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Review Articles

Iron intake and multiple health outcomes: Umbrella review

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References

  • Abbaspour, N., R. Hurrell, and R. Kelishadi. 2014. Review on iron and its importance for human health. Journal of Research in Medical Sciences 19 (2):164–74.
  • Allen, L. H. 2001. Biological mechanisms that might underlie iron’s effects on fetal growth and preterm birth. The Journal of Nutrition 131 (2S-2):581S–9s. doi: 10.1093/jn/131.2.581S.
  • Anderson, R. A. 2003. Chromium and insulin resistance. Nutrition Research Reviews 16 (2):267–75. doi: 10.1079/nrr200366.
  • Anderson, G. J., and D. M. Frazer. 2017. Current understanding of iron homeostasis. The American Journal of Clinical Nutrition 106 (Suppl 6):1559s–66s. doi: 10.3945/ajcn.117.155804.
  • Andrews, N. C. 2008. Forging a field: The golden age of iron biology. Blood 112 (2):219–30. doi: 10.1182/blood-2007-12-077388.
  • Ani, M., and A. A. Moshtaghie. 1992. The effect of chromium on parameters related to iron metabolism. Biological Trace Element Research 32:57–64. doi: 10.1007/bf02784588.
  • Aromataris, E., R. Fernandez, C. M. Godfrey, C. Holly, H. Khalil, and P. Tungpunkom. 2015. Summarizing systematic reviews: Methodological development, conduct and reporting of an umbrella review approach. International Journal of Evidence-Based Healthcare 13 (3):132–40. doi: 10.1097/xeb.0000000000000055.
  • Backe, M. B., I. W. Moen, C. Ellervik, J. B. Hansen, and T. Mandrup-Poulsen. 2016. Iron regulation of pancreatic beta-cell functions and oxidative stress. Annual Review of Nutrition 36:241–73. doi: 10.1146/annurev-nutr-071715-050939.
  • Balder, H. F., J. Vogel, M. C. J. F. Jansen, M. P. Weijenberg, P. A. van den Brandt, S. Westenbrink, R. van der Meer, and R. A. Goldbohm. 2006. Heme and chlorophyll intake and risk of colorectal cancer in the Netherlands cohort study. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 15 (4):717–25. doi: 10.1158/1055-9965.Epi-05-0772.
  • Bao, W., Y. Rong, S. Rong, and L. Liu. 2012. Dietary iron intake, body iron stores, and the risk of type 2 diabetes: A systematic review and meta-analysis. BMC Medicine 10 (1):119. doi: 10.1186/1741-7015-10-119.
  • Bartzokis, G., T. A. Tishler, I. S. Shin, P. H. Lu, and J. L. Cummings. 2004. Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases. Annals of the New York Academy of Sciences 1012:224–36. doi: 10.1196/annals.1306.019.
  • Beard, J. L. 2008. Why iron deficiency is important in infant development. The Journal of Nutrition 138 (12):2534–6. doi: 10.1093/jn/138.12.2534.
  • Beard, J. L., J. R. Connor, and B. C. Jones. 1993. Iron in the brain. Nutrition Reviews 51 (6):157–70. doi: 10.1111/j.1753-4887.1993.tb03096.x.
  • Bezerra, I. N., J. Goldman, D. G. Rhodes, M. K. Hoy, A. d Moura Souza, D. N. Chester, C. L. Martin, R. S. Sebastian, J. K. Ahuja, R. Sichieri, et al. 2014. Difference in adult food group intake by sex and age groups comparing Brazil and United States nationwide surveys. Nutrition Journal 13:74. doi: 10.1186/1475-2891-13-74.
  • Bingham, S. A., R. Hughes, and A. J. Cross. 2002. Effect of white versus red meat on endogenous N-nitrosation in the human colon and further evidence of a dose response. The Journal of Nutrition 132 (11 Suppl):3522S–5s. doi: 10.1093/jn/132.11.3522S.
  • Bylsma, L. C., and D. D. Alexander. 2015. A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutrition Journal 14:125. doi: 10.1186/s12937-015-0111-3.
  • Cai, C., M. Granger, P. Eck, and J. Friel. 2017. Effect of daily iron supplementation in healthy exclusively breastfed infants: A systematic review with meta-analysis. Breastfeed Medicine 12 (10):597–603. doi: 10.1089/bfm.2017.0003.
  • Cao, H., C. Wang, R. Chai, Q. Dong, and S. Tu. 2017. Iron intake, serum iron indices and risk of colorectal adenomas: A meta-analysis of observational studies. European Journal of Cancer Care (Engl) 26 (5):e12486. doi: 10.1111/ecc.12486.
  • Carpenter, C. E., and A. W. Mahoney. 1992. Contributions of heme and nonheme iron to human nutrition. Critical Reviews in Food Science and Nutrition 31 (4):333–67. doi: 10.1080/10408399209527576.
  • Chang, V. C., M. Cotterchio, and E. Khoo. 2019. Iron intake, body iron status, and risk of breast cancer: A systematic review and meta-analysis. BMC Cancer 19 (1):543. doi: 10.1186/s12885-019-5642-0.
  • Chen, X., R. Kang, G. Kroemer, and D. Tang. 2021. Broadening horizons: The role of ferroptosis in cancer. Nature Reviews. Clinical Oncology 18 (5):280–96. doi: 10.1038/s41571-020-00462-0.
  • Cheng, P., J. Yu, W. Huang, S. Bai, X. Zhu, Z. Qi, W. Shao, and P. Xie. 2015. Dietary intake of iron, zinc, copper, and risk of Parkinson’s disease: A meta-analysis. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 36 (12):2269–75. doi: 10.1007/s10072-015-2349-0.
  • Cogswell, M. E., I. Parvanta, L. Ickes, R. Yip, and G. M. Brittenham. 2003. Iron supplementation during pregnancy, anemia, and birth weight: A randomized controlled trial. The American Journal of Clinical Nutrition 78 (4):773–81. doi: 10.1093/ajcn/78.4.773.
  • Cooksey, R. C., D. Jones, S. Gabrielsen, J. Huang, J. A. Simcox, B. Luo, Y. Soesanto, H. Rienhoff, E. D. Abel, and D. A. McClain. 2010. Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. American Journal of Physiology. Endocrinology and Metabolism 298 (6):E1236–1243. doi: 10.1152/ajpendo.00022.2010.
  • Cross, A. J., L. M. Ferrucci, A. Risch, B. I. Graubard, M. H. Ward, Y. Park, A. R. Hollenbeck, A. Schatzkin, and R. Sinha. 2010. A large prospective study of meat consumption and colorectal cancer risk: An investigation of potential mechanisms underlying this association. Cancer Research 70 (6):2406–14. doi: 10.1158/0008-5472.CAN-09-3929.
  • Cross, A. J., J. M. Harnly, L. M. Ferrucci, A. Risch, S. T. Mayne, and R. Sinha. 2012. Developing a heme iron database for meats according to meat type, cooking method and doneness level. Food and Nutrition Sciences 3 (7):905–13. doi: 10.4236/fns.2012.37120.
  • Cross, A. J., J. R. Pollock, and S. A. Bingham. 2003. Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat. Cancer Research 63 (10):2358–60.
  • Davoodi, S. H., Y. Jamshidinaeini, S. Esmaeili, S. Sohrabvandi, and A. M. Mortazavian. 2016. The dual nature of iron in relation to cancer: A review. Iranian Journal of Cancer Prevention 9 (6).
  • Dixon, S. J., K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, C. E. Gleason, D. N. Patel, A. J. Bauer, A. M. Cantley, W. S. Yang, et al. 2012. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell 149 (5):1060–72. doi: 10.1016/j.cell.2012.03.042.
  • Dos Santos Vieira, D. A., C. Hermes Sales, C. L. Galvão Cesar, D. M. Marchioni, and R. M. Fisberg. 2018. Influence of haem, non-haem, and total iron intake on metabolic syndrome and its components: A population-based study. Nutrients 10 (3):314. doi: 10.3390/nu10030314.
  • Egger, M., G. Davey Smith, M. Schneider, and C. Minder. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical Research ed.) 315 (7109):629–34. doi: 10.1136/bmj.315.7109.629.
  • Evans, J. L., I. D. Goldfine, B. A. Maddux, and G. M. Grodsky. 2002. Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocrine Reviews 23 (5):599–622. doi: 10.1210/er.2001-0039.
  • Facchini, F. S. 1998. Effect of phlebotomy on plasma glucose and insulin concentrations. Diabetes Care 21 (12):2190. doi: 10.2337/diacare.21.12.2190a.
  • Facchini, F. S., and K. L. Saylor. 2006. Effect of iron depletion on cardiovascular risk factors: Studies in carbohydrate-intolerant patients. Annals of the New York Academy of Sciences 967 (1):342–51. doi: 10.1111/j.1749-6632.2002.tb04290.x.
  • Fang, X., P. An, H. Wang, X. Wang, X. Shen, X. Li, J. Min, S. Liu, and F. Wang. 2015. Dietary intake of heme iron and risk of cardiovascular disease: A dose-response meta-analysis of prospective cohort studies. Nutrition Metabolism and Cardiovascular Diseases 25 (1):24–35. doi: 10.1016/j.numecd.2014.09.002.
  • Feder, J. N., A. Gnirke, W. Thomas, Z. Tsuchihashi, D. A. Ruddy, A. Basava, F. Dormishian, R. Domingo, M. C. Ellis, A. Fullan, et al. 1996. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genetics 13 (4):399–408. doi: 10.1038/ng0896-399.
  • Fernández-Real, J. M., and M. Manco. 2014. Effects of iron overload on chronic metabolic diseases. The Lancet. Diabetes & Endocrinology 2 (6):513–26. doi: 10.1016/S2213-8587(13)70174-8.
  • Fernández-Real, J. M., G. Peñarroja, A. Castro, F. García-Bragado, I. Hernández-Aguado, and W. Ricart. 2002. Blood letting in high-ferritin type 2 diabetes: Effects on insulin sensitivity and beta-cell function. Diabetes 51 (4):1000–4. doi: 10.2337/diabetes.51.4.1000.
  • Ferrucci, L. M., A. J. Cross, B. I. Graubard, L. A. Brinton, C. A. McCarty, R. G. Ziegler, X. Ma, S. T. Mayne, and R. Sinha. 2009. Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. British Journal of Cancer 101 (1):178–84. doi: 10.1038/sj.bjc.6605118.
  • Ficiarà, E., Z. Munir, S. Boschi, M. E. Caligiuri, and C. Guiot. 2021. Alteration of iron concentration in Alzheimer’s disease as a possible diagnostic biomarker unveiling ferroptosis. International Journal of Molecular Sciences 22 (9):4479. doi: 10.3390/ijms22094479.
  • Finch, C. A., L. R. Miller, A. R. Inamdar, R. Person, K. Seiler, and B. Mackler. 1976. Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. The Journal of Clinical Investigation 58 (2):447–53. doi: 10.1172/jci108489.
  • Fonseca-Nunes, A., P. Jakszyn, and A. Agudo. 2014. Iron and cancer risk-a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23 (1):12–31. doi: 10.1158/1055-9965.Epi-13-0733.
  • Förstermann, U., N. Xia, and H. Li. 2017. Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis. Circulation Research 120 (4):713–35. doi: 10.1161/circresaha.116.309326.
  • Fridlyand, L. E., and L. H. Philipson. 2004. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes 53 (8):1942–8. doi: 10.2337/diabetes.53.8.1942.
  • Gulec, S., G. J. Anderson, and J. F. Collins. 2014. Mechanistic and regulatory aspects of intestinal iron absorption. American Journal of Physiology. Gastrointestinal and Liver Physiology 307 (4):G397–409. doi: 10.1152/ajpgi.00348.2013.
  • Guyatt, G., A. D. Oxman, E. A. Akl, R. Kunz, G. Vist, J. Brozek, S. Norris, Y. Falck-Ytter, P. Glasziou, H. DeBeer, et al. 2011. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. Journal of Clinical Epidemiology 64 (4):383–94. doi: 10.1016/j.jclinepi.2010.04.026.
  • Haas, J. D., and T. t. Brownlie. 2001. Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship. The Journal of Nutrition 131 (2S-2):676S–88S. discussion 688S-690S. doi: 10.1093/jn/131.2.676S.
  • Haider, B. A., I. Olofin, M. Wang, D. Spiegelman, M. Ezzati, and W. W. Fawzi, on behalf of Nutrition Impact Model Study Group (anaemia). 2013. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: Systematic review and meta-analysis. BMJ 346 (jun21 3):f3443. doi: 10.1136/bmj.f3443.
  • Han, M., L. Guan, Y. Ren, Y. Zhao, D. Liu, D. Zhang, L. Liu, F. Liu, X. Chen, C. Cheng, et al. 2020. Dietary iron intake and risk of death due to cardiovascular diseases: A systematic review and dose-response meta-analysis of prospective cohort studies. Asia Pacific Journal of Clinical Nutrition 29 (2):309–21. doi: 10.6133/apjcn.202007_29(2).0014
  • Hansen, J. B., I. W. Moen, and T. Mandrup-Poulsen. 2014. Iron: The hard player in diabetes pathophysiology. Acta Physiologica (Oxford, England) 210 (4):717–32. doi: 10.1111/apha.12256.
  • Hu, X., X. Cai, R. Ma, W. Fu, C. Zhang, and X. Du. 2019. Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages. Journal of Cellular Physiology 234 (10):18792–800. doi: 10.1002/jcp.28518.
  • Huang, X. 2003. Iron overload and its association with cancer risk in humans: Evidence for iron as a carcinogenic metal. Mutation Research 533 (1-2):153–71. doi: 10.1016/j.mrfmmm.2003.08.023.
  • Huang, Y., D. Cao, Z. Chen, B. Chen, J. Li, J. Guo, Q. Dong, L. Liu, and Q. Wei. 2021. Red and processed meat consumption and cancer outcomes: Umbrella review. Food Chemistry 356:129697. doi: 10.1016/j.foodchem.2021.129697.
  • Huang, J., D. Jones, B. Luo, M. Sanderson, J. Soto, E. D. Abel, R. C. Cooksey, and D. A. McClain. 2011. Iron overload and diabetes risk: A shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes 60 (1):80–7. doi: 10.2337/db10-0593.
  • Hunnicutt, J., K. He, and P. Xun. 2014. Dietary iron intake and body iron stores are associated with risk of coronary heart disease in a meta-analysis of prospective cohort studies. The Journal of Nutrition 144 (3):359–366. doi: 10.3945/jn.113.185124.
  • Hurrell, R., and I. Egli. 2010. Iron bioavailability and dietary reference values. The American Journal of Clinical Nutrition 91 (5):1461S–1467s. doi: 10.3945/ajcn.2010.28674F.
  • Iannotti, L. L., J. M. Tielsch, M. M. Black, and R. E. Black. 2006. Iron supplementation in early childhood: Health benefits and risks. The American Journal of Clinical Nutrition 84 (6):1261–1276. doi: 10.1093/ajcn/84.6.1261.
  • Imdad, A., and Z. A. Bhutta. 2012. Routine iron/folate supplementation during pregnancy: Effect on maternal anaemia and birth outcomes. Paediatric and Perinatal Epidemiology 26 (Suppl 1):168–177. Retrieved from https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=365132124 2274. https://sfx-86scu.hosted.exlibrisgroup.com.cn/86scu?sid=OVID:embase&id=pmid2609&id=doi:10.1111%2Fj.1365-3016.2012.01312.x&issn=02695022&isbn=&volume=26&issue=SUPPL.+1&spage=68&pages=168-177&date=2012&title=Paediatric+and+Perinatal+Epidemiology&atitle=Routine+iron%2Ffolate+supplementation+during+pre009;birth+outcomes&aulast=Imdad&pid=%3Cauthor%3EImdad+A.%3BBhutta+Z.A.% 3C%2Fauthor%3E%3CAN%3E365132124%3C%2FAN%3E%3CDT%3EArticle%3C%2FDT%3E.
  • Inoue-Choi, M., R. Sinha, G. L. Gierach, and M. H. Ward. 2016. Red and processed meat, nitrite, and heme iron intakes and postmenopausal breast cancer risk in the NIH-AARP Diet and Health Study. International Journal of Cancer 138 (7):1609–1618. doi: 10.1002/ijc.29901.
  • Institute of Medicine. 2001. Dietary reference intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US). Copyright 2001. by the National Academy of Sciences. All rights reserved.
  • Ioannidis, J. P. 2009. Integration of evidence from multiple meta-analyses: A primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. CMAJ: Canadian Medical Association Journal = Journal de L’Association Medicale Canadienne 181 (8):488–493. doi: 10.1503/cmaj.081086.
  • Ioannidis, J. P. 2016. The mass production of redundant, misleading, and conflicted systematic reviews and meta-analyses. The Milbank Quarterly 94 (3):485–514. doi: 10.1111/1468-0009.12210.
  • Ioannidis, J. P., and T. A. Trikalinos. 2007. An exploratory test for an excess of significant findings. Clinical Trials (London, England) 4 (3):245–253. doi: 10.1177/1740774507079441.
  • Jacobs, D. R., Jr., L. Marquart, J. Slavin, and L. H. Kushi. 1998. Whole-grain intake and cancer: An expanded review and meta-analysis. Nutrition and Cancer 30 (2):85–96. doi: 10.1080/01635589809514647.
  • Jakszyn, P., A. Agudo, L. Lujan-Barroso, H. B. Bueno-de-Mesquita, M. Jenab, C. Navarro, D. Palli, H. Boeing, J. Manjer, M. E. Numans, et al. 2012. Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. International Journal of Cancer 130 (11):2654–2663. doi: 10.1002/ijc.26263.
  • Jayasinghe, C., R. Polson, H. C. van Woerden, and P. Wilson. 2018. The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring: A systematic review and meta-analysis. BMC Pediatrics 18 (1):150. doi: 10.1186/s12887-018-1118-7.
  • Kataria, Y., Y. Wu, P. d. H. Horskjaer, T. Mandrup-Poulsen, and C. Ellervik. 2018. Iron status and gestational diabetes-a meta-analysis. Nutrients 10 (5):621. Retrieved from https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed19&AN=622126912https://sfx-86scu.hosted.exlibrisgroup.com.cn/86scu?sid=OVID:embase&id=pmid:29762515&id=doi:10.3390%2Fnu10050621&issn=20726643&isbn=&volume=10&issue=5&spage=621&pages=&date=2018&title=Nutrients&atitle=Iron+status+and+gestational+diabetes-a+meta-analysis&aulast=Kataria&pid=%3Cauthor%3EKataria+Y.%3BWu+Y.%3BHorskjaer+P.H.%3BMandrup-Poulsen+T.%3BEllervik+C.%3C%2Fauthor%3E%3CAN%3E622126912%3C%2FAN%3E%3CDT%3EReview%3C%2FDT%3E.
  • Kawada, S., Y. Nagasawa, M. Kawabe, H. Ohyama, A. Kida, N. Kato-Kogoe, M. Nanami, Y. Hasuike, T. Kuragano, H. Kishimoto, et al. 2018. Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha. Scientific Reports 8 (1):658. doi: 10.1038/s41598-017-19092-1.
  • Landis, J. R., and G. G. Koch. 1977. The measurement of observer agreement for categorical data. Biometrics 33 (1):159–174.
  • Lang, X., M. D. Green, W. Wang, J. Yu, J. E. Choi, L. Jiang, P. Liao, J. Zhou, Q. Zhang, A. Dow, et al. 2019. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discovery 9 (12):1673–1685. doi: 10.1158/2159-8290.Cd-19-0338.
  • Langkammer, C., S. Ropele, L. Pirpamer, F. Fazekas, and R. Schmidt. 2014. MRI for iron mapping in Alzheimer’s disease. Neuro-Degenerative Diseases 13 (2–3):189–191. doi: 10.1159/000353756.
  • Li, R., X. Chen, H. Yan, P. Deurenberg, L. Garby, and J. G. Hautvast. 1994. Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China. The American Journal of Clinical Nutrition 59 (4):908–913. doi: 10.1093/ajcn/59.4.908.
  • Li, Z., B. Li, X. Song, and D. Zhang. 2017. Dietary zinc and iron intake and risk of depression: A meta-analysis. Psychiatry Research 251:41–47. doi: 10.1016/j.psychres.2017.02.006.
  • Lim, K. H., L. J. Riddell, C. A. Nowson, A. O. Booth, and E. A. Szymlek-Gay. 2013. Iron and zinc nutrition in the economically-developed world: A review. Nutrients 5 (8):3184–3211. doi: 10.3390/nu5083184.
  • Li, N., X. Wu, W. Zhuang, L. Xia, Y. Chen, C. Wu, Z. Rao, L. Du, R. Zhao, M. Yi, et al. 2020. Fish consumption and multiple health outcomes: Umbrella review. Trends in Food Science & Technology 99:273–283. doi: 10.1016/j.tifs.2020.02.033.
  • Low, M., A. Farrell, B. A. Biggs, and S. R. Pasricha. 2013. Effects of daily iron supplementation in primary-school-aged children: Systematic review and meta-analysis of randomized controlled trials. CMAJ: Canadian Medical Association Journal = Journal de L’Association Medicale Canadienne 185 (17):E791–802. doi: 10.1503/cmaj.130628.
  • Ma, J., Q. Li, X. Fang, L. Chen, Y. Qiang, J. Wang, Q. Wang, J. Min, S. Zhang, and F. Wang. 2018. Increased total iron and zinc intake and lower heme iron intake reduce the risk of esophageal cancer: A dose-response meta-analysis. Nutrition Research (New York, N.Y.) 59:16–28. doi: 10.1016/j.nutres.2018.07.007.
  • McLean, E., M. Cogswell, I. Egli, D. Wojdyla, and B. de Benoist. 2009. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutrition 12 (4):444–454. doi: 10.1017/s1368980008002401.
  • Meng, Y., J. Sun, J. Yu, C. Wang, and J. Su. 2019. Dietary intakes of calcium, iron, magnesium, and potassium elements and the risk of colorectal cancer: A meta-analysis. Biological Trace Element Research 189 (2):325–335. doi: 10.1007/s12011-018-1474-z.
  • Mirvish, S. S. 1995. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Letters 93 (1):17–48. doi: 10.1016/0304-3835(95)03786-V.
  • Papatheodorou, S. 2019. Umbrella reviews: What they are and why we need them. European Journal of Epidemiology 34 (6):543–546. doi: 10.1007/s10654-019-00505-6.
  • Pasricha, S. R., E. Hayes, K. Kalumba, and B. A. Biggs. 2013. Effect of daily iron supplementation on health in children aged 4-23 months: A systematic review and meta-analysis of randomised controlled trials. The Lancet. Global Health 1 (2):e77–e86. doi: 10.1016/S2214-109X(13)70046-9.
  • Pasricha, S. R., M. Low, J. Thompson, A. Farrell, and L. M. De-Regil. 2014. Iron supplementation benefits physical performance in women of reproductive age: A systematic review and meta-analysis. The Journal of Nutrition 144 (6):906–914. doi: 10.3945/jn.113.189589.
  • Peña-Rosas, J. P., L. M. De-Regil, T. Dowswell, and F. E. Viteri. 2012. Daily oral iron supplementation during pregnancy. The Cochrane Database of Systematic Reviews 12:CD004736. doi: 10.1002/14651858.CD004736.pub4
  • Pollak, Y., D. Mechlovich, T. Amit, O. Bar-Am, I. Manov, S. A. Mandel, O. Weinreb, E. G. Meyron-Holtz, T. C. Iancu, and M. B. H. Youdim. 2013. Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism. Journal of Neural Transmission (Vienna, Austria: 1996) 120 (1):37–48. doi: 10.1007/s00702-012-0795-x.
  • Poole, R., O. J. Kennedy, P. Roderick, J. A. Fallowfield, P. C. Hayes, and J. Parkes. 2017. Coffee consumption and health: Umbrella review of meta-analyses of multiple health outcomes. BMJ (Clinical Research ed.) 359:j5024. doi: 10.1136/bmj.j5024.
  • Qiao, L., and Y. Feng. 2013. Intakes of heme iron and zinc and colorectal cancer incidence: A meta-analysis of prospective studies. Cancer Causes Control 24 (6):1175–1183. doi: 10.1007/s10552-013-0197-x.
  • Shamseer, L., D. Moher, M. Clarke, D. Ghersi, A. Liberati, M. Petticrew, P. Shekelle, and L. A. Stewart, PRISMA-P Group. 2015. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation. BMJ (Clinical Research ed.) 350:g7647. doi: 10.1136/bmj.g7647.
  • Shea, B. J., J. M. Grimshaw, G. A. Wells, M. Boers, N. Andersson, C. Hamel, A. C. Porter, P. Tugwell, D. Moher, and L. M. Bouter. 2007. Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews. BMC Medical Research Methodology 7:10. doi: 10.1186/1471-2288-7-10.
  • SIGN. 2020. Scottish intercollegiate guidelines network search filters. Retrieved from https://www.sign.ac.uk/what-we-do/methodology/search-filters/
  • Sivitskaya, L., N. Danilenko, Z. Zabarouskaya, and O. Davydenko. 2013. HFE gene mutation associated with the severity of gestational diabetes mellitus in Belarusian women. Open Journal of Endocrine and Metabolic Diseases 3 (1):13–17. doi: 10.4236/ojemd.2013.31002.
  • Suedekum, N. A., and R. J. Dimeff. 2005. Iron and the athlete. Current Sports Medicine Reports 4 (4):199–202. doi: 10.1097/01.csmr.0000306207.79809.7f.
  • Tasevska, N., R. Sinha, V. Kipnis, A. F. Subar, M. F. Leitzmann, A. R. Hollenbeck, N. E. Caporaso, A. Schatzkin, and A. J. Cross. 2009. A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks. The American Journal of Clinical Nutrition 89 (6):1884–1894. doi: 10.3945/ajcn.2008.27272.
  • Theodoratou, E., I. Tzoulaki, L. Zgaga, and J. P. Ioannidis. 2014. Vitamin D and multiple health outcomes: Umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ (Clinical Research ed.) 348:g2035. doi: 10.1136/bmj.g2035.
  • Torti, S. V., D. H. Manz, B. T. Paul, N. Blanchette-Farra, and F. M. Torti. 2018. Iron and Cancer. Annual Review of Nutrition 38:97–125. doi: 10.1146/annurev-nutr-082117-051732.
  • Tsoi, J., L. Robert, K. Paraiso, C. Galvan, K. M. Sheu, J. Lay, D. J. L. Wong, M. Atefi, R. Shirazi, X. Wang, et al. 2018. Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress. Cancer Cell 33 (5):890–904. doi: 10.1016/j.ccell.2018.03.017.
  • van Swelm, R. P. L., J. F. M. Wetzels, and D. W. Swinkels. 2020. The multifaceted role of iron in renal health and disease. Nature Reviews. Nephrology 16 (2):77–98. doi: 10.1038/s41581-019-0197-5.
  • Veronese, N., M. Solmi, M. G. Caruso, G. Giannelli, A. R. Osella, E. Evangelou, S. Maggi, L. Fontana, B. Stubbs, and I. Tzoulaki. 2018. Dietary fiber and health outcomes: An umbrella review of systematic reviews and meta-analyses. The American Journal of Clinical Nutrition 107 (3):436–444. doi: 10.1093/ajcn/nqx082.
  • Vinchi, F., M. U. Muckenthaler, M. C. Da Silva, G. Balla, J. Balla, and V. Jeney. 2014. Atherogenesis and iron: From epidemiology to cellular level. Frontiers in Pharmacology 5:94. doi: 10.3389/fphar.2014.00094.
  • Vinchi, F., G. Porto, A. Simmelbauer, S. Altamura, S. T. Passos, M. Garbowski, A. M. N. Silva, S. Spaich, S. E. Seide, R. Sparla, et al. 2020. Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. European Heart Journal 41 (28):2681–2695. doi: 10.1093/eurheartj/ehz112.
  • Viswanathan, V. S., M. J. Ryan, H. D. Dhruv, S. Gill, O. M. Eichhoff, B. Seashore-Ludlow, S. D. Kaffenberger, J. K. Eaton, K. Shimada, A. J. Aguirre, et al. 2017. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547 (7664):453–457. doi: 10.1038/nature23007.
  • Wallace, T. C., R. L. Bailey, J. B. Blumberg, B. Burton-Freeman, C.-Y O. Chen, K. M. Crowe-White, A. Drewnowski, S. Hooshmand, E. Johnson, R. Lewis, et al. 2020. Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake. Critical Reviews in Food Science and Nutrition 60 (13):2174–2211. doi: 10.1080/10408398.2019.1632258.
  • Wang, W., M. Green, J. E. Choi, M. Gijón, P. D. Kennedy, J. K. Johnson, P. Liao, X. Lang, I. Kryczek, A. Sell, et al. 2019. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569 (7755):270–274. doi: 10.1038/s41586-019-1170-y.
  • WCRF. 2018. Diet, nutrition, physical activity and cancer: A global perspective: A summary of the Third Expert Report. Retrieved from https://www.wcrf.org/dietandcancer/a-summary-of-the-third-expert-report/
  • Wolgemuth, J. C., M. C. Latham, A. Hall, A. Chesher, and D. W. Crompton. 1982. Worker productivity and the nutritional status of Kenyan road construction laborers. The American Journal of Clinical Nutrition 36 (1):68–78. doi: 10.1093/ajcn/36.1.68.
  • World Health Organization. 2021. Daily iron and folic acid supplementation during pregnancy. Retrieved from https://www.who.int/elena/titles/guidance_summaries/daily_iron_pregnancy/en/
  • Worwood, M. 2005. Inherited iron loading: Genetic testing in diagnosis and management. Blood Reviews 19 (2):69–88. doi: 10.1016/j.blre.2004.03.003.
  • Xu, S. 2019. Iron and atherosclerosis: The link revisited. Trends in Molecular Medicine 25 (8):659–661. doi: 10.1016/j.molmed.2019.05.012.
  • Xu, S., Y. He, L. Lin, P. Chen, M. Chen, and S. Zhang. 2021. The emerging role of ferroptosis in intestinal disease. Cell Death & Disease 12 (4):289. doi: 10.1038/s41419-021-03559-1.
  • Yang, W., B. Li, X. Dong, X.-Q. Zhang, Y. Zeng, J.-L. Zhou, Y.-H. Tang, and J.-J. Xu. 2014. Is heme iron intake associated with risk of coronary heart disease? A meta-analysis of prospective studies. European Journal of Nutrition 53 (2):395–400. doi: 10.1007/s00394-013-0535-5.
  • Yuan, X. M., and W. Li. 2008. Iron involvement in multiple signaling pathways of atherosclerosis: A revisited hypothesis. Current Medicinal Chemistry 15 (21):2157–2172. doi: 10.2174/092986708785747634.
  • Zein, S., S. Rachidi, and I. Hininger-Favier. 2014. Is oxidative stress induced by iron status associated with gestational diabetes mellitus? Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements (GMS) 28 (1):65–69. doi: 10.1016/j.jtemb.2013.09.009.
  • Zhao, Z., S. Li, G. Liu, F. Yan, X. Ma, Z. Huang, and H. Tian. 2012. Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: A systematic review and meta-analysis. PLoS One 7 (7):e41641. doi: 10.1371/journal.pone.0041641.
  • Zhu, H.-C., X. Yang, L.-P. Xu, L.-J. Zhao, G.-Z. Tao, C. Zhang, Q. Qin, J. Cai, J.-X. Ma, W.-D. Mao, et al. 2014. Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner. Digestive Diseases and Sciences 59 (3):664–673. doi: 10.1007/s10620-013-2928-y.
  • Zimmermann, M. B., and R. F. Hurrell. 2007. Nutritional iron deficiency. The Lancet 370 (9586):511–520. doi: 10.1016/S0140-6736(07)61235-5.

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