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Matrix-associated mycotoxins in foods, cereals and feedstuffs: A review on occurrence, detection, transformation and future challenges

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References

  • Avantaggiato, G., R. De la Campa, J. D. Miller, and A. Visconti. 2003. Effects of muffin processing on fumonisins from C-14-labeled toxins produced in cultured corn kernels. Journal of Food Protection 66 (10):1873–1878. doi: 10.4315/0362-028x-66.10.1873.
  • Bergamini, E., D. Catellani, C. Dall’asta, G. Galaverna, A. Dossena, R. Marchelli, and M. Suman. 2010. Fate of Fusarium mycotoxins in the cereal product supply chain: The deoxynivalenol (DON) case within industrial bread-making technology. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 27 (5):677–687. doi: 10.1080/19440041003660117.
  • Berthiller, F., R. Krska, K. J. Domig, W. Kneifel, N. Juge, R. Schuhmacher, and G. Adam. 2011. Hydrolytic fate of deoxynivalenol-3-glucoside during digestion. Toxicology Letters 206 (3):264–267. doi: 10.1016/j.toxlet.2011.08.006.
  • Bertuzzi, T., A. Mulazzi, S. Rastelli, and A. Pietri. 2016. Hidden fumonisins: Simple and innovative extractions for their determination in maize and derived products. Food Analytical Methods 9 (7):1970–1979. doi: 10.1007/s12161-015-0377-2.
  • Biomin 2020. World mycotoxins survey.
  • Bittner, A., B. Cramer, and H. U. Humpf. 2013. Matrix binding of ochratoxin A during roasting. Journal of Agricultural and Food Chemistry 61 (51):12737–12743. doi: 10.1021/jf403984x
  • Bowles, D., E. K. Lim, B. Poppenberger, and F. E. Vaistij. 2006. Glycosyltransferases of lipophilic small molecules. Annual Review of Plant Biology 57:567–597. doi: 10.1146/annurev.­arplant.57.032905.105429.
  • Bryła, M., M. Roszko, K. Szymczyk, R. Jędrzejczak, and M. W. Obiedziński. 2016. Fumonisins and their masked forms in maize products. Food Control 59:619–627. doi: 10.1016/j.foodcont.2015.06.032.
  • Bryła, M., M. Roszko, K. Szymczyk, R. Jędrzejczak, E. Słowik, and M. W. Obiedziński. 2014. Effect of baking on reduction of free and hidden fumonisins in gluten-free bread. Journal of Agricultural and Food Chemistry 62 (42):10341–10347. doi: 10.1021/jf504077m
  • Bryła, M., A. Waśkiewicz, E. Ksieniewicz-Woźniak, K. Szymczyk, and R. Jędrzejczak. 2018. Modified fusarium mycotoxins in cereals and their products-metabolism, occurrence, and toxicity: An updated review. Molecules 23 (4):963. doi: 10.3390/molecules23040963.
  • Burns, T. D., M. E. Snook, R. T. Riley, and K. A. Voss. 2008. Fumonisin concentrations and in vivo toxicity of nixtamalized Fusarium verticillioides culture material: Evidence for fumonisin-matrix interactions. Food and Chemical Toxicology 46 (8):2841–2848. doi: 10.1016/j.fct.2008.05.017.
  • Chain, E. P. O. C. I. T. F., Knutsen, H.-K., J. Alexander, L. Barregård, M. Bignami, B. Brüschweiler, S. Ceccatelli, B. Cottrill, M. Dinovi, L. Edler, B. Grasl-Kraupp, et al. 2017a. Risks for animal health related to the presence of zearalenone and its modified forms in feed. EFSA Journal. European Food Safety Authority 15 (7):e04851. doi: 10.2903/j.efsa.2017.4851.
  • Chain, E. P. O. C. I. T. F., Knutsen, H. K., J. Alexander, L. Barregård, M. Bignami, B. Brüschweiler, S. Ceccatelli, B. Cottrill, M. Dinovi, B. Grasl-Kraupp, C. Hogstrand, EFSA Panel on Contaminants in the Food Chain (CONTAM), et al. 2017b. Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA Journal. European Food Safety Authority 15 (9):e04718. doi: 10.2903/j.efsa.2017.4718.
  • Cirlini, M., C. Dall’Asta, and G. Galaverna. 2012. Hyphenated chromatographic techniques for structural characterization and determination of masked mycotoxins. Journal of Chromatography. A 1255:145–152. doi: 10.1016/j.chroma.2012.02.057.
  • Dall’Asta, C., C. Falavigna, G. Galaverna, A. Dossena, and R. Marchelli. 2010. In vitro digestion assay for determination of hidden fumonisins in maize. Journal of Agricultural and Food Chemistry 58 (22):12042–12047. doi: 10.1021/jf103799q.
  • Dall’Asta, C., G. Galaverna, G. Aureli, A. Dossena, and R. Marchelli. 2008. A LC/MS/MS method for the simultaneous quantification of free and masked fumonisins in maize and maize-based products. World Mycotoxin Journal 1 (3):237–246. doi: 10.3920/WMJ2008.x040.
  • Dall’Asta, C., G. Galaverna, M. Mangia, S. Sforza, A. Dossena, and R. Marchelli. 2009a. Free and bound fumonisins in gluten-free food products. Molecular Nutrition & Food Research 53 (4):492–499. doi: 10.1002/mnfr.200800088.
  • Dall’Asta, C., M. Mangia, F. Berthiller, A. Molinelli, M. Sulyok, R. Schuhmacher, R. Krska, G. Galaverna, A. Dossena, and R. Marchelli. 2009b. Difficulties in fumonisin determination: The issue of hidden fumonisins. Analytical and Bioanalytical Chemistry 395 (5):1335–1345. doi: 10.1007/s00216-009-2933-3.
  • De Girolamo, A., V. M. T. Lattanzio, R. Schena, A. Visconti, and M. Pascale. 2016. Effect of alkaline cooking of maize on the content of fumonisins B-1 and B-2 and their hydrolysed forms. Food Chemistry 192:1083–1089. doi: 10.1016/j.foodchem.2015.07.059.
  • EFSA, Knutsen, H.-K., J. Alexander, L. Barregård, M. Bignami, B. Brüschweiler, S. Ceccatelli, B. Cottrill, M. Dinovi, L. Edler, B. Grasl-Kraupp, et al. 2018. Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed. EFSA Journal. European Food Safety Authority 16 (5):e05242. doi: 10.2903/j.efsa.2018.5242.
  • Arcella D., P. Gergelova M. L. Innocenti, and H. Steinkellner, European Food Safety, A. 2017. Human and animal dietary exposure to T-2 and HT-2 toxin. EFSA journal. European Food Safety Authority 15 (8):e04972. doi:10.2903/j.efsa.2017.4972.
  • Freire, L., and A. S. Sant’Ana. 2018. Modified mycotoxins: An updated review on their formation, detection, occurrence, and toxic effects. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 111:189–205. doi: 10.1016/j.fct.2017.11.021.
  • Gareis, M., J. Bauer, J. Thiem, G. Plank, S. Grabley, and B. Gedek. 1990. Cleavage of zearalenone-glycoside, a masked mycotoxin, during digestion in swine. Zentralblatt Fur Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 37 (3):236–240. doi: 10.1111/j.1439-0450.1990.tb01052.x.
  • Giorni, P., C. Dall’Asta, R. Gregori, M. Cirlini, G. Galaverna, and P. Battilani. 2015. Starch and thermal treatment, important factors in changing detectable fumonisins in maize post-harvest. Journal of Cereal Science 61:78–85. doi: 10.1016/j.jcs.2014.10.006.
  • Gorst-Allman, C. P., P. S. Steyn, R. Vleggaar, and C. J. Rabie. 1985. Structure elucidation of a novel trichothecene glycoside using h-1 and c-13 nuclear magnetic-resonance spectroscopy. Journal of the Chemical Society, Perkin Transactions 1 (7):1553–1555. doi: 10.1039/p19850001553.
  • Gruber-Dorninger, C., T. Jenkins, and G. Schatzmayr. 2019. Global mycotoxin occurrence in feed: A ten-year survey. Toxins (Basel) 11 (7):375. doi: 10.3390/toxins11070375.
  • Guo, L.-P., L. Hu, H.-Q. Zhu, M.-L. Ni, J. Yang, and C.-Z. Kang. 2020. Free and hidden fumonisins in hordei fructus germinatus and their transfer to the decoction. World Journal of Traditional Chinese Medicine 6 (1):106. doi: 10.4103/wjtcm.wjtcm_5_20.
  • Hu, L., H. Liu, J. Yang, C. Wang, Y. Wang, Y. Yang, and X. Chen. 2019. Free and hidden fumonisins in raw maize and maize-based products from China. Food Additives & Contaminants. Part B, Surveillance 12 (2):90–96. doi: 10.1080/19393210.2018.1564371.
  • Jouquand, C., V. Ducruet, and P. Lebail. 2006. Formation of amylose complexes with C6-aroma compounds in starch dispersions and its impact on retention. Food Chemistry 96 (3):461–470. doi: 10.1016/j.foodchem.2005.03.001.
  • Khaneghah, A. M., L. M. Martins, A. M. von Hertwig, R. Bertoldo, and A. S. Sant’Ana. 2018. Deoxynivalenol and its masked forms: Characteristics, incidence, control and fate during wheat and wheat based products processing - A review. Trends in Food Science & Technology 71:13–24. doi: 10.1016/j.tifs.2017.10.012.
  • Kim, E. K., P. M. Scott, and B. P. Lau. 2003. Hidden fumonisin in corn flakes. Food Additives and Contaminants 20 (2):161–169. doi: 10.1080/0265203021000035362.
  • Kim, E. K., P. M. Scott, B. P. Y. Lau, and D. A. Lewis. 2002. Extraction of fumonisins B-1, and B-2 from white rice flour and their stability in white rice flour, cornstarch, cornmeal, and glucose. Journal of Agricultural and Food Chemistry 50 (12):3614–3620. doi: 10.1021/jf020058s.
  • Kong, F., S. Kang, J. Zhang, L. Jiang, Y. Liu, M. Yang, X. Cao, Y. Zheng, J. Shao, and X. Yue. 2022. The non-covalent interactions between whey protein and various food functional ingredients. Food Chemistry 394:133455. doi: 10.1016/j.foodchem.2022.133455.
  • Kostelanska, M., Z. Dzuman, A. Malachova, I. Capouchova, E. Prokinova, A. Skerikova, and J. Hajslova. 2011. Effects of milling and baking technologies on levels of deoxynivalenol and its masked form deoxynivalenol-3-glucoside. Journal of Agricultural and Food Chemistry 59 (17):9303–9312. doi: 10.1021/jf202428f.
  • Kuchenbuch, H. S., B. Cramer, and H. U. Humpf. 2019. Matrix binding of T-2 toxin: Structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating. Mycotoxin Research 35 (3):261–270. doi: 10.1007/s12550-019-00350-2.
  • Leslie, J. F., A. Moretti, Á. Mesterházy, M. Ameye, K. Audenaert, P. K. Singh, F. Richard-Forget, S. N. Chulze, E. M. D. Ponte, A. Chala, et al. 2021. Key global actions for mycotoxin management in wheat and other small grains. Toxins 13 (10):725. doi: 10.3390/toxins13100725.
  • Lu, X., C. Shi, J. Zhu, Y. Li, and Q. Huang. 2019. Structure of starch-fatty acid complexes produced via hydrothermal treatment. Food Hydrocolloids. 88:58–67. doi: 10.1016/j.foodhyd.2018.09.034.
  • Lyagin, I, and E. Efremenko. 2019. Enzymes for detoxification of various mycotoxins: Origins and mechanisms of catalytic action. Molecules 24 (13):2362. doi: 10.3390/molecules24132362.
  • Massarolo, K. C., C. F. J. Ferreira, C. C. Collazzo, A. Bianchini, L. Kupski, and E. Badiale-Furlong. 2020. Resistant starch and hydrothermal treatment of cornmeal: Factors in aflatoxins and fumonisin B1 reduction and bioaccessibility. Food Control. 114:107274. doi: 10.1016/j.foodcont.2020.107274.
  • Massarolo, K. C., J. R. Mendoza, T. Verma, L. Kupski, E. Badiale-Furlong, and A. Bianchini. 2021. Fate of aflatoxins in cornmeal during single-screw extrusion: A bioaccessibility approach. LWT 138:110734. doi: 10.1016/j.lwt.2020.110734.
  • Matos, N., M. Moraes, A. Sartori, and S. Jacob. 2021. Optimization and validation of an analytical method for the determination of free and hidden fumonisins in corn and corn products by UHPLC-MS/MS. Food Analytical Methods 14 (8):1611–1624. doi: 10.1007/s12161-021-01984-8.
  • Mukunzi, D., J. D. Habimana, Z. Li, and X. Zou. 2022. Mycotoxins detection: View in the lens of molecularly imprinted polymer and nanoparticles. Critical Reviews in Food Science and Nutrition :1–35. doi: 10.1080/10408398.2022.2027338.
  • Oliveira, M. S., A. C. L. Diel, R. H. Rauber, F. P. Fontoura, A. Mallmann, P. Dilkin, and C. A. Mallmann. 2015. Free and hidden fumonisins in Brazilian raw maize samples. Food Control. 53:217–221. doi: 10.1016/j.foodcont.2014.12.038.
  • Park, J. W., P. M. Scott, B. P. Lau, and D. A. Lewis. 2004. Analysis of heat-processed corn foods for fumonisins and bound fumonisins. Food Additives and Contaminants 21 (12):1168–1178. doi: 10.1080/02652030400021873.
  • Plessis du, B., T. Regnier, S. Combrinck, P. Steenkamp, and H. Meyer. 2020. Investigation of fumonisin interaction with maize macrocomponents and its bioaccessibility from porridge using the dynamic tiny-TIM gastrointestinal model. Food Control. 113:107165. doi: 10.1016/j.foodcont.2020.107165.
  • Pok, P. S., V. A. Garcia Londono, S. P. Aransibia, S. Vicente, A. M. Pacin, and S. L. Resnik. 2020. Free and hidden fumonisins in Argentinean raw maize samples. World Mycotoxin Journal 13 (1):109–116. doi: 10.3920/wmj2019.2484.
  • Putseys, J. A., Lamberts, L. Delcour, and J. A. 2010. Amylose-inclusion complexes: Formation, identity and physico-chemical properties. Journal of Cereal Science 51 (3):238–247. doi: 10.1016/j.jcs.2010.01.011.
  • Rahimi, E., E. Sadeghi, S. Bohlouli, and F. Karami. 2018. Fates of deoxynivalenol and deoxynivalenol-3-glucoside from wheat flour to Iranian traditional breads. Food Control. 91:339–343. doi: 10.1016/j.foodcont.2018.04.014.
  • Rani, K. U., Prasada Rao, U. J. S. Leelavathi, K, and Haridas Rao, P. 2001. Distribution of enzymes in wheat flour mill streams. Journal of Cereal Science 34 (3):233–242. doi: 10.1006/jcrs.2000.0393.
  • Rychlik, M., H.-U. Humpf, D. Marko, S. Dänicke, A. Mally, F. Berthiller, H. Klaffke, and N. Lorenz. 2014. Proposal of a comprehensive definition of modified and other forms of mycotoxins including “masked” mycotoxins. Mycotoxin Research 30 (4):197–205. doi: 10.1007/s12550-014-0203-5.
  • Saenger, W. 1984. The structure of the blue starch-iodine complex. Naturwissenschaften 71 (1):31–36. doi: 10.1007/BF00365977.
  • Schaarschmidt, S, and C. Fauhl-Hassek. 2019. Mycotoxins during the processes of nixtamalization and tortilla production. Toxins (Basel) 11 (4):227. doi: 10.3390/toxins11040227.
  • Scott, P. M., Lawrence, G. A. Lombaert, and G. A. 1999. Studies on extraction of fumonisins from rice, corn-based foods and beans. Mycotoxin Research 15 (2):50–60. doi: 10.1007/bf02945215.
  • Seefelder, W., A. Knecht, and H. U. Humpf. 2003. Bound fumonisin B-1: Analysis of fumonisin-B-1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Agricultural and Food Chemistry 51 (18):5567–5573. doi: 10.1021/jf0344338.
  • Simsek, S., K. Burgess, K. L. Whitney, Y. Gu, and S. Y. Qian. 2012. Analysis of deoxynivalenol and deoxynivalenol-3-glucoside in wheat. Food Control. 26 (2):287–292. doi: 10.1016/j.foodcont.2012.01.056.
  • Singh, J, and A. Mehta. 2020. Rapid and sensitive detection of mycotoxins by advanced and emerging analytical methods: A review. Food Science & Nutrition 8 (5):2183–2204. doi: 10.1002/fsn3.1474.
  • Tan, H., H. Zhou, T. Guo, J. Li, C. Zhang, S. Wang, Y. Zhang, and L. Ma. 2022. Zein structure and its hidden zearalenone: Effect of zein extraction methods. Food Chemistry 374:131563. doi: 10.1016/j.foodchem.2021.131563.
  • Tan, H., H. Zhou, T. Guo, Y. Zhang, J. Li, C. Zhang, and L. Ma. 2021. Effect of temperature and pH on the conversion between free and hidden zearalenone in zein. Food Chemistry 360:130001. doi: 10.1016/j.foodchem.2021.130001.
  • Tan, H., H. Zhou, T. Guo, Y. Zhang, and L. Ma. 2021a. Integrated multi-spectroscopic and molecular modeling techniques to study the formation mechanism of hidden zearalenone in maize. Food Chemistry 351:129286. doi: 10.1016/j.foodchem.2021.129286.
  • Tan, H., H. Zhou, T. Guo, Y. Zhang, and L. Ma. 2021b. Zein-bound zearalenone: A hidden mycotoxin found in maize and maize-products. Food Control. 124:107903. doi: 10.1016/j.foodcont.2021.107903.
  • Tang, M, and L. Copeland. 2007. Analysis of complexes between lipids and wheat starch. Carbohydrate Polymers 67 (1):80–85. doi: 10.1016/j.carbpol.2006.04.016.
  • Tang, Z., F. Liu, F. Fang, X. Ding, Q. Han, Y. Tan, and C. Peng. 2022. Solid-phase extraction techniques based on nanomaterials for mycotoxin analysis: An overview for food and agricultural products. Journal of Separation Science 45 (13):2273–2300. doi: 10.1002/jssc.202200067.
  • Vidal, A., A. Ambrosio, V. Sanchis, A. J. Ramos, and S. Marin. 2016. Enzyme bread improvers affect the stability of deoxynivalenol and deoxynivalenol-3-glucoside during breadmaking. Food Chemistry 208:288–296. doi: 10.1016/j.foodchem.2016.04.003.
  • Vidal, A., S. Marin, H. Morales, A. J. Ramos, and V. Sanchis. 2014. The fate of deoxynivalenol and ochratoxin A during the breadmaking process, effects of sourdough use and bran content. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 68:53–60. doi: 10.1016/j.fct.2014.03.006.
  • Vidal, A., S. Marin, V. Sanchis, S. De Saeger, and M. De Boevre. 2018. Hydrolysers of modified mycotoxins in maize: Alpha-amylase and cellulase induce an underestimation of the total aflatoxin content. Food Chemistry 248:86–92. doi: 10.1016/j.foodchem.2017.12.057.
  • Vidal, A., H. Morales, V. Sanchis, A. J. Ramos, and S. Marín. 2014. Stability of DON and OTA during the breadmaking process and determination of process and performance criteria. Food Control 40:234–242. doi: 10.1016/j.foodcont.2013.11.044.
  • Vidal, A., V. Sanchis, A. J. Ramos, and S. Marin. 2017. Effect of xylanase and alpha-amylase on DON and its conjugates during the breadmaking process. Food Research International (Ottawa, Ont.) 101:139–147. doi: 10.1016/j.foodres.2017.08.021.
  • Voss, K. A., S. M. Poling, F. I. Meredith, C. W. Bacon, and D. S. Saunders. 2001. Fate of fumonisins during the production of fried tortilla chips. Journal of Agricultural and Food Chemistry 49 (6):3120–3126. doi: 10.1021/jf001165u.
  • Wan, J., B. Chen, and J. Rao. 2020. Occurrence and preventive strategies to control mycotoxins in cereal-based food. Comprehensive Reviews in Food Science and Food Safety 19 (3):928–953. doi: 10.1111/1541-4337.12546.
  • Xing, K.-Y., S. Shan, D.-F. Liu, and W.-H. Lai. 2020. Recent advances of lateral flow immunoassay for mycotoxins detection. TrAC Trends in Analytical Chemistry 133:116087. doi: 10.1016/j.trac.2020.116087.
  • Yang, Y., G. Li, D. Wu, J. Liu, X. Li, P. Luo, N. Hu, H. Wang, and Y. Wu. 2020. Recent advances on toxicity and determination methods of mycotoxins in foodstuffs. Trends in Food Science & Technology 96:233–252. doi: 10.1016/j.tifs.2019.12.021.
  • Zachariasova, M., M. Vaclavikova, O. Lacina, L. Vaclavik, and J. Hajslova. 2012. Deoxynivalenol oligoglycosides: New “masked” fusarium toxins occurring in malt, beer, and breadstuff. Journal of Agricultural and Food Chemistry 60 (36):9280–9291. doi: 10.1021/jf302069z.
  • Zhang, Z., D. Nie, K. Fan, J. Yang, W. Guo, J. Meng, Z. Zhao, and Z. Han. 2020. A systematic review of plant-conjugated masked mycotoxins: Occurrence, toxicology, and metabolism. Critical Reviews in Food Science and Nutrition 60 (9):1523–1537. doi: 10.1080/10408398.2019.1578944.
  • Zhou, B., P. Schwarz, G.-Q. He, J. Gillespie, and R. Horsley. 2008. Effect of enzyme pretreatments on the determination of deoxynivalenol in barley. Journal of the American Society of Brewing Chemists 66 (2):103–108. doi: 10.1094/asbcj-2008-0226-01.

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