Effect of omega-3 fatty acids supplementation on adipokines: a systematic review and meta-analysis of randomized controlled trials

References

• Abdelhamid, A. S., T. J. Brown, J. S. Brainard, P. Biswas, G. C. Thorpe, H. J. Moore, K. H. Deane,  F. K. AlAbdulghafoor, C. D. Summerbell, H. V.  Worthington, et al. 2020. Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 7 (7) : CD003177.
   Web of Science ®Google Scholar
• Akbari, A.,. Z. Farahnejad, J. Akhtari, M. Abastabar, G. R. Mobini, and A. S. A. Mehbod. 2016. Staphylococcus aureus enterotoxin B down-regulates the expression of transforming growth factor-beta (TGF-β) signaling transducers in human glioblastoma. Jundishapur Journal of Microbiology 9 (5): e27297.
   Web of Science ®Google Scholar
• AlAmmar, W. A., F. H. Albeesh, L. M. Ibrahim, Y. Y. Algindan, L. Z. Yamani, and R. Y. Khattab. 2019. Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: A systematic review. Nutritional Neuroscience 22 (8): 1–11.
   PubMed Web of Science ®Google Scholar
• Bahreini, M., A.-H. Ramezani, F. Shishehbor, and A. Mansoori. 2018. The effect of omega-3 on circulating adiponectin in adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Canadian Journal of Diabetes 42 (5):553–9.
   PubMed Web of Science ®Google Scholar
• Barbosa, M., A. L. T. R. de Melo, and N. R. T. Damasceno. 2017. The benefits of ω-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial. Nutrition 34:7–13.
   PubMed Web of Science ®Google Scholar
• Borges, M. C., F. M. M. Santos, R. W. Telles, M. V. M. Andrade, M. I. T. D. Correia, and C. C. D. Lanna. 2017. Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: A pilot study. Revista Brasileira de Reumatologia 57 (6):526–34.
   Google Scholar
• Calder, P. C. 2006. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. American Journal of Clinical Nutrition 83 (6 Suppl):1505S–1519. S.
   PubMed Web of Science ®Google Scholar
• Chen, L., and X. Xu. 2020. Effect evaluation of the long-term care insurance (LTCI) system on the health Care of the Elderly: A review. Journal of Multidisciplinary Healthcare13: 863–875.
   PubMed Web of Science ®Google Scholar
• Chinnery, H. R., C. Naranjo Golborne, and L. E. Downie. 2017. Omega‐3 supplementation is neuroprotective to corneal nerves in dry eye disease: A pilot study. Ophthalmic and Physiological Optics 37 (4):473–81.
   PubMed Web of Science ®Google Scholar
• D’Angelo, S., M. L. Motti, and R. Meccariello. 2020. ω-3 and ω-6 polyunsaturated fatty acids. Obesity and Cancer. Nutrients 12 (9):2751.
   Web of Science ®Google Scholar
• Derosa, G., A. F. Cicero, E. Fogari, A. D'Angelo, A. Bonaventura, and P. Maffioli. 2011. Effects of n‐3 PUFA on insulin resistance after an oral fat load. European Journal of Lipid Science and Technology 113 (8):950–60.
   Web of Science ®Google Scholar
• Domingo, P., J. M. Gallego-Escuredo, I. Fernández, J. Villarroya, F. Torres, M. del Mar Gutierrez, M. G. Mateo, F. Villarroya, F. Vidal, M. Giralt, and J. C. Domingo. 2018. Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study. Cytokine 105:73–9.
   PubMed Web of Science ®Google Scholar
• Downie, L. E., S. M. Ng, K. B. Lindsley, and E. K. Akpek. 2019. Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease. Cochrane Database of Systematic Reviews 12: CD011016.
   PubMed Web of Science ®Google Scholar
• Dunn, T. N., and S. H. Adams. 2014. Relations between metabolic homeostasis, diet, and peripheral afferent neuron biology. Advances in Nutrition 5 (4):386–93.
   PubMed Web of Science ®Google Scholar
• Emami, S., R. Nekouian, A. Akbari, A. Faraji, V. Abbasi, and S. Agah. 2019. Evaluation of circulating miR-21 and miR-222 as diagnostic biomarkers for gastric cancer. Journal of Cancer Research and Therapeutics 15 (1):115–9.
   PubMed Web of Science ®Google Scholar
• Emami, S. S., A. Akbari, A.-A. Zare, S. Agah, M. Masoodi, A. Talebi, S. Minaeian, A. Fattahi, and F. Moghadamnia. 2019. MicroRNA expression levels and histopathological features of colorectal cancer. Journal of Gastrointestinal Cancer 50 (2):276–84.
   PubMed Web of Science ®Google Scholar
• Eriksdotter, M., I. Vedin, F. Falahati, Y. Freund-Levi, E. Hjorth, G. Faxen-Irving, L.-O. Wahlund, M. Schultzberg, H. Basun, T. Cederholm, and J. Palmblad. 2015. Plasma fatty acid profiles in relation to cognition and gender in Alzheimer’s disease patients during oral omega-3 fatty acid supplementation: The omegad study. Journal of Alzheimer's Disease 48 (3):805–12.
   PubMed Web of Science ®Google Scholar
• Farimani, A. R., M. Hariri, M. Azimi-Nezhad, A. Borji, S. Zarei, and E. Hooshmand. 2018. The effect of n-3 PUFAs on circulating adiponectin and leptin in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Acta Diabetologica 55 (7):641–52.
   PubMed Web of Science ®Google Scholar
• Fritsche, K. L. 2015. The science of fatty acids and inflammation. Advances in Nutrition 6 (3):293S–301S.
   PubMed Web of Science ®Google Scholar
• Gammelmark, A., T. Madsen, K. Varming, S. Lundbye-Christensen, and E. B. Schmidt. 2012. Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects. Nutrition Research 32 (1):15–23.
   PubMed Web of Science ®Google Scholar
• Gharekhani, A., S. Dashti-Khavidaki, M. Lessan-Pezeshki, and M.-R. Khatami. 2016. Potential effects of omega-3 fatty acids on insulin resistance and lipid profile in maintenance hemodialysis patients. Iranian Journal of Kidney Diseases 10 (5):310–8.
   PubMed Web of Science ®Google Scholar
• Ghorabi, S., A. Salari-Moghaddam, E. Daneshzad, O. Sadeghi, L. Azadbakht, and K. Djafarian. 2019. Association between the DASH diet and metabolic syndrome components in Iranian adults. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13 (3):1699–704.
   PubMed Web of Science ®Google Scholar
• Golpour, P., M. Nourbakhsh, M. Mazaherioun, L. Janani, M. Nourbakhsh, and P. Yaghmaei. 2020. Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: A double-blind randomised placebo-controlled clinical trial. Diabetes Research and Clinical Practice 162:108120.
   PubMed Web of Science ®Google Scholar
• Gomes, P. M., W. R. Hollanda-Miranda, R. A. Beraldo, A. V. Castro, B. Geloneze, M. C. Foss, and M. C. Foss-Freitas. 2015. Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes. Nutrition 31 (6):853–7.
   PubMed Web of Science ®Google Scholar
• Gray, B., F. Steyn, P. Davies, and L. Vitetta. 2013. Omega-3 fatty acids: A review of the effects on adiponectin and leptin and potential implications for obesity management. European Journal of Clinical Nutrition 67 (12):1234–42.
   PubMed Web of Science ®Google Scholar
• Hafiane, A., K. Gasbarrino, and S. S. Daskalopoulou. 2019. The role of adiponectin in cholesterol efflux and HDL biogenesis and metabolism. Metabolism 100: 153953.
   PubMedGoogle Scholar
• Haghiac, M., X.-H. Yang, L. Presley, S. Smith, S. Dettelback, J. Minium, M. A. Belury, P. M. Catalano, and S. Hauguel-de Mouzon. 2015. Dietary omega-3 fatty acid supplementation reduces inflammation in obese pregnant women: A randomized double-blind controlled clinical trial. PLoS One 10 (9):e0137309.
   PubMed Web of Science ®Google Scholar
• Haidari, F., M. Tavakoli, H. Heybar, B. Helli, and M. Mohamadshahi. 2015. The effect of omega-3 on the level of serum lipid profile, adipocytokines, and indicator of vascular inflammation in patients diagnosed with myocardial infarction. Journal of Babol University of Medical Sciences 17 (4):7–17.
   Google Scholar
• Hajianfar, H., M. J. Hosseinzadeh, K. M. Ahmad Bahonar, G. R. Askari, M. H. Entezari, A. Keshavarz, and N. Ansarih. 2011. The effect of omega-3 on the serum visfatin concentration in patients with type II diabetes. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences 16 (4):490.
   PubMed Web of Science ®Google Scholar
• Hariri, M., R. Ghiasvand, A. Shiranian, G. Askari, B. Iraj, and A. Salehi‐Abargouei. 2015. Does omega‐3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta‐analysis on randomized controlled clinical trials. Clinical Endocrinology 82 (2):221–8.
   PubMed Web of Science ®Google Scholar
• Harving, F., M. Svensson, A. Flyvbjerg, E. B. Schmidt, K. A. Jørgensen, H. H. Eriksen, and J. H. Christensen. 2015. n-3 polyunsaturated fatty acids and adiponectin in patients with end-stage renal disease. Clinical Nephrology 83 (5):279–85.
   PubMed Web of Science ®Google Scholar
• Hua, L., M. Lei, S. Xue, X. Li, S. Li, and Q. Xie. 2020. Effect of fish oil supplementation combined with high-intensity interval training in newly diagnosed non-obese type 2 diabetes: A randomized controlled trial. Journal of Clinical Biochemistry and Nutrition 66 (2):146–51.
   PubMed Web of Science ®Google Scholar
• Huang, F., B. E. del-Río-Navarro, J. Leija-Martinez, S. Torres-Alcantara, E. Ruiz-Bedolla, L. Hernández-Cadena, A. Barraza-Villarreal, R. Romero-Nava, F. Sanchéz-Muñoz, S. Villafaña, L. A. Marchat, et al. 2019. Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia. Journal of Nutritional Biochemistry 64:162–9.
   PubMed Web of Science ®Google Scholar
• Huerta, A. E., S. Navas‐Carretero, P. L. Prieto‐Hontoria, J. A. Martínez, and M. J. Moreno‐Aliaga. 2015. Effects of α‐lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity 23 (2):313–21.
   PubMed Web of Science ®Google Scholar
• Huerta, A. E., P. L. Prieto-Hontoria, N. Sáinz, J. A. Martinez, and M. J. Moreno-Aliaga. 2015. Supplementation with α-lipoic acid alone or in combination with eicosapentaenoic acid modulates the inflammatory status of healthy overweight or obese women consuming an energy-restricted diet. The Journal of Nutrition 146 (4):889S–96S.
   PubMed Web of Science ®Google Scholar
• Izadi, V., and L. Azadbakht. 2015. Specific dietary patterns and concentrations of adiponectin. Journal of Research in Medical Sciences 20 (2):178–84.
   PubMed Web of Science ®Google Scholar
• Jacobo-Cejudo, M. G., R. Valdés-Ramos, A. L. Guadarrama-López, R.-V. Pardo-Morales, B. E. Martínez-Carrillo, and L. S. Harbige. 2017. Effect of n-3 polyunsaturated fatty acid supplementation on metabolic and inflammatory biomarkers in type 2 diabetes mellitus patients. Nutrients 9 (6):573.
   Web of Science ®Google Scholar
• Jafari Salim, S., S. Alizadeh, M. Djalali, E. Nematipour, and M. Hassan Javanbakht. 2017. Effect of omega-3 polyunsaturated fatty acids supplementation on body composition and circulating levels of follistatin-like 1 in males with coronary artery disease: A randomized double-blind clinical trial. American Journal of Men's Health 11 (6):1758–64.
   PubMed Web of Science ®Google Scholar
• Jafari Nasabian, P., J. Inglis, M. Ave, H. Hebrock, K. Hall, S. Nieto, and J. Ilich. 2017. Relation of adiponectin with body adiposity and bone mineral density in older women. Advances in Nutrition 8 (1):11.
   Google Scholar
• Janczyk, W., D. Lebensztejn, A. Wierzbicka-Rucińska, A. Mazur, J. Neuhoff-Murawska, P. Matusik, and P. Socha. 2015. Omega-3 Fatty acids therapy in children with nonalcoholic Fatty liver disease: A randomized controlled trial. The Journal of Pediatrics 166 (6):1358–1363.
   PubMed Web of Science ®Google Scholar
• Jiang, D., F.-X. Chen, H. Zhou, Y.-Y. Lu, H. Tan, S.-J. Yu, J. Yuan, H. Liu, W. Meng, and Z. B. Jin. 2020. Bioenergetic crosstalk between mesenchymal stem cells and various ocular cells through the intercellular trafficking of mitochondria. Theranostics 10 (16):7260.
   PubMed Web of Science ®Google Scholar
• Jiang, Q., S. Jin, Y. Jiang, M. Liao, R. Feng, L. Zhang, G. Liu, and J. Hao. 2017. Alzheimer’s disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells. Molecular Neurobiology 54 (1):594–600.
   PubMed Web of Science ®Google Scholar
• Johnson, K. O., O. M. Shannon, J. Matu, A. Holliday, T. Ispoglou, and K. Deighton. 2020. Differences in circulating appetite-related hormone concentrations between younger and older adults: A systematic review and meta-analysis. Aging Clinical and Experimental Research 32 (7):1233–1244.
   PubMed Web of Science ®Google Scholar
• Kabir, M., G. Skurnik, N. Naour, V. Pechtner, E. Meugnier, S. Rome, A. Quignard-Boulangé, H. Vidal, G. Slama, K. Clément, M. Guerre-Millo, et al. 2007. Treatment for 2 mo with n− 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: A randomized controlled study. The American Journal of Clinical Nutrition 86 (6):1670–1679.
   PubMed Web of Science ®Google Scholar
• Kang, M., L.-M. Yan, W.-Y. Zhang, Y.-M. Li, A.-Z. Tang, and H.-S. Ou. 2013. Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression. Molecular Biology Reports 40 (8):5027–5034.
   PubMed Web of Science ®Google Scholar
• Karimi, A., K. Majidzadeh-A, Z. Madjd, A. Akbari, L. Habibi, and S. M. Akrami. 2015. Effect of copper sulfate on expression of endogenous L1 retrotransposons in HepG2 cells (hepatocellular carcinoma). Biological Trace Element Research 165 (2):131–134.
   PubMed Web of Science ®Google Scholar
• Khorrami, E., M. J. Hosseinzadeh‐Attar, A. Esmaillzadeh, E. Alipoor, M. Hosseini, Z. Emkanjou, and S. Moradmand. 2020. Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation. Food Science & Nutrition 8 (4):2165–2172.
   PubMed Web of Science ®Google Scholar
• Khoshkam, F., F. Taghian, and K. Jalali Dehkordi. 2018. Effect of eight weeks of supplementation of omega-3 supplementation and TRX training on visfatin and insulin resistance in women with polycystic ovary syndrome. The Iranian Journal of Obstetrics, Gynecology and Infertility 21 (9):58–70.
   Google Scholar
• Kidd, P. M. 2007. Omega-3 DHA and EPA for cognition, behavior, and mood: Clinical findings and structural-functional synergies with cell membrane phospholipids. Alternative Medicine Review 12 (3):207.
   PubMedGoogle Scholar
• Kim, D. H., C. Kim, E. L. Ding, M. K. Townsend, and L. A. Lipsitz. 2013. Adiponectin levels and the risk of hypertension: A systematic review and meta-analysis. Hypertension 62 (1):27–32.
   PubMed Web of Science ®Google Scholar
• Kohli, P., and B. D. Levy. 2009. Resolvins and protectins: Mediating solutions to inflammation. British Journal of Pharmacology 158 (4):960–971.
   PubMed Web of Science ®Google Scholar
• Kontogianni, M. D., A. Vlassopoulos, A. Gatzieva, A.-E. Farmaki, S. Katsiougiannis, D. B. Panagiotakos, and N. Kalogeropoulos, and F. N. Skopouli. 2013. Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults. Metabolism 62 (5):686–693.
   PubMed Web of Science ®Google Scholar
• Lee, T. C., P. Ivester, A. G. Hester, S. Sergeant, L. D. Case, T. Morgan, E. O. Kouba, and F. H. Chilton. 2014. The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lipids in Health and Disease. 13 (1):196.
   PubMedGoogle Scholar
• LeMay-Nedjelski, L., J. K. Mason-Ennis, A. Taibi, E. M. Comelli, and L. U. Thompson. 2018. Omega-3 polyunsaturated fatty acids time-dependently reduce cell viability and oncogenic microRNA-21 expression in estrogen receptor-positive breast cancer cells (MCF-7). International Journal of Molecular Sciences 19 (1):244.
   Web of Science ®Google Scholar
• Liu, G., G. Ren, L. Zhao, L. Cheng, C. Wang, and B. Sun. 2017. Antibacterial activity and mechanism of bifidocin A against Listeria monocytogenes. Food Control 73:854–861.
   Web of Science ®Google Scholar
• Lozovoy, M. A. B., L. D. Bahls, H. K. Morimoto, T. Matsuo, and I. Dichi. 2012. Blood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: Role of adiponectin and nitric oxide. British Journal of Nutrition 108 (8):1435–1442.
   PubMed Web of Science ®Google Scholar
• Machado, A. M., H. de Paula, L. D. Cardoso, and N. M. Costa. 2015. Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. Nutrition 31 (1):90–96.
   PubMed Web of Science ®Google Scholar
• Maher, T., and M. E. Clegg. 2019. Dietary lipids with potential to affect satiety: Mechanisms and evidence. Critical Reviews in Food Science and Nutrition 59 (10):1619–1644.
   PubMed Web of Science ®Google Scholar
• Mandal, C. C., T. Ghosh-Choudhury, N. Dey, G. G. Choudhury, and N. Ghosh-Choudhury. 2012. miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression. Carcinogenesis 33 (10):1897–1908.
   PubMed Web of Science ®Google Scholar
• Manson, J. E., N. R. Cook, I.-M. Lee, W. Christen, S. S. Bassuk, S. Mora, H. Gibson, C. M. Albert, D. Gordon, T. Copeland, et al. 2019. Marine n− 3 fatty acids and prevention of cardiovascular disease and cancer. New England Journal of Medicine 380 (1):23–32.
   PubMed Web of Science ®Google Scholar
• Mazaherioun, M., A. Saedisomeolia, M. H. Javanbakht, F. Koohdani, M. R. Eshraghian, and M. Djalali. 2017. Beneficial effects of n-3 polyunsaturated fatty acids on adiponectin levels and AdipoR gene expression in patients with type 2 diabetes mellitus: A randomized, placebo-controlled, double-blind clinical trial. Archives of Medical Science: AMS 13 (4):716.
   PubMed Web of Science ®Google Scholar
• Mejia-Montilla, J., E. Reyna-Villasmil, L. Domínguez-Brito, C. Naranjo-Rodríguez, D. Noriega-Verdugo, M. Padilla-Samaniego, and V. Vargas-Olalla. 2018. Supplementation with omega-3 fatty acids and plasma adiponectin in women with polycystic ovary syndrome. Endocrinología Diabetes y Nutrición 65 (4):192–199.
   PubMed Web of Science ®Google Scholar
• Meldrum, S. J., N. D'Vaz, K. Simmer, J. A. Dunstan, K. Hird, and S. L. Prescott. 2012. Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: A randomised controlled trial. British Journal of Nutrition 108 (8):1443–1454.
   PubMed Web of Science ®Google Scholar
• Micha, R., J. L. Peñalvo, F. Cudhea, F. Imamura, C. D. Rehm, and D. Mozaffarian. 2017. Association between dietary factors and mortality from heart disease, stroke, and type 2 diabetes in the United States. JAMA 317 (9):912–924.
   PubMed Web of Science ®Google Scholar
• Mizia-Stec, K., M. Haberka, M. Mizia, A. Chmiel, K. Gieszczyk, B. Lasota, J. Janowska, B. Zahorska-Markiewicz, and Z. Gąsior. 2011. N-3 Polyunsaturated fatty acid therapy improves endothelial function and affects adiponectin and resistin balance in the first month after myocardial infarction. Archives of Medical Science: AMS 7 (5):788.
   PubMed Web of Science ®Google Scholar
• Mohammadi, E., M. Rafraf, L. Farzadi, M. Asghari-Jafarabadi, and S. Sabour. 2012. Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Asia Pac. J. Clin. Nutr 21 (4):511.
   PubMed Web of Science ®Google Scholar
• Moreno-Aliaga, M. J., S. Lorente-Cebrian, and J. A. Martinez. 2010. Regulation of adipokine secretion by n-3 fatty acids. Proceedings of the Nutrition Society 69 (3):324–332.
   PubMed Web of Science ®Google Scholar
• Mostowik, M.,. G. Gajos, J. Zalewski, J. Nessler, and A. Undas. 2013. Omega-3 polyunsaturated fatty acids increase plasma adiponectin to leptin ratio in stable coronary artery disease. Cardiovascular Drugs and Therapy 27 (4):289–295.
   PubMed Web of Science ®Google Scholar
• Munro, I. A., and M. L. Garg. 2013. Dietary supplementation with long chain omega-3 polyunsaturated fatty acids and weight loss in obese adults. Obesity Research & Clinical Practice 7 (3):e173–e181.
   PubMed Web of Science ®Google Scholar
• Nadjarzadeh, A., R. Dehghani-Firouzabadi, H. Daneshbodi, M. H. Lotfi, N. Vaziri, and H. Mozaffari-Khosravi. 2015. Effect of Omega-3 supplementation on Visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome. Journal of Reproduction & Infertility 16 (4):212.
   PubMedGoogle Scholar
• Nishi, D., K.-P. Su, K. Usuda, J. P.-C. Chang, K. Hamazaki, T. Ishima, Y. Sano, H. Ito, K. Isaka, Y. Tachibana, et al. 2020. Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women. Brain, Behavior, and Immunity 85:29–34.
   PubMed Web of Science ®Google Scholar
• Oh, P. C., K. K. Koh, I. Sakuma, S. Lim, Y. Lee, S. Lee, S. H. Han, and E. K. Shin. 2014. Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia. International Journal of Cardiology 176 (3):696–702.
   PubMed Web of Science ®Google Scholar
• Pan, D., X.-X. Xia, H. Zhou, S.-Q. Jin, Y.-Y. Lu, and H. Liu. 2020. COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids. Stem Cell Research & Therapy 11 (1):1–12.
   PubMed Web of Science ®Google Scholar
• Paoli, A., T. Moro, G. Bosco, A. Bianco, K. A. Grimaldi, E. Camporesi, and D. Mangar. 2015. Effects of n-3 polyunsaturated fatty acids (ω-3) supplementation on some cardiovascular risk factors with a ketogenic Mediterranean diet. Marine Drugs 13 (2):996–1009.
   PubMed Web of Science ®Google Scholar
• Park, Y., A. Lee, S.-C. Shim, J. H. Lee, J.-Y. Choe, H. Ahn, et al. 2013. Effect of n-3 polyunsaturated fatty acid supplementation in patients with rheumatoid arthritis: A 16-week randomized, double-blind, placebo-controlled, parallel-design multicenter study in Korea. The Journal of Nutritional Biochemistry 24 (7):1367–1372.
   PubMed Web of Science ®Google Scholar
• Paschos, G. K., A. Zampelas, D. B. Panagiotakos, S. Katsiougiannis, B. A. Griffin, V. Votteas, and F. N. Skopouli. 2007. Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. European Journal of Nutrition 46 (6):315–320.
   PubMed Web of Science ®Google Scholar
• Patel, J. V., K. W. Lee, J. Tomson, K. Dubb, E. A. Hughes, and G. Y. Lip. 2007. Effects of omega-3 polyunsaturated fatty acids on metabolically active hormones in patients post-myocardial infarction. International Journal of Cardiology 115 (1):42–45.
   PubMed Web of Science ®Google Scholar
• Payahoo, L., A. Ostadrahimi, N. Farrin, and Y. Khaje-Bishak. 2017. Effects of n-3 polyunsaturated fatty acid supplementation on serum leptin levels, appetite sensations, and intake of energy and macronutrients in obese people: A randomized clinical trial. Journal of Dietary Supplements. 15 (5): 596-605.
   PubMedGoogle Scholar
• Perrier, S., and T. Jarde. 2012. Adiponectin, an anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer. Current Medicinal Chemistry. 19 (32):5501–5512.
   PubMed Web of Science ®Google Scholar
• Piatti, A., A. Croce, D. Mazzacane, G. Traina, L. Ambrosino, L. Boni, L. Lisi, M. Caterina Cascella, and A. Grunberger. 2020. Effect of 2-year nutritional supplementation on progression of age-related macular degeneration. European Journal of Ophthalmology 30 (2):376–381.
   PubMed Web of Science ®Google Scholar
• Poreba, M., M. Mostowik, A. Siniarski, R. Golebiowska-Wiatrak, K. P. Malinowski, M. Haberka, E. Konduracka, J. Nessler, A. Undas, and G. Gajos. 2017. Treatment with high-dose n-3 PUFAs has no effect on platelet function, coagulation, metabolic status or inflammation in patients with atherosclerosis and type 2 diabetes. Cardiovascular Diabetology 16 (1):50.
   PubMedGoogle Scholar
• Qin, Y., Y. Zhou, S.-H. Chen, X.-L. Zhao, L. Ran, X.-L. Zeng, et al. 2015. Fish oil supplements lower serum lipids and glucose in correlation with a reduction in plasma fibroblast growth factor 21 and prostaglandin E2 in nonalcoholic fatty liver disease associated with hyperlipidemia: A randomized clinical trial. PLoS One 10 (7):e0133496.
   PubMed Web of Science ®Google Scholar
• Qu, K., L. Wei, and Q. Zou. 2019. A review of DNA-binding proteins prediction methods. Current Bioinformatics 14 (3):246–254.
   Web of Science ®Google Scholar
• Reseland, J. E., F. Haugen, K. Hollung, K. Solvoll, B. Halvorsen, I. R. Brude, M. S. Nenseter, E. N. Christiansen, and C. A. Drevon. 2001. Reduction of leptin gene expression by dietary polyunsaturated fatty acids. Journal of Lipid Research 42 (5):743–750.
   PubMed Web of Science ®Google Scholar
• Rizza, S., M. Tesauro, C. Cardillo, A. Galli, M. Iantorno, F. Gigli, P. Sbraccia, M. Federici, M. J. Quon, and D. Lauro. 2009. Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes. Atherosclerosis 206 (2):569–574.
   PubMed Web of Science ®Google Scholar
• Sabour, H., A. Norouzi Javidan, S. Latifi, F. Shidfar, R. Heshmat, S.-H. Emami Razavi, M. R. Vafa, and B. Larijani. 2015. Omega-3 fatty acids’ effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial. The Journal of Spinal Cord Medicine 38 (5):599–606.
   PubMed Web of Science ®Google Scholar
• Sam, M. R., M. Tavakoli-Mehr, and R. Safaralizadeh. 2018. Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. Genes & Nutrition 13 (1):1–12.
   PubMedGoogle Scholar
• Sanyal, A. J., M. F. Abdelmalek, A. Suzuki, O. W. Cummings, M. Chojkier, and E.-A. Group. 2014. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology 147 (2):377–384. e371.
   PubMed Web of Science ®Google Scholar
• Satoh, N., A. Shimatsu, K. Kotani, A. Himeno, T. Majima, K. Yamada, T. Suganami, and Y. Ogawa. 2009. Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome. Hypertension Research 32 (11):1004–1008.
   PubMed Web of Science ®Google Scholar
• Sedláček, P., I. Plavinová, J. Langmajerová, J. Dvořáková, J. Novák, L. Trefil, L. Müller, P. Buňatová, V. Zeman, and D. Müllerová. 2018. Effect of n-3 fatty acids supplementation during life style modification in women with overweight. Central European Journal of Public Health 26 (4):265–271.
   PubMed Web of Science ®Google Scholar
• Serhan, C. N., and B. D. Levy. 2018. Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators. Journal of Clinical Investigation 128 (7):2657–2669.
   PubMed Web of Science ®Google Scholar
• Smitka, K., and D. Maresova. 2015. Adipose tissue as an endocrine organ: An update on pro-inflammatory and anti-inflammatory microenvironment. Prague Medical Report 116 (2):87–111.
   PubMedGoogle Scholar
• Sofi, F., I. Giangrandi, F. Cesari, I. Corsani, R. Abbate, G. F. Gensini, and A. Casini. 2010. Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: A preliminary study. International Journal of Food Science and Nutrition 61 (8):792–802.
   PubMed Web of Science ®Google Scholar
• Song, J., M. Hu, C. Li, B. Yang, Q. Ding, C. Wang, and L. Mao. 2018. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: A double-blind randomized controlled trial. Food & Function 9 (6):3235–3243.
   PubMed Web of Science ®Google Scholar
• Spencer, M., B. S. Finlin, R. Unal, B. Zhu, A. J. Morris, L. R. Shipp, J. Lee, R. G. Walton, A. Adu, R. Erfani, et al. 2013. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes 62 (5):1709–1717.
   PubMed Web of Science ®Google Scholar
• Swanson, D., R. Block, and S. A. Mousa. 2012. Omega-3 fatty acids EPA and DHA: Health benefits throughout life. Advances in Nutrition 3 (1):1–7.
   PubMed Web of Science ®Google Scholar
• Tishinsky, J. M., D. W. Ma, and L. E. Robinson. 2011. Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARgamma-dependent manner in human adipocytes. Obesity (Silver Spring) 19 (2):262–268.
   PubMed Web of Science ®Google Scholar
• Tortosa-Caparros, E., D. Navas-Carrillo, F. Marin, and E. Orenes-Pinero. 2017. Anti-inflammatory effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome. Critical Reviews in Food Science and Nutrition 57 (16):3421–3429.
   PubMed Web of Science ®Google Scholar
• Trøseid, M., H. Arnesen, E. M. Hjerkinn, and I. Seljeflot. 2009. Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men. Metabolism 58 (11):1543–1549.
   PubMed Web of Science ®Google Scholar
• Vasselli, J. R., P. J. Scarpace, R. B. Harris, and W. A. Banks. 2013. Dietary components in the development of leptin resistance. Advances in Nutrition 4 (2):164–175.
   PubMed Web of Science ®Google Scholar
• Veleba, J., J. Kopecky, P. Janovska, O. Kuda, O. Horakova, H. Malinska, L. Kazdova, O. Oliyarnyk, V. Skop, J. Trnovska, et al. 2015. Combined intervention with pioglitazone and n-3 fatty acids in metformin-treated type 2 diabetic patients: Improvement of lipid metabolism. Nutrition & Metabolism 12 (1):52.
   PubMedGoogle Scholar
• von Frankenberg, A. D., F. M. Silva, J. C. de Almeida, V. Piccoli, F. V. do Nascimento, M. M. Sost, C. B. Leitão, L. L. Remonti, D. Umpierre, A. F. Reis, et al. 2014. Effect of dietary lipids on circulating adiponectin: A systematic review with meta-analysis of randomised controlled trials. British Journal of Nutrition 112 (8):1235–1250.
   PubMed Web of Science ®Google Scholar
• Vors, C., J. Allaire, S. B. Mejia, T. A. Khan, J. L. Sievenpiper, and B. Lamarche. 2020. Comparing the effects of docosahexaenoic and eicosapentaenoic acids on inflammation markers using pairwise and network meta-analyses of randomized controlled trials. Advances in Nutrition 12 (1): 128–140.
   Web of Science ®Google Scholar
• Wang, Y., X. Wang, W. B. Lau, Y. Yuan, D. Booth, J. J. Li, R. Scalia, K. Preston, E. Gao, W. Koch, and X.-L. Ma. 2014. Adiponectin inhibits tumor necrosis factor-alpha-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. Circulation Research 114 (5):792–805.
   PubMed Web of Science ®Google Scholar
• Watson, H., and C. Stackhouse. 2020. Omega‐3 fatty acid supplementation for cystic fibrosis. Cochrane Database of Systematic Reviews 4: CD002201..
   Google Scholar
• Weihe, P., J. Spielmann, H. Kielstein, J. Henning-Klusmann, and S. Weihrauch-Bluher. 2020. Childhood Obesity and Cancer Risk in Adulthood. Current Obesity Reports 9 (3):204–212.
   PubMed Web of Science ®Google Scholar
• Wolbrink, D. R., J. R. Grundsell, B. Witteman, M. van de Poll, H. C. van Santvoort, E. Issa, A. Dennison, H. V. Goor, and M. G. Besselink. 2019. Are omega-3 fatty acids safe and effective in acute pancreatitis or sepsis? A systematic review and meta-analysis. Clinical Nutrition 39 (9): 2686–2694.
   PubMed Web of Science ®Google Scholar
• Wong, A. T., D. C. Chan, P. H. R. Barrett, L. A. Adams, and G. F. Watts. 2013. Supplementation with n3 fatty acid ethyl esters increases large and small artery elasticity in obese adults on a weight loss diet. The Journal of Nutrition 143 (4):437–441.
   PubMed Web of Science ®Google Scholar
• Wu, J. H., L. E. Cahill, and D. Mozaffarian. 2013. Effect of fish oil on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials. The Journal of Clinical Endocrinology & Metabolism 98 (6):2451–2459.
   PubMed Web of Science ®Google Scholar
• Xu, X., and L. Chen. 2019. Projection of long-term care costs in China, 2020–2050: Based on the Bayesian quantile regression method. Sustainability 11 (13):3530.
   Web of Science ®Google Scholar
• Yamamoto, T., Y. Kajikawa, S. Otani, Y. Yamada, S. Takemoto, M. Hirota, M. Ikeda, H. Iwagaki, S. Saito, and T. Fujiwara. 2014. Protective effect of eicosapentaenoic acid on insulin resistance in hyperlipidemic patients and on the postoperative course of cardiac surgery patients: The possible involvement of adiponectin. Acta Medica Okayama 68 (6):349–361.
   PubMed Web of Science ®Google Scholar
• Zhu, S., X. Wang, Z. Zheng, X.-E. Zhao, Y. Bai, and H. Liu. 2020. Synchronous measuring of triptolide changes in rat brain and blood and its application to a comparative pharmacokinetic study in normal and Alzheimer’s disease rats. Journal of Pharmaceutical and Biomedical Analysis 185:113263.
   PubMed Web of Science ®Google Scholar
• Zou, Q., P. Xing, L. Wei, and B. Liu. 2019. Gene2vec: Gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA. RNA 25 (2):205–218.
   PubMed Web of Science ®Google Scholar