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Review Articles

Exploiting lactic acid bacteria for colorectal cancer: a recent update

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References

  • Agah, S., A. M. Alizadeh, M. Mosavi, P. Ranji, H. Khavari-Daneshvar, F. Ghasemian, S. Bahmani, and A. Tavassoli. 2019. More protection of Lactobacillus acidophilus than Bifidobacterium bifidum probiotics on azoxymethane-induced mouse colon cancer. Probiotics and Antimicrobial Proteins 11 (3):857–64. doi: 10.1007/s12602-018-9425-8.
  • Ali, M. S., R. M. Hussein, Y. Gaber, O. A. Hammam, and M. A. Kandeil. 2019. Modulation of JNK-1/β-catenin signaling by Lactobacillus casei, inulin and their combination in 1, 2-dimethylhydrazine-induced colon cancer in mice. RSC Advances 9 (50):29368–83. doi: 10.1039/c9ra04388h.
  • Arima, K., R. Zhong, T. Ugai, M. Zhao, K. Haruki, N. Akimoto, M. C. Lau, K. Okadome, R. S. Mehta, J. P. Väyrynen, et al. 2022. Western-style diet, pks island-carrying Escherichia coli, and colorectal cancer: Analyses from two large prospective cohort studies. Gastroenterology 163 (4):862–74. doi: 10.1053/j.gastro.2022.06.054.
  • Arun, K. B., A. Madhavan, T. R. Reshmitha, S. Thomas, and P. Nisha. 2019. Short chain fatty acids enriched fermentation metabolites of soluble dietary fibre from Musa paradisiaca drives HT29 colon cancer cells to apoptosis. PloS One 14 (5):e0216604. doi: 10.1371/journal.pone.0216604.
  • Bai, X., H. Wei, W. Liu, O. O. Coker, H. Gou, C. Liu, L. Zhao, C. Li, Y. Zhou, G. Wang, et al. 2022. Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites. Gut Gutjnl 71 (12):2439–50. (2021):doi: 10.1136/gutjnl-2021-325021.
  • Barrubés, L., N. Babio, N. Becerra-Tomás, N. Rosique-Esteban, and J. Salas-Salvadó. 2019. Association between dairy product consumption and colorectal cancer risk in adults: A systematic review and meta-analysis of epidemiologic studies. Advances in Nutrition (Bethesda, Md.) 10 (suppl_2):S190–S211. doi: 10.1093/advances/nmy114.
  • Benito, I., I. J. Encío, F. I. Milagro, M. Alfaro, A. Martínez-Peñuela, M. Barajas, and F. Marzo. 2021. Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in combination with Quercetin inhibit colorectal cancer development in ApcMin/+ mice. International Journal of Molecular Sciences 22 (9):4906. doi: 10.3390/ijms22094906.
  • Berger, H., and T. F. Meyer. 2021. Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer. Cancer Cell 39 (11):1439–41. doi: 10.1016/j.ccell.2021.10.010.
  • Brown, J. C., C. Ma, Q. Shi, C. S. Fuchs, J. Meyer, D. Niedzwiecki, T. Zemla, F. Couture, P. Kuebler, P. Kumar, et al. 2022. Physical activity in stage III colon cancer: CALGB/SWOG 80702 (Alliance). Journal of Clinical Oncology 9:JCO2200171. doi: 10.1200/JCO.22.00171.
  • Burr, N. E., E. Derbyshire, J. Taylor, S. Whalley, V. Subramanian, P. J. Finan, M. D. Rutter, R. Valori, and E. J. A. Morris. 2019. Variation in post-colonoscopy colorectal cancer across colonoscopy providers in English National Health Service: Population based cohort study. BMJ (Clinical Research ed.) 367:l6090. doi: 10.1136/bmj.l6090.
  • Chen, L., B. Jiang, C. Zhong, J. Guo, L. Zhang, T. Mu, Q. Zhang, and X. Bi. 2018. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis 39 (3):471–81. doi: 10.1093/carcin/bgy009.
  • Chen, M., K. Zhong, J. Tan, M. Meng, C. M. Liu, B. Chen, C. Huang, H. L. X. Wong, Z. Bian, T. Su, et al. 2021a. Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer. Clinical and Translational Medicine 11 (11):e564.
  • Chen, Y., B. Yang, C. Stanton, R. P. Ross, J. Zhao, H. Zhang, and W. Chen. 2021b. Bifidobacterium pseudocatenulatum ameliorates DSS-induced colitis by maintaining intestinal mechanical barrier, blocking proinflammatory cytokines, inhibiting TLR4/NF-κB signaling, and altering gut microbiota. Journal of Agricultural and Food Chemistry 69 (5):1496–512. doi: 10.1021/acs.jafc.0c06329.
  • Chen, Y., Y. Jin, C. Stanton, R. P. Ross, Z. Wang, J. Zhao, H. Zhang, B. Yang, and W. Chen. 2020. Dose-response efficacy and mechanisms of orally administered CLA-producing Bifidobacterium breve CCFM683 on DSS-induced colitis in mice. Journal of Functional Foods 75:104245. doi: 10.1016/j.jff.2020.104245.
  • Cheng, E., F.-S. Ou, C. Ma, D. Spiegelman, S. Zhang, X. Zhou, T. M. Bainter, L. B. Saltz, D. Niedzwiecki, R. J. Mayer, et al. 2022. Diet- and lifestyle-based prediction models to estimate cancer recurrence and death in patients with stage III colon cancer (CALGB 89803/Alliance). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 40 (7):740–51. doi: 10.1200/JCO.21.01784.
  • Chung, Y., Y. Ryu, B. C. An, Y. S. Yoon, O. Choi, T. Y. Kim, J. Yoon, J. Y. Ahn, H. J. Park, S. K. Kwon, et al. 2021. A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota. Microbiome 9 (1):122. doi: 10.1186/s40168-021-01071-4.
  • Corrêa-Filho, L. C., M. Moldão-Martins, and V. D. Alves. 2019. Advances in the application of microcapsules as carriers of functional compounds for food products. Applied Sciences 9 (3):571. doi: 10.3390/app9030571.
  • Coutzac, C., J. M. Jouniaux, A. Paci, J. Schmidt, D. Mallardo, A. Seck, V. Asvatourian, L. Cassard, P. Saulnier, L. Lacroix, et al. 2020. Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer. Nature Communications 11 (1):2168. doi: 10.1038/s41467-020-16079-x.
  • Dachev, M., J. Bryndová, M. Jakubek, Z. Moučka, and M. Urban. 2021. The effects of conjugated linoleic acids on cancer. Processes 9 (3):454. doi: 10.3390/pr9030454.
  • Deepak, V., W. A. Sundar, S. R. K. Pandian, S. D. Sivasubramaniam, N. Hariharan, and K. Sundar. 2021. Exopolysaccharides from Lactobacillus acidophilus modulates the antioxidant status of 1,2-dimethyl hydrazine-induced colon cancer rat model. 3 Biotech 11 (5):225. doi: 10.1007/s13205-021-02784-x.
  • Dimitrakopoulou, V. I., K. K. Tsilidis, P. C. Haycock, N. L. Dimou, K. Al-Dabhani, R. M. Martin, S. J. Lewis, M. J. Gunter, A. Mondul, I. M. Shui, et al. 2017. Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study. BMJ (Clinical Research ed.) 359:j4761., doi: 10.1136/bmj.j4761.
  • Ding, D., H. Zhong, R. Liang, T. Lan, X. Zhu, S. Huang, Y. Wang, J. Shao, X. Shuai, and B. Wei. 2021. Multifunctional nanodrug mediates synergistic photodynamic therapy and MDSCs-targeting immunotherapy of colon cancer. Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 8 (14):e2100712. doi: 10.1002/advs.202100712.
  • Dong, Y., J. Zhu, M. Zhang, S. Ge, and L. Zhao. 2020. Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition. Applied Microbiology and Biotechnology 104 (17):7377–89. doi: 10.1007/s00253-020-10775-w.
  • El-Deeb, N. M., A. M. Yassin, L. A. Al-Madboly, and A. El-Hawiet. 2018. A novel purified Lactobacillus acidophilus 20079 exopolysaccharide, LA-EPS-20079, molecularly regulates both apoptotic and NF-κB inflammatory pathways in human colon cancer. Microbial Cell Factories 17 (1):29. doi: 10.1186/s12934-018-0877-z.
  • Fadaei, M., R. Amini, D. Dastan, H. Eslami, and A. Mahdavinezhad. 2022. The promising effect of peucedanum chenur chloroformic extract on prevention of human colorectal cancer progression by modulating miR-135b, miR-21, and APC genes. Journal of Gastrointestinal Cancer 53 (3):549–56. doi: 10.1007/s12029-021-00660-8.
  • Fahmy, C. A., A. M. Gamal-Eldeen, E. A. El-Hussieny, B. M. Raafat, N. S. Mehanna, R. M. Talaat, and M. T. Shaaban. 2019. Bifidobacterium longum suppresses murine colorectal cancer through the modulation of oncomirs and tumor suppressor mirnas. Nutrition and Cancer 71 (4):688–700. doi: 10.1080/01635581.2019.1577984.
  • Farvid, M. S., E. Sidahmed, N. D. Spence, K. Mante Angua, B. A. Rosner, and J. B. Barnett. 2021. Consumption of red meat and processed meat and cancer incidence: A systematic review and meta-analysis of prospective studies. European Journal of Epidemiology 36 (9):937–51. doi: 10.1007/s10654-021-00741-9.
  • Feng, T., and J. Wang. 2020. Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: A systematic review. Gut Microbes 12 (1):1801944. doi: 10.1080/19490976.2020.1801944.
  • Frakolaki, G., V. Giannou, E. Topakas, and C. Tzia. 2021. Effect of various encapsulating agents on the beads’ morphology and the viability of cells during BB-12 encapsulation through extrusion. Journal of Food Engineering 294:110423. doi: 10.1016/j.jfoodeng.2020.110423.
  • Frank, M. H., B. J. Wilson, J. S. Gold, and N. Y. Frank. 2021. Clinical implications of colorectal cancer stem cells in the age of single-cell omics and targeted therapies. Gastroenterology 160 (6):1947–60. doi: 10.1053/j.gastro.2020.12.080.
  • Franko, J., S. Raman, N. Krishnan, D. Frankova, M. C. Tee, R. Brahmbhatt, C. D. Goldman, and R. J. Weigel. 2019. Randomized trial of perioperative probiotics among patients undergoing major abdominal operation. Journal of the American College of Surgeons 229 (6):533–40.e1. doi: 10.1016/j.jamcollsurg.2019.09.002.
  • Gao, Z., B. Guo, R. Gao, Q. Zhu, W. Wu, and H. Qin. 2015. Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer. Molecular Medicine Reports 12 (4):6119–27. doi: 10.3892/mmr.2015.4124.
  • Ghanavati, R., A. Akbari, F. Mohammadi, P. Asadollahi, A. Javadi, M. Talebi, and M. Rohani. 2020b. Lactobacillus species inhibitory effect on colorectal cancer progression through modulating the Wnt/β-catenin signaling pathway. Molecular and Cellular Biochemistry 470 (1–2):1–13. doi: 10.1007/s11010-020-03740-8.
  • Ghanavati, R., F. Mohammadi, A. Javadi, Z. Shahosseini, M. Talebi, and M. Rohani. 2020a. The effects of a mixture of Lactobacillus species on colorectal tumor cells activity through modulation of Hes1 pathway. PharmaNutrition 13:100207. doi: 10.1016/j.phanu.2020.100207.
  • Golkhalkhali, B., R. Rajandram, A. S. Paliany, G. F. Ho, W. Z. Wan Ishak, C. S. Johari, and K. F. Chin. 2018. Strain-specific probiotic (microbial cell preparation) and omega-3 fatty acid in modulating quality of life and inflammatory markers in colorectal cancer patients: A randomized controlled trial. Asia-Pacific Journal of Clinical Oncology 14 (3):179–91. doi: 10.1111/ajco.12758.
  • Gómez-Guillén, M. C., and M. P. Montero. 2021. Enhancement of oral bioavailability of natural compounds and probiotics by mucoadhesive tailored biopolymer-based nanoparticles: A review. Food Hydrocolloids 118:106772. doi: 10.1016/j.foodhyd.2021.106772.
  • Guo, C., D. Guo, L. Fang, T. Sang, J. Wu, C. Guo, Y. Wang, Y. Wang, C. Chen, J. Chen, et al. 2021. Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon. Carbohydrate Polymers 267:118231. doi: 10.1016/j.carbpol.2021.118231.
  • Guo, Y. X., T. Zhang, J. J. Gao, X. X. Jiang, M. X. Tao, X. Q. Zeng, W. Zhen, and D. D. Pan. 2020. Lactobacillus acidophilus CICC 6074 inhibits growth and induces apoptosis in colorectal cancer cells in vitro and in HT-29 cells induced-mouse model. J Funct Foods 75:104290. doi: 10.1016/j.jff.2020.104290.
  • Herp, S., S. Brugiroux, D. Garzetti, D. Ring, L. M. Jochum, M. Beutler, C. Eberl, S. Hussain, S. Walter, R. G. Gerlach, et al. 2019. Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis. Cell Host & Microbe 25 (5):681–94.e8. doi: 10.1016/j.chom.2019.03.004.
  • Heydari, Z., M. Rahaie, A. M. Alizadeh, S. Agah, S. Khalighfard, and S. Bahmani. 2019. Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the expression of microRNAs 135b, 26b, 18a and 155, and their involving genes in mice colon cancer. Probiotics and Antimicrobial Proteins 11 (4):1155–62. doi: 10.1007/s12602-018-9478-8.
  • Hibberd, A. A., A. Lyra, A. C. Ouwehand, P. Rolny, H. Lindegren, L. Cedgård, and Y. Wettergren. 2017. Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention. BMJ Open Gastroenterology 4 (1):e000145. doi: 10.1136/bmjgast-2017-000145.
  • Huang, R. M., K. Feng, S. F. Li, M. H. Zong, H. Wu, and S. Y. Han. 2021. Enhanced survival of probiotics in the electrosprayed microcapsule by addition of fish oil. Journal of Food Engineering 307:110650. doi: 10.1016/j.jfoodeng.2021.110650.
  • Hullings, A. G., R. Sinha, L. M. Liao, N. D. Freedman, B. I. Graubard, and E. Loftfield. 2020. Whole grain and dietary fiber intake and risk of colorectal cancer in the NIH-AARP diet and health study cohort. The American Journal of Clinical Nutrition 112 (3):603–12. doi: 10.1093/ajcn/nqaa161.
  • Hur, J., S. A. Smith-Warner, E. B. Rimm, W. C. Willett, K. Wu, Y. Cao, and E. Giovannucci. 2021. Alcohol intake in early adulthood and risk of colorectal cancer: Three large prospective cohort studies of men and women in the United States. European Journal of Epidemiology 36 (3):325–33. doi: 10.1007/s10654-021-00723-x.
  • Huynh, J., D. Baloyan, D. Chisanga, W. Shi, M. O'Brien, S. Afshar-Sterle, M. Alorro, L. Pang, D. S. Williams, A. C. Parslow, et al. 2021. Host IL11 signaling suppresses CD4+ T cell-mediated antitumor responses to colon cancer in mice. Cancer Immunology Research 9 (7):735–47. doi: 10.1158/2326-6066.CIR-19-1023.
  • Janney, A., F. Powrie, and E. H. Mann. 2020. Host-microbiota maladaptation in colorectal cancer. Nature 585 (7826):509–17. doi: 10.1038/s41586-020-2729-3.
  • Kajino-Sakamoto, R., T. Fujishita, M. M. Taketo, and M. Aoki. 2021. Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. Oncogene 40 (2):408–20. doi: 10.1038/s41388-020-01541-3.
  • Kakaei, F., M. Shahrasbi, T. A. Kermani, S. Taheri, and K. Tarvirdizade. 2019. Assessment of probiotic effects on colorectal surgery complications: A double blinded, randomized clinical trial. Biomedical Research and Therapy 6 (3):3067–72. doi: 10.15419/bmrat.v6i3.529.
  • Kayama, H., R. Okumura, and K. Takeda. 2020. Interaction between the microbiota, epithelia, and immune cells in the intestine. Annual Review of Immunology 38:23–48. doi: 10.1146/annurev-immunol-070119-115104.
  • Keyhani, G., H. M. Hosseini, and A. Salimi. 2022. Effect of extracellular vesicles of Lactobacillus rhamnosus GG on the expression of CEA gene and protein released by colorectal cancer cells. Iranian Journal of Microbiology 14 (1):90–6.
  • Kim, H. J., J. An, and E. M. Ha. 2022. Lactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells. Journal of Microbiology (Seoul, Korea) 60 (1):100–17. doi: 10.1007/s12275-022-1533-1.
  • Kordahi, M. C., I. B. Stanaway, M. Avril, D. Chac, M. P. Blanc, B. Ross, C. Diener, S. Jain, P. McCleary, A. Parker, et al. 2021. Genomic and functional characterization of a mucosal symbiont involved in early-stage colorectal cancer. Cell Host & Microbe 29 (10):1589–98.e6. doi: 10.1016/j.chom.2021.08.013.
  • Kotzampassi, K., G. Stavrou, G. Damoraki, M. Georgitsi, G. Basdanis, G. Tsaousi, and E. J. Giamarellos-Bourboulis. 2015. Giamarellos-Bourboulis. A four-probiotics regimen reduces postoperative complications after colorectal surgery: A randomized, double-blind, placebo-controlled study. World Journal of Surgery 39 (11):2776–83. doi: 10.1007/s00268-015-3071-z.
  • Kuhn, T., M. Koch, and G. Fuhrmann. 2020. Probiomimetics-novel Lactobacillus-mimicking microparticles show anti-Inflammatory and barrier-protecting effects in gastrointestinal models. Small (Weinheim an Der Bergstrasse, Germany) 16 (40):e2003158. doi: 10.1002/smll.202003158.
  • Lee, J. Y., S. H. Chu, J. Y. Jeon, M. K. Lee, J. H. Park, D. C. Lee, J. W. Lee, and N. K. Kim. 2014. Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: A double-blind, randomized, placebo-controlled trial. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 46 (12):1126–32. doi: 10.1016/j.dld.2014.09.004.
  • Liang, W., X. Peng, Q. Li, P. Wang, P. Lv, Q. Song, S. She, S. Huang, K. Chen, W. Gong, et al. 2020. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis. Nature Communications 11 (1):5912. doi: 10.1038/s41467-020-19691-z.
  • Lipan, L., B. Rusu, E. Sendra, F. Hernández, L. Vázquez-Araújo, D. C. Vodnar, and Á. A. Carbonell-Barrachina. 2020. Spray drying and storage of probiotic-enriched almond milk: Probiotic survival and physicochemical properties. Journal of the Science of Food and Agriculture 100 (9):3697–708. doi: 10.1002/jsfa.10409.
  • Liu, T., D. Liu, S. Guan, and M. Dong. 2021a. Diagnostic role of circulating MiR-21 in colorectal cancer: A update meta-analysis. Annals of Medicine 53 (1):87–102. doi: 10.1080/07853890.2020.1828617.
  • Liu, W., X. Zhang, H. Xu, S. Li, H. C.-H. Lau, Q. Chen, B. Zhang, L. Zhao, H. Chen, J. J.-Y. Sung, et al. 2021b. Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis. Gastroenterology 160 (7):2395–408. doi: 10.1053/j.gastro.2021.02.020.
  • Liu, Z. H., M. J. Huang, X. W. Zhang, L. Wang, N. Q. Huang, H. Peng, P. Lan, J. S. Peng, Z. Yang, Y. Xia, et al. 2013. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: A double-center and double-blind randomized clinical trial. The American Journal of Clinical Nutrition 97 (1):117–26. doi: 10.3945/ajcn.112.040949.
  • Ma, F., Y. Song, M. Sun, A. Wang, S. Jiang, G. Mu, and Y. Tuo. 2021. Exopolysaccharide produced by Lactiplantibacillus plantarum-12 alleviates intestinal inflammation and colon cancer symptoms by modulating the gut microbiome and metabolites of C57BL/6 mice treated by azoxymethane/dextran sulfate sodium salt. Foods 10 (12):3060. doi: 10.3390/foods10123060.
  • Maleki, D., A. Homayouni, L. Khalili, and B. Golkhalkhali. 2015. Probiotics, prebiotics, and synbiotics: Bioactive foods in health promotion, 781–91. Academic Press. doi: 10.1016/B978-0-12-802189-7.00059-9.
  • Malik, A., D. Sharma, R. K. S. Malireddi, C. S. Guy, T. C. Chang, S. R. Olsen, G. Neale, P. Vogel, and T. D. Kanneganti. 2018. SYK-CARD9 signaling axis promotes gut fungi-mediated inflammasome activation to restrict colitis and colon cancer. Immunity 49 (3):515–30.e5. doi: 10.1016/j.immuni.2018.08.024.
  • Mangell, P., H. Thorlacius, I. Syk, S. Ahrné, G. Molin, C. Olsson, and B. Jeppsson. 2012. Lactobacillus plantarum 299v does not reduce enteric bacteria or bacterial translocation in patients undergoing colon resection. Digestive Diseases and Sciences 57 (7):1915–24. doi: 10.1007/s10620-012-2102-y.
  • Masalmeh, R. H. A., F. Taglini, C. Rubio-Ramon, K. I. Musialik, J. Higham, H. Davidson-Smith, I. Kafetzopoulos, K. P. Pawlicka, H. M. Finan, R. Clark, et al. 2021. De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands. Nature Communications 12 (1):694. doi: 10.1038/s41467-020-20716-w.
  • Mendes, M. C. S., D. S. Paulino, S. R. Brambilla, J. A. Camargo, G. F. Persinoti, and J. B. C. Carvalheira. 2018. Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice. World Journal of Gastroenterology 24 (18):1995–2008. doi: 10.3748/wjg.v24.i18.1995.
  • Mezzano, G., A. Juanola, A. Cardenas, E. Mezey, J. P. Hamilton, E. Pose, I. Graupera, P. Ginès, E. Solà, and R. Hernaez. 2022. Global burden of disease: Acute-on-chronic liver failure, a systematic review and meta-analysis. Gut 71 (1):148–55. doi: 10.1136/gutjnl-2020-322161.
  • Mi, H., Y. Dong, B. Zhang, H. Wang, C. C. K. Peter, P. Gao, H. Fu, and Y. Gao. 2017. Bifidobacterium infantis ameliorates chemotherapy-induced intestinal mucositis via regulating T cell immunity in colorectal cancer rats. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 42 (6):2330–41. doi: 10.1159/000480005.
  • Mizuta, M., I. Endo, S. Yamamoto, H. Inokawa, M. Kubo, T. Udaka, O. Sogabe, H. Maeda, K. Shirakawa, E. Okazaki, et al. 2016. Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: A prospective, randomized clinical trial. Bioscience of Microbiota, Food and Health 35 (2):77–87. doi: 10.12938/bmfh.2015-017.
  • Nakatsu, G., H. Zhou, W. K. K. Wu, S. H. Wong, O. O. Coker, Z. Dai, X. Li, C. H. Szeto, N. Sugimura, T. Y. Lam, et al. 2018. Alterations in enteric virome are associated with colorectal cancer and survival outcomes. Gastroenterology 155 (2):529–41.e5. doi: 10.1053/j.gastro.2018.04.018.
  • Oh, N. S., J. Y. Lee, Y. T. Kim, S. H. Kim, and J. H. Lee. 2020. Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer. Gut Microbes 12 (1):1785803. doi: 10.1080/19490976.2020.1785803.
  • Orange, S. T., A. R. Jordan, A. Odell, O. Kavanagh, K. M. Hicks, T. Eaglen, S. Todryk, and J. M. Saxton. 2022. Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage. International Journal of Cancer 151 (2):265–74. doi: 10.1002/ijc.33982.
  • Osman, A., B. Yan, Y. Li, K. D. Pavelko, J. Quandt, A. Saadalla, M. P. Singh, M. Kazemian, F. Gounari, and K. Khazaie. 2021. TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer. Nature Immunology 22 (9):1152–62. doi: 10.1038/s41590-021-00987-1.
  • Oster, P., L. Vaillant, E. Riva, B. McMillan, C. Begka, C. Truntzer, C. Richard, M. M. Leblond, M. Messaoudene, E. Machremi, et al. 2022. Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies. Gut 71 (3):457–66. doi: 10.1136/gutjnl-2020-323392.
  • Peng, M., Z. Tabashsum, M. Anderson, A. Truong, A. K. Houser, J. Padilla, A. Akmel, J. Bhatti, S. O. Rahaman, and D. Biswas. 2020. Effectiveness of probiotics, prebiotics, and prebiotic-like components in common functional foods. Comprehensive Reviews in Food Science and Food Safety 19 (4):1908–33. doi: 10.1111/1541-4337.12565.
  • Prizment, A. E., C. Staley, G. C. Onyeaghala, S. Vivek, B. Thyagarajan, R. J. Straka, R. T. Demmer, D. Knights, K. A. Meyer, A. Shaukat, et al. 2020. Randomised clinical study: Oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk. Alimentary Pharmacology & Therapeutics 52 (6):976–87. doi: 10.1111/apt.16013.
  • Pujo, J., C. Petitfils, P. L. Faouder, V. Eeckhaut, G. Payros, S. Maurel, T. Perez-Berezo, M. Van Hul, F. Barreau, C. Blanpied, et al. 2021. Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis. Gut 70 (6):1088–97. doi: 10.1136/gutjnl-2020-321173.
  • Quintana, G., M. G. Simões, A. Hugo, P. Alves, P. Ferreira, E. Gerbino, P. N. Simões, and A. Gómez-Zavaglia. 2017. Layer-by-layer encapsulation of Lactobacillus delbrueckii subsp. Bulgaricus using block-copolymers of poly (acrylic acid) and pluronic for safe release in gastro-intestinal conditions. Journal of Functional Foods 35:408–17. doi: 10.1016/j.jff.2017.06.007.
  • Rabiei, M., G. Zarrini, and M. Mahdavi. 2020. Lactobacillus casei UT1 isolated from northwest of Iran traditional curd exerts anti-proliferative and apoptosis inducing effects in human colorectal tumor HCT 116 cells. Advanced Pharmaceutical Bulletin 10 (1):125–9. doi: 10.15171/apb.2020.016.
  • Raddatz, G. C., G. Poletto, C. Deus, C. F. Codevilla, A. J. Cichoski, E. Jacob-Lopes, E. I. Muller, E. M. M. Flores, E. A. Esmerino, and C. R. de Menezes. 2020. Use of prebiotic sources to increase probiotic viability in pectin microparticles obtained by emulsification/internal gelation followed by freeze-drying. Food Research International (Ottawa, Ont.) 130:108902. doi: 10.1016/j.foodres.2019.108902.
  • Randon, G., R. Yaeger, J. F. Hechtman, P. Manca, G. Fucà, H. Walch, J. Lee, E. Élez, J. Seligmann, B. Mussolin, et al. 2021. EGFR amplification in metastatic colorectal cancer. Journal of the National Cancer Institute 113 (11):1561–9. doi: 10.1093/jnci/djab069.
  • Ren, Q., B. Yang, G. Zhu, S. Wang, C. Fu, H. Zhang, R. P. Ross, C. Stanton, H. Chen, and W. Chen. 2020. Antiproliferation activity and mechanism of c9, t11, c15-CLNA and t9, t11, c15-CLNA from Lactobacillus plantarum ZS2058 on colon cancer cells. Molecules 25 (5):1225. doi: 10.3390/molecules25051225.
  • Round, J. L., and N. W. Palm. 2018. Causal effects of the microbiota on immune-mediated diseases. Science Immunology 3 (20):eaao1603.
  • Rubinstein, M. R., J. E. Baik, S. M. Lagana, R. P. Han, W. J. Raab, D. Sahoo, P. Dalerba, T. C. Wang, and Y. W. Han. 2019. Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1. EMBO Reports 20 (4):e47638. doi: 10.15252/embr.201847638.
  • Saadat, Y. R., B. P. Gargari, A. Shahabi, Y. Nami, and A. Y. Khosroushahi. 2020. Prophylactic role of Lactobacillus Paracasei exopolysaccharides on colon cancer cells through apoptosis not ferroptosis. Pharmaceutical Sciences 27 (2):251–61. doi: 10.34172/PS.2020.39.
  • Sadahiro, S., T. Suzuki, A. Tanaka, K. Okada, H. Kamata, T. Ozaki, and Y. Koga. 2014. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial. Surgery 155 (3):493–503. doi: 10.1016/j.surg.2013.06.002.
  • Schmidt, E. M., S. Lamprecht, C. Blaj, C. Schaaf, S. Krebs, H. Blum, H. Hermeking, A. Jung, T. Kirchner, and D. Horst. 2018. Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer. The Journal of Experimental Medicine 215 (6):1693–708. doi: 10.1084/jem.20171455.
  • Schmitt, M., and F. R. Greten. 2021. The inflammatory pathogenesis of colorectal cancer. Nature Reviews Immunology 21 (10):653–67. doi: 10.1038/s41577-021-00534-x.
  • Shao, X., S. Sun, Y. Zhou, H. Wang, Y. Yu, T. Hu, Y. Yao, and C. Zhou. 2021. Bacteroides fragilis restricts colitis-associated cancer via negative regulation of the NLRP3 axis. Cancer Letters 523:170–81. doi: 10.1016/j.canlet.2021.10.002.
  • Sharma, M., D. Chandel, and G. Shukla. 2020. Antigenotoxicity and cytotoxic potentials of metabiotics extracted from isolated probiotic, Lactobacillus rhamnosus MD 14 on Caco-2 and HT-29 human colon cancer cells. Nutrition and Cancer 72 (1):110–9. doi: 10.1080/01635581.2019.1615514.
  • Song, H., W. Wang, B. Shen, H. Jia, Z. Hou, P. Chen, and Y. Sun. 2018. Pretreatment with probiotic Bifico ameliorates colitis-associated cancer in mice: Transcriptome and gut flora profiling. Cancer Science 109 (3):666–77. doi: 10.1111/cas.13497.
  • Spanogiannopoulos, P., E. N. Bess, R. N. Carmody, and P. J. Turnbaugh. 2016. Turnbaugh. The microbial pharmacists within us: A metagenomic view of xenobiotic metabolism. Nature Reviews Microbiology 14 (5):273–87. doi: 10.1038/nrmicro.2016.17.
  • Sugimura, N., Q. Li, E. S. H. Chu, H. C. H. Lau, W. Fong, W. Liu, C. Liang, G. Nakatsu, A. C. Y. Su, O. O. Coker, et al. 2021. Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis. Gut 71 (10):2011–21. doi: 10.1136/gutjnl-2020-323951.
  • Sun, M., W. Liu, Y. Song, Y. Tuo, G. Mu, and F. Ma. 2021. The effects of Lactobacillus plantarum-12 crude exopolysaccharides on the cell proliferation and apoptosis of human colon cancer (HT-29) cells. Probiotics and Antimicrobial Proteins 13 (2):413–21. doi: 10.1007/s12602-020-09699-8.
  • Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 71 (3):209–49. doi: 10.3322/caac.21660.
  • Tan, C. K., S. Said, R. Rajandram, Z. Wang, A. C. Roslani, and K. F. Chin. 2016. Pre-surgical administration of microbial cell preparation in colorectal cancer patients: A randomized controlled trial. World Journal of Surgery 40 (8):1985–92. doi: 10.1007/s00268-016-3499-9.
  • Tao, J., S. Li, R. Y. Gan, C. N. Zhao, X. Meng, and H. B. Li. 2020. Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action. Critical Reviews in Food Science and Nutrition 60 (6):1025–37. doi: 10.1080/10408398.2018.1555789.
  • Tao, J., Y. Li, S. Li, and H. B. Li. 2018. Plant foods for the prevention and management of colon cancer. Journal of Functional Foods 42:95–110. doi: 10.1016/j.jff.2017.12.064.
  • Taylor, J. C., X. Gao, J. Xu, M. Holder, J. Petrosino, R. Kumar, W. Liu, M. Höök, C. Mackenzie, A. Hillhouse, et al. 2021. A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors. PLoS Pathogens 17 (1):e1009182. doi: 10.1371/journal.ppat.1009182.
  • Ternes, D., M. Tsenkova, V. I. Pozdeev, M. Meyers, E. Koncina, S. Atatri, M. Schmitz, J. Karta, M. Schmoetten, A. Heinken, et al. 2022. The gut microbial metabolite formate exacerbates colorectal cancer progression. Nature Metabolism 4 (4):458–75. doi: 10.1038/s42255-022-00558-0.
  • Theodoropoulos, G. E., N. A. Memos, K. Peitsidou, T. Karantanos, B. G. Spyropoulos, and G. Zografos. 2016. Synbiotics and gastrointestinal function-related quality of life after elective colorectal cancer resection. Annals of Gastroenterology 29 (1):56–62.
  • Vallès, X., M. H. Alonso, J. F. López-Caleya, V. Díez-Obrero, T. Dierssen-Sotos, V. Lope, A. Molina-Barceló, M. D. Chirlaque, J. J. Jiménez-Moleón, G. Fernández Tardón, et al. 2018. Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study. Environment International 121 (1):428–34. doi: 10.1016/j.envint.2018.09.030.
  • Verma, A., and G. Shukla. 2013. Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats. Nutrition and Cancer 65 (1):84–91. doi: 10.1080/01635581.2013.741746.
  • Walia, S., R. Kamal, D. K. Dhawan, and S. S. Kanwar. 2018. Chemoprevention by probiotics during 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats. Digestive Diseases and Sciences 63 (4):900–9. doi: 10.1007/s10620-018-4949-z.
  • Wang, R., M. Moniruzzaman, K. Y. Wong, P. Wiid, A. Harding, R. Giri, W. H. Tong, J. Creagh, J. Begun, M. A. McGuckin, et al. 2021. Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut Microbes 13 (1):1–18.
  • Wang, T., J. Xu, Y. Xu, J. Xiao, N. Bi, X. Gu, and H. L. Wang. 2022b. Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex. Cell Reports 38 (10):110478. doi: 10.1016/j.celrep.2022.110478.
  • Wang, T., L. Zhang, P. Wang, Y. Liu, G. Wang, Y. Shan, Y. Yi, Y. Zhou, B. Liu, X. Wang, et al. 2022a. Lactobacillus coryniformis MXJ32 administration ameliorates azoxymethane/dextran sulfate sodium-induced colitis-associated colorectal cancer via reshaping intestinal microenvironment and alleviating inflammatory response. European Journal of Nutrition 61 (1):85–99. doi: 10.1007/s00394-021-02627-8.
  • Wong, S. H., and J. Yu. 2019. Gut microbiota in colorectal cancer: Mechanisms of action and clinical applications. Nature Reviews Gastroenterology & Hepatology 16 (11):690–704. doi: 10.1038/s41575-019-0209-8.
  • Wu, H., S. Xie, J. Miao, Y. Li, Z. Wang, M. Wang, and Q. Yu. 2020. Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa. Gut Microbes 11 (4):997–1014. doi: 10.1080/19490976.2020.1734423.
  • Wunderlich, C. M., P. J. Ackermann, A. L. Ostermann, P. Adams-Quack, M. C. Vogt, M. L. Tran, A. Nikolajev, A. Waisman, C. Garbers, S. Theurich, et al. 2018. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nature Communications 9 (1):1646. doi: 10.1038/s41467-018-03773-0.
  • Xi, Y., and P. Xu. 2021. Global colorectal cancer burden in 2020 and projections to 2040. Translational Oncology 14 (10):101174. doi: 10.1016/j.tranon.2021.101174.
  • Xiao, L., X. Ge, L. Yang, X. Chen, Q. Xu, X. Rui, X. Fan, L. Feng, Q. Zhang, M. Dong, et al. 2020. Anticancer potential of an exopolysaccharide from Lactobacillus helveticus MB2-1 on human colon cancer HT-29 cells via apoptosis induction. Food & Function 11 (11):10170–81. doi: 10.1039/d0fo01345e.
  • Xing, C., M. Wang, A. A. Ajibade, P. Tan, C. Fu, L. Chen, M. Zhu, Z. Z. Hao, J. Chu, X. Yu, et al. 2021. Microbiota regulate innate immune signaling and protective immunity against cancer. Cell Host & Microbe 29 (6):959–74.e7. doi: 10.1016/j.chom.2021.03.016.
  • Xiong, R. G., D. D. Zhou, S. X. Wu, S. Y. Huang, A. Saimaiti, Z. J. Yang, A. Shang, C. N. Zhao, R. Y. Gan, and H. B. Li. 2022. Health benefits and side effects of short-chain fatty acids. Foods 11 (18):2863. doi: 10.3390/foods11182863.
  • Yang, Y., L. Li, C. Xu, Y. Wang, Z. Wang, M. Chen, Z. Jiang, J. Pan, C. Yang, X. Li, et al. 2020. Cross-talk between the gut microbiota and monocyte-like macrophages mediates an inflammatory response to promote colitis-associated tumourigenesis. Gut 70 (8):1495–506. doi: 10.1136/gutjnl-2020-320777.
  • Yang, Y., Y. Xia, H. Chen, L. Hong, J. Feng, J. Yang, Z. Yang, C. Shi, W. Wu, R. Gao, et al. 2016. The effect of perioperative probiotics treatment for colorectal cancer: Short-term outcomes of a randomized controlled trial. Oncotarget 7 (7):8432–40. doi: 10.18632/oncotarget.7045.
  • Yin, K., J. Lee, Z. Liu, H. Kim, D. R. Martin, D. Wu, M. Liu, and X. Xue. 2021. Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production. Cell Death and Differentiation 28 (8):2421–35. doi: 10.1038/s41418-021-00760-9.
  • Yu, H., W. Liu, D. Li, C. Liu, Z. Feng, and B. Jiang. 2020. Targeting Delivery System for Targeting delivery system for Lactobacillus plantarum based on functionalized electrospun nanofibers. Polymers 12 (7):1565. doi: 10.3390/polym12071565.
  • Yue, Y. C., B. Y. Yang, J. Lu, S. W. Zhang, L. Liu, K. Nassar, X. X. Xu, X. Y. Pang, and J. P. Lv. 2020a. Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway. Microbial Cell Factories 19 (1):213. doi: 10.1186/s12934-020-01466-2.
  • Yue, Y., K. Ye, J. Lu, X. Wang, S. Zhang, L. Liu, B. Yang, K. Nassar, X. Xu, X. Pang, et al. 2020b. Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 127:110159. doi: 10.1016/j.biopha.2020.110159.
  • Zagato, E., C. Pozzi, A. Bertocchi, T. Schioppa, F. Saccheri, S. Guglietta, B. Fosso, L. Melocchi, G. Nizzoli, J. Troisi, et al. 2020. Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth. Nature Microbiology 5 (3):511–24. doi: 10.1038/s41564-019-0649-5.
  • Zaharuddin, L., N. M. Mokhtar, K. N. Muhammad Nawawi, and R. A. Raja Ali. 2019. A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer. BMC Gastroenterology 19 (1):131. doi: 10.1186/s12876-019-1047-4.
  • Zhang, J. W., P. Du, J. Gao, B. R. Yang, W. J. Fang, and C. M. Ying. 2012. Preoperative probiotics decrease postoperative infectious complications of colorectal cancer. The American Journal of the Medical Sciences 343 (3):199–205. doi: 10.1097/MAJ.0b013e31823aace6.
  • Zhang, T., D. Pan, Y. Yang, X. Jiang, J. Zhang, X. Zeng, Z. Wu, Y. Sun, and Y. Guo. 2020. Effect of Lactobacillus acidophilus CICC 6074 S-layer protein on colon cancer HT-29 cell proliferation and apoptosis. Journal of Agricultural and Food Chemistry 68 (9):2639–47. doi: 10.1021/acs.jafc.9b06909.
  • Zheng, D. W., R. Q. Li, J. X. An, T. Q. Xie, Z. Y. Han, R. Xu, Y. Fang, and X. Z. Zhang. 2020. Prebiotics-encapsulated probiotic spores regulate gut microbiota and suppress colon cancer. Advanced Materials (Deerfield Beach, Fla.) 32 (45):e2004529. doi: 10.1002/adma.202004529.
  • Zhu, J., C. Zhu, S. Ge, M. Zhang, L. Jiang, J. Cui, and F. Ren. 2014. Lactobacillus salivarius Ren prevent the early colorectal carcinogenesis in 1, 2-dimethylhydrazine-induced rat model. Journal of Applied Microbiology 117 (1):208–16. doi: 10.1111/jam.12499.

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