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Review Articles

Antimicrobial resistance: more than 70 years of war between humans and bacteria

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Pages 578-599 | Received 18 Mar 2020, Accepted 18 Aug 2020, Published online: 19 Sep 2020

References

  • Abbassi MS, Torres C, Achour W, Vinué L, Sáenz Y, Costa D, Bouchami O, Ben Hassen A. 2008. Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia. Int J Antimicrob Agents. 32(4):308–314.
  • Abraham EP, Chain E. 1940. An enzyme from bacteria able to destroy penicillin. Nature. 146(3713):837–837.
  • Alanis AJ. 2005. Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res. 36(6):697–705.
  • Amaral L, Martins A, Spengler G, Molnar J. 2014. Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them. Front Pharmacol. 4:168–179.
  • Andersson DI, Hughes D. 2011. Persistence of antibiotic resistance in bacterial populations. FEMS Microbiol Rev. 35(5):901–911.
  • Andersson DI, Hughes D. 2014. Microbiological effects of sublethal levels of antibiotics. Nat Rev Microbiol. 12(7):465–478.
  • Arthur M, Autissier D, Courvalin P. 1986. Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II. Nucleic Acids Res. 14(12):4987–4999.
  • Aslam B, Wang W, Arshad MI, Khurshid M, Muzammil S, Rasool MH, Nisar MA, Alvi RF, Aslam MA, Qamar MU, et al. 2018. Antibiotic resistance: a rundown of a global crisis. Infect Drug Resist. 11:1645–1658.
  • Assefa A, Abunna F. 2018. Maintenance of fish health in aquaculture: review of epidemiological approaches for prevention and control of infectious disease of fish. Vet Med Int. 2018:5432497–5432410.
  • Balcázar JL. 2020. Implications of bacteriophages on the acquisition and spread of antibiotic resistance in the environment. Inter Microbiol. DOI:10.1007/s10123-020-00121-5
  • Balsalobre L, Ferrándiz MJ, Liñares J, Tubau F, de la Campa AG. 2003. Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae. Antimicrob Agents Chemother. 47(7):2072–2081.
  • Bartlett JG, Gilbert DN, Spellberg B. 2013. Seven ways to preserve the miracle of antibiotics. Clin Infect Dis. 56(10):1445–1450. DOI: 56: 1445–1450.
  • Bébéar C, Pereyre S. 2005. Mechanisms of drug resistance in Mycoplasma pneumoniae. Curr Drug Targets Infect Disord. 5(3):263–271.
  • Beceiro A, Tomás M, Bou G. 2013. Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev. 26(2):185–230.
  • Bhullar K, Waglechner N, Pawlowski A, Koteva K, Banks ED, Johnston MD, Barton HA, Wright GD. 2012. Antibiotic resistance is prevalent in an isolated cave microbiome. PloS One. 7(4):e34953.
  • Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ. 2015. Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol. 13(1):42–51.
  • Blanco P, Hernando-Amado S, Reales-Calderon JA, Corona F, Lira F, Alcalde-Rico M, Bernardini A, Sanchez MB, Martinez JL. 2016. Bacterial multidrug efflux pumps: much more than antibiotic resistance determinants. Microorganisms. 4(1):14.
  • Blokesch M. 2016. Natural competence for transformation. Curr Biol. 26(21):R1126–1130.
  • Bonomo RA, Burd EM, Conly J, Limbago BM, Poirel L, Segre JA, Westblade LF. 2018. Carbapenemase-producing organisms: a global scourge. Clin Infect Dis. 66(8):1290–1297.
  • Buckner MM, Ciusa ML, Piddock LJ. 2018. Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing. FEMS Microbiol Rev. 42(6):781–804.
  • Burke V, Richter D, Greskowiak J, Mehrtens A, Schulz L, Massmann G. 2016. Occurrence of antibiotics in surface and groundwater of a drinking water catchment area in Germany. Water Environ Res. 88(7):652–659.
  • Bush K. 2013. Proliferation and significance of clinically relevant β-lactamases. Ann N Y Acad Sci. 1277:84–90.
  • Cabello FC. 2006. Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment. Environ Microbiol. 8(7):1137–1144.
  • Cantas L, Shah SQA, Cavaco LM, Manaia C, Walsh F, Popowska M, Garelick H, Bürgmann H, Sørum H. 2013. A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota. Front Microbiol. 4:96.
  • Carattoli A. 2013. Plasmids and the spread of resistance. Int J Med Microbiol. 303(6-7):298–304.
  • Carratalà J, Garcia-Vidal C. 2010. An update on Legionella. Curr Opin Infect Dis. 23(2):152–157.
  • Cetinkaya Y, Falk P, Mayhall CG. 2000. Vancomycin-Resistant Enterococci. Clin Microbiol Rev. 13(4):686–707.
  • Cheesman MJ, Ilanko A, Blonk B, Cock IE. 2017. Developing new antimicrobial therapies: are synergistic combinations of plant extracts/compounds with conventional antibiotics the solution? Pharmacogn Rev. 11(22):57–72.
  • Chevalier S, Bouffartigues E, Bodilis J, Maillot O, Lesouhaitier O, Feuilloley MG, Orange N, Dufour A, Cornelis P. 2017. Structure, function and regulation of Pseudomonas aeruginosa porins. FEMS Microbiol Rev. 41(5):698–722.
  • Christie PJ. 2016. Classic spotlight: the awesome power of conjugation. J Bacteriol. 198(3):372.
  • Chuah L-O, Effarizah M, Goni AM, Rusul G. 2016. Antibiotic application and emergence of multiple antibiotic resistance (MAR) in global catfish aquaculture. Curr Environ Health Rep. 3(2):118–127.
  • Cižman M, Srovin TP. 2018. Antibiotic consumption and resistance of gram-negative pathogens (collateral damage). GMS Infectious Diseases. 6(9). DOI:10.3205/id000040.
  • Coculescu BI. 2009. Antimicrobial resistance induced by genetic changes. J Med Life. 2(2):114–123.
  • Cohen SN, Chang AC, Hsu L. 1972. Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc Natl Acad Sci USA. 69(8):2110–2114.
  • Cottell JL, Webber MA, Coldham NG, Taylor DL, Cerdeño-Tárraga AM, Hauser H, Thomson NR, Woodward MJ, Piddock LJ. 2011. Complete sequence and molecular epidemiology of IncK epidemic plasmid encoding blaCTX-M-14. Emerging Infect Dis. 17(4):645–652.
  • Cox G, Wright GD. 2013. Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. Int J Med Microbiol. 303(6-7):287–292.
  • Czaplewski L, Bax R, Clokie M, Dawson M, Fairhead H, Fischetti VA, Foster S, Gilmore BF, Hancock REW, Harper D, et al. 2016. Alternatives to antibiotics—a pipeline portfolio review. Lancet Infect Dis. 16(2):239–251.
  • Czekalski N, Díez EG, Bürgmann H. 2014. Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake. Isme J. 8(7):1381–1390.
  • D’Costa VM, Wright GD. 2009. Biochemical logic of antibiotic inactivation and modification. In Mayers DL, Lerner SA, Ouellette M, Sobel JD (eds), Antimicrobial drug resistance, vol 1. New York, NY: Humana Press, p. 81–95.
  • D’Costa VM, King CE, Kalan L, Morar M, Sung WWL, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, et al. 2011. Antibiotic resistance is ancient. Nature. 477(7365):457–461.
  • Datta N, Kontomichalou P. 1965. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature. 208(5007):239–241. London)
  • Davies J, Davies D. 2010. Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev. 74(3):417–433.
  • De Almeida M, Gerard C, Freeman JT, Duffy E, Roberts SA. 2018. Inappropriate prescribing of antibiotics following discharge after major surgery: an area for improvement. N Z Med J. 131(1475):35–43.
  • Dhanda G, Sarkar P, Samaddar S, Haldar J. 2019. Battle against vancomycin-resistant bacteria: recent developments in chemical strategies. J Med Chem. 62(7):3184–3205.
  • do Prado GVB, Marchi AP, Moreno LZ, Rizek C, Amigo U, Moreno AM, Rossi F, Guimaraes T, Levin AS, Costa SF. 2016. Virulence and resistance pattern of a novel sequence type of linezolid-resistant Enterococcus faecium identified by whole-genome sequencing. J Glob Antimicrob Resist. 6:27–31.
  • Dolliver HA, Gupta SC. 2008. Antibiotic losses from unprotected manure stockpiles. J Environ Qual. 37(3):1238–1244.
  • Dwivedi GR, Singh DP, Sharma S, Darokar MP. 2017. Efflux pumps: warheads of gram-negative bacteria and efflux pump inhibitors. In: Sinha RP, Richa, editors. New approaches in biological research. New York: Nova Science Publishers; p. 35–72.
  • ECDC/EMEA 2009. European Centre for Disease Prevention and Control Joint Report with EMEA: The Bacterial I: Time to React. https://ecdc.europa.eu/en/publications-data/ecdcemea-joint-technical-report-bacterial-challenge-time-react. (Accessed on 5 July 2020).
  • Eleraky NE, Allam A, Hassan SB, Omar MM. 2020. Nanomedicine fight against antibacterial resistance: an overview of the recent pharmaceutical innovations. Pharmaceutics. 12(2):142.
  • Fernández L, McPhee JB, Tamber S, Brazas MD, Lewenza S, Hancock RE. 2017. Antibiotic resistance due to reduced uptake. In: Mayers DL, Sobel JD , Ouellette M, Kaye KS, Marchaim D, editors. Antimicrobial Drug Resistance. p.115–130. DOI: 10.1007/978-3-319-46718-4_9.
  • Furlan JPR, Pitondo-Silva A, Stehling EG. 2018. Detection of blaNDM-1 in Stenotrophomonas maltophilia isolated from Brazilian soil. Mem Inst Oswaldo Cruz. 113(6):e170558.
  • Fyfe C, Grossman TH, Kerstein K, Sutcliffe J. 2016. Resistance to macrolide antibiotics in public health pathogens. Cold Spring Harb Perspect Med. 6(10):a025395.
  • Getino M, De la Cruz F. 2019. Natural and artificial strategies to control the conjugative transmission of plasmids. Microbial Spectrum. 6:33–64.
  • Ghafourian S, Sadeghifard N, Soheili S, Sekawi Z. 2015. Extended spectrum beta-lactamases: definition, classification and epidemiology. Curr Issues Mol Biol. 17:11–22.
  • Gillani AH, Ji W, Hussain W, Imran A, Chang J, Yang C, Fang Y. 2017. Antibiotic self-medication among Non-Medical University Students in Punjab, Pakistan: a cross-sectional survey. IJERPH. 14(10):1152.
  • Golkar T, Zieliński M, Berghuis AM. ´ 2018. Look and outlook on enzyme-mediated macrolide resistance. Front Microbiol. 9:1942.
  • Goossens H. 2009. Antibiotic consumption and link to resistance. Clinical Microbiology and Infection. 15:12–15.
  • Graf FE, Palm M, Warringer J, Farewell A. 2019. Inhibiting conjugation as a tool in the fight against antibiotic resistance. Drug Dev Res. 80(1):19–23.
  • Graham DW, Olivares-Rieumont S, Knapp CW, Lima L, Werner D, Bowen E. 2011. Antibiotic resistance gene abundances associated with waste discharges to the Almendares River near Havana, Cuba. Environ Sci Technol. 45(2):418–424.
  • Grenni P, Ancona V, Caracciolo AB. 2018. Ecological effects of antibiotics on natural ecosystems: A review. Microchem J. 136:25–39.
  • Gulkowska A, Leung HW, So MK, Taniyasu S, Yamashita N, Yeung LW, Richardson BJ, Lei A, Giesy JP, Lam PK. 2008. Removal of antibiotics from wastewater by sewage treatment facilities in Hong Kong and Shenzhen, China. Water Res. 42(1-2):395–403.
  • Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D, Andersson DI. 2011. Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog. 7(7):e1002158.
  • Gullberg E, Albrecht LM, Karlsson C, Sandegren L, Andersson DI. 2014. Selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals. MBio. 5(5):e1918–14.
  • Gupta PD, Birdi TJ. 2017. Development of botanicals to combat antibiotic resistance. J Ayurveda Integr Med. 8(4):266–275.
  • Hampton LM, Farley MM, Schaffner W, Thomas A, Reingold A, Harrison LH, Lynfield R, Bennett NM, Petit S, Gershman K, et al. 2012. Prevention of antibiotic-nonsusceptible Streptococcus pneumoniae with conjugate vaccines. J Infect Dis. 205(3):401–411.
  • Hamscher G, Pawelzick HT, Höper H, Nau H. 2005. Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure. Environ Toxicol Chem. 24(4):861–868.
  • Hernando-Amado S, Blanco P, Alcalde-Rico M, Corona F, Reales-Calderón JA, Sánchez MB, Martínez JL. 2016. Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials. Drug Resist Updat. 28:13–27.
  • Hoffman-Roberts HL, C Babcock E, Mitropoulos IF. 2005. Investigational new drugs for the treatment of resistant pneumococcal infections. Expert Opin Investig Drugs. 14(8):973–995.
  • Hughes D, Andersson DI. 2017. Environmental and genetic modulation of the phenotypic expression of antibiotic resistance. FEMS Microbiol Rev. 41(3):374–391.
  • Humeniuk C, Arlet G, Gautier V, Grimont P, Labia R, Philippon A. 2002. Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types . Antimicrob Agents Chemother. 46(9):3045–3049.
  • Jacoby GA. 2006. Beta-lactamase nomenclature. Antimicrob Agents Chemother. 50(4):1123–1129.
  • Karakonstantis S, Kalemaki D. 2019. Antimicrobial overuse and misuse in the community in Greece and link to antimicrobial resistance using methicillin-resistant S. aureus as an example. J Infect Public Health. 12(4):460–464.
  • Kemper N. 2008. Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic. 8(1):1–13.
  • Kim YH, Cerniglia CE. 2005. Influence of erythromycin A on the microbial populations in aquaculture sediment microcosms. Aquat Toxicol. 73(3):230–241.
  • King DT, Sobhanifar S, Strynadka NC. 2016. One ring to rule them all: Current trends in combating bacterial resistance to the β-lactams. Protein Sci. 25(4):787–803.
  • Kollef MH, Fraser VJ. 2001. Antibiotic resistance in the intensive care unit. Ann Intern Med. 134(4):298–314.
  • Krauland M, Harrison L, Paterson D, Marsh J. 2010. Novel integron gene cassette arrays identified in a global collection of multi-drug resistant non-typhoidal Salmonella enterica. Curr Microbiol. 60(3):217–223.
  • Kumar A, Schweizer HP. 2005. Bacterial resistance to antibiotics: active efflux and reduced uptake. Adv Drug Deliv Rev. 57(10):1486–1513.
  • Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, Chaudhary U, Doumith M, Giske CG, Irfan S, et al. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 10(9):597–602.
  • Lakhundi S, Zhang K. 2018. Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology. Clin Microbiol Reviews. 31(4):18.
  • Lambert T. 2012. Antibiotics that affect the ribosome. Rev - off Int Epizoot. 31(1):57–64.
  • Laponogov I, Sohi MK, Veselkov DA, Pan XS, Sawhney R, Thompson AW, McAuley KE, Fisher LM, Sanderson MR. 2009. Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nat Struct Mol Biol. 16(6):667–669.
  • Larsson DJ. 2014. Pollution from drug manufacturing: review and perspectives. Phil Trans R Soc B. 369(1656):20130571.
  • Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, Amicosante G, Fontana R, Rossolini GM. 1999. Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother. 43(7):1584–1590.
  • Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, et al. 2013. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 13(12):1057–1098.
  • Leclercq R, Derlot E, Duval J, Courvalin P. 1988. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med. 319(3):157–161.
  • Lee AS, de Lencastre H, Garau J, Kluytmans J, Malhotra-Kumar S, Peschel A, Harbarth S. 2018. Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 4(1):23.
  • Lerminiaux NA, Cameron AD. 2019. Horizontal transfer of antibiotic resistance genes in clinical environments. Can J Microbiol. 65(1):34–44.
  • Li XZ, Plésiat P, Nikaido H. 2015. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev. 28(2):337–418.
  • Lin YT, Huang YW, Liou RS, Chang YC, Yang TC. 2014. MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation. J Antimicrob Chemother. 69(12):3221–3226.
  • Logan LK, Weinstein RA. 2017. The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace. J Infect Dis. 215(Suppl_1):S28–S36.
  • Lowy FD. 2003. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest. 111(9):1265–1273.
  • Łuczkiewicz A, Jankowska K, Fudala-Książek S, Olańczuk-Neyman K. 2010. Antimicrobial resistance of fecal indicators in municipal wastewater treatment plant. Water Res. 44(17):5089–5097.
  • Lushniak BD. 2014. Antibiotic resistance: a public health crisis. Public Health Rep. 129(4):314–316.
  • Lutgring JD. 2019. Carbapenem-resistant Enterobacteriaceae: an emerging bacterial threat. Semin Diagn Pathol. 36(3):182–186.
  • Luyt C-E, Bréchot N, Trouillet J-L, Chastre J. 2014. Antibiotic stewardship in the intensive care unit. Crit Care. 18(5):480.
  • Machowska A, Stålsby Lundborg C. 2018. Drivers of irrational use of antibiotics in Europe. IJERPH. 16(1):27.
  • Madigan MT, Martinko JM, Bender KS, Buckley DH, Stahl DA. 2015. Brock Biology of Microorganisms. 14/Ed. Glenview, IL: Pearson, p. 302–308.
  • Magiorakos A-P, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, et al. 2012. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance . Clin Microbiol Infect. 18(3):268–281.
  • Maltezou HC, Dedoukou X, Asimaki H, Kontou I, Ioannidou L, Mitromara K, Theodoridou K, Katerelos P, Theodoridou M. 2017. Consumption of antibiotics by children in Greece: a cross-sectional study. Int J Pediatr Adolesc Med. 4(3):108–111.
  • Martinez J, Baquero F. 2000. Mutation frequencies and antibiotic resistance. Antimicrob Agents Chemother. 44(7):1771–1777.
  • Martinez JL. 2014. General principles of antibiotic resistance in bacteria. Drug Discov Today Technol. 11:33–39.
  • Massoudieh A, Mathew A, Lambertini E, Nelson KE, Ginn TR. 2007. Horizontal gene transfer on surfaces in natural porous media: conjugation and kinetics. Vadose Zone J. 6(2):306–325.
  • Matilla MA, Salmond GPC. 2014. Bacteriophage MAM1, a Viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the Enterobacterial genera Serratia and Kluyvera. Appl Environ Microbiol. 80(20):6446–6457. 01546–14.
  • Mazzei T, Mini E, Novelli A, Periti P. 1993. Chemistry and mode of action of macrolides. J Antimicrob Chemother. 31(suppl C):1–9.
  • Mestrovic T, Ljubin-Sternak S. 2018. Molecular mechanisms of Chlamydia trachomatis resistance to antimicrobial drugs. Front Biosci (Landmark Ed)). ) 23:656–670.
  • Michael CA, Dominey-Howes D, Labbate M. 2014. The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health. 2:145–153.
  • Miller WR, Munita JM, Arias CA. 2014. Mechanisms of antibiotic resistance in enterococci. Expert Rev anti Infect Ther. 12(10):1221–1236.
  • Morais C, Jackson JH, Smith AP, Shikotra CV, Maxwell N, Liddington A, Crystal RC. 1997. Crystal structure of the breakage-reunion domain of DNA gyrase. Nature. 388(6645):903–906.
  • Morar M, Bhullar K, Hughes DW, Junop M, Wright GD. 2009. Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. Structure. 17(12):1649–1659.
  • Morar M, Pengelly K, Koteva K, Wright GD. 2012. Mechanism and diversity of the erythromycin esterase family of enzymes. Biochemistry. 51(8):1740–1751.
  • Morita Y, Kimura N, Mima T, Mizushima T, Tsuchiya T. 2001. Roles of MexXY- and MexAB-multidrug efflux pumps in intrinsic multidrug resistance of Pseudomonas aeruginosa PAO1. J Gen Appl Microbiol. 47(1):27–32.
  • Morita Y, Tomida J, Kawamura Y. 2014. Responses of Pseudomonas aeruginosa to antimicrobials. Front Microbiol. 4:422.
  • Munita JM, Arias CA. 2016. Mechanisms of antibiotic resistance. In: Kudva IT, Cornick NA, Plummer PJ, Zhang Q, Nicholson TL, Bannantine JP, Bellaire BH, editors. Microbiology Spectrum. Vol. 4. DOI:10.1128/9781555819286.ch17.
  • Neyfakh AA, Borsch CM, Kaatz GW. 1993. Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrob Agents Chemother. 37(1):128–129.
  • Nikaido H. 1996. Multidrug efflux pumps of gram-negative bacteria. J Bacteriol. 178(20):5853–5859.
  • Nikaido H. 2003. Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev. 67(4):593–656.
  • O'Shea R, Moser HE. 2008. Physicochemical properties of antibacterial compounds: implications for drug discovery. J Med Chem. 51(10):2871–2878.
  • Ochman H, Lawrence JG, Groisman EA. 2000. Lateral gene transfer and the nature of bacterial innovation. Nature. 405(6784):299–304.
  • Oliver A, Cantòn R, Campo P, Baquero F, Blàzquez J. 2000. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science. 288(5469):1251–1254.
  • O'Neill J. 2016. Review on antimicrobial resistance. Tackling drug-resistant infections globally: final report and recommendations. In: Government U, editor. London, UK. https://amr-review.org/Publications.html.
  • Ounissi H, Courvalin P. 1985. Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli. Gene. 35(3):271–278.
  • Pagès J-M, James CE, Winterhalter M. 2008. The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat Rev Microbiol. 6(12):893–903.
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DG. 2015. Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential. BMC Genomics. 16(1):964.
  • Parkinson JS. 2016. Classic spotlight: the discovery of bacterial transduction. J Bacteriol. 198(21):2899–2900.
  • Partridge SR, Kwong SM, Firth N, Jensen SO. 2018. Mobile genetic elements associated with antimicrobial resistance. Clin Microbiol Reviews. 31(4):17.
  • Peterson E, Kaur P. 2018. Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol. 9:2928.
  • Petinaki E, Guérin-Faublée V, Pichereau V, Villers C, Achard A, Malbruny B, Leclercq R. 2008. Lincomycin resistance gene lnu(D) in Streptococcus uberis. Antimicrob Agents Chemother. 52(2):626–630.
  • Piccaro G, Poce G, Biava M, Giannoni F, Fattorini L. 2015. Activity of lipophilic and hydrophilic drugs against dormant and replicating Mycobacterium tuberculosis. J Antibiot. 68(11):711–714.
  • Pitart C, Solé M, Roca I, Fàbrega A, Vila J, Marco F. 2011. First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain . Antimicrob Agents Chemother. 55(9):4398–4401.
  • Pletz MW, McGee L, Van Beneden CA, Petit S, Bardsley M, Barlow M, Klugman KP. 2006. Fluoroquinolone resistance in invasive Streptococcus pyogenes isolates due to spontaneous mutation and horizontal gene transfer. Antimicrob Agents Chemother. 50(3):943–948.
  • Poirel L, Lartigue M-F, Decousser J-W, Nordmann P. 2005. ISEcp1B-mediated transposition of blaCTX-M in Escherichia coli. Antimicrob Agents Chemother. 49(1):447–450.
  • Quan S, Venter H, Dabbs ER. 1997. Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic. Antimicrob Agents Chemother. 41(11):2456–2460.
  • Rafie S, MacDougall C, James CL. 2010. Cethromycin: a promising new ketolide antibiotic for respiratory infections. Pharmacotherapy. 30(3):290–303.
  • Rahman T, Yarnall B, Doyle DA. 2017. Efflux drug transporters at the forefront of antimicrobial resistance. Eur Biophys J. 46(7):647–653.
  • Ramirez MS, Tolmasky ME. 2010. Aminoglycoside modifying enzymes. Drug Resist Updat. 13(6):151–171.
  • Redgrave LS, Sutton SB, Webber MA, Piddock LJ. 2014. Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success. Trends Microbiol. 22(8):438–445.
  • Reygaert W. 2009. Methicillin-resistant Staphylococcus aureus (MRSA): molecular aspects of antimicrobial resistance and virulence. Clin Lab Sci. 22(2):115–119.
  • Reygaert WC. 2018. An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol. 4(3):482–501.
  • Rizzo L, Manaia C, Merlin C, Schwartz T, Dagot C, Ploy M, Michael I, Fatta-Kassinos D. 2013. Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. Sci Total Environ. 447:345–360.
  • Roberts JA, Paul SK, Akova M, Bassetti M, De Waele JJ, Dimopoulos G, Kaukonen K-M, Koulenti D, Martin C, Montravers P, et al.; DALI Study. 2014. DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?. Clinical Infectious Diseases. 58(8):1072–1083.
  • Rodríguez-Rojas A, Rodríguez-Beltrán J, Couce A, Blázquez J. 2013. Antibiotics and antibiotic resistance: a bitter fight against evolution. Int J Med Microbiol. 303(6-7):293–297.
  • Rosenblatt-Farrell N. 2009. The landscape of antibiotic resistance. Environ Health Perspect. 117(6):A244–A250.
  • Sauvage E, Kerff F, Terrak M, Ayala JA, Charlier P. 2008. The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol Rev. 32(2):234–258.
  • Schar D, Sommanustweechai A, Laxminarayan R, Tangcharoensathien V. 2018. Surveillance of antimicrobial consumption in animal production sectors of low-and middle-income countries: Optimizing use and addressing antimicrobial resistance. PLoS Med. 15(3):e1002521.
  • Schindler BD, Kaatz GW. 2016. Multidrug efflux pumps of Gram-positive bacteria. Drug Resist Updat. 27:1–13.
  • Schwarz S, Shen J, Kadlec K, Wang Y, Brenner Michael G, Feßler AT, Vester B. 2016. Lincosamides, streptogramins, phenicols, and pleuromutilins: mode of action and mechanisms of resistance. Cold Spring Harb Perspect Med. 6(11):a027037.
  • Shah NS, Wright A, Bai G-H, Barrera L, Boulahbal F, Martín-Casabona N, Drobniewski F, Gilpin C, Havelková M, Lepe R, et al. 2007. Worldwide emergence of extensively drug-resistant tuberculosis. Emerging Infect Dis. 13(3):380–387.
  • Shaw WV, Packman LC, Burleigh BD, Dell A, Morris HR, Hartley BS. 1979. Primary structure of a chloramphenicol acetyltransferase specified by R plasmids. Nature. 282(5741):870–872.
  • Shriram V, Khare T, Bhagwat R, Shukla R, Kumar V. 2018. Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance. Front Microbiol. 9:2990–3008.
  • Sköld O. 2011. Antibiotics and antibiotic resistance. Hoboken, New Jersey: John Wiley & Sons, Inc. p. 111.
  • Somboro AM, Sekyere JO, Amoako DG, Essack SY, Bester LA. 2018. Diversity and proliferation of metallo-β-lactamases: a clarion call for clinically effective metallo-β-lactamase inhibitors. Appl Environ Microbiol. 84(18):e00698-18.
  • Song M, Liu Y, Huang X, Ding S, Wang Y, Shen J, Zhu K. 2020. A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens. Nat Microbiol. 5(8):1040–1050.
  • Soonthornchaikul N, Garelick H. 2009. Antimicrobial resistance of Campylobacter species isolated from edible bivalve molluscs purchased from Bangkok markets, Thailand. Foodborne Pathog Dis. 6(8):947–951.
  • Spížek J, Řezanka T. 2017. Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications. Biochem Pharmacol. 133:20–28.
  • Spratt BG, Bowler LD, Zhang QY, Zhou J, Smith JM. 1992. Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species. J Mol Evol. 34(2):115–125.
  • Suay-García B, Pérez-Gracia MT. 2019. Present and future of carbapenem-resistant Enterobacteriaceae (CRE) infections. Antibiotics. 8:122.
  • Subirats J, Sànchez-Melsió A, Borrego CM, Balcázar JL, Simonet P. 2016. Metagenomic analysis reveals that bacteriophages are reservoirs of antibiotic resistance genes. Int J Antimicrob Agents. 48(2):163–167.
  • Sultan I, Rahman S, Jan AT, Siddiqui MT, Mondal AH, Haq QMR. 2018. Antibiotics, resistome and resistance mechanisms: a bacterial perspective. Front Microbiol. 9:2066.
  • Sun D. 2018. Pull in and push out: mechanisms of horizontal gene transfer in bacteria. Front Microbiol. 9:2154.
  • Szczepanowski R, Linke B, Krahn I, Gartemann K-H, Gützkow T, Eichler W, Pühler A, Schlüter A. 2009. Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. Microbiology (Reading, Engl).). 155(Pt 7):2306–2319.
  • Tanwar J, Das S, Fatima Z, Hameed S. 2014. Multidrug resistance: an emerging crisis. Interdiscip Perspect Infect Dis. 2014:541340.
  • Thai PK, Ky LX, Binh VN, Nhung PH, Nhan PT, Hieu NQ, Dang NTT, Tam NKB, Anh NTK. 2018. Occurrence of antibiotic residues and antibiotic-resistant bacteria in effluents of pharmaceutical manufacturers and other sources around Hanoi, Vietnam. Sci Total Environ. 645:393–400.
  • Thungapathra M, Amita Sinha KK, Chaudhuri SR, Garg P, Ramamurthy T. 2002. Occurrence of antibiotic resistance gene cassettes aac(6’)-Ib, dfrA5, dfrA12, and ereA2 in Class I Integrons in non-O1,non-O139 Vibrio cholerae strains in India. Antimicrobial Agents Chemotherapy. 46:2948–2955.
  • Tian SF, Chu YZ, Yi Chen B, Nian H, Shang H. 2011. ISEcp1 element in association with bla(CTX-M) genes of E. coli that produce extended-spectrum β-lactamase among the elderly in community settings. Enferm Infecc Microbiol Clin. 29(10):731–734.
  • Tofteland S, Naseer U, Lislevand JH, Sundsfjord A, Samuelsen Ø. 2013. A long-term low-frequency hospital outbreak of KPC-producing Klebsiella pneumoniae involving intergenus plasmid diffusion and a persisting environmental reservoir. PloS One. 8(3):e59015.
  • Torres NF, Chibi B, Middleton LE, Solomon VP, Mashamba-Thompson T. 2018. Evidence of factors influencing self-medication with antibiotics in LMICs: a systematic scoping review protocol. Syst Rev. 7(1):102.
  • Tran NH, Chen H, Reinhard M, Mao F, Gin KY-H. 2016. Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes. Water Res. 104:461–472.
  • Van Boeckel TP, Glennon EE, Chen D, Gilbert M, Robinson TP, Grenfell BT, Levin SA, Bonhoeffer S, Laxminarayan R. 2017. Reducing antimicrobial use in food animals. Science. 357(6358):1350–1352.
  • Vanderhaeghen W, Dewulf J. 2017. Antimicrobial use and resistance in animals and human beings. Lancet Planet Health. 1(8):e307.
  • Vázquez-Laslop N, Mankin AS. 2018. How macrolide antibiotics work. Trends Biochem Sci. 43(9):668–684.
  • Velayati AA, Farnia P, Farahbod AM. 2016. Overview of drug-resistant tuberculosis worldwide. International Journal of Mycobacteriology. 5:S161.
  • Velayati AA, Masjedi MR, Farnia P, Tabarsi P, Ghanavi J, ZiaZarifi AH, Hoffner SE. 2009. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest. 136(2):420–425.
  • Wang G, Wilson TJ, Jiang Q, Taylor DE. 2001. Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori. Antimicrob Agents Chemother. 45(3):727–733.
  • Wang H, Ren L, Yu X, Hu J, Chen Y, He G, Jiang Q. 2017. Antibiotic residues in meat, milk and aquatic products in Shanghai and human exposure assessment. Food Control. 80:217–225.
  • Watanabe M, Iyobe S, Inoue M, Mitsuhashi S. 1991. Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 35(1):147–151.
  • Watts JE, Schreier HJ, Lanska L, Hale MS. 2017. The rising tide of antimicrobial resistance in aquaculture: sources, sinks and solutions. Mar Drugs. 15(6):158.
  • Wellington EMH, Boxall AB, Cross P, Feil EJ, Gaze WH, Hawkey PM, Johnson-Rollings AS, Jones DL, Lee NM, Otten W, et al. 2013. The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria. Lancet Infect Dis. 13(2):155–165.
  • WHO 2015. Global action plan on antimicrobial resistance: Antimicrobial resistance. World Health Organization. Available at: https://www.who.int/antimicrobial-resistance/global-action-plan/en/.
  • WHO 2017. Antibiotic-resistant priority pathogens list: Antimicrobial resistance. World Health Organization. Available at: https://www.who.int/mediacentre/news/releases/2017/Antimicrobial_resistance_VPC_27FEB2017.pdf.
  • Wojkowska-Mach J, Godman B, Glassman A, Kurdi A, Pilc A, Rozanska A, Skoczyński S, Wałaszek M, Bochenek T. 2018. Antibiotic consumption and antimicrobial resistance in Poland; findings and implications. Antimicrob Resist Infect Control. 7(136):1–10.
  • Wright GD. 2005. Bacterial resistance to antibiotics: enzymatic degradation and modification. Adv Drug Deliv Rev. 57(10):1451–1470.
  • Xia Z-J, Wang J, Hu W, Liu H, Gao X-Z, Wu Z-H, Zhang P-Y, Li Y-Z. 2008. Improving conjugation efficacy of Sorangium cellulosum by the addition of dual selection antibiotics. J Ind Microbiol Biotechnol. 35(10):1157–1163.
  • Xing L, Yu H, Qi J, Jiang P, Sun B, Cui J, Ou C, Chang W, Hu Q. 2015. ErmF and ereD Are responsible for erythromycin resistance in riemerella anatipestifer. PLoS One. DOI:10.1371/journal.pone.0131078.
  • Yazawa K, Mikami Y, Maeda A, Akao M, Morisaki N, Iwasaki S. 1993. Inactivation of rifampin by Nocardia brasiliensis. Antimicrob Agents Chemother. 37(6):1313–1317.
  • Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR. 2009. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India . Antimicrob Agents Chemother. 53(12):5046–5054.
  • Zapata-Cachafeiro M, Piñeiro-Lamas M, Guinovart MC, López-Vázquez P, Vázquez-Lago JM, Figueiras A. 2019. Magnitude and determinants of antibiotic dispensing without prescription in Spain: a simulated patient study. J Antimicrob Chemother. 74(2):511–514.
  • Zeman M, Mašlaňová I, Indráková A, Šiborová M, Mikulášek K, Bendíčková K, Plevka P, Vrbovská V, Zdráhal Z, Doškař J, et al. 2017. Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene. Sci Rep. 7:46319
  • Zhang P-Y, Xu P-P, Xia Z-J, Wang J, Xiong J, Li Y-Z. 2013. Combined treatment with the antibiotics kanamycin and streptomycin promotes the conjugation of Escherichia coli. FEMS Microbiol Lett. 348(2):149–156.
  • Zhao F, Liu J, Shi W, Huang F, Liu L, Zhao S, Zhang J. 2019. Antimicrobial susceptibility and genotyping of Mycoplasma pneumoniae isolates in Beijing, China, from 2014 to 2016. Antimicrob Resist Infect Control. 8:18.
  • Zhao X, Ye C, Chang W, Sun S. 2017. Serotype distribution, antimicrobial resistance, and class 1 integrons profiles of Salmonella from animals in slaughterhouses in Shandong Province, China. Front Microbiol. 8:1049.
  • Zilberberg MD, Shorr AF, Micek ST, Vazquez-Guillamet C, Kollef MH. 2014. Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study. Crit Care. 18(6):596.
  • Zuccato E, Calamari D, Natangelo M, Fanelli R. 2000. Presence of therapeutic drugs in the environment. The Lancet. 355(9217):1789–1790.

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