4,686
Views
8
CrossRef citations to date
0
Altmetric
Review Articles

Bioactive food components for colorectal cancer prevention and treatment: A good match

, , , , , , , & show all

References

  • Adams, B. K., J. Cai, J. Armstrong, M. Herold, Y. J. Lu, A. Sun, J. P. Snyder, D. C. Liotta, D. P. Jones, and M. Shoji. 2005. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer. Drugs 16:263–75.
  • Ahmed, K., S. F. Zaidi, Z.-G. Cui, D. Zhou, S. A. Saeed, and H. Inadera. 2019. Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer. Oncology Letters 18 (1):487–98.
  • Altomare, R., F. Cacciabaudo, G. Damiano, V. D. Palumbo, M. C. Gioviale, M. Bellavia, G. Tomasello, and A. I. Lo Monte. 2013. The Mediterranean diet: A history of health. Iranian Journal of Public Health 42 (5):449–57.
  • American Dietetic Association. ADA – comments on defining bioactive food components vdocuments .net.
  • Amini, P., S. J. Nodooshan, M. Ashrafizadeh, S.-M. Eftekhari, T. Aryafar, L. Khalafi, A. E. Musa, S. R. Mahdavi, M. Najafi, and B. Farhood. 2020. Resveratrol induces apoptosis and attenuates proliferation of MCF-7 cells in combination with radiation and hyperthermia. Current Molecular Medicine 21:142–150.
  • Arya, V. S., S. K. Kanthlal, and G. Linda. 2020. The role of dietary polyphenols in inflammatory bowel disease: A possible clue on the molecular mechanisms involved in the prevention of immune and inflammatory reactions. Journal of Food Biochemistry 44 (11):e13369. doi: 10.1111/jfbc.13369.
  • Atashpour, S., S. Fouladdel, T. K. Movahhed, E. Barzegar, M. H. Ghahremani, S. N. Ostad, and E. Azizi. 2015. Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin. Iranian Journal of Basic Medical Sciences 18 (7):635–43.
  • Bagetta, D., A. Maruca, A. Lupia, F. Mesiti, R. Catalano, I. Romeo, F. Moraca, F. A. Ambrosio, G. Costa, A. Artese, et al. 2020. Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome. European Journal of Medicinal Chemistry 186:111903.
  • Bagheri, R., Z. Sanaat, and N. Zarghami. 2018. Synergistic effect of free and nano-encapsulated chrysin-curcumin on inhibition of hTERT gene expression in SW480 colorectal cancer cell line. Drug Research 68 (6):335–43. doi: 10.1055/s-0043-121338.
  • Banerjee, K., and M. Mandal. 2015. Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. Redox Biology 5:153–62. doi: 10.1016/j.redox.2015.04.009.
  • Berretta, M., A. Bignucolo, R. D. Francia, F. Comello, G. Facchini, M. Ceccarelli, R. V. Iaffaioli, V. Quagliariello, and N. Maurea. 2020. Resveratrol in cancer patients: From bench to bedside. International Journal of Molecular Sciences 21:2945.
  • Blanquer-Rosselló, M. D. M., R. Hernández-López, P. Roca, J. Oliver, and A. Valle. 2017. Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells. Biochimica et Biophysica Acta. General Subjects 1861 (2):431–40. doi: 10.1016/j.bbagen.2016.10.009.
  • Buhrmann, C., M. Yazdi, B. Popper, A. Kunnumakkara, B. Aggarwal, and M. Shakibaei. 2019. Induction of the epithelial-to-mesenchymal transition of human colorectal cancer by human TNF-β (lymphotoxin) and its reversal by resveratrol. Nutrients 11 (3):704. doi: 10.3390/nu11030704.
  • Buhrmann, C., M. Yazdi, B. Popper, P. Shayan, A. Goel, B. Aggarwal, and M. Shakibaei. 2018. Resveratrol chemosensitizes TNF-β-induced survival of 5-FU-treated colorectal cancer cells. Nutrients 10 (7):888. doi: 10.3390/nu10070888.
  • Buhrmann, C., P. Shayan, A. Goel, and M. Shakibaei. 2017. Resveratrol regulates colorectal cancer cell invasion by modulation of focal adhesion molecules. Nutrients 9 (10):1073. doi: 10.3390/nu9101073.
  • Buhrmann, C., P. Shayan, P. Kraehe, B. Popper, A. Goel, and M. Shakibaei. 2015. Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochemical Pharmacology 98 (1):51–68.
  • Caetano, B. F. R., M. B. Tablas, N. E. F. Pereira, N. A. de Moura, R. F. Carvalho, M. A. M. Rodrigues, and L. F. Barbisan. 2018. Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats. Toxicology and Applied Pharmacology 338:93–102.
  • Calibasi-Kocal, G., A. Pakdemirli, S. Bayrak, N. M. Ozupek, T. Sever, Y. Basbinar, H. Ellidokuz, and T. Yigitbasi. 2019. Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer. Journal of BUON 24:1482–7.
  • Carroll, R. E., R. V. Benya, D. K. Turgeon, S. Vareed, M. Neuman, L. Rodriguez, M. Kakarala, P. M. Carpenter, C. McLaren, F. L. Meyskens, et al. 2011. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prevention Research 4 (3):354–64. doi: 10.1158/1940-6207.CAPR-10-0098.
  • Chan, J. Y., M. S. Phoo, M.-V. Clement, S. Pervaiz, and S. C. Lee. 2008. Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53. Cancer Biology & Therapy 7 (8):1305–12. doi: 10.4161/cbt.7.8.6302.
  • Cheah, F. K., K. H. Leong, N. F. Thomas, H. K. Chin, A. Ariffin, and K. Awang. 2018. Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53-p21CIP1/WAF1 in human colorectal HCT116 cells. Apoptosis 23 (5-6):329–42. doi: 10.1007/s10495-018-1457-8.
  • Chen, G.-P., Y. Zhang, Z.-Y. Xu, J.-F. Yu, and X. Wei. 2017. Curcumin combined with cis-platinum promote the apoptosis of human colorectal cancer HT29 cells and mechanism. International Journal of Clinical and Experimental Pathology 10 (12):11496–505.
  • Chen, J., A. Katsifis, C. Hu, and X.-F. Huang. 2011. Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway. Current Drug Discovery Technologies 8 (2):119–25.
  • Chen, L., and A. E. Musa. 2021. Boosting immune system against cancer by resveratrol. Phytotherapy Research 35 (10):5514–5526.
  • Chen, W. T.-L., T.-S. Yang, H.-C. Chen, H.-H. Chen, H.-C. Chiang, T.-C. Lin, C.-H. Yeh, T.-W. Ke, J.-S. Chen, K.-H. Hsiao, et al. 2014. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil–based chemotherapy in colorectal cancer. Nutrition Research 34 (7):585–94.
  • Chen, X., H. Liang, Q. Song, X. Xu, and D. Cao. 2018. Insulin promotes progression of colon cancer by upregulation of ACAT1. Lipids in Health and Disease 17 (1):122. doi: 10.1186/s12944-018-0773-x.
  • Cheung, K. L., T. O. Khor, and A.-N. Kong. 2009. Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. Pharmaceutical Research 26 (1):224–31. doi: 10.1007/s11095-008-9734-9.
  • Chung, S. S., P. Dutta, D. Austin, P. Wang, A. Awad, and J. V. Vadgama. 2018. Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget 9 (68):32943–57. doi: 10.18632/oncotarget.25993.
  • Colpan, R. D., and A. Erdemir. 2021. Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells. Journal of Microencapsulation 38 (6):381–93. doi: 10.1080/02652048.2021.1948623.
  • Couto, E., P. Boffetta, P. Lagiou, P. Ferrari, G. Buckland, K. Overvad, C. C. Dahm, A. Tjønneland, A. Olsen, F. Clavel-Chapelon, et al. 2011. Mediterranean dietary pattern and cancer risk in the EPIC cohort. British Journal of Cancer 104 (9):1493–9. doi: 10.1038/bjc.2011.106.
  • Cruz-Correa, M., D. A. Shoskes, P. Sanchez, R. Zhao, L. M. Hylind, S. D. Wexner, and F. M. Giardiello. 2006. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clinical Gastroenterology and Hepatology 4:1035–8.
  • Cruz-Correa, M., L. M. Hylind, J. H. Marrero, M. L. Zahurak, T. Murray-Stewart, R. A. Casero, E. A. Montgomery, C. Iacobuzio-Donahue, L. A. Brosens, G. J. Offerhaus, et al. 2018. Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Gastroenterology 155 (3):668–73. doi: 10.1053/j.gastro.2018.05.031.
  • Darband, S. G., S. Sadighparvar, B. Yousefi, M. Kaviani, F. Ghaderi-Pakdel, A. Mihanfar, Y. Rahimi, K. Mobaraki, and M. Majidinia. 2020. Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis. Life Sciences 253:117584. doi: 10.1016/j.lfs.2020.117584.
  • Deng, L.-J., M. Qi, N. Li, Y.-H. Lei, D.-M. Zhang, and J.-X. Chen. 2020. Natural products and their derivatives: Promising modulators of tumor immunotherapy. Journal of Leukocyte Biology 108 (2):493–508.
  • Dent, P., L. Booth, J. L. Roberts, A. Poklepovic, and J. F. Hancock. 2020. (Curcumin + sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo. Journal of Cellular Physiology 235 (10):6862–74.
  • Du, B., L. Jiang, Q. Xia, and L. Zhong. 2006. Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy 52 (1):23–8. doi: 10.1159/000090238.
  • Ebrahimi, M., E. Babaei, F. Neri, and M. A. H. Feizi. 2021. Anti-proliferative and apoptotic effect of Gemini curcumin in p53-wild type and p53-mutant colorectal cancer cell lines. International Journal of Pharmaceutics 601:120592. doi: 10.1016/j.ijpharm.2021.120592.
  • Farinetti, A., V. Zurlo, A. Manenti, F. Coppi, and A. V. Mattioli. 2017. Mediterranean diet and colorectal cancer: A systematic review. Nutrition 43–44:83–8. doi: 10.1016/j.nut.2017.06.008.
  • Feng, J., D. Song, S. Jiang, XHui Yang, T. Ding, H. Zhang, J. Luo, J. Liao, and Q. Yin. 2018. Quercetin restrains TGF-β1-induced epithelial–mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression. Biochemical and Biophysical Research Communications 498 (1):132–8.
  • Fernando, W., H. P. V. Rupasinghe, and D. W. Hoskin. 2019. Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy? Cancer Letters 452:168–77. doi: 10.1016/j.canlet.2019.03.022.
  • Garcea, G., D. P. Berry, D. J. L. Jones, R. Singh, A. R. Dennison, P. B. Farmer, R. A. Sharma, W. P. Steward, and A. J. Gescher. 2005. Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiology, Biomarkers & Prevention 14:120–5.
  • Gavrilas, L. I., D. Cruceriu, C. Ionescu, D. Miere, and O. Balacescu. 2019. Pro-apoptotic genes as new targets for single and combinatorial treatments with resveratrol and curcumin in colorectal cancer. Food & Function 10 (6):3717–26. doi: 10.1039/C9FO01014A.
  • Giordano, A., and G. Tommonaro. 2019. Curcumin and cancer. Nutrients 11:2376. doi: 10.3390/nu11102376.
  • Girardi, B., M. Principi, M. Pricci, F. Giorgio, A. Iannone, G. Losurdo, E. Ierardi, A. Di Leo, and M. Barone. 2018. Chemoprevention of inflammation-related colorectal cancer by silymarin-, acetyl-11-keto-beta-boswellic acid-, curcumin- and maltodextrin-enriched dietetic formulation in animal model. Carcinogenesis 39 (10):1274–82. doi: 10.1093/carcin/bgy104.
  • Grabacka, M. M., M. Gawin, and M. Pierzchalska. 2014. Phytochemical modulators of mitochondria: The search for chemopreventive agents and supportive therapeutics. Pharmaceuticals 7:913–42.
  • Gran, E. R., V. Lotocki, Q. Zhang, J. Antel, A. Kakkar, and D. Maysinger. 2021. Human astrocytes and astrocytoma respond differently to resveratrol. Nanomedicine 37:102441. doi: 10.1016/j.nano.2021.102441.
  • Greil, R., S. Greil-Ressler, L. Weiss, C. Schönlieb, T. Magnes, B. Radl, G. T. Bolger, B. Vcelar, and P. P. Sordillo. 2018. A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer. Cancer Chemotherapy and Pharmacology 82 (4):695–706. doi: 10.1007/s00280-018-3654-0.
  • Griswold, M. G., N. Fullman, C. Hawley, N. Arian, S. R. M. Zimsen, H. D. Tymeson, V. Venkateswaran, A. D. Tapp, M. H. Forouzanfar, J. S. Salama, et al. 2018. Alcohol use and burden for 195 countries and territories, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet 392 (10152):1015–35. doi: 10.1016/S0140-6736(18)31310-2.
  • Guazelli, C. F. S., V. Fattori, B. B. Colombo, S. R. Georgetti, F. T. M. C. Vicentini, R. Casagrande, M. M. Baracat, and W. A. Verri. 2013. Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms. Journal of Natural Products 76 (2):200–8.
  • Han, W., H. Yin, H. Ma, Y. Wang, D. Kong, and Z. Fan. 2020. Curcumin regulates ERCC1 expression and enhances oxaliplatin sensitivity in resistant colorectal cancer cells through its effects on miR-409-3p. Evidence-Based Complementary and Alternative Medicine 2020:8394574.
  • Hatcher, H., R. Planalp, J. Cho, F. M. Torti, and S. V. Torti. 2008. Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences 65 (11):1631–52. doi: 10.1007/s00018-008-7452-4.
  • Hasler, C. M., and A. C. Brown. 2009. Position of the American Dietetic Association: functional foods. Journal of the American Dietetic Association 109 (4):735–46. doi:10.1016/j.jada.2009.02.023. PMID:19338113
  • Howells, L. M., C. O. O. Iwuji, G. R. B. Irving, S. Barber, H. Walter, Z. Sidat, N. Griffin-Teall, R. Singh, N. Foreman, S. R. Patel, et al. 2019. Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial. The Journal of Nutrition 149 (7):1133–9. doi: 10.1093/jn/nxz029.
  • Howells, L. M., D. P. Berry, P. J. Elliott, E. W. Jacobson, E. Hoffmann, B. Hegarty, K. Brown, W. P. Steward, and A. J. Gescher. 2011. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prevention Research 4 (9):1419–25. doi: 10.1158/1940-6207.CAPR-11-0148.
  • Hu, W.-H., G. K.-L. Chan, R. Duan, H.-Y. Wang, X.-P. Kong, T. T.-X. Dong, K. W.-K. Tsim. 2019. Synergy of ginkgetin and resveratrol in suppressing VEGF-induced angiogenesis: A therapy in treating colorectal cancer. Cancers 11:1828. doi: 10.3390/cancers11121828.
  • Imperial College London. 2018. WCRF/AICR systematic literature review Continuous Update Project report: The associations between food nutrition and physical activity and the risk of colorectal cancer -Revised 2018.
  • James, M. I., C. Iwuji, G. Irving, A. Karmokar, J. A. Higgins, N. Griffin-Teal, A. Thomas, P. Greaves, H. Cai, S. R. Patel, et al. 2015. Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy. Cancer Letters 364 (2):135–41. doi: 10.1016/j.canlet.2015.05.005.
  • Jantan, I., M. A. Haque, L. Arshad, H. Harikrishnan, A. W. Septama, and Z.-A. Mohamed-Hussein. 2021. Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. The Journal of Nutritional Biochemistry 93:108634.
  • Jesus, M. S., A. C. Carvalho, J. A. Teixeira, L. Domingues, and C. Pereira-Wilson. 2020. Ohmic heating extract of vine pruning residue has anti-colorectal cancer activity and increases sensitivity to the chemotherapeutic drug 5-FU. Foods Basel Foods 9 (8):1102. doi: 10.3390/foods9081102.
  • Ji, Q., X. Liu, X. Fu, L. Zhang, H. Sui, L. Zhou, J. Sun, J. Cai, J. Qin, J. Ren, et al. 2013. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One 8 (11):e78700. doi: 10.1371/journal.pone.0078700.
  • Ji, Q., X. Liu, Z. Han, L. Zhou, H. Sui, L. Yan, H. Jiang, J. Ren, J. Cai, Q. Li, et al. 2015. Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression. BMC Cancer 15:97. doi: 10.1186/s12885-015-1119-y.
  • Jia, F., Y. Li, X. Deng, X. Wang, X. Cui, J. Lu, Z. Pan, and Y. Wu. 2021. Self-assembled fluorescent hybrid nanoparticles-mediated collaborative lncRNA CCAT1 silencing and curcumin delivery for synchronous colorectal cancer theranostics. Journal of Nanobiotechnology 19:238.
  • Jin, H., and C. Zhang. 2020. High fat high calories diet (HFD) increase gut susceptibility to carcinogens by altering the gut microbial community. Journal of Cancer 11 (14):4091–8. doi: 10.7150/jca.43561.
  • Jin, J., G. Lin, H. Huang, D. Xu, H. Yu, X. Ma, L. Zhu, D. Ma, and H. Jiang. 2014. Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. International Journal of Biological Sciences 10(3):285– 95.
  • Johnson, I. T., and E. K. Lund. 2007. Review article: Nutrition, obesity and colorectal cancer. Alimentary Pharmacology & Therapeutics 26 (2):161–81.
  • Jozkowiak, M., P. Skupin-Mrugalska, A. Nowicki, S. Borys-Wojcik, M. Wierzchowski, M. Kaczmarek, P. Ramlau, J. Jodynis-Liebert, and H. Piotrowska-Kempisty. 2020. The effect of 4′-hydroxy-3,4,5-trimetoxystilbene, the metabolite of resveratrol analogue DMU-212, on growth, cell cycle and apoptosis in DLD-1 and LOVO colon cancer cell lines. Nutrients 12 (5):1327. doi: 10.3390/nu12051327.
  • Juan, M. E., U. Wenzel, H. Daniel, and J. M. Planas. 2008. Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. Journal of Agricultural and Food Chemistry 56 (12):4813–8. doi: 10.1021/jf800175a.
  • Kaminski, B. M., A. Weigert, B. Brüne, M. Schumacher, U. Wenzel, D. Steinhilber, J. Stein, and S. Ulrich. 2011. Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. Cancer Chemotherapy and Pharmacology 67 (5):1167–78. doi: 10.1007/s00280-010-1413-y.
  • Kee, J.-Y., Y.-H. Han, D.-S. Kim, J.-G. Mun, J. Park, M.-Y. Jeong, J.-Y. Um, and S.-H. Hong. 2016. Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability. Phytomedicine 23 (13):1680–90. doi: 10.1016/j.phymed.2016.09.011.
  • Khaleel, S. A., A. M. Al-Abd, A. A. Ali, and A. B. Abdel-Naim. 2016. Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. Scientific Reports 6:36855.
  • Khan, I., S. Paul, R. Jakhar, M. Bhardwaj, J. Han, and S. C. Kang. 2016. Novel quercetin derivative TEF induces ER stress and mitochondria-mediated apoptosis in human colon cancer HCT-116 cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 84:789–99. doi: 10.1016/j.biopha.2016.09.094.
  • Kim, E., G. A. Wright, R. S. Zoh, B. S. Patil, G. K. Jayaprakasha, E. S. Callaway, I. Ivanov, N. D. Turner, and R. S. Chapkin. 2019. Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model. European Journal of Cancer Prevention 28 (5):383–9. doi: 10.1097/CEJ.0000000000000465.
  • Kim, Y. S., M. R. Young, G. Bobe, N. H. Colburn, and J. A. Milner. 2009. Bioactive food components, inflammatory targets, and cancer prevention. Cancer Prevention Research 2 (3):200–8. doi: 10.1158/1940-6207.CAPR-08-0141.
  • Kunnumakkara, A. B., P. Diagaradjane, S. Guha, A. Deorukhkar, S. Shentu, B. B. Aggarwal, and S. Krishnan. 2008. Curcumin sensitizes human colorectal cancer xenografts in nude mice to γ-radiation by targeting nuclear factor-κB–regulated gene products. Clinical Cancer Research 14 (7):2128–36. doi: 10.1158/1078-0432.CCR-07-4722.
  • Langner, E., M. K. Lemieszek, and W. Rzeski. 2019. Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro. Journal of Food Biochemistry 43 (4):e12802. doi: 10.1111/jfbc.12802.
  • Lee, S.-R., H. Jin, W.-T. Kim, W.-J. Kim, S. Z. Kim, S.-H. Leem, and S. M. Kim. 2018. Tristetraprolin activation by resveratrol inhibits the proliferation and metastasis of colorectal cancer cells. International Journal of Oncology 53 (3):1269–78.
  • Lee, Y., H. Shin, and J. Kim. 2021. In vivo anti-cancer effects of resveratrol mediated by NK cell activation. Journal of Innate Immunity 13 (2):94–106. doi: 10.1159/000510315.
  • Lee, Y.-J., and J. Kim. 2020. Resveratrol activates natural killer cells through Akt- and mTORC2-mediated c-Myb upregulation. International Journal of Molecular Sciences 21 (24):9575. doi: 10.3390/ijms21249575.
  • Li, M., G. G.-L. Yue, S. K.-W. Tsui, K.-P. Fung, and C. B.-S. Lau. 2018. Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. Phytomedicine 46:131–41.
  • Liang, J., G. M. Hänsch, K. Hübner, and Y. Samstag. 2019. Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells. Advances in Biological Regulation 71:79–87.
  • Liang, Y. C., S. H. Tsai, D. C. Tsai, S. Y. Lin-Shiau, and J. K. Lin. 2001. Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Letters 496 (1):12–8. doi: 10.1016/S0014-5793(01)02393-6.
  • Lin, C., Y. Yu, H.-g. Zhao, A. Yang, H. Yan, and Y. Cui. 2012. Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo. Radiotherapy and Oncology 104 (3):395–400. doi: 10.1016/j.radonc.2011.10.023.
  • Lin, S.-R., C.-H. Chang, C.-F. Hsu, M.-J. Tsai, H. Cheng, M. K. Leong, P.-J. Sung, J.-C. Chen, and C.-F. Weng. 2020. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. British Journal of Pharmacology 177 (6):1409–23.
  • Lin, T.-A., W.-S. Lin, Y.-C. Chou, K. Nagabhushanam, C.-T. Ho, and M.-H. Pan. 2021. Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial-mesenchymal transition and microRNA. Food & Function 12 (20):9658–68. doi: 10.1039/d1fo01920a.
  • Liu, Z., X. Wu, J. Lv, H. Sun, and F. Zhou. 2019. Resveratrol induces p53 in colorectal cancer through SET7/9. Oncology Letters 17 (4):3783–9.
  • Lu, J.-J., Y.-J. Cai, and J. Ding. 2011. Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells. Molecular and Cellular Biochemistry 354 (1-2):247–52.
  • Majumdar, A. P. N., S. Banerjee, J. Nautiyal, B. B. Patel, V. Patel, J. Du, Y. Yu, A. A. Elliott, E. Levi, F. H. Sarkar, et al. 2009. Curcumin synergizes with resveratrol to inhibit colon cancer. Nutrition and Cancer 61 (4):544–53.
  • Manach, C., A. Scalbert, C. Morand, C. Rémésy, and L. Jiménez. 2004. Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition 79 (5):727–47.
  • Manna, S. K., A. Mukhopadhyay, and B. B. Aggarwal. 1950. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation. Journal of Immunology 164:6509–19.
  • Marjaneh, R. M., F. Rahmani, S. M. Hassanian, N. Rezaei, M. Hashemzehi, A. Bahrami, F. Ariakia, H. Fiuji, A. Sahebkar, A. Avan, et al. 2018. Phytosomal curcumin inhibits tumor growth in colitis-associated colorectal cancer. Journal of Cellular Physiology 233 (10):6785–98.
  • Matsuno, Y., Y. Atsumi, M. Alauddin, M. M. Rana, H. Fujimori, M. Hyodo, A. Shimizu, T. Ikuta, H. Tani, and H. Torigoe. 2020. Resveratrol and its related polyphenols contribute to the maintenance of genome stability. Scientific Reports 10:5388.
  • Matsuoka, T., and M. Yashiro. 2020. Precision medicine for gastrointestinal cancer: Recent progress and future perspective. World Journal of Gastrointestinal Oncology 12 (1):1–20.
  • Medina-Remón, A., R. Casas, A. Tressserra-Rimbau, E. Ros, M. A. Martínez-González, M. Fitó, D. Corella, J. Salas-Salvadó, R. M. Lamuela-Raventos, R. Estruch, et al. 2017. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A substudy of the PREDIMED trial. British Journal of Clinical Pharmacology 83 (1):114–28. doi: 10.1111/bcp.12986.
  • Mentella, M. C., F. Scaldaferri, C. Ricci, A. Gasbarrini, and G. A. D. Miggiano. 2019. Cancer and Mediterranean diet: A review. Nutrients 11:2059. doi: 10.3390/nu11092059.
  • Miki, H., N. Uehara, A. Kimura, T. Sasaki, T. Yuri, K. Yoshizawa, and A. Tsubura. 2012. Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. International Journal of Oncology 40 (4):1020–8.
  • Mortezaee, K., M. Najafi, B. Farhood, A. Ahmadi, D. Shabeeb, and A. E. Musa. 2020. Resveratrol as an adjuvant for normal tissues protection and tumor sensitization. Current Cancer Drug Targets 20 (2):130–45. doi: 10.2174/1568009619666191019143539.
  • Mudduluru, G., J. N. George-William, S. Muppala, I. A. Asangani, R. Kumarswamy, L. D. Nelson, and H. Allgayer. 2011. Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer. Bioscience Reports 31 (3):185–97. [Database] doi: 10.1042/BSR20100065.
  • Nagaraju, G. P., ed. 2020. Phytochemicals targeting tumor microenvironment in gastrointestinal cancers. Springer International Publishing.
  • Nautiyal, J., S. S. Kanwar, Y. Yu, and A. P. Majumdar. 2011. Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. Journal of Molecular Signaling 6 (7):7.
  • Nguyen, K. A., Y. Cao, J. R. Chen, C. M. Townsend, and T. C. Ko. 2006. Dietary fiber enhances a tumor suppressor signaling pathway in the gut. Annals of Surgery 243 (5):619–27.
  • Okonkwo, A., J. Mitra, G. S. Johnson, L. Li, W. M. Dashwood, M. L. Hegde, C. Yue, R. H. Dashwood, and P. Rajendran. 2018. Heterocyclic analogs of sulforaphane trigger DNA damage and impede DNA repair in colon cancer cells: Interplay of HATs and HDACs. Molecular Nutrition & Food Research 62 (18):e1800228. doi: 10.1002/mnfr.201800228.
  • Parkin, D., S. Whelan, J. Ferlay, L. Teppo, and D. B. Thomas. 2022. Cancer incidence in five continents, Vol. VIII. IARC Scientific Publication No. 155.
  • Patel, B. B., D. Gupta, A. A. Elliott, V. Sengupta, Y. Yu, and A. P. N. Majumdar. 2010. Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. Anticancer Research 30 (2):319–25.
  • Patel, B. B., R. Sengupta, S. Qazi, H. Vachhani, Y. Yu, A. K. Rishi, and A. P. N. Majumdar. 2008. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. International Journal of Cancer 122 (2):267–73. doi: 10.1002/ijc.23097.
  • Patel, K. R., V. A. Brown, D. J. L. Jones, R. G. Britton, D. Hemingway, A. S. Miller, K. P. West, T. D. Booth, M. Perloff, J. A. Crowell, et al. 2010. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Research 70 (19):7392–9. doi: 10.1158/0008-5472.CAN-10-2027.
  • Pettan-Brewer, C., J. Morton, R. Mangalindan, and W. Ladiges. 2011. Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet. Pathobiology of Aging & Age Related Diseases 1:7281.
  • Raja, S. B., V. Rajendiran, N. K. Kasinathan, A. P, S. Venkatabalasubramanian, M. R. Murali, H. Devaraj, and S. N. Devaraj. 2017. Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. Food and Chemical Toxicology 106:92–106. doi: 10.1016/j.fct.2017.05.006.
  • Rather, R. A., and M. Bhagat. 2020. Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health. Cancer Medicine 9 (24):9181–92. doi: 10.1002/cam4.1411.
  • Ravindranathan, P., D. Pasham, U. Balaji, J. Cardenas, J. Gu, S. Toden, and A. Goel. 2018. A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. Scientific Reports 8 (1):13869.
  • Recio-Boiles, A., and C. B. Cancer. 2020. Colon. StatPearls. Treasure Island, FL: StatPearls Publishing.
  • Reilly, S. M., and A. R. Saltiel. 2017. Adapting to obesity with adipose tissue inflammation. Nature Reviews. Endocrinology 13 (11):633–43.
  • Renaud, S., and M. de Lorgeril. 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. The Lancet 339 (8808):1523–6. doi: 10.1016/0140-6736(92)91277-F.
  • Rizeq, B., I. Gupta, J. Ilesanmi, M. AlSafran, M. M. Rahman, and A. Ouhtit. 2020. The power of phytochemicals combination in cancer chemoprevention. Journal of Cancer 11 (15):4521–33. doi: 10.7150/jca.34374.
  • Roell, K. R., D. M. Reif, and A. A. Motsinger-Reif. 2017. An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines. Frontiers in Pharmacology 8:158.
  • Ryan-Harshman, M., and W. Aldoori. 2007. Diet, and colorectal cancer. Canadian Family Physician Medecin de Famille Canadien 53 (11):1913–20.
  • Saab, M.-B., N. Bec, M. Martin, E. Estephan, F. Cuisinier, C. Larroque, and C. Gergely. 2013. Differential effect of curcumin on the nanomechanics of normal and cancerous Mammalian epithelial cells. Cell Biochemistry and Biophysics 65 (3):399–411.
  • San Hipólito-Luengo, Á., A. Alcaide, M. Ramos-González, E. Cercas, S. Vallejo, A. Romero, E. Talero, C. F. Sánchez-Ferrer, V. Motilva, C. Peiró, et al. 2017. Dual effects of resveratrol on cell death and proliferation of colon cancer cells. Nutrition and Cancer 69 (7):1019–27.
  • Sandur, S. K., A. Deorukhkar, M. K. Pandey, A. M. Pabón, S. Shentu, S. Guha, B. B. Aggarwal, and S. Krishnan. 2009. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-κB activity. International Journal of Radiation Oncology, Biology, Physics 75 (2):534–42.
  • Santandreu, F. M., A. Valle, J. Oliver, and P. Roca. 2011. Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cellular Physiology and Biochemistry 28 (2):219–28. doi: 10.1159/000331733.
  • Sawicki, T., M. Ruszkowska, A. Danielewicz, E. Niedźwiedzka, T. Arłukowicz, and K. E. Przybyłowicz. 2021. A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers 13 (9):2025. doi: 10.3390/cancers13092025.
  • Schwartz, B., and E. Yehuda-Shnaidman. 2014. Putative role of adipose tissue in growth and metabolism of colon cancer cells. Frontiers in Oncology 4:164.
  • Sesarman, A., L. Tefas, B. Sylvester, E. Licarete, V. Rauca, L. Luput, L. Patras, S. Porav, M. Banciu, A. Porfire, et al. 2019. Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment. Drug Delivery and Translational Research 9 (1):260–72.
  • Sharma, R. A., H. R. McLelland, K. A. Hill, C. R. Ireson, S. A. Euden, M. M. Manson, M. Pirmohamed, L. J. Marnett, A. J. Gescher, W. P. Steward, et al. 2001. Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer. Clinical Cancer Research 7 (7):1894–900.
  • Sharma, R. A., S. A. Euden, S. L. Platton, D. N. Cooke, A. Shafayat, H. R. Hewitt, T. H. Marczylo, B. Morgan, D. Hemingway, S. M. Plummer, et al. 2004. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clinical Cancer Research 10 (20):6847–54. [Database] doi: 10.1158/1078-0432.CCR-04-0744.
  • Shree, A., J. Islam, and S. Sultana. 2021. Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, β-catenin. Phytotherapy Research 35 (4):2171–84.
  • Song, J., S. Y. Cheon, W. Jung, W. T. Lee, and J. E. Lee. 2014. Resveratrol induces the expression of interleukin-10 and brain-derived neurotrophic factor in BV2 microglia under hypoxia. International Journal of Molecular Sciences 15 (9):15512–29.
  • Sritharan, S., and N. Sivalingam. 2021. Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. Journal of Biochemical and Molecular Toxicology 35: e22616.
  • Su, P., Y. Yang, G. Wang, X. Chen, and Y. Ju. 2018. Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells. International Journal of Oncology 53 (3):1343–53.
  • Syng-Ai, C., A. L. Kumari, and A. Khar. 2004. Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Molecular Cancer Therapeutics 3 (9):1101–8.
  • Tarozzi, A., C. Angeloni, M. Malaguti, F. Morroni, S. Hrelia, and P. Hrelia. 2013. Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxidative Medicine and Cellular Longevity 2013:415078.
  • Teng, H., Y. Zheng, H. Cao, Q. Huang, J. Xiao, and L. Chen. 2021. Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: A review. Critical Reviews in Food Science and Nutrition, 1–16. doi: 10.1080/10408398.2021.1947772.
  • Thomas, P., Y.-J. Wang, J.-H. Zhong, S. Kosaraju, N. J. O’Callaghan, X.-F. Zhou, and M. Fenech. 2009. Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer’s disease. Mutation Research 661 (1-2):25–34. doi: 10.1016/j.mrfmmm.2008.10.016.
  • Tong, X., L. Yin, S. Joshi, D. W. Rosenberg, and C. Giardina. 2005. Cyclooxygenase-2 regulation in colon cancer cells: Modulation of RNA polymerase II elongation by histone deacetylase inhibitors. The Journal of Biological Chemistry 280 (16):15503–9.
  • Vendrely, V., E. Peuchant, E. Buscail, I. Moranvillier, B. Rousseau, A. Bedel, A. Brillac, H. de Verneuil, F. Moreau-Gaudry, S. Dabernat, et al. 2017. Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. Cancer Letters 390:91–102. doi: 10.1016/j.canlet.2017.01.002.
  • Vendrely, V., S. Amintas, C. Noel, I. Moranvillier, I. Lamrissi, B. Rousseau, S. Coulibaly, A. Bedel, F. Moreau-Gaudry, E. Buscail, et al. 2019. Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death. Cancer Letters 451:1–10. doi: 10.1016/j.canlet.2019.02.038.
  • Vervandier-Fasseur, D., and N. Latruffe. 2019. The potential use of resveratrol for cancer prevention. Molecules 24:4506.
  • Wang, H., X. Cai, and L. Ma. 2020. Curcumin modifies epithelial-mesenchymal transition in colorectal cancer through regulation of miR-200c/EPM5. Cancer Management and Research 12:9405–15.
  • Wang, J., L. Qi, L. Mei, and Z. Wu. 2017. Curcumin inhibits the proliferation and induces apoptosis in HT-29 cell lines through a reactive oxygen species (ROS)-dependent mechanism. Pakistan Journal of Pharmaceutical Sciences 30 (5):1671–7.
  • Wang, Y., W. Wang, X. Wu, C. Li, Y. Huang, H. Zhou, and Y. Cui. 2020. Resveratrol sensitizes colorectal cancer cells to cetuximab by connexin 43 upregulation-induced Akt inhibition. Frontiers in Oncology 10:383. doi: 10.3389/fonc.2020.00383.
  • Widmer, R. J., A. J. Flammer, L. O. Lerman, and A. Lerman. 2015. The Mediterranean diet, its components, and cardiovascular disease. The American Journal of Medicine 128 (3):229–38. doi: 10.1016/j.amjmed.2014.10.014.
  • Witika, B. A., P. A. Makoni, S. K. Matafwali, L. L. Mweetwa, G. C. Shandele, and R. B. Walker. 2021. Enhancement of biological and pharmacological properties of an encapsulated polyphenol: Curcumin. Molecules 26 (14):4244. doi: 10.3390/molecules26144244.
  • Wu, C.-S., S.-Y. Wu, H.-C. Chen, C.-A. Chu, H.-H. Tang, H.-S. Liu, Y.-R. Hong, C.-Y F. Huang, G.-C. Huang, C.-L. Su, et al. 2019. Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib. The Journal of Nutritional Biochemistry 74:108227.
  • Wu, J., J. Yi, Y. Wu, X. Chen, J. Zeng, J. Wu, and W. Peng. 2019. 3, 3’-dimethylquercetin inhibits the proliferation of human colon cancer RKO cells through inducing G2/M cell cycle arrest and apoptosis. Anti-Cancer Agents in Medicinal Chemistry 19 (3):402–9. doi: 10.2174/1871520618666181106120718.
  • Wu, X., G. Y. Koh, Y. Huang, J. W. Crott, R. T. Bronson, and J. B. Mason. 2019. The combination of curcumin and salsalate is superior to either agent alone in suppressing pro-cancerous molecular pathways and colorectal tumorigenesis in obese mice. Molecular Nutrition & Food Research 63 (8):e1801097. doi: 10.1002/mnfr.201801097.
  • Xagorari, A., A. Papapetropoulos, A. Mauromatis, M. Economou, T. Fotsis, and C. Roussos. 2001. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. The Journal of Pharmacology and Experimental Therapeutics 296 (1):181–7.
  • Xavier, C. P. R., C. F. Lima, M. Rohde, and C. Pereira-Wilson. 2011. Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. Cancer Chemotherapy and Pharmacology 68 (6):1449–57.
  • Yang, G., J. Qiu, D. Wang, Y. Tao, Y. Song, H. Wang, J. Tang, X. Wang, Y. U. Sun, Z. Yang, et al. 2018. Traditional Chinese medicine curcumin sensitizes human colon cancer to radiation by altering the expression of DNA repair-related genes. Anticancer Research 38:131–6.
  • Yang, H., G. G. L. Yue, P. C. Leung, C. K. Wong, and C. B. S. Lau. 2022. A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer. Pharmacological Research 175:106031.
  • Yang, J., T. Z. Li, G. H. Xu, B. B. Luo, Y. X. Chen, and T. Zhang. 2013. Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways. Neoplasma 60 (4):364–72. doi: 10.4149/neo_2013_048.
  • Yin, T.-F., M. Wang, Y. Qing, Y.-M. Lin, and D. Wu. 2016. Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms. World Journal of Gastroenterology 22 (31):7058–68.
  • Yuan, L., M. Zhou, D. Huang, et al. 2019. Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial- mesenchymal transition via the AKT/GSK-3β/Snail signaling pathway. Molecular Medicine Reports 20:2783–95.
  • Zhang, T., P. Zheng, X. Shen, R. Shao, B. Wang, H. Shen, J. Zhang, Y. Xia, and P. Zou. 2019. Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS. Free Radical Biology & Medicine 141:93–102.
  • Zheng, X., X. Yang, J. Lin, F. Song, and Y. Shao. 2021. Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer. Phytomedicine 85:153547. doi: 10.1016/j.phymed.2021.153547.
  • Zhou, Y., J. Zhang, K. Wang, W. Han, X. Wang, M. Gao, Z. Wang, Y. Sun, H. Yan, H. Zhang, et al. 2020. Quercetin overcomes colon cancer cells resistance to chemotherapy by inhibiting solute carrier family 1, member 5 transporter. European Journal of Pharmacology 881:173185.