Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection

References

• Aguilo N, Alvarez-Arguedas S, Uranga S, Marinova D, Monzon M, Badiola J, Martin C. 2016. Pulmonary but not subcutaneous delivery of BCG vaccine confers protection to tuberculosis-susceptible mice by an interleukin 17-dependent mechanism. J Infect Dis. 213:831–839.
   PubMed Web of Science ®Google Scholar
• Amatya N, Garg AV, Gaffen SL. 2017. IL-17 signaling: the Yin and the Yang. Trends Immunol. 38:310–322.
   PubMed Web of Science ®Google Scholar
• Arababadi MK, Bidaki MZ, Kennedy D. 2014. IL-17A in hepatitis B infection: friend or foe? Arch Virol. 159:1883–1888.
   PubMed Web of Science ®Google Scholar
• Archer NK, Adappa ND, Palmer JN, Cohen NA, Harro JM, Lee SK, Miller LS, Shirtliff ME. 2016. Interleukin-17A (IL-17A) and IL-17F are critical for antimicrobial peptide production and clearance of Staphylococcus aureus nasal colonization. Infect Immun. 84:3575–3583.
   PubMed Web of Science ®Google Scholar
• Archer NK, Harro JM, Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun. 81:2070–2075.
   PubMed Web of Science ®Google Scholar
• Arranz-Valsero I, Schulze U, Contreras-Ruiz L, Garcia-Posadas L, Lopez-Garcia A, Paulsen F, Diebold Y. 2013. Involvement of corneal epithelial cells in the Th17 response in an in vitro bacterial inflammation model. Mol Vis. 19:85–99.
   PubMed Web of Science ®Google Scholar
• Babb R, Chen A, Hirst TR, Kara EE, McColl SR, Ogunniyi AD, Paton JC, Alsharifi M. 2016. Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses. Clin Sci. 130:697–710.
   PubMed Web of Science ®Google Scholar
• Baeten D, Baraliakos X, Braun J, Sieper J, Emery P, van der Heijde D, McInnes I, van Laar JM, Landewé R, Wordsworth P, et al. 2013. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet. 382:1705–1713.
   PubMed Web of Science ®Google Scholar
• Bagheri N, Azadegan-Dehkordi F, Shirzad H, Rafieian-Kopaei M, Rahimian G, Razavi A. 2015. The biological functions of IL-17 in different clinical expressions of Helicobacter pylori-infection. Microb Pathog. 81:33–38.
   PubMed Web of Science ®Google Scholar
• Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, et al. 2015. Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus. Proc Natl Acad Sci USA. 112:3680–3685.
   PubMed Web of Science ®Google Scholar
• Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X. 2009. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J Immunol. 183:5886–5895.
   PubMed Web of Science ®Google Scholar
• Barin JG, Talor MV, Schaub JA, Diny NL, Hou X, Hoyer M, Archer NK, Gebremariam ES, Davis MF, Miller LS, et al. 2016. Collaborative interferon-γ and interleukin-17 signaling protects the oral mucosa from Staphylococcus aureus. Am J Pathol. 186:2337–2352.
   PubMed Web of Science ®Google Scholar
• Bayes HK, Ritchie ND, Evans TJ. 2016. Interleukin-17 is required for control of chronic lung infection caused by Pseudomonas aeruginosa. Infect Immun. 84:3507–3516.
   PubMed Web of Science ®Google Scholar
• Bhan U, Ballinger MN, Zeng X, Newstead MJ, Cornicelli MD, Standiford TJ. 2010. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS ONE. 5:e9896.
   PubMed Web of Science ®Google Scholar
• Bie Q, Jin C, Zhang B, Dong H. 2017. IL-17B: a new area of study in the IL-17 family. Mol Immunol. 90:50–56.
   PubMed Web of Science ®Google Scholar
• Binger KJ, Corte-Real BF, Kleinewietfeld M. 2017. Immunometabolic regulation of interleukin-17-producing T helper cells: uncoupling new targets for autoimmunity. Front Immunol. 8:311.
   PubMed Web of Science ®Google Scholar
• Bjorkander S, Hell L, Johansson MA, Forsberg MM, Lasaviciute G, Roos S, Holmlund U, Sverremark-Ekstrom E. 2016. Staphylococcus aureus-derived factors induce IL-10, IFN-gamma and IL-17A-expressing FOXP3 + CD161+ T-helper cells in a partly monocyte-dependent manner. Sci Rep. 6:22083.
   PubMed Web of Science ®Google Scholar
• Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, Goleniewska K, Kolls JK, Peebles RS. Jr. 2016. STAT6 signaling attenuates interleukin-17-producing gammadelta T cells during acute Klebsiella pneumoniae infection. Infect Immun. 84:1548–1555.
   PubMed Web of Science ®Google Scholar
• Bogdan C. 2015. Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol. 36:161–178.
   PubMed Web of Science ®Google Scholar
• Bot A, Rossi M. 2015. In this issue: the multiple facets of IL-17. Int Rev Immunol. 34:293–294.
   PubMed Web of Science ®Google Scholar
• Bystrom J, Al-Adhoubi N, Al-Bogami M, Jawad AS, Mageed RA. 2013. Th17 lymphocytes in respiratory syncytial virus infection. Viruses. 5:777–791.
   PubMed Web of Science ®Google Scholar
• Cantero D, Cooksley C, Bassiouni A, Tran HB, Roscioli E, Wormald PJ, Vreugde S. 2015. Staphylococcus aureus biofilms induce apoptosis and expression of interferon-γ, interleukin-10, and interleukin-17A on human sinonasal explants. Am J Rhinol Allergy. 29:23–28.
   PubMed Web of Science ®Google Scholar
• Carey AJ, Tan CK, Mirza S, Irving-Rodgers H, Webb RI, Lam A, Ulett GC. 2014. Infection and cellular defense dynamics in a novel 17beta-estradiol murine model of chronic human group B streptococcus genital tract colonization reveal a role for hemolysin in persistence and neutrophil accumulation. J Immunol. 192:1718–1731.
   PubMed Web of Science ®Google Scholar
• Carey AJ, Tan CK, Ulett GC. 2012. Infection-induced IL-10 and JAK-STAT: a review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes. JAKSTAT. 1:159–167.
   PubMedGoogle Scholar
• Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon MG, Walker MJ, Watson ME, Ulett GC. 2016. Interleukin-17A contributes to the control of Streptococcus pyogenes colonization and inflammation of the female genital tract. Sci Rep. 6:26836.
   PubMed Web of Science ®Google Scholar
• Caruso R, Fina D, Paoluzi OA, Del Vecchio Blanco G, Stolfi C, Rizzo A, Caprioli F, Sarra M, Andrei F, Fantini MC, et al. 2008. IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa. Eur J Immunol. 38:470–478.
   PubMed Web of Science ®Google Scholar
• Chan LC, Chaili S, Filler SG, Barr K, Wang H, Kupferwasser D, Edwards JE Jr, Xiong YQ, Ibrahim AS, Miller LS, et al. 2015. Nonredundant roles of interleukin-17A (IL-17A) and IL-22 in murine host defense against cutaneous and hematogenous infection due to methicillin-resistant Staphylococcus aureus. Infect Immun. 83:4427–4437.
   PubMed Web of Science ®Google Scholar
• Chan YR, Chen K, Duncan SR, Lathrop KL, Latoche JD, Logar AJ, Pociask DA, Wahlberg BJ, Ray P, Ray A, et al. 2013. Patients with cystic fibrosis have inducible IL-17 + IL-22+ memory cells in lung draining lymph nodes. J Allergy Clin Immunol. 131:1117–1129.
   PubMed Web of Science ®Google Scholar
• Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, et al. 2016. IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae. Cell Host Microbe. 20:596–605.
   PubMed Web of Science ®Google Scholar
• Chen Y, Qian T, Zhang D, Yan H, Hao F. 2015. Clinical efficacy and safety of anti-IL-17 agents for the treatment of patients with psoriasis. Immunotherapy. 7:1023–1037.
   PubMed Web of Science ®Google Scholar
• Cho CG, Gong SH, Kim HB, Song JJ, Park JH, Lim YS, Park SW. 2016. Role of group 3 innate lymphoid cells during experimental otitis media in a rat model. Int J Pediatr Otorhinolaryngol. 88:146–152.
   PubMed Web of Science ®Google Scholar
• Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, et al. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 120:1762–1773.
   PubMed Web of Science ®Google Scholar
• Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol. 170:1958–1963.
   PubMed Web of Science ®Google Scholar
• Coccia M, Harrison OJ, Schiering C, Asquith MJ, Becher B, Powrie F, Maloy KJ. 2012. IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med. 209:1595–1609.
   PubMed Web of Science ®Google Scholar
• Conti HR, Gaffen SL. 2015. IL-17-mediated immunity to the opportunistic fungal pathogen Candida albicans. J Immunol. 195:780–788.
   PubMed Web of Science ®Google Scholar
• Cooney LA, Towery K, Endres J, Fox DA. 2011. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol. 187:4440–4450.
   PubMed Web of Science ®Google Scholar
• Cua DJ, Tato CM. 2010. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 10:479–489.
   PubMed Web of Science ®Google Scholar
• Dando SJ, Ipe DS, Batzloff M, Sullivan MJ, Crossman DK, Crowley M, Strong E, Kyan S, Leclercq SY, Ekberg JA, et al. 2016. Burkholderia pseudomallei capsule exacerbates respiratory melioidosis but does not afford protection against antimicrobial signaling or bacterial killing in human olfactory ensheathing cells. Infect Immun. 84:1941–1956.
   PubMed Web of Science ®Google Scholar
• Dando SJ, Mackay-Sim A, Norton R, Currie BJ, St John JA, Ekberg JA, Batzloff M, Ulett GC, Beacham IR. 2014. Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion. Clin Microbiol Rev. 27:691–726.
   PubMed Web of Science ®Google Scholar
• De Luca A, Pariano M, Cellini B, Costantini C, Villella VR, Jose SS, Palmieri M, Borghi M, Galosi C, Paolicelli G, et al. 2017. The IL-17F/IL-17RC axis promotes respiratory allergy in the proximal airways. Cell Rep. 20:1667–1680.
   PubMed Web of Science ®Google Scholar
• Deenick EK, Tangye SG. 2007. Autoimmunity: IL-21: a new player in Th17-cell differentiation. Immunol Cell Biol. 85:503–505.
   PubMed Web of Science ®Google Scholar
• Dileepan T, Linehan JL, Moon JJ, Pepper M, Jenkins MK, Cleary PP. 2011. Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog. 7:e1002252.
   PubMed Web of Science ®Google Scholar
• Dileepan T, Smith ED, Knowland D, Hsu M, Platt M, Bittner-Eddy P, Cohen B, Southern P, Latimer E, Harley E, et al. 2016. Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. J Clin Invest. 126:303–317.
   PubMed Web of Science ®Google Scholar
• Dixon BR, Radin JN, Piazuelo MB, Contreras DC, Algood HM. 2016. IL-17a and IL-22 induce expression of antimicrobials in gastrointestinal epithelial cells and may contribute to epithelial cell defense against Helicobacter pylori. PLoS One. 11:e0148514.
   PubMed Web of Science ®Google Scholar
• Dong C. 2008. IL-23/IL-17 biology and therapeutic considerations. J Immunotoxicol. 5:43–46.
   PubMed Web of Science ®Google Scholar
• Du J, Han J, Li X, Zhang Y, Li H, Yang S. 2015. StIL-17 gene polymorphisms in the development of pulmonary tuberculosis. Int J Clin Exp Pathol. 8:3225–3229.
   PubMed Web of Science ®Google Scholar
• Duell BL, Carey AJ, Tan CK, Cui X, Webb RI, Totsika M, Schembri MA, Derrington P, Irving-Rodgers H, Brooks AJ, et al. 2012a. Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection. J Immunol. 188:781–792.
   PubMed Web of Science ®Google Scholar
• Duell BL, Tan CK, Carey AJ, Wu F, Cripps AW, Ulett GC. 2012b. Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis. FEMS Immunol Med Microbiol. 64:295–313.
   PubMedGoogle Scholar
• Espinoza JL, Takami A, Nakata K, Onizuka M, Kawase T, Akiyama H, Miyamura K, Morishima Y, Fukuda T, Kodera Y, et al. 2011. A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. PLoS One. 6:e26229.
   PubMed Web of Science ®Google Scholar
• Feinen B, Jerse AE, Gaffen SL, Russell MW. 2010. Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection. Mucosal Immunol. 3:312–321.
   PubMed Web of Science ®Google Scholar
• Fleige H, Ravens S, Moschovakis GL, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R. 2014. IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 211:643–651.
   PubMed Web of Science ®Google Scholar
• Freches D, Korf H, Denis O, Havaux X, Huygen K, Romano M. 2013. Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection. Immunology. 140:220–231.
   PubMed Web of Science ®Google Scholar
• Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B. 2009. IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol. 182:7846–7854.
   PubMedGoogle Scholar
• Frodermann V, Chau TA, Sayedyahossein S, Toth JM, Heinrichs DE, Madrenas J. 2011. A modulatory interleukin-10 response to staphylococcal peptidoglycan prevents Th1/Th17 adaptive immunity to Staphylococcus aureus. J Infect Dis. 204:253–262.
   PubMed Web of Science ®Google Scholar
• Gaffen SL. 2009. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9:556–567.
   PubMed Web of Science ®Google Scholar
• Gaffen SL, Jain R, Garg AV, Cua DJ. 2014. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol. 14:585–600.
   PubMed Web of Science ®Google Scholar
• Gallegos AM, van Heijst JW, Samstein M, Su X, Pamer EG, Glickman MS. 2011. A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo. PLoS Pathog. 7:e1002052.
   PubMed Web of Science ®Google Scholar
• Gil JH, Seo JW, Cho MS, Ahn JH, Sung HY. 2014. Role of Treg and TH17 cells of the gastric mucosa in children with Helicobacter pylori gastritis. J Pediatr Gastroenterol Nutr. 58:245–251.
   PubMed Web of Science ®Google Scholar
• Gladiator A, Wangler N, Trautwein-Weidner K, LeibundGut-Landmann S. 2013. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J Immunol. 190:521–525.
   PubMed Web of Science ®Google Scholar
• Gopal R, Monin L, Slight S, Uche U, Blanchard E, Fallert Junecko BA, Ramos-Payan R, Stallings CL, Reinhart TA, Kolls JK, et al. 2014. Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection. PLoS Pathog. 10:e1004099
   PubMed Web of Science ®Google Scholar
• Gordon KB, Colombel JF, Hardin DS. 2016. Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. N Engl J Med. 375:345–356.
   PubMed Web of Science ®Google Scholar
• Gu C, Wu L, Li X. 2013. IL-17 family: cytokines, receptors and signaling. Cytokine. 64:477–485.
   PubMed Web of Science ®Google Scholar
• Guo S, Wu LX, Jones CX, Chen L, Hao CL, He L, Zhang JH. 2016. Allergic airway inflammation disrupts interleukin-17 mediated host defense against Streptococcus pneumoniae infection. Int Immunopharmacol. 31:32–38.
   PubMed Web of Science ®Google Scholar
• Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, et al. 2008. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J Immunol. 181:3456–3463.
   PubMed Web of Science ®Google Scholar
• Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, et al. 2005. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med. 202:761–769.
   PubMed Web of Science ®Google Scholar
• Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 6:1123–1132.
   PubMed Web of Science ®Google Scholar
• Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S. 2011. Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr Opin HIV AIDS. 6:221–227.
   PubMed Web of Science ®Google Scholar
• Hsu D, Taylor P, Fletcher D, van Heeckeren R, Eastman J, van Heeckeren A, Davis P, Chmiel JF, Pearlman E, Bonfield TL. 2016. Interleukin-17 pathophysiology and therapeutic intervention in cystic fibrosis lung infection and inflammation. Infect Immun. 84:2410–2421.
   PubMed Web of Science ®Google Scholar
• Hu F, Ding G, Zhang Z, Gatto LA, Hawgood S, Poulain FR, Cooney RN, Wang G. 2016. Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli. Innate Immun. 22:9–20.
   PubMed Web of Science ®Google Scholar
• Huppler AR, Bishu S, Gaffen SL. 2012. Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. Arthritis Res Ther. 14:217.
   PubMed Web of Science ®Google Scholar
• Ingersoll MA, Kline KA, Nielsen HV, Hultgren SJ. 2008. G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cell Microbiol. 10:2568–2578.
   PubMed Web of Science ®Google Scholar
• Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, et al. 2015. CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nat Commun. 6:8644.
   PubMed Web of Science ®Google Scholar
• Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA. 2005. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun. 73:617–621.
   PubMed Web of Science ®Google Scholar
• Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, et al. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 8:369–377.
   PubMed Web of Science ®Google Scholar
• Khader SA, Cooper AM. 2008. IL-23 and IL-17 in tuberculosis. Cytokine. 41:79–83.
   PubMed Web of Science ®Google Scholar
• Khader SA, Guglani L, Rangel-Moreno J, Gopal R, Junecko BA, Fountain JJ, Martino C, Pearl JE, Tighe M, Lin YY, et al. 2011. IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. J Immunol. 187:5402–5407.
   PubMed Web of Science ®Google Scholar
• Kimizuka Y, Kimura S, Saga T, Ishii M, Hasegawa N, Betsuyaku T, Iwakura Y, Tateda K, Yamaguchi K. 2012. Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model. Infect Immun. 80:1121–1127.
   PubMed Web of Science ®Google Scholar
• Kolata JB, Kuhbandner I, Link C, Normann N, Vu CH, Steil L, Weidenmaier C, Broker BM. 2015. The fall of a dogma? Unexpected high T-cell memory response to Staphylococcus aureus in humans. J Infect Dis. 212:830–838.
   PubMed Web of Science ®Google Scholar
• Kolls JK, McCray PB Jr, Chan YR. 2008. Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol. 8:829–835.
   PubMed Web of Science ®Google Scholar
• Krishna S, Miller LS. 2012. Innate and adaptive immune responses against Staphylococcus aureus skin infections. Semin Immunopathol. 34:261–280.
   PubMed Web of Science ®Google Scholar
• Krstic J, Obradovic H, Kukolj T, Mojsilovic S, Okic-Dordevic I, Bugarski D, Santibanez JF. 2015. An overview of interleukin-17A and interleukin-17 receptor A structure, interaction and signaling. Protein Pept Lett. 22:570–578.
   PubMed Web of Science ®Google Scholar
• Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, et al. 2007. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol. 179:5462–5473.
   PubMed Web of Science ®Google Scholar
• Kuwabara T, Ishikawa F, Kondo M, Kakiuchi T. 2017. The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators Inflamm. 2017:3908061.
   PubMed Web of Science ®Google Scholar
• Kwok SK, Lee J, Yu D, Kang KY, Cho ML, Kim HR, Ju JH, Lee SH, Park SH, Kim HY. 2015. A pathogenetic role for IL-21 in primary Sjögren syndrome. Nat Rev Rheumatol. 11:368–374.
   PubMed Web of Science ®Google Scholar
• Langley RG, Elewski BE, Lebwohl M, Reich K, Griffiths CE, Papp K, Puig L, Nakagawa H, Spelman L, Sigurgeirsson B, et al. 2014. Secukinumab in plaque psoriasis-results of two phase 3 trials. N Engl J Med. 371:326–338.
   PubMed Web of Science ®Google Scholar
• Larussa T, Leone I, Suraci E, Nazionale I, Procopio T, Conforti F, Abenavoli L, Hribal ML, Imeneo M, Luzza F. 2015. Enhanced expression of indoleamine 2,3-dioxygenase in Helicobacter pylori-infected human gastric mucosa modulates Th1/Th2 pathway and interleukin 17 production. Helicobacter. 20:41–48.
   PubMed Web of Science ®Google Scholar
• Lee YH, Bae SC. 2017. Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis. Postgrad Med J. 93: 465–471.
   Google Scholar
• Leonardi C, Matheson R, Zachariae C, Cameron G, Li L, Edson-Heredia E, Braun D, Banerjee S. 2012. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 366:1190–1199.
   PubMed Web of Science ®Google Scholar
• Levy R, Okada S, Beziat V, Moriya K, Liu C, Chai LY, Migaud M, Hauck F, Al Ali A, Cyrus C, et al. 2016. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc Natl Acad Sci USA. 113:E8277–E8285.
   PubMed Web of Science ®Google Scholar
• Li C, McClellan SA, Barrett R, Hazlett LD. 2014. Interleukin 17 regulates Mer tyrosine kinase-positive cells in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 55:6886–6900.
   PubMed Web of Science ®Google Scholar
• Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD. 2010. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest. 120:331–342.
   PubMed Web of Science ®Google Scholar
• Lin Y, et al. 2009. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity. 31:799–810.
   PubMed Web of Science ®Google Scholar
• Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK. 2015. Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b + dendritic cells. Proc Natl Acad Sci USA. 112:12782–12787.
   PubMed Web of Science ®Google Scholar
• Liu J, Qu H, Li Q, Ye L, Ma G, Wan H. 2013. The responses of γδ T-cells against acute Pseudomonas aeruginosa pulmonary infection in mice via interleukin-17. Pathog Dis. 68:44–51.
   PubMed Web of Science ®Google Scholar
• Liu WX, Li ZJ, Niu XL, Yao Z, Deng WM. 2015. The role of T helper 17 cells and other IL-17-producing cells in bone resorption and remodeling. Int Rev Immunol. 34:332–347.
   PubMed Web of Science ®Google Scholar
• Lockhart E, Green AM, Flynn JL. 2006. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 177:4662–4669.
   PubMed Web of Science ®Google Scholar
• Lore NI, Cigana C, Riva C, De Fino I, Nonis A, Spagnuolo L, Sipione B, Cariani L, Girelli D, Rossi G, et al. 2016. IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa. Sci Rep. 6:2593.
   Google Scholar
• Lu S, Li H, Gao R, Gao X, Xu F, Wang Q, Lu G, Xia D, Zhou J. 2015. IL-17A, but not IL-17F, is indispensable for airway vascular remodeling induced by exaggerated Th17 cell responses in prolonged ovalbumin-challenged mice. J Immunol. 194:3557–3566.
   PubMed Web of Science ®Google Scholar
• Lu YJ, et al. 2008. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog. 4:e1000159.
   PubMed Web of Science ®Google Scholar
• Lv X, Song H, Yang J, Li T, Xi T, Xing Y. 2014. A multi-epitope vaccine CTB-UE relieves Helicobacter pylori-induced gastric inflammatory reaction via up-regulating microRNA-155 to inhibit Th17 response in C57/BL6 mice model. Hum Vaccin Immunother. 10:3561–3569.
   PubMed Web of Science ®Google Scholar
• Lyadova IV, Panteleev AV. 2015. Th1 and Th17 cells in tuberculosis: protection, pathology, and biomarkers. Mediat Inflamm. 2015:854507.
   PubMed Web of Science ®Google Scholar
• Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM. 2013. Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection. Infect Immun. 81:4478–4489.
   PubMed Web of Science ®Google Scholar
• McAleer JP, Kolls JK. 2014. Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense. Immunol Rev. 260:129–144.
   PubMed Web of Science ®Google Scholar
• McCuaig S, Martin JG. 2013. How the airway smooth muscle in cystic fibrosis reacts in proinflammatory conditions: implications for airway hyper-responsiveness and asthma in cystic fibrosis. Lancet Respir Med. 1:137–147.
   PubMed Web of Science ®Google Scholar
• Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB, Wong CH, Schneider E, Dy M, Leite-de-Moraes MC. 2007. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med. 204:995–1001.
   PubMed Web of Science ®Google Scholar
• Milano M, Moraes MO, Rodenbusch R, Carvalho CX, Delcroix M, Mousquer G, Laux da Costa L, Unis G, Dalla Costa ER, Rossetti ML. 2016. Single nucleotide polymorphisms in IL17A and IL6 are associated with decreased risk for pulmonary tuberculosis in Southern Brazilian population. PLoS One. 11:e0147814.
   PubMed Web of Science ®Google Scholar
• Miller LS, Cho JS. 2011. Immunity against Staphylococcus aureus cutaneous infections. Nat Rev Immunol. 11:505–518.
   PubMed Web of Science ®Google Scholar
• Miossec P. 2017. Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice. RMD Open. 3:e000284
   PubMed Web of Science ®Google Scholar
• Monin L, Griffiths KL, Slight S, Lin Y, Rangel-Moreno J, Khader SA. 2015. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol. 8:1099–1109.
   PubMed Web of Science ®Google Scholar
• Montgomery CP, Daniels M, Zhao F, Alegre ML, Chong AS, Daum RS. 2014. Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun. 82:2125–2134.
   PubMed Web of Science ®Google Scholar
• Morrison PJ, Ballantyne SJ, Macdonald SJ, Moore JW, Jenkins D, Wright JF, Fouser LA, Kullberg MC. 2015. Differential requirements for IL-17A and IL-22 in cecal versus colonic inflammation induced by Helicobacter hepaticus. Am J Pathol. 185:3290–3303.
   PubMed Web of Science ®Google Scholar
• Morrison PJ, Bending D, Fouser LA, Wright JF, Stockinger B, Cooke A, Kullberg MC. 2013. Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation. Mucosal Immunol. 6:1143–1156.
   PubMed Web of Science ®Google Scholar
• Mourik BC, Lubberts E, de Steenwinkel JEM, Ottenhoff THM, Leenen PJM. 2017. Interactions between Type 1 interferons and the Th17 response in tuberculosis: lessons learned from autoimmune diseases. Front Immunol. 8:294.
   PubMed Web of Science ®Google Scholar
• Moyat M, Bouzourene H, Ouyang W, Iovanna J, Renauld JC, Velin D. 2017. IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice. Mucosal Immunol. 10:271–281.
   PubMed Web of Science ®Google Scholar
• Munari F, Fassan M, Capitani N, Codolo G, Vila-Caballer M, Pizzi M, Rugge M, Della Bella C, Troilo A, D'Elios S, et al. 2014. Cytokine BAFF released by Helicobacter pylori-infected macrophages triggers the Th17 response in human chronic gastritis. J Immunol. 193:5584–5594.
   PubMed Web of Science ®Google Scholar
• Murphy AG, O'Keeffe KM, Lalor SJ, Maher BM, Mills KH, McLoughlin RM. 2014. Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection. J Immunol. 192:3697–3708.
   PubMed Web of Science ®Google Scholar
• Myles IA, Fontecilla NM, Valdez PA, Vithayathil PJ, Naik S, Belkaid Y, Ouyang W, Datta SK. 2013. Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nat Immunol. 14:804–811.
   PubMed Web of Science ®Google Scholar
• Nakada TA, Russell JA, Boyd JH, Walley KR. 2011. IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care. 15:R254.
   PubMed Web of Science ®Google Scholar
• Narita K, Hu DL, Asano K, Nakane A. 2015. Vaccination with non-toxic mutant toxic shock syndrome toxin-1 induces IL-17-dependent protection against Staphylococcus aureus infection. Pathog Dis. 73:ftv023.
   PubMed Web of Science ®Google Scholar
• Newcomb DC, Boswell MG, Huckabee MM, Goleniewska K, Dulek DE, Reiss S, Lukacs NW, Kolls JK, Peebles RS, Jr. 2012. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol. 188:1027–1035.
   PubMed Web of Science ®Google Scholar
• Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS, Jr. 2013. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. Am J Respir Cell Mol Biol. 48:711–716.
   PubMed Web of Science ®Google Scholar
• Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS. Jr. 2009. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol. 182:5317–5321.
   PubMed Web of Science ®Google Scholar
• Nurjadi D, Kain M, Marcinek P, Gaile M, Heeg K, Zanger P. 2016. Ratio of T-helper type 1 (Th1) to Th17 cytokines in whole blood is associated with human β-defensin 3 expression in skin and persistent Staphylococcus aureus nasal carriage. J Infect Dis. 214:1744–1751.
   PubMed Web of Science ®Google Scholar
• Ocejo-Vinyals JG, de Mateo EP, Hoz MA, Arroyo JL, Aguero R, Ausin F, Farinas MC. 2013. The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain. Cytokine. 64:58–61.
   PubMed Web of Science ®Google Scholar
• Okada S, Puel A, Casanova JL, Kobayashi M. 2016. Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. Clin Transl Immunology. 5:e114.
   PubMed Web of Science ®Google Scholar
• Okamoto Yoshida Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, et al. 2010. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol. 184:4414–4422.
   PubMed Web of Science ®Google Scholar
• Onishi RM, Gaffen SL. 2010. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology. 129:311–321.
   PubMed Web of Science ®Google Scholar
• Pan T, Tan R, Li M, Liu Z, Wang X, Tian L, Liu J, Qu H. 2016. IL17-producing γδ T cells may enhance humoral immunity during pulmonary Pseudomonas aeruginosa infection in mice. Front Cell Infect Microbiol. 6:170.
   PubMed Web of Science ®Google Scholar
• Papp KA, Langley RG, Sigurgeirsson B, Abe M, Baker DR, Konno P, Haemmerle S, Thurston HJ, Papavassilis C, Richards HB. 2013. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol. 168:412–421.
   PubMed Web of Science ®Google Scholar
• Papp KA, Leonardi C, Menter A, Ortonne JP, Krueger JG, Kricorian G, Aras G, Li J, Russell CB, Thompson EH, et al. 2012. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med. 366:1181–1189.
   PubMed Web of Science ®Google Scholar
• Pappu R, Ramirez-Carrozzi V, Sambandam A. 2011. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology. 134:8–16.
   PubMed Web of Science ®Google Scholar
• Pappu R, Rutz S, Ouyang W. 2012. Regulation of epithelial immunity by IL-17 family cytokines. Trends Immunol. 33:343–349.
   PubMed Web of Science ®Google Scholar
• Park JH, Jeong SY, Choi AJ, Kim SJ. 2015. Lipopolysaccharide directly stimulates Th17 differentiation in vitro modulating phosphorylation of RelB and NF-κB1. Immunol Lett. 165:10–19.
   PubMed Web of Science ®Google Scholar
• Passos ST, Silver JS, O'Hara AC, Sehy D, Stumhofer JS, Hunter CA. 2010. IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J Immunol. 184:1776–1783.
   PubMed Web of Science ®Google Scholar
• Patel DD, Kuchroo VK. 2015. Th17 cell pathway in human immunity: lessons from genetics and therapeutic interventions. Immunity. 43:1040–1051.
   PubMed Web of Science ®Google Scholar
• Patras KA, Rosler B, Thoman ML, Doran KS. 2015. Characterization of host immunity during persistent vaginal colonization by Group B Streptococcus. Mucosal Immunol. 8:1339–1348.
   Google Scholar
• Peng R, Yue J, Han M, Zhao Y, Liu L, Liang L. 2013. The IL-17F sequence variant is associated with susceptibility to tuberculosis. Gene. 515:229–232.
   PubMed Web of Science ®Google Scholar
• Pfeifer P, Voss M, Wonnenberg B, Hellberg J, Seiler F, Lepper PM, Bischoff M, Langer F, Schäfers HJ, Menger MD, et al. 2013. IL-17C is a mediator of respiratory epithelial innate immune response. Am J Respir Cell Mol Biol. 48:415–421.
   PubMed Web of Science ®Google Scholar
• Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, et al. 2015. Integration of Th17- and lymphotoxin-derived signals initiates meningeal-resident stromal cell remodeling to propagate neuroinflammation. Immunity. 43:1160–1173.
   PubMed Web of Science ®Google Scholar
• Pu Y, Zhang S, Zhou R, Huang N, Li H, Wei W, Li L, Huang C, Yang J, Li Z. 2016. IL-17A up-regulates expression of endothelial tissue factor in liver cirrhosis via the ROS/p38 signal pathway. Biochem Biophys Res Commun. 470:41–47.
   PubMed Web of Science ®Google Scholar
• Puig L. 2017. Brodalumab: the first anti-IL-17 receptor agent for psoriasis. Drugs Today. 53:283–297.
   PubMed Web of Science ®Google Scholar
• Qian X, Chen H, Wu X, Hu L, Huang Q, Jin Y. 2017. Interleukin-17 acts as double-edged sword in anti-tumor immunity and tumorigenesis. Cytokine. 89:34–44.
   PubMed Web of Science ®Google Scholar
• Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D, Nussenblatt RB, Caspi RR. 2008. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol. 180:5167–5171.
   PubMed Web of Science ®Google Scholar
• Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, Hackney J, Kim J, Zhou M, Lai J, et al. 2011. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol. 12:1159–1166.
   PubMed Web of Science ®Google Scholar
• Rich P, Sigurgeirsson B, Thaci D, Ortonne JP, Paul C, Schopf RE, Morita A, Roseau K, Harfst E, Guettner A, et al. 2013. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol. 168:402–411.
   PubMed Web of Science ®Google Scholar
• Rolandelli A, Hernandez Del Pino RE, Pellegrini JM, Tateosian NL, Amiano NO, de la Barrera S, Casco N, Gutierrez M, Palmero DJ, Garcia VE. 2017. The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina. Sci Rep. 7:40666.
   PubMed Web of Science ®Google Scholar
• Sallin MA, Sakai S, Kauffman KD, Young HA, Zhu J, Barber DL. 2017. Th1 differentiation drives the accumulation of intravascular, non-protective CD4 T cells during tuberculosis. Cell Rep. 18:3091–3104.
   PubMed Web of Science ®Google Scholar
• Sanford M, McKeage K. 2015. Secukinumab: first global approval. Drugs. 75:329–338.
   PubMed Web of Science ®Google Scholar
• Saraiva AM, Alves e Silva MR, Correia Silva Jde F, da Costa JE, Gollob KJ, Dutra WO, Moreira PR. 2013. Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis. Hum Immunol. 74:207–214.
   PubMed Web of Science ®Google Scholar
• Seelige R, Washington A, Jr, Bui JD. 2017. The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance. Cytokine. 91:10–12.
   PubMed Web of Science ®Google Scholar
• Segueni N, Tritto E, Bourigault ML, Rose S, Erard F, Le Bert M, Jacobs M, Di Padova F, Stiehl DP, Moulin P, et al. 2016. Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization. Sci Rep. 6:36923.
   PubMedGoogle Scholar
• Serrano C, Wright SW, Bimczok D, Shaffer CL, Cover TL, Venegas A, Salazar MG, Smythies LE, Harris PR, Smith PD. 2013. Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children. Mucosal Immunol. 6:950–959.
   PubMed Web of Science ®Google Scholar
• Shi GC, Zhang LG. 2015. Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis. Genet Mol Res. 14:8526–8531.
   PubMed Web of Science ®Google Scholar
• Shi Y, Liu XF, Zhuang Y, Zhang JY, Liu T, Yin Z, Wu C, Mao XH, Jia KR, Wang FJ, et al. 2010. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J Immunol. 184:5121–5129.
   PubMed Web of Science ®Google Scholar
• Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. 2007. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol. 178:4466–4472.
   PubMed Web of Science ®Google Scholar
• Silverpil E, Wright AK, Hansson M, Jirholt P, Henningsson L, Smith ME, Gordon SB, Iwakura Y, Gjertsson I, Glader P, et al. 2013. Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation. Innate Immun. 19:479–492.
   PubMed Web of Science ®Google Scholar
• Sivick KE, Schaller MA, Smith SN, Mobley HL. 2010. The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection. J Immunol. 184:2065–2075.
   PubMed Web of Science ®Google Scholar
• Sjokvist Ottsjo L, Flach CF, Nilsson S, Malefyt Rde W, Walduck AK, Raghavan S. 2015. Defining the roles of IFN-γ and IL-17A in inflammation and protection against Helicobacter pylori infection. PLoS One. 10:e0131444.
   PubMed Web of Science ®Google Scholar
• Soltesz B, Toth B, Sarkadi AK, Erdos M, Marodi L. 2015. The evolving view of IL-17-mediated immunity in defense against mucocutaneous candidiasis in humans. Int Rev Immunol. 34:348–363.
   PubMed Web of Science ®Google Scholar
• Song X, Qian Y. 2013. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal. 25:2335–2347.
   PubMed Web of Science ®Google Scholar
• Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol. 12:1151–1158.
   PubMed Web of Science ®Google Scholar
• Sparber F, LeibundGut-Landmann S. 2015. Interleukin 17-mediated host defense against Candida albicans. Pathogens. 4:606–619.
   PubMed Web of Science ®Google Scholar
• St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, et al. 2017. An ocular commensal protects against corneal infection by driving an interleukin-17 response from mucosal gammadelta T cells. Immunity. 47:148–158.
   PubMed Web of Science ®Google Scholar
• Stappers MH, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LA, Gyssens IC. 2014. Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections. Eur J Clin Microbiol Infect Dis. 33:2267–2274.
   PubMed Web of Science ®Google Scholar
• Stockinger B, Omenetti S. 2017. The dichotomous nature of T helper 17 cells. Nat Rev Immunol. 17:535–544.
   PubMed Web of Science ®Google Scholar
• Subbian S, Tsenova L, Kim MJ, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, et al. 2015. Lesion-specific immune response in granulomas of patients with pulmonary tuberculosis: a pilot study. PLoS One. 10:e0132249.
   PubMed Web of Science ®Google Scholar
• Sundac L, Dando SJ, Sullivan MJ, Derrington P, Gerrard J, Ulett GC. 2016. Protein-based profiling of the immune response to uropathogenic Escherichia coli in adult patients immediately following hospital admission for acute cystitis. Pathog Dis. 74:ftw062.
   PubMed Web of Science ®Google Scholar
• Sutton CE, Mielke LA, Mills KH. 2012. IL-17-producing γδ T cells and innate lymphoid cells. Eur J Immunol. 42:2221–2231.
   PubMed Web of Science ®Google Scholar
• Takahashi N, Vanlaere I, de Rycke R, Cauwels A, Joosten LA, Lubberts E, van den Berg WB, Libert C. 2008. IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med. 205:1755–1761.
   PubMed Web of Science ®Google Scholar
• Tan CK, Carey AJ, Cui X, Webb RI, Ipe D, Crowley M, Cripps AW, Benjamin WH Jr, Ulett KB, Schembri MA, et al. 2012. Genome-wide mapping of cystitis due to Streptococcus agalactiae and Escherichia coli in mice identifies a unique bladder transcriptome that signifies pathogen-specific antimicrobial defense against urinary tract infection. Infect Immun. 80:3145–3160.
   PubMed Web of Science ®Google Scholar
• Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jiménez Abreu JA, Mahachai V, Vilaichone RK, Ratanachu-Ek T, Tshering L, et al. 2017. Interleukin-17C in human Helicobacter pylori gastritis. Infect Immun. 85:pii: e00389-17.
   PubMed Web of Science ®Google Scholar
• Taylor PR, Bonfield TL, Chmiel JF, Pearlman E. 2016. Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23-dependent IL-17RC. Clin Immunol. 170:53–60.
   PubMed Web of Science ®Google Scholar
• Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J. 2006. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol. 177:36–39.
   PubMed Web of Science ®Google Scholar
• Ulett GC, Totsika M, Schaale K, Carey AJ, Sweet MJ, Schembri MA. 2013. Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Curr Opin Microbiol. 16:100–107.
   PubMed Web of Science ®Google Scholar
• Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G. 2016. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. Immun Inflamm Dis. 4:401–412.
   PubMed Web of Science ®Google Scholar
• Viladomiu M, Bassaganya-Riera J, Tubau-Juni N, Kronsteiner B, Leber A, Philipson CW, Zoccoli-Rodriguez V, Hontecillas R. 2017. Cooperation of gastric mononuclear phagocytes with Helicobacter pylori during colonization. J Immunol. 198:3195–3204.
   PubMed Web of Science ®Google Scholar
• Vuononvirta J, Peltola V, Ilonen J, Mertsola J, He Q. 2015. The gene polymorphism of IL-17 G-152A is associated with increased colonization of Streptococcus pneumoniae in young Finnish children. Pediatr Infect Dis J. 34:928–932.
   PubMed Web of Science ®Google Scholar
• Wang B, Dileepan T, Briscoe S, Hyland KA, Kang J, Khoruts A, Cleary PP. 2010. Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection. Proc Natl Acad Sci USA. 107:5937–5942.
   PubMed Web of Science ®Google Scholar
• Wang M, Xu G, Lu L, Xu K, Chen Y, Pan H, Burstrom B, Burstrom K, Wang J. 2016. Genetic polymorphisms of IL-17A, IL-17F, TLR4 and miR-146a in association with the risk of pulmonary tuberculosis. Sci Rep. 6:28586.
   PubMed Web of Science ®Google Scholar
• Wang X, Chan CC, Yang M, Deng J, Poon VK, Leung VH, Ko KH, Zhou J, Yuen KY, Zheng BJ, Lu L. 2011. A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection. Cell Mol Immunol. 8:462–468.
   PubMed Web of Science ®Google Scholar
• Weber A, Zimmermann C, Mausberg AK, Dehmel T, Kieseier BC, Hartung HP, Hofstetter HH. 2016. Pseudomonas aeruginosa and its bacterial components influence the cytokine response in thymocytes and splenocytes. Infect Immun. 84:1413–1423.
   PubMed Web of Science ®Google Scholar
• Wonnenberg B, Jungnickel C, Honecker A, Wolf L, Voss M, Bischoff M, Tschernig T, Herr C, Bals R, Beisswenger C. 2016. IL-17A attracts inflammatory cells in murine lung infection with P. aeruginosa. Innate Immun. 22:620–625.
   PubMed Web of Science ®Google Scholar
• Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. 2013. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. 496:513–517.
   PubMed Web of Science ®Google Scholar
• Xu X, Shao B, Wang R, Zhou S, Tang Z, Lu W, Xiong S. 2014. Role of Interleukin-17 in defense against Pseudomonas aeruginosa infection in lungs. Int J Clin Exp Med. 7:809–816.
   PubMed Web of Science ®Google Scholar
• Yan X, Shichita T, Katsumata Y, Matsuhashi T, Ito H, Ito K, Anzai A, Endo J, Tamura Y, Kimura K, et al. 2012. Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction. J Am Heart Assoc. 1:e004408.
   PubMed Web of Science ®Google Scholar
• Yan Z, Yang J, Hu R, Hu X, Chen K. 2016. Acinetobacter baumannii infection and IL-17 mediated immunity. Mediat Inflamm. 2016:9834020.
   PubMed Web of Science ®Google Scholar
• Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, Cohen JI, Spriggs MK. 1995. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 3:811–821.
   PubMed Web of Science ®Google Scholar
• Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, Summer WR, Schwarzenberger P, Shellito JE, Kolls JK. 2001a. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol. 25:335–340.
   PubMed Web of Science ®Google Scholar
• Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, et al. 2001b. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 194:519–527.
   PubMed Web of Science ®Google Scholar
• Yu JJ, Gaffen SL. 2008. Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. Front Biosci. 13:170–177.
   PubMed Web of Science ®Google Scholar
• Zacarias JM, Sippert EA, Tsuneto PY, Visentainer JE, de Oliveira e Silva C, Sell AM. 2015. The influence of interleukin 17A and IL17F polymorphisms on chronic periodontitis disease in Brazilian patients. Mediators Inflamm. 2015:147056.
   PubMedGoogle Scholar
• Zaidi TS, Zaidi T, Pier GB, Priebe GP. 2012. Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology. Infect Immun. 80:3706–3712.
   PubMed Web of Science ®Google Scholar
• Zenobia C, Hajishengallis G. 2015. Basic biology and role of interleukin-17 in immunity and inflammation. Periodontol 2000. 69:142–159.
   PubMed Web of Science ®Google Scholar
• Zhao J, Lloyd CM, Noble A. 2013. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol. 6:335–346.
   PubMed Web of Science ®Google Scholar
• Zhao J, Wen C, Li M. 2016. Association analysis of interleukin-17 gene polymorphisms with the risk susceptibility to tuberculosis. Lung. 194:459–467.
   PubMed Web of Science ®Google Scholar
• Zhou SF, Yuan J, Liao MY, Xia N, Tang TT, Li JJ, Jiao J, Dong WY, Nie SF, Zhu ZF, et al. 2014. IL-17A promotes ventricular remodeling after myocardial infarction. J Mol Med. 92:1105–1116.
   PubMed Web of Science ®Google Scholar
• Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F. 2012. Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. Nature. 484:514–518.
   PubMed Web of Science ®Google Scholar