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Systematic Review

Benefits of probiotic use on COVID-19: A systematic review and meta-analysis

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References

  • Ader, F., M. Bouscambert-Duchamp, M. Hites, N. Peiffer-Smadja, J. Poissy, D. Belhadi, A. Diallo, M.-P. Lê, G. Peytavin, T. Staub, DisCoVeRy Study Group, et al. 2022. Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): A phase 3, randomised, controlled, open-label trial. The Lancet. Infectious Diseases 22 (2):209–21. doi: 10.1016/S1473-3099(21)00485-0.
  • Ahrén, I. L., M. Hillman, E. A. Nordström, N. Larsson, and T. M. Niskanen. 2021. Fewer community-acquired colds with daily consumption of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2. A randomized, placebo-controlled clinical trial. The Journal of Nutrition 151 (1):214–22. doi: 10.1093/jn/nxaa353.
  • Altadill, T., J. Espadaler-Mazo, and M. T. Liong. 2021. Effects of a Lactobacilli probiotic on reducing duration of urti and fever, and use of URTI-associated medicine: A re-analysis of a randomized, placebo-controlled study. Microorganisms 9 (3):528. doi: 10.3390/microorganisms9030528.
  • Balduzzi, S., G. Rücker, and G. Schwarzer. 2019. How to perform a meta-analysis with R: A practical tutorial. Evidence-Based Mental Health 22 (4):153–60. doi: 10.1136/ebmental-2019-300117.
  • Beigel, J. H., K. M. Tomashek, L. E. Dodd, A. K. Mehta, B. S. Zingman, A. C. Kalil, E. Hohmann, H. Y. Chu, A. Luetkemeyer, S. Kline, et al. 2020. Remdesivir for the treatment of Covid-19—Final report. New England Journal of Medicine 383 (19):1813–26. doi: 10.1056/NEJMoa2007764.
  • Bermudez-Brito, M., J. Plaza-Díaz, S. Muñoz-Quezada, C. Gómez-Llorente, and A. Gil. 2012. Probiotic mechanisms of action. Annals of Nutrition & Metabolism 61 (2):160–74. doi: 10.1159/000342079.
  • Bozkurt, H. S., and Ö. Bilen. 2021. Oral booster probiotic bifidobacteria in SARS-COV-2 patients. International Journal of Immunopathology and Pharmacology 35:20587384211059677. doi: 10.1177/20587384211059677.
  • Cao, B., Y. Wang, D. Wen, W. Liu, J. Wang, G. Fan, L. Ruan, B. Song, Y. Cai, M. Wei, et al. 2020. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. The New England Journal of Medicine 382 (19):1787–99. doi: 10.1056/nejmoa2001282.
  • Caramaschi, S., M. E. Kapp, S. E. Miller, R. Eisenberg, J. Johnson, G. Epperly, A. Maiorana, G. Silvestri, and G. A. Giannico. 2021. Histopathological findings and clinicopathologic correlation in COVID-19: A systematic review. Modern Pathology 34 (9):1614–33. doi: 10.1038/s41379-021-00814-w.
  • Ceccarelli, G., M. Marazzato, L. Celani, F. Lombardi, A. Piccirilli, M. Mancone, V. Trinchieri, F. Pugliese, C. M. Mastroianni, and G. d’Ettorre. 2021. Oxygen sparing effect of bacteriotherapy in Covid-19. Nutrients 13 (8):2898. doi: 10.3390/nu13082898.
  • Chen, Y., Q. Liu, and D. Guo. 2020. Emerging coronaviruses: Genome structure, replication, and pathogenesis. Journal of Medical Virology 92 (10):2249. doi: 10.1002/jmv.25681.
  • Chenchula, S., P. Karunakaran, S. Sharma, and M. Chavan. 2022. Current evidence on efficacy of COVID-19 booster dose vaccination against the omicron variant: A systematic review. Journal of Medical Virology 94 (7):2969–76. doi: 10.1002/jmv.27697.
  • Cheng, Q., J. Chen, Q. Jia, Z. Fang, and G. Zhao. 2021. Efficacy and safety of current medications for treating severe and non-severe COVID-19 patients: An updated network meta-analysis of randomized placebo-controlled trials. Aging 13 (18):21866–902. doi: 10.18632/aging.203522.
  • Chong, H.-X., N. A. A. Yusoff, Y.-Y. Hor, L.-C. Lew, M. H. Jaafar, S.-B. Choi, M. S. Yusoff, N. Wahid, M. F. I. Abdullah, N. Zakaria, et al. 2019. Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: A randomized, double-blind, placebo-controlled study. Journal of Dairy Science 102 (6):4783–97. doi: 10.3168/jds.2018-16103.
  • Collinson, S., A. Deans, A. Padua-Zamora, G. V. Gregorio, C. Li, L. F. Dans, and S. J. Allen, Cochrane Infectious Diseases Group. 2020. Probiotics for treating acute infectious diarrhoea. Cochrane Database of Systematic Reviews 2020 8:12. doi: 10.1002/14651858.CD003048.pub4.
  • d’Ettorre, G., G. Ceccarelli, M. Marazzato, G. Campagna, C. Pinacchio, F. Alessandri, F. Ruberto, G. Rossi, L. Celani, C. Scagnolari, et al. 2020. Challenges in the management of SARS-CoV2 infection: The role of oral bacteriotherapy as complementary therapeutic strategy to avoid the progression of COVID-19. Frontiers in Medicine 7 (July):389. doi: 10.3389/fmed.2020.00389.
  • Deng, J., F. Zhou, S. Ali, K. Heybati, W. Hou, E. Huang, and C. Y. Wong. 2021. Efficacy and safety of ivermectin for the treatment of COVID-19: A systematic review and meta-analysis. QJM: Monthly Journal of the Association of Physicians 114 (10):721–32. doi: 10.1093/qjmed/hcab247.
  • Fonollá, J., C. Gracián, J. A. Maldonado-Lobón, C. Romero, A. Bédmar, J. C. Carrillo, C. Martín-Castro, A. L. Cabrera, J. M. García-Curiel, C. Rodríguez, et al. 2019. Effects of Lactobacillus coryniformis K8 CECT5711 on the immune response to influenza vaccination and the assessment of common respiratory symptoms in elderly subjects: A randomized controlled trial. European Journal of Nutrition 58 (1):83–90. doi: 10.1007/s00394-017-1573-1.
  • Gutiérrez-Castrellón, P., T. Gandara-Martí, A. T. Abreu Y Abreu, C. D. Nieto-Rufino, E. López-Orduña, I. Jiménez-Escobar, C. Jiménez-Gutiérrez, G. López-Velazquez, and J. Espadaler-Mazo. 2022. Probiotic improves symptomatic and viral clearance in Covid19 outpatients: A randomized, quadruple-blinded, placebo-controlled trial. Gut Microbes 14 (1):1–16. doi: 10.1080/19490976.2021.2018899.
  • Herbison, P., J. Hay-Smith, and W. J. Gillespie. 2011. Meta-analyses of small numbers of trials often agree with longer-term results. Journal of Clinical Epidemiology 64 (2):145–53. doi: 10.1016/j.jclinepi.2010.02.017.
  • Higgins, J. P. T., J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, and V. A. Welch. 2020. Cochrane handbook for systematic reviews of interventions. Cochrane. Available in: https://training.cochrane.org/handbook.
  • Higgins, J. P. T., S. G. Thompson, J. J. Deeks, and D. G. Altman. 2003. Measuring inconsistency in meta-analyses. BMJ (Clinical Research ed.) 327 (7414):557–60. doi: 10.1136/bmj.327.7414.557.
  • Hu, J., Lin Zhang, W. Lin, W. Tang, and F. K. L. Chan. 2021. Review article: Probiotics, prebiotics and dietary approaches during COVID-19 pandemic. Trends Food Sci Technol Feb;108:187–196.
  • Huang, C., Y. Wang, X. Li, L. Ren, J. Zhao, Y. Hu, L. Zhang, G. Fan, J. Xu, X. Gu, et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet 395 (10223):497–506. doi: 10.1016/S0140-6736(20)30183-5.
  • Kageyama, Y., Y. Nishizaki, K. Aida, K. Yayama, T. Ebisui, T. Akiyama, and T. Nakamura. 2022. Lactobacillus plantarum induces innate cytokine responses that potentially provide a protective benefit against COVID-19: A single-arm, double-blind, prospective trial combined with an in vitro cytokine response assay. Experimental and Therapeutic Medicine 23 (1):20. doi: 10.3892/etm.2021.10942.
  • Kamel, A. M., M. S. Monem, N. A. Sharaf, N. Magdy, and S. F. Farid. 2022. Efficacy and safety of azithromycin in Covid-19 patients: A systematic review and meta-analysis of randomized clinical trials. Reviews in Medical Virology 32 (1):1–15. doi: 10.1002/rmv.2258.
  • Ke, E., and H. Zhang. 2020. Clinical effects of probiotics in ordinary-type COVID-19 patients with diarrhea. World Chinese Journal of Digestology 28 (17):834–8. doi: 10.11569/wcjd.v28.i17.834.
  • Li, Q., F. Cheng, Q. Xu, Y. Su, X. Cai, F. Zeng, and Y. Zhang. 2021. The role of probiotics in coronavirus disease-19 infection in Wuhan: A retrospective study of 311 severe patients. International Immunopharmacology 95 (June):107531. doi: 10.1016/j.intimp.2021.107531.
  • McFarland, L. V., C. T. Evans, and E. J. Goldstein. 2018. Strain-specificity and disease-specificity of probiotic efficacy: A systematic review and meta-analysis. Frontiers in Medicine 5 (May):124. doi: 10.3389/fmed.2018.00124.
  • Meskina, E. R., E. E. Tselipanova, M. K. Khadisova, L. A. Galkina, and T. V. Stashko. 2021. Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2. Part 1. Heating clinical displays period. Terapevticheskii Arkhiv 93 (4):456–64. doi: 10.26442/00403660.2021.04.200835.
  • Mirashrafi, S., A. R. Moravejolahkami, Z. B. Zehi, M. A. H. Kermani, N. Bahreini-Esfahani, M. Haratian, M. G. Dashti, and M. Pourhossein. 2021. The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment. Clinical Nutrition ESPEN 46 (October):1–8. doi: 10.1016/j.clnesp.2021.10.016.
  • Ouzzani, M., H. Hammady, Z. Fedorowicz, and A. Elmagarmid. 2016. Rayyan - A web and mobile app for systematic reviews. Systematic Reviews 5 (1):1–10. doi: 10.1186/s13643-016-0384-4.
  • Page, M. J., J. E. McKenzie, P. Bossuyt, I. Boutron, T. C. Hoffmann, C. D. Mulrow, and L. Shamseer. 2021. The Prisma 2020 statement: An updated guideline for reporting systematic reviews. Medicina Fluminensis 57 (4):444–465. doi: 10.21860/medflum2021_264903.
  • Pu, F., Y. Guo, M. Li, H. Zhu, S. Wang, X. Shen, M. He, C. Huang, and F. He. 2017. Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial. Clinical Interventions in Aging 12:1223–31. doi: 10.2147/CIA.S141518.
  • Rashidi, K., M. Darand, N. Garousi, A. Dehghani, and S. Alizadeh. 2021. Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials. Complementary Therapies in Medicine 63:102795. doi: 10.1016/j.ctim.2021.102795.
  • Rijkers, G. T., S. Bengmark, P. Enck, D. Haller, U. Herz, M. Kalliomaki, and S. Kudo. 2010. Guidance for substantiating the evidence for beneficial effects of probiotics: Current status and recommendations for future research. Journal of Nutrition 140 (3):671–6. doi: 10.3945/jn.109.113779.
  • Santagati, M., M. Scillato, N. Muscaridola, V. Metoldo, I. L. Mantia, and S. Stefani. 2015. Colonization, safety, and tolerability study of the streptococcus salivarius 24SMBc nasal spray for its application in upper respiratory tract infections. European Journal of Clinical Microbiology and Infectious Diseases. 34 (10):2075–80. doi: 10.1007/s10096-015-2454-2.
  • Shi, H. Y., X. Zhu, W. L. Li, J. W. Mak, S. H. Wong, S. T. Zhu, S. L. Guo, F. K. Chan, S. T. Zhang, and S. C. Ng. 2021. Modulation of gut microbiota protects against viral respiratory tract infections: A systematic review of animal and clinical studies. European Journal of Nutrition 60 (8):4151–74. doi: 10.1007/s00394-021-02519-x.
  • Sterne, J. A., M. A. Hernán, B. C. Reeves, J. Savović, N. D. Berkman, M. Viswanathan, D. Henry, D. G. Altman, M. T. Ansari, I. Boutron, et al. 2016. ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ (Clinical Research ed.) 355:i4919. doi: 10.1136/bmj.i4919.
  • Sterne, J. A. C., J. Savović, M. J. Page, R. G. Elbers, N. S. Blencowe, I. Boutron, C. J. Cates, H.-Y. Cheng, M. S. Corbett, S. M. Eldridge, et al. 2019. RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ (Clinical Research ed.) 366:l4898. doi: 10.1136/bmj.l4898.
  • Wang, B., T. Hylwka, M. Smieja, M. Surrette, D. M. Bowdish, and M. Loeb. 2018. Probiotics to prevent respiratory infections in nursing homes: A pilot randomized controlled trial. Journal of the American Geriatrics Society 66 (7):1346–52. doi: 10.1111/jgs.15396.
  • Wang, H., Y. Wang, C. Lu, L. Qiu, X. Song, H. Jia, D. Cui, and G. Zhang. 2021a. The efficacy of probiotics in patients with severe COVID-19. Annals of Palliative Medicine 10 (12):12374–80. doi: 10.21037/apm-21-3373.
  • Wang, Q., X. Lin, X. Xiang, W. Liu, Y. Fang, H. Chen, F. Tang, H. Guo, D. Chen, X. Hu, Q. Wu, B. Zhu, and J. Xia. 2021b. Oropharyngeal probiotic ENT-K12 prevents respiratory tract infections among frontline medical staff fighting against COVID-19: A pilot study. Frontiers in Bioengineering and Biotechnology 9 (June):646184–9. doi: 10.3389/fbioe.2021.646184.
  • World Health Organization. 2022a. Coronavirus. https://www.who.int/health-topics/coronavirus#tab=tab_1.
  • World Health Organization. 2022b. Tracking SARS-CoV-2 variants. https://www.who.int/activities/tracking-SARS-CoV-2-variants.
  • World Health Organization. 2022c. WHO coronavirus (COVID-19) dashboard | WHO coronavirus (COVID-19) dashboard with vaccination data. https://covid19.who.int/.
  • Wu, D., T. Wu, Q. Liu, and Z. Yang. 2020. The SARS-CoV-2 outbreak: What we know. International Journal of Infectious Diseases 94:44–8. doi: 10.1016/j.ijid.2020.03.004.
  • Zhang, H., J. Miao, M. Su, B. Y. Liu, and Z. Liu. 2021b. Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: A randomized clinical trial. Pharmaceutical Biology 59 (1):647–52. doi: 10.1080/13880209.2021.1929344.
  • Zhang, H., C. Yeh, Z. Jin, L. Ding, B. Y. Liu, L. Zhang, and H. K. Dannelly. 2018. Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate. Synthetic and Systems Biotechnology 3 (2):113–20. doi: 10.1016/j.synbio.2018.03.001.
  • Zhang, L., H. Han, X. Li, C. Chen, X. Xie, G. Su, S. Ye, C. Wang, Q. He, F. Wang, Wang, Z. J. Wu, and T.. Lai. 2021. Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19. Therapeutic Advances in Gastroenterology 14:17562848211035670–9. doi: 10.1177/17562848211035670.
  • Zhao, W., C. Peng, H. A. Sakandar, L.-Y. Kwok, and W. Zhang. 2021a. Meta-analysis: Randomized trials of lactobacillus plantarum on immune regulation over the last decades. Frontiers in Immunology 12 (March):1–8. doi: 10.3389/fimmu.2021.643420.
  • Zheng, J. 2020. SARS-CoV-2: An emerging coronavirus that causes a global threat. International Journal of Biological Sciences 16 (10):1678–85. doi: 10.7150/ijbs.45053.

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