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The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review

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  • Akın, S., G. Donmez, M. Ozdemir, and H. A. Demirel. 2018. Does whole body vibration restore immobilization-induced suppression in AMPK activation? Turkish Journal of Sports Medicine 53 (4):174–81. doi: 10.5152/tjsm.2018.107.
  • Alagozlu, H. 2016. Gut microbiota and obesity. Turkiye Klinikleri Gastroenterohepatology - Special Topics 9 (2):28–33.
  • Altıntas, A. 2018. Vitamin d deficiency and obesity. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58:108–16.
  • Bazzano, L. A., T. Hu, K. Reynolds, L. Yao, C. Bunol, Y. Liu, C. S. Chen, M. J. Klag, P. K. Whelton, and J. He. 2014. Effects of low-carbohydrate and low-fat diets: A randomized trial. Annals of Internal Medicine 161 (5):309–18. doi: 10.7326/M14-0180.
  • Bodur, M., and A. Uçar. 2021. Palmitoleic acid and its role in certain chronic diseases: A brief review. Journal of Duzce University Health Sciences Institute 11 (1):103–7. doi: 10.33631/duzcesbed.685363
  • Britton, K. A., and C. S. Fox. 2011. Ectopic fat depots and cardiovascular disease. Circulation 124 (24):837–41. doi: 10.1161/CIRCULATIONAHA.111.077602.
  • Cetintas, I. E. 2021. Investigation of the relationship of obesity indexs and insulin resistance. Master Thesis. Faculty of Medicine, Bezmi Alem Vakıf University.
  • Chang, E., and Y. Kim. 2017. Vitamin D insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK/SIRT1 activity in obese rats. Nutrients 9 (4):338. doi: 10.3390/nu9040338.
  • Choudhury, Y., Y. Zichu, I. Ahmad, C. Nixon, I. P. Salt, and H. Y. Leung. 2014. AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience 1 (6):446–56. doi: 10.18632/oncoscience.49.
  • Curat, C. A., A. Miranville, C. Sengenès, M. Diehl, C. Tonus, R. Busse, and A. Bouloumié. 2004. From blood monocytes to adipose tissue-resident macrophages: İnduction of diapedesis by human mature adipocytes. Diabetes 53 (5):1285–92. doi: 10.2337/diabetes.53.5.1285.
  • Deliktas, Ö. 2020. The effect of AMPK modulation on cell proliferation in uveal melanoma cell lines. Thesis in Ophthalmology. Hacettepe University School of Medicine.
  • Durak, M. S., F. Akbıyık, and E. Demirpence. 2007. Obesity pathogenesis. Hacettepe Medical Journal 38:167–72.
  • Ebbeling, C. B., H. A. Feldman, G. L. Klein, J. M. W. Wong, L. Bielak, S. K. Steltz, P. K. Luoto, R. R. Wolfe, W. W. Wong, and D. S. Ludwig. 2018. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: Randomized trial. Bmj, 363:k4583. doi: 10.1136/bmj.k4583.
  • Erdal, H., and M. S. Demirtas. 2021. The effect of diet and exercise on obesity in children living in Aksaray. Osmangazi Journal of Medicine 43 (6):600–8. doi: 10.20515/otd.905673.
  • Farb, M. G., and N. Gokce. 2015. Visceral adiposopathy: A vascular perspective. Hormone Molecular Biology and Clinical İnvestigation 21 (2):125–36. doi: 10.1515/hmbci-2014-0047.
  • Faubert, B., E. E. Vincent, M. C. Poffenberger, and R. G. Jones. 2015. The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator. Cancer Letters 356 (2):165–70. doi: 10.1016/j.canlet.2014.01.018.
  • Fındık Kıyan, H., and T. Kıyan. 2019. Molecular mechanism of aging and circadian rythms. Turkiye Klinikleri Journal of Health Sciences 4 (3):400–10.
  • Finucane, O. M., C. L. Lyons, A. M. Murphy, C. M. Reynolds, R. Klinger, N. P. Healy, A. A. Cooke, R. C. Coll, L. McAllan, K. N. Nilaweera, et al. 2015. Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity. Diabetes 64 (6):2116–28. doi: 10.2337/db14-1098.
  • Foretz, M., B. Guigas, L. Bertrand, M. Pollak, and B. Viollet. 2014. Metformin: From mechanisms of action to therapies. Cell Metabolism 20 (6):953–66. doi: 10.1016/j.cmet.2014.09.018.
  • Ghosh, A., L. Gao, A. Thakur, P. M. Siu, and C. W. Lai. 2017. Role of free fatty acids in endothelial dysfunction. Journal of Biomedical Science 24 (1):1–15. doi: 10.1186/s12929-017-0357-5.
  • Gleason, C. E., D. Lu, L. A. Witters, C. B. Newgard, and M. J. Birnbaum. 2007. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. The Journal of Biological Chemistry 282 (14):10341–51. doi: 10.1074/jbc.M610631200.
  • Global Obesity Levels. 2021. Obesity rates by country (on-line). Accessed September 19, 2021. https://worldpopulationreview.com/country-rankings/obesity-rates-by-country
  • Goktas, Z., and H. T. Besler. 2015. Obesity, insulin resistance and adipokines. Journal of Nutrition and Dietetics 43 (3):251–7.
  • Gunaydın, G., and M. E. Gedik. 2018. Evaluation of the effects of AMPK modulation on cancer cell proliferation via real-time cell analysis system xCELLigence in breast and hepatocellular cancers. Bozok Medical Journal 8 (4):95–103. doi: 10.16919/bozoktip.434074
  • Guven, C., and E. Taşkın. 2015. The potential effects of HMGB-1 and AMPK on adriamycin-induced heart failure. Health Sciences Journal of Adıyaman University 1 (1):29–33.
  • Hall, K. D., and S. T. Chung. 2018. Low-carbohydrate diets for the treatment of obesity and type 2 diabetes. Current Opinion in Clinical Nutrition and Metabolic Care 21 (4):308–12. doi: 10.1097/MCO.0000000000000470.
  • Hamarat, S. 2014. The cardioprotective effect of insulin and metformin administration in acute ischemia/reperfusion in rats. Master Thesis in Physiology. Erciyes University, Institute of Health Sciences.
  • Hardie, D. G. 2008. Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Letters 582 (1):81–9. doi: 10.1016/j.febslet.2007.11.018.
  • Hardie, D. G. 2016. Regulation of AMP-activated protein kinase by natural and synthetic activators. Acta Pharmaceutica Sinica B 6 (1):1–19. doi: 10.1016/j.apsb.2015.06.002
  • Harris, M. Z., R. E. Harris, and B. C. Casto. 2014. Cyclooxygenase-2 and the inflammogenesis of breast cancer. World Journal of Clinical Oncology 5 (4):677–92. doi: 10.5306/wjco.v5.i4.677.
  • Harvie, M. N., M. Pegington, M. P. Mattson, J. Frystyk, B. Dillon, G. Evans, J. Cuzick, S. A. Jebb, B. Martin, R. G. Cutler, et al. 2011. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. International Journal of Obesity (2005) 35 (5):714–27. doi: 10.1038/ijo.2010.171.
  • Harwood, H. J.Jr. 2012. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology 63 (1):57–75. doi: 10.1016/j.neuropharm.2011.12.010.
  • Hashem, R. M., L. A. Rashed, K. M. Hassanin, M. H. Hetta, and A. O. Ahmed. 2017. Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats . Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 88:293–301. doi: 10.1016/j.biopha.2017.01.035.
  • Hijona, E., L. Hijona, J. I. Arenas, and L. Bujanda. 2010. Inflammatory mediators of hepatic steatosis. Mediators of İnflammation 2010:837419. doi: 10.1155/2010/837419.
  • Jeon, S. M. 2016. Regulation and function of AMPK in physiology and diseases. Experimental & Molecular Medicine 48 (7):e245-e245. doi: 10.1038/emm.2016.81.
  • Jung, E. H., J. H. Lee, S. C. Kim, and Y. W. Kim. 2017. AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor. European Journal of Nutrition 56 (2):635–47. doi: 10.1007/s00394-015-1107-7.
  • Kalaycı, Z., and H. Altun Kamarlı. 2021. Effects of intermittant fasting on glucose homeostasis and lipid metabolism. BANU Journal of Health Science and Research 3 (1):52–63. doi: 10.46413/boneyusbad.874087
  • Karslıoglu, D. H. 2019. Obesity type 2 diabetes and nutrition. Klinik Tıp Bilimleri 7 (3):36–43.
  • Kim, H., and H. Min. 2020. Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways. Nutrition Research and Practice 14 (4):309–21. doi: 10.4162/nrp.2020.14.4.309.
  • Kim, J., G. Yang, Y. Kim, J. Kim, and J. Ha. 2016. AMPK activators: Mechanisms of action and physiological activities. Experimental & Molecular Medicine 48 (4):e224. doi: 10.1038/emm.2016.16.
  • Kishida, K., T. Funahashi, Y. Matsuzawa, and I. Shimomura. 2012. Visceral adiposity as a target for the management of the metabolic syndrome. Annals of Medicine 44 (3):233–41. doi: 10.3109/07853890.2011.564202.
  • Kismiroğlu, C., S. Cengiz, and M. Yaman. 2020. Biochemistry of AMPK: Mechanisms of action and importance in the treatment of diabetes. European Journal of Science and Technology 18:162–70. doi: 10.31590/ejosat.676335.
  • Koay, A., B. Woodcroft, E. J. Petrie, H. Yue, S. Emanuelle, M. Bieri, M. F. Bailey, M. Hargreaves, J.-T. Park, K.-H. Park, et al. 2010. AMPK beta subunits display isoform specific affinities for carbohydrates. FEBS Letters 584 (15):3499–503. doi: 10.1016/j.febslet.2010.07.015.
  • Kodiha, M, and U. Stochaj. 2011. Targeting AMPK for therapeutic intervention in type 2 diabetes. Rijeka, Croatia: InTech.
  • Lan, F., J. M. Cacicedo, N. Ruderman, and Y. Ido. 2008. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1 possible role in AMP-activated protein kinase activation. The Journal of Biological Chemistry 283 (41):27628–35. doi: 10.1074/jbc.M805711200.
  • Lee, H. W., H. W. Ryu, M.-G. Kang, D. Park, H. Lee, H. M. Shin, S.-R. Oh, and H. Kim. 2017. Potent inhibition of monoamine oxidase A by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi. International Journal of Biological Macromolecules 97:598–605. doi: 10.1016/j.ijbiomac.2017.01.080.
  • Liao, Z. Y., J. L. Chen, M. H. Xiao, Y. Sun, Y. X. Zhao, D. Pu, A. K. Lv, M. L. Wang, J. Zhou, S. Y. Zhu, et al. 2017. The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/SIRT1 pathway. Experimental Gerontology 98:177–83. doi: 10.1016/j.exger.2017.08.032.
  • Li, W., S. M. Saud, M. R. Young, G. Chen, and B. Hua. 2015. Targeting AMPK for cancer prevention and treatment. Oncotarget 6 (10):7365–78. doi: 10.18632/oncotarget.3629.
  • Li, S., Y. Zhang, Y. Sun, G. Zhang, J. Bai, J. Guo, X. Su, H. Du, X. Cao, J. Yang, et al. 2019. Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK. Nutrition & Diabetes 9 (1):1–10. doi: 10.1038/s41387-019-0095-8.
  • Lyons, C. L., and H. M. Roche. 2018. Nutritional modulation of AMPK-impact upon metabolic-inflammation. International Journal of Molecular Sciences 19 (10):3092. doi: 10.3390/ijms19103092.
  • Mathieu, P., M. C. Boulanger, and J. P. Despres. 2014. Ectopic visceral fat: A clinical and molecular perspective on the cardiometabolic risk. Reviews in Endocrine & Metabolic Disorders 15 (4):289–98. doi: 10.1007/s11154-014-9299-3
  • McBride, A., S. Ghilagaber, A. Nikolaev, and D. G. Hardie. 2009. The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metabolism 9 (1):23–34. doi: 10.1016/j.cmet.2008.11.008.
  • Meckling, K. A., C. O’Sullivan, and D. Saari. 2004. Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women. The Journal of Clinical Endocrinology and Metabolism 89 (6):2717–23. doi: 10.1210/jc.2003-031606.
  • Mihaylova, M. M., and R. J. Shaw. 2011. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biology 13 (9):1016–23. doi: 10.1038/ncb2329.
  • Mims, N. B. 2014. Yo-yo Syndrome and affecting factors. Master Thesis in Nutrition and Dietetics. Istanbul Bilim Universıty Institute of Health Sciences.
  • Minokoshi, Y., Y. B. Kim, O. D. Peroni, L. G. D. Fryer, C. Müller, D. Carling, and B. B. Kahn. 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (6869):339–43. doi: 10.1038/415339a.
  • Moon, J. S., K. Nakahira, and A. M. Choi. 2015. Fatty acid synthesis and NLRP3-inflammasome. Oncotarget 6 (26):21765–6. doi: 10.18632/oncotarget.4781.
  • Naimi, M., T. Tsakiridis, T. C. Stamatatos, D. I. Alexandropoulos, and E. Tsiani. 2015. Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation. Applied Physiology, Nutrition, and Metabolism 40 (4):407–13. doi: 10.1139/apnm-2014-0430.
  • Nebiler, E. 2019. The idendification of global protein expression profile of pc3 prostate cancer and pnt1a prostate epithelial cells following anti-obesity drug orlistat treatment through 2d-dige method. Master Thesis in Molecular Biology and Genetics. Istanbul Kultur University, Graduate Education Institute.
  • Neeha, V. S., and P. Kinth. 2013. Nutrigenomics research: A review. Journal of Food Science and Technology 50 (3):415–28. doi: 10.1007/s13197-012-0775-z.
  • O’Neill, H. M. 2013. AMPK and exercise: Glucose uptake and insulin sensitivity. Diabetes & Metabolism Journal 37 (1):1–21. doi: 10.4093/dmj.2013.37.1.1.
  • Ongan, D., C. Ayer, E. Cankaya, Z. Ciftci, and A. N. Songur Bozdag. 2021. Opinions of dietitians about factors affecting ındividual nutrition counseling and job satisfaction. Journal of Adnan Menderes University Health Sciences Faculty 5 (2):315–32. doi: 10.46237/amusbfd.890247.
  • Orek, D., Y. Sule, and D. Mertoglu. 2020. The effects of high fructose corn syrup consumption on human health. Van Medical Journal 27 (3):371–82. doi: 10.5505/vtd.2020.19981
  • Pekcan, A. G. 2020. Health and nutrition economics: Dietitian and cost-benefit analysis. Journal of Nutrition and Dietetics 48 (3):1–7. doi: 10.33076/2020.BDD.1435.
  • Pekkolay, Z. 2018. Obesity pathogenesis. Fırat Tıp Dergisi 23:5–8.
  • Pires, R. C., E. E. Souza, E. C. Vanzela, E. A. Ribeiro, J. C. Silva-Santos, E. M. Carneiro, A. C. Boschero, and M. E. C. Amaral. 2014. Short-term calorie restriction improves glucose homeostasis in old rats: İnvolvement of AMPK. Applied Physiology, Nutrition, and Metabolism 39 (8):895–901. doi: 10.1139/apnm-2013-0520.
  • Pontzer, H., Y. Yamada, H. Sagayama, P. N. Ainslie, L. F. Andersen, L. J. Anderson, L. Arab, I. Baddou, K. Bedu-Addo, E. E. Blaak, et al. 2021. Daily energy expenditure through the human life course. Science (New York, N.Y.) 373 (6556):808–12. doi: 10.1126/science.abe5017.
  • Rajpal, A., and F. Ismail‐Beigi. 2020. Intermittent fasting and ‘metabolic switch’: Effects on metabolic syndrome, prediabetes and type 2 diabetes. Diabetes, Obesity & Metabolism 22 (9):1496–510. doi: 10.1111/dom.14080.
  • Rana, S., E. C. Blowers, and A. Natarajan. 2015. Small molecule adenosine 5′-monophosphate activated protein kinase (AMPK) modulators and human diseases. Journal of Medicinal Chemistry 58 (1):2–29. doi: 10.1021/jm401994c.
  • Ruderman, N., and M. Prentki. 2004. AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome. Nature Reviews. Drug Discovery 3 (4):340–51. doi: 10.1038/nrd1344.
  • Saha, A. K., X. J. Xu, T. W. Balon, A. Brandon, E. W. Kraegen, and N. B. Ruderman. 2011. Insulin resistance due to nutrient excess: İs it a consequence of AMPK downregulation? Cell Cycle (Georgetown, Tex.) 10 (20):3447–51. doi: 10.4161/cc.10.20.17886.
  • Sahin, C. E., M. A. Sezerol, and M. Atak. 2021. Assessments of healthy diet and obesity services on primary health care centers in turkey. Anatolian Clinic Journal of Medical Science 26 (1):60–9. doi: 10.21673/anadoluklin.743525.
  • Salminen, A., and K. Kaarniranta. 2012. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Research Reviews 11 (2):230–41. doi: 10.1016/j.arr.2011.12.005.
  • Sandalcı, U., and G. Tuncer. 2020. An Evaluation of direct and indirect costs of obesity. Journal of Aksaray University Faculty of Economics and Administrative Sciences 12 (2):29–44.
  • Song, Z., I. Deaciuc, Z. Zhou, M. Song, T. Chen, D. Hill, and C. J. McClain. 2007. Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. American Journal of Physiology-Gastrointestinal and Liver 293 (4):894–902. doi: 10.1152/ajpgi.00133.2007
  • Sözlü, S., and N. Şanlıer. 2017. Circadian rythm, health and nutrition relationship: Rewiev. Turkiye Klinikleri Journal of Health Sciences 2 (2):100–9. doi: 10.5336/healthsci.2015-48902.
  • Strychar, I. 2006. Diet in the management of weight loss. Canadian Medical Association Journal 174 (1):56–63. doi: 10.1503/cmaj.045037.
  • Summermatter, S., and C. Handschin. 2012. PGC-1α and exercise in the control of body weight. International Journal of Obesity (2005) 36 (11):1428–35. doi: 10.1038/ijo.2012.12.
  • Tam, A., and B. Cakır. 2020. Approach of obesity in primary health care. Ankara Medical Journal 12 (1):37–41.
  • Tamer, F. 2017. The effects of dietary fatty acids and fructose on some inflammatory mediators and fatty acid biosynthesis in mice. Doctor of Philosophy Thesis in Nutrition and Dietetics. Hacettepe University, Institute of Health Sciences.
  • Tanyıldız, S. N., H. Yıldırım, H. Ugur, and M. Yaman. 2021. AMPK’s natural activators and relationships with diseases. The European Journal of Science and Technology 21:389–401. doi: 10.31590/ejosat.762959
  • Tas, S. K., and S. Irtegun. 2015. The long-term effects of nutrigenetics on health. Turkiye Klinikleri Nutrition and Dietetics - Special Topics 1 (3):31–8.
  • Tchernof, A., and J. P. Despres. 2013. Pathophysiology of human visceral obesity: An update. Physiological Reviews 93 (1):359–404. doi: 10.1152/physrev.00033.2011.
  • Turkish Society of Endocrinology and Metabolism. 2018. Obesity diagnosis and treatment guide. Ankara, Turkey. http://www.temd.org.tr/admin/uploads/tbl_gruplar/20180525144116-2018-05-25tbl_gruplar144108.pdf
  • Wei, C. C., K. Wu, Y. Gao, L. H. Zhang, D. D. Li, and Z. Luo. 2017. Magnesium reduces hepatic lipid accumulation in yellow catfish (Pelteobagrus fulvidraco) and modulates lipogenesis and lipolysis via PPARA, JAK-STAT, and AMPK pathways in hepatocytes. The Journal of Nutrition 147 (6):1070–8. doi: 10.3945/jn.116.245852.
  • Yaman, M., C. Kismiroglu, H. Ugur, I. Belli, and B. Ozgur. 2020. Biochemical development of insulin resistance due to excess nutrition and the function of AMP-activated protein kinase (AMPK). The European Journal of Science and Technology 20:67–76. doi: 10.31590/ejosat.746132.
  • Yang, T. H., H. T. Yao, and M. T. Chiang. 2017. Red algae (Gelidium amansii) hot-water extract ameliorates lipid metabolism in hamsters fed a high-fat diet. Journal of Food and Drug Analysis 25 (4):931–8. doi: 10.1016/j.jfda.2016.12.008.
  • Yeo, W. K., S. J. Lessard, Z. P. Chen, A. P. Garnham, L. M. Burke, D. A. Rivas, B. E. Kemp, and J. A. Hawley. 2008. Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology 105 (5):1519–26. doi: 10.1152/japplphysiol.90540.2008.
  • Zhang, H., Y. Li, J. Hu, W.-J. Shen, M. Singh, X. Hou, A. Bittner, S. Bittner, Y. Cortez, J. Tabassum, et al. 2015. Effect of creosote bush-derived NDGA on expression of genes involved in lipid metabolism in liver of high-fructose fed rats: Relevance to NDGA amelioration of hypertriglyceridemia and hepatic steatosis. PloS One 10 (9):e0138203. doi: 10.1371/journal.pone.0138203.
  • Zhang, Y., T. Zhang, C. M. Cao, and R. P. Xiao. 2012. mTOR: Good, bad, or ugly? Cardiovascular Research 95 (3):261–2. doi: 10.1093/cvr/cvs201.

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