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In vitro evidence of the antitumor capacity of Solanaceae and Cucurbitaceae in colon cancer: A systematic review

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References

  • Abdel-Sattar, E., M. Farag, and E. Mahrous. 2013. Chemical Constituents from solanum glabratum dunal var. Sepicula. Planta Medica 79 (13):94–104. doi: 10.1055/s-0033-1352092.
  • Abdelwahab, S. I., L. E. A. Hassan, A. M. S. Abdul Majid, S. M. A. Yagi, S. Mohan, M. M. Elhassan Taha, S. Ahmad, C. S. Chuen, P. Narrima, M. M. Rais, et al. 2012. Cucurbitacin L 2-O- β -glucoside demonstrates apoptogenesis in colon adenocarcinoma cells (ht-29): involvement of reactive oxygen and nitrogen species regulation. Evidence-Based Complementary and Alternative Medicine 2012:1–8. doi: 10.1155/2012/490136.
  • Alali, F. Q., C. S. M. Amrine, T. El-Elimat, A. Alkofahi, K. Tawaha, M. Gharaibah, S. M. Swanson, J. O. Falkinham, M. Cabeza, A. Sánchez, et al. 2014. Bioactive withanolides from withania obtusifolia. Phytochemistry Letters 9 (1):96–101. doi: 10.1016/j.phytol.2014.05.002.
  • Alghasham, A. A. 2013. Cucurbitacins - a promising target for cancer therapy. International Journal of Health Sciences 7 (1):77–89. doi: 10.12816/0006025.
  • Bácskay, I., D. Nemes, F. Fenyvesi, J. Váradi, G. Vasvári, P. Fehér, M. Vecsernyés, and Z. Ujhelyi. 2018. Role of cytotoxicity experiments in pharmaceutical development. In Cytotoxicity, eds Tülay Aşkin Çelik. IntechOpen doi: 10.5772/intechopen.72539.
  • Berrino, F., R. De Angelis, M. Sant, S. Rosso, M. B. Lasota, J. W. Coebergh, and M. Santaquilani. 2007. Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995–99: results of the EUROCARE-4 study. The Lancet Oncology 8 (9):773–83. doi: 10.1016/S1470-2045(07)70245-0.
  • Bhutani, K. K., A. T. Paul, W. Fayad, and S. Linder. 2010. Apoptosis inducing activity of steroidal constituents from solanum xanthocarpum and asparagus racemosus. Phytomedicine : international Journal of Phytotherapy and Phytopharmacology 17 (10):789–93. doi: 10.1016/j.phymed.2010.01.017.
  • Bortolotti, M., D. Mercatelli, and L. Polito. 2019. Momordica charantia, a nutraceutical approach for inflammatory related diseases. Frontiers in Pharmacology 10:486 doi: 10.3389/fphar.2019.00486.
  • Bray, F., J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre, and A. Jemal. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for Clinicians 68 (6):394–424. doi: 10.3322/caac.21492.
  • Bregni, G., T. Akin Telli, S. Camera, A. Deleporte, L. Moretti, A. M. Bali, G. Liberale, S. Holbrechts, A. Hendlisz, and F. Sclafani. 2020. Adjuvant Chemotherapy for rectal cancer: current evidence and recommendations for clinical practice. Cancer Treatment Reviews 83:101948 doi: 10.1016/j.ctrv.2019.101948.
  • Chan, K. T., K. Li, S. L. Liu, K. H. Chu, M. Toh, and W. D. Xie. 2010. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett 289 (1):46–52. doi: 10.1016/j.canlet.2009.07.015.
  • Chan, K. T., F. Y. Meng, Q. Li, C. Y. Ho, T. S. Lam, Y. To, W. H. Lee, M. Li, K. H. Chu, and M. Toh. 2010. Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration. Cancer Letters 294 (1):118–24. doi: 10.1016/j.canlet.2010.01.029.
  • Chawech, R., R. Jarraya, C. Girardi, M. Vansteelandt, G. Marti, I. Nasri, C. Racaud-Sultan, and N. Fabre. 2015. Cucurbitacins from the leaves of Citrullus Colocynthis (L.) schrad. Molecules (Basel, Switzerland) 20 (10):18001–15. doi: 10.3390/molecules201018001.
  • Chen, C.,. D. Zhu, H. Zhang, C. Han, G. Xue, T. Zhu, J. Luo, and L. Kong. 2018. YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of wnt signalling induced by physalin F in colorectal cancer. Cell Death & Disease 9 (6):591 doi: 10.1038/s41419-018-0645-3.
  • Cohen, J. 1968. Weighted Kappa: Nominal Scale Agreement with provision for scaled disagreement or partial credit. Psychol Bull 70 (4):213–20. doi: 10.1037/h0026256.
  • Colvin, D. M. 2018. A review on comparison of the extraction methods used in licorice root: their principle, strength and limitation. Medicinal & Aromatic Plants 07 (06):1–4. doi: 10.4172/2167-0412.1000323.
  • Cordero, C. P., S. J. Morantes, A. Páez, J. Rincón, and F. A. Aristizábal. 2009. Cytotoxicity of withanolides isolated from acnistus arborescens. Fitoterapia 80 (6):364–8. doi: 10.1016/j.fitote.2009.05.011.
  • Dandawate, P. R., D. Subramaniam, S. B. Padhye, and S. Anant. 2016. Bitter melon: a panacea for inflammation and cancer. Chinese Journal of Natural Medicines 14 (2):81–100. doi: 10.1016/S1875-5364(16)60002-X.
  • Dia, V. P., and H. B. Krishnan. 2016. BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells. Scientific Reports 6 (1):33532 doi: 10.1038/srep33532.
  • Donovan, M. G., O. I. Selmin, T. C. Doetschman, and D. F. Romagnolo. 2017. Mediterranean diet: prevention of colorectal cancer. Frontiers in nutrition 4:59 doi: 10.3389/fnut.2017.00059.
  • El Bouzidi, L., V. Mahiou-Leddet, S.-S. Bun, M. Larhsini, A. Abbad, M. Markouk, M. Fathi, M. Boudon, E. Ollivier, and K. Bekkouche. 2013. Cytotoxic withanolides from the leaves of moroccan withania frutescens. Pharm Biol 51 (8):1040–6. doi: 10.3109/13880209.2013.775162.
  • Friedman, M., C. E. Levin, S. U. Lee, H. J. Kim, I. S. Lee, J. O. Byun, and N. Kozukue. 2009. Tomatine-Containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells. J Agric Food Chem 57 (13):5727–33. doi: 10.1021/jf900364j.
  • Gordon, J., M. Brown, and M. Reynolds. 2018. Cell-based methods for determination of efficacy for candidate therapeutics in the clinical management of cancer. Diseases 6 (4):85. doi: 10.3390/diseases6040085.
  • Goyal, S., N. Gupta, S. Chatterjee, and S. Nimesh. 2017. Natural plant extracts as potential therapeutic agents for the treatment of cancer. Current Topics in Medicinal Chemistry 17 (2):96–106. doi: 10.2174/1568026616666160530154407.
  • Guil-Guerrero, J. L., R. Ramos-Bueno, I. Rodríguez-García, and C. López-Sánchez. 2011. Cytotoxicity screening of several tomato extracts. Journal of Medicinal Food 14 (1-2):40–5. doi: 10.1089/jmf.2010.0051.
  • Gupta, P., and S. K. Srivastava. 2014. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression . Oncotarget 5 (7):1812–28. doi: 10.18632/oncotarget.1743.
  • Haritunians, T., S. Gueller, L. Zhang, R. Badr, D. Yin, H. Xing, M. C. Fung, and H. P. Koeffler. 2008. Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leukemia Research 32 (9):1366–73. doi: 10.1016/j.leukres.2008.01.019.
  • Hassan, L. E. A., M. B. K. Ahamed, A. S. A. Majid, H. M. Baharetha, N. S. Muslim, Z. D. Nassar, and A. M. A. Majid. 2014. Correlation of antiangiogenic, antioxidant and cytotoxic activities of some sudanese medicinal plants with phenolic and flavonoid contents. BMC Complementary and Alternative Medicine 14 (1):406 doi: 10.1186/1472-6882-14-406.
  • Henley, A. B., L. Yang, K.-L. Chuang, M. Sahuri-Arisoylu, L.-H. Wu, S. W. A. Bligh, and J. D. Bell. 2017. Withania somnifera root extract enhances chemotherapy through 'Priming'. Plos One 12 (1):e0170917 doi: 10.1371/journal.pone.0170917.
  • Hsu, S. C., J. H. Lu, C. L. Kuo, J. S. Yang, M. W. Lin, G. W. Chen, C. C. Su, H. F. Lu, and J. G. Chung. 2008. Crude extracts of solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (Colo 205). Anticancer Research 28 (2 A):1045–54.
  • Hussain, H.,. R. Csuk, I. R. Green, N. Ur Rehman, G. Abbas, and W. Hussain. 2018. Journey describing the cytotoxic potential of withanolides: a patent review. Recent Pat Anticancer Drug Discov 13 (4):411–21. doi: 10.2174/1574892813666180808154928.
  • Idrees, M., and M. Tejani. 2019. Current treatment strategies for elderly patients with metastatic colon cancer. Cureus 11 (5):e4713 doi: 10.7759/cureus.4713.
  • Jayakumar, K., and K. Murugan. 2015. Solanum alkaloids and their pharmaceutical roles: a review. Journal of Analytical & Pharmaceutical Research 3 (6):00075. doi: 10.15406/japlr.2016.03.00075.
  • Kaunda, J. S., and Y.-J. Zhang. 2019. The genus solanum: an ethnopharmacological, phytochemical and biological properties review. Nat Prod Bioprospect 9 (2):77–137. doi: 10.1007/s13659-019-0201-6.
  • Kim, H. J., J. H. Y. Park, and J.-K. Kim. 2014. Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer. Chemico-Biological Interactions 219 (8):1–8. doi: 10.1016/j.cbi.2014.05.005.
  • Kongtun, S., W. Jiratchariyakul, T. Kummalue, P. Tan-Ariya, S. Kunnachak, and A. W. Frahm. 2009. Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. Planta Medica 75 (8):839–42. doi: 10.1055/s-0029-1185455.
  • Kwatra, D., D. Subramaniam, P. Ramamoorthy, D. Standing, E. Moran, R. Velayutham, A. Mitra, S. Umar, and S. Anant. 2013a. Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy. Evidence-Based Complementary and Alternative Medicine : eCAM 2013:702869–14. doi: 10.1155/2013/702869.
  • Kwatra, D., A. Venugopal, D. Standing, S. Ponnurangam, A. Dhar, A. Mitra, and S. Anant. 2013b. Bitter melon extracts enhance the activity of chemotherapeutic agents through the modulation of multiple drug resistance. Journal of Pharmaceutical Sciences 102 (12):4444–54. doi: 10.1002/jps.23753.
  • Lee, S.-W., M.-H. Pan, C.-M. Chen, and Z.-T. Chen. 2008. Withangulatin I, a new cytotoxic withanolide from physalis angulata. Chemical & Pharmaceutical Bulletin 56 (2):234–6. doi: 10.1248/cpb.56.234.
  • Li, X., F. Zhu, J. Jiang, C. Sun, X. Wang, M. Shen, R. Tian, C. Shi, M. Xu, F. Peng, et al. 2015. Synergistic antitumor activity of withaferin a combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the pi3k/akt pathway in human pancreatic cancer cells. Cancer Letters 357 (1):219–30. doi: 10.1016/j.canlet.2014.11.026.
  • Loree, J. M., and S. Kopetz. 2017. Recent developments in the treatment of metastatic colorectal cancer. Therapeutic Advances in Medical Oncology 9 (8):551–64. doi: 10.1177/1758834017714997.
  • Ma, Y., W. Han, J. Li, L. Hu, and Y. Zhou. 2015. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacologica Sinica 36 (4):517–27. doi: 10.1038/aps.2014.157.
  • Madiwale, G. P., L. Reddivari, D. G. Holm, and J. Vanamala. 2011. Storage elevates phenolic content and antioxidant activity but suppresses antiproliferative and pro-apoptotic properties of colored-flesh potatoes against human colon cancer cell lines. Journal of Agricultural and Food Chemistry 59 (15):8155–66. doi: 10.1021/jf201073g.
  • Madiwale, G. P., L. Reddivari, M. Stone, D. G. Holm, and J. Vanamala. 2012. Combined effects of storage and processing on the bioactive compounds and pro-apoptotic properties of color-fleshed potatoes in human colon cancer cells. Journal of Agricultural and Food Chemistry 60 (44):11088–96. doi: 10.1021/jf303528p.
  • Medjakovic, S., S. Hobiger, K. Ardjomand-Woelkart, F. Bucar, and A. Jungbauer. 2016. Pumpkin seed extract: cell growth inhibition of hyperplastic and cancer cells, independent of steroid hormone receptors. Fitoterapia 110:150–6. doi: 10.1016/j.fitote.2016.03.010.
  • Minh, C. V., N. X. Nhiem, H. T. Yen, P. V. Kiem, B. H. Tai, H. Le Tuan Anh, T. T. T. Hien, SJu Park, N. Kim, and S. H. Kim. 2015. Chemical constituents of trichosanthes kirilowii and their cytotoxic activities. Archives of Pharmacal Research 38 (8):1443–8. doi: 10.1007/s12272-014-0490-6.
  • Mondal, S., K. Bhattacharya, A. Mallick, R. Sangwan, and C. Mandal. 2012. Bak compensated for bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during withanolide d-induced apoptosis. Edited by Boris Zhivotovsky. PLoS ONE 7 (3): e34277. doi: 10.1371/journal.pone.0034277.
  • Muka, T., M. Glisic, J. Milic, S. Verhoog, J. Bohlius, W. Bramer, R. Chowdhury, and O. H. Franco. 2020. A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. European Journal of Epidemiology 35 (1):49–60. doi: 10.1007/s10654-019-00576-5.
  • Mulabagal, V., G. V. Subbaraju, C. V. Rao, C. Sivaramakrishna, D. L. DeWitt, D. Holmes, B. Sung, B. B. Aggarwal, H.-S. Tsay, and M. G. Nair. 2009. Withanolide sulfoxide from aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation. Phytotherapy Research: PTR 23 (7):987–92. doi: 10.1002/ptr.2736.
  • Nappi, A., M. Berretta, C. Romano, S. Tafuto, A. Cassata, R. Casaretti, L. Silvestro, C. D. Divitiis, L. Alessandrini, F. Fiorica, et al. 2018. Metastatic colorectal cancer: role of target therapies and future perspectives. Current Cancer Drug Targets 18 (5):421–9. doi: 10.2174/1568009617666170209095143.
  • Ohtsuki, T., T. Miyagawa, T. Koyano, T. Kowithayakorn, and M. Ishibashi. 2010. Isolation and structure elucidation of flavonoid glycosides from solanum verbascifolium. Phytochemistry Letters 3 (2):88–92. doi: 10.1016/j.phytol.2010.02.002.
  • Ozuna, C., and M. F. León-Galván. 2017. Cucurbitaceae seed protein hydrolysates as a potential source of bioactive peptides with functional properties. BioMed Research International 2017:2121878–16. doi: 10.1155/2017/2121878.
  • Park, E.-J., M. Sang-Ngern, L. C. Chang, and J. M. Pezzuto. 2016. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β-hydroxywithanolide E isolated from physalis peruviana. Molecular Nutrition & Food Research 60 (6):1482–500. doi: 10.1002/mnfr.201500977.
  • Ramalhete, C., S. Mulhovo, H. Lage, and M.-J. Ferreira. 2018. Triterpenoids from Momordica balsamina with a collateral sensitivity effect for tackling multidrug resistance in cancer cells. Planta Medica 84 (18):1372–9. doi: 10.1055/a-0651-8141.
  • Ramos-Bueno, R. P., R. Romero-González, M. J. González-Fernández, and J. L. Guil-Guerrero. 2017. Phytochemical composition and in vitro anti-tumour activities of selected tomato varieties. Journal of the Science of Food and Agriculture 97 (2):488–96. doi: 10.1002/jsfa.7750.
  • Reglero, C., and G. Reglero. 2019. Precision nutrition and cancer relapse prevention: a systematic literature review. Nutrients 11 (11):2799. doi: 10.3390/nu11112799.
  • Ren, Y., L. Shen, D.-W. Zhang, and S.-J. Dai. 2009. Two new sesquiterpenoids from solanum lyratum with cytotoxic activities. Chemical & Pharmaceutical Bulletin 57 (4):408–10. doi: 10.1248/cpb.57.408.
  • Rezig, L., M. Chouaibi, W. Meddeb, K. Msaada, and S. Hamdi. 2019. Chemical composition and bioactive compounds of Cucurbitaceae seeds: potential sources for new trends of plant oils. Process Safety and Environmental Protection 127:73–81. doi: 10.1016/j.psep.2019.05.005.
  • Ribeiro, P. R V., R. Braz-Filho, A. J. Araújo, L. V. Costa-Lotufo, L. G. S. Souza, H. V. Nobre Junior, C. R. da Silva, J. B. de Andrade Neto, E. R. Silveira, and M. A. S. Lima. 2016. New epimeric spirostanol and furostanol-type steroidal saponins from Cestrum Laevigatum L. Journal of the Brazilian Chemical Society 27 (12):2170–80. doi: 10.5935/0103-5053.20160109.
  • Rolim, P. M., G. P. Fidelis, C. E. A. Padilha, E. S. Santos, H. A. O. Rocha, and G. R. Macedo. 2018. Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis Melo L. Var. Reticulatus) and their antiproliferative effect in cancer cells. Brazilian Journal of Medical and Biological Research 51 (4):1–14. doi: 10.1590/1414-431x20176069.
  • Rotelli, M. T., D. Bocale, M. De Fazio, P. Ancona, I. Scalera, R. Memeo, E. Travaglio, A. P. Zbar, and D. F. Altomare. 2015. IN-VITRO evidence for the protective properties of the main components of the Mediterranean diet against colorectal cancer: a systematic review. Surgical Oncology 24 (3):145–52. doi: 10.1016/j.suronc.2015.08.001.
  • Russo, M., S. Moccia, S. Bilotto, C. Spagnuolo, M. Durante, M. S. Lenucci, G. Mita, M. G. Volpe, R. P. Aquino, and G. L. Russo. 2017. A carotenoid extract from a southern Italian cultivar of pumpkin triggers nonprotective autophagy in malignant cells. Oxidative Medicine and Cellular Longevity 2017:7468538–15. doi: 10.1155/2017/7468538.
  • Saunders, C. 2009. The anti-proliferative effect of different tomato varieties on the human colon adenocarcinoma cells. Bioscience Horizons 2 (2):172–9. doi: 10.1093/biohorizons/hzp020.
  • Schwingshackl, L., C. Schwedhelm, C. Galbete, and G. Hoffmann. 2017. Adherence to Mediterranean Diet and Risk of Cancer: An Updated Systematic Review and Meta-Analysis. Nutrients 9 (10):1063 doi:10.3390/nu9101063.
  • Shang, J., W. Liu, C. Yin, H. Chu, and M. Zhang. 2019. Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-ΚB signaling. Molecular Immunology 114:571–7. doi: 10.1016/j.molimm.2019.09.008.
  • Shang, L.-H., C.-M. Li, Z.-Y. Yang, D.-H. Che, J.-Y. Cao, and Y. Yu. 2012. Luffa Echinata Roxb. Induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. Molecules (Basel, Switzerland) 17 (5):5780–94. doi: 10.3390/molecules17055780.
  • Shang, L.-H., Y. Yu, D.-H. Che, B. Pan, S. Jin, and X.-L. Zou. 2016. Luffa Echinata Roxb. induced apoptosis in human colon cancer cell (SW-480) in the caspase-dependent manner and through a mitochondrial apoptosis pathway. Pharmacognosy Magazine 12 (45):25–30. doi: 10.4103/0973-1296.176017.
  • Shukla, S., S. Khan, S. Kumar, S. Sinha, M. Farhan, H. K. Bora, R. Maurya, and S. M. Meeran. 2015. Cucurbitacin B alters the expression of tumor-related genes by epigenetic modifications in NSCLC and inhibits NNK-induced lung tumorigenesis. Cancer Prevention Research (Philadelphia, Pa.) 8 (6):552–62. doi: 10.1158/1940-6207.CAPR-14-0286.
  • Song, L., J. Chang, and Z. Li. 2016. A serine protease extracted from trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food & Function 7 (2):843–54. doi: 10.1039/C5FO00760G.
  • Száva-Kováts, E. 2002. Unfounded attribution of the ‘half-life’ index-number of literature obsolescence to burton and Kebler: a literature science study. Journal of the American Society for Information Science and Technology 53 (13):1098–105. doi: 10.1002/asi.10105.
  • Tannin-Spitz, T.,. S. Grossman, S. Dovrat, H. E. Gottlieb, and M. Bergman. 2007. Growth inhibitory activity of Cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. Biochemical Pharmacology 73 (1):56–67. doi: 10.1016/j.bcp.2006.09.012.
  • Thapliyal, A., R. K. Khar, and A. Chandra. 2018. Overview of cancer and medicinal herbs used for cancer therapy. Asian Journal of Pharmaceutics 12 (1):S1–S8. doi: 10.22377/ajp.v12i01.2033.
  • Wanden-Berghe, C., and J. Sanz-Valero. 2012. Systematic reviews in nutrition: standardized methodology. British Journal of Nutrition 107 (S2):S3–S7. doi: 10.1017/S0007114512001432.
  • Wang, Q., Q. Chen, M. He, P. Mir, J. Su, and Q. Yang. 2011. Inhibitory effect of antioxidant extracts from various potatoes on the proliferation of human colon and liver cancer cells. Nutrition and Cancer 63 (7):1044–52. doi: 10.1080/01635581.2011.597538.
  • Wang, W.,. H. Yang, Y. Li, Z. Zheng, Y. Liu, H. Wang, Y. Mu, and Q. Yao. 2018. Identification of 16,25-O-diacetyl-cucurbitane F and 25-O-acetyl-23,24-dihydrocucurbitacin F as novel anti-cancer chemicals . Royal Society Open Science 5 (8):180723 doi: 10.1098/rsos.180723.
  • Widodo, N., D. Priyandoko, N. Shah, R. Wadhwa, and S. C. Kaul. 2010. Selective killing of cancer cells by Ashwagandha leaf extract and its component withanone involves ROS signaling. PLoS ONE 5 (10):e13536–10. doi: 10.1371/journal.pone.0013536.
  • Wu, D., Z. Wang, M. Lin, Y. Shang, F. Wang, J. Zhou, F. Wang, X. Zhang, X. Luo, and W. Huang. 2019. In vitro and in vivo antitumor activity of cucurbitacin C, a Novel natural product from cucumber. Front Pharmacol 10:1287 doi: 10.3389/fphar.2019.01287.
  • Xie, Z., W. Liu, H. Huang, M. Slavin, Y. Zhao, M. Whent, J. Blackford, H. Lutterodt, H. Zhou, P. Chen, et al. 2010. Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties. J Agric Food Chem 58 (21):11243–9. doi: 10.1021/jf1026372.
  • Yang, X., Y. Zhao, Y. Yang, and Y. Ruan. 2008. Isolation and characterization of immunostimulatory polysaccharide from an herb tea, gynostemma pentaphyllum makino. Journal of Agricultural and Food Chemistry 56 (16):6905–9. doi: 10.1021/jf801101u.
  • Yao, F., Q.-L. Song, L. Zhang, G.-S. Li, and S.-J. Dai. 2013. Solajiangxins A–C. Three New Cytotoxic Sesquiterpenoids from Solanum Lyratum. Fitoterapia 89 (1):200–4. doi: 10.1016/j.fitote.2013.05.020.
  • Yin, D., N. Wakimoto, H. Xing, D. Lu, T. Huynh, X. Wang, K. L. Black, and H. P. Koeffler. 2008. Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. International Journal of Cancer 123 (6):1364–75. doi: 10.1002/ijc.23648.
  • Zhang, Q.-W., L.-G. Lin, and W.-C. Ye. 2018. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Medicine 13 (1):20 doi: 10.1186/s13020-018-0177-x.
  • Zhang, Y., D. Ouyang, L. Xu, Y. Ji, Q. Zha, J. Cai, and X. He. 2011. Cucurbitacin B induces rapid depletion of the G-Actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. Acta Biochim Biophys Sin (Shanghai) 43 (7):556–67. doi: 10.1093/abbs/gmr042.
  • Zhang, Y.-T., L.-H. Xu, Q. Lu, K.-P. Liu, P.-Y. Liu, F. Ji, X.-M. Liu, D.-Y. Ouyang, and X.-H. He. 2014. VASP Activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation. Edited by Gordon Langsley. PLoS ONE 9 (4): e93547. doi: 10.1371/journal.pone.0093547.
  • Zheng, Q., Y. Liu, W. Liu, F. Ma, Y. I. Zhou, M. Chen, J. Chang, Y. Wang, G. Yang, and G. He. 2014. Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells. Molecular Medicine Reports 10 (1):89–94. doi: 10.3892/mmr.2014.2175.

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