476
Views
2
CrossRef citations to date
0
Altmetric
Reviews

Food-derived natural compounds in the management of chronic diseases via Wnt signaling pathway

, , , &

References

  • Adamian, A. A., S. V. Dobysh, L. E. Kilimchuk, I. N. Shandurenko, and I. A. Chekmareva. 2004. Development of new biologically active dressings and methodology of their use. Khirurgiia 12:10–4.
  • Afrin, S., F. Giampieri, M. Gasparrini, T. Y. Forbes-Hernández, D. Cianciosi, P. Reboredo-Rodriguez, J. Zhang, P. P. Manna, M. Daglia, A. G. Atanasov, et al. 2020. Dietary phytochemicals in colorectal cancer prevention and treatment: a focus on the molecular mechanisms involved. Biotechnology Advances 38:107322. doi: 10.1016/j.biotechadv.2018.11.011.
  • Ahmed, F. E., and P. C. Health. 2004. Effect of diet, life style, and other environmental/chemopreventive factors on colorectal cancer development, and assessment of the risks. Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews 22 (2):91–148.
  • Alumkal, J. J., R. Slottke, J. Schwartzman, G. Cherala, M. Munar, J. N. Graff, T. M. Beer, C. W. Ryan, D. R. Koop, A. Gibbs, et al. 2015. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Investigational New Drugs 33 (2):480–9. doi: 10.1007/s10637-014-0189-z.
  • Anastas, J. N., and R. T. Moon. 2013. WNT signalling pathways as therapeutic targets in cancer. Nature Reviews Cancer 13 (1):11–26.
  • Arai, Y., S. Watanabe, M. Kimira, K. Shimoi, R. Mochizuki, and N. Kinae. 2000. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. The Journal of Nutrition 130 (9):2243–50. doi: 10.1093/jn/130.9.2243.
  • Azmi, L., I. Shukla, A. Goutam, C. V. Rao, T. Jawaid, M. Kamal, A. S. Awaad, S. I. Alqasoumi, and O. A. AlKhamees. 2019. In vitro wound healing activity of 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde (HDNC) and other isolates of Aegle marmelos L.: Enhances keratinocytes motility via Wnt/β-catenin and RAS-ERK pathways. Saudi Pharmaceutical Journal 27 (4):532–9.
  • Bachmann, I. M., O. Straume, H. E. Puntervoll, M. B. Kalvenes, and L. A. Akslen. 2005. Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma . Clinical Cancer Research11 (24 Pt 1):8606–14. doi: 10.1158/1078-0432.CCR-05-0011.
  • Bai, J., J. Wu, R. Tang, C. Sun, J. Ji, Z. Yin, G. Ma, and W. Yang. 2020. Emodin, a natural anthraquinone, suppresses liver cancer in vitro and in vivo by regulating VEGFR 2 and miR-34a. Investigational New Drugs 38 (2):229–45. doi: 10.1007/s10637-019-00777-5.
  • Bankaitis, E. D., A. Ha, C. J. Kuo, and S. T. Magness. 2018. Reserve stem cells in intestinal homeostasis and injury. Gastroenterology 155 (5):1348–61. doi: 10.1053/j.gastro.2018.08.016.
  • Barker, N., J. H. van Es, J. Kuipers, P. Kujala, M. van den Born, M. Cozijnsen, A. Haegebarth, J. Korving, H. Begthel, P. J. Peters, et al. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449 (7165):1003–7. doi: 10.1038/nature06196.
  • Baron, R., and M. Kneissel. 2013. WNT signaling in bone homeostasis and disease: From human mutations to treatments. Nature Medicine 19 (2):179–92. doi: 10.1038/nm.3074.
  • Bastakoty, D., and P. P. Young. 2016. Wnt/β-catenin pathway in tissue injury: Roles in pathology and therapeutic opportunities for regeneration. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 30 (10):3271–84. doi: 10.1096/fj.201600502R.
  • Basu, S., B. Ellinger, S. Rizzo, C. Deraeve, M. Schürmann, H. Preut, H.-D. Arndt, and H. Waldmann. 2011. Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway. Proceedings of the National Academy of Sciences 108 (17):6805–10. doi: 10.2307/41242083.
  • Benham-Pyle, B. W., B. L. Pruitt, and W. J. Nelson. 2015. Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry . Science (New York, N.Y.) 348 (6238):1024–7. doi: 10.1126/science.aaa4559..
  • Bhatia, D., R. J. Thoppil, A. Mandal, K. A. Samtani, A. S. Darvesh, and A. Bishayee. 2013. Pomegranate bioactive constituents suppress cell proliferation and induce apoptosis in an experimental model of hepatocellular carcinoma: Role of Wnt/β-catenin signaling pathway. Evidence-Based Complementary and Alternative Medicine 80:16. doi: 10.1055/s-0034-1395108.
  • Bingling, D., Y. Ma, T. Yang, M. Fan, R. Yu, Q. Su, H. Wang, F. Liu, C. Yang, and Y. Zhang. 2019. Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma. Phytotherapy Research: PTR 33 (3):745–55. doi: 10.1002/ptr.6267.
  • Bolon, B. 2012. Cellular and molecular mechanisms of autoimmune disease. Toxicologic Pathology 40 (2):216–29. doi: 10.1177/0192623311428481.
  • Bourhis, E., W. Wang, C. Tam, J. Hwang, Y. Zhang, D. Spittler, O. W. Huang, Y. Gong, A. Estevez, I. Zilberleyb, et al. 2011. Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Structure (London, England: 1993) 19 (10):1433–42. doi: 10.1016/j.str.2011.07.005.
  • Bushra, R., N. Aslam, and A. Y. Khan. 2011. Food-drug interactions. Oman Medical Journal 26 (2):77–83. doi: 10.5001/omj.2011.21.
  • Calviello, G., F. Resci, S. Serini, E. Piccioni, A. Toesca, A. Boninsegna, G. Monego, F. O. Ranelletti, and P. Palozza. 2007. Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2 . Carcinogenesis 28 (6):1202–9. doi: 10.1016/j.jnutbio.2009.02.009.
  • Chattopadhyay, S., and R. T. Raines. 2014. Review collagen-based biomaterials for wound healing . Biopolymers 101 (8):821–33. doi: 10.1002/bip.22486.
  • Chen, J., and F. Long. 2013. β-Catenin promotes bone formation and suppresses bone resorption in postnatal growing mice. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research 28 (5):1160–9. doi: 10.1002/jbmr.1834.
  • Chen, S., and G. Parmigiani. 2007. Meta-analysis of BRCA1 and BRCA2 penetrance. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 25 (11):1329–33. doi: 10.1200/JCO.2006.09.1066.
  • Chen, T. X., X. Y. Cheng, Y. Wang, and W. Yin. 2018. Toosendanin inhibits adipogenesis by activating Wnt/β-catenin signaling. Scientific Reports 8 (1):4626. doi: 10.1038/s41598-018-22873-x.
  • Chen, X., L.-H. Peng, N. Li, Q.-M. Li, P. Li, K.-P. Fung, P.-C. Leung, and J.-Q. Gao. 2012. The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo. Journal of Ethnopharmacology 139 (3):721–7. doi: 10.1016/j.jep.2011.11.035.
  • Chen, Y., Z.-Y. Chen, L. Chen, J.-Y. Zhang, L.-Y. Fu, L. Tao, Y. Zhang, X.-X. Hu, and X.-C. Shen. 2019. Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling. Biochemical Pharmacology 166:33–45. doi: 10.1016/j.bcp.2019.05.001.
  • Chien, A. J., E. C. Moore, A. S. Lonsdorf, R. M. Kulikauskas, B. G. Rothberg, A. J. Berger, M. B. Major, S. T. Hwang, D. L. Rimm, and R. T. Moon. 2009. Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model . Proceedings of the National Academy of Sciences of the United States of America 106 (4):1193–8. doi: 10.1073/pnas.0811902106.
  • Chiu, C.-S., C.-H. Tsai, M.-S. Hsieh, S.-C. Tsai, Y.-J. Jan, W.-Y. Lin, D.-W. Lai, S.-M. Wu, H.-Y. Hsing, J. L. Arbiser, et al. 2019. Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways. Cancer Letters 442:113–25. doi: 10.1016/j.canlet.2018.10.026.
  • Cho, S. W., J.-Y. Yang, H. J. Sun, J. Y. Jung, S. J. Her, H. Y. Cho, H. J. Choi, S. W. Kim, S. Y. Kim, and C. S. Shin. 2009. Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells. Bone 44 (6):1069–77. doi: 10.1016/j.bone.2009.02.012.
  • Church, V. L., and P. Francis-West. 2004. Wnt signalling during limb development. International Journal of Developmental Biology 46 (7):927–36. doi: 10.1079/IVP2001258.
  • Cici, D., A. Corrado, C. Rotondo, and F. P. Cantatore. 2019. Wnt signaling and biological therapy in rheumatoid arthritis and spondyloarthritis. International Journal of Molecular Sciences 20 (22):5552. doi: 10.3390/ijms20225552.
  • Clevers, H., K. M. Loh, and R. Nusse. 2014. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science (New York, N.Y.) 346 (6205):1248012. doi: 10.1126/science.1248012.
  • Clevers, H., and R. Nusse. 2012. Wnt/β-catenin signaling and disease. Cell 149 (6):1192–205. doi: 10.1016/j.cell.2012.05.012.
  • Cruz-Lozano, M., A. González-González, J. A. Marchal, E. Muñoz-Muela, M. P. Molina, F. E. Cara, A. M. Brown, G. García-Rivas, C. Hernández-Brenes, J. A. Lorente, et al. 2019. Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways. European Journal of Nutrition 58 (8):3207–19. doi: 10.1007/s00394-018-1864-1.
  • Davis, J. E., and D. Hastings. 2018. Transcriptional regulation of TCF/LEF and PPARγ by daidzein and genistein in 3T3-L1 preadipocytes. Journal of Medicinal Food 21 (8):761–8. doi: 10.1089/jmf.2017.0136.
  • de Freitas, R. A., M. F. Drenski, A. M. Alb, and W. F. Reed. 2010. Characterization of stability, aggregation, and equilibrium properties of modified natural products; The case of carboxymethylated chitosans. Materials Science and Engineering: C 30 (1):34–41. doi: 10.1016/j.msec.2009.08.005.
  • de Oliveira, F. C., J. S. d R. Coimbra, E. B. de Oliveira, A. D. G. Zuñiga, and E. E. G. Rojas. 2016. Food protein–polysaccharide conjugates obtained via the Maillard reaction: A review. Critical Reviews in Food Science and Nutrition 56 (7):1108–25. doi: 10.1080/10408398.2012.755669.
  • Dong, G. Z., S. Y. Lee, H. Y. Zhao, Y. I. Lee, J. H. Jeong, R. Jeon, H. J. Lee, and J. H. Ryu. 2015. Diarylheptanoids from lesser galangal suppress human colon cancer cell growth through modulating Wnt/β-catenin pathway. Journal of Functional Foods 18:47–57. doi: 10.1016/j.jff.2015.06.059.
  • Dontu, G., M. Al-Hajj, W. M. Abdallah, M. F. Clarke, and M. S. Wicha. 2003. Stem cells in normal breast development and breast cancer. Cell Proliferation 36:59–72. doi: 10.1046/j.1365-2184.36.s.1.6.x.
  • Du, L., M.-N. Nong, J.-M. Zhao, X.-M. Peng, S.-H. Zong, and G.-F. Zeng. 2016. Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt/β-catenin signalling pathway. Scientific Reports 6 (1):32261–12. doi: 10.1038/srep32261.
  • Du Toit-Kohn, J.-L., L. Louw, and A.-M. Engelbrecht. 2009. Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. The Journal of Nutritional Biochemistry 20 (2):106–14. doi: 10.1016/j.jnutbio.2007.12.005.
  • Duchartre, Y., Y.-M. Kim, and M. Kahn. 2016. The Wnt signaling pathway in cancer. Critical Reviews in Oncology/Hematology 99:141–9. doi: 10.1016/j.critrevonc.2015.12.005.
  • Dujic, T., Causevic, A. T. Bego, M. Malenica, Z. Velija‐Asimi, E. Pearson, and S. Semiz. 2016. Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes. Diabetic Medicine: A Journal of the British Diabetic Association 33 (4):511–4. doi: 10.1111/dme.13040.
  • Ferlay, J., I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray. 2015. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer 136 (5):E359–E86. doi: 10.1002/ijc.29210.
  • Fiorentini, D., L. Zambonin, F. Vieceli Dalla Sega, and S. Hrelia. 2015. Polyphenols as modulators of aquaporin family in health and disease. Oxidative Medicine and Cellular Longevity 2015:196914–8. doi: 10.1155/2015/196914.
  • Fodde, R., and T. Brabletz. 2007. Wnt/beta-catenin signaling in cancer stemness and malignant behavior . Current Opinion in Cell Biology 19 (2):150–8. doi: 10.1016/j.ceb.2007.02.007.
  • Fogliano, V., and P. Vitaglione. 2005. Functional foods: Planning and development. Molecular Nutrition & Food Research 49 (3):256–62. doi: 10.1002/mnfr.200400067.
  • Fu, Y., H. Chang, X. Peng, Q. Bai, L. Yi, Y. Zhou, J. Zhu, and M. Mi. 2014. Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathway. PloS One 9 (7):e102535. doi: 10.1371/journal.pone.0102535.
  • Fuentes, R. G., M. A. Arai, and M. Ishibashi. 2015. Natural compounds with Wnt signal modulating activity. Natural Product Reports 32 (12):1622–8. doi: 10.1039/C5NP00074B.
  • Fujii, N., L. You, Z. Xu, K. Uematsu, J. Shan, B. He, I. Mikami, L. R. Edmondson, G. Neale, J. Zheng, et al. 2007. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Research 67 (2):573–9. doi: 10.1158/0008-5472.
  • Fujiki, H., E. Sueoka, A. Rawangkan, and M. Suganuma. 2017. Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate. Journal of Cancer Research and Clinical Oncology 143 (12):2401–12. doi: 10.1007/s00432-017-2515-2.
  • Fung, T. T., F. B. Hu, K. Wu, S. E. Chiuve, C. S. Fuchs, and E. Giovannucci. 2010. The Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets and colorectal cancer. The American Journal of Clinical Nutrition 92 (6):1429–35. doi: 10.3945/ajcn.2010.29242.
  • Gallagher, S. J., F. Rambow, M. Kumasaka, D. Champeval, A. Bellacosa, V. Delmas, and L. Larue. 2013. Beta-catenin inhibits melanocyte migration but induces melanoma metastasis. Oncogene 32 (17):2230–8. doi: 10.1038/onc.2012.229.
  • Gao, L., N. Gou, E. Yuan, and J. Ren. 2020. Bioactivity-oriented purification of polyphenols from Cinnamomum cassia Presl. with anti-proliferation effects on colorectal cancer cells. Plant Foods for Human Nutrition (Dordrecht, Netherlands) 75 (4):561–8. doi: 10.1007/s11130-020-00846-8.
  • Gao, Z., Z. Xu, M.-S. Hung, Y.-C. Lin, T. Wang, M. Gong, X. Zhi, D. M. Jablon, and L. You. 2009. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Research 29 (6):2025–30. doi: 10.1016/j.jtcvs.2009.05.043.
  • George, V. C., G. Dellaire, and H. V. Rupasinghe. 2017. Plant flavonoids in cancer chemoprevention: Role in genome stability. The Journal of Nutritional Biochemistry 45:1–14. doi: 10.1016/j.jnutbio.2016.11.007.
  • Gibellini, L., M. Pinti, M. Nasi, J. P. Montagna, S. De Biasi, E. Roat, L. Bertoncelli, E. L. Cooper, and A. Cossarizza. 2011. Quercetin and cancer chemoprevention. Evidence-Based Complementary and Alternative Medicine: eCAM 2011 (3):591356. doi: 10.1093/ecam/neq053.
  • Giles, R. H., J. H. Van Es, and H. Clevers. 2003. Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica et Biophysica Acta (Bba) – Reviews on Cancer 1653 (1):1–24. doi: 10.1016/S0304-419X(03)00005-2.
  • Gillette-Guyonnet, S., Secher, M., and B. Vellas. 2013. Nutrition and neurodegeneration: Epidemiological evidence and challenges for future research. British Journal of Clinical Pharmacology 75 (3):738–55. doi: 10.1111/bcp.12058.
  • Gödeke, J., S. Maier, M. Eichenmüller, J. Müller-Höcker, D. von Schweinitz, and R. Kappler. 2013. Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1. Nutrition and Cancer 65 (8):1200–7. doi: 10.1080/01635581.2013.828085.
  • Gong, E. J., H. R. Park, M. E. Kim, S. Piao, E. Lee, D.-G. Jo, H. Y. Chung, N.-C. Ha, M. P. Mattson, and J. Lee. 2011. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiology of Disease 44 (2):223–30. doi: 10.1016/j.nbd.2011.07.005.
  • Groden, J., A. Thliveris, W. Samowitz, M. Carlson, L. Gelbert, H. Albertsen, G. Joslyn, J. Stevens, L. Spirio, and M. Robertson. 1991. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66 (3):589–600. doi: 10.1016/0092-8674(81)90021-0.
  • Gu, H.-F., X.-Y. Mao, and M. Du. 2019. Prevention of breast cancer by dietary polyphenols—Role of cancer stem cells. Critical Reviews in Food Science Nutrition 1–16. doi: 10.1080/10408398.2018.1551778.
  • Gu, J., C.-F. Cui, L. Yang, L. Wang, and X.-H. Jiang. 2019. Emodin inhibits colon cancer cell invasion and migration by suppressing epithelial–mesenchymal transition via the Wnt/β-catenin pathway . Oncology Research 27 (2):193–202. doi: 10.3727/096504018X15150662230295.
  • Guo, D., H. He, M. Zhao, G. Zhang, and T. Hou. 2020. Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway. Journal of Food Science 85 (3):834–42. doi: 10.1111/1750-3841.15067.
  • Guo, X., and X.-F. Wang. 2009. Signaling cross-talk between TGF-beta/BMP and other pathways . Cell Research 19 (1):71–88. doi: 10.1038/cr.2008.302.
  • He, T.-C., A. B. Sparks, C. Rago, H. Hermeking, L. Zawel, L. T. Da Costa, P. J. Morin, B. Vogelstein, and K. W. Kinzler. 1998. Identification of c-MYC as a target of the APC pathway. Science (New York, N.Y.) 281 (5382):1509–12. doi: 10.1126/science.281.5382.1509.
  • Hornero-Méndez, D., and M. I. Mínguez-Mosquera. 2007. Bioaccessibility of carotenes from carrots: Effect of cooking and addition of oil. Innovative Food Science & Emerging Technologies 8 (3):407–12. doi: 10.1016/j.ifset.2007.03.014.
  • Hou, Q., Y. Dong, Q. Yu, B. Wang, S. Le, Y. Guo, and B. Zhang. 2020. Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function . FASEB Journal 34 (8):10299–315. doi: 10.1096/fj.201902573RR.
  • Hseu, Y. C., G. R. Chang, J. Y. Pan, P. Rajendran, D. C. Mathew, M. L. Li, J. W. Liao, W. T. L. Chen, and H. L. Yang. 2019. Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers . Journal of Cellular Physiology 234 (4):4125–39. doi: 10.1002/jcp.27222.
  • Hu, F., Y. Yan, C.-W. Wang, Y. Liu, J.-J. Wang, F. Zhou, Q.-H. Zeng, X. Zhou, J. Chen, A.-J. Wang, et al. 2019. Article effect and mechanism of Ganoderma lucidum polysaccharides on human fibroblasts and skin wound healing in mice. Chinese Journal of Integrative Medicine 25 (3):203–9. doi: 10.1007/s11655-018-3060-9.
  • Huang, Y.-C., K.-C. Liu, and Y.-L. Chiou. 2012. Melanogenesis of murine melanoma cells induced by hesperetin, a citrus hydrolysate-derived flavonoid. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 50 (3–4):653–9. doi: 10.1016/j.fct.2012.01.012.
  • Jaiswal, A. S., B. P. Marlow, N. Gupta, and S. Narayan. 2002. Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21 (55):8414–27. doi: 10.1038/sj.onc.1205947.
  • Janda, C. Y., D. Waghray, A. M. Levin, C. Thomas, and K. C. Garcia. 2012. Structural basis of Wnt recognition by Frizzled. Science (New York, N.Y.) 337 (6090):59–64. doi: 10.1126/science.1222879.
  • Jang, Y. J., H. J. Son, J. Ahn, C. H. Jung, and T. Ha. 2016. Coumestrol modulates Akt and Wnt/β-catenin signaling during the attenuation of adipogenesis. Food & Function 7 (12):4984–91. doi: 10.1039/c6fo01127f.
  • Ji, H., K. Ahn, H. Cho, H-e Kim, Y. Kim, and O. Kim. 2018. Sanguisorba officinalis L. extracts activate Wnt/β-catenin pathway, and subsequently control adipo-osteogenic differentiation. Biochemical and Biophysical Research Communications 504 (1):352–8. doi: 10.1016/j.bbrc.2018.08.196.
  • Jiang, T., R. C.-C. Chang, H. Rosenmann, and J.-T. Yu. 2015. Advances in Alzheimer’s disease: From bench to bedside: Hindawi. [. Mismatch][Mismatch 2015:1–2.
  • Jin, G. R., Y. L. Zhang, J. Yap, W. A. Boisvert, and B. H. Lee. 2020. Hair growth potential of Salvia plebeia extract and its associated mechanisms. Pharmaceutical Biology 58 (1):400–9. doi: 10.1080/13880209.2020.1759654.
  • Jin, N., H. Zhu, X. Liang, W. Huang, Q. Xie, P. Xiao, J. Ni, and Q. Liu. 2017. Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease. Experimental Neurology 297:36–49. doi: 10.1016/j.expneurol.2017.07.006.
  • Jing, H., X. Su, B. Gao, Y. Shuai, J. Chen, Z. Deng, L. Liao, and Y. Jin. 2018. Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis. Cell Death & Disease 9 (2):176. doi: 10.1038/s41419-017-0231-0.
  • Kageshita, T., C. V. Hamby, T. Ishihara, K. Matsumoto, T. Saida, and T. Ono. 2001. Loss of beta-catenin expression associated with disease progression in malignant melanoma . The British Journal of Dermatology 145 (2):210–6. doi: 10.1046/j.1365-2133.2001.04336.x.
  • Kakarala, M., D. E. Brenner, H. Korkaya, C. Cheng, K. Tazi, C. Ginestier, S. Liu, G. Dontu, and M. S. Wicha. 2010. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Research and Treatment 122 (3):777–85. doi: 10.1007/s10549-009-0612-x.
  • Kang, J.-I., M.-K. Kim, J.-H. Lee, Y.-J. Jeon, E.-K. Hwang, Y.-S. Koh, J.-W. Hyun, S.-Y. Kwon, E.-S. Yoo, and H.-K. Kang. 2017. Undariopsis peterseniana promotes hair growth by the activation of Wnt/β-catenin and ERK pathways. Marine Drugs 15 (5):130. doi: 10.3390/md15050130.
  • Kang, Q., J. Gong, M. Wang, Q. Wang, F. Chen, and K.-W. Cheng. 2019. 6-C-(E-phenylethenyl) naringenin attenuates the stemness of hepatocellular carcinoma cells by suppressing Wnt/β-catenin signaling. Journal of Agricultural and Food Chemistry 67 (50):13939–47. doi: 10.1021/acs.jafc.0c00226.
  • Karataş, A., C. Orhan, M. Tuzcu, N. Şahin, İ. H. Özercan, S. S. Koca, V. Juturu, and K. Şahin. 2020. Mango ginger (Curcuma amada) inhibits collagen-induced arthritis by modulating inflammatory cytokine levels in rats. Turkish Journal of Medical Sciences 50 (8):2040–7. doi: 10.3906/sag-2004-105.
  • Emami, K. H., C. Nguyen, H. Ma, D. H. Kim, K. W. Jeong, M. Eguchi, R. T. Moon, J.-L. Teo, S. W. Oh, H. Y. Kim, et al. 2004. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription . Proceedings of the National Academy of Sciences of the United States of America 101 (34):12682–7. doi: 10.1073/pnas.0404875101.
  • Kavitha, K., J. Kowshik, T. K. K. Kishore, A. B. Baba, and S. Nagini. 2013. Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer. Biochimica et Biophysica Acta 1830 (10):4433–44. doi: 10.1016/j.bbagen.2013.05.032.
  • Khan, N., F. Afaq, and H. Mukhtar. 2008. Cancer chemoprevention through dietary antioxidants: Progress and promise. Antioxidants & Redox Signaling 10 (3):475–510. doi: 10.1089/ars.2007.1740.
  • Kim, J., X. Zhang, K. M. Rieger-Christ, I. C. Summerhayes, D. E. Wazer, K. E. Paulson, and A. S. Yee. 2006. Suppression of Wnt signaling by the green tea compound (−)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1 . The Journal of Biological Chemistry 281 (16):10865–75. doi: 10.1074/jbc.M513378200.
  • Kim, M.-B., Y. Song, C. Kim, and J.-K. Hwang. 2014. Kirenol inhibits adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 445 (2):433–8. doi: 10.1016/j.bbrc.2014.02.017.
  • Kim, Y. E., H. C. Choi, I.-C. Lee, D. Y. Yuk, H. Lee, and B. Y. Choi. 2016. 3-Deoxysappanchalcone promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice by modulating Wnt/β-catenin and STAT signaling. Biomolecules & Therapeutics 24 (6):572–80. doi: 10.4062/biomolther.2016.183.
  • Klinge, C. M., K. A. Blankenship, K. E. Risinger, S. Bhatnagar, E. L. Noisin, W. K. Sumanasekera, L. Zhao, D. M. Brey, and R. S. Keynton. 2005. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. The Journal of Biological Chemistry 280 (9):7460–8. doi: 10.1074/jbc.M411565200.
  • Kosinski, C., V. S. W. Li, A. S. Y. Chan, J. Zhang, C. Ho, W. Y. Tsui, T. L. Chan, R. C. Mifflin, D. W. Powell, S. T. Yuen, et al. 2007. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proceedings of the National Academy of Sciences of the United States of America 104 (39):15418–23. doi: 10.1073/pnas.0707210104.
  • Koval, A., C. A. Pieme, E. F. Queiroz, S. Ragusa, K. Ahmed, A. Blagodatski, J.-L. Wolfender, T. V. Petrova, and V. L. Katanaev. 2018. Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts. Cancer Letters 435:110–20. doi: 10.1016/j.canlet.2018.08.003.
  • Kramer, I., C. Halleux, H. Keller, M. Pegurri, J. H. Gooi, P. B. Weber, J. Q. Feng, L. F. Bonewald, and M. Kneissel. 2010. Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis . Molecular and Cellular Biology 30 (12):3071–85. doi: 10.1128/MCB.01428-09.
  • Kumar, A., A. K. Pandurangan, F. Lu, H. Fyrst, M. Zhang, H.-S. Byun, R. Bittman, and J. D. Saba. 2012. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer. Carcinogenesis 33 (9):1726–35. doi: 10.1093/carcin/bgs174.
  • Kwack, M. H., B. M. Kang, M. K. Kim, J. C. Kim, and Y. K. Sung. 2011. Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect. Journal of Dermatological Science 62 (3):154–9. doi: 10.1016/j.jdermsci.2011.01.013.
  • Lai, C. S., J. C. Wu, S. F. Yu, V. Badmaev, K. Nagabhushanam, C. T. Ho, and M. H. Pan. 2011. Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis . Molecular Nutrition & Food Research 55 (12):1819–28. doi: 10.1002/mnfr.201100290.
  • Larriba, M., J. González-Sancho, A. Barbáchano, N. Niell, G. Ferrer-Mayorga, and A. Muñoz. 2013. Vitamin D is a multilevel repressor of Wnt/b-catenin signaling in cancer cells. Cancers 5 (4):1242–60. doi: 10.3390/cancers5041242.
  • Lee, H., S. Bae, K. Kim, W. Kim, S.-I. Chung, Y. Yang, and Y. Yoon. 2011. Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway. Life Sciences 88 (7–8):294–301. doi: 10.1016/j.lfs.2010.12.004.
  • Lee, H., S. Bae, Y. S. Kim, and Y. Yoon. 2011. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum. Life Sciences 89 (11–12):388–94. doi: 10.1016/j.lfs.2011.07.006.
  • Lee, J., J.-Y. Imm, and S.-H. Lee. 2017. β-catenin mediates anti-adipogenic and anticancer effects of arctigenin in preadipocytes and breast cancer cells. Journal of Agricultural and Food Chemistry 65 (12):2513–20. doi: 10.1021/acs.jafc.7b00112.
  • Lee, K.-H., S. L. Morris-Natschke, X. Yang, R. Huang, T. Zhou, S.-F. Wu, Q. Shi, and H. Itokawa. 2012. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. Journal of Traditional and Complementary Medicine 2 (2):1–12. doi: 10.1016/S2225-4110(16)30081-5.
  • Lee, M.-A., W. K. Kim, H. J. Park, S. S. Kang, and S. K. Lee. 2013. Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells. Bioorganic & Medicinal Chemistry Letters 23 (20):5511–4. doi: 10.1016/j.bmcl.2013.08.065.
  • Leow, P.-C., P. Bahety, C. P. Boon, C. Y. Lee, K. L. Tan, T. Yang, and P.-L R. Ee. 2014. Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. European Journal of Medicinal Chemistry 71:67–80. doi: 10.1016/j.ejmech.2013.10.073.
  • Li, F.-L., X. Li, Y.-F. Wang, X.-L. Xiao, R. Xu, J. Chen, B. Fan, W.-B. Xu, L. Geng, and B. Li. 2012. Astragaloside IV downregulates β-catenin in rat keratinocytes to counter LiCl-induced inhibition of proliferation and migration. Evidence-Based Complementary Alternative Medicine 2012 (10):1–12. doi: 10.1155/2012/956107.
  • Li, J., L. Hu, T. Zhou, X. Gong, R. Jiang, H. Li, G. Kuang, J. Wan, and H. Li. 2019. Taxifolin inhibits breast cancer cells proliferation, migration and invasion by promoting mesenchymal to epithelial transition via β-catenin signaling. Life Sciences 232:116617. doi: 10.1016/j.lfs.2019.116617.
  • Li, Q., X. Kang, C. Shi, Y. Li, K. Majumder, Z. Ning, and J. Ren. 2018. Moderation of hyperuricemia in rats via consuming walnut protein hydrolysate diet and identification of new antihyperuricemic peptides. Food & Function 9 (1):107–16. doi: 10.1039/C7FO01174A.
  • Li, X., T. Ohtsuki, T. Koyano, T. Kowithayakorn, and M. Ishibashi. 2009. New Wnt/beta-catenin signaling inhibitors isolated from Eleutherine palmifolia . Chemistry, an Asian Journal 4 (4):540–7. doi: 10.1002/asia.200800354.
  • Li, Y., Z. Wang, D. Kong, S. Murthy, Q. P. Dou, S. Sheng, G. P. V. Reddy, and F. H. Sarkar. 2007. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells . The Journal of Biological Chemistry 282 (29):21542–50. doi: 10.1074/jbc.M701978200.
  • Li, Y., and T. Zhang. 2013. Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts. Future Oncology (London, England) 9 (8):1097–103. doi: 10.2217/fon.13.108.
  • Liang, J. J., H. R. Li, Y. Chen, C. Zhang, D. G. Chen, Z. C. Liang, Y. Q. Shi, L. L. Zhang, L. Xin, and D. B. Zhao. 2019. Diallyl trisulfide can induce fibroblast-like synovial apoptosis and has a therapeutic effect on collagen-induced arthritis in mice via blocking NF-κB and Wnt pathways. International Immunopharmacology 71:132–8. doi: 10.1016/j.intimp.2019.03.024.
  • Liao, W., R. Zhang, C. Dong, Z. Yu, and J. Ren. 2016. Novel walnut peptide-selenium hybrids with enhanced anticancer synergism: Facile synthesis and mechanistic investigation of anticancer activity. International Journal of Nanomedicine 11:1305–21. doi: 10.2147/IJN.S92257.
  • Lim, X., and R. Nusse. 2013. Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harbor Perspectives in Biology 5 (2):a008029. doi: 10.1101/cshperspect.a008029.
  • Lin, L.-C., C.-T. Yeh, C.-C. Kuo, C.-M. Lee, G.-C. Yen, L.-S. Wang, C.-H. Wu, W.-C V. Yang, and A. T. Wu. 2012. Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function. Journal of Agricultural and Food Chemistry 60 (28):7031–9. doi: 10.1021/jf301981n.
  • Lin, M.-C., F.-Y. Wang, Y.-H. Kuo, and F.-Y. Tang. 2011. Cancer chemopreventive effects of lycopene: Suppression of MMP-7 expression and cell invasion in human colon cancer cells. Journal of Agricultural and Food Chemistry 59 (20):11304–18. doi: 10.1021/jf202433f.
  • Lin, X., L. Yang, M. Wang, T. Zhang, M. Liang, E. Yuan, and J. Ren. 2018. Preparation, purification and identification of cadmium-induced osteoporosis-protective peptides from chicken sternal cartilage. Journal of Functional Foods 51:130–41. doi: 10.1016/j.jff.2018.09.036.
  • Lin, Y.-C., L. You, Z. Xu, B. He, I. Mikami, E. Thung, J. Chou, K. Kuchenbecker, J. Kim, D. Raz, et al. 2006. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochemical and Biophysical Research Communications 341 (2):635–40. doi: 10.1016/j.bbrc.2005.12.220.
  • Lin, Z., W. Liao, and J. Ren. 2016. Physicochemical characterization of a polysaccharide fraction from Platycladus orientalis (L.) franco and its macrophage immunomodulatory and anti-hepatitis B virus activities. Journal of Agricultural and Food Chemistry 64 (29):5813–23. doi: 10.1021/acs.jafc.6b01387.
  • Liu, F., S. Zhang, M. Yin, L. Guo, M. Xu, and Y. Wang. 2019. Nobiletin inhibits hypoxia‐induced epithelial–mesenchymal transition in renal cell carcinoma cells. Journal of Cellular Biochemistry 120 (2):2039–46. doi: 10.1002/jcb.27511.
  • Liu, J., F. Ke, H. Cheng, and J. Zhou. 2019. Traditional Chinese medicine as targeted treatment for epithelial–mesenchymal transition‐induced cancer progression. Journal of Cellular Biochemistry 120 (2):1068–79. doi: 10.1002/jcb.27588.
  • Liu, J., H. Zhu, B. Li, S. C. Robinson, C. Lee, J. S. O'Connell, E. Bindi, S. Zheng, P. M. Sherman, and A. Pierro. 2020. Lactoferrin reduces necrotizing enterocolitis severity by upregulating intestinal epithelial proliferation. European Journal of Pediatric Surgery 30 (01):090–5. doi: 10.1055/s-0039-1693728.
  • Liu, M., S. A. Wilk, A. Wang, L. Zhou, R.-H. Wang, W. Ogawa, C. Deng, L. Q. Dong, and F. Liu. 2010. Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. The Journal of Biological Chemistry 285 (47):36387–94. doi: 10.1074/jbc.M110.169284.
  • Liu, W., D.-D. Yi, J.-L. Guo, Z.-X. Xiang, L.-F. Deng, and L. He. 2015. Nuciferine, extracted from Nelumbo nucifera Gaertn, inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer. Journal of Ethnopharmacology 165:83–93. doi: 10.1016/j.jep.2015.02.015.
  • Liu, Y., Z. Sun, D. Xu, J. Liu, X. Li, X. Wu, Y. Zhang, Q. Wang, C. Huang, X. Meng, et al. 2017. Hesperidin derivative-11 inhibits fibroblast-like synoviocytes proliferation by activating secreted frizzled-related protein 2 in adjuvant arthritis rats. European Journal of Pharmacology 794 (5):173–83. doi: 10.1016/j.ejphar.2016.10.004.
  • Logan, C. Y., and R. Nusse. 2004. The Wnt signaling pathway in development and disease. Annual Review of Cell and Developmental Biology 20 (1):781–810. doi: 10.1146/annurev.cellbio.20.010403.113126.]
  • Macdonald, B. T., K. Tamai, and X. He. 2009. Wnt/beta-catenin signaling: Components, mechanisms, and diseases . Developmental Cell 17 (1):9–26. doi: 10.1016/j.devcel.2009.06.016.
  • Maelandsmo, G. M., R. Holm, J. M. Nesland, Ø. Fodstad, and V. A. Flørenes. 2003. Reduced β-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma. Clinical Cancer Research 9 (9):3383–8. doi: 10.1002/cncr.11601.
  • Mao, X., Y. Jin, T. Feng, H. Wang, D. Liu, Z. Zhou, Q. Yan, H. Yang, J. Yang, J. Yang, et al. 2020. Ginsenoside Rg3 inhibits the growth of osteosarcoma and attenuates metastasis through the Wnt/β-catenin and EMT signaling pathway. Evidence-Based Complementary and Alternative Medicine: eCAM 2020 (1):6065124–12. doi: 10.1155/2020/6065124.
  • Marcucci, F., G. Stassi, and R. De Maria. 2016. Epithelial–mesenchymal transition: A new target in anticancer drug discovery. Nature Reviews. Drug Discovery 15 (5):311–25. doi: 10.1038/nrd.2015.13.
  • Markowitz, S. D., and M. M. Bertagnolli. 2009. Molecular origins of cancer: Molecular basis of colorectal cancer. The New England Journal of Medicine 361 (25):2449–60. doi: 10.1056/NEJMra0804588.
  • Mogoşanu, G. D., and A. M. Grumezescu. 2014. Natural and synthetic polymers for wounds and burns dressing. International Journal of Pharmaceutics 463 (2):127–36. doi: 10.1016/j.ijpharm.2013.12.015.
  • Molagoda, I. M. N., W. A. H. M. Karunarathne, Y. H. Choi, E. K. Park, Y.-J. Jeon, B.-J. Lee, C.-H. Kang, and G.-Y. Kim. 2019. Fermented oyster extract promotes osteoblast differentiation by activating the Wnt/β-catenin signaling pathway, leading to bone formation. Biomolecules 9 (11):711. doi: 10.3390/biom9110711.
  • Murakami, A., H. Ashida, and J. Terao. 2008. Multitargeted cancer prevention by quercetin. Cancer Letters 269 (2):315–25. doi: 10.1016/j.canlet.2008.03.046.
  • Murillo, G., X. Peng, K. E. Torres, and R. G. Mehta. 2009. Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway. Cancer Prevention Research (Philadelphia, PA) 2 (11):942–50. doi: 10.1158/1538-7445.AM2012-573.
  • Narwal, M., J. Koivunen, T. Haikarainen, E. Obaji, O. E. Legala, H. Venkannagari, P. Joensuu, T. Pihlajaniemi, and L. Lehtiö. 2013. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. Journal of Medicinal Chemistry 56 (20):7880–9. doi: 10.1021/jm401463y.
  • Nittaya, B., N. Thongon, A. Chairoungdua, K. Suksen, W. Pompimon, P. Tuchinda, V. Reutrakul, and P. Piyachaturawat. 2016. 5-Acetyl goniothalamin suppresses proliferation of breast cancer cells via Wnt/β-catenin signaling. European Journal of Pharmacology 791:455–64. doi: 10.1016/j.ejphar.2016.09.024.
  • Nusse, R., and H. Clevers. 2017. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell 169 (6):985–99. doi: 10.1016/j.cell.2017.05.016.
  • Oh, Y., C. B. Ahn, and J. Y. Je. 2020. Ark shell protein‐derived bioactive peptides promote osteoblastic differentiation through upregulation of the canonical Wnt/β‐catenin signaling in human bone marrow‐derived mesenchymal stem cells. Journal of Food Biochemistry 44 (10):e13440. doi: 10.1111/jfbc.13440.
  • Otero, K., M. Shinohara, H. Zhao, M. Cella, S. Gilfillan, A. Colucci, R. Faccio, F. P. Ross, S. L. Teitelbaum, H. Takayanagi, et al. 2012. TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. Journal of Immunology (Baltimore, MD: 1950) 188 (6):2612–21. doi: 10.4049/jimmunol.1102836.
  • Oz, B., A. Yildirim, S. Yolbas, Z. B. Celik, E. O. Etem, G. Deniz, M. Akin, Z. A. Akar, A. Karatas, and S. S. Koca. 2019. Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model. BioFactors (Oxford, England) 45 (1):69–74. doi: 10.1002/biof.1463.
  • Pahlke, G., Y. Ngiewih, M. Kern, S. Jakobs, D. Marko, and G. Eisenbrand. 2006. Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. Journal of Agricultural and Food Chemistry 54 (19):7075–82. doi: 10.1021/jf0612530.
  • Pan, H., E. Kim, G. O. Rankin, Y. Rojanasakul, Y. Tu, and Y. C. Chen. 2018. Theaflavin-3,3′-digallate inhibits ovarian cancer stem cells via suppressing Wnt/β-Catenin signaling pathway . Journal of Functional Foods 50:1–7. doi: 10.1016/j.jff.2018.09.021.
  • Pandurangan, A. K., P. Dharmalingam, S. K. A. Sadagopan, M. Ramar, A. Munusamy, and S. Ganapasam. 2013. Luteolin induces growth arrest in colon cancer cells through involvement of Wnt/β-catenin/GSK-3β signaling. Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 32 (2):131–9. doi: 10.1615/JEnvironPatholToxicolOncol.2013007522.
  • Park, C. H., J. Y. Chang, E. R. Hahm, S. Park, H.-K. Kim, and C. H. Yang. 2005. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells . Biochemical and Biophysical Research Communications 328 (1):227–34. doi: 10.1016/j.bbrc.2004.12.151.
  • Park, J. E., Y. J. Hyun, M. J. Piao, K. A. Kang, Y. S. Ryu, K. Shilnikova, A. X. Zhen, M. J. Ahn, Y. S. Ahn, Y. S. Koh, et al. 2018. Mackerel-derived fermented fish oil protects skin against UVB-induced cellular damage by inhibiting oxidative stress. Journal of Functional Foods 46:147–58. doi: 10.1016/j.jff.2018.04.057.
  • Park, K.-R., J. Y. Lee, B.-M. Kim, S. W. Kang, and H.-M. Yun. 2020. TMARg, a novel anthraquinone isolated from Rubia cordifolia Nakai, increases osteogenesis and mineralization through BMP2 and β-catenin signaling. International Journal of Molecular Sciences 21 (15):5332–46. doi: 10.3390/ijms21155332.
  • Park, P.-J., B.-S. Moon, S.-H. Lee, S.-N. Kim, A.-R. Kim, H.-J. Kim, W.-S. Park, K.-Y. Choi, E.-G. Cho, and T. R. Lee. 2012. Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling. Life Sciences 91 (19–20):935–43. doi: 10.1016/j.lfs.2012.09.008.
  • Park, S., and J. Choi. 2010. Inhibition of beta-catenin/Tcf signaling by flavonoids . Journal of Cellular Biochemistry 110 (6):1376–85. doi: 10.1002/jcb.22654.
  • Paul, W., and C. P. Sharma. 2004. Chitosan and alginate wound dressings: A short review. Trends in Biomaterials and Artificial Organs 18 (1):18–23.
  • Pike, J. W., M. B. Meyer, M. Watanuki, S. Kim, L. A. Zella, J. A. Fretz, M. Yamazaki, and N. K. Shevde. 2007. Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor . The Journal of Steroid Biochemistry and Molecular Biology 103 (3–5):389–95. doi: 10.1016/j.jsbmb.2006.12.050.
  • Prangsaengtong, O., P. Jantaree, K. Lirdprapamongkol, J. Svasti, and K. Koizumi. 2018. Shikonin suppresses lymphangiogenesis via NF-κB/HIF-1α axis inhibition. Biological & Pharmaceutical Bulletin 41 (11):1659–66. doi: 10.1248/bpb.b18-00329.
  • Pujia, A., C. Russo, S. Maurotti, R. Pujia, V. Mollace, S. Romeo, and T. Montalcini. 2018. Bergamot polyphenol fraction exerts effects on bone biology by activating ERK 1/2 and Wnt/β-catenin pathway and regulating bone biomarkers in bone cell cultures. Nutrients 10 (9):1305. doi: 10.3390/nu10091305.
  • Qiu, Z.-C., Y. Zhang, H.-H. Xiao, C. Chui-Wa Poon, X.-L. Li, J.-F. Cui, M.-K. Wong, X.-S. Yao, and M.-S. Wong. 2020. 8-Prenylgenistein exerts osteogenic effects via ER α and Wnt-dependent signaling pathway. Experimental Cell Research 395 (1):112186. doi: 10.1016/j.yexcr.2020.112186.
  • Rahman, N., M. Jeon, and Y. S. Kim. 2016. Delphinidin, a major anthocyanin, inhibits 3T3-L1 pre-adipocyte differentiation through activation of Wnt/β-catenin signaling . BioFactors (Oxford, England) 42 (1):49–59. doi: 10.1002/biof.1251.
  • Reddivari, L., V. Charepalli, S. Radhakrishnan, R. Vadde, R. J. Elias, J. D. Lambert, and J. K. Vanamala. 2016. Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis. BMC Complementary and Alternative Medicine 16 (1):278–90. doi: 10.1186/s12906-016-1254-2.
  • Ren, Z., L. Wang, J. Cui, Z. Huoc, J. Xue, H. Cui, Q. Mao, and R. Yang. 2013. Resveratrol inhibits NF-κB signaling through suppression of p65 and IB kinase activities. Die Pharmazie-An International Journal of Pharmaceutical Sciences 68 (8):689–94. doi: 10.1691/ph.2013.2916.
  • Rodrigues, T., D. Reker, P. Schneider, and G. Schneider. 2016. Counting on natural products for drug design. Nature Chemistry 8 (6):531–41. doi: 10.1038/nchem.2479.
  • Rosen, E. D., and O. A. MacDougald. 2006. Adipocyte differentiation from the inside out. Nature Reviews. Molecular Cell Biology 7 (12):885–96. doi: 10.1038/nrm2066.
  • Russo, G. L., and P. Ungaro. 2019. Epigenetic Mechanisms of Quercetin and Other Flavonoids in Cancer Therapy and Prevention Epigenetics of Cancer Prevention. (Vol. 8, 187–202. Elsevier.
  • Saleem, M. 2009. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Letters 285 (2):109–15. doi: 10.1016/j.canlet.2009.04.033.
  • Sarkar, F. H., Y. Li, Z. Wang, and D. Kong. 2010. The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Reviews 29 (3):383–94. doi: 10.1007/s10555-010-9233-4.
  • Saunders, I. T., H. Mir, N. Kapur, and S. Singh. 2017. Emodin exerts its anticancer effect on colon cancer cells by inhibiting proliferation and inducing apoptosis: AACR.
  • Schulze, M. B., and K. Hoffmann. 2006. Methodological approaches to study dietary patterns in relation to risk of coronary heart disease and stroke. The British Journal of Nutrition 95 (5):860–9. doi: 10.1079/BJN20061731.
  • Schulze, M. B., M. A. Martínez-González, T. T. Fung, A. H. Lichtenstein, and N. G. Forouhi. 2018. Food based dietary patterns and chronic disease prevention. BMJ (Clinical Research ed.) 361:k2396. doi: 10.1136/bmj.k2396.
  • Schwab, R. H., N. Amin, D. J. Flanagan, T. M. Johanson, T. J. Phesse, and E. Vincan. 2018. Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells. Developmental Dynamics: An Official Publication of the American Association of Anatomists 247 (3):521–30. doi: 10.1002/dvdy.24527.
  • Senthilkumar, K., J. Venkatesan, and S.-K. Kim. 2014. Marine derived natural products for osteoporosis. Biomedicine & Preventive Nutrition 4 (1):1–7. doi: 10.1016/j.bionut.2013.12.005.
  • Seo, S. H., S. H. Lee, P. H. Cha, M. Y. Kim, D. S. Min, and K. Y. Choi. 2016. Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing . Phytotherapy Research: PTR 30 (5):848–54. doi: 10.1002/ptr.5593.
  • Serafino, A., G. Sferrazza, A. Colini Baldeschi, G. Nicotera, F. Andreola, E. Pittaluga, and P. Pierimarchi. 2017. Developing drugs that target the Wnt pathway: Recent approaches in cancer and neurodegenerative diseases. Expert Opinion on Drug Discovery 12 (2):169–86. doi: 10.1080/17460441.2017.1271321.
  • Shan, B.-E., M.-X. Wang, and R-q Li. 2009. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway . Cancer Investigation 27 (6):604–12. doi: 10.1080/07357900802337191.
  • Sharma, M., I. Castro-Piedras, G. E. Simmons, Jr., and K. Pruitt. 2018. Dishevelled: A masterful conductor of complex Wnt signals. Cellular Signalling 47:52–64. doi: 10.1016/j.cellsig.2018.03.004.
  • Shtutman, M., J. Zhurinsky, I. Simcha, C. Albanese, M. D'Amico, R. Pestell, and A. Ben-Ze'ev. 1999. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway . Proceedings of the National Academy of Sciences of the United States of America 96 (10):5522–7. doi: 10.1073/pnas.96.10.5522.
  • Singh, A. K., N. Sharma, M. Ghosh, Y. H. Park, and D. K. Jeong. 2017. Emerging importance of dietary phytochemicals in fight against cancer: Role in targeting cancer stem cells. Critical Reviews in Food Science and Nutrition 57 (16):3449–63. doi: 10.1080/10408398.2015.1129310.
  • Sinnberg, T., M. Menzel, D. Ewerth, B. Sauer, M. Schwarz, M. Schaller, C. Garbe, and B. Schittek. 2011. β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PloS One 6 (8):e23429. doi: 10.1371/journal.pone.0023429.
  • Slack, J. M., and D. Tosh. 2001. Transdifferentiation and metaplasia—Switching cell types. Current Opinion in Genetics & Development 11 (5):581–6. doi: 10.1016/S0959-437X(00)00236-7.
  • Song, S.-H., I.-H. Kim, and T.-J. Nam. 2012. Effect of a hot water extract of Chlorella vulgaris on proliferation of IEC-6 of IEC-6 cells. International journal of Molecular Medicine 29 (5):741–6. doi: 10.3892/ijmm.2012.899.
  • Song, X., S. Wang, and L. Li. 2014. New insights into the regulation of Axin function in canonical Wnt signaling pathway. Protein & Cell 5 (3):186–93. doi: 10.1007/s13238-014-0019-2.
  • Song, X., Y. Zhou, M. Zhou, Y. Huang, Z. Li, Q. You, N. Lu, and Q. Guo. 2015. Wogonin influences vascular permeability via Wnt/β-catenin pathway . Molecular Carcinogenesis 54 (7):501–12. doi: 10.1002/mc.22093.
  • Song, Y., G. H. Oh, M.-B. Kim, and J.-K. Hwang. 2017. Fucosterol inhibits adipogenesis through the activation of AMPK and Wnt/β-catenin signaling pathways. Food Science and Biotechnology 26 (2):489–94. doi: 10.1007/s10068-017-0067-5.
  • Soubh, A. A., D. M. Abdallah, and H. S. El-Abhar. 2015. Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways. Life Sciences 136:142–50. doi: 10.1016/j.lfs.2015.07.004.
  • Sp, N., D. Y. Kang, E. S. Jo, A. Rugamba, W. S. Kim, Y.-M. Park, D.-Y. Hwang, J.-S. Yoo, Q. Liu, K.-J. Jang, et al. 2020. Tannic acid promotes TRAIL-induced extrinsic apoptosis by regulating mitochondrial ROS in human embryonic carcinoma cells. Cells 9 (2):282. doi: 10.3390/cells9020282.
  • Srinivasan, A., C. Thangavel, Y. Liu, S. Shoyele, R. B. Den, P. Selvakumar, and A. Lakshmikuttyamma. 2016. Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer . Molecular Carcinogenesis 55 (5):743–56. doi: 10.1002/mc.22318.
  • Su, T.-R., J.-J. Lin, C.-C. Tsai, T.-K. Huang, Z.-Y. Yang, M.-O. Wu, Y.-Q. Zheng, C.-C. Su, and Y.-J. Wu. 2013. Inhibition of melanogenesis by gallic acid: Possible involvement of the PI3K/Akt, MEK/ERK and Wnt/β-catenin signaling pathways in B16F10 cells. International Journal of Molecular Sciences 14 (10):20443–58. doi: 10.3390/ijms141020443.
  • Sun, D., J. Chen, H. Hu, S. Lin, L. Jin, L. Luo, X. Yan, and C. Zhang. 2019. Acanthopanax senticosus polysaccharide suppressing proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells is associated with Wnt/β-catenin signaling. Neoplasma 66 (4):555–63. doi: 10.4149/neo_2018_180913N689.
  • Sun, Q., H. Yang, P. Tang, J. Liu, W. Wang, and H. Li. 2018. Interactions of cinnamaldehyde and its metabolite cinnamic acid with human serum albumin and interference of other food additives. Food Chemistry 243:74–81. doi: 10.1016/j.foodchem.2017.09.109.
  • Syed, D. N., F. Afaq, N. Maddodi, J. J. Johnson, S. Sarfaraz, A. Ahmad, V. Setaluri, and H. Mukhtar. 2011. Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels. The Journal of Investigative Dermatology 131 (6):1291–9. doi: 10.1038/jid.2011.6.
  • Takebe, N., P. J. Harris, R. Q. Warren, and S. P. Ivy. 2011. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nature Reviews. Clinical Oncology 8 (2):97–106. doi: 10.1038/nrclinonc.2010.196.
  • Tan, B. L., M. E. Norhaizan, K. Huynh, S. R. Heshu, S. K. Yeap, H. Hazilawati, and K. Roselina. 2015. Water extract of brewers’ rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers’ rice-treated rats with azoxymethane-induced colon carcinogenesis. BMC Complementary and Alternative Medicine 15 (1):205. doi: 10.1186/s12906-015-0730-4.
  • Tang, C., L. Gong, L. Xu, K. Qiu, and L. Wan. 2020. Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway. Biochemical and Biophysical Research Communications 526 (1):170–5. doi: 10.1016/j.bbrc.2020.03.050.
  • Tarapore, R. S., I. A. Siddiqui, M. Saleem, V. M. Adhami, V. S. Spiegelman, and H. Mukhtar. 2010. Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis 31 (10):1844–53. doi: 10.1093/carcin/bgq169.
  • Temraz, S., D. Mukherji, and A. Shamseddine. 2013. Potential targets for colorectal cancer prevention. International Journal of Molecular Sciences 14 (9):17279–303. doi: 10.3390/ijms140917279.
  • Thorne, C. A., A. J. Hanson, J. Schneider, E. Tahinci, D. Orton, C. S. Cselenyi, K. K. Jernigan, K. C. Meyers, B. I. Hang, A. G. Waterson, et al. 2010. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nature Chemical Biology 6 (11):829–36. doi: 10.1038/nchembio.453.
  • Tian, L., Z. Song, W. Shao, W. W. Du, L. R. Zhao, K. Zeng, B. B. Yang, and T. Jin. 2017. Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2. Cell Death & Disease 8 (1):e2559. doi: 10.1038/cddis.2016.455.
  • Truong, V.-L., M. J. Bak, C. Lee, M. Jun, and W.-S. Jeong. 2017. Hair regenerative mechanisms of red ginseng oil and its major components in the testosterone-induced delay of anagen entry in C57BL/6 mice. Molecules 22 (9):1505. doi: 10.3390/molecules22091505.
  • Tu, X., J. Delgado-Calle, K. W. Condon, M. Maycas, H. Zhang, N. Carlesso, M. M. Taketo, D. B. Burr, L. I. Plotkin, and T. Bellido. 2015. Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone. Proceedings of the National Academy of Sciences of the United States of America 112 (5):E478–86. doi: 10.1073/pnas.1409857112.
  • Tulchinsky, E. 2017. Colorectal cancer cells use the negative feedback regulators of WNT signalling to activate epithelial–mesenchymal transition pathways. Gut 66 (4):563–4. doi: 10.1136/gutjnl-2016-313185.
  • Uzarska, M., R. Czajkowski, R. A. Schwartz, A. Bajek, B. Zegarska, and T. Drewa. 2013. Chemoprevention of skin melanoma: Facts and myths. Melanoma Research 23 (6):426–33. doi: 10.1097/CMR.0000000000000016.
  • Vadde, R., S. Radhakrishnan, H. E. K. Kurundu, L. Reddivari, and J. K. Vanamala. 2016. Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1. Journal of Functional Foods 25:267–78. doi: 10.1016/j.jff.2016.06.007.
  • van Staalduinen, J., D. Baker, P. ten Dijke, and H. van Dam. 2018. Epithelial–mesenchymal-transition-inducing transcription factors: New targets for tackling chemoresistance in cancer? Oncogene 37 (48):6195–211. doi: 10.1038/s41388-018-0378-x.
  • Vargas, A. J., and P. A. Thompson. 2012. Diet and nutrient factors in colorectal cancer risk. Nutrition in Clinical Practice: Official Publication of the American Society for Parenteral and Enteral Nutrition 27 (5):613–23. doi: 10.1177/0884533612454885.
  • Vitaglione, P., V. Fogliano, S. Stingo, L. Scalfi, N. Caporaso, and F. Morisco. 2007. Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection. European Journal of Clinical Nutrition 61 (7):906–15. doi: 10.1038/sj.ejcn.1602571.
  • Wan, D., Y. Fu, Y. Le, P. Zhang, J. Ju, B. Wang, G. Zhang, Z. Wang, H. Su, and L. Wang. 2019. Luteolin-7-glucoside promotes human epidermal stem cell proliferation by upregulating β-catenin, c-Myc, and cyclin expression. Stem Cells International, 2019, 1–10. doi: 10.1155/2019/1575480.
  • Wan, W., S. Xia, B. Kalionis, L. Liu, and Y. Li. 2014. The role of Wnt signaling in the development of Alzheimer's disease: A potential therapeutic target? BioMed Research International 2014:301575. doi: 10.1155/2014/301575.
  • Wang, C.-Y., W. Zheng, T. Wang, J.-W. Xie, S.-L. Wang, B.-L. Zhao, W.-P. Teng, and Z.-Y. Wang. 2011. Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 36 (5):1073–89. doi: 10.1038/npp.2010.245.
  • Wang, F., Y. Zhao, Y. Liu, P. Yu, Z. Yu, J. Wang, and C. Xue. 2017. Peptides from Antarctic krill (Euphausia superba) ameliorate senile osteoporosis via activating osteogenesis related BMP2/Smads and Wnt/β‐catenin pathway. Journal of Food Biochemistry 41 (4):e12381. doi: 10.1111/jfbc.12381.
  • Wang, H., Y.Tang, Y.Fang, M.Zhang, H.Wang, Z.He,B.Wang, Q.Xu, and Y.Huang. 2019. Reprogramming tumor immune microenvironment (TIME) andWang, H.Y.Tang, Y.Fang, M.Zhang, H.Wang, Z.He, B.WangQ.XuY.Huang. 2019. Reprogramming tumor immune microenvironment (TIME) and
  • metabolism via biomimetic targeting codelivery of Shikonin/JQ1. Nano Letters19 (5):2935–44. doi: 10.1021/acs.nanolett.9b00021.
  • Wang, L., Y.-F. ChiZ.-T. Yuan, W.-C. Zhou, P.-H. Yin, X.-M.Zhang, and W. Peng. 2014. Astragaloside IV inhibits the up-regulation of Wnt/β-catenin signaling in rats with unilateral ureteral obstruction. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 33 (5):1316–28. doi: 10.1159/000358699.
  • Wang, M., A. W.Kwame, L.GuoC.Gong, Y.Zhao, M.Yao, and J.Ren. 2019. WalnutMderived peptide PW5 ameliorates cognitive impairments and alters gut microbiota in APP/PS1 transgenic mice. Molecular Nutrition & Food Research63 (18):1900326. doi: 10.1002/mnfr.201900326
  • Wang, Q., Y. Lin, X. Sheng, J. Xu, X. Hou, Y. Li, H. Zhang, H. Guo, Z. Yu, and F. Ren. 2020. Arachidonic acid promotes intestinal regeneration by activating WNT signaling. Stem Cell Reports 15 (2):374–88. doi: 10.1016/j.stemcr.2020.06.009.
  • Wang, Y.-Q., N.-X. Wang, Y. Luo, C.-Y. Yu, and J.-H. Xiao. 2020. Ganoderal A effectively induces osteogenic differentiation of human amniotic mesenchymal stem cells via cross-talk between Wnt/β-catenin and BMP/SMAD signaling pathways. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 123:109807. doi: 10.1016/j.biopha.2019.109807.
  • Wang, Y., Y.-P. Li, C. Paulson, J.-Z. Shao, X. Zhang, M.Wu, and W. Chen. 2014. Wnt and the Wnt signaling pathway in bone development and disease. Frontiers in Bioscience (Landmark Edition) 19 (3):379–407. doi:10.2741/4214.
  • Wee, L. H., N. A. Morad, G. J. Aan, S. Makpol, W. Z. W. Ngah, and Y. A. M. Yusof. 2015. Mechanism of chemoprevention against colon cancer cells using combined Gelam honey and Ginger extract via mTOR and Wnt/β-catenin pathways. Asian Pacific Journal of Cancer Prevention: APJCP 16 (15):6549–56. doi: 10.7314/APJCP.2015.16.15.6549.
  • Wertz, K. 2009. Lycopene effects contributing to prostate health. Nutrition and Cancer 61 (6):775–83. doi: 10.1080/01635580903285023.
  • Wu, C.-H., B.-H. Hong, C.-T. Ho, and G.-C. Yen. 2015. Targeting cancer stem cells in breast cancer: Potential anticancer properties of 6-shogaol and pterostilbene. Journal of Agricultural and Food Chemistry 63 (9):2432–41. doi: 10.1021/acs.jafc.5b00002.
  • Wu, C., Y. Zhuang, S. Jiang, F. Tian, Y. Teng, X. Chen, P. Zheng, S. Liu, J. Zhou, J. Wu, et al. 2017. Cinnamaldehyde induces apoptosis and reverses epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in non-small cell lung cancer. The International Journal of Biochemistry & Cell Biology 84:58–74. doi: 10.1016/j.biocel.2017.01.005.
  • Wu, D., and W. Pan. 2010. GSK3: A multifaceted kinase in Wnt signaling. Trends in Biochemical Sciences 35 (3):161–8. doi: 10.1016/j.tibs.2009.10.002.
  • Xie, D., X. Li, X. Qi, Y. Wan, Y. Zhu, and S. Yang. 2019. Berberine inhibits cell growth via Wnt/beta-catenin signaling in glioma. International Journal of Clinical and Experimental Medicine 12 (1):652–7.
  • Xu, J., J. R. Prosperi, N. Choudhury, O. I. Olopade, and K. H. Goss. 2015. β-Catenin is required for the tumorigenic behavior of triple-negative breast cancer cells. PloS One 10 (2):e0117097. doi: 10.1371/journal.pone.0117097.
  • Xu, M., S. Wang, Y. Song, J. Yao, K. Huang, and X. Zhu. 2016. Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway. Oncology Letters 11 (5):3075–80. doi: 10.3892/ol.2016.4331.
  • Yan, K. S., C. Y. Janda, J. Chang, G. X. Y. Zheng, K. A. Larkin, V. C. Luca, L. A. Chia, A. T. Mah, A. Han, J. M. Terry, et al. 2017. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal . Nature 545 (7653):238–42. doi: 10.1038/nature22313.
  • Yan, L., J. Chen, X. Zhu, J. Sun, X. Wu, W. Shen, W. Zhang, Q. Tao, and A. Meng. 2018. Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science 362 (6417):eaat1045. doi: 10.1126/science.aat1045.
  • Yang, H.-L., Y.-C. Tsai, M. Korivi, C.-T. Chang, and Y.-C. Hseu. 2017. Lucidone promotes the cutaneous wound healing process via activation of the PI3K/AKT, Wnt/β-catenin and NF-κB signaling pathways. Biochimica et Biophysica Acta. Molecular Cell Research 1864 (1):151–68. doi: 10.1016/j.bbamcr.2016.10.021.
  • Yang, H., T. Tian, D. Wu, D. Guo, and J. Lu. 2018. Prevention and treatment effects of edible berries for three deadly diseases: Cardiovascular disease, cancer and diabetes. Critical Reviews in Food Science & Nutrition 59:1903–12. doi: 10.1080/10408398.2018.1432562.
  • Yang, J., W. Zhang, P. M. Evans, X. Chen, X. He, and C. Liu. 2006. Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells . The Journal of Biological Chemistry 281 (26):17751–57. doi: 10.1074/jbc.M600831200.
  • Yang, P., W. Liu, R. Fu, G-b Ding, S. Amin, and Z. Li. 2020. Cucurbitacin E chemosensitizes colorectal cancer cells via mitigating TFAP4/Wnt/β-catenin signaling. Journal of Agricultural and Food Chemistry 68 (48):14148–14160. doi: 10.1021/acs.jafc.0c05551.
  • Ye, M., C. Zhang, L. Zhu, W. Jia, and Q. Shen. 2020. Yak (Bos grunniens) bones collagen-derived peptides stimulate osteoblastic proliferation and differentiation via the activation of Wnt/β-catenin signaling pathway . Journal of the Science of Food and Agriculture 100 (6):2600–09. doi: 10.1002/jsfa.10286.
  • Yodthong, T., U. Kedjarune-Leggat, C. Smythe, P. Sukprasirt, A. Aroonkesorn, R. Wititsuwannakul, and T. Pitakpornpreecha. 2020. Enhancing ACTIVITY of Pleurotus sajor-caju (Fr.) sing β-1, 3-glucanoligosaccharide (Ps-GOS) on proliferation, differentiation, and mineralization of MC3T3-E1 cells through the involvement of BMP-2/Runx2/MAPK/Wnt/β-catenin signaling pathway. Biomolecules 10 (2):190. doi: 10.3390/biom10020190.
  • Zachary, S., and A. Stephane. 2018. Wnt signaling in development and tissue homeostasis. Development 145 (11): dev146589. doi: 10.1242/dev.146589.
  • Zeng, Q., Y. Che, Y. Zhang, M. Chen, Q. Guo, and W. Zhang. 2020. Thymol Isolated from Thymus vulgaris L. inhibits colorectal cancer cell growth and metastasis by suppressing the Wnt/β-catenin pathway. Drug Design, Development and Therapy 14:2535–47. doi: 10.2147/DDDT.S254218.
  • Zhan, T., N. Rindtorff, and M. Boutros. 2017. Wnt signaling in cancer. Oncogene 36 (11):1461–1473. doi: 10.1038/onc.2016.304.
  • Zhang, J.-S., S.-J. Zhang, Q. Li, Y.-H. Liu, N. He, J. Zhang, P.-H. Zhou, M. Li, T. Guan, and J.-R. Liu. 2015. Tocotrienol-rich fraction (TRF) suppresses the growth of human colon cancer xenografts in Balb/C nude mice by the Wnt pathway. PloS One 10 (3):e0122175. doi: 10.1371/journal.pone.0122175.
  • Zhang, Y., and H. Chen. 2011. Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line. Experimental Biology and Medicine (Maywood, N.J.) 236 (6):714–22. doi: 10.1258/ebm.2011.010347.
  • Zhang, Y., L. J. Huang,S Shi, S. F.L. Wang, and Y.Peng. 2016. L-3-n-butylphthalide rescues hippocampal synaptic failure and attenuates neuropathology in aged APP/PS1 mouse model of Alzheimer's disease . CNS Neuroscience & Therapeutics 22 (12):979–87. doi: 10.1111/cns.12594
  • Zhang, Y., and X. Wang. 2020. Targeting the Wnt/β-catenin signaling pathway in cancer. Journal of Hematology & Oncology 13 (1):1–16. doi: 10.1186/s13045-020-00990-3.
  • Zhang, ., H. Chen, C. Xu, L. Song, L. Huang, Y. Lai, Y. Wang, H. Chen, D. GuL.Ren, et al.2016. Curcumin inhibits tumor epithelial-mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells. Oncology Reports 35 (5):2615–23. doi:10.3892/or.2016.4669
  • Zhang, Z., H. Chen, C. Xu, L. Song, L. Huang, Y. Lai, Y. Wang, H. Chen, D. Gu, L. Ren, et al. 2016. Curcumin inhibits tumor epithelial-mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells. Oncology Reports 35 (5):2615–23. doi: 10.3892/or.2016.4669.
  • Zhen-Nan, Ye, F. Yuan, J.-Q. Liu, X.-R. Peng, T. An, X. Li, L.-M. Kong, M.-H. Qiu, and Y. Li. 2019. Physalis peruviana-derived 4β-hydroxywithanolide E, a novel antagonist of Wnt signaling, inhibits colorectal cancer in vitro and in vivo. Molecules 24 (6):1146. doi: 10.3390/molecules24061146.
  • Zhou, J.-Y., H.-L. Lin, Z. Wang, S.-W. Zhang, D.-G. Huang, C.-Q. Gao, H.-C. Yan, and X.-Q. Wang. 2020. Zinc L-aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway. Environmental Pollution 262:114290. doi: 10.1016/j.envpol.2020.114290.
  • Zhou, J.-Y., S.-W. Zhang, H.-L. Lin, C.-Q. Gao, H.-C. Yan, and X.-Q. Wang. 2019. Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 131:110579. doi: 10.1016/j.fct.2019.110579.
  • Zhu, J., S. Wang, Y. Chen, X. Li, Y. Jiang, X. Yang, Y. Li, X. Wang, Y. Meng, M. Zhu, et al. 2017. miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells. The Journal of Nutritional Biochemistry 44:80–91. doi: 10.1016/j.jnutbio.2017.02.020.
  • Zhu, M., X. Yu, Z. Zheng, J. Huang, X. Yang, and H. Shi 2020. Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway . Phytotherapy Research: PTR 34 (4):817–24. doi: 10.1002/ptr.6563.
  • Zhu, P.-Y., W.-H. Yin, M.-R. Wang, Y.-Y. Dang, and X.-Y. Ye. 2015. Andrographolide suppresses melanin synthesis through Akt/GSK3β/β-catenin signal pathway. Journal of Dermatological Science 79 (1):74–83. doi: 10.1016/j.jdermsci.2015.03.013.
  • Zhu, X., X. Tian, M. Yang, Y. Yu, Y. Zhou, Y. Gao, L. Zhang, Z. Li, Y. Xiao, and R. E. Moses. 2020. Procyanidin B2 promotes intestinal injury repair and attenuates colitis-associated tumorigenesis via suppression of oxidative stress in mice. Antioxidants & Redox Signaling. doi: 10.1089/ars.2019.7911.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.