Short-chain fatty acid: An updated review on signaling, metabolism, and therapeutic effects

References

• Abumrad, N. A, and N. O. Davidson. 2012. Role of the gut in lipid homeostasis. Physiological Reviews 92 (3):1061–85. doi: 10.1152/physrev.00019.2011.
   PubMed Web of Science ®Google Scholar
• Ahmad, S. Y., J. Friel, and D. Mackay. 2020. The effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the gut microbiome in healthy adults: Secondary outcomes of a randomized double-blinded crossover clinical trial. Nutrients 12 (11):3408. doi: 10.3390/nu12113408.
   PubMed Web of Science ®Google Scholar
• Aich, U., M. A. Meledeo, S. G. Sampathkumar, J. Fu, M. B. Jones, C. A. Weier, S. Y. Chung, B. C. Tang, M. Yang, J. Hanes, et al. 2010. Development of delivery methods for carbohydrate-based drugs: Controlled release of biologically-active short chain fatty acid-hexosamine analogs. Glycoconjugate Journal 27 (4):445–59. doi: 10.1007/s10719-010-9292-3.
   PubMed Web of Science ®Google Scholar
• Al-Harbi, N. O., A. Nadeem, S. F. Ahmad, M. R. Alotaibi, A. F. AlAsmari, W. A. Alanazi, M. M. Al Harbi, A. M. El-Sherbeeny, and K. E. Ibrahim. 2018. Short chain fatty acid, acetate ameliorates sepsis-induced acute kidney injury by inhibition of NADPH oxidase signalling in T cells. International Immunopharmacology 58:24–31. doi: 10.1016/j.intimp.2018.02.023.
   PubMed Web of Science ®Google Scholar
• Ali, I., C. Li, L. Li, M. Kuang, M. Shafiq, Y. Wang, M. Yang, and G. Wang. 2021. Effect of acetate, β-hydroxybutyrate and their interaction on lipogenic gene expression, triglyceride contents and lipid droplet formation in dairy cow mammary epithelial cells. In Vitro Cellular & Developmental Biology. Animal 57 (1):66–75. doi: 10.1007/s11626-020-00538-2.
   PubMed Web of Science ®Google Scholar
• Aoyama, M., J. Kotani, and M. Usami. 2010. Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. Nutrition (Burbank, Los Angeles County, Calif.) 26 (6):653–61. doi: 10.1016/j.nut.2009.07.006.
   PubMed Web of Science ®Google Scholar
• Bachem, A., C. Makhlouf, K. J. Binger, D. P. de Souza, D. Tull, K. Hochheiser, P. G. Whitney, D. Fernandez-Ruiz, S. Dähling, W. Kastenmüller, et al. 2019. Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells. Immunity 51 (2):285–97.e5. doi: 10.1016/j.immuni.2019.06.002.
   PubMed Web of Science ®Google Scholar
• Ball, D. R., B. Rowlands, M. S. Dodd, L. Le Page, V. Ball, C. A. Carr, K. Clarke, and D. J. Tyler. 2014. Hyperpolarized butyrate: A metabolic probe of short chain fatty acid metabolism in the heart. Magnetic Resonance in Medicine 71 (5):1663–9. doi: 10.1002/mrm.24849.
   PubMed Web of Science ®Google Scholar
• Bartolomaeus, H., A. Balogh, M. Yakoub, S. Homann, L. Markó, S. Höges, D. Tsvetkov, A. Krannich, S. Wundersitz, E. G. Avery, et al. 2019. Short-chain fatty acid propionate protects from hypertensive cardiovascular damage. Circulation 139 (11):1407–21. doi: 10.1161/CIRCULATIONAHA.118.036652.
   PubMed Web of Science ®Google Scholar
• Battson, M. L., D. M. Lee, L. C. Li Puma, K. E. Ecton, K. N. Thomas, H. P. Febvre, A. J. Chicco, T. L. Weir, and C. L. Gentile. 2019. Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity. American Journal of Physiology. Heart and Circulatory Physiology 317 (6):H1210–H1220. doi: 10.1152/ajpheart.00346.2019.
   PubMed Web of Science ®Google Scholar
• Bellahcene, M., J. F. O’Dowd, E. T. Wargent, M. S. Zaibi, D. C. Hislop, R. A. Ngala, D. M. Smith, M. A. Cawthorne, C. J. Stocker, J. R. S. Arch, et al. 2013. Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. The British Journal of Nutrition 109 (10):1755–64. doi: 10.1017/S0007114512003923.
   PubMed Web of Science ®Google Scholar
• Bian, X., L. Yang, W. Wu, L. Lv, X. Jiang, Q. Wang, J. Wu, Y. Li, J. Ye, D. Fang, et al. 2020. Pediococcuspentosaceus LI05 alleviates DSS-induced colitis by modulating immunological profiles, the gut microbiota and short-chain fatty acid levels in a mouse model. Microbial Biotechnology 13 (4):1228–44. doi: 10.1111/1751-7915.13583.
   PubMed Web of Science ®Google Scholar
• Bier, A., T. Braun, R. Khasbab, A. Di Segni, E. Grossman, Y. Haberman, and A. Leibowitz. 2018. A high salt diet modulates the gut microbiota and short chain fatty acids production in a salt-sensitive hypertension rat model. Nutrients 10 (9):1154. doi: 10.3390/nu10091154.
   PubMed Web of Science ®Google Scholar
• Birkeland, E., S. Gharagozlian, K. I. Birkeland, J. Valeur, I. Måge, I. Rud, and A. M. Aas. 2020. Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: A randomised controlled trial. European Journal of Nutrition 59 (7):3325–38. doi: 10.1007/s00394-020-02282-5.
   PubMed Web of Science ®Google Scholar
• Bloemen, J. G., S. W. Olde Damink, K. Venema, W. A. Buurman, R. Jalan, and C. H. Dejong. 2010. Short chain fatty acids exchange: Is the cirrhotic, dysfunctional liver still able to clear them? Clinical Nutrition (Edinburgh, Scotland) 29 (3):365–9. doi: 10.1016/j.clnu.2009.10.002.
   PubMed Web of Science ®Google Scholar
• Bojović, K., Ð. I. Ignjatović, S. SokovićBajić, et al. 2020. Gut microbiota dysbiosis associated with altered production of short chain fatty acids in children with neurodevelopmental disorders. Frontiers in Cellular and Infection Microbiology. 10:223. doi: 10.3389/fcimb.2020.00223.
   PubMed Web of Science ®Google Scholar
• Bolduc, J. F., L. Hany, C. Barat, M. Ouellet, and M. J. Tremblay. 2017. Epigenetic metabolite acetate inhibits class I/II histone deacetylases, promotes histone acetylation, and increases HIV-1 integration in CD4+ T cells. Journal of Virology 91 (16):e01943–16. doi: 10.1128/JVI.01943-16.
   PubMed Web of Science ®Google Scholar
• Brody, L. P., M. Sahuri-Arisoylu, J. R. Parkinson, H. G. Parkes, P. W. So, N. Hajji, E. L. Thomas, G. S. Frost, A. D. Miller, and J. D. Bell. 2017. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine 12:6677–85. doi: 10.2147/IJN.S135968.
   PubMed Web of Science ®Google Scholar
• Calder, P. C. 2015. Functional roles of fatty acids and their effects on human health. JPEN. Journal of Parenteral and Enteral Nutrition 39 (1 Suppl):18S–32S. doi: 10.1177/0148607115595980.
   PubMedGoogle Scholar
• Calderón-Pérez, L., M. J. Gosalbes, S. Yuste, R. M. Valls, A. Pedret, E. Llauradó, N. Jimenez-Hernandez, A. Artacho, L. Pla-Pagà, J. Companys, et al. 2020. Gut metagenomic and short chain fatty acids signature in hypertension: A cross-sectional study. Scientific Reports 10 (1):6436. doi: 10.1038/s41598-020-63475-w.
   PubMed Web of Science ®Google Scholar
• Canfora, E. E., J. W. Jocken, and E. E. Blaak. 2015. Short-chain fatty acids in control of body weight and insulin sensitivity. Nature Reviews. Endocrinology 11 (10):577–91. doi: 10.1038/nrendo.2015.128.
   PubMed Web of Science ®Google Scholar
• Canfora, E. E., C. M. van der Beek, J. W. E. Jocken, G. H. Goossens, J. J. Holst, S. W. M. Olde Damink, K. Lenaerts, C. H. C. Dejong, and E. E. Blaak. 2017. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: A randomized crossover trial. Scientific Reports 7 (1):2360. doi: 10.1038/s41598-017-02546-x.
   PubMedGoogle Scholar
• Carley, A. N., S. K. Maurya, M. Fasano, Y. Wang, C. H. Selzman, S. G. Drakos, and E. D. Lewandowski. 2021. Short-chain fatty acids outpace ketone oxidation in the failing heart. Circulation 143 (18):1797–808. doi: 10.1161/CIRCULATIONAHA.120.052671.
   PubMed Web of Science ®Google Scholar
• Castro, P. R., L. F. F. Bittencourt, S. Larochelle, S. P. Andrade, C. R. Mackay, M. Slevin, V. J. Moulin, and L. S. Barcelos. 2021. GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling. American Journal of Physiology. Heart and Circulatory Physiology 320 (3):H1066–H1079. doi: 10.1152/ajpheart.00515.2019.
   PubMed Web of Science ®Google Scholar
• Chambers, E. S., D. J. Morrison, and G. Frost. 2015. Control of appetite and energy intake by SCFA: What are the potential underlying mechanisms? The Proceedings of the Nutrition Society 74 (3):328–36. doi: 10.1017/S0029665114001657.
   PubMed Web of Science ®Google Scholar
• Chang, P. V., L. Hao, S. Offermanns, and R. Medzhitov. 2014. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proceedings of the National Academy of Sciences of the United States of America 111 (6):2247–52. doi: 10.1073/pnas.1322269111.
   PubMed Web of Science ®Google Scholar
• Chen, G., X. Ran, B. Li, Y. Li, D. He, B. Huang, S. Fu, J. Liu, and W. Wang. 2018. Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model. EBioMedicine 30:317–25. doi: 10.1016/j.ebiom.2018.03.030.
   PubMed Web of Science ®Google Scholar
• Chen, J., F. M. Ghazawi, W. Bakkar, and Q. Li. 2006. Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B. Molecular Cancer 5:71. 5:doi: 10.1186/1476-4598-5-71.
   PubMed Web of Science ®Google Scholar
• Chen, R., Y. Xu, P. Wu, H. Zhou, Y. Lasanajak, Y. Fang, L. Tang, L. Ye, X. Li, Z. Cai, et al. 2019. Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota. Pharmacological Research 148:104403. doi: 10.1016/j.phrs.2019.104403.
   PubMed Web of Science ®Google Scholar
• Cho, T., C. Lee, N. Lee, Y. R. Hong, and J. Koo. 2019. Small-chain fatty acid activates astrocytic odorant receptor Olfr920. Biochemical and Biophysical Research Communications 510 (3):383–7. doi: 10.1016/j.bbrc.2019.01.106.
   PubMed Web of Science ®Google Scholar
• Chriett, S., O. Zerzaihi, H. Vidal, and L. Pirola. 2017. The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1. Molecular and Cellular Endocrinology 439:224–32. doi: 10.1016/j.mce.2016.09.006.
   PubMed Web of Science ®Google Scholar
• Cyr, A. R., and F. E. Domann. 2011. The redox basis of epigenetic modifications: From mechanisms to functional consequences. Antioxidants & Redox Signaling 15 (2):551–89. doi: 10.1089/ars.2010.3492.
   PubMed Web of Science ®Google Scholar
• Dangana, E. O., T. E. Omolekulo, E. D. Areola, K. S. Olaniyi, A. O. Soladoye, and L. A. Olatunji. 2020. Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity. Chemico-Biological Interactions 316:108929. doi: 10.1016/j.cbi.2019.108929.
   PubMed Web of Science ®Google Scholar
• de la Cuesta-Zuluaga, J., N. T. Mueller, R. Álvarez-Quintero, E. P. Velásquez-Mejía, J. A. Sierra, V. Corrales-Agudelo, J. A. Carmona, J. M. Abad, and J. S. Escobar. 2018. Higher fecal short-chain fatty acid levels are associated with gut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors. Nutrients 11 (1):51. doi: 10.3390/nu11010051.
   PubMed Web of Science ®Google Scholar
• den Besten, G., A. Bleeker, A. Gerding, K. van Eunen, R. Havinga, T. H. van Dijk, M. H. Oosterveer, J. W. Jonker, A. K. Groen, D. J. Reijngoud, et al. 2015a. Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64 (7):2398–408. doi: 10.2337/db14-1213.
   PubMed Web of Science ®Google Scholar
• den Besten, G., A. Gerding, T. H. van Dijk, J. Ciapaite, A. Bleeker, K. van Eunen, R. Havinga, A. K. Groen, D. J. Reijngoud, and B. M. Bakker. 2015b. Protection against the metabolic syndrome by guar gum-derived short-chain fatty acids depends on peroxisome proliferator-activated receptor γ and glucagon-like peptide-1. PLoS One 10 (8):e0136364. doi: 10.1371/journal.pone.0136364.
   PubMed Web of Science ®Google Scholar
• den Besten, G., K. van Eunen, A. K. Groen, K. Venema, D. J. Reijngoud, and B. M. Bakker. 2013. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research 54 (9):2325–40. doi: 10.1194/jlr.R036012.
   PubMed Web of Science ®Google Scholar
• Deng, M., F. Qu, L. Chen, C. Liu, M. Zhang, F. Ren, H. Guo, H. Zhang, S. Ge, C. Wu, et al. 2020. SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD. The Journal of Endocrinology 245 (3):425–37. doi: 10.1530/JOE-20-0018.
   PubMed Web of Science ®Google Scholar
• Dou, X., N. Gao, J. Lan, J. Han, Y. Yang, and A. Shan. 2020. TLR2/EGFR are two sensors for pBD3 and pEP2C induction by sodium butyrate independent of HDAC inhibition. Journal of Agricultural and Food Chemistry 68 (2):512–22. doi: 10.1021/acs.jafc.9b06569.
   PubMed Web of Science ®Google Scholar
• Drozdowski, L. A., W. T. Dixon, M. I. McBurney, and A. B. Thomson. 2002. Short-chain fatty acids and total parenteral nutrition affect intestinal gene expression. JPEN. Journal of Parenteral and Enteral Nutrition 26 (3):145–50. doi: 10.1177/0148607102026003145.
   PubMed Web of Science ®Google Scholar
• D’Souza, W. N., J. Douangpanya, S. Mu, P. Jaeckel, M. Zhang, J. R. Maxwell, J. B. Rottman, K. Labitzke, A. Willee, H. Beckmann, et al. 2017. Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses. PLoS One 12 (7):e0180190. doi: 10.1371/journal.pone.0180190.
   PubMed Web of Science ®Google Scholar
• Du, Y., G. Tang, and W. Yuan. 2020. Suppression of HDAC2 by sodium butyrate alleviates apoptosis of kidney cells in db/db mice and HG-induced NRK-52E cells. International Journal of Molecular Medicine 45 (1):210–22. doi: 10.3892/ijmm.2019.4397.
   PubMed Web of Science ®Google Scholar
• El Hage, R., E. Hernandez-Sanabria, M. Calatayud Arroyo, and T. Van de Wiele. 2020. Supplementation of a propionate-producing consortium improves markers of insulin resistance in an in vitro model of gut-liveraxis. American Journal of Physiology. Endocrinology and Metabolism 318 (5):E742–E749. doi: 10.1152/ajpendo.00523.2019.
   PubMed Web of Science ®Google Scholar
• Erdbrügger, P., and F. Fröhlich. 2020. The role of very long chain fatty acids in yeast physiology and human diseases. Biological Chemistry 402 (1):25–38. doi: 10.1515/hsz-2020-0234.
   PubMed Web of Science ®Google Scholar
• Erny, D., A. L. Hrabě de Angelis, D. Jaitin, P. Wieghofer, O. Staszewski, E. David, H. Keren-Shaul, T. Mahlakoiv, K. Jakobshagen, T. Buch, et al. 2015. Host microbiota constantly control maturation and function of microglia in the CNS. Nature Neuroscience 18 (7):965–77. doi: 10.1038/nn.4030.
   PubMed Web of Science ®Google Scholar
• Fechner, A., M. Kiehntopf, and G. Jahreis. 2014. The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults. The Journal of Nutrition 144 (5):599–607. doi: 10.3945/jn.113.186858.
   PubMed Web of Science ®Google Scholar
• Felizardo, R. J. F., D. C. de Almeida, R. L. Pereira, I. K. M. Watanabe, N. T. S. Doimo, W. R. Ribeiro, M. A. Cenedeze, M. I. Hiyane, M. T. Amano, T. T. Braga, et al. 2019. Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms. FASEB Journal 33 (11):11894–908. doi: 10.1096/fj.201901080R.
   PubMed Web of Science ®Google Scholar
• Ferrer-Picón, E., I. Dotti, A. M. Corraliza, A. Mayorgas, M. Esteller, J. C. Perales, E. Ricart, M. C. Masamunt, A. Carrasco, E. Tristán, et al. 2020. Intestinal inflammation modulates the epithelial response to butyrate in patients with inflammatory bowel disease. Inflammatory Bowel Diseases 26 (1):43–55. doi: 10.1093/ibd/izz119.
   PubMed Web of Science ®Google Scholar
• Flint, H. J., S. H. Duncan, K. P. Scott, and P. Louis. 2015. Links between diet, gut microbiota composition and gut metabolism. The Proceedings of the Nutrition Society 74 (1):13–22. doi: 10.1017/S0029665114001463.
   PubMed Web of Science ®Google Scholar
• Flock, T., A. S. Hauser, N. Lund, D. E. Gloriam, S. Balaji, and M. M. Babu. 2017. Selectivity determinants of GPCR-G-protein binding. Nature 545 (7654):317–22. doi: 10.1038/nature22070.
   PubMed Web of Science ®Google Scholar
• Freeland, K. R., and T. M. Wolever. 2010. Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha. British Journal of Nutrition 103 (3):460–6. doi: 10.1017/S0007114509991863.
   PubMed Web of Science ®Google Scholar
• Frost, G., M. L. Sleeth, M. Sahuri-Arisoylu, B. Lizarbe, S. Cerdan, L. Brody, J. Anastasovska, S. Ghourab, M. Hankir, S. Zhang, et al. 2014. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nature Communications 5:3611. doi: 10.1038/ncomms4611.
   PubMed Web of Science ®Google Scholar
• Fuller, M., M. Priyadarshini, S. M. Gibbons, A. R. Angueira, M. Brodsky, M. G. Hayes, P. Kovatcheva-Datchary, F. Bäckhed, J. A. Gilbert, W. L. Lowe, Jr, et al. 2015. The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis. American Journal of Physiology. Endocrinology and Metabolism 309 (10):E840–E851. doi: 10.1152/ajpendo.00171.2015.
   PubMed Web of Science ®Google Scholar
• Geirnaert, A., M. Calatayud, C. Grootaert, D. Laukens, S. Devriese, G. Smagghe, M. De Vos, N. Boon, and T. Van de Wiele. 2017. Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrateproduction and enhanced intestinal epithelial barrier integrity. Scientific Reports 7 (1):11450. doi: 10.1038/s41598-017-11734-8.
   PubMedGoogle Scholar
• Glick, N. R., and M. H. Fischer. 2013. The role of essential fatty acids in human health. Journal of Evidence-Based Complementary & Alternative Medicine 18 (4):268–89. doi: 10.1177/2156587213488788.
   Google Scholar
• Granado-Serrano, A. B., M. Martín-Garí, V. Sánchez, M. Riart Solans, R. Berdún, I. A. Ludwig, L. Rubió, E. Vilaprinyó, M. Portero-Otín, J. C. E. Serrano, et al. 2019. Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia. Scientific Reports 9 (1):1772. doi: 10.1038/s41598-019-38874-3.
   PubMed Web of Science ®Google Scholar
• Guo, W.-L., J.-B. Guo, B.-Y. Liu, J.-Q. Lu, M. Chen, B. Liu, W.-D. Bai, P.-F. Rao, L. Ni, X.-C. Lv, et al. 2020. Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet. Food & Function 11 (8):6818–33. doi: 10.1039/d0fo00436g.
   PubMed Web of Science ®Google Scholar
• Hald, S., A. G. Schioldan, M. E. Moore, A. Dige, H. N. Laerke, J. Agnholt, K. E. Bach Knudsen, K. Hermansen, M. L. Marco, S. Gregersen, et al. 2016. Effects of arabinoxylan and resistant starch on intestinal microbiota and short-chain fatty acids in subjects with metabolic syndrome: A randomised crossover study. PLoS One 11 (7):e0159223. doi: 10.1371/journal.pone.0159223.
   PubMed Web of Science ®Google Scholar
• Han, A., N. Bennett, B. Ahmed, J. Whelan, and D. R. Donohoe. 2018. Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases. Oncotarget 9 (43):27280–92. doi: 10.18632/oncotarget.25546.
   PubMedGoogle Scholar
• He, J., P. Zhang, L. Shen, L. Niu, Y. Tan, L. Chen, Y. Zhao, L. Bai, X. Hao, X. Li, et al. 2020. Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism. International Journal of Molecular Sciences 21 (17):6356. doi: 10.3390/ijms21176356.
   PubMed Web of Science ®Google Scholar
• Hernández, M. A. G., E. E. Canfora, J. W. E. Jocken, and E. E. Blaak. 2019. The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients 11 (8):1943. doi: 10.3390/nu11081943.
   PubMed Web of Science ®Google Scholar
• Higashimura, Y., Y. Naito, T. Takagi, K. Uchiyama, K. Mizushima, and T. Yoshikawa. 2015. Propionate promotes fatty acid oxidation through the up-regulation of peroxisome proliferator-activated receptor α in intestinal epithelial cells. Journal of Nutritional Science and Vitaminology 61 (6):511–5. doi: 10.3177/jnsv.61.511.
   PubMed Web of Science ®Google Scholar
• Høgh, R. I., S. H. Møller, S. D. Jepsen, M. Mellergaard, A. Lund, M. Pejtersen, E. Fitzner, L. Andresen, and S. Skov. 2020. Metabolism of short-chain fatty acid propionate induces surface expression of NKG2D ligands on cancer cells. FASEB Journal 34 (11):15531–46. doi: 10.1096/fj.202000162R.
   PubMed Web of Science ®Google Scholar
• Holota, Y., T. Dovbynchuk, I. Kaji, I. Vareniuk, N. Dzyubenko, T. Chervinska, L. Zakordonets, V. Stetska, L. Ostapchenko, T. Serhiychuk, et al. 2019. The long-term consequences of antibiotic therapy: Role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity. PLoS One 14 (8):e0220642. doi: 10.1371/journal.pone.0220642.
   PubMed Web of Science ®Google Scholar
• Hu, J., S. Lin, B. Zheng, and P. C. K. Cheung. 2018. Short-chain fatty acids in control of energy metabolism. Critical Reviews in Food Science and Nutrition 58 (8):1243–9. doi: 10.1080/10408398.2016.1245650.
   PubMed Web of Science ®Google Scholar
• Hu, L., S. Zhu, X. Peng, K. Li, W. Peng, Y. Zhong, C. Kang, X. Cao, Z. Liu, and B. Zhao. 2020. High salt elicits brain inflammation and cognitive dysfunction, accompanied by alternations in the gut microbiota and decreased SCFA production. Journal of Alzheimer’s Disease: JAD 77 (2):629–40. doi: 10.3233/JAD-200035.
   PubMed Web of Science ®Google Scholar
• Hu, M., D. Eviston, P. Hsu, E. Mariño, A. Chidgey, B. Santner-Nanan, K. Wong, J. L. Richards, Y. A. Yap, F. Collier, et al. 2019. Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia. Nature Communications 10 (1):3031. doi: 10.1038/s41467-019-10703-1.
   PubMedGoogle Scholar
• Hu, S., R. Kuwabara, B. J. de Haan, A. M. Smink, and P. de Vos. 2020. Acetate and butyrate improve β-cell metabolism and mitochondrial respiration under oxidative stress. International Journal of Molecular Sciences 21 (4):1542. doi: 10.3390/ijms21041542.
   PubMed Web of Science ®Google Scholar
• Huang, W., Y. Man, C. Gao, L. Zhou, J. Gu, H. Xu, Q. Wan, Y. Long, L. Chai, Y. Xu, et al. 2020. Short-chain fatty acids ameliorate diabetic nephropathy via GPR43-mediated inhibition of oxidative stress and NF-κB signalling. Oxidative Medicine and Cellular Longevity 2020:4074832. doi: 10.1155/2020/4074832.
   PubMed Web of Science ®Google Scholar
• Huart, J., J. Leenders, B. Taminiau, J. Descy, A. Saint-Remy, G. Daube, J.-M. Krzesinski, P. Melin, P. de Tullio, F. Jouret, et al. 2019. Gut microbiota and fecal levels of short-chain fatty acids differ upon 24-hour blood pressure levels in men. Hypertension (Dallas, Tex. : 1979) 74 (4):1005–13. doi: 10.1161/HYPERTENSIONAHA.118.12588.
   PubMed Web of Science ®Google Scholar
• Hung, T. V, and T. Suzuki. 2018. Dietary fermentable fibers attenuate chronic kidney disease in mice by protecting the intestinal barrier. The Journal of Nutrition 148 (4):552–61. doi: 10.1093/jn/nxy008.
   PubMed Web of Science ®Google Scholar
• Hustoft, T. N., T. Hausken, S. O. Ystad, J. Valeur, K. Brokstad, J. G. Hatlebakk, and G. A. Lied. 2017. Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology & Motility 29 (4):e12969. doi: 10.1111/nmo.12969.
   Web of Science ®Google Scholar
• Iannucci, L. F., J. Sun, B. K. Singh, J. Zhou, V. A. Kaddai, A. Lanni, P. M. Yen, and R. A. Sinha. 2016. Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. Biochemical and Biophysical Research Communications 480 (3):461–7. doi: 10.1016/j.bbrc.2016.10.072.
   PubMed Web of Science ®Google Scholar
• Imoto, Y., A. Kato, T. Takabayashi, M. Sakashita, J. E. Norton, L. A. Suh, R. G. Carter, A. R. Weibman, K. E. Hulse, W. Stevens, et al. 2018. Short-chain fatty acids induce tissue plasminogen 48activator in airway epithelial cells via GPR41&43. Clinical and Experimental Allergy 48 (5):544–54. doi: 10.1111/cea.13119.
   PubMed Web of Science ®Google Scholar
• Inoue, D., I. Kimura, M. Wakabayashi, H. Tsumoto, K. Ozawa, T. Hara, Y. Takei, A. Hirasawa, Y. Ishihama, G. Tsujimoto, et al. 2012. Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation. FEBS Letters 586 (10):1547–54. doi: 10.1016/j.febslet.2012.04.021.
   PubMed Web of Science ®Google Scholar
• Jalanka, J., G. Major, K. Murray, G. Singh, A. Nowak, C. Kurtz, I. Silos-Santiago, J. M. Johnston, W. M. de Vos, and R. Spiller. 2019. The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls. International Journal of Molecular Sciences 20 (2):433. doi: 10.3390/ijms20020433.
   PubMed Web of Science ®Google Scholar
• Jaworska, K., M. Konop, K. Bielinska, T. Hutsch, M. Dziekiewicz, A. Banaszkiewicz, and M. Ufnal. 2019. Inflammatory bowel disease is associated with increased gut-to-blood penetration of short-chain fatty acids: A new, non-invasive marker of a functional intestinal lesion. Experimental Physiology 104 (8):1226–36. doi: 10.1113/EP087773.
   PubMed Web of Science ®Google Scholar
• Jiang, X. W., Y. T. Li, J. Z. Ye, L. X. Lv, L. Y. Yang, X. Y. Bian, W. R. Wu, J. J. Wu, D. Shi, Q. Wang, et al. 2020. New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism. World Journal of Gastroenterology 26 (40):6224–40. doi: 10.3748/wjg.v26.i40.6224.
   PubMed Web of Science ®Google Scholar
• Jiang, Y., K. Li, X. Li, L. Xu, and Z. Yang. 2021. Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice. Chemico-Biological Interactions 341:109452. doi: 10.1016/j.cbi.2021.109452.
   PubMed Web of Science ®Google Scholar
• Kaji, I., T. Iwanaga, M. Watanabe, P. H. Guth, E. Engel, J. D. Kaunitz, and Y. Akiba. 2015. SCFA transport in rat duodenum. American Journal of Physiology. Gastrointestinal and Liver Physiology 308 (3):G188–97. doi: 10.1152/ajpgi.00298.2014.
   PubMed Web of Science ®Google Scholar
• Khan, S, and G. B. Jena. 2014. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: Study in juvenile diabetic rat. Chemico-Biological Interactions 213:1–12. doi: 10.1016/j.cbi.2014.02.001.
   PubMed Web of Science ®Google Scholar
• Kibbie, J. J., S. M. Dillon, T. A. Thompson, C. M. Purba, M. D. McCarter, and C. C. Wilson. 2021. Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signalling. Immunobiology 226 (5):152126. doi: 10.1016/j.imbio.2021.152126.
   PubMed Web of Science ®Google Scholar
• Kihara, A. 2012. Very long-chain fatty acids: Elongation, physiology and related disorders. Journal of Biochemistry 152 (5):387–95. doi: 10.1093/jb/mvs105.
   PubMed Web of Science ®Google Scholar
• Kim, K., O. Kwon, T. Y. Ryu, C. R. Jung, J. Kim, J. K. Min, D. S. Kim, M. Y. Son, and H. S. Cho. 2019. Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer. Molecular Medicine Reports 20 (2):1569–74. doi: 10.3892/mmr.2019.10431.
   PubMed Web of Science ®Google Scholar
• Kim, M. H., S. G. Kang, J. H. Park, M. Yanagisawa, and C. H. Kim. 2013. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 145 (2):396–406.e10. doi: 10.1053/j.gastro.2013.04.056.
   PubMed Web of Science ®Google Scholar
• Kimura, I., A. Ichimura, R. Ohue-Kitano, and M. Igarashi. 2020. Free fatty acid receptors in health and disease. Physiological Reviews 100 (1):171–210. doi: 10.1152/physrev.00041.2018.
   PubMed Web of Science ®Google Scholar
• Kimura, I., D. Inoue, T. Maeda, T. Hara, A. Ichimura, S. Miyauchi, M. Kobayashi, A. Hirasawa, and G. Tsujimoto. 2011. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proceedings of the National Academy of Sciences of the United States of America 108108 (19):8030–5. doi: 10.1073/pnas.1016088108.
   PubMed Web of Science ®Google Scholar
• Kindt, A., G. Liebisch, T. Clavel, D. Haller, G. Hörmannsperger, H. Yoon, D. Kolmeder, A. Sigruener, S. Krautbauer, C. Seeliger, et al. 2018. The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nature Communications 9 (1):3760. doi: 10.1038/s41467-018-05767-4.
   PubMedGoogle Scholar
• Kobayashi, M., D. Mikami, H. Kimura, K. Kamiyama, Y. Morikawa, S. Yokoi, K. Kasuno, N. Takahashi, T. Taniguchi, M. Iwano, et al. 2017. Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signalling pathways in human renal cortical epithelial cells. Biochemical and Biophysical Research Communications 486 (2):499–505. doi: 10.1016/j.bbrc.2017.03.071.
   PubMed Web of Science ®Google Scholar
• Kobayashi, M., D. Mikami, J. Uwada, T. Yazawa, K. Kamiyama, H. Kimura, T. Taniguchi, and M. Iwano. 2018. A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signalling pathways in HepG2 cells. Oncotarget 9 9 (59):31342–54. doi: 10.18632/oncotarget.25809.
   PubMedGoogle Scholar
• Koh, A., F. De Vadder, P. Kovatcheva-Datchary, and F. Bäckhed. 2016. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell 165 (6):1332–45. doi: 10.1016/j.cell.2016.05.041.
   PubMed Web of Science ®Google Scholar
• Lagerström, M. C., and H. B. Schiöth. 2008. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nature Reviews. Drug Discovery 7 (4):339–57. doi: 10.1038/nrd2518.
   PubMed Web of Science ®Google Scholar
• Langhorst, J., A. K. Koch, P. Voiss, G. J. Dobos, and A. Rueffer. 2020. Distinct patterns of short-chain fatty acids during flare in patients with ulcerative colitis under treatment with mesalamine or a herbal combination of myrrh, chamomile flowers, and coffee charcoal: Secondary analysis of a randomized controlled trial. European Journal of Gastroenterology & Hepatology 32 (2):175–80. doi: 10.1097/MEG.0000000000001582.
   PubMed Web of Science ®Google Scholar
• Le, H. D., S. M. Loveday, H. Singh, and A. Sarkar. 2020. Gastrointestinal digestion of Pickering emulsions stabilised by hydrophobically modified cellulose nanocrystals: Release of short-chain fatty acids. Food Chemistry 320:126650. doi: 10.1016/j.foodchem.2020.126650.
   PubMed Web of Science ®Google Scholar
• Lee, J., J. d’Aigle, L. Atadja, V. Quaicoe, P. Honarpisheh, B. P. Ganesh, A. Hassan, J. Graf, J. Petrosino, N. Putluri, et al. 2020. Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice. Circulation Research 127 (4):453–65. doi: 10.1161/CIRCRESAHA.119.316448.
   PubMed Web of Science ®Google Scholar
• Lewandowski, E. D., R. K. Kudej, L. T. White, J. M. O’Donnell, and S. F. Vatner. 2002. Mitochondrial preference for short chain fatty acid oxidation during coronary artery constriction. Circulation 105 (3):367–72. doi: 10.1161/hc0302.102594.
   PubMed Web of Science ®Google Scholar
• Li, B., X. He, H.-Y. Jin, H.-Y. Wang, F.-C. Zhou, N.-Y. Zhang, D.-Y. Jie, L.-Z. Li, J. Su, X. Zheng, et al. 2021. Beneficial effects of Dendrobium officinale on metabolic hypertensive rats by triggering the enteric-origin SCFA-GPCR43/41 pathway. Food & Function 12 (12):5524–38. doi: 10.1039/d0fo02890h.
   PubMed Web of Science ®Google Scholar
• Li, C., Y. Cao, L. Zhang, J. Li, H. Wu, F. Ling, J. Zheng, J. Wang, B. Li, J. He, et al. 2020. LncRNA IGFBP4-1 promotes tumor development by activating Janus kinase-signal transducer and activator of transcription pathway in bladder urothelial carcinoma. International Journal of Biological Sciences 16 (13):2271–82. doi: 10.7150/ijbs.46986.
   PubMed Web of Science ®Google Scholar
• Li, J. M., R. Yu, L. P. Zhang, S. Y. Wen, S. J. Wang, X. Y. Zhang, Q. Xu, and L. D. Kong. 2019. Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: A benefit of short-chain fatty acids. Microbiome 7 (1):98. doi: 10.1186/s40168-019-0713-7.
   PubMed Web of Science ®Google Scholar
• Li, L., M. He, H. Xiao, X. Liu, K. Wang, and Y. Zhang. 2018a. Acetic acid influences BRL-3A cell lipid metabolism via the AMPK signalling pathway. Cellular Physiology and Biochemistry 45 (5):2021–30. doi: 10.1159/000487980.
   PubMedGoogle Scholar
• Li, L., M. Pan, S. Pan, W. Li, Y. Zhong, J. Hu, and S. Nie. 2020. Effects of insoluble and soluble fibers isolated from barley on blood glucose, serum lipids, liver function and caecal short-chain fatty acids in type 2 diabetic and normal rats. Food and Chemical Toxicology 135:110937. doi: 10.1016/j.fct.2019.110937.
   PubMed Web of Science ®Google Scholar
• Li, M., B. C. A. M. van Esch, P. A. J. Henricks, G. Folkerts, and J. Garssen. 2018b. The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor α-stimulated endothelial cells via activation of GPR41/43 and inhibition of HDACs. Frontiers in Pharmacology 9:533. doi: 10.3389/fphar.2018.00533.
   PubMed Web of Science ®Google Scholar
• Li, Q., H. Chen, M. Zhang, T. Wu, and R. Liu. 2019. Altered short-chain fatty acid profiles induced by dietary fiber intervention regulate AMPK levels and intestinal homeostasis. Food & Function 10 (11):7174–87. doi: 10.1039/c9fo01465a.
   PubMed Web of Science ®Google Scholar
• Li, Q., C. Ding, T. Meng, W. Lu, W. Liu, H. Hao, and L. Cao. 2017. Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signalling in histone deacetylase dependent manner. Journal of Pharmacological Sciences 135 (4):148–55. doi: 10.1016/j.jphs.2017.11.004.
   PubMed Web of Science ®Google Scholar
• Li, Y. J., X. Chen, T. K. Kwan, Y. W. Loh, J. Singer, Y. Liu, J. Ma, J. Tan, L. Macia, C. R. Mackay, et al. 2020. Dietary fiber protects against diabetic nephropathy through short-chain fatty acid-mediated activation of G protein-coupled receptors GPR43 and GPR109A. Journal of the American Society of Nephrology: JASN 31 (6):1267–81. doi: 10.1681/ASN.2019101029.
   PubMed Web of Science ®Google Scholar
• Liu, J., H. Li, T. Gong, W. Chen, S. Mao, Y. Kong, J. Yu, and J. Sun. 2020. Anti-neuroinflammatory effect of short-chain fatty acid acetate against Alzheimer’s disease via upregulating GPR41 and inhibiting ERK/JNK/NF-κB. Journal of Agricultural and Food Chemistry 68 (27):7152–61. doi: 10.1021/acs.jafc.0c02807.
   PubMed Web of Science ®Google Scholar
• Liu, L., C. Fu, and F. Li. 2019a. Acetate affects the process of lipid metabolism in rabbit liver, skeletal muscle and adipose tissue. Animals (Basel) 9 (10):799. doi: 10.3390/ani9100799.
   PubMedGoogle Scholar
• Liu, S., E. Li, Z. Sun, D. Fu, G. Duan, M. Jiang, Y. Yu, L. Mei, P. Yang, Y. Tang, et al. 2019. Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder. Scientific Reports 9 (1):287. doi: 10.1038/s41598-018-36430-z.
   PubMedGoogle Scholar
• Liu, X., C. Jiang, G. Liu, P. Wang, M. Shi, M. Yang, Z. Zhong, S. Ding, Y. Li, B. Liu, et al. 2020. Sodium butyrate protects against oxidative stress in human nucleus pulposus cells via elevating PPARγ-regulated Klotho expression. International Immunopharmacology 85:106657. doi: 10.1016/j.intimp.2020.106657.
   PubMed Web of Science ®Google Scholar
• Liu, Y., X. Jin, H. G. Hong, L. Xiang, Q. Jiang, Y. Ma, Z. Chen, L. Cheng, Z. Jian, Z. Wei, et al. 2020. The relationship between gut microbiota and short chain fatty acids in the renal calcium oxalate stones disease. FASEB Journal 34 (8):11200–14. doi: 10.1096/fj.202000786R.
   PubMed Web of Science ®Google Scholar
• Liu, Y., Y. J. Li, Y. W. Loh, J. Singer, W. Zhu, L. Macia, C. R. Mackay, W. Wang, S. J. Chadban, and H. Wu. 2021. Fiber derived microbial metabolites prevent acute kidney injury through G-protein coupled receptors and HDAC inhibition. Frontiers in Cell and Developmental Biology 9:648639. doi: 10.3389/fcell.2021.648639.
   PubMedGoogle Scholar
• Liu, Z., X. Dai, H. Zhang, R. Shi, Y. Hui, J. X. Zhang, W. Wang, L. Wang, Q. Wang, D. Wang, et al. 2020. X. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications 11 (1):855. doi: 10.1038/s41467-020-14676-4.
   PubMed Web of Science ®Google Scholar
• Louis, P., G. L. Hold, and H. J. Flint. 2014. The gut microbiota, bacterial metabolites and colorectal cancer. Nature Reviews. Microbiology 12 (10):661–72. doi: 10.1038/nrmicro3344.
   PubMed Web of Science ®Google Scholar
• Lu, S., S. Yin, C. Zhao, L. Fan, and H. Hu. 2020. Synergistic anti-colon cancer effect of glycyrol and butyrate is associated with the enhanced activation of caspase-3 and structural features of glycyrol. Food and Chemical Toxicology 136:110952. doi: 10.1016/j.fct.2019.110952.
   PubMed Web of Science ®Google Scholar
• Lu, Y., C. Fan, P. Li, Y. Lu, X. Chang, and K. Qi. 2016. Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G Protein-coupled receptors and gut microbiota. Scientific Reports 6:37589. doi: 10.1038/srep37589.
   PubMed Web of Science ®Google Scholar
• Luu, M., S. Pautz, V. Kohl, R. Singh, R. Romero, S. Lucas, J. Hofmann, H. Raifer, N. Vachharajani, L. C. Carrascosa, et al. 2019. The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes. Nature Communications 10 (1):760. doi: 10.1038/s41467-019-08711-2.
   PubMedGoogle Scholar
• Lymperopoulos, A., M. S. Suster, and J. I. Borges. 2022. Short-chain fatty acid receptors and cardiovascular function. International Journal of Molecular Sciences 23 (6):3303. doi: 10.3390/ijms23063303.
   PubMed Web of Science ®Google Scholar
• Machado, A. M., N. B. M. da Silva, R. M. P. de Freitas, M. B. D. de Freitas, J. B. P. Chaves, L. L. Oliveira, H. S. D. Martino, and R. de Cássia Gonçalves Alfenas. 2021. Effects of yacon flour associated with an energy restricted diet on intestinal permeability, fecal short chain fatty acids, oxidative stress and inflammation markers levels in adults with obesity or overweight: A randomized, double blind, placebo controlled clinical trial. Archives of Endocrinology and Metabolism 64 (5):597–607. doi: 10.20945/2359-3997000000225.
   PubMed Web of Science ®Google Scholar
• Machiels, K., M. Joossens, J. Sabino, V. De Preter, I. Arijs, V. Eeckhaut, V. Ballet, K. Claes, F. Van Immerseel, K. Verbeke, et al. 2014. S. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut 63 (8):1275–83. doi: 10.1136/gutjnl-2013-304833.
   PubMed Web of Science ®Google Scholar
• Macia, L., J. Tan, A. T. Vieira, K. Leach, D. Stanley, S. Luong, M. Maruya, C. Ian McKenzie, A. Hijikata, C. Wong, et al. 2015. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications 6:6734. doi: 10.1038/ncomms7734.
   PubMed Web of Science ®Google Scholar
• Mandaliya, D. K., and S. Seshadri. 2019. Short chain fatty acids, pancreatic dysfunction and type 2 diabetes. Pancreatology 19 (2):280–4. doi: 10.1016/j.pan.2019.01.021.
   PubMed Web of Science ®Google Scholar
• Mangian, H. F., and K. A. Tappenden. 2009. Butyrate increases GLUT2 mRNA abundance by initiating transcription in Caco2-BBe cells. Journal of Parenteral and Enteral Nutrition 33 (6):607–17. doi: 10.1177/0148607109336599.
   PubMed Web of Science ®Google Scholar
• Mariamenatu, A. H, and E. M. Abdu. 2021. Overconsumption of omega-6 polyunsaturated fatty acids (PUFAs) versus deficiency of omega-3 PUFAs in modern-day diets: The disturbing factor for their “balanced antagonistic metabolic functions” in the human body. Journal of Lipids 2021:8848161. doi: 10.1155/2021/8848161.
   PubMed Web of Science ®Google Scholar
• Maslowski, K. M., A. T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H. C. Schilter, M. S. Rolph, F. Mackay, D. Artis, et al. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461 (7268):1282–6. doi: 10.1038/nature08530.
   PubMed Web of Science ®Google Scholar
• Matheus, V. A., L. Monteiro, R. B. Oliveira, D. A. Maschio, and C. B. Collares-Buzato. 2017. Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice. Experimental Biology and Medicine (Maywood, N.J.) 242 (12):1214–26. doi: 10.1177/1535370217708188.
   PubMed Web of Science ®Google Scholar
• Michael, O. S., C. L. Dibia, O. A. Soetan, O. A. Adeyanju, A. L. Oyewole, O. O. Badmus, C. O. Adetunji, and A. O. Soladoye. 2020. Sodium acetate prevents nicotine-induced cardiorenal dysmetabolism through uric acid/creatine kinase-dependent pathway. Life Sciences 257:118127. doi: 10.1016/j.lfs.2020.118127.
   PubMed Web of Science ®Google Scholar
• Michels, N., T. Van de Wiele, and S. De Henauw. 2017. Chronic psychosocial stress and gut health in children: Associations with calprotectin and fecal short-chain fatty acids. Psychosomatic Medicine 79 (8):927–35. doi: 10.1097/PSY.0000000000000413.
   PubMed Web of Science ®Google Scholar
• Mikami, D., M. Kobayashi, J. Uwada, T. Yazawa, K. Kamiyama, K. Nishimori, Y. Nishikawa, S. Nishikawa, S. Yokoi, H. Kimura, et al. 2020a. Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1865 (6):158666. doi: 10.1016/j.bbalip.2020.158666.
   PubMed Web of Science ®Google Scholar
• Mikami, D., M. Kobayashi, J. Uwada, T. Yazawa, K. Kamiyama, K. Nishimori, Y. Nishikawa, S. Nishikawa, S. Yokoi, T. Taniguchi, et al. 2020b. AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition. Therapeutic Advances in Medical Oncology 12:1758835920913432. doi: 10.1177/1758835920913432.
   Web of Science ®Google Scholar
• Miletta, M. C., V. Petkovic, A. Eblé, R. A. Ammann, C. E. Flück, and P. E. Mullis. 2014. Butyrate increases intracellular calcium levels and enhances growth hormone release from rat anterior pituitary cells via the G-protein-coupled receptors GPR41 and 43. PLoS One 9 (10):e107388. doi: 10.1371/journal.pone.0107388.
   PubMed Web of Science ®Google Scholar
• Miyamoto, J., R. Ohue-Kitano, H. Mukouyama, A. Nishida, K. Watanabe, M. Igarashi, J. Irie, G. Tsujimoto, N. Satoh-Asahara, H. Itoh, et al. 2019. Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions. Proceedings of the National Academy of Sciences of the United States of America 116 (47):23813–21. doi: 10.1073/pnas.1912573116.
   PubMed Web of Science ®Google Scholar
• Mizuta, K., H. Sasaki, Y. Zhang, A. Matoba, and C. W. Emala. Sr, 2020. The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology 318 (6):L1248–L1260. doi: 10.1152/ajplung.00357.2019.
   PubMed Web of Science ®Google Scholar
• Nakkarach, A., H. L. Foo, A. A.-L. Song, N. E. A. Mutalib, S. Nitisinprasert, and U. Withayagiat. 2021. Anti-cancer and anti-inflammatory effects elicited by short chain fatty acids produced by Escherichia coli isolated from healthy human gut microbiota. Microbial Cell Factories 20 (1):36. doi: 10.1186/s12934-020-01477-z.
   PubMed Web of Science ®Google Scholar
• Natarajan, N., D. Hori, S. Flavahan, J. Steppan, N. A. Flavahan, D. E. Berkowitz, and J. L. Pluznick. 2016. Microbial short-chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41. Physiological Genomics 48 (11):826–34. doi: 10.1152/physiolgenomics.00089.2016.
   PubMed Web of Science ®Google Scholar
• Nooromid, M., E. B. Chen, L. Xiong, K. Shapiro, Q. Jiang, F. Demsas, M. Eskandari, M. Priyadarshini, E. B. Chang, B. T. Layden, et al. 2020. Microbe-derived butyrate and its receptor, free fatty acid receptor 3, but not free fatty acid receptor 2, mitigate neointimal hyperplasia susceptibility after arterial injury. Journal of the American Heart Association 9 (13):e016235. doi: 10.1161/JAHA.120.016235.
   PubMed Web of Science ®Google Scholar
• Ohara, T, and T. Mori. 2019. Antiproliferative effects of short-chain fatty acids on human colorectal cancer cells via gene expression inhibition. Anticancer Research 39 (9):4659–66. doi: 10.21873/anticanres.13647.
   PubMed Web of Science ®Google Scholar
• Okabe, S., T. Okamoto, C. M. Zhao, D. Chen, and H. Matsui. 2014. Acetic acid induces cell death: An in vitro study using normal rat gastric mucosal cell line and rat and human gastric cancer and mesothelioma cell lines. Journal of Gastroenterology and Hepatology 29:65–9. doi: 10.1111/jgh.12775.
   PubMed Web of Science ®Google Scholar
• Olaniyi, K. S., O. A. Amusa, E. D. Areola, and L. A. Olatunji. 2020. Suppression of HDAC by sodium acetate rectifies cardiac metabolic disturbance in streptozotocin-nicotinamide-induced diabetic rats. Experimental Biology and Medicine (Maywood, N.J.) 245 (7):667–76. doi: 10.1177/1535370220913847.
   PubMed Web of Science ®Google Scholar
• Onyszkiewicz, M., M. Gawrys-Kopczynska, P. Konopelski, M. Aleksandrowicz, A. Sawicka, E. Koźniewska, E. Samborowska, and M. Ufnal. 2019. Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signalling and GPR41/43 receptors. Pflugers Archiv: European Journal of Physiology 471 (11–12):1441–53. doi: 10.1007/s00424-019-02322-y.
   PubMed Web of Science ®Google Scholar
• Onyszkiewicz, M., M. Gawrys-Kopczynska, M. Sałagaj, M. Aleksandrowicz, A. Sawicka, E. Koźniewska, E. Samborowska, and M. Ufnal. 2020. Valeric acid lowers arterial blood pressure in rats. European Journal of Pharmacology 875:173086. doi: 10.1016/j.ejphar.2020.173086.
   Google Scholar
• Ooyama, K., K. Kojima, T. Aoyama, and H. Takeuchi. 2009. Decrease of food intake in rats after ingestion of medium-chain triacylglycerol. Journal of Nutritional Science and Vitaminology 55 (5):423–7. doi: 10.3177/jnsv.55.423.
   PubMed Web of Science ®Google Scholar
• Parada Venegas, D., M. K. De la Fuente, G. Landskron, M. J. González, R. Quera, G. Dijkstra, H. J. M. Harmsen, K. N. Faber, and M. A. Hermoso. 2019. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology 10:1486. doi: 10.3389/fimmu.2019.01486.
   PubMed Web of Science ®Google Scholar
• Park, C., N. Meghani, H. Amin, P. H. Tran, T. T. Tran, V. H. Nguyen, and B. J. Lee. 2019. The roles of short and long chain fatty acids on physicochemical properties and improved cancer targeting of albumin-based fattigation-platform nanoparticles containing doxorubicin. International Journal of Pharmaceutics 564:124–35. doi: 10.1016/j.ijpharm.2019.04.038.
   PubMed Web of Science ®Google Scholar
• Park, J., M. Kim, S. G. Kang, A. H. Jannasch, B. Cooper, J. Patterson, and C. H. Kim. 2015. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunology 8 (1):80–93. doi: 10.1038/mi.2014.44.
   PubMed Web of Science ®Google Scholar
• Patnala, R., T. V. Arumugam, N. Gupta, and S. T. Dheen. 2017. HDAC Inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke. Molecular Neurobiology 54 (8):6391–411. doi: 10.1007/s12035-016-0149-z.
   PubMed Web of Science ®Google Scholar
• Pattayil, L., and H. T. Balakrishnan-Saraswathi. 2019. In vitro evaluation of apoptotic induction of butyric acid derivatives in colorectal carcinoma cells. Anticancer Research 39 (7):3795–801. doi: 10.21873/anticanres.
   PubMed Web of Science ®Google Scholar
• Pham, C. H., J. E. Lee, J. Yu, S. H. Lee, K. R. Yu, J. Hong, N. Cho, S. Kim, D. Kang, S. Lee, et al. 2021. Anticancer effects of propionic acid inducing cell death in cervical cancer cells. Molecules 26 (16):4951. doi: 10.3390/molecules26164951.
   PubMed Web of Science ®Google Scholar
• Pingitore, A., E. S. Chambers, T. Hill, I. R. Maldonado, B. Liu, G. Bewick, D. J. Morrison, T. Preston, G. A. Wallis, C. Tedford, et al. 2017. The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes, Obesity & Metabolism 19 (2):257–65. doi: 10.1111/dom.12811.
   PubMed Web of Science ®Google Scholar
• Pirozzi, C., A. Lama, C. Annunziata, G. Cavaliere, C. De Caro, R. Citraro, E. Russo, M. Tallarico, M. Iannone, M. C. Ferrante, et al. 2020. Butyrate prevents valproate-induced liver injury: In vitro and in vivo evidence. FASEB Journal 34 (1):676–90. doi: 10.1096/fj.201900927RR.
   PubMed Web of Science ®Google Scholar
• Pluznick, J. 2014. A novel SCFA receptor, the microbiota, and blood pressure regulation. Gut Microbes 5 (2):202–7. doi: 10.4161/gmic.27492.
   PubMed Web of Science ®Google Scholar
• Poll, B. G., J. Xu, S. Jun, J. Sanchez, N. A. Zaidman, X. He, L. Lester, D. E. Berkowitz, N. Paolocci, W. D. Gao, et al. 2021. Acetate, a short-chain fatty acid, acutely lowers heart rate and cardiac contractility along with blood pressure. The Journal of Pharmacology and Experimental Therapeutics 377 (1):39–50. doi: 10.1124/jpet.120.000187.
   PubMed Web of Science ®Google Scholar
• Prinz, M., S. Jung, and J. Priller. 2019. Microglia biology: One century of evolving concepts. Cell 179 (2):292–311. doi: 10.1016/j.cell.2019.08.053.
   PubMed Web of Science ®Google Scholar
• Priyadarshini, M., K. U. Kotlo, P. K. Dudeja, and B. T. Layden. 2018. Role of short chain fatty acid receptors in intestinal physiology and pathophysiology. Comprehensive Physiology 8 (3):1091–115. doi: 10.1002/cphy.c170050.
   PubMed Web of Science ®Google Scholar
• Psichas, A., M. L. Sleeth, K. G. Murphy, L. Brooks, G. A. Bewick, A. C. Hanyaloglu, M. A. Ghatei, S. R. Bloom, and G. Frost. 2015. The short-chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. International Journal of Obesity (2005) 39 (3):424–9. doi: 10.1038/ijo.2014.153.
   PubMed Web of Science ®Google Scholar
• Quagliariello, V., M. Masarone, E. Armenia, A. Giudice, M. Barbarisi, M. Caraglia, A. Barbarisi, and M. Persico. 2019. Chitosan-coated liposomes loaded with butyric acid demonstrate anticancer and anti-inflammatory activity in human hepatoma HepG2 cells. Oncology Reports 41 (3):1476–86. doi: 10.3892/or.2018.6932.
   PubMed Web of Science ®Google Scholar
• Ratnayake, W. M, and C. Galli. 2009. Fat and fatty acid terminology, methods of analysis and fat digestion and metabolism: A background review paper. Annals of Nutrition & Metabolism 55 (1-3):8–43. doi: 10.1159/000228994.
   PubMed Web of Science ®Google Scholar
• Reichardt, N., S. H. Duncan, P. Young, A. Belenguer, C. McWilliam Leitch, K. P. Scott, H. J. Flint, and P. Louis. 2014. Phylogenetic distribution of three pathways for propionate production within the human gut microbiota [published correction appears in ISME J. 2014 Jun;8(6):1352]. The ISME Journal 8 (6):1323–35. doi: 10.1038/ismej.2014.14.
   PubMed Web of Science ®Google Scholar
• Rephaeli, A., S. Waks-Yona, A. Nudelman, I. Tarasenko, N. Tarasenko, D. R. Phillips, S. M. Cutts, and G. Kessler-Icekson. 2007. Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity. British Journal of Cancer 96 (11):1667–74. doi: 10.1038/sj.bjc.6603781.
   PubMed Web of Science ®Google Scholar
• Robles-Vera, I., M. Toral, N. de la Visitación, M. Sánchez, M. Gómez-Guzmán, M. Romero, T. Yang, J. L. Izquierdo-Garcia, R. Jiménez, J. Ruiz-Cabello, et al. 2020. Probiotics prevent dysbiosis and the rise in blood pressure in genetic hypertension: Role of short-chain fatty acids. Molecular Nutrition & Food Research 64 (6):e1900616. doi: 10.1002/mnfr.201900616.
   PubMed Web of Science ®Google Scholar
• Rosser, E. C., C. J. M. Piper, D. E. Matei, P. A. Blair, A. F. Rendeiro, M. Orford, D. G. Alber, T. Krausgruber, D. Catalan, N. Klein, et al. 2020. Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells. Cell Metabolism 31 (4):837–51.e10. doi: 10.1016/j.cmet.2020.03.003.
   PubMed Web of Science ®Google Scholar
• Roy, R., C. Nguyen-Ngo, and M. Lappas. 2020. Short-chain fatty acids as novel therapeutics for gestational diabetes. Journal of Molecular Endocrinology 65 (2):21–34. doi: 10.1530/JME-20-0094.
   PubMed Web of Science ®Google Scholar
• Rumberger, J. M., J. R. Arch, and A. Green. 2014. Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes. Peer J 2 2:e611. doi: 10.7717/peerj.611.
   PubMed Web of Science ®Google Scholar
• Ryu, T. Y., K. Kim, M. Y. Son, J. K. Min, J. Kim, T. S. Han, D. S. Kim, and H. S. Cho. 2019. Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer. Oncology Reports 41 (3):1691–9. doi: 10.3892/or.2018.6938.
   PubMed Web of Science ®Google Scholar
• Sacco, P., E. Decleva, F. Tentor, R. Menegazzi, M. Borgogna, S. Paoletti, K. A. Kristiansen, K. M. Vårum, and E. Marsich. 2017. Butyrate-loaded chitosan/hyaluronan nanoparticles: A suitable tool for sustained inhibition of ROS release by activated neutrophils. Macromolecular Bioscience 17 (11):1700214. doi: 10.1002/mabi.201700214.
   Web of Science ®Google Scholar
• Sadler, R., J. V. Cramer, S. Heindl, S. Kostidis, D. Betz, K. R. Zuurbier, B. H. Northoff, M. Heijink, M. P. Goldberg, E. J. Plautz, et al. 2020. Short-chain fatty acids improve poststroke recovery via immunological mechanisms. The Journal of Neuroscience 40 (5):1162–73. doi: 10.1523/JNEUROSCI.1359-19.2019.
   PubMed Web of Science ®Google Scholar
• Sahuri-Arisoylu, M., L. P. Brody, J. R. Parkinson, H. Parkes, N. Navaratnam, A. D. Miller, E. L. Thomas, G. Frost, and J. D. Bell. 2016. Reprogramming of hepatic fat accumulation and ‘browning’ of adipose tissue by the short-chain fatty acid acetate. International Journal of Obesity (2005) 40 (6):955–63. doi: 10.1038/ijo.2016.23.
   PubMed Web of Science ®Google Scholar
• Sanford, J. A., L. J. Zhang, M. R. Williams, J. A. Gangoiti, C. M. Huang, and R. L. Gallo. 2016. Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands. Science Immunology 1:eaah4609. doi: 10.1126/sciimmunol.aah4609.
   PubMed Web of Science ®Google Scholar
• Sawin, E. A., T. J. De Wolfe, B. Aktas, B. M. Stroup, S. G. Murali, J. L. Steele, and D. M. Ney. 2015. Glycomacropeptide is a prebiotic that reduces Desulfovibrio bacteria, increases cecal short-chain fatty acids, and is anti-inflammatory in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology 309 (7):G590–G601. doi: 10.1152/ajpgi.00211.2015.
   PubMed Web of Science ®Google Scholar
• Schilderink, R., C. Verseijden, J. Seppen, V. Muncan, G. R. van den Brink, T. T. Lambers, E. A. van Tol, and W. J. de Jonge. 2016. The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC. American Journal of Physiology. Gastrointestinal and Liver Physiology 310 (11):G1138–G1146. doi: 10.1152/ajpgi.00411.2015.
   PubMed Web of Science ®Google Scholar
• Schönfeld, P., and L. Wojtczak. 2016. Short- and medium-chain fatty acids in energy metabolism: The cellular perspective. Journal of Lipid Research 57 (6):943–54. doi: 10.1194/jlr.R067629.
   PubMed Web of Science ®Google Scholar
• Sette, S., C. Le Donne, R. Piccinelli, D. Arcella, A. Turrini, and C. Leclercq. 2011. The third Italian National Food Consumption Survey, INRAN-SCAI 2005-06—Part 1: Nutrient intakes in Italy. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD 21 (12):922–32. doi: 10.1016/j.numecd.2010.03.001.
   PubMed Web of Science ®Google Scholar
• Shah, S., T. Fillier, T. H. Pham, R. Thomas, and S. K. Cheema. 2021. Intraperitoneal administration of short-chain fatty acids improves lipid metabolism of long-evans rats in a sex-specific manner. Nutrients 13 (3):892. doi: 10.3390/nu13030892.
   PubMed Web of Science ®Google Scholar
• Shimizu, H., Y. Masujima, C. Ushiroda, R. Mizushima, S. Taira, R. Ohue-Kitano, and I. Kimura. 2019. Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3. Scientific Reports 9 (1):16574. doi: 10.1038/s41598-019-53242-x.
   PubMedGoogle Scholar
• Shimizu, H., Y. Masujima, C. Ushiroda, R. Mizushima, S. Taira, R. Ohue-Kitano, and I. Kimura. 2013. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339:211–4. doi: 10.1126/science.1227166.
   PubMed Web of Science ®Google Scholar
• Shin, C., Y. Lim, H. Lim, and T. B. Ahn. 2020. Plasma short-chain fatty acids in patients with Parkinson’s Disease. Movement Disorders 35 (6):1021–7. doi: 10.1002/mds.28016.
   PubMed Web of Science ®Google Scholar
• Si, X., W. Shang, Z. Zhou, G. Shui, S. M. Lam, C. Blanchard, and P. Strappe. 2018. Gamma-aminobutyric acid enriched rice bran diet attenuates insulin resistance and balances energy expenditure via modification of gut microbiota and short-chain fatty acids. Journal of Agricultural and Food Chemistry 66 (4):881–90. doi: 10.1021/acs.jafc.7b04994.
   PubMed Web of Science ®Google Scholar
• Sifat, A. E., B. Vaidya, and T. J. Abbruscato. 2017. Blood-brain barrier protection as a therapeutic strategy for acute ischemic stroke. The AAPS Journal 19 (4):957–72. doi: 10.1208/s12248-017-0091-7.
   PubMed Web of Science ®Google Scholar
• Singh, N. P, and H. C. Lai. 2005. Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells. Anticancer Res. 25:4325–31.
   PubMed Web of Science ®Google Scholar
• Sivaprakasam, S., Y. D. Bhutia, S. Yang, and V. Ganapathy. 2017. Short-chain fatty acid transporters: Role in colonic homeostasis. Comprehensive Physiology 8 (1):299–314. doi: 10.1002/cphy.c170014.
   PubMed Web of Science ®Google Scholar
• Smith, S. A., S. A. Ogawa, L. Chau, K. A. Whelan, K. E. Hamilton, J. Chen, L. Tan, E. Z. Chen, S. Keilbaugh, F. Fogt, et al. 2021. Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines. J Clin Invest 131:e133371. doi: 10.1172/JCI133371.
   PubMed Web of Science ®Google Scholar
• Song, R., J. Yao, Q. Shi, and R. Wei. 2018. Nanocomposite of half-fin anchovy hydrolysates/zinc oxide nanoparticles exhibits actual non-toxicity and regulates intestinal microbiota, short-chain fatty acids production and oxidative status in mice. Mar Drugs. 16 (1):23. doi: 10.3390/md16010023.
   PubMed Web of Science ®Google Scholar
• Su, Y., H. K. Wang, X. P. Gan, L. Chen, Y. N. Cao, D. C. Cheng, D. Y. Zhang, W. Y. Liu, F. F. Li, and X. M. Xu. 2021. Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population. Journal of Translational Medicine 19 (1):366. doi: 10.1186/s12967-021-03040-9.
   PubMed Web of Science ®Google Scholar
• Sun, M., W. Wu, L. Chen, W. Yang, X. Huang, M. C. Chen, F. Xiao, Y. Zhao, Y. M. C. Yao, S. Carpio, et al. 2018. Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Nature Communications 9 (1):3555. doi: 10.1038/s41467-018-05901-2.
   PubMedGoogle Scholar
• Sun, M., W. Wu, Z. Liu, and Y. Cong. 2017. Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. Journal of Gastroenterology 52 (1):1–8. doi: 10.1007/s00535-016-1242-9.
   PubMed Web of Science ®Google Scholar
• Sun, Y., T. Yan, G. Gong, Y. Li, J. Zhang, B. Wu, K. Bi, and Y. Jia. 2020. Antidepressant-like effects of Schisandrin on lipopolysaccharide-induced mice: Gut microbiota, short-chain fatty acid and TLR4/NF-κB signalling pathway. International Immunopharmacology 89 (Pt A):107029, 10–1016/j. intimp.2020.107029. doi: 10.1016/j.intimp.2020.107029.
   Google Scholar
• Szentirmai, É., N. S. Millican, A. R. Massie, and L. Kapás. 2019. Butyrate, a metabolite of intestinal bacteria, enhances sleep. Scientific Reports 9 (1):7035. doi: 10.1038/s41598-019-43502-1.
   PubMedGoogle Scholar
• Tan, C., Q. Wu, H. Wang, X. Gao, R. Xu, Z. Cui, J. Zhu, X. Zeng, H. Zhou, Y. He, et al. 2021. Dysbiosis of gut microbiota and short-chain fatty acids in acute ischemic stroke and the subsequent risk for poor functional outcomes. JPEN. Journal of Parenteral and Enteral Nutrition 45 (3):518–29. doi: 10.1002/jpen.1861.
   PubMed Web of Science ®Google Scholar
• Tang, R, and L. Li. 2021. Modulation of short-chain fatty acids as potential therapy method for type 2 diabetes mellitus. Canadian Journal of Infectious Diseases and Medical Microbiology. 2021:1–13. doi: 10.1155/2021/6632266.
   Web of Science ®Google Scholar
• Tang, Y., Y. Chen, H. Jiang, and D. Nie. 2011. The role of short-chain fatty acids in orchestrating two types of programmed cell death in colon cancer. Autophagy 7 (2):235–7. doi: 10.4161/auto.7.2.14277.
   PubMed Web of Science ®Google Scholar
• Tayyeb, J. Z., H. E. Popeijus, R. P. Mensink, M. C. J. M. Konings, K. H. R. Mulders, and J. Plat. 2019. The effects of short-chain fatty acids on the transcription and secretion of apolipoprotein A-I in human hepatocytes in vitro. Journal of Cellular Biochemistry 120 (10):17219–27. doi: 10.1002/jcb.28982.
   PubMed Web of Science ®Google Scholar
• Thandapilly, S. J., S. P. Ndou, Y. Wang, C. M. Nyachoti, and N. P. Ames. 2018. Barley β-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals. Food & Function 9 (6):3092–6. doi: 10.1039/C8FO00157J.
   PubMed Web of Science ®Google Scholar
• Tolhurst, G., H. Heffron, Y. S. Lam, H. E. Parker, A. M. Habib, E. Diakogiannaki, J. Cameron, J. Grosse, F. Reimann, and F. M. Gribble. 2012. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61 (2):364–71. doi: 10.2337/db11-1019.
   PubMed Web of Science ®Google Scholar
• Usman, T. O., E. D. Areola, O. O. Badmus, I. Kim, and L. A. Olatunji. 2018. Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: Roles of adenosine deaminase and xanthine oxidase activities. The Journal of Nutritional Biochemistry 62:65–75. doi: 10.1016/j.jnutbio.2018.08.018.
   PubMed Web of Science ®Google Scholar
• Valcheva, R., P. Koleva, I. Martínez, J. Walter, M. G. Gänzle, and L. A. Dieleman. 2019. Inulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels. Gut Microbes 10 (3):334–57. doi: 10.1080/19490976.2018.1526583.
   PubMed Web of Science ®Google Scholar
• van der Beek, C. M., E. E. Canfora, A. M. Kip, S. H. M. Gorissen, S. W. M. Olde Damink, H. M. van Eijk, J. J. Holst, E. E. Blaak, C. H. C. Dejong, and K. Lenaerts. 2018. The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men. Metabolism 87:25–35. doi: 10.1016/j.metabol.2018.06.009.
   PubMed Web of Science ®Google Scholar
• Verhaar, B. J. H., D. Collard, A. Prodan, J. H. M. Levels, A. H. Zwinderman, F. Bäckhed, L. Vogt, M. J. L. Peters, M. Muller, M. Nieuwdorp, et al. 2020. Associations between gut microbiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: The HELIUS study. European Heart Journal 41 (44):4259–67. doi: 10.1093/eurheartj/ehaa704.
   PubMed Web of Science ®Google Scholar
• Vital, M., A. C. Howe, and J. M. Tiedje. 2014. Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data. mBio 5 (2):e00889-14. doi: 10.1128/mBio.00889-14.
   PubMed Web of Science ®Google Scholar
• Wang, G., Q. Si, S. Yang, T. Jiao, H. Zhu, P. Tian, L. Wang, X. Li, L. Gong, J. Zhao, et al. 2020. Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners. Food & Function 11 (7):5898–914. doi: 10.1039/c9fo02761k.
   PubMed Web of Science ®Google Scholar
• Wang, J., M. Cui, F. Sun, K. Zhou, B. Fan, J. H. Qiu, and F. Q. Chen. 2020. HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice. International Journal of Molecular Medicine 45 (4):1150–62. doi: 10.3892/ijmm.2020.4489.
   PubMed Web of Science ®Google Scholar
• Wang, S., D. Lv, S. Jiang, J. Jiang, M. Liang, F. Hou, and Y. Chen. 2019. Quantitative reduction in short-chain fatty acids, especially butyrate, contributes to the progression of chronic kidney disease. Clinical Science 133 (17):1857–70. doi: 10.1042/CS20190171.
   PubMed Web of Science ®Google Scholar
• Wang, Z., X. Zhang, L. Zhu, X. Yang, F. He, T. Wang, T. Bao, H. Lu, H. Wang, and S. Yang. 2020. Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice. International Immunopharmacology 78:106062. doi: 10.1016/j.intimp.2019.106062.
   PubMed Web of Science ®Google Scholar
• Weber, G. J., J. Foster, S. B. Pushpakumar, and U. Sen. 2018. Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation. Pharmacological Research 134:157–65. doi: 10.1016/j.phrs.2018.06.012.
   PubMed Web of Science ®Google Scholar
• Weinberg, Z. Y, and M. A. Puthenveedu. 2019. Regulation of G protein-coupled receptor signalling by plasma membrane organization and endocytosis. Traffic (Copenhagen, Denmark) 20 (2):121–9. doi: 10.1111/tra.12628.
   PubMed Web of Science ®Google Scholar
• Wenzel, T. J., E. J. Gates, A. L. Ranger, and A. Klegeris. 2020. Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells. Molecular and Cellular Neurosciences 105:103493. doi: 10.1016/j.mcn.2020.103493.
   PubMed Web of Science ®Google Scholar
• Wu, H., E. Esteve, V. Tremaroli, M. T. Khan, R. Caesar, L. Mannerås-Holm, M. Ståhlman, L. M. Olsson, M. Serino, M. Planas-Fèlix, et al. 2017. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine 23 (7):850–8. doi: 10.1038/nm.4345.
   PubMed Web of Science ®Google Scholar
• Wu, J., Z. Zhou, Y. Hu, and S. Dong. 2012. Butyrate-induced Gpr41 activation inhibits histone acetylation and cell growth. Journal of Genetics and Genomics = Yi Chuan Xue Bao 39 (8):375–84. doi: 10.1016/j.jgg.2012.05.008.
   PubMed Web of Science ®Google Scholar
• Wu, M., T. Tian, Q. Mao, T. Zou, C.-J. Zhou, J. Xie, and J.-J. Chen. 2020. Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice. Translational Psychiatry 10 (1):350. doi: 10.1038/s41398-020-01038-3.
   PubMed Web of Science ®Google Scholar
• Xiao, S., Z. Zhang, M. Chen, J. Zou, S. Jiang, D. Qian, and J. Duan. 2019. Xie Xin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism. Journal of Ethnopharmacology 241:112032. doi: 10.1016/j.jep.2019.112032.
   PubMed Web of Science ®Google Scholar
• Xiu, W., Q. Chen, Z. Wang, J. Wang, and Z. Zhou. 2020. Microbiota-derived short chain fatty acid promotion of Amphiregulin expression by dendritic cells is regulated by GPR43 and Blimp-1. Biochemical and Biophysical Research Communications 533 (3):282–8. doi: 10.1016/j.bbrc.2020.09.027.
   PubMed Web of Science ®Google Scholar
• Yan, F., N. Li, J. Shi, H. Li, Y. Yue, W. Jiao, N. Wang, Y. Song, G. Huo, B. Li, et al. 2019. Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice. Food & Function 10 (9):5804–15. doi: 10.1039/c9fo01062a.
   PubMed Web of Science ®Google Scholar
• Yan, L., L. Wang, S. Gao, C. Liu, Z. Zhang, A. Ma, and L. Zheng. 2020. Celery cellulose hydrogel as carriers for controlled release of short-chain fatty acid by ultrasound. Food Chemistry 309:125717. doi: 10.1016/j.foodchem.2019.125717.
   PubMed Web of Science ®Google Scholar
• Yang, L. L., V. Millischer, S. Rodin, D. F. MacFabe, J. C. Villaescusa, and C. Lavebratt. 2020a. Enteric short-chain fatty acids promote proliferation of human neural progenitor cells. Journal of Neurochemistry 154 (6):635–46. doi: 10.1111/jnc.14928.
   PubMed Web of Science ®Google Scholar
• Yang, W., T. Yu, X. Huang, A. J. Bilotta, L. Xu, Y. Lu, J. Sun, F. Pan, J. Zhou, W. Zhang, et al. 2020b. Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity. Nature Communications 11 (1):4457. doi: 10.1038/s41467-020-18262-6.
   PubMed Web of Science ®Google Scholar
• Yoon, S., G. Kang, and G. H. Eom. 2019. HDAC inhibitors: Therapeutic potential in fibrosis-associated human diseases. International Journal of Molecular Sciences 20 (6):1329. doi: 10.3390/ijms20061329.
   PubMed Web of Science ®Google Scholar
• Yu, H., R. Li, H. Huang, R. Yao, and S. Shen. 2018. Short-chain fatty acids enhance the lipid accumulation of 3T3-L1 cells by modulating the expression of enzymes of fatty acid metabolism. Lipids 53 (1):77–84. doi: 10.1002/lipd.12005.
   PubMed Web of Science ®Google Scholar
• Yu, H., L. Qin, H. Hu, and Z. Wang. 2019. Alteration of the gut microbiota and its effect on AMPK/NADPH oxidase signalling pathway in 2K1C rats. BioMed Research International 2019:8250619. () doi: 10.1155/2019/8250619.
   PubMed Web of Science ®Google Scholar
• Yuan, T., L. Wang, J. Jin, L. Mi, J. Pang, Z. Liu, J. Gong, C. Sun, J. Li, W. Wei, et al. 2022. Role medium-chain fatty acids in the lipid metabolism of infants. Frontiers in Nutrition 9:1195. doi: 10.3389/fnut.2022.804880.
   Web of Science ®Google Scholar
• Zhang, J., H. Zhang, M. Liu, Y. Lan, H. Sun, K. Mai, and M. Wan. 2020. Short-chain fatty acids promote intracellular bactericidal ­activity in head kidney macrophages from turbot (Scophthalmus maximus L.) via hypoxia-inducible factor-1α. Frontiers in Immunology 11:615536–10. 3389/fimmu.2020.615536. doi: 10.3389/fimmu.2020.615536.
   PubMed Web of Science ®Google Scholar
• Zhang, L., Y. Wang, X. Xiayu, C. Shi, W. Chen, N. Song, X. Fu, R. Zhou, Y. F. Xu, L. Huang, et al. 2017. Altered gut microbiota in a mouse model of Alzheimer’s disease. Journal of Alzheimer’s Disease 60 (4):1241–57. - doi: 10.3233/JAD-170020.
   PubMed Web of Science ®Google Scholar
• Zhang, S., J. Bai, S. Ren, R. Wang, L. Zhang, and Y. Zuo. 2012. Sodium butyrate restores ASC expression and induces apoptosis in LS174T cells. International Journal of Molecular Medicine 30 (6):1431–7. doi: 10.3892/ijmm.2012.1156.
   PubMed Web of Science ®Google Scholar
• Zhao, L., H. Lou, Y. Peng, S. Chen, L. Fan, and X. Li. 2020. Elevated levels of circulating short-chain fatty acids and bile acids in type 2 diabetes are linked to gut barrier disruption and disordered gut microbiota. Diabetes Research and Clinical Practice 169:108418. doi: 10.1016/j.diabres.2020.108418.
   PubMed Web of Science ®Google Scholar
• Zhou, L., M. Zhang, Y. Wang, R. G. Dorfman, H. Liu, T. Yu, X. Chen, D. Tang, L. Xu, Y. Yin, et al. 2018. Faecali bacteriumprausnitzii produces butyrate to maintain th17/treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1. Inflammatory Bowel Diseases 24 (9):1926–40. doi: 10.1093/ibd/izy182.
   PubMed Web of Science ®Google Scholar
• Zhu, L., L. Z. Xu, S. Zhao, Z. F. Shen, H. Shen, and L. B. Zhan. 2020. Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis. Applied Microbiology and Biotechnology 104 (12):5449–60. doi: 10.1007/s00253-020-10527-w.
   PubMed Web of Science ®Google Scholar
• Zou, F., Y. Qiu, Y. Huang, H. Zou, X. Cheng, Q. Niu, A. Luo, and J. Sun. 2021. Effects of short-chain fatty acids in inhibiting HDAC and activating p38 MAPK are critical for promoting B10 cell generation and function. Cell Death & Disease 12 (6):582. doi: 10.1038/s41419-021-03880-9.
   PubMed Web of Science ®Google Scholar
• Zou, Y., S. Fineberg, A. Pearlman, R. D. Feinman, and E. J. Fine. 2020. The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer. PLoS One 15 (12):e0233662. doi: 10.1371/journal.pone.0233662.
   PubMed Web of Science ®Google Scholar