The role and mechanism of citrus flavonoids in cardiovascular diseases prevention and treatment

References

• Ahotupa, M. 2017. Oxidized lipoprotein lipids and atherosclerosis. Free Radical Research 51 (4):1–27. doi: 10.1080/10715762.2017.1319944.
   PubMed Web of Science ®Google Scholar
• Alam, M. A., K. Kauter, and L. Brown. 2013. Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients 5 (3):637–50. doi: 10.3390/nu5030637.
   PubMed Web of Science ®Google Scholar
• Ana, L. R. F., M. Monteiro, M. A. T. Adorno, I. K. Sakamoto, and K. Sivieria. 2016. An exploratory study on the influence of orange juice on gut microbiota using a dynamic colonic model. Food Research International 84:160–9. doi: 10.1016/j.foodres.2016.03.028.
   Web of Science ®Google Scholar
• Andlauer, W., C. Stumpf, and P. Fürst. 2001. Intestinal absorption of rutin in free and conjugated forms 1 1 Abbreviations: ESI−, electrospray ionization. Biochemical Pharmacology 62 (3):369–74. doi: 10.1016/S0006-2952(01)00638-4.
   PubMed Web of Science ®Google Scholar
• Aquino, D., and R. 2005. Cholesterol-reducing flavonoids found in citrus peels. Agricultural Research 53 (9):16.
   Google Scholar
• Aura, A. M., K. A. O'leary, G. Williamson, M. Ojala, M. Bailey, R. Puupponen-Pimiä, A.-M. Nuutila, K.-M. Oksman-Caldentey, and K. Poutanen. 2002. Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro. Journal of Agricultural & Food Chemistry 50 (6):1725–30. doi: 10.1021/jf0108056.
   PubMed Web of Science ®Google Scholar
• Baselga-Escudero, L., A. D. Pascual-Serrano, A. Ribas-Latre, E. Casanova, M. J. Salvadó, L. Arola, A. Arola-Arnal, and C. Bladé. 2015. Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet–induced obese rats. Nutrition Research 35 (4):337–45. doi: 10.1016/j.nutres.2015.02.008.
   PubMed Web of Science ®Google Scholar
• Beretz, A., and J. P. Cazenave. 1988. The effect of flavonoids on blood-vessel wall interactions. Progress in Clinical & Biological Research 280:187–200.
   PubMedGoogle Scholar
• Bieger, J., R. Cermak, R. Blank, V. C. de Boer, P. C. Hollman, J. Kamphues, and S. Wolffram. 2008. Tissue distribution of quercetin in pigs after long-term dietary supplementation. Journal of Nutrition 138 (8):1417. doi: 10.1111/j.1365-277X.2008.00867.x.
   PubMed Web of Science ®Google Scholar
• Bok, S. H., S. H. Lee, Y. B. Park, K. H. Bae, K. H. Son, T. S. Jeong, and M. S. Choi. 1999. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: Cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. Journal of Nutrition 129 (6):1182–5. doi: 10.1046/j.1365-277x.1999.00160.x.
   PubMed Web of Science ®Google Scholar
• Buscemi, S., G. Rosafio, G. Arcoleo, A. Mattina, B. Canino, M. Montana, S. Verga, and G. Rini. 2012. Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk. American Journal of Clinical Nutrition 95 (5):1089–95. doi: 10.3945/ajcn.111.031088.
   PubMed Web of Science ®Google Scholar
• Caesar, R., F. Fak, and F. Backhed. 2010. Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. Journal of Internal Medicine 268 (4):320–8. doi: 10.1111/j.1365-2796.2010.02270.x.
   PubMed Web of Science ®Google Scholar
• Carresi, C., V. Musolino, M. Gliozzi, J. Maiuolo, M. Rocco, S. Nucera, A. Maretta, D. Sergi, S. Muscoli, S. Gratteri, et al. 2018. Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kit pos CD45 neg CD31 neg cardiac stem cell activation. Journal of Molecular & Cellular Cardiology. 119:10–18. doi: 10.1016/j.yjmcc.2018.04.007.
   PubMed Web of Science ®Google Scholar
• Cassidy, A., E. B. Rimm, E. J. O'Reilly, G. Logroscino, C. Kay, S. E. Chiuve, and K. M. Rexrode. 2012. Dietary flavonoids and risk of stroke in women. Stroke 43 (4):946. doi: 10.1161/STROKEAHA.111.637835.
   PubMed Web of Science ®Google Scholar
• Cesar, T. B., N. P. Aptekmann, M. P. Araujo, C. C. Vinagre, and R. C. Maranhão. 2010. Orange juice decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects. Nutrition Research 30 (10):689–94. doi: 10.1016/j.nutres.2010.09.006.
   PubMed Web of Science ®Google Scholar
• Chen, X. M., A. R. Tait, and D. D. Kitts. 2017. Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities. Food Chemistry 218:15–21. doi: 10.1016/j.foodchem.2016.09.016.
   PubMed Web of Science ®Google Scholar
• Cho, K. W., Y. O. Kim, J. E. Andrade, J. R. Burgess, and Y. C. Kim. 2011. Dietary naringenin increases hepatic peroxisome proliferators-activated receptor alpha protein expression and decreases plasma triglyceride and adiposity in rats. European Journal of Nutrition 50 (2):81–8. doi: 10.1007/s00394-010-0117-8.
   PubMed Web of Science ®Google Scholar
• Chun, O. K., S. J. Chung, K. J. Claycombe, and W. O. Song. 2008. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. Journal of Nutrition 138 (4):753–60. doi: 10.1111/j.1365-277X.2008.00856x.
   PubMed Web of Science ®Google Scholar
• Clark, J. L., Z. Peter, and C. G. Taylor. 2015. Efficacy of flavonoids in the management of high blood pressure. Nutrition Reviews 73 (12):799–822. doi: 10.1093/nutrit/nuv048.
   PubMed Web of Science ®Google Scholar
• Crespy, V., C. Morand, C. Besson, C. Manach, C. Demigne, and C. Remesy. 2002. Quercetin, but not its glycosides, is absorbed from the rat stomach. Journal of Agricultural & Food Chemistry 50 (3):618–21. doi: 10.1021/jf010919h.
   PubMed Web of Science ®Google Scholar
• Da, P. E., C. Barbara, C. Chiara, T. Lara, M. Alma, C. Vincenzo, and C. Martini. 2017. The citrus flavanone naringenin protects myocardial cells against age-associated damage. Oxidative Medicine & Cellular Longevity 2017:1–12. doi: 10.1155/2017/9536148.
   Web of Science ®Google Scholar
• Del Río, J. A., P. Gómez, A. G. Baidez, M. C. Arcas, J. M. Botía, and A. Ortuño. 2004. Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of citrus sinensis (Cv. Valencia Late) fruits against phytophthora citrophthora. Journal of Agricultural & Food Chemistry 52 (7):1913–7. doi: 10.1021/jf035038k.
   PubMed Web of Science ®Google Scholar
• Demonty, I., Y. Lin, Y. E. M. P. Zebregs, M. A. Vermeer, D. K. H. C. Van, M. Jakel, and E. A. Trautwein. 2010. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. Journal of Nutrition 140 (9):1615–20. doi: 10.3945/jn.110.124735.
   PubMed Web of Science ®Google Scholar
• Ding, X., L. Guo, Y. Zhang, S. Fan, M. Gu, Y. Lu, D. Jiang, Y. Li, C. Huang, and Z. Zhou. 2013. Extracts of pomelo peels prevent high-fat diet-induced metabolic disorders in c57bl/6 mice through activating the PPARalpha and GLUT4 pathway. PLoS ONE. 8 (10):e77915. doi: 10.1371/journal.pone.0077915.
   PubMed Web of Science ®Google Scholar
• Ding, M., L. Liu, T. Zhang, N. Tao, X. Wang, and J. Zhong. 2021. Effect of interfacial layer number on the storage stability and in vitro digestion of fish oil-loaded multilayer emulsions consisting of gelatin particle and polysaccharides. Food Chemistry 336:127686. doi: 10.1016/j.foodchem.2020.127686.
   PubMed Web of Science ®Google Scholar
• Dong, Y., V. V. Undyala, R. A. Gottlieb, R. M. Mentzer, and K. Przyklenk. 2010. Autophagy: Definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury. Journal of Cardiovascular Pharmacology & Therapeutics 15 (3):220–30. doi: 10.1177/1074248410370327.
   PubMed Web of Science ®Google Scholar
• Duan, L., C. Min, Y. Niu, X. Chi, X. Liu, J. Fan, H. Fan, Y. Chang, and W. Yang. 2017. Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c. International Journal of Biological Sciences 13 (3):349–57. doi: 10.7150/ijbs.16635.
   PubMed Web of Science ®Google Scholar
• Duda-Chodak, A. 2012. The inhibitory effect of polyphenols on human gut microbiota. Journal of Physiology & Pharmacology 63 (5):497–503. doi:10.1002/cphy.c110065.
   PubMed Web of Science ®Google Scholar
• FAO. 2017. Market and Policy Analysis of raw materials, horticulture and tropical (RAMHOT) products team. Quebec: Food and Agriculture Organization of the United Nations.
   Google Scholar
• Felgines, C., S. Talavera, O. Texier, C. Besson, V. Fogliano, J. L. Lamaison, L. L. Fauci, G. Galvano, C. Rémésy, and F. Galvano. 2006. Absorption and metabolism of red orange juice anthocyanins in rats. British Journal of Nutrition 95 (5):898–904. doi: 10.1079/BJN20061728.
   PubMed Web of Science ®Google Scholar
• Feng, J., X. Chen, S. Lu, W. Li, D. Yang, W. Su, X. Wang, and J. Shen. 2018. Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation. Molecular Neurobiology 55:9029–42. doi: 10.1007/s12035-018-1027-7.
   PubMed Web of Science ®Google Scholar
• Garcia-Rios, A., A. Torres-Pena, F. Perez-Jimenez, and P. Perez-Martinez. 2017. Gut microbiota: A new marker of cardiovascular disease. Current Pharmaceutical Design 23 (22):3233–38. doi: 10.2174/1381612823666170317144853.
   PubMed Web of Science ®Google Scholar
• Garelnabi, M., and H. Mahini. 2014. Modulation of microRNA 21, 125 b and 451 expression by quercetin intake and exercise in mice fed atherogenic diet. Biomedicine & Preventive Nutrition 4 (3):359–63. doi: 10.1016/j.bionut.2014.04.005.
   Google Scholar
• Gaydou, E. M., J. P. Bianchini, and R. P. Randriamiharisoa. 1987. Orange and mandarin peel oils differentiation using polymethoxylated flavone composition. Journal of Agricultural & Food Chemistry 35 (4):525–9. doi: 10.1021/jf00076a021.
   Web of Science ®Google Scholar
• Gbaj, M. A.,Sadawe, I. A.Meiqal, N. H.Bensaber, S. M.Gbaj, A. M.Maamar, M. S., andHermann, A. 2019. An in vivo study for the effect of Citrus reticulata (Rutaceae) fruit peels extracts on the onset of toxicity of Cerastes cel. Drug Designing and Intellectual Properties International Journal 3 (1):279-280. doi:10.32474/DDIPIJ.2019.02.000153.
   Google Scholar
• Geleijnse, J. M., L. J. Launer, A. Hofman, H. A. P. Pols, and J. C. M. Witteman. 1999. Tea flavonoids may protect against atherosclerosis the Rotterdam study. Archives of Internal Medicine 159 (18):2170–4. doi: 10.1001/archinte.159.18.2170.
   PubMedGoogle Scholar
• Gerard, G., S. Guy, G. Charlotte, J. Z. Moises, R. Katleen, and V. C. John. 2015. Flavonoid interactions during digestion, absorption, distribution and metabolism: A sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity. Drug Metabolism Reviews 47 (2):175–90. doi: 10.3109/03602532.2014.1003649.
   PubMed Web of Science ®Google Scholar
• Gradolatto, A., M. C. Canivenclavier, J. P. Basly, M. Siess, and C. Teyssier. 2004. Metabolism of apigenin by rat liver phase I and phase II enzymes and by isolated perfused rat liver. Drug Metabolism & Disposition the Biological Fate of Chemicals 32 (1):58. doi: 10.1124/dmd.32.1.58.
   PubMed Web of Science ®Google Scholar
• Graf, B. A., C. Ameho, G. G. Dolnikowski, P. E. Milbury, C. Y. Chen, and J. B. Blumberg. 2006. Rat Gastrointestinal tissues metabolize quercetin. Journal of Nutrition 136 (1):39–44. doi: 10.1007/s00425-004-1471-7.
   PubMed Web of Science ®Google Scholar
• Grassi, D., and G. D. G. C. 2009. Flavonoids, vascular function and cardiovascular protection. Current Pharmaceutical Design 15 (10):1072–84. doi: 10.2174/138161209787846982.
   PubMed Web of Science ®Google Scholar
• Guo, Y. M., C. M. Guo, S. Q. Liu, H. S. Yu, and M. Z. Sun. 2005. 2012. Structure-function study of flavonoid phytochemicals on platelet aggregation. Journal of Dalian Medical University 34 (5):424–7. doi: 10.4271/01-0381.
   Google Scholar
• Gwiazdowska, D., K. Jus, J. Jasnowska-Malecka, and K. Kluczynska. 2015. The impact of polyphenols on Bifidobacterium growth. Acta Biochimica Polonica 62 (4):895–901. doi: 10.18388/abp.2015_1154.
   PubMed Web of Science ®Google Scholar
• Hertog, M. G., E. J. Feskens, P. C. Hollman, M. B. Katan, and D. Kromhout. 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 342 (8878):1007–11. doi: 10.1016/0140-6736(93)92876-U.
   PubMed Web of Science ®Google Scholar
• Hirai, S., Y. I. Kim, T. Goto, M. S. Kang, M. Yoshimura, A. Obata, R. Yu, and T. Kawada. 2007. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sciences 81 (16):1279. doi: 10.1016/j.lfs.2007.09.001.
   Web of Science ®Google Scholar
• Hiramitsu, M., Y. Shimada, J. Kuroyanagi, T. Inoue, T. Katagiri, L. Zang, Y. Nishimura, N. Nishimura, and T. Tanaka. 2014. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Scientific Reports 4:3708. doi: 10.1038/srep03708.
   PubMed Web of Science ®Google Scholar
• Hoek-van den Hil, E. F., E. M. van Schothorst, I. van der Stelt, H. J. M. Swarts, M. van Vliet, T. Amolo, J. J. M. Vervoort, D. Venema, P. C. H. Hollman, I. M. C. M. Rietjens, et al. 2015. Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice. Genes & Nutrition 10:23. doi: 10.1007/s12263-015-0469-z.
   Web of Science ®Google Scholar
• Hollman, P. C. H. 2004. Absorption, bioavailability, and metabolism of flavonoids. Archives of Physiology & Biochemistry 42 (s1):74–83. doi: 10.1080/13880200490893492.
   Google Scholar
• Horiba, T., I. Nishimura, Y. Nakai, K. Abe, and R. Sato. 2010. Naringenin chalcone improves adipocyte functions by enhancing adiponectin production. Molecular & Cellular Endocrinology 323 (2):208–14. doi: 10.1016/j.mce.2010.03.020.
   PubMed Web of Science ®Google Scholar
• Hu, Y. W., P. Zhang, J. Y. Yang, J. L. Huang, X. Ma, S. F. Li, J.-Y. Zhao,Y.-R. Hu, Y.-C. Wang, J.-J. Gao, et al. 2014. Nur77 decreases atherosclerosis progression in apoE/mice fed a high-fat/high-cholesterol diet. PLoS ONE. 9 (1):e87313. doi: 10.1371/journal.pone.0087313.
   PubMed Web of Science ®Google Scholar
• Jeon, S. M., B. P. Yong, and M. S. Choi. 2004. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. Clinical Nutrition 23 (5):1025–34. doi: 10.1016/j.clnu.2004.01.006.
   PubMed Web of Science ®Google Scholar
• Joshipura, K. J. 1999. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282 (13):1233. doi: 10.1001/jama.282.13.1233.
   PubMed Web of Science ®Google Scholar
• Julia, A. M., E. E. Mulvihill, B. G. Sutherland, D. E. Telford, C. G. Sawyez, S. L. Felder, S. Chhoker, J. Y. Edwards, R. Gros, and M. W. Huff. 2012. Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis inLdlr−/−mice. Journal of Lipid Research 54 (3):711–24. doi: 10.1194/jlr.M032631.
   PubMed Web of Science ®Google Scholar
• Jung, U. J., H. J. Kim, J. S. Lee, M. K. Lee, H. O. Kim, E. J. Park, H. K. Kim, T. S. Jeong, and M. S. Choi. 2003. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clinical Nutrition 22 (6):561–8. doi: 10.1016/S0261-5614(03)00059-1.
   PubMed Web of Science ®Google Scholar
• Jung, U. J., M. K. Lee, Y. B. Park, M. A. Kang, and M. S. Choi. 2006. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. International Journal of Biochemistry and Cell Biology 38 (7):1134–45. doi: 10.1016/j.biocel.2005.12.002.
   PubMed Web of Science ®Google Scholar
• Kaeko, M., S. Sumie, M. Sayuri, I. Toru, O. Akio, K. Mamoru, and J. Terao. 2002. Unique uptake and transport of isoflavone aglycones by human intestinal Caco-2 cells: Comparison of isoflavonoids and flavonoids. Journal of Nutrition 7 (7):1956. doi: 10.1016/j.postharvbio.2004.03.010.
   Google Scholar
• Kalaany, N. Y., and D. J. Mangelsdorf. 2006. LXRs and FXR: The Yin and Yang of cholesterol and fat metabolism. Annual Review of Physiology 68 (1):159–91. doi: 10.1146/annurev.physiol.68.033104.152158.
   PubMedGoogle Scholar
• Kattoor, A. J., S. H. Kanuri, and J. L. Mehta. 2018. Role of ox-LDL and LOX-1 in atherogenesis. Current Medicinal Chemistry 25 (9):1693–700. doi: 10.2174/0929867325666180508100950.
   Google Scholar
• Khan, M. K., and O. Dangles. 2014. A comprehensive review on flavanones, the major citrus polyphenols. Journal of Food Composition & Analysis 33 (1):85–104. doi: 10.1016/j.jfca.2013.11.004.
   Web of Science ®Google Scholar
• Kim, H. K., T. S. Jeong, M. K. Lee, B. P. Yong, and M. S. Choi. 2003. Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clinica Chimica Acta 327 (1-2):137. doi: 10.1016/S0009-8981(02)00344-3.
   Web of Science ®Google Scholar
• Kim, D. H., S. Y. Kim, S. Y. Park, and M. J. Han. 1999. Metabolism of quercitrin by human intestinal bacteria and its relation to some biological activities. Biological & Pharmaceutical Bulletin 22 (7):749–51. doi: 10.1248/bpb.22.749.
   PubMed Web of Science ®Google Scholar
• Kim, H. J., G. T. Oh, Y. B. Park, M. K. Lee, H. J. Seo, and M. S. Choi. 2004. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. Life Sciences 74 (13):1621–34. doi: 10.1016/j.lfs.2003.08.026.
   PubMed Web of Science ®Google Scholar
• Kimura, O., C. Ohta, N. Koga, K. Haraguchi, Y. Kato, and T. Endo. 2014. Carrier-mediated uptake of nobiletin, a citrus polymethoxyflavonoid, in human intestinal Caco-2 cells. Food Chemistry 154 (1):145–50. doi: 10.1016/j.foodchem.2013.12.069.
   PubMedGoogle Scholar
• Kohno, S., A. L. Keenan, J. M. Ntambi, and M. Miyazaki. 2018. Lipidomic insight into cardiovascular diseases. Biochemical & Biophysical Research Communications 540 (3):590–5. doi: 10.1016/j.bbrc.2018.04.106.
   Google Scholar
• Kou, M. C., S. H. Fu, J. H. Yen, C. Y. Weng, S. Li, C. T. Ho, and M. J. Wu. 2013. Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,5,6,7,8,3',4'-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor. Food Function 4 (4):602–9. doi: 10.1039/c3fo30301b.
   PubMed Web of Science ®Google Scholar
• Kou, X. H., M. F. Zhu, D. Chen, Y. Lu, H. Z. Song, J. L. Ye, and L. F. Yue. 2012. Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. British Journal of Pharmacology 165 (8):2692–706. doi: 10.1111/j.1476-5381.2011.01727.x.
   PubMed Web of Science ®Google Scholar
• Kromhout, D. 1999. Serum cholesterol in cross-cultural perspective. The Seven Countries Study. Acta Cardiologica 54 (3):155–8. doi: 10.1016/S0002-9149(99)00180-0.
   PubMed Web of Science ®Google Scholar
• Kumar Sharma, A., S. Bharti, S. Ojha, J. Bhatia, N. Kumar, R. Ray, S. Kumari, and D. S. Arya. 2011. Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. British Journal of Nutrition 106 (11):1713–23. doi: 10.1017/S000711451100225X.
   PubMed Web of Science ®Google Scholar
• Kurowska, E. M., and J. A. Manthey. 2004. Hypolipidemic Effects and Absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. Journal of Agricultural and Food Chemistry 52 (10):2879–86. doi: 10.1021/jf035354z.
   PubMed Web of Science ®Google Scholar
• Kurowska, E. M., J. A. Manthey, A. Casaschi, and A. G. Theriault. 2004. Modulation of hepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids 39 (2):143–51. doi: 10.1007/s11745-004-1212-8.
   PubMed Web of Science ®Google Scholar
• Lee, Y. S., M. Asai, S. S. Choi, T. Yonezawa, and B. Y. Cha. 2014. Nobiletin prevents body weight gain and bone loss in ovariectomized C57BL/6J mice. Pharmacology & Pharmacy 5 (10):959–65. doi: 10.4236/pp.2014.510108.
   Google Scholar
• Lee, Y. S., B. Y. Cha, S. S. Choi, B. K. Choi, T. Yonezawa, T. Teruya, K. Nagai, and J.-T. Woo. 2013. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. Journal of Nutritional Biochemistry 24 (1):156–62. doi: 10.1016/j.jnutbio.2012.03.014.
   PubMed Web of Science ®Google Scholar
• Lee, C. H., T. S. Jeong, Y. K. Choi, B. H. Hyun, G. T. Oh, & E. H. Kim, J.-R. Kim, J.-I. Han, and S.-H. Bok. 2001. Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochemical and Biophysical Research Communications 284 (3):681–8. doi: 10.1006/bbrc.2001.5001.
   PubMed Web of Science ®Google Scholar
• Lee, S. M., J. Moon, Y. Cho, J. H. Chung, and M. J. Shin. 2013. Quercetin up-regulates expressions of peroxisome proliferator-activated receptor gamma, liver X receptor alpha, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line. Nutrition Research 33 (2):136–43. doi: 10.1016/j.nutres.2012.11.010.
   PubMed Web of Science ®Google Scholar
• Lee, M. K., S. S. Moon, S. E. Lee, S. H. Bok, T. S. Jeong, Y. B. Park, and M.-S. Choi. 2003. Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats. Bioorganic & Medicinal Chemistry 11 (3):393–8. doi: 10.1016/S0968-0896(02)00441-8.
   PubMed Web of Science ®Google Scholar
• Lemos, V. S., M. R. Freitas, B. Muller, Y. D. Lino, and S. F. Crtes. 1999. Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid. European Journal of Pharmacology 386 (1):41–6. doi: 10.1016/S0014-2999(99)00747-5.
   PubMed Web of Science ®Google Scholar
• Li, X., X. Hu, J. Wang, W. Xu, C. Yi, R. Ma, and H. Jiang. 2018. Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. International Journal of Molecular Medicine 42 (4):1917–24. doi: 10.3892/ijmm.2018.3794.
   PubMed Web of Science ®Google Scholar
• Lin, N., T. Sato, Y. Takayama, Y. Mimaki, Y. Sashida, M. Yano, and A. Ito. 2003. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochemical Pharmacology 65 (12):2065–71. doi: 10.1016/S0006-2952(03)00203-X.
   PubMed Web of Science ®Google Scholar
• Lin, Y., M. A. Vermeer, W. Bos, L. Van Buren, E. Schuurbiers, S. Miret-Catalan, and E. A. Trautwein. 2011. Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing ApoB secretion. Journal of Agricultural & Food Chemistry 59 (9):4496–503. doi: 10.1021/jf1044475.
   PubMed Web of Science ®Google Scholar
• Lin, H., Z. Zhou, W. Zhong, P. Huang, N. Ma, Y. Zhang, C. Zhou, Y. Lai, S, Huang, H. An, et al. 2017. Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae. Oncology Reports 38 (5):2877–84. doi: 10.3892/or.2017.5965.
   PubMed Web of Science ®Google Scholar
• Li, S., S. Sang, M. H. Pan, C. S. Lai, C. Y. Lo, C. S. Yang, and C.-T. Ho. 2007. Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. Bioorganic & Medicinal Chemistry Letters 17 (18):5177–81. doi: 10.1016/j.bmcl.2007.06.096.
   PubMed Web of Science ®Google Scholar
• Liu, X., N. Wang, S. Fan, X. Zheng, Y. Yang, Y. Zhu, Y. Lu, Q. Chen, H. Zhou, and J. Zheng. 2016. The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway. Scientific Reports 6 (1):39735. doi: 10.1038/srep39735.
   PubMedGoogle Scholar
• Li, H., X. Zhao, Y. Ma, G. Zhai, L. Li, and H. Lou. 2009. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release 133 (3):238–44. doi: 10.1016/j.jconrel.2008.10.002.
   PubMed Web of Science ®Google Scholar
• Lo, Y. H., M. H. Pan, S. Li, J. H. Yen, M. C. Kou, C. T. Ho, and M.-J. Wu. 2010. Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells. Biochimica Et Biophysica Acta 1801 (2):114–26. doi: 10.1016/j.bbalip.2009.10.002.
   PubMed Web of Science ®Google Scholar
• Lu, W. J., K. C. Lin, C. P. Liu, C. Y. Lin, H. C. Wu, D. S. Chou, P. Geraldine, S.-Y. Huang, C.-Y. Hsieh, and J.-R. Sheu. 2015. Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies. Journal of Nutritional Biochemistry 28:1–8. doi: 10.1016/j.jnutbio.2015.09.024.
   PubMed Web of Science ®Google Scholar
• Ma, S., Y. Wang, Y. Chen, and F. Cao. 2015. The role of the autophagy in myocardial ischemia/reperfusion injury. Biochimica Et Biophysica Acta 1852 (2):271–6. doi: 10.1016/j.bbadis.2014.05.010.
   PubMed Web of Science ®Google Scholar
• Mahato, N., M. Sinha, K. Sharma, R. Koteswararao, and M. H. Cho. 2019. Modern extraction and purification techniques for obtaining high purity food-grade bioactive compounds and value-added co-products from citrus wastes. Foods 8 (11): 523. doi: 10.3390/foods8110.
   PubMed Web of Science ®Google Scholar
• Mahmoudi, M., N. Curzen, and P. J. Gallagher. 2007. Atherogenesis: The role of inflammation and infection. Histopathology 50 (5):535–46. doi: 10.1111/j.1365-2559.2006.02503.x.
   PubMed Web of Science ®Google Scholar
• Manthey, J. A., N. Guthrie, and K. Grohmann. 2001. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Current Medicinal Chemistry 8 (2): 135. doi: 10.2174/0929867013373723.
   PubMed Web of Science ®Google Scholar
• Mari, N., O. Mana, O. Takuo, N. Kyoko, K. Hisanori, M. Takumi, K. Abe, and S. Kobayashi. 2014. Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann–pick C1-like 1 in Caco-2 cells and rats. PLoS ONE. 9 (5):e97901. doi: 10.1371/journal.pone.0097901.
   PubMed Web of Science ®Google Scholar
• Mas-Capdevila, A., J. Teichenne, C. Domenech-Coca, A. Caimari, B. J. Del, X. Escote, and A. Crescenti. 2020. Effect of hesperidin on cardiovascular disease risk factors: The role of intestinal microbiota on hesperidin bioavailability. Nutrients 12 (5):1488. doi: 10.3390/nu1205.
   PubMed Web of Science ®Google Scholar
• Maxwell, R. J. S. 1997. Anti-oxidant therapy: Does it have a role in the treatment of human disease? Expert Opinion on Investigational Drugs 6 (3):211–36. doi: 10.1517/13543784.6.3.211.
   PubMedGoogle Scholar
• Melania, M., P. Lorenza, and B. G. Franco. 2010. Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. Endocrine Reviews 6 (6):817. doi: 10.1210/er.2009-0030.
   Google Scholar
• Milenkovic, D., C. Deval, C. Dubray, A. Mazur, and C. Morand. 2011. Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: A randomized controlled cross-over study. PLoS ONE. 6 (11):e26669. doi: 10.1371/journal.pone.0026669.
   PubMed Web of Science ®Google Scholar
• Minchin, P. R. 1987. An evaluation of the relative robustness of techniques for ecological ordination. Vegetatio 69 (1-3):89–107. doi: 10.1007/BF00038690.
   Google Scholar
• Mink, P. J., C. G. Scrafford, L. M. Barraj, H. Lisa, C. P. Hong, J. A. Nettleton, and D. R. Jacobs Jr. 2007. Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal women. American Journal of Clinical Nutrition 3 (3):895–909. doi: 10.1556/AAlim.36.2007.1.14.
   Google Scholar
• Morin, B., L. A. Nichols, K. M. Zalasky, J. W. Davis, J. A. Manthey, and L. J. Holland. 2008. The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. Journal of Nutrition 138 (7):1274–81. doi: 10.3164/jcbn.2008042.
   PubMed Web of Science ®Google Scholar
• Mulvihill, E. E., E. M. Allister, B. G. Sutherland, D. E. Telford, C. G. Sawyez, J. Y. Edwards, J. M. Markle, R. A. Hegele, and M. W. Huff. 2009. Naringenin prevents dyslipidemia, hpolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 58 (10):2198–210. doi: 10.2337/db09-0634.
   PubMed Web of Science ®Google Scholar
• Mulvihill, E. E., J. M. Assini, J. K. Lee, E. M. Allister, B. Sutherland, J. B. Koppes, C. G. Sawyez, J. Y. Edwards, D. E. Telford, A. Charbonneau, et al. 2011. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes 60 (5):1446–57. doi: 10.2337/db10-0589.
   PubMed Web of Science ®Google Scholar
• Mulvihill, E. E., and M. W. Huff. 2012. Protection from metabolic dysregulation, obesity, and atherosclerosis by Citrus flavonoids: Activation of hepatic PGC1alpha-mediated fatty acid oxidation. PPAR Research 2012:857142. doi: 10.1155/2012/857142.
   PubMed Web of Science ®Google Scholar
• Murota, K., S. Shimizu, H. Chujo, J. H. Moon, and J. Terao. 2000. Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. Archives of Biochemistry and Biophysics 384 (2):391–7. doi: 10.1006/abbi.2000.2123.
   PubMed Web of Science ®Google Scholar
• Musso, G., R. Gambino, and M. Cassader. 2009. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Progress in Lipid Research 48 (1):26. doi: 10.1016/j.plipres.2008.08.001.
   Web of Science ®Google Scholar
• Nabavi, S., Fazel, Morabito, S. Sanches-Silva, A. Mocan, S. F. Nabavi, and S. M. Nabavi. 2017. Flavonoids and platelet aggregation: A brief review. European Journal of Pharmacology an International Journal 807:91–101. doi: 10.1016/j.ejphar.2017.04.009.
   PubMed Web of Science ®Google Scholar
• Nambiar, D. K., G. Deep, R. P. Singh, C. Agarwal, and R. Agarwal. 2014. Abstract 2452: Silibinin inhibits lipid metabolism by primarily targeting the master regulator sterol response element binding protein 1 (SREBP1) in prostate cancer cells. Cancer Research 74 (19 Supplement):2452. doi: 10.1158/1538-7445.AM2014-2452.
   Web of Science ®Google Scholar
• Nichols, L. A., D. E. Jackson, J. A. Manthey, S. D. Shukla, and L. J. Holland. 2011. Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. Lipids in Health and Disease 10:36. doi: 10.1186/1476-511X-10-36.
   PubMedGoogle Scholar
• Odenwald, M. A., and J. R. Turner. 2016. The intestinal epithelial barrier: A therapeutic target? Nature Reviews Gastroenterology & Hepatology 14 (1):9. doi: 10.1038/nrgastro.2016.169.
   PubMed Web of Science ®Google Scholar
• Ohara, K., H. Wakabayashi, Y. Taniguchi, K. Shindo, H. Yajima, and A. Yoshida. 2013. Quercetin-3-O-glucuronide induces ABCA1 expression by LXRalpha activation in murine macrophages. Biochemical and Biophysical Research Communications 441 (4):929–34. doi: 10.1016/j.bbrc.2013.10.168.
   PubMed Web of Science ®Google Scholar
• Ohtsuki, K., A. Abe, H. Mitsuzumi, M. Kondo, K. Uemura, Y. Iwasaki, K. Uemura, Y. Iwasaki, and Y. Kondo. 2003. Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature. Journal of Nutritional Science & Vitaminology 49 (6):447–50. doi: 10.3177/jnsv.49.447.
   PubMed Web of Science ®Google Scholar
• Orhan, I. E., S. F. Nabavi, M. Daglia, G. C. Tenore, K. Mansouri, and S. M. Nabavi. 2015. Naringenin and atherosclerosis: A review of Literature. Current Pharmaceutical Biotechnology 16 (3):245–51. doi: 10.2174/1389201015666141202110216.
   PubMed Web of Science ®Google Scholar
• Oteiza, P. I., C. G. Fraga, D. A. Mills, and D. H. Taft. 2018. Flavonoids and the gastrointestinal tract: Local and systemic effects. Molecular Aspects of Medicine 61:41–9. doi: 10.1016/j.mam.2018.01.001.
   PubMed Web of Science ®Google Scholar
• Pala, R., V. T. Anju, M. Dyavaiah, S. Busi, and S. M. Nauli. 2020. Nanoparticle-mediated drug delivery for the treatment of cardiovascular diseases. International Journal of Nanomedicine 15:3741–69. doi: 10.2147/IJN.S250872.
   PubMed Web of Science ®Google Scholar
• Panche, A. N., A. D. Diwan, and S. R. Chandra. 2016. Flavonoids: An overview. Journal of Nutritional Science 5:e47. doi: 10.1017/jns.2016.41.
   PubMed Web of Science ®Google Scholar
• Passamonti, S., M. Terdoslavich, R. Franca, A. Vanzo, F. Tramer, E. Braidot, E. Petrussa, and A. Vianello. 2009. Bioavailability of flavonoids: A review of their membrane transport and the function of bilitranslocase in animal and plant organisms. Current Drug Metabolism 10 (4):369–94. doi: 10.2174/138920009788498950.
   PubMed Web of Science ®Google Scholar
• Roza, J., M. Zheng, G. Xian-Liu, and N. Guthrie. 2007. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Alternative Therapies in Health & Medicine 13 (6):44–8. doi: 10.1016/j.phymed.2007.06.011.
   PubMed Web of Science ®Google Scholar
• Sesink, A. L., I. C. Arts, V. C. de Boer, P. Breedveld, J. H. Schellens, P. C. Hollman, F. G. M. Russel. 2005. Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides. Molecular Pharmacology 67 (6):1999–2006. doi: 10.1124/mol.104.009753.
   PubMed Web of Science ®Google Scholar
• Shin, Y. W., S. H. Bok, T. S. Jeong, K. H. Bae, N. H. Jeoung, M. S. Choi, S. H. Lee, and Y. B. Park. 1999. Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. International Journal for Vitamin and Nutrition Research 69 (5):341–7. doi: 10.1024/0300-9831.69.5.341.
   PubMed Web of Science ®Google Scholar
• Song, X.-L., J. Bao, Z.-N. Zhang, J.-S. Zhang, X.-L. Song, W. Zhang, J. Bao, W.-W. Li, and D.-F. Cai. 2016. PI3K/Akt pathway contributes to neuroprotective effect of Tongxinluo against focal cerebral ischemia and reperfusion injury in rats. Journal of Ethnopharmacology An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs 181:8–19. doi: 10.1016/j.jep.2016.01.028.
   Google Scholar
• Stevens, Y., E. V. Rymenant, C. Grootaert, J. V. Camp, S. Possemiers, A. Masclee, and D. Jonkers. 2019. The intestinal fate of citrus flavanones and their effects on gastrointestinal health. Nutrients 11 (7):1464. doi: 10.3390/nu1107.
   Web of Science ®Google Scholar
• Taher, M., N. Shukry, D. Susanti, M. Wan, and Y. Syukri. 2020. Citrus flavonoids in preventing cardiovascular diseases. In Plant-derived bioactives, ed. M. Swamy, 495–508. Singapore: Springer. doi: 10.1007/978-981-15-2361-8_22.
   Google Scholar
• Taiming, L., and J. Xuehua. 2006. Investigation of the absorption mechanisms of baicalin and baicalein in rats. Comparative Study 95 (6):1326–33. doi: 10.1002/jps.20593.
   Google Scholar
• Tammela, P. I., L. Laitinen, A. Galkin, T. Wennberg, R. Heczko, H. Vuorela, J. P. Slotte, and P. Vuorela. 2004. Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Archives of Biochemistry & Biophysics 425 (2):199. doi: 10.1016/j.abb.2004.03.023.
   Web of Science ®Google Scholar
• Testai, L., and V. Calderone. 2017. Nutraceutical value of citrus flavanones and their Implications in cardiovascular disease. Nutrients 9 (5):502. doi: 10.3390/nu9050502.
   PubMed Web of Science ®Google Scholar
• Tripoli, E., M. L. Guardia, S. Giammanco, D. D. Majo, and M. Giammanco. 2007. Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food Chemistry 104 (2):466–79. doi: 10.1016/j.foodchem.2006.11.054.
   Web of Science ®Google Scholar
• Van der Woude, H., M. G. Boersma, J. Vervoort, and I. M. Rietjens. 2004. Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems. Chemical Research in Toxicology 17 (11):1520–30. doi: 10.1021/tx049826v.
   PubMed Web of Science ®Google Scholar
• Wang, Y., J. Cao, and S. Zeng. 2005. Involvement of p-glycoprotein in regulating cellular levels of ginkgo flavonols: Quercetin, kaempferol, and isorhamnetin. Journal of Pharmacy & Pharmacology 57 (6):751–8. doi: 10.1211/0022357056299.
   PubMed Web of Science ®Google Scholar
• Wang, Y., X. Liu, H. Shi, Y. Yu, and R. Chen. 2020. NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases. Clinical and Translational Medicine 10 (1):91–106. doi: 10.1002/ctm2.13.
   PubMed Web of Science ®Google Scholar
• Wang, P., M. Li, D. Wei, M. Ding, L. Tao, X. Liu, F. Zhang, N. Tao, X. Wang, M. Gao, et al. 2020. Electrosprayed soft capsules of millimeter size for specifically delivering fish oil/nutrients to the stomach and intestines. ACS Applied Materials & Interfaces 12 (5):6536–45. doi: 10.1021/acsami.9b23623.
   PubMed Web of Science ®Google Scholar
• Wen, X., and T. Walle. 2006. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metabolism and Disposition 34 (10):1786–92. doi: 10.1124/dmd.106.011122.
   PubMed Web of Science ®Google Scholar
• Whitman, S. C., E. M. Kurowska, J. A. Manthey, and A. Daugherty. 2005. Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. Atherosclerosis 178 (1):25–32. doi: 10.1016/j.atherosclerosis.2004.07.034.
   PubMed Web of Science ®Google Scholar
• Williamson, G., and M. N. Clifford. 2017. Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols. Biochemical Pharmacology 139:24–39. doi: 10.1016/j.bcp.2017.03.012.
   PubMed Web of Science ®Google Scholar
• Wójcicka, G., A. Jamroz-Winiewska, K. Horoszewicz, and J. Betowski. 2007. Liver X receptors (LXRs). Part I: Structure, function, regulation of activity, and role in lipid metabolism. Postȩpy Higieny I Medycyny Doświadczalnej 61:736–59.
   Google Scholar
• Wu, C. H., M. C. Lin, H. C. Wang, M. Y. Yang, M. J. Jou, and C. J. Wang. 2011. Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells. Journal of Food Science 76 (2):T65–T72. doi: 10.1111/j.1750-3841.2010.02033.x.
   PubMed Web of Science ®Google Scholar
• Wu, X., D. Zheng, Y. Qin, Z. Liu, G. Zhang, X. Zhu, L. Zeng, and Z. Liang. 2017. Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats via restoring autophagy flux. Biochemical and Biophysical Research Communications 492 (2):262–8. doi: 10.1016/j.bbrc.2017.08.064.
   PubMed Web of Science ®Google Scholar
• Yamada, T., S. Hayasaka, Y. Shibata, T. Ojima, T. Saegusa, T. Gotoh, S. Ishikawa, Y. Nakamura, and K. Kayaba. 2011. Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: The Jichi Medical School Cohort Study. Journal of Epidemiology 21 (3):169–75. doi: 10.2188/jea.JE20100084.
   PubMed Web of Science ®Google Scholar
• Yamamoto, M., H. Jokura, A. Suzuki, T. Hase, and A. Shimotoyodome. 2013. Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats. Journal of Nutritional Science and Vitaminology 59 (5):470–3. doi: 10.3177/jnsv.59.470.
   PubMed Web of Science ®Google Scholar
• Yamamoto, M., A. Suzuki, and T. Hase. 2008. Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. Journal of Nutritional Science and Vitaminology 54 (1):95–8. doi: 10.1016/j.vaccine.2003.10.022.
   PubMed Web of Science ®Google Scholar
• Yoshida, H., W. Watanabe, H. Oomagari, E. Tsuruta, M. Shida, and M. Kurokawa. 2013. Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes. Journal of Nutritional Biochemistry 24 (7):1276–84. doi: 10.1016/j.jnutbio.2012.10.003.
   PubMed Web of Science ®Google Scholar
• Yu, J., L. Wang, R. L. Walzem, E. G. Miller, L. M. Pike, and B. S. Patil. 2005. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. Journal of Agricultural and Food Chemistry 53 (6):2009–14. doi: 10.1021/jf0484632.
   PubMed Web of Science ®Google Scholar
• Yu, H., H. Zhang, W. Zhao, L. Guo, X. Li, Y. Li, X. Zhang, and Y. Sun. 2016. Gypenoside protects against myocardial ischemia-reperfusion injury by inhibiting cardiomyocytes apoptosis via inhibition of CHOP pathway and activation of PI3K/Akt pathway in vivo and in vitro. Cellular Physiology and Biochemistry 39 (1):123–36. doi: 10.1159/000445611.
   PubMedGoogle Scholar
• Zang, L., Y. Shimada, J. Kawajiri, T. Tanaka, and N. Nishimura. 2014. Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model. Journal of Functional Foods 10:499–510. doi: 10.1016/j.jff.2014.08.002.
   Web of Science ®Google Scholar
• Zhang, B. C., C. W. Zhang, C. Wang, D. F. Pan, and D. Y. Li. 2016. Luteolin attenuates foam cell formation and apoptosis in ox-LDL-stimulated macrophages by enhancing autophagy. Cellular Physiology and Biochemistry International Journal of Experimental 39 (5):2065–76. doi: 10.1016/j.jacc.2016.03.053.
   PubMedGoogle Scholar
• Zhu, J. N., R. Chen, Y. H. Fu, Q. X. Lin, S. Huang, L. L. Guo, M.-Z. Zhang, C.-Y. Deng, X. Zou, S.-L. Zhong, et al. 2013. Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat. PLoS ONE. 8 (9):e7555. doi: 10.1371/journal.pone.0075557.
   Web of Science ®Google Scholar