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Systematic Review

Can habitual tea drinking be an effective approach against age-related neurodegenerative cognitive disorders: A systematic review and meta-analysis of epidemiological evidence

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References

  • Ali, B., Q. M. S. Jamal, S. Shams, N. A. Al-Wabel, M. U. Siddiqui, M. A. Alzohairy, M. A. A. Karaawi, K. Kumar Kesari, G. Mushtaq, and M. A. Kamal. 2016. In silico analysis of green tea polyphenols as inhibitors of AChE and BChE enzymes in Alzheimer’s disease treatment. CNS & Neurological Disorders Drug Targets 15 (5):624–8.
  • An, R., G. Liu, N. Khan, H. Yan, and Y. Wang. 2019. Dietary habits and cognitive impairment risk among oldest-old Chinese. The Journals of Gerontology: Series B 74 (3):474–83. doi: 10.1093/geronb/gbw170.
  • Arab, L., F. Khan, and H. Lam. 2013. Epidemiologic evidence of a relationship between tea, coffee, or caffeine consumption and cognitive decline. Advances in Nutrition (Bethesda, MD) 4 (1):115–22. doi: 10.3945/an.112.002717.
  • Baba, Y., S. Inagaki, S. Nakagawa, T. Kaneko, M. Kobayashi, and T. Takihara. 2020. Effect of daily intake of green tea catechins on cognitive function in middle-aged and older subjects: A randomized, placebo-controlled study. Molecules 25 (18):4265. doi: 10.3390/molecules25184265.
  • Baba, Y., S. Inagaki, S. Nakagawa, T. Kaneko, M. Kobayashi, and T. Takihara. 2021. Effects of L-theanine on cognitive function in middle-aged and older subjects: A randomized placebo-controlled study. Journal of Medicinal Food 24 (4):333–41. doi: 10.1089/jmf.2020.4803.
  • Bahorun, T., V. Neergheen-Bhujun, N. A. Toolsee, J. Somanah, A. Luximon-Ramma, and O. I. Aruoma. 2013. Bioactive phytophenolics and antioxidant functions of aqueous and organic tea extracts. Tea in Health and Disease Prevention:361–74.
  • Barnham, K. J., and A. I. Bush. 2014. Biological metals and metal-targeting compounds in major neurodegenerative diseases. Chemical Society Reviews 43 (19):6727–49. doi: 10.1039/c4cs00138a.
  • Biasibetti, R., A. C. Tramontina, A. P. Costa, M. F. Dutra, A. Quincozes-Santos, P. Nardin, C. L. Bernardi, K. M. Wartchow, P. S. Lunardi, and C.-A. Gonçalves. 2013. Green tea (−) epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia. Behavioural Brain Research 236:186–93. doi: 10.1016/j.bbr.2012.08.039.
  • Camfield, D. A., C. Stough, J. Farrimond, and A. B. Scholey. 2014. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: A systematic review and meta-analysis. Nutrition Reviews 72 (8):507–22. doi: 10.1111/nure.12120.
  • Chen, X., Y. Huang, and H. Cheng. 2012. Lower intake of vegetables and legumes associated with cognitive decline among illiterate elderly Chinese: A 3-year cohort study. The Journal of Nutrition, Health & Aging 16 (6):549–52. doi: 10.1007/s12603-012-0023-2.
  • Chen, J., P. Scheltens, C. Groot, and R. Ossenkoppele. 2020. Associations between caffeine consumption, cognitive decline, and dementia: A systematic review. Journal of Alzheimer’s Disease: JAD 78 (4):1519–46.
  • Chuang, S. Y., Y. L. Lo, S. Y. Wu, P. N. Wang, and W. H. Pan. 2019. Dietary patterns and foods associated with cognitive function in Taiwanese older adults: The cross-sectional and longitudinal studies. Journal of the American Medical Directors Association 20 (5):544–50.e4. doi: 10.1016/j.jamda.2018.10.017.
  • Cornelis, M. C., S. Weintraub, and M. C. Morris. 2020. Caffeinated coffee and tea consumption, genetic variation and cognitive function in the UK biobank. The Journal of Nutrition 150 (8):2164–74. doi: 10.1093/jn/nxaa147.
  • Crupi, R., D. Impellizzeri, and S. Cuzzocrea. 2019. Role of metabotropic glutamate receptors in neurological disorders. Frontiers in Molecular Neuroscience 12:20. doi: 10.3389/fnmol.2019.00020.
  • Dai, Q., A. R. Borenstein, Y. Wu, J. C. Jackson, and E. B. Larson. 2006. Fruit and vegetable juices and Alzheimer’s disease: The Kame Project. The American Journal of Medicine 119 (9):751–9. doi: 10.1016/j.amjmed.2006.03.045.
  • Dietz, C., M. Dekker, and B. Piqueras-Fiszman. 2017. An intervention study on the effect of matcha tea, in drink and snack bar formats, on mood and cognitive performance. Food Research International (Ottawa, ON) 99 (Pt 1):72–83. doi: 10.1016/j.foodres.2017.05.002.
  • Dominguez, L. J., N. Veronese, L. Vernuccio, G. Catanese, F. Inzerillo, G. Salemi, and M. Barbagallo. 2021. Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia. Nutrients 13 (11):4080. doi: 10.3390/nu13114080.
  • Eskelinen, M. H., T. Ngandu, J. Tuomilehto, H. Soininen, and M. Kivipelto. 2009. Midlife coffee and tea drinking and the risk of late-life dementia: A population-based CAIDE study. Journal of Alzheimer’s Disease: JAD 16 (1):85–91. doi: 10.3233/JAD-2009-0920.
  • Ettcheto, M., A. Cano, P. R. Manzine, O. Busquets, E. Verdaguer, R. D. Castro-Torres, M. L. García, C. Beas-Zarate, J. Olloquequi, C. Auladell, et al. 2020. Epigallocatechin-3-Gallate (EGCG) improves cognitive deficits aggravated by an obesogenic diet through modulation of unfolded protein response in APPswe/PS1dE9 mice. Molecular Neurobiology 57 (4):1814–27. doi: 10.1007/s12035-019-01849-6.
  • Farkhondeh, T., A. M. Pourbagher-Shahri, M. Ashrafizadeh, S. L. Folgado, A. Rajabpour-Sanati, M. R. Khazdair, and S. Samarghandian. 2020. Green tea catechins inhibit microglial activation which prevents the development of neurological disorders. Neural Regeneration Research 15 (10):1792–8. doi: 10.4103/1673-5374.280300.
  • Feng, L., M. S. Chong, W. S. Lim, Q. Gao, M. Nyunt, T. S. Lee, S. Collinson, T. Tsoi, E. H. Kua, and T. P. Ng. 2016. Tea consumption reduces the incidence of neurocognitive disorders: Findings from the Singapore longitudinal aging study. The Journal of Nutrition, Health & Aging 20 (10):1002–9. doi: 10.1007/s12603-016-0687-0.
  • Feng, L., L. Langsetmo, K. Yaffe, Y. Sun, H. A. Fink, J. M. Shikany, P. Leung, N. E. Lane, J. A. Cauley, and Osteoporotic Fractures in Men (MrOS) Study Group. 2018. No effects of black tea on cognitive decline among older US men: A prospective cohort study. Journal of Alzheimer’s Disease 65 (1):99–105. doi: 10.3233/JAD-180103.
  • Feter, N., S. C. Dumith, E. C. Smith, L. L. da Cunha, J. Cassuriaga, J. S. Leite, R. Alt, J. S. Coombes, and A. J. Rombaldi. 2021. Physical activity attenuates the risk for dementia associated with aging in older adults with mild cognitive impairment. Findings from a population-based cohort study. Journal of Psychiatric Research 141:1–8. doi: 10.1016/j.jpsychires.2021.06.034.
  • Fischer, K., D. Melo van Lent, S. Wolfsgruber, L. Weinhold, L. Kleineidam, H. Bickel, M. Scherer, M. Eisele, H. van den Bussche, B. Wiese, et al. 2018. Prospective associations between single foods, Alzheimer’s dementia and memory decline in the elderly. Nutrients 10 (7):852. doi: 10.3390/nu10070852.
  • GBD 2019 Dementia Forecasting Collaborators. 2022. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. The Lancet Public Health 7 (2),e105–e125.
  • Gu, Y. J., C. H. He, S. Li, S. Y. Zhang, S. Y. Duan, H. P. Sun, Y. P. Shen, Y. Xu, J. Y. Yin, and C. W. Pan. 2018. Tea consumption is associated with cognitive impairment in older Chinese adults. Aging & Mental Health 22 (9):1237–43. doi: 10.1080/13607863.2017.1339779.
  • Haque, A. M., M. Hashimoto, M. Katakura, Y. Hara, and O. Shido. 2008. Green tea catechins prevent cognitive deficits caused by Aβ1–40 in rats. The Journal of Nutritional Biochemistry 19 (9):619–26. doi: 10.1016/j.jnutbio.2007.08.008.
  • Hetz, C., and B. Mollereau. 2014. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nature Reviews. Neuroscience 15 (4):233–49. doi: 10.1038/nrn3689.
  • Hickman, S., S. Izzy, P. Sen, L. Morsett, and J. El Khoury. 2018. Microglia in neurodegeneration. Nature Neuroscience 21 (10):1359–69. doi: 10.1038/s41593-018-0242-x.
  • Hidese, S., S. Ogawa, M. Ota, I. Ishida, Z. Yasukawa, M. Ozeki, and H. Kunugi. 2019. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial. Nutrients 11 (10):2362. doi: 10.3390/nu11102362.
  • Hooper, L., P. A. Kroon, E. B. Rimm, J. S. Cohn, I. Harvey, K. A. Le Cornu, J. J. Ryder, W. L. Hall, and A. Cassidy. 2008. Flavonoids, flavonoid-rich foods, and cardiovascular risk: A meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition 88 (1):38–50. doi: 10.1093/ajcn/88.1.38.
  • Hu, H. Y., B. S. Wu, Y. N. Ou, Y. H. Ma, Y. Y. Huang, W. Cheng, L. Tan, and J. T. Yu. 2022. Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants. Translational Psychiatry 12 (1):1–9. doi: 10.1038/s41398-022-01923-z.
  • Huang, C. Q., B. R. Dong, Y. L. Zhang, H. M. Wu, and Q. X. Liu. 2009. Association of cognitive impairment with smoking, alcohol consumption, tea consumption, and exercise among Chinese nonagenarians/centenarians. Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology 22 (3):190–6. doi: 10.1097/WNN.0b013e3181b2790b.
  • Huang, Y., and L. Mucke. 2012. Alzheimer mechanisms and therapeutic strategies. Cell 148 (6):1204–22. doi: 10.1016/j.cell.2012.02.040.
  • Ide, K., H. Yamada, N. Takuma, Y. Kawasaki, S. Harada, J. Nakase, Y. Ukawa, and Y. M. Sagesaka. 2015. Effects of green tea consumption on cognitive dysfunction in an elderly population: A randomized placebo-controlled study. Nutrition Journal 15 (1):9. doi: 10.1186/s12937-016-0168-7.
  • Ide, K., H. Yamada, N. Takuma, M. Park, N. Wakamiya, J. Nakase, Y. Ukawa, and Y. M. Sagesaka. 2014. Green tea consumption affects cognitive dysfunction in the elderly: A pilot study. Nutrients 6 (10):4032–42. doi: 10.3390/nu6104032.
  • Kakuda, T., E. Hinoi, A. Abe, A. Nozawa, M. Ogura, and Y. Yoneda. 2008. Theanine, an ingredient of green tea, inhibits [3H] glutamine transport in neurons and astroglia in rat brain. Journal of Neuroscience Research 86 (8):1846–56. doi: 10.1002/jnr.21637.
  • Kim, Y. S., S. M. Kwak, and S. K. Myung. 2015. Caffeine intake from coffee or tea and cognitive disorders: A meta-analysis of ­observational studies. Neuroepidemiology 44 (1):51–63. doi: 10.1159/000371710.
  • Kim, T. I., Y. K. Lee, S. G. Park, I. S. Choi, J. O. Ban, H. K. Park, S.-Y. Nam, Y. W. Yun, S. B. Han, K. W. Oh, et al. 2009. l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways. Free Radical Biology & Medicine 47 (11):1601–10. doi: 10.1016/j.freeradbiomed.2009.09.008.
  • Kim, C. Y., C. Lee, G. H. Park, and J. H. Jang. 2009. Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity. Archives of Pharmacal Research 32 (6):869–81. doi: 10.1007/s12272-009-1609-z.
  • Kitamura, K., Y. Watanabe, K. Nakamura, K. Sanpei, M. Wakasugi, A. Yokoseki, O. Onodera, T. Ikeuchi, R. Kuwano, T. Momotsu, et al. 2016. Modifiable factors associated with cognitive impairment in 1,143 Japanese outpatients: The Project in Sado for Total Health (PROST). Dementia and Geriatric Cognitive Disorders Extra 6 (2):341–9. doi: 10.1159/000447963.
  • Kivipelto, M., F. Mangialasche, and T. Ngandu. 2018. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nature Reviews. Neurology 14 (11):653–66. doi: 10.1038/s41582-018-0070-3.
  • Kuriyama, S., A. Hozawa, K. Ohmori, T. Shimazu, T. Matsui, S. Ebihara, S. Awata, R. Nagatomi, H. Arai, and I. Tsuji. 2006. Green tea consumption and cognitive function: A cross-sectional study from the Tsurugaya Project. The American Journal of Clinical Nutrition 83 (2):355–61. doi: 10.1093/ajcn/83.2.355.
  • Lee, J. W., Y. K. Lee, J. O. Ban, T. Y. Ha, Y. P. Yun, S. B. Han, K. W. Oh, and J. T. Hong. 2009. Green tea (-)-epigallocatechin-3-gallate inhibits β-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-κ B pathways in mice. The Journal of Nutrition 139 (10):1987–93. doi: 10.3945/jn.109.109785.
  • Lee, C., Y. Sun, H. Lee, T. Chen, P. Wang, K. Lin, L. Tang, C. Lin, and M. Chiu. 2017. Modest overweight and healthy dietary habits reduce risk of dementia: A nationwide survey in Taiwan. The Journal of Prevention of Alzheimer’s Disease 4 (1):37–43.
  • Li, C., S. Chai, Y. Ju, L. Hou, H. Zhao, W. Ma, T. Li, J. Sheng, and W. Shi. 2017. Pu-erh tea protects the nervous system by inhibiting the expression of metabotropic glutamate receptor 5. Molecular Neurobiology 54 (7):5286–99.
  • Limongi, F., P. Siviero, A. Bozanic, M. Noale, N. Veronese, and S. Maggi. 2020. The effect of adherence to the Mediterranean diet on late-life cognitive disorders: A systematic review. Journal of the American Medical Directors Association 21 (10):1402–9. doi: 10.1016/j.jamda.2020.08.020.
  • Lindsay, J., D. Laurin, R. Verreault, R. Hébert, B. Helliwell, G. B. Hill, and I. McDowell. 2002. Risk factors for Alzheimer’s disease: A prospective analysis from the Canadian Study of Health and Aging. American Journal of Epidemiology 156 (5):445–53. doi: 10.1093/aje/kwf074.
  • Liu, Z., M. E. Bruins, L. Ni, and J. P. Vincken. 2018. Green and black tea phenolics: Bioavailability, transformation by colonic microbiota, and modulation of colonic microbiota. Journal of Agricultural and Food Chemistry 66 (32):8469–77. doi: 10.1021/acs.jafc.8b02233.
  • Liu, X., X. Du, G. Han, and W. Gao. 2017. Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies. Oncotarget 8 (26):43306–21. doi: 10.18632/oncotarget.17429.
  • Li, W., L. Yue, and S. Xiao. 2022. Prospective associations of tea consumption with risk of cognitive decline in the elderly: A 1-year follow-up study in China. Frontiers in Nutrition 9:752833. doi: 10.3389/fnut.2022.752833.
  • Ma, Q. P., C. Huang, Q. Y. Cui, D. J. Yang, K. Sun, X. Chen, and X. H. Li. 2016. Meta-analysis of the association between tea intake and the risk of cognitive disorders. PloS One 11 (11):e0165861.
  • Mathiyazahan, D. B., A. J. Thenmozhi, and T. Manivasagam. 2015. Protective effect of black tea extract against aluminium chloride-induced Alzheimer’s disease in rats: A behavioural, ­biochemical and molecular approach. Journal of Functional Foods 16:423–35. doi: 10.1016/j.jff.2015.05.001.
  • Ng, T. P., L. Feng, M. Niti, E. H. Kua, and K. B. Yap. 2008. Tea consumption and cognitive impairment and decline in older Chinese adults. The American Journal of Clinical Nutrition 88 (1):224–31. doi: 10.1093/ajcn/88.1.224.
  • Noguchi-Shinohara, M., S. Yuki, C. Dohmoto, Y. Ikeda, M. Samuraki, K. Iwasa, M. Yokogawa, K. Asai, K. Komai, H. Nakamura, et al. 2014. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PloS One 9 (5):e96013. doi: 10.1371/journal.pone.0096013.
  • Nurk, E., H. Refsum, C. A. Drevon, G. S. Tell, H. A. Nygaard, K. Engedal, and A. D. Smith. 2009. Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. The Journal of Nutrition 139 (1):120–7. doi: 10.3945/jn.108.095182.
  • Okaty, B. W., K. G. Commons, and S. M. Dymecki. 2019. Embracing diversity in the 5-HT neuronal system. Nature Reviews Neuroscience 20 (7):397–424. doi: 10.1038/s41583-019-0151-3.
  • Panza, F., V. Solfrizzi, M. Barulli, C. Bonfiglio, V. Guerra, A. Osella, D. Seripa, C. Sabbà, A. Pilotto, and G. Logroscino. 2015. Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review. The Journal of Nutrition, Health & Aging 19 (3):313–28. doi: 10.1007/s12603-014-0563-8.
  • Park, S.-K., I.-C. Jung, W. K. Lee, Y. S. Lee, H. K. Park, H. J. Go, K. Kim, N. K. Lim, J. T. Hong, S. Y. Ly, et al. 2011. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: A double-blind placebo-controlled study. Journal of Medicinal Food 14 (4):334–43. doi: 10.1089/jmf.2009.1374.
  • Perron, N. R., H. C. Wang, S. N. DeGuire, M. Jenkins, M. Lawson, and J. L. Brumaghim. 2010. Kinetics of iron oxidation upon polyphenol binding. Dalton Transactions (Cambridge, England: 2003) 39 (41):9982–7. doi: 10.1039/c0dt00752h.
  • Pervin, M., K. Unno, A. Takagaki, M. Isemura, and Y. Nakamura. 2019. Function of green tea catechins in the brain: Epigallocatechin gallate and its metabolites. International Journal of Molecular Sciences 20 (15):3630. doi: 10.3390/ijms20153630.
  • Power, M. C., E. E. Bennett, R. W. Turner, N. M. Dowling, A. Ciarleglio, M. M. Glymour, and K. Z. Gianattasio. 2021. Trends in relative incidence and prevalence of dementia across non-Hispanic Black and White individuals in the United States, 2000-2016. JAMA Neurology 78 (3):275–84. doi: 10.1001/jamaneurol.2020.4471.
  • Prinz, M., T. Masuda, M. A. Wheeler, and F. J. Quintana. 2021. Microglia and central nervous system–associated macrophages—from origin to disease modulation. Annual Review of Immunology 39:251–77. doi: 10.1146/annurev-immunol-093019-110159.
  • Qi, C., P. Wang, T. Fu, M. Lu, Y. Cai, X. Chen, and L. Cheng. 2021. A comprehensive review for gut microbes: Technologies, interventions, metabolites and diseases. Briefings in Functional Genomics 20 (1):42–60.
  • Quan, W., Y. Jiao, C. Xue, Y. Li, Z. Wang, M. Zeng, F. Qin, Z. He, and J. Chen. 2022. Processed potatoes intake and risk of type 2 diabetes: A systematic review and meta-analysis of nine prospective cohort studies. Critical Reviews in Food Science and Nutrition 62 (5):1417–25.
  • Quan, W., M. Zeng, Y. Jiao, Y. Li, C. Xue, G. Liu, Z. Wang, F. Qin, Z. He, and J. Chen. 2021. Western dietary patterns, foods, and risk of gestational diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies. Advances in Nutrition (Bethesda, MD) 12 (4):1353–64. doi: 10.1093/advances/nmaa184.
  • Ran, L., W. Liu, Y. Fang, S. Xu, J. Li, X. Luo, D. Pan, M. Wang, and W. Wang. 2021. Alcohol, coffee and tea intake and the risk of cognitive deficits: A dose–response meta-analysis. Epidemiology and Psychiatric Sciences 30 (e18):1–18.
  • Récamier-Carballo, S., E. Estrada-Camarena, and C. López-Rubalcava. 2017. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: Differential effects after a stress challenge. Behavioural Pharmacology 28 (7):545–57. doi: 10.1097/FBP.0000000000000324.
  • Ren, J. L., Q. X. Yu, W. C. Liang, P. Y. Leung, T. K. Ng, W. K. Chu, C. P. Pang, and S. O. Chan. 2018. Green tea extract attenuates LPS-induced retinal inflammation in rats. Scientific Reports 8:1–10.
  • Rezai-Zadeh, K., G. W. Arendash, H. Hou, F. Fernandez, M. Jensen, M. Runfeldt, R. D. Shytle, and J. Tan. 2008. Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Research 1214:177–87. doi: 10.1016/j.brainres.2008.02.107.
  • Ritchie, K. 2022. Mild cognitive impairment: An epidemiological perspective. Dialogues in Clinical Neuroscience 6 (4):401–408.
  • Ritchie, K., and J. Touchon. 2000. Mild cognitive impairment: Conceptual basis and current nosological status. The Lancet 355 (9199):225–8. doi: 10.1016/S0140-6736(99)06155-3.
  • Rrapo, E., Y. Zhu, J. Tian, H. Hou, A. Smith, F. Fernandez, J. Tan, and B. Giunta. 2009. Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. American Journal of Translational Research 1 (1):72–9.
  • Sakurai, K., C. Shen, Y. Ezaki, N. Inamura, Y. Fukushima, N. Masuoka, and T. Hisatsune. 2020. Effects of matcha green tea powder on cognitive functions of community-dwelling elderly individuals. Nutrients 12 (12):3639. doi: 10.3390/nu12123639.
  • Santamaría-del Ángel, D., N. A. Labra-Ruíz, M. E. García-Cruz, D. Calderón-Guzmán, A. Valenzuela-Peraza, and H. Juárez-Olguín. 2016. Comparative effects of catechin, epicatechin and N-Ω-nitroarginine on quinolinic acid-induced oxidative stress in rat striatum slices. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 78:210–5. doi: 10.1016/j.biopha.2016.01.016.
  • Scarmeas, N., C. A. Anastasiou, and M. Yannakoulia. 2018. Nutrition and prevention of cognitive impairment. The Lancet. Neurology 17 (11):1006–15. doi: 10.1016/S1474-4422(18)30338-7.
  • Schaefer, S. M., A. Kaiser, I. Behrendt, G. Eichner, and M. Fasshauer. 2022. Association of alcohol types, coffee, and tea intake with risk of dementia: Prospective cohort study of UK biobank participants. Brain Sciences 12 (3):360. doi: 10.3390/brainsci12030360.
  • Schousboe, A. 2019. Metabolic signaling in the brain and the role of astrocytes in control of glutamate and GABA neurotransmission. Neuroscience Letters 689:11–3. doi: 10.1016/j.neulet.2018.01.038.
  • Seong, K.-J., H.-G. Lee, M. S. Kook, H.-M. Ko, J.-Y. Jung, and W.-J. Kim. 2016. Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology 20 (1):41–51. doi: 10.4196/kjpp.2016.20.1.41.
  • Sharangi, A. 2009. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.)–A review. Food Research International 42 (5–6):529–35. doi: 10.1016/j.foodres.2009.01.007.
  • Shen, W., Y. Xiao, X. Ying, S. Li, Y. Zhai, X. Shang, F. Li, X. Wang, F. He, and J. Lin. 2015. Tea consumption and cognitive impairment: A cross-sectional study among Chinese elderly. PloS One 10 (9):e0137781. doi: 10.1371/journal.pone.0137781.
  • Shirai, Y., K. Kuriki, R. Otsuka, Y. Kato, Y. Nishita, C. Tange, M. Tomida, T. Imai, F. Ando, and H. Shimokata. 2019. Association between green tea intake and risk of cognitive decline, considering glycated hemoglobin level, in older Japanese adults: The NILS-LSA study. Nagoya Journal of Medical Science 81 (4):655–66. doi: 10.18999/nagjms.81.4.655.
  • Shirai, Y., K. Kuriki, R. Otsuka, Y. Kato, Y. Nishita, C. Tange, M. Tomida, T. Imai, F. Ando, and H. Shimokata. 2020. Green tea and coffee intake and risk of cognitive decline in older adults: The National Institute for Longevity Sciences, Longitudinal Study of Aging. Public Health Nutrition 23 (6):1049–57. doi: 10.1017/S1368980019002659.
  • Stroup, D. F., J. A. Berlin, S. C. Morton, I. Olkin, G. D. Williamson, D. Rennie, D. Moher, B. J. Becker, T. A. Sipe, and S. B. Thacker. 2000. Meta-analysis of observational studies in epidemiology: A proposal for reporting. JAMA 283 (15):2008–12. doi: 10.1001/jama.283.15.2008.
  • Toews, I., S. Lohner, D. K. de Gaudry, H. Sommer, and J. J. Meerpohl. 2019. Association between intake of non-sugar sweeteners and health outcomes: Systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ:k4718. doi: 10.1136/bmj.k4718.
  • Tomata, Y., M. Kakizaki, N. Nakaya, T. Tsuboya, T. Sone, S. Kuriyama, A. Hozawa, and I. Tsuji. 2012. Green tea consumption and the risk of incident functional disability in elderly Japanese: The Ohsaki Cohort 2006 Study. The American Journal of Clinical Nutrition 95 (3):732–9. doi: 10.3945/ajcn.111.023200.
  • Tomata, Y., K. Sugiyama, Y. Kaiho, K. Honkura, T. Watanabe, S. Zhang, Y. Sugawara, and I. Tsuji. 2016. Green tea consumption and the risk of incident dementia in elderly Japanese: The Ohsaki Cohort 2006 Study. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry 24 (10):881–9. doi: 10.1016/j.jagp.2016.07.009.
  • Trichopoulou, A., A. Kyrozis, M. Rossi, M. Katsoulis, D. Trichopoulos, C. La Vecchia, and P. Lagiou. 2015. Mediterranean diet and cognitive decline over time in an elderly Mediterranean population. European Journal of Nutrition 54 (8):1311–21. doi: 10.1007/s00394-014-0811-z.
  • Tyas, S. L., J. Manfreda, L. A. Strain, and P. R. Montgomery. 2001. Risk factors for Alzheimer’s disease: A population-based, longitudinal study in Manitoba, Canada. International Journal of Epidemiology 30 (3):590–7. doi: 10.1093/ije/30.3.590.
  • Vercambre, M. N., M. C. Boutron Ruault, K. Ritchie, F. Clavel Chapelon, and C. Berr. 2009. Long-term association of food and nutrient intakes with cognitive and functional decline: A 13-year follow-up study of elderly French women. The British Journal of Nutrition 102 (3):419–27. doi: 10.1017/S0007114508201959.
  • Wan, J., M. Feng, W. Pan, X. Zheng, X. Xie, B. Hu, C. Teng, Y. Wang, Z. Liu, J. Wu, et al. 2021. Inhibitory effects of six types of tea on aging and high-fat diet-related amyloid formation activities. Antioxidants 10 (10):1513. doi: 10.3390/antiox10101513.
  • Wang, T., S. Xiao, K. Chen, C. Yang, S. Dong, Y. Cheng, X. Li, J. Wang, M. Zhu, F. Yang, et al. 2017. Prevalence, incidence, risk and protective factors of amnestic mild cognitive impairment in the elderly in Shanghai. Current Alzheimer Research 14 (4):460–6.
  • Wells, G. A., B. Shea, D. O’Connell, J. Peterson, V. Welch, M. Losos, and P. Tugwell. 2000. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Oxford.
  • Williams, J., D. Sergi, A. J. McKune, E. N. Georgousopoulou, D. D. Mellor, and N. Naumovski. 2019. The beneficial health effects of green tea amino acid l‐theanine in animal models: Promises and prospects for human trials. Phytotherapy Research: PTR 33 (3):571–83. doi: 10.1002/ptr.6277.
  • Wimo, A., L. Jönsson, J. Bond, M. Prince, B. Winblad, and Alzheimer Disease International. 2013. The worldwide economic impact of dementia 2010. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 9 (1):1–11.e3. doi: 10.1016/j.jalz.2012.11.006.
  • Wu, Z., S. Huang, T. Li, N. Li, D. Han, B. Zhang, Z. Z. Xu, S. Zhang, J. Pang, S. Wang, et al. 2021. Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis. Microbiome 9 (1):1–22. doi: 10.1186/s40168-021-01115-9.
  • Wu, M. S., T. H. Lan, C. M. Chen, H. C. Chiu, and T. Y. Lan. 2011. Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan. BMC Public Health 11 (1):1–8. doi: 10.1186/1471-2458-11-22.
  • Xu, H., Y. Wang, Y. Yuan, X. Zhang, X. Zuo, L. Cui, Y. Liu, W. Chen, N. Su, H. Wang, et al. 2018. Gender differences in the protective effects of green tea against amnestic mild cognitive impairment in the elderly Han population. Neuropsychiatric Disease and Treatment 14:1795–801.
  • Yao, Y. H., R. F. Xu, H. D. Tang, G. X. Jiang, Y. Wang, G. Wang, S. D. Chen, and Q. Cheng. 2010. Cognitive impairment and associated factors among the elderly in the Shanghai suburb: Findings from a low-education population. Neuroepidemiology 34 (4):245–52. doi: 10.1159/000297751.
  • Zecca, L., M. B. Youdim, P. Riederer, J. R. Connor, and R. R. Crichton. 2004. Iron, brain ageing and neurodegenerative disorders. Nature Reviews. Neuroscience 5 (11):863–73. doi: 10.1038/nrn1537.
  • Zhang, J., A. Wang, X. Zhang, S. Chen, S. Wu, X. Zhao, and Q. Zhang. 2020. Association between tea consumption and cognitive impairment in middle-aged and older adults. BMC Geriatrics 20 (1):1–9. doi: 10.1186/s12877-020-01848-6.
  • Zhang, Y., H. Yang, S. Li, W.-D. Li, and Y. Wang. 2021. Consumption of coffee and tea and risk of developing stroke, dementia, and poststroke dementia: A cohort study in the UK Biobank. PLoS Medicine 18 (11):e1003830. doi: 10.1371/journal.pmed.1003830.
  • Zhang, Z., Y. Zhang, J. Li, C. Fu, and X. Zhang. 2021. The neuroprotective effect of tea polyphenols on the regulation of intestinal flora. Molecules 26 (12):3692. doi: 10.3390/molecules26123692.
  • Zhong, X., M. Liu, W. Yao, K. Du, M. He, X. Jin, L. Jiao, G. Ma, B. Wei, and M. Wei. 2019. Epigallocatechin‐3‐gallate attenuates microglial inflammation and neurotoxicity by suppressing the activation of canonical and noncanonical inflammasome via TLR4/NF‐κB pathway. Molecular Nutrition & Food Research 63 (21):1801230. doi: 10.1002/mnfr.201801230.
  • Zhu, W. L., H. S. Shi, Y. M. Wei, S. J. Wang, C. Y. Sun, Z. B. Ding, and L. Lu. 2012. Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacological Research 65 (1):74–80. doi: 10.1016/j.phrs.2011.09.007.
  • Zia, A., A. M. Pourbagher-Shahri, T. Farkhondeh, and S. Samarghandian. 2021. Molecular and cellular pathways contributing to brain aging. Behavioral and Brain Functions 17 (1):1–30. doi: 10.1186/s12993-021-00179-9.
  • Zupo, R., C. Griseta, P. Battista, R. Donghia, V. Guerra, F. Castellana, L. Lampignano, I. Bortone, M. Lozupone, and G. Giannelli. 2021. Role of plant-based diet in late-life cognitive decline: Results from the Salus in Apulia Study. Nutritional Neuroscience 25 (6):1300–1309.

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