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Review Articles

Advances in the regulation of natural polysaccharides on human health: The role of apoptosis/autophagy pathway

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References

  • Asl, E. R., M. Amini, S. Najafi, B. Mansoori, A. Mokhtarzadeh, A. Mohammadi, P. Lotfinejad, M. Bagheri, S. Shirjang, Z. Lotfi, et al. 2021. Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression. Life Sciences 278:119499. doi: 10.1016/j.lfs.2021.119499.
  • Baghery Saghchy Khorasani, A., A. Pourbagheri-Sigaroodi, A. Pirsalehi, A. Safaroghli-Azar, M. R. Zali, and D. Bashash. 2021. The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for pharmacologic interventions. European Journal of Pharmacology 898:173983. doi: 10.1016/j.ejphar.2021.173983.
  • Barbosa, J. R., and R. N. de Carvalho Junior. 2021. Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19. Trends in Food Science and Technology 108:223–35. doi: 10.1016/j.tifs.2020.12.026.
  • Bie, N., L. Han, Y. Wang, X. Wang, and C. Wang. 2020. A polysaccharide from Grifola frondosa fruit body induces HT-29 cells apoptosis by PI3K/AKT-MAPKs and NF-κB-pathway . International Journal of Biological Macromolecules 147:79–88. doi: 10.1016/j.ijbiomac.2020.01.062.
  • Boice, A., and L. Bouchier-Hayes. 2020. Targeting apoptotic caspases in cancer. Biochimica et Biophysica Acta - Molecular Cell Research 1867 (6):118688. doi: 10.1016/j.bbamcr.2020.118688.
  • Bu, H. M., S. R. Tan, B. Yuan, X. M. Huang, J. B. Jiang, Y. J. Wu, J. H. Jiang, and R. P. Li. 2021. Therapeutic potential of IBP as an autophagy inducer for treating lung cancer via blocking PAK1/Akt/mTOR signaling. Molecular Therapy—Oncolytics 20:82–93. doi: 10.1016/j.omto.2020.10.014.
  • Burke, P. J. 2017. Mitochondria, bioenergetics and apoptosis in cancer. Trends in Cancer 3 (12):857–70. doi: 10.1016/j.trecan.2017.10.006.
  • Canbay, A., S. Friedman, and G. J. Gores. 2004. Apoptosis: The nexus of liver injury and fibrosis. Hepatology (Baltimore, MD) 39 (2):273–8. doi: 10.1002/hep.20051.
  • Cao, W., X. Q. Li, X. Wang, H. T. Fan, X. N. Zhang, Y. Hou, S. B. Liu, and Q. B. Mei. 2010. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 17 (8–9):598–605. doi: 10.1016/j.phymed.2009.12.014.
  • Cao, P., J. Sun, M. A. Sullivan, X. Huang, H. Wang, Y. Zhang, N. Wang, and K. Wang. 2018. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International Journal of Biological Macromolecules 111:1133–9. doi: 10.1016/j.ijbiomac.2018.01.139.
  • Chaabane, W., S. D. User, M. El-Gazzah, R. Jaksik, E. Sajjadi, J. Rzeszowska-Wolny, and M. J. Los. 2013. Autophagy, apoptosis, mitoptosis and necrosis: Interdependence between those pathways and effects on cancer. Archivum Immunologiae et Therapiae Experimentalis 61 (1):43–58. doi: 10.1007/s00005-012-0205-y.
  • Cheng, J., D. Liu, L. Zhao, Q. Zhao, X. Zhang, B. Wang, and D. Bai. 2021. Potentilla anserine L. polysaccharide inhibits cadmium-induced neurotoxicity by attenuating autophagy. Neurochemistry International 147:105045. doi: 10.1016/j.neuint.2021.105045.
  • Cheng, D., X. Zhang, M. Meng, L. Han, C. Li, L. Hou, W. Qi, and C. Wang. 2016. Inhibitory effect on HT-29 colon cancer cells of a water-soluble polysaccharide obtained from highland barley. International Journal of Biological Macromolecules 92:88–95. doi: 10.1016/j.ijbiomac.2016.06.099.
  • Chen, S., J. Wang, Q. Fang, N. Dong, Q. Fang, S. W. Cui, and S. Nie. 2021. A polysaccharide from natural Cordyceps sinensis regulates the intestinal immunity and gut microbiota in mice with cyclophosphamide-induced intestinal injury. Food & Function 12 (14):6271–82. doi: 10.1039/d1fo00596k.
  • Chen, D. D., R. Xu, J. Y. Zhou, J. Q. Chen, L. Wang, X. S. Liu, C. L. Liang, B. H. Liu, R. R. Lu, J. B. Wu, et al. 2019. Cordyceps militaris polysaccharides exerted protective effects on diabetic nephropathy in mice via regulation of autophagy. Food & Function 10 (8):5102–14. doi: 10.1039/c9fo00957d.
  • Chen, C., L. J. You, A. M. Abbasi, X. Fu, R. H. Liu, and C. Li. 2016. Characterization of polysaccharide fractions in mulberry fruit and assessment of their antioxidant and hypoglycemic activities in vitro. Food & Function 7 (1):530–9. doi: 10.1039/c5fo01114k.
  • Chiang, Y.-Y., and J. C. J. Chao. 2018. Olive oil combined with Lycium barbarum polysaccharides attenuates liver apoptosis and inflammation induced by carbon tetrachloride in rats. Journal of Functional Foods 48:329–36. doi: 10.1016/j.jff.2018.07.029.
  • Choi, J. W., J. Lee, S. C. Kim, S. You, C. W. Lee, J. Shin, and Y. I. Park. 2019. Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death. International Journal of Biological Macromolecules 124:1060–8. doi: 10.1016/j.ijbiomac.2018.12.001.
  • Cosentino, K., and A. J. Garcia-Saez. 2014. Mitochondrial alterations in apoptosis. Chemistry and Physics of Lipids 181:62–75. doi: 10.1016/j.chemphyslip.2014.04.001.
  • Cui, H., C. Wang, Y. Wang, Z. Li, Y. Zhang, M. Chen, and F. Li. 2014. Pleurotus nebrodensis polysaccharide induces apoptosis in human non-small cell lung cancer A549 cells. Carbohydrate Polymers 104:246–52. doi: 10.1016/j.carbpol.2014.01.001.
  • De Silva, D. D., S. Rapior, F. Fons, A. H. Bahkali, and K. D. Hyde. 2012. Medicinal mushrooms in supportive cancer therapies: An approach to anti-cancer effects and putative mechanisms of action. Fungal Diversity 55 (1):1–35. doi: 10.1007/s13225-012-0151-3.
  • Degenhardt, K., R. Mathew, B. Beaudoin, K. Bray, D. Anderson, G. Chen, C. Mukherjee, Y. Shi, C. Gelinas, Y. Fan, et al. 2006. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10 (1):51–64. doi: 10.1016/j.ccr.2006.06.001.
  • Demirtas, L., A. Guclu, F. M. Erdur, E. M. Akbas, A. Ozcicek, D. Onk, and K. Turkmen. 2016. Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus. The Indian Journal of Medical Research 144 (4):515–24. doi: 10.4103/0971-5916.200887.
  • Donepudi, M., and M. G. Grutter. 2002. Structure and zymogen activation of caspases. Biophysical Chemistry 101–102:145–53. doi: 10.1016/S0301-4622(02)00151-5.
  • Elmore, S. 2007. Apoptosis: A review of programmed cell death. Toxicologic Pathology 35 (4):495–516. doi: 10.1080/01926230701320337.
  • Fernandez-Garcia, J., P. Altea-Manzano, E. Pranzini, and S. M. Fendt. 2020. Stable isotopes for tracing mammalian-cell metabolism in vivo. Trends in Biochemical Sciences 45 (3):185–201. doi: 10.1016/j.tibs.2019.12.002.
  • Francis, G. 2001. Diabetic cardiomyopathy: Fact or fiction? Heart (British Cardiac Society) 85 (3):247–8. doi: 10.1136/heart.85.3.247.
  • Gan, D., X. Zeng, R. H. Liu, and H. Ye. 2015. Potential mechanism of mycelium polysaccharide from Pholiota dinghuensis Bi in regulating the proliferation and apoptosis of human breast cancer MCF-7 cells through p38/MAPK pathway. Journal of Functional Foods 12:375–88. doi: 10.1016/j.jff.2014.12.008.
  • Gong, G., Q. Liu, Y. Deng, T. Dang, W. Dai, T. Liu, Y. Liu, J. Sun, L. Wang, Y. Liu, et al. 2020. Arabinogalactan derived from Lycium barbarum fruit inhibits cancer cell growth via cell cycle arrest and apoptosis. International Journal of Biological Macromolecules 149:639–50. doi: 10.1016/j.ijbiomac.2020.01.251.
  • Guicciardi, M. E., and G. J. Gores. 2005. Apoptosis: A mechanism of acute and chronic liver injury. Gut 54 (7):1024–33. doi: 10.1136/gut.2004.053850.
  • Guo, J., J. Wang, S. Song, Q. Liu, Y. Huang, Y. Xu, Y. Wei, and J. Zhang. 2016. Sphallerocarpus gracilis polysaccharide protects pancreatic β-cells via regulation of the bax/bcl-2, caspase-3, pdx-1 and insulin signalling pathways. International Journal of Biological Macromolecules 93 (Pt A):829–36. doi: 10.1016/j.ijbiomac.2016.08.083.
  • Hanyu, X., L. Lanyue, D. Miao, F. Wentao, C. Cangran, and S. Hui. 2020. Effect of Ganoderma applanatum polysaccharides on MAPK/ERK pathway affecting autophagy in breast cancer MCF-7 cells. International Journal of Biological Macromolecules 146:353–62. doi: 10.1016/j.ijbiomac.2020.01.010.
  • Ho Do, M., Y. S. Seo, and H.-Y. Park. 2021. Polysaccharides: Bowel health and gut microbiota. Critical Reviews in Food Science and Nutrition 61 (7):1212–24. doi: 10.1080/10408398.2020.1755949.
  • Hou, K., Q. Yu, X. Hu, X. Ding, J. Hong, Y. Chen, J. Xie, S. Nie, and M. Xie. 2019. Protective effect of Ganoderma atrum polysaccharide on acrolein-induced macrophage injury via autophagy-dependent apoptosis pathway. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 133:110757. doi: 10.1016/j.fct.2019.110757.
  • Hu, C. A., Y. Hou, D. Yi, Y. Qiu, G. Wu, X. Kong, and Y. Yin. 2015. Autophagy and tight junction proteins in the intestine and intestinal diseases. Animal Nutrition 1 (3):123–7. doi: 10.1016/j.aninu.2015.08.014.
  • Hu, X., Q. Yu, K. Hou, X. Ding, Y. Chen, J. Xie, S. Nie, and M. Xie. 2020. Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 140:111321. doi: 10.1016/j.fct.2020.111321.
  • Jiang, S., F. Shi, H. Lin, Y. Ying, L. Luo, D. Huang, and Z. Luo. 2020. Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis. International Journal of Biological Macromolecules 151:1277–86. doi: 10.1016/j.ijbiomac.2019.10.174.
  • Ke, Y., L. Zhan, T. Lu, C. Zhou, X. Chen, Y. Dong, G. Lv, and S. Chen. 2020. Polysaccharides of Dendrobium officinale Kimura & Migo leaves protect against ethanol-induced gastric mucosal injury via the AMPK/mTOR signaling pathway in vitro and vivo. Frontiers in Pharmacology 11:526349. doi: 10.3389/fphar.2020.526349.
  • Khan, T., A. Date, H. Chawda, and K. Patel. 2019. Polysaccharides as potential anticancer agents: A review of their progress. Carbohydrate Polymers 210:412–28. doi: 10.1016/j.carbpol.2019.01.064.
  • King, D., D. Yeomanson, and H. E. Bryant. 2015. PI3King the lock: Targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma. Journal of Pediatric Hematology/Oncology 37 (4):245–51. doi: 10.1097/Mph.0000000000000329.
  • Kwon, M. J., and T. J. Nam. 2007. A polysaccharide of the marine alga Capsosiphon fulvescens induces apoptosis in AGS gastric cancer cells via an IGF-IR-mediated PI3K/Akt pathway. Cell Biology International 31 (8):768–75. doi: 10.1016/j.cellbi.2007.01.010.
  • Leal-Esteban, L. C., and L. Fajas. 2020. Cell cycle regulators in cancer cell metabolism. Biochimica et Biophysica Acta - Molecular Basis of Disease 1866:165715. doi: 10.1016/j.bbadis.2020.165715.
  • Leclere, L., M. Fransolet, F. Cote, P. Cambier, T. Arnould, P. Van Cutsem, and C. Michiels. 2015. Heat-modified citrus pectin induces apoptosis-like cell death and autophagy in HepG2 and A549 cancer cells. PLoS One 10 (3):e0115831. doi: 10.1371/journal.pone.0115831.
  • Lee, Y., and A. B. Gustafsson. 2009. Role of apoptosis in cardiovascular disease. Apoptosis: An International Journal on Programmed Cell Death 14 (4):536–48. doi: 10.1007/s10495-008-0302-x.
  • Lee, J. S., Q. Li, J. Y. Lee, S. H. Lee, J. H. Jeong, H. R. Lee, H. Chang, F. C. Zhou, S. J. Gao, C. Liang, et al. 2009. FLIP-mediated autophagy regulation in cell death control. Nature Cell Biology 11 (11):1355–62. doi: 10.1038/ncb1980.
  • Liao, Z., J. Zhang, J. Wang, T. Yan, F. Xu, B. Wu, F. Xiao, K. Bi, J. Niu, and Y. Jia. 2019. The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice. International Journal of Biological Macromolecules 140:568–76. doi: 10.1016/j.ijbiomac.2019.08.149.
  • Li, X., H. Gong, S. Yang, L. Yang, Y. Fan, and Y. Zhou. 2017. Pectic bee pollen polysaccharide from Rosa rugosa alleviates diet-induced hepatic steatosis and insulin resistance via induction of AMPK/mTOR-mediated autophagy. Molecules 22 (5):699. doi: 10.3390/molecules22050699.
  • Li, L., K. Thakur, Y. Y. Cao, B. Y. Liao, J. G. Zhang, and Z. J. Wei. 2020. Anticancerous potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua in human cervical cancer Hela cells. International Journal of Biological Macromolecules 148:843–50. doi: 10.1016/j.ijbiomac.2020.01.223.
  • Liu, S. Y., L. Chen, X. C. Li, Q. K. Hu, and L. J. He. 2018. Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats. Journal of Chemical Neuroanatomy 89:37–42. doi: 10.1016/j.jchemneu.2017.12.011.
  • Liu, B., Z.-Z. Shang, Q.-M. Li, X.-Q. Zha, D.-L. Wu, N.-J. Yu, L. Han, D.-Y. Peng, and J.-P. Luo. 2020. Structural features and anti-gastric cancer activity of polysaccharides from stem, root, leaf and flower of cultivated Dendrobium huoshanense. International Journal of Biological Macromolecules 143:651–64. doi: 10.1016/j.ijbiomac.2019.12.041.
  • Liu, W. B., F. Xie, H. Q. Sun, M. Meng, and Z. Y. Zhu. 2017. Anti-tumor effect of polysaccharide from Hirsutella sinensis on human non-small cell lung cancer and nude mice through intrinsic mitochondrial pathway. International Journal of Biological Macromolecules 99:258–64. doi: 10.1016/j.ijbiomac.2017.02.071.
  • Loh, A. H., R. C. Brennan, W. H. Lang, R. J. Hickey, L. H. Malkas, and J. A. Sandoval. 2013. Dissecting the PI3K signaling axis in pediatric solid tumors: Novel targets for clinical integration. Frontiers in Oncology 3:93. doi: 10.3389/fonc.2013.00093.
  • Luo, Z., X. Hu, H. Xiong, H. Qiu, X. Yuan, F. Zhu, Y. Wang, and Y. Zou. 2016. A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein. Carbohydrate Polymers 151:1027–33. doi: 10.1016/j.carbpol.2016.06.046.
  • Ma, L., G. B. Xu, X. Tang, C. Zhang, W. Zhao, J. Wang, and H. Chen. 2020. Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus.) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis. Journal of Functional Foods 64:103677. doi: 10.1016/j.jff.2019.103677.
  • Maejima, Y., M. Isobe, and J. Sadoshima. 2016. Regulation of autophagy by Beclin 1 in the heart. Journal of Molecular and Cellular Cardiology 95:19–25. doi: 10.1016/j.yjmcc.2015.10.032.
  • Malhi, H., and G. J. Gores. 2008. Cellular and molecular mechanisms of liver injury. Gastroenterology 134 (6):1641–54. doi: 10.1053/j.gastro.2008.03.002.
  • Martinet, W., M. W. Knaapen, M. M. Kockx, and G. R. De Meyer. 2007. Autophagy in cardiovascular disease. Trends in Molecular Medicine 13 (11):482–91. doi: 10.1016/j.molmed.2007.08.004.
  • Mizushima, N. 2020. The ATG conjugation systems in autophagy. Current Opinion in Cell Biology 63:1–10. doi: 10.1016/j.ceb.2019.12.001.
  • Mizushima, N., A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, K. Suzuki, T. Tokuhisa, Y. Ohsumi, and T. Yoshimori. 2001. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. The Journal of Cell Biology 152 (4):657–67. doi: 10.1083/jcb.152.4.657.
  • Negroni, A., S. Cucchiara, and L. Stronati. 2015. Apoptosis, necrosis, and necroptosis in the gut and intestinal homeostasis. Mediators of Inflammation 2015:250762. doi: 10.1155/2015/250762.
  • Nikoletopoulou, V., M. Markaki, K. Palikaras, and N. Tavernarakis. 2013. Crosstalk between apoptosis, necrosis and autophagy. Biochimica et Biophysica Acta 1833 (12):3448–59. doi: 10.1016/j.bbamcr.2013.06.001.
  • Pan, H., L. Niu, Y. H. Wu, L. Y. Chen, X. W. Zhou, and Y. Zhao. 2021. Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 activation through autophagy inhibition. Molecular Medicine Reports 24 (5):12418. doi: 10.3892/mmr.2021.12418.
  • Pan, H., Y. Wang, K. Na, Y. Wang, L. Wang, Z. Li, C. Guo, D. Guo, and X. Wang. 2019. Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation. Cell Death & Disease 10 (6):456. doi: 10.1038/s41419-019-1653-7.
  • Ponnusamy, L., S. R. Natarajan, K. Thangaraj, and R. Manoharan. 2020. Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. Biochimica et Biophysica Acta - Reviews on Cancer 1874 (1):188379. doi: 10.1016/j.bbcan.2020.188379.
  • Porta, C., C. Paglino, and A. Mosca. 2014. Targeting PI3K/Akt/mTOR signaling in cancer. Frontiers in Oncology 4:64. doi: 10.3389/fonc.2014.00064.
  • Qi, W., X. Zhou, J. Wang, K. Zhang, Y. Zhou, S. Chen, S. Nie, and M. Xie. 2020. Cordyceps sinensis polysaccharide inhibits colon cancer cells growth by inducing apoptosis and autophagy flux blockage via mTOR signaling. Carbohydrate Polymers 237:116113. doi: 10.1016/j.carbpol.2020.116113.
  • Raish, M. 2017. Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway. International Journal of Biological Macromolecules 97:544–51. doi: 10.1016/j.ijbiomac.2017.01.074.
  • Raish, M., A. Ahmad, M. A. Ansari, K. M. Alkharfy, F. I. Aljenoobi, B. L. Jan, A. M. Al-Mohizea, A. Khan, and N. Ali. 2018. Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition. International Journal of Biological Macromolecules 111:193–9. doi: 10.1016/j.ijbiomac.2018.01.008.
  • Ren, Q., S. Zhao, C. Ren, and Z. Ma. 2018. Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts. International Journal of Immunopathology and Pharmacology 31:205873841875918. doi: 10.1177/2058738418759180.
  • Rosendahl, A. H., C. Sun, D. Wu, and R. Andersson. 2012. Polysaccharide-K (PSK) increases p21(WAF/Cip1) and promotes apoptosis in pancreatic cancer cells. Pancreatology 12 (6):467–74. doi: 10.1016/j.pan.2012.09.004.
  • Rubinstein, A. D., M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi. 2011. The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Molecular Cell 44 (5):698–709. doi: 10.1016/j.molcel.2011.10.014.
  • Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. The Faseb Journal 9 (9):726–35. doi: 10.1096/fasebj.9.9.7601337.
  • Shi, G. J., J. Zheng, X. X. Han, Y. P. Jiang, Z. M. Li, J. Wu, Q. Chang, Y. Niu, T. Sun, Y. X. Li, et al. 2018. Lycium barbarum polysaccharide attenuates diabetic testicular dysfunction via inhibition of the PI3K/Akt pathway-mediated abnormal autophagy in male mice. Cell and Tissue Research 374 (3):653–66. doi: 10.1007/s00441-018-2891-1.
  • Sun, W. Y., K. Qian, K. Guo, L. L. Chen, J. Xiang, D. S. Li, Y. Wu, Q. H. Ji, T. Q. Sun, and Z. Y. Wang. 2020. LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway. Acta Biochimica et Biophysica Sinica 52 (4):382–9. doi: 10.1093/abbs/gmaa015.
  • Sun, P., D. Sun, and X. Wang. 2017. Effects of Scutellaria barbata polysaccharide on the proliferation, apoptosis and EMT of human colon cancer HT29 Cells. Carbohydrate Polymers 167:90–6. doi: 10.1016/j.carbpol.2017.03.022.
  • Suzuki, K., T. Kirisako, Y. Kamada, N. Mizushima, T. Noda, and Y. Ohsumi. 2001. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. The EMBO Journal 20 (21):5971–81. doi: 10.1093/emboj/20.21.5971.
  • Wang, Y., S. Wang, R. Song, J. Cai, J. Xu, X. Tang, and N. Li. 2019. Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules 123:81–90. doi: 10.1016/j.ijbiomac.2018.10.169.
  • Wang, X. Y., D. D. Zhang, J. Y. Yin, S. P. Nie, and M. Y. Xie. 2019. Recent developments in Hericium erinaceus polysaccharides: Extraction, purification, structural characteristics and biological activities. Critical Reviews in Food Science and Nutrition 59 (sup1):S96–S115. doi: 10.1080/10408398.2018.1521370.
  • White, E. 2001. Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus. Oncogene 20 (54):7836–46. doi: 10.1038/sj.onc.1204861.
  • Wong, S., K. Wong, L. Chiu, and P. Cheung. 2007. Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction. Carbohydrate Polymers 68 (2):206–17. doi: 10.1016/j.carbpol.2006.12.018.
  • Wu, G., Z. Bai, Y. Wan, H. Shi, X. Huang, and S. Nie. 2020. Antidiabetic effects of polysaccharide from azuki bean (Vigna angularis) in type 2 diabetic rats via insulin/PI3K/AKT signaling pathway. Food Hydrocolloids 101:105456. doi: 10.1016/j.foodhyd.2019.105456.
  • Xie, J. H., M. L. Jin, G. A. Morris, X. Q. Zha, H. Q. Chen, Y. Yi, J. E. Li, Z. J. Wang, J. Gao, S. P. Nie, et al. 2016. Advances on bioactive polysaccharides from medicinal plants. Critical Reviews in Food Science and Nutrition 56 (Suppl 1):S60–S84. doi: 10.1080/10408398.2015.1069255.
  • Xie, Q., Y. Liu, and X. Li. 2020. The interaction mechanism between autophagy and apoptosis in colon cancer. Translational Oncology 13 (12):100871. doi: 10.1016/j.tranon.2020.100871.
  • Xu, J., Z. C. Tan, Z. Y. Shen, X. J. Shen, and S. M. Tang. 2021. Cordyceps cicadae polysaccharides inhibit human cervical cancer hela cells proliferation via apoptosis and cell cycle arrest. Food and Chemical Toxicology 148:111971. doi: 10.1016/j.fct.2021.111971.
  • Xue, L. Z., G. C. Fletcher, and A. M. Tolkovsky. 1999. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution. Molecular and Cellular Neuroscience 14 (3):180–98. doi: 10.1006/mcne.1999.0780.
  • Yamasaki, Y., M. Yamasaki, H. Tachibana, and K. Yamada. 2012. Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation. Bioscience, Biotechnology, and Biochemistry 76 (6):1163–8. doi: 10.1271/bbb.111001.
  • Yan, J. K., J. J. Pei, H. L. Ma, Z. B. Wang, and Y. S. Liu. 2017. Advances in antitumor polysaccharides from phellinus sensu lato: Production, isolation, structure, antitumor activity, and mechanisms. Critical Reviews in Food Science and Nutrition 57 (6):1256–69. doi: 10.1080/10408398.2014.984802.
  • Yang, L., P. Li, S. N. Fu, E. S. Calay, and G. S. Hotamisligil. 2010. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism 11 (6):467–78. doi: 10.1016/j.cmet.2010.04.005.
  • Yang, S., Y. Qu, H. Zhang, Z. Xue, T. Liu, L. Yang, L. Sun, Y. Zhou, and Y. Fan. 2020. Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms. Food & Function 11 (1):424–34. doi: 10.1039/c9fo02283j.
  • Ye, Y. H., D. S. Ji, L. J. You, L. Zhou, Z. G. Zhao, and C. Brennan. 2018. Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice. Journal of Functional Foods 43:8–16. doi: 10.1016/j.jff.2018.01.025.
  • Ying, M., B. Zheng, Q. Yu, K. Hou, H. Wang, M. Zhao, Y. Chen, J. Xie, S. Nie, and M. Xie. 2020. Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associated with autophagy in immunosuppressed mice. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 138:111244. doi: 10.1016/j.fct.2020.111244.
  • Yu, S., H. Ji, X. Dong, A. Liu, and J. Yu. 2020. FAS/FAS-L-mediated apoptosis and autophagy of SPC-A-1 cells induced by water-soluble polysaccharide from Polygala tenuifolia. International Journal of Biological Macromolecules 150:449–58. doi: 10.1016/j.ijbiomac.2020.02.010.
  • Yu, J., R. Sun, Z. Zhao, and Y. Wang. 2014. Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells. International Journal of Biological Macromolecules 68:67–71. doi: 10.1016/j.ijbiomac.2014.04.018.
  • Yu, J., and L. Zhang. 2005. The transcriptional targets of p53 in apoptosis control. Biochemical and Biophysical Research Communications 331 (3):851–8. doi: 10.1016/j.bbrc.2005.03.189.
  • Zada, S., J. S. Hwang, M. Ahmed, T. H. Lai, T. M. Pham, O. Elashkar, and D. R. Kim. 2021. Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy. Biochimica et Biophysica Acta - Reviews on Cancer 1876 (1):188565. doi: 10.1016/j.bbcan.2021.188565.
  • Zhang, J. Y., Y. Guo, J. P. Si, X. B. Sun, G. B. Sun, and J. J. Liu. 2017. A polysaccharide of Dendrobium officinale ameliorates H2O2-induced apoptosis in H9c2 cardiomyocytes via PI3K/AKT and MAPK pathways. International Journal of Biological Macromolecules 104 (Pt A):1–10. doi: 10.1016/j.ijbiomac.2017.05.169.
  • Zhang, Y., Z. He, X. Liu, Z. Chen, J. Sun, Z. Wu, X. Yang, X. Chen, Z. Tang, and K. Wang. 2019. Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: Pancreatic β-cell apoptosis inhibition. Journal of Functional Foods 54:361–70. doi: 10.1016/j.jff.2019.01.037.
  • Zhao, K., M. Jin, Q. Chen, and P.-S. Zheng. 2015. Polysaccharides produced by Enterobacter cloacae induce apoptosis in cervical cancer cells. International Journal of Biological Macromolecules 72:960–4. doi: 10.1016/j.ijbiomac.2014.09.047.
  • Zhao, F., J. Zhao, L. Song, Y. Q. Zhang, Z. Guo, and K. H. Yang. 2017. The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Apoptosis: An International Journal on Programmed Cell Death 22 (11):1461–72. doi: 10.1007/s10495-017-1421-z.
  • Zheng, B., M. Ying, J. Xie, Y. Chen, Y. Wang, X. Ding, J. Hong, W. Liao, and Q. Yu. 2020. A Ganoderma atrum polysaccharide alleviated DSS-induced ulcerative colitis by protecting the apoptosis/autophagy-regulated physical barrier and the DC-related immune barrier. Food & Function 11 (12):10690–9. doi: 10.1039/d0fo02260h.
  • Zhu, B., Y. Li, T. Hu, and Y. Zhang. 2019. The hepatoprotective effect of polysaccharides from Pleurotus ostreatus on carbon tetrachloride-induced acute liver injury rats. International Journal of Biological Macromolecules 131:1–9. doi: 10.1016/j.ijbiomac.2019.03.043.

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