Nitrogen metabolism in cyanobacteria: metabolic and molecular control, growth consequences and biotechnological applications

References

• Aichi M, Takatani N, Omata T. 2001. Role of NtcB in activation of nitrate assimilation genes in the cyanobacterium Synechocystis sp. strain PCC 6803. J Bacteriol. 183:5840–5847.
   PubMed Web of Science ®Google Scholar
• Alfonso M, Perewoska I, Kirilovsky D. 2001. Redox control of ntcA gene expression in Synechocystis sp. PCC 6803. Nitrogen availability and electron transport regulate the levels of the NtcA protein. Plant Physiol. 125:969–981.
   PubMed Web of Science ®Google Scholar
• Allen AE, Dupont CL, Oborník M, Horák A, Nunes-Nesi A, McCrow JP, Zheng H, Johnson DA, Hu H, Fernie AR. 2011. Evolution and metabolic significance of the urea cycle in photosynthetic diatoms. Nature. 473:203–207.
   PubMed Web of Science ®Google Scholar
• Altermann W, Kazmierczak J. 2003. Archean microfossils: a reappraisal of early life on Earth. Res Microbiol. 154:611–617.
   PubMed Web of Science ®Google Scholar
• Antia N, Harrison P, Oliveira L. 1991. The role of dissolved organic nitrogen in phytoplankton nutrition, cell biology and ecology. Phycologia. 30:1–89.
   Web of Science ®Google Scholar
• Asato Y. 2003. Toward an understanding of cell growth and the cell division cycle of unicellular photoautotrophic cyanobacteria. Cell Mol Life Sci. 60:663–687.
   PubMed Web of Science ®Google Scholar
• Asayama M, Imamura S. 2008. Stringent promoter recognition and autoregulation by the group 3 σ-factor SigF in the cyanobacterium Synechocystis sp. strain PCC 6803. Nucleic Acids Res. 36:5297–5305.
   PubMed Web of Science ®Google Scholar
• Azuma M, Osanai T, Hirai MY, Tanaka K. 2011. A response regulator Rre37 and an RNA polymerase sigma factor SigE represent two parallel pathways to activate sugar catabolism in a cyanobacterium Synechocystis sp. PCC 6803. Plant Cell Physiol. 52:404–412.
   PubMed Web of Science ®Google Scholar
• Badger MR, Price GD, Long BM, Woodger FJ. 2006. The environmental plasticity and ecological genomics of the cyanobacterial CO2 concentrating mechanism. J Exp Bot. 57:249–265.
   PubMed Web of Science ®Google Scholar
• Bandyopadhyay A, Elvitigala T, Welsh E, Stöckel J, Liberton M, Min H, Sherman LA, Pakrasi HB. 2011. Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing cyanobacteria. mBio. 2:e00214–e00211.
   PubMed Web of Science ®Google Scholar
• Beck C, Hertel S, Rediger A, Lehmann R, Wiegard A, Kölsch A, Heilmann B, Georg J, Hess WR, Axmann IM. 2014. Daily expression pattern of protein-encoding genes and small noncoding RNAs in Synechocystis sp. strain PCC 6803. Appl Environ Microbiol. 80:5195–5206.
   PubMed Web of Science ®Google Scholar
• Beck C, Knoop H, Axmann IM, Steuer R. 2012. The diversity of cyanobacterial metabolism: genome analysis of multiple phototrophic microorganisms. BMC Genomics. 13:56.
   PubMed Web of Science ®Google Scholar
• Becker EW. 2007. Micro-algae as a source of protein. Biotechnol Adv. 25:207–210.
   PubMed Web of Science ®Google Scholar
• Bekker A, Holland HD, Wang PL, Rumble D, Stein HJ, Hannah JL, Coetzee LL, Beukes NJ. 2004. Dating the rise of atmospheric oxygen. Nature. 427:117–120.
   PubMed Web of Science ®Google Scholar
• Berg J, Tymoczko J, Stryer L. 2002. The glyoxylate cycle enables plants and bacteria to grow on acetate. Biochemistry (Mosc). 5th ed. New York: WH Freeman Publisher. http://www.ncbi.nlm.nih.gov/books/NBK22383.
   Google Scholar
• Bergman B, Gallon JR, Rai AN, Stal LJ. 1997. N2 fixation by non-heterocystous cyanobacteria. FEMS Microbiol Rev. 19:139–185.
   Web of Science ®Google Scholar
• Bergman B, Sandh G, Lin S, Larsson J, Carpenter EJ. 2013. Trichodesmium—a widespread marine cyanobacterium with unusual nitrogen fixation properties. FEMS Microbiol Rev. 37:286–302.
   PubMed Web of Science ®Google Scholar
• Berman-Frank I, Lundgren P, Chen Y-B, Küpper H, Kolber Z, Bergman B, Falkowski P. 2001. Segregation of nitrogen fixation and oxygenic photosynthesis in the marine cyanobacterium Trichodesmium. Science. 294:1534–1537.
   PubMed Web of Science ®Google Scholar
• Berman-Frank I, Lundgren P, Falkowski P. 2003. Nitrogen fixation and photosynthetic oxygen evolution in cyanobacteria. Res Microbiol. 154:157–164.
   PubMed Web of Science ®Google Scholar
• Bird C, Wyman M. 2003. Nitrate/nitrite assimilation system of the marine picoplanktonic cyanobacterium Synechococcus sp. strain WH 8103: effect of nitrogen source and availability on gene expression. Appl Environ Microbiol. 69:7009–7018.
   PubMed Web of Science ®Google Scholar
• Bradley RW, Bombelli P, Lea-Smith DJ, Howe CJ. 2013. Terminal oxidase mutants of the cyanobacterium Synechocystis sp. PCC 6803 show increased electrogenic activity in biological photo-voltaic systems. Phys Chem Chem Phys. 15:13611–13618.
   PubMed Web of Science ®Google Scholar
• Cavalcanti JHF, Esteves-Ferreira AA, Quinhones CGS, Pereira-Lima IA, Nunes-Nesi A, Fernie AR, Araújo WL. 2014. Evolution and functional implications of the tricarboxylic acid cycle as revealed by phylogenetic analysis. Genome Biol Evol. 6:2830–2848.
   PubMed Web of Science ®Google Scholar
• Chang Y, Takatani N, Aichi M, Maeda S-i, Omata T. 2013. Evaluation of the effects of PII deficiency and the toxicity of PipX on growth characteristics of the PII-less mutant of the cyanobacterium Synechococcus elongatus. Plant Cell Physiol. 54:1504–1514.
   PubMed Web of Science ®Google Scholar
• Chávez S, Lucena JM, Reyes JC, Florencio FJ, Candau P. 1999. The presence of glutamate dehydrogenase is a selective advantage for the cyanobacterium Synechocystis sp. strain PCC 6803 under nonexponential growth conditions. J Bacteriol. 181:808–813.
   PubMed Web of Science ®Google Scholar
• Chávez S, Reyes JC, Chauvat F, Florencio FJ, Candau P. 1995. The NADP-glutamate dehydrogenase of the cyanobacterium Synechocystis 6803: cloning, transcriptional analysis and disruption of the gdhA gene. Plant Mol Biol. 28:173–188.
   PubMed Web of Science ®Google Scholar
• Chellamuthu VR, Alva V, Forchhammer K. 2013. From cyanobacteria to plants: conservation of PII functions during plastid evolution. Planta. 237:451–462.
   PubMed Web of Science ®Google Scholar
• Crespo JL, García-Domínguez M, Florencio FJ. 1998. Nitrogen control of the glnN gene that codes for GS type III, the only glutamine synthetase in the cyanobacterium Pseudanabaena sp. PCC 6903. Mol Microbiol. 30:1101–1112.
   PubMed Web of Science ®Google Scholar
• Díaz-Troya S, López-Maury L, Sánchez-Riego AM, Roldán M, Florencio FJ. 2014. Redox regulation of glycogen biosynthesis in the cyanobacterium Synechocystis sp. PCC 6803: analysis of the AGP and glycogen synthases. Mol Plant. 7:87–100.
   PubMed Web of Science ®Google Scholar
• Dutta D, De D, Chaudhuri S, Bhattacharya S. 2005. Hydrogen production by cyanobacteria. Microb Cell Fact. 4:36.
   PubMed Web of Science ®Google Scholar
• Eisenberg D, Gill HS, Pfluegl GMU, Rotstein SH. 2000. Structure–function relationships of glutamine synthetases. Biochim Biophys Acta. 1477:122–145.
   PubMed Web of Science ®Google Scholar
• Eley JH. 1988. Glyoxylate cycle enzyme activities in the cyanobacterium Anacystis nidulans. J Phycol. 24:586–588.
   Web of Science ®Google Scholar
• Espinosa J, Castells MA, Laichoubi KB, Contreras A. 2009. Mutations at pipX suppress lethality of PII-deficient mutants of Synechococcus elongatus PCC 7942. J Bacteriol. 191:4863–4869.
   PubMed Web of Science ®Google Scholar
• Espinosa J, Castells MA, Laichoubi KB, Forchhammer K, Contreras A. 2010. Effects of spontaneous mutations in PipX functions and regulatory complexes on the cyanobacterium Synechococcus elongatus strain PCC 7942. Microbiology. 156:1517–1526.
   PubMed Web of Science ®Google Scholar
• Espinosa J, Forchhammer K, Burillo S, Contreras A. 2006. Interaction network in cyanobacterial nitrogen regulation: PipX, a protein that interacts in a 2-oxoglutarate dependent manner with PII and NtcA. Mol Microbiol. 61:457–469.
   PubMed Web of Science ®Google Scholar
• Espinosa J, Forchhammer K, Contreras A. 2007. Role of the Synechococcus PCC 7942 nitrogen regulator protein PipX in NtcA-controlled processes. Microbiology. 153:711–718.
   PubMed Web of Science ®Google Scholar
• Espinosa J, Rodríguez-Mateos F, Salinas P, Lanza VF, Dixon R, de la Cruz F, Contreras A. 2014. PipX, the coactivator of NtcA, is a global regulator in cyanobacteria. Proc Natl Acad Sci USA. 111:E2423–E2430.
   PubMed Web of Science ®Google Scholar
• Esteves-Ferreira AA, Cavalcanti JHF, Vaz MGMV, Alvarenga LV, Nunes-Nesi A, Araújo WL. 2017. Cyanobacterial nitrogenases: phylogenetic diversity, regulation and functional predictions. Genet Mol Biol. 40:261–275.
   PubMed Web of Science ®Google Scholar
• Esteves-Ferreira AA, Inaba M, Obata T, Fort A, Fleming GT, Araújo WL, Fernie AR, Sulpice R. 2017. A novel mechanism, linked to cell density, largely controls cell division in Synechocystis. Plant Physiol. 174:2166–2182.
   PubMed Web of Science ®Google Scholar
• Fay P. 1992. Oxygen relations of nitrogen fixation in cyanobacteria. Microbiol Rev. 56:340–373.
   PubMedGoogle Scholar
• Feria Bourrellier AB, Valot B, Guillot A, Ambard-Bretteville F, Vidal J, Hodges M. 2010. Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit. PNAS. 107:502–507.
   PubMed Web of Science ®Google Scholar
• Finzi-Hart JA, Pett-Ridge J, Weber PK, Popa R, Fallon SJ, Gunderson T, Hutcheon ID, Nealson KH, Capone DG. 2009. Fixation and fate of C and N in the cyanobacterium Trichodesmium using nanometer-scale secondary ion mass spectrometry. PNAS. 106:6345–6350.
   PubMed Web of Science ®Google Scholar
• Florencio FJ, Marqués S, Candau P. 1987. Identification and characterization of a glutamate dehydrogenase in the unicellular cyanobacterium Synechocystis PCC 6803. FEBS Lett. 223:37–41.
   Web of Science ®Google Scholar
• Flores E, Frías JE, Rubio LM, Herrero A. 2005. Photosynthetic nitrate assimilation in cyanobacteria. Photosyn Res. 83:117–133.
   PubMed Web of Science ®Google Scholar
• Flores E, Herrero A. 2005. Nitrogen assimilation and nitrogen control in cyanobacteria. Biochem Soc Trans. 33:164–167.
   PubMed Web of Science ®Google Scholar
• Fokina O, Chellamuthu V-R, Forchhammer K, Zeth K. 2010a. Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus PII signal transduction protein. PNAS. 107:19760–19765.
   PubMed Web of Science ®Google Scholar
• Fokina O, Chellamuthu V-R, Zeth K, Forchhammer K. 2010b. A novel signal transduction protein PII variant from Synechococcus elongatus PCC 7942 indicates a two-step process for NAGK–PII complex formation. J Mol Biol. 399:410–421.
   PubMed Web of Science ®Google Scholar
• Fokina O, Herrmann C, Forchhammer K. 2011. Signal-transduction protein P(II) from Synechococcus elongatus PCC 7942 senses low adenylate energy charge in vitro. Biochem J. 440:147–156.
   PubMed Web of Science ®Google Scholar
• Forcada-Nadal A, Forchhammer K, Rubio V. 2014. SPR analysis of promoter binding of Synechocystis PCC6803 transcription factors NtcA and CRP suggests cross-talk and sheds light on regulation by effector molecules. FEBS Lett. 588:2270–2276.
   PubMed Web of Science ®Google Scholar
• Forcada-Nadal A, Palomino-Schätzlein M, Neira JL, Pineda-Lucena A, Rubio V. 2017. The PipX protein, when not bound to its targets, has its signaling C-terminal helix in a flexed conformation. Biochemistry. 56:3211–3224.
   PubMed Web of Science ®Google Scholar
• Forchhammer K, de Marsac NT. 1995a. Phosphorylation of the PII protein (glnB gene product) in the cyanobacterium Synechococcus sp. strain PCC 7942: analysis of in vitro kinase activity. J Bacteriol. 177:5812–5817.
   PubMed Web of Science ®Google Scholar
• Forchhammer K, de Marsac N. 1995b. Functional analysis of the phosphoprotein PII (glnB gene product) in the cyanobacterium Synechococcus sp. strain PCC 7942. J Bacteriol. 177:2033–2040.
   PubMed Web of Science ®Google Scholar
• Forchhammer K, Hedler A. 1997. Phosphoprotein PII from cyanobacteria-analysis of functional conservation with the PII signal-transduction protein from Escherichia coli. Eur J Biochem. 244:869–875.
   PubMedGoogle Scholar
• Forchhammer K, Lüddecke J. 2016. Sensory properties of the PII signalling protein family. FEBS J. 283:425–437.
   PubMed Web of Science ®Google Scholar
• Forchhammer K. 2004. Global carbon/nitrogen control by PII signal transduction in cyanobacteria: from signals to targets. FEMS Microbiol Rev. 28:319–333.
   PubMed Web of Science ®Google Scholar
• Foster JS, Singh AK, Rothschild LJ, Sherman LA. 2007. Growth-phase dependent differential gene expression in Synechocystis sp. strain PCC 6803 and regulation by a group 2 sigma factor. Arch Microbiol. 187:265–279.
   PubMed Web of Science ®Google Scholar
• Frías JE, Mérida A, Herrero A, Martín-Nieto J, Flores E. 1993. General distribution of the nitrogen control gene ntcA in cyanobacteria. J Bacteriol. 175:5710–5713.
   PubMed Web of Science ®Google Scholar
• Frommeyer M, Wiefel L, Steinbüchel A. 2014. Features of the biotechnologically relevant polyamide family “cyanophycins” and their biosynthesis in prokaryotes and eukaryotes. Crit Rev Biotechnol. 36:153–164.
   Web of Science ®Google Scholar
• García-Domínguez M, Reyes JC, Florencio FJ. 1997. Purification and characterization of a new type of glutamine synthetase from cyanobacteria. Eur J Biochem. 244:258–264.
   PubMedGoogle Scholar
• García-Domínguez M, Reyes JC, Florencio FJ. 2000. NtcA represses transcription of gifA and gifB, genes that encode inhibitors of glutamine synthetase type I from Synechocystis sp. PCC 6803. Mol Microbiol. 35:1192–1201.
   PubMed Web of Science ®Google Scholar
• García-Domínguez M, Florencio FJ. 1997. Nitrogen availability and electron transport control the expression of glnB gene (encoding PII protein) in the cyanobacterium Synechocystis sp. PCC 6803. Plant Mol Biol. 35:723–734.
   PubMed Web of Science ®Google Scholar
• Ge X, Cain K, Hirschberg R. 1990. Urea metabolism and urease regulation in the cyanobacterium Anabaena variabilis. Can J Microbiol. 36:218–222.
   Web of Science ®Google Scholar
• Ginn HP, Pearson LA, Neilan BA. 2010. NtcA from Microcystis aeruginosa PCC 7806 is autoregulatory and binds to the microcystin promoter. Appl Environ Microbiol. 76:4362–4368.
   PubMed Web of Science ®Google Scholar
• González López CV, García MdCC, Fernández FGA, Bustos CS, Chisti Y, Sevilla JMF. 2010. Protein measurements of microalgal and cyanobacterial biomass. Bioresour Technol. 101:7587–7591.
   PubMed Web of Science ®Google Scholar
• Gründel M, Knoop H, Steuer R. 2017. Activity and functional properties of the isocitrate lyase in the cyanobacterium Cyanothece sp. PCC 7424. Microbiology. 163:731–744.
   PubMed Web of Science ®Google Scholar
• Guerreiro AC, Benevento M, Lehmann R, van Breukelen B, Post H, Giansanti P, Altelaar AM, Axmann IM, Heck AJ. 2014. Daily rhythms in the cyanobacterium Synechococcus elongatus probed by high-resolution mass spectrometry-based proteomics reveals a small defined set of cyclic proteins. Mol Cell Proteomics. 13:2042–2055.
   PubMed Web of Science ®Google Scholar
• Guerrero MG, Vega JM, Losada M. 1981. The assimilatory nitrate-reducing system and its regulation. Annu Rev Plant Physiol. 32:169–204.
   Google Scholar
• Harano Y, Suzuki I, Maeda S-i, Kaneko T, Tabata S, Omata T. 1997. Identification and nitrogen regulation of the cyanase gene from the cyanobacteria Synechocystis sp. strain PCC 6803 and Synechococcus sp. strain PCC 7942. J Bacteriol. 179:5744–5750.
   PubMed Web of Science ®Google Scholar
• Hauf W, Schmid K, Gerhardt ECM, Huergo LF, Forchhammer K. 2016. Interaction of the nitrogen regulatory protein GlnB (PII) with biotin carboxyl carrier protein (BCCP) controls acetyl-CoA levels in the cyanobacterium Synechocystis sp. PCC 6803. Front Microbiol. 7:1–14.
   PubMed Web of Science ®Google Scholar
• Heinrich A, Maheswaran M, Ruppert U, Forchhammer K. 2004. The Synechococcus elongatus P signal transduction protein controls arginine synthesis by complex formation with N-acetyl-l-glutamate kinase. Mol Microbiol. 52:1303–1314.
   PubMed Web of Science ®Google Scholar
• Hendry JI, Prasannan CB, Joshi A, Dasgupta S, Wangikar PP. 2016. Metabolic model of Synechococcus sp. PCC 7002: prediction of flux distribution and network modification for enhanced biofuel production. Bioresour Technol. 213:190–197.
   PubMed Web of Science ®Google Scholar
• Herrero A, Muro-Pastor AM, Flores E. 2001. Nitrogen control in cyanobacteria. J Bacteriol. 183:411–425.
   PubMed Web of Science ®Google Scholar
• Hisbergues M, Jeanjean R, Joset F, Tandeau de Marsac N, Bédu S. 1999. Protein PII regulates both inorganic carbon and nitrate uptake and is modified by a redox signal in Synechocystis PCC 6803. FEBS Lett. 463:216–220.
   PubMed Web of Science ®Google Scholar
• Huergo LF, Dixon R. 2015. The emergence of 2-oxoglutarate as a master regulator metabolite. Microbiol Mol Biol Rev. 79:419–435.
   PubMed Web of Science ®Google Scholar
• Irmler A, Forchhammer K. 2001. A PP2C-type phosphatase dephosphorylates the PII signaling protein in the cyanobacterium Synechocystis PCC 6803. PNAS. 98:12978–12983.
   PubMed Web of Science ®Google Scholar
• Jiang F, Wisén S, Widersten M, Bergman B, Mannervik B. 2000. Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library. J Mol Biol. 301:783–793.
   PubMed Web of Science ®Google Scholar
• Kamennaya NA, Chernihovsky M, Post AF. 2008. The cyanate utilization capacity of marine unicellular cyanobacteria. Limnol Oceanogr. 53:2485–2494.
   Web of Science ®Google Scholar
• Kaneko T, Sato S, Kotani H, Tanaka A, Asamizu E, Nakamura Y, Miyajima N, Hirosawa M, Sugiura M, Sasamoto S. 1996. Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res. 3:109–136.
   PubMedGoogle Scholar
• Kirilovsky D. 2007. Photoprotection in cyanobacteria: the orange carotenoid protein (OCP)-related non-photochemical-quenching mechanism. Photosyn Res. 93:7–16.
   PubMed Web of Science ®Google Scholar
• Klähn S, Schaal C, Georg J, Baumgartner D, Knippen G, Hagemann M, Muro-Pastor AM, Hess WR. 2015. The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7. Proc Natl Acad Sci USA. 112:E6243–E6252.
   PubMed Web of Science ®Google Scholar
• Kleiner D. 1981. The transport of NH3 and NH4+ across biological membranes. Biochim Biophys Acta. 639:41–52.
   PubMed Web of Science ®Google Scholar
• Kloft N, Forchhammer K. 2005. Signal transduction protein PII phosphatase PphA is required for light-dependent control of nitrate utilization in Synechocystis sp. strain PCC 6803. J Bacteriol. 187:6683–6690.
   PubMed Web of Science ®Google Scholar
• Kloft N, Rasch G, Forchhammer K. 2005. Protein phosphatase PphA from Synechocystis sp. PCC 6803: the physiological framework of PII-P dephosphorylation. Microbiology. 151:1275–1283.
   PubMed Web of Science ®Google Scholar
• Knoop H, Gründel M, Zilliges Y, Lehmann R, Hoffmann S, Lockau W, Steuer R. 2013. Flux balance analysis of cyanobacterial metabolism: the metabolic network of Synechocystis sp. PCC 6803. PLoS Comput Biol. 9:e1003081.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Rodrı´guez Ro Lara C, Omata T. 1997. Involvement of the C-terminal domain of an ATP-binding subunit in the regulation of the ABC-type nitrate/nitrite transporter of the cyanobacterium Synechococcus sp. strain PCC 7942. J Biol Chem. 272:27197–27201.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Takatani N, Tanigawa M, Omata T. 2005. Posttranslational regulation of nitrate assimilation in the cyanobacterium Synechocystis sp. strain PCC 6803. J Bacteriol. 187:498–506.
   PubMed Web of Science ®Google Scholar
• Komárek J, Kastovský J. 2003. Coincidences of structural and molecular characters in evolutionary lines of cyanobacteria. Algo Stud. 109:305–325.
   Google Scholar
• Kornberg H. 2000. Krebs and his trinity of cycles. Nat Rev Mol Cell Biol. 1:225–228.
   PubMed Web of Science ®Google Scholar
• Kuniyoshi TM, Gonzalez A, Lopez-Gomollon S, Valladares A, Bes MT, Fillat MF, Peleato ML. 2011. 2-Oxoglutarate enhances NtcA binding activity to promoter regions of the microcystin synthesis gene cluster. FEBS Lett. 585:3921–3926.
   PubMed Web of Science ®Google Scholar
• Labella JI, Obrebska A, Espinosa J, Salinas P, Forcada-Nadal A, Tremiño L, Rubio V, Contreras A. 2016. Expanding the cyanobacterial nitrogen regulatory network: the GntR-like regulator PlmA interacts with the PII-PipX complex. Front Microbiol. 7:1677.
   PubMed Web of Science ®Google Scholar
• Laichoubi KB, Beez S, Espinosa J, Forchhammer K, Contreras A. 2011. The nitrogen interaction network in Synechococcus WH5701, a cyanobacterium with two PipX and two PII-like proteins. Microbiology. 157:1220–1228.
   PubMed Web of Science ®Google Scholar
• Laichoubi KB, Espinosa J, Castells MA, Contreras A. 2012. Mutational analysis of the cyanobacterial nitrogen regulator PipX. PLoS One. 7:e35845.
   PubMed Web of Science ®Google Scholar
• Lee H-M, Flores E, Herrero A, Houmard J, Tandeau de Marsac N. 1998. A role for the signal transduction protein PII in the control of nitrate/nitrite uptake in a cyanobacterium. FEBS Lett. 427:291–295.
   PubMed Web of Science ®Google Scholar
• Lee H-M, Vázquez-Bermúdez MF, de Marsac NT. 1999. The global nitrogen regulator NtcA regulates transcription of the signal transducer PII (GlnB) and influences its phosphorylation level in response to nitrogen and carbon supplies in the cyanobacterium Synechococcus sp. strain PCC 7942. J Bacteriol. 181:2697–2702.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhang H, Niedzwiedzki DM, Prado M, He G, Gross ML, Blankenship RE. 2013. Phycobilisomes supply excitations to both photosystems in a megacomplex in cyanobacteria. Science. 342:1104–1107.
   PubMed Web of Science ®Google Scholar
• Llácer JL, Contreras A, Forchhammer K, Marco-Marín C, Gil-Ortiz F, Maldonado R, Fita I, Rubio V. 2007. The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine. PNAS. 104:17644–17649.
   PubMed Web of Science ®Google Scholar
• Llácer JL, Espinosa J, Castells MA, Contreras A, Forchhammer K, Rubio V. 2010. Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII. PNAS. 107:15397–15402.
   PubMed Web of Science ®Google Scholar
• Llácer JL, Fita I, Rubio V. 2008. Arginine and nitrogen storage. Curr Opin Struct Biol. 18:673–681.
   PubMed Web of Science ®Google Scholar
• Lüddecke J, Forchhammer K. 2013. From PII signaling to metabolite sensing: a novel 2-oxoglutarate sensor that details PII-NAGK complex formation. PLoS One. 8:e83181.
   PubMed Web of Science ®Google Scholar
• Lüddecke J, Francois L, Spät P, Watzer B, Chilczuk T, Poschet G, Hell R, Radlwimmer B, Forchhammer K. 2017. PII protein-derived FRET sensors for quantification and live-cell imaging of 2-oxoglutarate. Sci Rep. 7:1–13.
   PubMed Web of Science ®Google Scholar
• Ludwig M, Bryant DA. 2012. Acclimation of the global transcriptome of the cyanobacterium Synechococcus sp. strain PCC 7002 to nutrient limitations and different nitrogen sources. Front Microbiol. 3:1–15.
   PubMed Web of Science ®Google Scholar
• Luque I, Flores E, Herrero A. 1994a. Molecular mechanism for the operation of nitrogen control in cyanobacteria. EMBO J. 13:2862–2869.
   PubMed Web of Science ®Google Scholar
• Luque I, Flores E, Herrero A. 1994b. Nitrate and nitrite transport in the cyanobacterium Synechococcus sp. PCC 7942 are mediated by the same permease. Biochim Biophys Acta. 1184:296–298.
   Web of Science ®Google Scholar
• Luque I, Zabulon G, Contreras A, Houmard J. 2001. Convergence of two global transcriptional regulators on nitrogen induction of the stress-acclimation gene nblA in the cyanobacterium Synechococcus sp. PCC 7942. Mol Microbiol. 41:937–947.
   PubMed Web of Science ®Google Scholar
• Ma C-W, Lüddecke J, Forchhammer K, Zeng A-P. 2014. Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of P(II) protein. Proteins. 82:1048–1059.
   PubMed Web of Science ®Google Scholar
• Maeda S-i, Murakami A, Ito H, Tanaka A, Omata T. 2015. Functional characterization of the FNT family nitrite transporter of marine picocyanobacteria. Life. 5:432–446.
   PubMedGoogle Scholar
• Maeda S-i, Omata T. 2009. Nitrite transport activity of the ABC-type cyanate transporter of the cyanobacterium Synechococcus elongatus. J Bacteriol. 191:3265–3272.
   PubMed Web of Science ®Google Scholar
• Maheswaran M, Ziegler K, Lockau W, Hagemann M, Forchhammer K. 2006. PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803. J Bacteriol. 188:2730–2734.
   PubMed Web of Science ®Google Scholar
• Marino GT, Asato Y. 1986. Characterization of cell cycle events in the dark in Anacystis nidulans. Microbiology. 132:2123–2127.
   Web of Science ®Google Scholar
• McCormick AJ, Bombelli P, Lea-Smith DJ, Bradley RW, Scott AM, Fisher AC, Smith AG, Howe CJ. 2013. Hydrogen production through oxygenic photosynthesis using the cyanobacterium Synechocystis sp. PCC 6803 in a bio-photoelectrolysis cell (BPE) system. Energy Environ Sci. 6:2682–2690.
   Web of Science ®Google Scholar
• Mehta PK, Hale TI, Christen P. 1993. Aminotransferases: demonstration of homology and division into evolutionary subgroups. Eur J Biochem. 214:549–561.
   PubMedGoogle Scholar
• Mitamura O, Kawashima M, Maeda H. 2000. Urea degradation by picophytoplankton in the euphotic zone of Lake Biwa. Limnology. 1:19–26.
   Google Scholar
• Mitamura O, Saijo Y. 1980. In situ measurement of the urea decomposition rate and its turnover rate in the Pacific Ocean. Mar Biol. 58:147–152.
   Web of Science ®Google Scholar
• Montesinos ML, Muro-Pastor AMa, Herrero A, Flores E. 1998. Ammonium/methylammonium permeases of a cyanobacterium: identification and analysis of three nitrogen-regulated amt genes in Synechocystis sp. J Biol Chem. 273:31463–31470.
   PubMed Web of Science ®Google Scholar
• Mori T, Binder B, Johnson CH. 1996. Circadian gating of cell division in cyanobacteria growing with average doubling times of less than 24 hours. PNAS. 93:10183–10188.
   PubMed Web of Science ®Google Scholar
• Mori T, Johnson CH. 2001. Independence of circadian timing from cell division in cyanobacteria. J Bacteriol. 183:2439–2444.
   PubMed Web of Science ®Google Scholar
• Mullineaux C. 2008. Phycobilisome-reaction centre interaction in cyanobacteria. Photosyn Res. 95:175–182.
   PubMed Web of Science ®Google Scholar
• Muro-Pastor AMa, Herrero A, Flores E. 2001. Nitrogen-regulated group 2 sigma factor from Synechocystis sp. strain PCC 6803 involved in survival under nitrogen stress. J Bacteriol. 183:1090–1095.
   PubMed Web of Science ®Google Scholar
• Muro-Pastor MI, Florencio FJ. 2003. Regulation of ammonium assimilation in cyanobacteria. Plant Physiol Biochem. 41:595–603.
   Web of Science ®Google Scholar
• Muro-Pastor MI, Reyes JC, Florencio FJ. 1996. The NADP+-isocitrate dehydrogenase gene (icd) is nitrogen regulated in cyanobacteria. J Bacteriol. 178:4070–4076.
   PubMed Web of Science ®Google Scholar
• Muro-Pastor MI, Reyes JC, Florencio FJ. 2005. Ammonium assimilation in cyanobacteria. Photosyn Res. 83:135–150.
   PubMed Web of Science ®Google Scholar
• Navarro F, Chávez S, Candau P, Florencio FJ. 1995. Existence of two ferredoxin-glutamate synthases in the cyanobacterium Synechocystis sp. PCC 6803. Isolation and insertional inactivation of gltB and gltS genes. Plant Mol Biol. 27:753–767.
   PubMed Web of Science ®Google Scholar
• Neilson A, Doudoroff M. 1973. Ammonia assimilation in blue-green algae. Arch Mikrobiol. 89:15–22.
   PubMedGoogle Scholar
• Niu W, Kim Y, Tau G, Heyduk T, Ebright RH. 1996. Transcription activation at class II CAP-dependent promoters: two interactions between CAP and RNA polymerase. Cell. 87:1123–1134.
   PubMed Web of Science ®Google Scholar
• Nogales J, Gudmundsson S, Knight EM, Palsson BO, Thiele I. 2012. Detailing the optimality of photosynthesis in cyanobacteria through systems biology analysis. PNAS. 109:2678–2683.
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Shi W, Takatani N, Aichi M, Maeda S-i, Watanabe S, Yoshikawa H, Omata T. 2011. Regulation of nitrate assimilation in cyanobacteria. J Exp Bot. 62:1411–1424.
   PubMed Web of Science ®Google Scholar
• Ohbayashi R, Watanabe S, Kanesaki Y, Narikawa R, Chibazakura T, Ikeuchi M, Yoshikawa H. 2013. DNA replication depends on photosynthetic electron transport in cyanobacteria. FEMS Microbiol Lett. 344:138–144.
   PubMed Web of Science ®Google Scholar
• Ohbayashi R, Yamamoto J-y, Watanabe S, Kanesaki Y, Chibazakura T, Miyagishima S-y, Yoshikawa H. 2017. Variety of DNA replication activity among cyanobacteria correlates with distinct respiration activity in the dark. Plant Cell Physiol. 58:279–286.
   PubMed Web of Science ®Google Scholar
• Okuhara H, Matsumura T, Fujita Y, Hase T. 1999. Cloning and inactivation of genes encoding ferredoxin- and NADH-dependent glutamate synthases in the cyanobacterium Plectonema boryanum. Imbalances in nitrogen and carbon assimilations caused by deficiency of the ferredoxin-dependent enzyme. Plant Physiol. 120:33–42.
   PubMed Web of Science ®Google Scholar
• Omata T, Andriesse X, Hirano A. 1993. Identification and characterization of a gene cluster involved in nitrate transport in the cyanobacterium Synechococcus sp. PCC7942. Mol Gen Genet. 236:193–202.
   PubMedGoogle Scholar
• Osanai T, Azuma M, Tanaka K. 2007. Sugar catabolism regulated by light- and nitrogen-status in the cyanobacterium Synechocystis sp. PCC 6803. Photochem Photobiol Sci. 6:508–514.
   PubMed Web of Science ®Google Scholar
• Osanai T, Imamura S, Asayama M, Shirai M, Suzuki I, Murata N, Tanaka K. 2006. Nitrogen induction of sugar catabolic gene expression in Synechocystis sp. PCC 6803. DNA Res. 13:185–195.
   PubMed Web of Science ®Google Scholar
• Osanai T, Oikawa A, Iijima H, Kuwahara A, Asayama M, Tanaka K, Ikeuchi M, Saito K, Hirai MY. 2014. Metabolomic analysis reveals rewiring of Synechocystis sp. PCC 6803 primary metabolism by ntcA overexpression. Environ Microbiol. 16:3304–3317.
   PubMed Web of Science ®Google Scholar
• Pando BF, van Oudenaarden A. 2010. Coupling cellular oscillators-circadian and cell division cycles in cyanobacteria. Curr Opin Genet Dev. 20:613–618.
   PubMed Web of Science ®Google Scholar
• Parmar A, Singh NK, Pandey A, Gnansounou E, Madamwar D. 2011. Cyanobacteria and microalgae: a positive prospect for biofuels. Bioresour Technol. 102:10163–10172.
   PubMed Web of Science ®Google Scholar
• Paz-Yepes J, Flores E, Herrero A. 2003. Transcriptional effects of the signal transduction protein P(II) (glnB gene product) on NtcA-dependent genes in Synechococcus sp. PCC 7942. FEBS Lett. 543:42–46.
   PubMed Web of Science ®Google Scholar
• Paz-Yepes J, Herrero A, Flores E. 2007. The NtcA-regulated amtB gene is necessary for full methylammonium uptake activity in the cyanobacterium Synechococcus elongatus. J Bacteriol. 189:7791–7798.
   PubMed Web of Science ®Google Scholar
• Pearce J, Carr NG. 1967. The metabolism of acetate by the blue-green algae, Anabaena variabilis and Anacystis nidulans. J Gen Microbiol. 49:301–313.
   PubMedGoogle Scholar
• Pearce J, Leach C, Carr N. 1969. The incomplete tricarboxylic acid cycle in the blue-green alga Anabaena variabilis. J Gen Microbiol. 55:371–378.
   PubMedGoogle Scholar
• Peschek GA, Obinger C, Paumann M. 2004. The respiratory chain of blue-green algae (cyanobacteria). Physiol Plant. 120:358–369.
   PubMed Web of Science ®Google Scholar
• Pimentel JSM, Giani A. 2014. Microcystin production and regulation under nutrient stress conditions in toxic microcystis strains. Appl Environ Microbiol. 80:5836–5843.
   PubMed Web of Science ®Google Scholar
• Quintero MJ, Montesinos ML, Herrero A, Flores E. 2001. Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence. Genome Res. 11:2034–2040.
   PubMed Web of Science ®Google Scholar
• Quintero MJ, Muro-Pastor AM, Herrero A, Flores E. 2000. Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway. J Bacteriol. 182:1008–1015.
   PubMed Web of Science ®Google Scholar
• Rangel OA, Gómez-Baena G, López-Lozano A, Diez J, García-Fernández JM. 2009. Physiological role and regulation of glutamate dehydrogenase in Prochlorococcus sp. strain MIT9313. Environ Microbiol Rep. 1:56–64.
   PubMed Web of Science ®Google Scholar
• Rastogi RP, Sinha RP, Incharoensakdi A. 2014. The cyanotoxin-microcystins: current overview. Rev Environ Sci Biotechnol. 13:215.
   Web of Science ®Google Scholar
• Rees AP, Woodward EMS, Joint I. 2006. Concentrations and uptake of nitrate and ammonium in the Atlantic Ocean between 60°N and 50°S. Deep Sea Res Part 2 Top Stud Oceanogr. 53:1649–1665.
   Web of Science ®Google Scholar
• Reyes J, Muro-Pastor M, Florencio F. 1997. Transcription of glutamine synthetase genes (glnA and glnN) from the cyanobacterium Synechocystis sp. strain PCC 6803 is differently regulated in response to nitrogen availability. J Bacteriol. 179:2678–2689.
   PubMed Web of Science ®Google Scholar
• Reyes JC, Florencio FJ. 1994. A new type of glutamine synthetase in cyanobacteria: the protein encoded by the glnN gene supports nitrogen assimilation in Synechocystis sp. strain PCC 6803. J Bacteriol. 176:1260–1267.
   PubMed Web of Science ®Google Scholar
• Rodriguez IB, Ho T-Y. 2014. Diel nitrogen fixation pattern of Trichodesmium: the interactive control of light and Ni. Sci Rep. 4:1–5.
   Web of Science ®Google Scholar
• Rubin BE, Wetmore KM, Price MN, Diamond S, Shultzaberger RK, Lowe LC, Curtin G, Arkin AP, Deutschbauer A, Golden SS. 2015. The essential gene set of a photosynthetic organism. Proc Natl Acad Sci USA. 112:E6634–E6643.
   PubMed Web of Science ®Google Scholar
• Ruppert U, Irmler A, Kloft N, Forchhammer K. 2002. The novel protein phosphatase PphA from Synechocystis PCC 6803 controls dephosphorylation of the signalling protein PII. Mol Microbiol. 44:855–864.
   PubMed Web of Science ®Google Scholar
• Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI. 2011. Mutational analysis of the inactivating factors, IF7 and IF17 from Synechocystis sp. PCC 6803: critical role of arginine amino acid residues for glutamine synthetase inactivation. Mol Microbiol. 82:964–975.
   PubMed Web of Science ®Google Scholar
• Sakamoto T, Bryant DA. 2001. Requirement of nickel as an essential micronutrient for the utilization of urea in the marine cyanobacterium Synechococcus sp. PCC 7002. Microb Environ. 16:177–184.
   Google Scholar
• Sakamoto T, Inoue-Sakamoto K, Bryant DA. 1999. A novel nitrate/nitrite permease in the marine cyanobacterium Synechococcus sp. strain PCC 7002. J Bacteriol. 181:7363–7372.
   PubMed Web of Science ®Google Scholar
• Sandh G, Ran L, Xu L, Sundqvist G, Bulone V, Bergman B. 2011. Comparative proteomic profiles of the marine cyanobacterium Trichodesmium erythraeum IMS101 under different nitrogen regimes. Proteomics. 11:406–419.
   PubMed Web of Science ®Google Scholar
• Sant’Anna FH, Trentini DB, de Souto Weber S, Cecagno R, da Silva SC, Schrank IS. 2009. The PII superfamily revised: a novel group and evolutionary insights. J Mol Evol. 68:322–336.
   PubMed Web of Science ®Google Scholar
• Sasaki Y, Nagano Y. 2004. Plant acetyl-CoA carboxylase: structure, biosynthesis, regulation, and gene manipulation for plant breeding. Biosci Biotechnol Biochem. 68:1175–1184.
   PubMed Web of Science ®Google Scholar
• Sauer J, Görl M, Forchhammer K. 1999. Nitrogen starvation in Synechococcus PCC 7942: involvement of glutamine synthetase and NtcA in phycobiliprotein degradation and survival. Arch Microbiol. 172:247–255.
   PubMed Web of Science ®Google Scholar
• Schirrmeister BE, de Vos JM, Antonelli A, Bagheri HC. 2013. Evolution of multicellularity coincided with increased diversification of cyanobacteria and the great oxidation event. PNAS. 110:1791–1796.
   PubMed Web of Science ®Google Scholar
• Schwamborn M. 1998. Chemical synthesis of polyaspartates: a biodegradable alternative to currently used polycarboxylate homo- and copolymers. Polym Degrad Stab. 59:39–45.
   Web of Science ®Google Scholar
• Singh S. 1990. Regulation of urease activity in the cyanobacterium Anabaena doliolum. FEMS Microbiol Lett. 67:79–84.
   Web of Science ®Google Scholar
• Singh S. 1992. Regulation of urease cellular levels in the cyanobacteria Anacystis nidulans and Nostoc muscorum. Biochem Physiol Pflanz. 188:33–38.
   Google Scholar
• Smith AJ, London J, Stanier RY. 1967. Biochemical basis of obligate autotrophy in blue-green algae and Thiobacilli. J Bacteriol. 94:972–983.
   PubMed Web of Science ®Google Scholar
• Stal LJ. 2008. Nitrogen fixation in cyanobacteria. In: Encyclopedia of life sciences (ELS). Chichester: John Wiley & Sons Ltd.; p. 1–8.
   Google Scholar
• Steinhauser D, Fernie AR, Araújo WL. 2012. Unusual cyanobacterial TCA cycles: not broken just different. Trends Plant Sci. 17:503–509.
   PubMed Web of Science ®Google Scholar
• Stephan DP, Ruppel HG, Pistorius EK. 2000. Interrelation between cyanophycin synthesis, l-arginine catabolism and photosynthesis in the cyanobacterium Synechocystis sp. strain PCC 6803. Z Naturforsch C Biosci. 55:927–942.
   PubMed Web of Science ®Google Scholar
• Steuer R, Knoop H, Machné R. 2012. Modelling cyanobacteria: from metabolism to integrative models of phototrophic growth. J Exp Bot. 63:2259–2274.
   PubMed Web of Science ®Google Scholar
• Steunou A-S, Jensen SI, Brecht E, Becraft ED, Bateson MM, Kilian O, Bhaya D, Ward DM, Peters JW, Grossman AR, et al. 2008. Regulation of nif gene expression and the energetics of N2 fixation over the diel cycle in a hot spring microbial mat. ISME J. 2:364–378.
   PubMed Web of Science ®Google Scholar
• Su Z, Olman V, Mao F, Xu Y. 2005. Comparative genomics analysis of NtcA regulons in cyanobacteria: regulation of nitrogen assimilation and its coupling to photosynthesis. Nucleic Acids Res. 33:5156–5171.
   PubMed Web of Science ®Google Scholar
• Suzuki I, Horie N, Sugiyama T, Omata T. 1995. Identification and characterization of two nitrogen-regulated genes of the cyanobacterium Synechococcus sp. strain PCC7942 required for maximum efficiency of nitrogen assimilation. J Bacteriol. 177:290–296.
   PubMed Web of Science ®Google Scholar
• Sweetlove LJ, Beard KF, Nunes-Nesi A, Fernie AR, Ratcliffe RG. 2010. Not just a circle: flux modes in the plant TCA cycle. Trends Plant Sci. 15:462–470.
   PubMed Web of Science ®Google Scholar
• Takatani N, Kobayashi M, Maeda S-i, Omata T. 2006. Regulation of nitrate reductase by non-modifiable derivatives of PII in the cells of Synechococcus elongatus strain PCC 7942. Plant Cell Physiol. 47:1182–1186.
   PubMed Web of Science ®Google Scholar
• Tamagnini P, Axelsson R, Lindberg P, Oxelfelt F, Wünschiers R, Lindblad P. 2002. Hydrogenases and hydrogen metabolism of cyanobacteria. Microbiol Mol Biol Rev. 66:1–20.
   PubMed Web of Science ®Google Scholar
• Tanigawa R, Shirokane M, Maeda S-i, Omata T, Tanaka K, Takahashi H. 2002. Transcriptional activation of NtcA-dependent promoters of Synechococcus sp. PCC 7942 by 2-oxoglutarate in vitro. PNAS. 99:4251–4255.
   PubMed Web of Science ®Google Scholar
• Thurotte A, Lopez Igual R, Wilson A, Comolet L, Bourcier de Carbon C, Xiao F, Kirilovsky D. 2015. Regulation of orange carotenoid protein activity in cyanobacterial photoprotection. Plant Physiol. 169:737–747.
   PubMed Web of Science ®Google Scholar
• Tian J, Bryk R, Itoh M, Suematsu M, Nathan C. 2005. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of α-ketoglutarate decarboxylase. PNAS. 102:10670–10675.
   PubMed Web of Science ®Google Scholar
• Ting CS, Rocap G, King J, Chisholm SW. 2002. Cyanobacterial photosynthesis in the oceans: the origins and significance of divergent light-harvesting strategies. Trends Microbiol. 10:134–142.
   PubMed Web of Science ®Google Scholar
• Valladares A, Montesinos ML, Herrero A, Flores E. 2002. An ABC-type, high-affinity urea permease identified in cyanobacteria. Mol Microbiol. 43:703–715.
   PubMed Web of Science ®Google Scholar
• van Alphen P, Hellingwerf KJ. 2015. Sustained circadian rhythms in continuous light in Synechocystis sp. PCC6803 growing in a well-controlled photobioreactor. PLoS One. 10:e0127715.
   PubMed Web of Science ®Google Scholar
• van de Meene AML, Hohmann-Marriott MF, Vermaas WFJ, Roberson RW. 2006. The three-dimensional structure of the cyanobacterium Synechocystis sp. PCC 6803. Arch Microbiol. 184:259–270.
   PubMed Web of Science ®Google Scholar
• Vázquez-Bermúdez MaF, Herrero A, Flores E. 2002. 2-Oxoglutarate increases the binding affinity of the NtcA (nitrogen control) transcription factor for the Synechococcus glnA promoter. FEBS Lett. 512:71–74.
   PubMed Web of Science ®Google Scholar
• Vázquez-Bermúdez MF, Herrero A, Flores E. 2000. Uptake of 2-oxoglutarate in Synechococcus strains transformed with the Escherichia coli kgtP gene. J Bacteriol. 182:211–215.
   PubMed Web of Science ®Google Scholar
• Vega-Palas M, Flores E, Herrero A. 1992. NtcA, a global nitrogen regulator from the cyanobacterium Synechococcus that belongs to the Crp family of bacterial regulators. Mol Microbiol. 6:1853–1859.
   PubMed Web of Science ®Google Scholar
• Wang H-L, Postier BL, Burnap RL. 2004. Alterations in global patterns of gene expression in Synechocystis sp. PCC 6803 in response to inorganic carbon limitation and the inactivation of ndhR, a LysR family regulator. J Biol Chem. 279:5739–5751.
   PubMed Web of Science ®Google Scholar
• Wang Y, Xu W, Chitnis PR. 2009. Identification and bioinformatic analysis of the membrane proteins of Synechocystis sp. PCC 6803. Proteome Sci. 7:1–12.
   PubMed Web of Science ®Google Scholar
• Watzer B, Engelbrecht A, Hauf W, Stahl M, Maldener I, Forchhammer K. 2015. Metabolic pathway engineering using the central signal processor P(II). Microb Cell Fact. 14:1–12.
   PubMed Web of Science ®Google Scholar
• Xiong W, Brune D, Vermaas WF. 2014. The γ-aminobutyric acid shunt contributes to closing the tricarboxylic acid cycle in Synechocystis sp. PCC 6803. Mol Microbiol. 93:786–796.
   PubMed Web of Science ®Google Scholar
• Xu K, Jiang H, Juneau P, Qiu B. 2012. Comparative studies on the photosynthetic responses of three freshwater phytoplankton species to temperature and light regimes. J Appl Phycol. 24:1113–1122.
   Web of Science ®Google Scholar
• Xu Y, Carr PD, Clancy P, Garcia-Dominguez M, Forchhammer K, Florencio F, Tandeau de Marsac N, Vasudevan SG, Ollis DL. 2003. The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803. Acta Crystallogr D Biol Crystallogr. 59:2183–2190.
   PubMedGoogle Scholar
• Yang C, Hua Q, Shimizu K. 2002. Metabolic flux analysis in Synechocystis using isotope distribution from 13C-labeled glucose. Metab Eng. 4:202–216.
   PubMed Web of Science ®Google Scholar
• Yang F, Shen G, Schluchter WM, Zybailov B, Ganago A, Golbeck JH, Bryant DA. 1999. Structural and functional analyses of cyanobacterial photosystem I. In: Peschek GA, Löffelhardt W, Schmetterer G, editors. The phototrophic prokaryotes. Boston (MA): Springer; p. 21–33.
   Google Scholar
• Yang Q, Pando BF, Dong G, Golden SS, van Oudenaarden A. 2010. Circadian gating of the cell cycle revealed in single cyanobacterial cells. Science. 327:1522–1526.
   PubMed Web of Science ®Google Scholar
• Yu J, Liberton M, Cliften PF, Head RD, Jacobs JM, Smith RD, Koppenaal DW, Brand JJ, Pakrasi HB. 2015. Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2. Sci Rep. 5:1–10.
   Web of Science ®Google Scholar
• Zalutskaya Z, Kharatyan N, Forchhammer K, Ermilova E. 2015. Reduction of PII signaling protein enhances lipid body production in Chlamydomonas reinhardtii. Plant Sci. 240:1–9.
   PubMed Web of Science ®Google Scholar
• Zeth K, Fokina O, Forchhammer K. 2014. Structural basis and target-specific modulation of ADP sensing by the Synechococcus elongatus P(II) signaling protein. J Biol Chem. 289:8960–8972.
   PubMed Web of Science ®Google Scholar
• Zhang S, Bryant DA. 2011. The tricarboxylic acid cycle in cyanobacteria. Science. 334:1551–1553.
   PubMed Web of Science ®Google Scholar
• Zhang S, Bryant DA. 2015. Biochemical validation of the glyoxylate cycle in the cyanobacterium Chlorogloeopsis fritschii strain PCC 9212. J Biol Chem. 290:14019–14030.
   PubMed Web of Science ®Google Scholar
• Zhang S, Qian X, Chang S, Dismukes GC, Bryant DA. 2016. Natural and synthetic variants of the tricarboxylic acid cycle in cyanobacteria: introduction of the GABA shunt into Synechococcus sp. PCC 7002. Front Microbiol. 7:1–13.
   PubMed Web of Science ®Google Scholar
• Zhao M-X, Jiang Y-L, He Y-X, Chen Y-F, Teng Y-B, Chen Y, Zhang C-C, Zhou C-Z. 2010. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci USA. 107:12487–12492.
   PubMed Web of Science ®Google Scholar