 59 (1):138–44. doi: 10.1021/jf103130a.
   PubMed Web of Science ®Google Scholar
• Korekar, G., P. Dolkar, H. Singh, R. B. Srivastava, and T. Stobdan. 2014. Variability and the genotypic effect on antioxidant activity, total phenolics, carotenoids and ascorbic acid content in seventeen natural population of Seabuckthorn (Hippophae rhamnoides L.) from trans-Himalaya. Lwt - Food Science and Technology 55 (1):157–62. doi: 10.1016/j.lwt.2013.09.006.
   Web of Science ®Google Scholar
• Korekar, G., T. Stobdan, H. Singh, O. Chaurasia, and S. Singh. 2011. Phenolic content and antioxidant capacity of various solvent extracts from sea buckthorn (Hippophae rhamnoides L.) fruit pulp, seeds, leaves and stem bark. Acta Alimentaria 40 (4):449–58. doi: 10.1556/AAlim.40.2011.4.4.
   Web of Science ®Google Scholar
• Kortesniemi, M., J. Sinkkonen, B. Yang, and H. Kallio. 2014. H-1 NMR spectroscopy reveals the effect of genotype and growth conditions on composition of sea buckthorn (Hippophae rhamnoides L.) berries. Food Chemistry 147:138–46. doi: 10.1016/j.foodchem.2013.09.133.
   PubMed Web of Science ®Google Scholar
• Kortesniemi, M., J. Sinkkonen, B. Yang, and H. Kallio. 2017. NMR metabolomics demonstrates phenotypic plasticity of sea buckthorn (Hippophaë rhamnoides) berries with respect to growth conditions in Finland and Canada. Food Chemistry 219:139–47. doi: 10.1016/j.foodchem.2016.09.125.
   PubMed Web of Science ®Google Scholar
• Kyriakopoulou, K., A. Pappa, M. Krokida, A. Detsi, and P. Kefalas. 2013. Effects of drying and extraction methods on the quality and antioxidant activity of sea buckthorn (Hippophae rhamnoides) berries and leaves. Drying Technology 31 (9):1063–76. doi: 10.1080/07373937.2013.773907.
   Web of Science ®Google Scholar
• Laaksonen, O., A. Knaapila, T. Niva, K. C. Deegan, and M. Sandell. 2016. Sensory properties and consumer characteristics contributing to liking of berries. Food Quality and Preference 53:117–26. doi: 10.1016/j.foodqual.2016.06.004.
   Web of Science ®Google Scholar
• Laaksonen, O., J. Ahola, and M. Sandell. 2013. Explaining and predicting individually experienced liking of berry fractions by the hTAS2R38 taste receptor genotype. Appetite 61 (1):85–96. doi: 10.1016/j.appet.2012.10.023.
   PubMedGoogle Scholar
• Laaksonen, O. A., J.-P. Salminen, L. Mäkilä, H. P. Kallio, and B. Yang. 2015. Proanthocyanidins and their contribution to sensory attributes of black currant juices. Journal of Agricultural and Food Chemistry 63 (22):5373–80. doi: 10.1021/acs.jafc.5b01287.
   PubMed Web of Science ®Google Scholar
• Lafay, S., and A. Gil-Izquierdo. 2008. Bioavailability of phenolic acids. Phytochemistry Reviews 7 (2):301–11. doi: 10.1007/s11101-007-9077-x.
   Google Scholar
• Landete, J. 2011. Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health. Food Research International 44 (5):1150–60. doi: 10.1016/j.foodres.2011.04.027.
   Web of Science ®Google Scholar
• Langhans, W. 2018. Food components in health promotion and disease prevention. Journal of Agricultural and Food Chemistry 66 (10):2287–94. doi: 10.1021/acs.jafc.7b02121.
   PubMed Web of Science ®Google Scholar
• Larmo, P. S., B. Yang, J. Hyssälä, H. P. Kallio, and R. Erkkola. 2014. Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study. Maturitas 79 (3):316–21. doi: 10.1016/j.maturitas.2014.07.010.
   PubMed Web of Science ®Google Scholar
• Larmo, P., R. Järvinen, J. Laihia, E. Löyttyniemi, L. Maavirta, B. Yang, H. Kallio, and M. Sandberg-Lall. 2019. Effects of a sea buckthorn oil spray emulsion on dry eye. Contact Lens & Anterior Eye : The Journal of the British Contact Lens Association 42 (4):428–33. doi: 10.1016/j.clae.2018.11.011.
   PubMed Web of Science ®Google Scholar
• Lawless, H. T., J. Horne, and P. Giasi. 1996. Astringency of organic acids is related to pH. Chemical Senses 21 (4):397–403. doi: 10.1093/chemse/21.4.397.
   PubMed Web of Science ®Google Scholar
• Lee, S. K., and A. A. Kader. 2000. Preharvest and postharvest factors influencing vitamin C content of horticultural crops. Postharvest Biology and Technology 20 (3):207–20. doi: 10.1016/S0925-5214(00)00133-2.
   Web of Science ®Google Scholar
• Lesjak, M., I. Beara, N. Simin, D. Pintać, T. Majkić, K. Bekvalac, D. Orčić, and N. Mimica-Dukić. 2018. Antioxidant and anti-inflammatory activities of quercetin and its derivatives. Journal of Functional Foods 40:68–75. doi: 10.1016/j.jff.2017.10.047.
   Web of Science ®Google Scholar
• Lesschaeve, I., and A. C. Noble. 2005. Polyphenols: Factors influencing their sensory properties and their effects on food and beverage preferences. The American Journal of Clinical Nutrition 81 (1 Suppl):330S–5S. doi: 10.1093/ajcn/81.1.330S.
   PubMed Web of Science ®Google Scholar
• Levavasseur, M., C. Becquart, E. Pape, M. Pigeyre, J. Rousseaux, D. Staumont-Sallé, and E. Delaporte. 2015. Severe scurvy: An underestimated disease. European Journal of Clinical Nutrition 69 (9):1076–7. doi: 10.1038/ejcn.2015.99.
   PubMed Web of Science ®Google Scholar
• Li, C., X. Yang, C. Chen, S. Cai, and J. Hu. 2014. Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway . Molecular Medicine Reports 9 (3):935–40. doi: 10.3892/mmr.2014.1886.
   PubMed Web of Science ®Google Scholar
• Li, T. S., T. H. Beveridge, and J. C. Drover. 2007. Phytosterol content of sea buckthorn (Hippophae rhamnoides L.) seed oil: Extraction and identification. Food Chemistry 101 (4):1633–9. doi: 10.1016/j.foodchem.2006.04.033.
   Web of Science ®Google Scholar
• Lindstedt, A., R. Järvinen, J. Sinkkonen, H. Lehtonen, G. Graça, M. Viitanen, A. M. Gil, and H. Kallio. 2014. Postprandial response on fatty meal is affected by sea buckthorn (Hippophaë rhamnoides) supplementation: NMR metabolomics study. Food Research International 58:23–34. doi: 10.1016/j.foodres.2013.12.010.
   Web of Science ®Google Scholar
• Ludwig, I. A., P. Mena, L. Calani, G. Borges, G. Pereira-Caro, L. Bresciani, D. Del Rio, M. E. Lean, and A. Crozier. 2015. New insights into the bioavailability of red raspberry anthocyanins and ellagitannins. Free Radical Biology & Medicine 89:758–69. doi: 10.1016/j.freeradbiomed.2015.10.400.
   PubMed Web of Science ®Google Scholar
• Luo, Y., G. Sun, X. Dong, M. Wang, M. Qin, Y. Yu, and X. Sun. 2015. Isorhamnetin attenuates atherosclerosis by inhibiting macrophage apoptosis via PI3K/AKT activation and HO-1 induction. PLoS One 10 (3):e0120259. doi: 10.1371/journal.pone.0120259.
   PubMed Web of Science ®Google Scholar
• Ma, W., A. Guo, Y. Zhang, H. Wang, Y. Liu, and H. Li. 2014. A review on astringency and bitterness perception of tannins in wine. Trends in Food Science & Technology 40 (1):6–19. doi: 10.1016/j.tifs.2014.08.001.
   Web of Science ®Google Scholar
• Ma, X., J. Moilanen, O. Laaksonen, W. Yang, E. Tenhu, and B. Yang. 2019. Phenolic compounds and antioxidant activities of tea-type infusions processed from sea buckthorn (Hippophaë rhamnoides) leaves. Food Chemistry 272:1–11. doi: 10.1016/j.foodchem.2018.08.006.
   PubMed Web of Science ®Google Scholar
• Ma, X., O. Laaksonen, J. Heinonen, T. Sainio, H. Kallio, and B. Yang. 2017. Sensory profile of ethyl β-D-glucopyranoside and its contribution to quality of sea buckthorn (Hippophaë rhamnoides L.). Food Chem 233:263–72. doi: 10.1016/j.foodchem.2017.04.073.
   PubMed Web of Science ®Google Scholar
• Ma, X., O. Laaksonen, J. Zheng, W. Yang, M. Trépanier, H. Kallio, and B. Yang. 2016. Flavonol glycosides in berries of two major subspecies of sea buckthorn (Hippophaë rhamnoides L.) and influence of growth sites. Food Chemistry 200:189–98. doi: 10.1016/j.foodchem.2016.01.036.
   PubMed Web of Science ®Google Scholar
• Ma, X., W. Yang, O. A. Laaksonen, M. Nylander, H. Kallio, and B. Yang. 2017. Role of flavonols and proanthocyanidins in the sensory quality of sea buckthorn (Hippophaë rhamnoides L.) berries. Journal of Agricultural and Food Chemistry 65 (45):9871–9. doi: 10.1021/acs.jafc.7b04156.
   PubMed Web of Science ®Google Scholar
• Ma, X., W. Yang, A. Marsol-Vall, O. Laaksonen, and B. Yang. 2020. Analysis of flavour compounds and prediction of sensory properties in sea buckthorn (Hippophaë rhamnoides L.) berries. International Journal of Food Science & Technology 55 (4):1705–15. doi: 10.1111/ijfs.14442.
   Web of Science ®Google Scholar
• Maga, J., and K. Lorenz. 1973. Taste threshold values for phenolic acids which can influence flavor properties of certain flours, grains and oilseeds. Cereal Science Today 18:326–8.
   Google Scholar
• Malinowska, P., and B. Olas. 2016. Sea buckthorn–valuable plant for health. Kosmos 2:285–92.
   Google Scholar
• Manach, C., G. Williamson, C. Morand, A. Scalbert, and C. Remesy. 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. The American Journal of Clinical Nutrition 81 (1 Suppl):230S–42S. doi: 10.1093/ajcn/81.1.230S.
   PubMed Web of Science ®Google Scholar
• Markkinen, N., O. Laaksonen, R. Nahku, R. Kuldjärv, and B. Yang. 2019. Impact of lactic acid fermentation on acids, sugars, and phenolic compounds in black chokeberry and sea buckthorn juices. Food Chemistry 286:204–15. doi: 10.1016/j.foodchem.2019.01.189.
   PubMed Web of Science ®Google Scholar
• Marles, M. S., H. Ray, and M. Y. Gruber. 2003. New perspectives on proanthocyanidin biochemistry and molecular regulation. Phytochemistry 64 (2):367–83. doi: 10.1016/S0031-9422(03)00377-7.
   PubMed Web of Science ®Google Scholar
• Marnila, P., J. Hellström, J. Pihlava, S. Örling, P. Mattila, and S. Kauppinen. 2013. Sea buckthorn leaves–processing waste with anti-inflammatory properties. Proceedings of the 6th Conference of the International Seabuckthorn Association, SBT-a Fresh Look at Technology, Health and Environment, 96–100.
   Google Scholar
• Martin, C., Y. Zhang, C. Tonelli, and K. Petroni. 2013. Plants, diet, and health. Annual Review of Plant Biology 64 (1):19–46. doi: 10.1146/annurev-arplant-050312-120142.
   PubMedGoogle Scholar
• Matsubara, Y., T. Mizuno, A. Sawabe, Y. Iizuka, and K. Okamoto. 1989. Structure and physiological activity of nitrogenous compounds and alkyl glycosides in lemon (Citrus limon Burm. f.), unshiu (Citrus unshiu MARCOV.), Hassaku (Citrus hassaku HORT.), yuzu (Citrus junos SIEB.) and iyokan (Citrus iyo) peelings. Journal of the Agricultural Chemical Society of Japan 63 (8):1373–7. doi: 10.1271/nogeikagaku1924.63.1373.
   Google Scholar
• Mcdougall, G. J., and D. Stewart. 2005. The inhibitory effects of berry polyphenols on digestive enzymes. BioFactors 23 (4):189–95. doi: 10.1002/biof.5520230403.
   PubMed Web of Science ®Google Scholar
• McKay, D. L., C. O. Chen, C. A. Zampariello, and J. B. Blumberg. 2015. Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults. Food Chemistry 168:233–40. doi: 10.1016/j.foodchem.2014.07.062.
   PubMed Web of Science ®Google Scholar
• Mertens-Talcott, S. U., P. Jilma-Stohlawetz, J. Rios, L. Hingorani, and H. Derendorf. 2006. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers. Journal of Agricultural and Food Chemistry 54 (23):8956–61. doi: 10.1021/jf061674h.
   PubMed Web of Science ®Google Scholar
• Meyerhof, W., C. Batram, C. Kuhn, A. Brockhoff, E. Chudoba, B. Bufe, G. Appendino, and M. Behrens. 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chemical Senses 35 (2):157–70. doi: 10.1093/chemse/bjp092.
   PubMed Web of Science ®Google Scholar
• Mikulic-Petkovsek, M., A. Slatnar, F. Stampar, and R. Veberic. 2012. HPLC-MSn identification and quantification of flavonol glycosides in 28 wild and cultivated berry species. Food Chemistry 135 (4):2138–46. doi: 10.1016/j.foodchem.2012.06.115.
   PubMed Web of Science ®Google Scholar
• Mishima, T., S. Harino, J. Sugita, M. Nakahara, T. Suzuki, and T. Hayakawa. 2008. Plasma kinetics and urine profile of ethyl glucosides after oral administration in the rat. Bioscience, Biotechnology, and Biochemistry 72 (2):393–7. doi: 10.1271/bbb.70485.
   PubMed Web of Science ®Google Scholar
• Moilanen, J., M. Karonen, P. Tähtinen, R. Jacquet, S. Quideau, and J. Salminen. 2016. Biological activity of ellagitannins: Effects as anti-oxidants, pro-oxidants and metal chelators. Phytochemistry 125:65–72. doi: 10.1016/j.phytochem.2016.02.008.
   PubMed Web of Science ®Google Scholar
• Moilanen, J., P. Koskinen, and J. Salminen. 2015. Distribution and content of ellagitannins in Finnish plant species. Phytochemistry 116:188–97. doi: 10.1016/j.phytochem.2015.03.002.
   PubMed Web of Science ®Google Scholar
• Muscogiuri, G., S. Palomba, A. S. Laganà, and F. Orio. 2016. Inositols in the treatment of insulin-mediated diseases. International Journal of Endocrinology 2016:6189820. doi: 10.1155/2016/6189820.
   PubMed Web of Science ®Google Scholar
• Nabavi, S. M., S. F. Nabavi, S. Eslami, and A. H. Moghaddam. 2012. In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue. Food Chemistry 132 (2):931–5. doi: 10.1016/j.foodchem.2011.11.070.
   Web of Science ®Google Scholar
• Nardini, M., M. Forte, U. Vrhovsek, F. Mattivi, R. Viola, and C. Scaccini. 2009. White wine phenolics are absorbed and extensively metabolized in humans. Journal of Agricultural and Food Chemistry 57 (7):2711–8. doi: 10.1021/jf8034463.
   PubMed Web of Science ®Google Scholar
• Nascimento, N. R., L. M. Lessa, M. R. Kerntopf, C. M. Sousa, R. S. Alves, M. G. Queiroz, J. Price, D. B. Heimark, J. Larner, X. Du, et al. 2006. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide. Proceedings of the National Academy of Sciences of the United States of America 103 (1):218–23. doi: 10.1073/pnas.0509779103.
   PubMed Web of Science ®Google Scholar
• Olas, B. 2018. The beneficial health aspects of sea buckthorn (Elaeagnus rhamnoides (L.) A.Nelson) oil. Journal of Ethnopharmacology 213:183–90. doi: 10.1016/j.jep.2017.11.022.
   PubMed Web of Science ®Google Scholar
• Olas, B. 2016. Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases. Food and Chemical Toxicology 97:199–204. doi: 10.1016/j.fct.2016.09.008.
   PubMed Web of Science ®Google Scholar
• Ou, K., and L. Gu. 2014. Absorption and metabolism of proanthocyanidins. Journal of Functional Foods 7:43–53. doi: 10.1016/j.jff.2013.08.004.
   Web of Science ®Google Scholar
• Paterson, J., and J. Lawrence. 2001. Salicylic acid: A link between aspirin, diet and the prevention of colorectal cancer. QJM: An International Journal of Medicine 94 (8):445–8. doi: 10.1093/qjmed/94.8.445.
   PubMedGoogle Scholar
• Peleg, H., K. Gacon, P. Schlich, and A. C. Noble. 1999. Bitterness and astringency of flavan‐3‐ol monomers, dimers and trimers. Journal of the Science of Food and Agriculture 79 (8):1123–8. doi: 10.1002/(SICI)1097-0010(199906)79:8<1123::AID-JSFA336>3.0.CO;2-D.
   Web of Science ®Google Scholar
• Peleg, H., and A. Noble. 1999. Effect of viscosity, temperature and pH on astringency in cranberry juice. Food Quality and Preference 10 (4-5):343–7. doi: 10.1016/S0950-3293(99)00009-9.
   Web of Science ®Google Scholar
• Petersen, B., S. Egert, A. Bosy-Westphal, M. J. Müller, S. Wolffram, E. M. Hubbermann, G. Rimbach, and K. Schwarz. 2016. Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources. Food Research International 88 (Pt A):159–65. doi: 10.1016/j.foodres.2016.02.013.
   PubMedGoogle Scholar
• Pop, R. M., C. Socaciu, A. Pintea, A. D. Buzoianu, M. G. Sanders, H. Gruppen, and J. Vincken. 2013. UHPLC/PDA-ESI/MS analysis of the main berry and leaf flavonol glycosides from different Carpathian Hippophaë rhamnoides L. varieties . Phytochemical Analysis 24 (5):484–92. doi: 10.1002/pca.2460.
   PubMed Web of Science ®Google Scholar
• Pop, R. M., Y. Weesepoel, C. Socaciu, A. Pintea, J. Vincken, and H. Gruppen. 2014. Carotenoid composition of berries and leaves from six Romanian sea buckthorn (Hippophae rhamnoides L.) varieties. Food Chemistry 147:1–9. doi: 10.1016/j.foodchem.2013.09.083.
   PubMed Web of Science ®Google Scholar
• Puganen, A., H. Kallio, K. M. Schaich, J. Suomela, and B. Yang. 2018. Red/green currant and sea buckthorn berry press residues as potential sources of antioxidants for food use. Journal of Agricultural and Food Chemistry 66 (13):3426–34. doi: 10.1021/acs.jafc.8b00177.
   PubMed Web of Science ®Google Scholar
• Püssa, T., D. Anton, and P. Raudsepp. 2015. Stability of sea buckthorn berry polyphenols during cooking of enriched sausages. 61st International Congress of Meat Science and Technology. Clermont-Ferrand, France.
   Google Scholar
• Puupponen-Pimiä, R., T. Seppänen-Laakso, M. Kankainen, J. Maukonen, R. Törrönen, M. Kolehmainen, T. Leppänen, E. Moilanen, L. Nohynek, A.-M. Aura, et al. 2013. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Molecular Nutrition & Food Research 57 (12):2258–63. doi: 10.1002/mnfr.201300280.
   PubMed Web of Science ®Google Scholar
• Quijada-Morín, N., J. Regueiro, J. Simal-Gándara, E. Tomás, J. C. Rivas-Gonzalo, and M. T. Escribano-Bailón. 2012. Relationship between the sensory-determined astringency and the flavanolic composition of red wines. Journal of Agricultural and Food Chemistry 60 (50):12355–61. doi: 10.1021/jf3044346.
   PubMed Web of Science ®Google Scholar
• Radenkovs, V., T. Püssa, K. Juhnevica-Radenkova, D. Anton, and D. Seglina. 2018. Phytochemical characterization and antimicrobial evaluation of young leaf/shoot and press cake extracts from Hippophae rhamnoides L. Food Bioscience 24:56–66. doi: 10.1016/j.fbio.2018.05.010.
   Web of Science ®Google Scholar
• Ranard, K. M., M. J. Kuchan, and J. W. Erdman, Jr. 2019. α‐tocopherol, but not γ-tocopherol, attenuates the expression of selective tumor necrosis factor-alpha-induced genes in primary human aortic cell lines. Lipids 54 (5):289–99. doi: 10.1002/lipd.12149.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Roque, M. J., B. de Ancos, C. Sánchez-Moreno, M. P. Cano, P. Elez-Martínez, and O. Martín-Belloso. 2015. Impact of food matrix and processing on the in vitro bioaccessibility of vitamin C, phenolic compounds, and hydrophilic antioxidant activity from fruit juice-based beverages. Journal of Functional Foods 14:33–43. doi: 10.1016/j.jff.2015.01.020.
   Web of Science ®Google Scholar
• Roland, W. S., R. J. Gouka, H. Gruppen, M. Driesse, L. van Buren, G. Smit, and J. Vincken. 2014. 6-Methoxyflavanones as bitter taste receptor blockers for hTAS2R39. PLoS One 9 (4):e94451. doi: 10.1371/journal.pone.0094451.
   PubMed Web of Science ®Google Scholar
• Roland, W. S., L. van Buren, H. Gruppen, M. Driesse, R. J. Gouka, G. Smit, and J. Vincken. 2013. Bitter taste receptor activation by flavonoids and isoflavonoids: Modeled structural requirements for activation of hTAS2R14 and hTAS2R39. Journal of Agricultural and Food Chemistry 61 (44):10454–66. doi: 10.1021/jf403387p.
   PubMed Web of Science ®Google Scholar
• Rønning, S. B., V. Voldvik, S. K. Bergum, K. Aaby, and G. I. A. Borge. 2020. Ellagic acid and urolithin A modulate the immune response in LPS-stimulated U937 monocytic cells and THP-1 differentiated macrophages. Food & Function 11 (9):7946–59. doi: 10.1039/c9fo03008e.
   PubMed Web of Science ®Google Scholar
• Rösch, D., A. Krumbein, and L. W. Kroh. 2004. Antioxidant gallocatechins, dimeric and trimeric proanthocyanidins from sea buckthorn (Hippophae rhamnoides) pomace. European Food Research and Technology 219 (6):605–13. doi: 10.1007/s00217-004-1002-6.
   Web of Science ®Google Scholar
• Rösch, D., C. Mügge, V. Fogliano, and L. W. Kroh. 2004. Antioxidant oligomeric proanthocyanidins from sea buckthorn (Hippophae rhamnoides) Pomace. Journal of Agricultural and Food Chemistry 52 (22):6712–8. doi: 10.1021/jf040241g.
   PubMed Web of Science ®Google Scholar
• Rösch, D., M. Bergmann, D. Knorr, and L. W. Kroh. 2003. Structure-antioxidant efficiency relationships of phenolic compounds and their contribution to the antioxidant activity of sea buckthorn juice. Journal of Agricultural and Food Chemistry 51 (15):4233–9. doi: 10.1021/jf0300339.
   PubMed Web of Science ®Google Scholar
• Rossi, J. A., and V. L. Singleton. 1966. Flavor effects and adsorptive properties of purified fractions of grape-seed phenols. American Journal of Enology and Viticulture 17 (4):240–6.
   Google Scholar
• Rotzoll, N., A. Dunkel, and T. Hofmann. 2006. Quantitative studies, taste reconstitution, and omission experiments on the key taste compounds in morel mushrooms (Morchella deliciosa Fr.). Journal of Agricultural and Food Chemistry 54 (7):2705–11. doi: 10.1021/jf053131y.
   PubMed Web of Science ®Google Scholar
• Russell, W., and G. Duthie. 2011. Plant secondary metabolites and gut health: The case for phenolic acids. The Proceedings of the Nutrition Society 70 (3):389–96. doi: 10.1017/S0029665111000152.
   PubMed Web of Science ®Google Scholar
• Russell, W. R., L. Scobbie, A. Chesson, A. J. Richardson, C. S. Stewart, S. H. Duncan, J. E. Drew, and G. G. Duthie. 2008. Anti-inflammatory implications of the microbial transformation of dietary phenolic compounds. Nutrition and Cancer 60 (5):636–42. doi: 10.1080/01635580801987498.
   PubMed Web of Science ®Google Scholar
• Russo, M., C. Spagnuolo, I. Tedesco, S. Bilotto, and G. L. Russo. 2012. The flavonoid quercetin in disease prevention and therapy: Facts and fancies. Biochemical Pharmacology 83 (1):6–15. doi: 10.1016/j.bcp.2011.08.010.
   PubMed Web of Science ®Google Scholar
• Sajfrtová, M., I. Ličková, M. Wimmerová, H. Sovová, and Z. Wimmer. 2010. β-Sitosterol: Supercritical carbon dioxide extraction from sea buckthorn (Hippophae rhamnoides L.) seeds. International Journal of Molecular Sciences 11 (4):1842–50. doi: 10.3390/ijms11041842.
   PubMed Web of Science ®Google Scholar
• Sakurai, T., T. Misaka, M. Ishiguro, K. Masuda, T. Sugawara, K. Ito, T. Kobayashi, S. Matsuo, Y. Ishimaru, T. Asakura, et al. 2010. Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16. The Journal of Biological Chemistry 285 (36):28373–8. doi: 10.1074/jbc.M110.144444.
   PubMed Web of Science ®Google Scholar
• Sawabe, A., and Y. Matsubara. 1999. Bioactive glycosides in citrus fruit peels. In Anonymous studies in plant science, ed. Chong-Ren Yang and Osamu Tanaka, vol. 6 ed., 261–74. Amsterdam: Elsevier Science.
   Google Scholar
• Scharbert, S., and T. Hofmann. 2005. Molecular definition of black tea taste by means of quantitative studies, taste reconstitution, and omission experiments. Journal of Agricultural and Food Chemistry 53 (13):5377–84. doi: 10.1021/jf050294d.
   PubMed Web of Science ®Google Scholar
• Scharbert, S., N. Holzmann, and T. Hofmann. 2004. Identification of the astringent taste compounds in black tea infusions by combining instrumental analysis and human bioresponse. Journal of Agricultural and Food Chemistry 52 (11):3498–508. doi: 10.1021/jf049802u.
   PubMed Web of Science ®Google Scholar
• Schwarz, B., and T. Hofmann. 2007. Sensory-guided decomposition of red currant juice (Ribes rubrum) and structure determination of key astringent compounds. Journal of Agricultural and Food Chemistry 55 (4):1394–404. doi: 10.1021/jf0629078.
   PubMed Web of Science ®Google Scholar
• Seeram, N. P., R. Lee, and D. Heber. 2004. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta; International Journal of Clinical Chemistry 348 (1-2):63–8. doi: 10.1016/j.cccn.2004.04.029.
   PubMed Web of Science ®Google Scholar
• Seglina, D., D. Karklina, S. Ruisa, and I. Krasnova. 2006. The effect of processing on the composition of sea buckthorn juice. Journal of Fruit and Ornamental Plant Research 14:257–64.
   Google Scholar
• Selvamuthukumaran, M., F. Khanum, and A. S. Bawa. 2007. Development of sea buckthorn mixed fruit jelly. International Journal of Food Science & Technology 42 (4):403–10. doi: 10.1111/j.1365-2621.2006.01233.x.
   Web of Science ®Google Scholar
• Setayesh, T., A. Nersesyan, M. Mišík, R. Noorizadeh, E. Haslinger, T. Javaheri, E. Lang, M. Grusch, W. Huber, A. Haslberger, et al. 2019. Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage. European Journal of Nutrition 58 (6):2315–26. doi: 10.1007/s00394-018-1782-2.
   PubMed Web of Science ®Google Scholar
• Sharma, U. K., K. Sharma, N. Sharma, A. Sharma, H. P. Singh, and A. K. Sinha. 2008. Microwave-assisted efficient extraction of different parts of Hippophae rhamnoides for the comparative evaluation of antioxidant activity and quantification of its phenolic constituents by reverse-phase high-performance liquid chromatography (RP-HPLC). Journal of Agricultural and Food Chemistry 56 (2):374–9. doi: 10.1021/jf072510j.
   PubMed Web of Science ®Google Scholar
• Shi, H., J. He, X. Li, J. Han, R. Wu, D. Wang, F. Yang, and E. Sun. 2018. Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. International Immunopharmacology 55:216–22. doi: 10.1016/j.intimp.2017.12.014.
   PubMed Web of Science ®Google Scholar
• Skalski, B., B. Lis, Ł. Pecio, B. Kontek, B. Olas, J. Żuchowski, and A. Stochmal. 2019. Isorhamnetin and its new derivatives isolated from sea buckthorn berries prevent H2O2/Fe—Induced oxidative stress and changes in hemostasis. Food and Chemical Toxicology 125:614–20. doi: 10.1016/j.fct.2019.02.014.
   PubMed Web of Science ®Google Scholar
• Soares, S., E. Brandão, N. Mateus, and V. De Freitas. 2017. Sensorial properties of red wine polyphenols: Astringency and bitterness. Critical Reviews in Food Science and Nutrition 57 (5):937–48. doi: 10.1080/10408398.2014.946468.
   PubMed Web of Science ®Google Scholar
• Soares, S., S. Kohl, S. Thalmann, N. Mateus, W. Meyerhof, and V. De Freitas. 2013. Different phenolic compounds activate distinct human bitter taste receptors. Journal of Agricultural and Food Chemistry 61 (7):1525–33. doi: 10.1021/jf304198k.
   PubMed Web of Science ®Google Scholar
• Stewart, A. J., S. Bozonnet, W. Mullen, G. I. Jenkins, M. E. Lean, and A. Crozier. 2000. Occurrence of flavonols in tomatoes and tomato-based products. Journal of Agricultural and Food Chemistry 48 (7):2663–9. doi: 10.1021/jf000070p.
   PubMed Web of Science ®Google Scholar
• Stobdan, T., G. Korekar, and R. B. Srivastava. 2013. Nutritional attributes and health application of sea buckthorn (Hippophae rhamnoides L.)—A review. Current Nutrition & Food Science 9 (2):151–65. doi: 10.2174/1573401311309020008.
   Google Scholar
• Storlien, L. H., D. E. James, K. M. Burleigh, D. J. Chisholm, and E. W. Kraegen. 1986. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. The American Journal of Physiology 251 (5 Pt 1):E576–83. doi: 10.1152/ajpendo.1986.251.5.E576.
   PubMedGoogle Scholar
• Su, Y. W., E. Tan, J. Zhang, J. L. You, Y. Liu, C. Liu, X. D. Zhou, and Y. Zhang. 2014. Study on three different species tibetan medicine sea buckthorn by 1H-NMR-based metabonomics. Zhongguo Zhong Yao Za Zhi 39 (21):4234–9.
   PubMedGoogle Scholar
• Suomela, J., M. Ahotupa, B. Yang, T. Vasankari, and H. Kallio. 2006. Absorption of flavonols derived from sea buckthorn (Hippophae rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. Journal of Agricultural and Food Chemistry 54 (19):7364–9. doi: 10.1021/jf061889r.
   PubMed Web of Science ®Google Scholar
• Suryakumar, G., and A. Gupta. 2011. Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.). Journal of Ethnopharmacology 138 (2):268–78. doi: 10.1016/j.jep.2011.09.024.
   PubMed Web of Science ®Google Scholar
• Suvanto, J., P. Tähtinen, S. Valkamaa, M. T. Engström, M. Karonen, and J. Salminen. 2018. Variability in foliar ellagitannins of Hippophaë rhamnoides L. and identification of a new ellagitannin, hippophaenin C. Journal of Agricultural and Food Chemistry 66 (3):613–20. doi: 10.1021/acs.jafc.7b04834.
   PubMed Web of Science ®Google Scholar
• Sytařová, I., J. Orsavová, L. Snopek, J. Mlček, Ł. Byczyński, and L. Mišurcová. 2020. Impact of phenolic compounds and vitamins C and E on antioxidant activity of sea buckthorn (Hippophaë rhamnoides L.) berries and leaves of diverse ripening times. Food Chemistry 310:125784. doi: 10.1016/j.foodchem.2019.125784.
   PubMed Web of Science ®Google Scholar
• Tang, X. 2002. Intrinsic change of physical and chemical properties of sea buckthorn (Hippophae rhamnoides) and implications for berry maturity and quality. The Journal of Horticultural Science and Biotechnology 77 (2):177–85. doi: 10.1080/14620316.2002.11511476.
   Web of Science ®Google Scholar
• Tang, X., N. Kälviäinen, and H. Tuorila. 2001. Sensory and hedonic characteristics of juice of sea buckthorn (Hippophae rhamnoides L.) origins and hybrids. LWT - Food Science and Technology 34 (2):102–10. doi: 10.1006/fstl.2000.0751.
   Google Scholar
• Teleszko, M., A. Wojdyło, M. Rudzińska, J. Oszmiański, and T. Golis. 2015. Analysis of lipophilic and hydrophilic bioactive compounds content in sea buckthorn (Hippophaë rhamnoides L.) berries. Journal of Agricultural and Food Chemistry 63 (16):4120–9. doi: 10.1021/acs.jafc.5b00564.
   PubMed Web of Science ®Google Scholar
• Teng, B., Y. Lu, Z. Wang, X. Tao, and D. Wei. 2006. In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells. Pharmacological Research 54 (3):186–94. doi: 10.1016/j.phrs.2006.04.007.
   PubMed Web of Science ®Google Scholar
• Terpou, A., A. Papadaki, L. Bosnea, M. Kanellaki, and N. Kopsahelis. 2019. Novel frozen yogurt production fortified with sea buckthorn berries and probiotics. LWT 105:242–9. doi: 10.1016/j.lwt.2019.02.024.
   Web of Science ®Google Scholar
• Tiitinen, K., M. Vahvaselkä, M. Hakala, S. Laakso, and H. Kallio. 2006. Malolactic fermentation in sea buckthorn (Hippophaë rhamnoides L.) juice processing. European Food Research and Technology 222 (5-6):686–91. doi: 10.1007/s00217-005-0163-2.
   Web of Science ®Google Scholar
• Tiitinen, K., M. Vahvaselkä, S. Laakso, and H. Kallio. 2007. Malolactic fermentation in four varieties of sea buckthorn (Hippophaë rhamnoides L.). European Food Research and Technology 224 (6):725–32. doi: 10.1007/s00217-006-0365-2.
   Web of Science ®Google Scholar
• Tiitinen, K. M., B. Yang, G. G. Haraldsson, S. Jonsdottir, and H. P. Kallio. 2006. Fast analysis of sugars, fruit acids, and vitamin C in sea buckthorn (Hippophaë rhamnoides L.) varieties. Journal of Agricultural and Food Chemistry 54 (7):2508–13. doi: 10.1021/jf053177r.
   PubMed Web of Science ®Google Scholar
• Tiitinen, K. M., M. A. Hakala, and H. P. Kallio. 2005. Quality components of sea buckthorn (Hippophae rhamnoides) varieties. Journal of Agricultural and Food Chemistry 53 (5):1692–9. doi: 10.1021/jf0484125.
   PubMed Web of Science ®Google Scholar
• Tkacz, K., A. Wojdyło, I. P. Turkiewicz, F. Ferreres, D. A. Moreno, and P. Nowicka. 2020. UPLC-PDA-Q/TOF-MS profiling of phenolic and carotenoid compounds and their influence on anticholinergic potential for AChE and BuChE inhibition and on-line antioxidant activity of selected Hippophaë rhamnoides L. cultivars. Food Chemistry 309:125766. doi: 10.1016/j.foodchem.2019.125766.
   PubMed Web of Science ®Google Scholar
• Ursache, F., I. O. Ghinea, M. Turturică, I. Aprodu, G. Râpeanu, and N. Stănciuc. 2017. Phytochemicals content and antioxidant properties of sea buckthorn (Hippophae rhamnoides L.) as affected by heat treatment—Quantitative spectroscopic and kinetic approaches. Food Chemistry 233:442–9. doi: 10.1016/j.foodchem.2017.04.107.
   PubMed Web of Science ®Google Scholar
• Ursin, V. M. 2003. Modification of plant lipids for human health: Development of functional land-based omega-3 fatty acids. The Journal of Nutrition 133 (12):4271–4. doi: 10.1093/jn/133.12.4271.
   PubMed Web of Science ®Google Scholar
• Valentová, H., S. Skrovánková, Z. Panovská, and J. Pokorný. 2002. Time–intensity studies of astringent taste. Food Chemistry 78 (1):29–37. doi: 10.1016/S0308-8146(01)00330-2.
   Web of Science ®Google Scholar
• Verbeke, W. 2006. Functional foods: Consumer willingness to compromise on taste for health? Food Quality and Preference 17 (1-2):126–31. doi: 10.1016/j.foodqual.2005.03.003.
   Web of Science ®Google Scholar
• Walle, T., Y. Otake, U. K. Walle, and F. A. Wilson. 2000. Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. The Journal of Nutrition 130 (11):2658–61. doi: 10.1093/jn/130.11.2658.
   PubMed Web of Science ®Google Scholar
• Wang, Y., L. Zhao, Y. Huo, F. Zhou, W. Wu, F. Lu, X. Yang, X. Guo, P. Chen, Q. Deng, et al. 2016. Protective effect of proanthocyanidins from sea buckthorn (Hippophae rhamnoides L.) seed against visible light-induced retinal degeneration in vivo. Nutrients 8 (5):245. doi: 10.3390/nu8050245.
   Web of Science ®Google Scholar
• Wolffram, S., M. Block, and P. Ader. 2002. Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine. The Journal of Nutrition 132 (4):630–5. doi: 10.1093/jn/132.4.630.
   PubMed Web of Science ®Google Scholar
• Wu, Q., P. A. Kroon, H. Shao, P. W. Needs, and X. Yang. 2018. Differential effects of quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. Journal of Agricultural and Food Chemistry 66 (27):7181–9. doi: 10.1021/acs.jafc.8b02420.
   PubMed Web of Science ®Google Scholar
• Xiao, J., E. Capanoglu, A. R. Jassbi, and A. Miron. 2016. Advance on the flavonoid C-glycosides and health benefits. Critical Reviews in Food Science and Nutrition 56 (sup1):S29–S45. doi: 10.1080/10408398.2015.1067595.
   PubMed Web of Science ®Google Scholar
• Xiao, Y., L. Xin, L. Li, G. Li, X. Shi, G. Ji, J. Mi, and Y. Xie. 2019. Quercetin and kaempferol increase the intestinal absorption of isorhamnetin coexisting in Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) extracts via regulating multidrug resistance-associated protein 2. Phytomedicine 53:154–62. doi: 10.1016/j.phymed.2018.09.028.
   PubMed Web of Science ®Google Scholar
• Xing, J., B. Yang, Y. Dong, B. Wang, J. Wang, and H. P. Kallio. 2002. Effects of sea buckthorn (Hippophae rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia 73 (7-8):644–50. doi: 10.1016/S0367-326X(02)00221-6.
   PubMed Web of Science ®Google Scholar
• Xu, H., Q. Hao, F. Yuan, and Y. Gao. 2015. Nonenzymatic browning criteria to sea buckthorn juice during thermal processing. Journal of Food Process Engineering 38 (1):67–75. doi: 10.1111/jfpe.12128.
   Web of Science ®Google Scholar
• Xu, Y., M. Kaur, R. S. Dhillon, P. S. Tappia, and N. S. Dhalla. 2011. Health benefits of sea buckthorn for the prevention of cardiovascular diseases. Journal of Functional Foods 3 (1):2–12. doi: 10.1016/j.jff.2011.01.001.
   Web of Science ®Google Scholar
• Xue, Y., Q. Miao, A. Zhao, Y. Zheng, Y. Zhang, P. Wang, H. Kallio, and B. Yang. 2015. Effects of sea buckthorn (Hippophaë rhamnoides) juice and L-quebrachitol on Type 2 diabetes mellitus in db/db mice. Journal of Functional Foods 16:223–33. doi: 10.1016/j.jff.2015.04.041.
   Web of Science ®Google Scholar
• Yang, B. 2001. Lipophilic components of sea buckthorn (Hippophaë rhamnoides) seeds and berries and physiological effects of sea buckthorn oils. PhD diss., University of Turku.
   Google Scholar
• Yang, B. 2009. Sugars, acids, ethyl β-D-glucopyranose and a methyl inositol in sea buckthorn (Hippophae rhamnoides) berries. Food Chemistry 112 (1):89–97. doi: 10.1016/j.foodchem.2008.05.042.
   Web of Science ®Google Scholar
• Yang, B., and H. Kallio. 2002. Composition and physiological effects of sea buckthorn (Hippophaë) lipids. Trends in Food Science & Technology 13 (5):160–7. doi: 10.1016/S0924-2244(02)00136-X.
   Web of Science ®Google Scholar
• Yang, B., and H. P. Kallio. 2001. Fatty acid composition of lipids in sea buckthorn (Hippophaë rhamnoides L.) berries of different origins. Journal of Agricultural and Food Chemistry 49 (4):1939–47. doi: 10.1021/jf001059s.
   PubMed Web of Science ®Google Scholar
• Yang, B., H. Liu, J. Yang, V. K. Gupta, and Y. Jiang. 2018. New insights on bioactivities and biosynthesis of flavonoid glycosides. Trends in Food Science & Technology 79:116–24. doi: 10.1016/j.tifs.2018.07.006.
   Web of Science ®Google Scholar
• Yang, B., M. Ahotupa, P. Määttä, and H. Kallio. 2011. Composition and antioxidative activities of supercritical CO2-extracted oils from seeds and soft parts of northern berries. Food Research International 44 (7):2009–17. doi: 10.1016/j.foodres.2011.02.025.
   Web of Science ®Google Scholar
• Yang, B., and M. Kortesniemi. 2015. Clinical evidence on potential health benefits of berries. Current Opinion in Food Science 2:36–42. doi: 10.1016/j.cofs.2015.01.002.
   Web of Science ®Google Scholar
• Yang, B., R. M. Karlsson, P. H. Oksman, and H. P. Kallio. 2001. Phytosterols in sea buckthorn (Hippophaë rhamnoides L.) berries: Identification and effects of different origins and harvesting times. Journal of Agricultural and Food Chemistry 49 (11):5620–9. doi: 10.1021/jf010813m.
   PubMed Web of Science ®Google Scholar
• Yang, B., T. Halttunen, O. Raimo, K. Price, and H. Kallio. 2009. Flavonol glycosides in wild and cultivated berries of three major subspecies of Hippophaë rhamnoides and changes during harvesting period. Food Chemistry 115 (2):657–64. doi: 10.1016/j.foodchem.2008.12.073.
   Web of Science ®Google Scholar
• Yang, J. H., B. Y. Shin, J. Y. Han, M. G. Kim, J. E. Wi, Y. W. Kim, I. J. Cho, S. C. Kim, S. M. Shin, and S. H. Ki. 2014. Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. Toxicology and Applied Pharmacology 274 (2):293–301. doi: 10.1016/j.taap.2013.10.026.
   PubMed Web of Science ®Google Scholar
• Yang, J. H., S. C. Kim, B. Y. Shin, S. H. Jin, M. J. Jo, K. H. Jegal, Y. W. Kim, J. R. Lee, S. K. Ku, I. J. Cho, et al. 2013. O-methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation. Food and Chemical Toxicology 59:362–72. doi: 10.1016/j.fct.2013.05.049.
   PubMed Web of Science ®Google Scholar
• Yang, W., O. Laaksonen, H. Kallio, and B. Yang. 2016. Proanthocyanidins in sea buckthorn (Hippophaë rhamnoides L.) berries of different origins with special reference to the influence of genetic background and growth location. Journal of Agricultural and Food Chemistry 64 (6):1274–82. doi: 10.1021/acs.jafc.5b05718.
   PubMed Web of Science ®Google Scholar
• Yang, W., O. Laaksonen, H. Kallio, and B. Yang. 2017. Effects of latitude and weather conditions on proanthocyanidins in berries of Finnish wild and cultivated sea buckthorn (Hippophaë rhamnoides L. ssp. rhamnoides). Food Chemistry 216:87–96. doi: 10.1016/j.foodchem.2016.08.032.
   PubMed Web of Science ®Google Scholar
• Zadernowski, R., M. Naczk, and R. Amarowicz. 2003. Tocopherols in sea buckthorn (Hippophae rhamnoides L.) berry oil. Journal of the American Oil Chemists' Society 80 (1):55–8. doi: 10.1007/s11746-003-0650-z.
   Web of Science ®Google Scholar
• Zadernowski, R., M. Naczk, S. Czaplicki, M. Rubinskiene, and M. Szałkiewicz. 2005. Composition of phenolic acids in sea buckthorn (Hippophae rhamnoides L.) berries. Journal of the American Oil Chemists' Society 82 (3):175–9. doi: 10.1007/s11746-005-5169-1.
   Web of Science ®Google Scholar
• Zang, Y., L. Zhang, K. Igarashi, and C. Yu. 2015. The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice. Food & Function 6 (3):834–41. doi: 10.1039/c4fo00844h.
   PubMed Web of Science ®Google Scholar
• Zheng, J., H. Kallio, K. Linderborg, and B. Yang. 2011. Sugars, sugar alcohols, fruit acids, and ascorbic acid in wild Chinese sea buckthorn (Hippophae rhamnoides ssp sinensis) with special reference to influence of latitude and altitude. Food Research International 44 (7):2018–26. doi: 10.1016/j.foodres.2010.10.007.
   Web of Science ®Google Scholar
• Zheng, J., H. Kallio, and B. Yang. 2016. Sea buckthorn (Hippophaë rhamnoides ssp. rhamnoides) berries in Nordic environment: Compositional response to latitude and weather conditions. Journal of Agricultural and Food Chemistry 64 (24):5031–44. doi: 10.1021/acs.jafc.6b00682.
   PubMed Web of Science ®Google Scholar
• Zheng, J., B. Yang, M. Trepanier, and H. Kallio. 2012. Effects of genotype, latitude, and weather conditions on the composition of sugars, sugar alcohols, fruit acids, and ascorbic acid in sea buckthorn (Hippophaë rhamnoides ssp. mongolica) berry juice. Journal of Agricultural and Food Chemistry 60 (12):3180–9. doi: 10.1021/jf204577g.
   PubMed Web of Science ®Google Scholar
• Zvaigzne, G. 2018. Effect of UHT processing on the bioactive compounds and antioxidant capacity in orange and sea buckthorn juices. PhD diss., Latvia University of Life Sciences and Technologies.
   Google Scholar