Sneathia: an emerging pathogen in female reproductive disease and adverse perinatal outcomes

References

• Alekshun MN, Levy SB. 2007. Molecular mechanisms of antibacterial multidrug resistance. Cell. 128(6):1037–1050.
   PubMed Web of Science ®Google Scholar
• Anahtar MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M, Padavattan N, Ismail N, Moodley A, Sabatini ME, et al. 2015. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 42(5):965–976.
   PubMed Web of Science ®Google Scholar
• Audirac-Chalifour A, Torres-Poveda K, Bahena-Román M, Téllez-Sosa J, Martínez-Barnetche J, Cortina-Ceballos B, López-Estrada G, Delgado-Romero K, Burguete-García AI, Cantú D, et al. 2016. Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study. PLoS One. 11(4):e0153274.
   PubMed Web of Science ®Google Scholar
• Aujoulat F, Roudière L, Picaud J-C, Jacquot A, Filleron A, Neveu D, Baum T-P, Marchandin H, Jumas-Bilak E. 2014. Temporal dynamics of the very premature infant gut dominant microbiota. BMC Microbiol. 14:325.
   PubMed Web of Science ®Google Scholar
• Bachy B, Bémer P, Tortellier L, Giraudeau C, Reynaud A, Corvec S. 2011. Septic arthritis due to a Sneathia species most closely related to Sneathia sanguinegens. J Med Microbiol. 60(11):1693–1696.
   PubMed Web of Science ®Google Scholar
• Balkus JE, Srinivasan S, Anzala O, Kimani J, Andac C, Schwebke J, Fredricks DN, McClelland RS. 2017. Impact of periodic presumptive treatment for bacterial vaginosis on the vaginal microbiome among women participating in the preventing vaginal infections trial. J Infect Dis. 215(5):723–731.
   PubMed Web of Science ®Google Scholar
• Bennett KW, Eley A. 1993. Fusobacteria: new taxonomy and related diseases. J Med Microbiol. 39(4):246–254.
   PubMed Web of Science ®Google Scholar
• Berman HL, McLaren MR, Callahan BJ. 2020. Understanding and interpreting community sequencing measurements of the vaginal microbiome. BJOG. 127(2):139–146.
   PubMed Web of Science ®Google Scholar
• Blencowe H, Lee ACC, Cousens S, Bahalim A, Narwal R, Zhong N, Chou D, Say L, Modi N, Katz J, et al. 2013. Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010. Pediatr Res. 74(S1):17–34.
   PubMedGoogle Scholar
• Boennelycke M, Christensen JJ, Arpi M, Krause S. 2007. Leptotrichia amnionii found in septic abortion in Denmark. Scand J Infect Dis. 39(4):382–383.
   PubMed Web of Science ®Google Scholar
• Bohlin J, Eldholm V, Pettersson JHO, Brynildsrud O, Snipen L. 2017. The nucleotide composition of microbial genomes indicates differential patterns of selection on core and accessory genomes. BMC Genomics. 18(1):151.
   PubMedGoogle Scholar
• Borgogna JC, Shardell MD, Santori EK, Nelson TM, Rath JM, Glover ED, Ravel J, Gravitt PE, Yeoman CJ, Brotman RM, et al. 2020. The vaginal metabolome and microbiota of cervical HPV-positive and HPV-negative women: a cross-sectional analysis. BJOG. 127(2):182–192.
   PubMed Web of Science ®Google Scholar
• Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, Horvath LB, Kuzevska I, Fairley CK. 2006. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis. 193(11):1478–1486.
   PubMed Web of Science ®Google Scholar
• Brotman RM, Bradford LL, Conrad M, Gajer P, Ault K, Peralta L, Forney LJ, Carlton JM, Abdo Z, Ravel J, et al. 2012. Association between Trichomonas vaginalis and vaginal bacterial community composition among reproductive-age women. Sex Transm Dis. 39(10):807–812.
   PubMed Web of Science ®Google Scholar
• Brown RG, Marchesi JR, Lee YS, Smith A, Lehne B, Kindinger LM, Terzidou V, Holmes E, Nicholson JK, Bennett PR, et al. 2018. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. BMC Med. 16(1):9.
   PubMed Web of Science ®Google Scholar
• Burnham P, Gomez-Lopez N, Heyang M, Cheng AP, Lenz JS, Dadhania DM, Lee JR, Suthanthiran M, Romero R, De Vlaminck I, et al. 2020. Separating the signal from the noise in metagenomic cell-free DNA sequencing. Microbiome. 8(1):18.
   PubMed Web of Science ®Google Scholar
• Carlstein C, Soes LM, Jorgen Christensen J. 2016. Aerococcus christensenii as part of severe polymicrobial chorioamnionitis in a pregnant woman. Open Microbiol J. 10:27–31.
   PubMedGoogle Scholar
• Casey BM, Cox SM. 1997. Chorioamnionitis and endometritis. Infect Dis Clin North Am. 11(1):203–222.
   PubMed Web of Science ®Google Scholar
• Castro J, Jefferson KK, Cerca N. 2018. Innate immune components affect growth and virulence traits of bacterial-vaginosis-associated and non-bacterial-vaginosis-associated Gardnerella vaginalis strains similarly. Pathog Dis. 76(9):1–7.
   Web of Science ®Google Scholar
• Chaiyasit N, Romero R, Chaemsaithong P, Docheva N, Bhatti G, Kusanovic JP, Dong Z, Yeo L, Pacora P, Hassan SS, et al. 2017. Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation. J Perinat Med. 45(5):539–550.
   PubMed Web of Science ®Google Scholar
• Chawanpaiboon S, Vogel JP, Moller A-B, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, et al. 2019. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 7(1):e37–e46.
   PubMed Web of Science ®Google Scholar
• Chen Y, Hong Z, Wang W, Gu L, Gao H, Qiu L, Di W. 2019. Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women. BMC Infect Dis. 19(1):677.
   PubMedGoogle Scholar
• Cohen PA, Jhingran A, Oaknin A, Denny L. 2019. Cervical cancer. Lancet. 393(10167):169–182.
   PubMed Web of Science ®Google Scholar
• Collins MD, Hoyles L, Tornqvist E, von Essen R, Falsen E. 2001. Characterization of some strains from human clinical sources which resemble “Leptotrichia sanguinegens”: description of Sneathia sanguinegens sp. nov., gen. nov. Syst Appl Microbiol. 24(3):358–361.
   PubMed Web of Science ®Google Scholar
• Costerton JW, Stewart PS, Greenberg EP. 1999. Bacterial biofilms: a common cause of persistent infections. Science. 284(5418):1318–1322.
   PubMed Web of Science ®Google Scholar
• Cruciani F, Biagi E, Severgnini M, Consolandi C, Calanni F, Donders G, Brigidi P, Vitali B. 2015. Development of a microarray-based tool to characterize vaginal bacterial fluctuations and application to a novel antibiotic treatment for bacterial vaginosis. Antimicrob Agents Chemother. 59(5):2825–2834.
   PubMed Web of Science ®Google Scholar
• De Martino SJ, Mahoudeau I, Brettes JP, Piemont Y, Monteil H, Jaulhac B. 2004. Peripartum bacteremias due to Leptotrichia amnionii and Sneathia sanguinegens, rare causes of fever during and after delivery. J Clin Microbiol. 42(12):5940–5943.
   PubMed Web of Science ®Google Scholar
• Di Paola M, Sani C, Clemente AM, Iossa A, Perissi E, Castronovo G, Tanturli M, Rivero D, Cozzolino F, Cavalieri D, et al. 2017. Characterization of cervico-vaginal microbiota in women developing persistent high-risk Human Papillomavirus infection. Sci Rep. 7(1):10200.
   PubMedGoogle Scholar
• Di Quinzio MKW, Oliva K, Holdsworth SJ, Ayhan M, Walker SP, Rice GE, Georgiou HM, Permezel M. 2007. Proteomic analysis and characterisation of human cervico-vaginal fluid proteins. Aust N Z J Obstet Gynaecol. 47(1):9–15.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC. 2009. The great obstetrical syndromes. J Matern Fetal Neonatal Med. 22(8):633–635.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Roura LC, Facchinetti F, Antsaklis A, Breborowicz G, Gratacos E, Husslein P, Lamont R, Mikhailov A, Montenegro N, et al. 2011. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 24(5):659–667.
   PubMed Web of Science ®Google Scholar
• DiGiulio DB, Romero R, Kusanovic JP, Gomez R, Kim CJ, Seok KS, Gotsch F, Mazaki-Tovio S, Vaisbuch E, Sanders K, et al. 2010. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol. 64(1):38–57.
   PubMed Web of Science ®Google Scholar
• DiGiulio DB, Gervasi M, Romero R, Mazaki-Tovi S, Vaisbuch E, Kusanovic JP, Seok KS, Gómez R, Mittal P, Gotsch F, et al. 2010. Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods. J Perinat Med. 38(5):503–513.
   PubMed Web of Science ®Google Scholar
• DiGiulio DB, Gervasi MT, Romero R, Vaisbuch E, Mazaki-Tovi S, Kusanovic JP, Seok KS, Gómez R, Mittal P, Gotsch F, et al. 2010. Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses. J Perinat Med. 38(5):495–502.
   PubMed Web of Science ®Google Scholar
• DiGiulio DB, Romero R, Amogan HP, Kusanovic JP, Bik EM, Gotsch F, Kim CJ, Erez O, Edwin S, Relman DA, et al. 2008. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One. 3(8):e3056.
   PubMed Web of Science ®Google Scholar
• Dols JA, Smit PW, Kort R, Reid G, Schuren FHJ, Tempelman H, Bontekoe TR, Korporaal H. 2011. Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis. Am J Obstet Gynecol. 204(4):305 e1–7.
   PubMed Web of Science ®Google Scholar
• Dols JAM, Molenaar D, van der Helm JJ, Caspers MPM, de Kat Angelino-Bart A, Schuren FHJ, Speksnijder AGCL, Westerhoff HV, Richardus JH, Boon ME, et al. 2016. Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity. BMC Infect Dis. 16:180.
   PubMed Web of Science ®Google Scholar
• Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. 2010. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 107(26):11971–11975.
   PubMed Web of Science ®Google Scholar
• Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I. 2015. Human papillomavirus molecular biology and disease association. Rev Med Virol. 25(1):2–23.
   PubMedGoogle Scholar
• Duff P. 1997. Antibiotic selection in obstetric patients. Infect Dis Clin North Am. 11(1):1–12.
   PubMed Web of Science ®Google Scholar
• Egawa N, Egawa K, Griffin H, Doorbar J. 2015. Human papillomaviruses; epithelial tropisms, and the development of neoplasia. Viruses. 7(7):3863–3890.
   PubMed Web of Science ®Google Scholar
• Eisenberg T, Fawzy A, Nicklas W, Semmler T, Ewers C. 2016. Phylogenetic and comparative genomics of the family Leptotrichiaceae and introduction of a novel fingerprinting MLVA for Streptobacillus moniliformis. BMC Genomics. 17(1):864.
   PubMedGoogle Scholar
• Elovitz MA, Gajer P, Riis V, Brown AG, Humphrys MS, Holm JB, Ravel J. 2019. Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery. Nat Commun. 10(1):1305.
   PubMedGoogle Scholar
• Eribe ER, Olsen I. 2008. Leptotrichia species in human infections. Anaerobe. 14(3):131–137.
   PubMed Web of Science ®Google Scholar
• Eribe ERK, Olsen I. 2017. Leptotrichia species in human infections II. J Oral Microbiol. 9(1):1368848.
   PubMed Web of Science ®Google Scholar
• Eribe ERK, Paster BJ, Caugant DA, Dewhirst FE, Stromberg VK, Lacy GH, Olsen I. 2004. Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 54(2):583–592.
   PubMedGoogle Scholar
• Faro S, Walker C, Pierson RL. 1980. Amnionitis with intact amniotic membranes involving Streptobacillus moniliformis. Obstet Gynecol. 55(3):9S–11S.
   PubMedGoogle Scholar
• Fethers K, Twin J, Fairley CK, Fowkes FJI, Garland SM, Fehler G, Morton AM, Hocking JS, Tabrizi SN, Bradshaw CS, et al. 2012. Bacterial vaginosis (BV) candidate bacteria: associations with BV and behavioural practices in sexually-experienced and inexperienced women. PLoS One. 7(2):e30633.
   PubMed Web of Science ®Google Scholar
• Fettweis JM, Serrano MG, Brooks JP, Edwards DJ, Girerd PH, Parikh HI, Huang B, Arodz TJ, Edupuganti L, Glascock AL, et al. 2019. The vaginal microbiome and preterm birth. Nat Med. 25(6):1012–1021.
   PubMed Web of Science ®Google Scholar
• Florova V, Romero R, Tarca AL, Galaz J, Motomura K, Ahmad MM, Hsu C-D, Hsu R, Tong A, Ravel J, et al. 2021. Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term. Cytokine. 137:155316.
   PubMed Web of Science ®Google Scholar
• Fredricks DN, Fiedler TL, Marrazzo JM. 2005. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med. 353(18):1899–1911.
   PubMed Web of Science ®Google Scholar
• Fredricks DN, Fiedler TL, Thomas KK, Mitchell CM, Marrazzo JM. 2009. Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol. 47(3):721–726.
   PubMed Web of Science ®Google Scholar
• Frost LS, Leplae R, Summers AO, Toussaint A. 2005. Mobile genetic elements: the agents of open source evolution. Nat Rev Microbiol. 3(9):722–732.
   PubMed Web of Science ®Google Scholar
• Gaastra W, Boot R, Ho HTK, Lipman LJA. 2009. Rat bite fever. Vet Microbiol. 133(3):211–228.
   PubMed Web of Science ®Google Scholar
• Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte UME, Zhong X, Koenig SSK, Fu L, Ma ZS, Zhou X, et al. 2012. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 4(132):132ra52.
   PubMed Web of Science ®Google Scholar
• Galaz J, Romero R, Slutsky R, Xu Y, Motomura K, Para R, Pacora P, Panaitescu B, Hsu C-D, Kacerovsky M, et al. 2020. Cellular immune responses in amniotic fluid of women with preterm prelabour rupture of membranes. J Perinat Med. 48(3):222–233.
   PubMed Web of Science ®Google Scholar
• Galaz J, Romero R, Xu Y, Miller D, Slutsky R, Levenson D, Hsu C-D, Gomez-Lopez N. 2020. Cellular immune responses in amniotic fluid of women with preterm clinical chorioamnionitis. Inflamm Res. 69(2):203–216.
   PubMed Web of Science ®Google Scholar
• Garcia EM, Kraskauskiene V, Koblinski JE, Jefferson KK. 2019. Interaction of Gardnerella vaginalis and Vaginolysin with the Apical versus Basolateral Face of a Three-Dimensional Model of Vaginal Epithelium. Infect Immun. 87(4):1–16.
   Web of Science ®Google Scholar
• Gardella C, Riley DE, Hitti J, Agnew K, Krieger JN, Eschenbach D. 2004. Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol. 21(6):319–323.
   PubMed Web of Science ®Google Scholar
• Gentile GL, Rupert AS, Carrasco LI, Garcia EM, Kumar NG, Walsh SW, Jefferson KK. 2020. Identification of a cytopathogenic toxin from Sneathia amnii. J Bacteriol. 202(13):1–11.
   Web of Science ®Google Scholar
• Gibbs RS, Blanco JD, St Clair PJ, Castaneda YS. 1982. Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. J Infect Dis. 145(1):1–8.
   PubMed Web of Science ®Google Scholar
• Gibbs RS, Dinsmoor MJ, Newton ER, Ramamurthy RS. 1988. A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection. Obstet Gynecol. 72(6):823–828.
   PubMed Web of Science ®Google Scholar
• Gibbs RS, Duff P. 1991. Progress in pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol. 164(5):1317–1326.
   PubMed Web of Science ®Google Scholar
• Gilstrap LC, 3rd, Cox SM. 1989. Acute chorioamnionitis. Obstet Gynecol Clin North Am. 16(2):373–379.
   PubMed Web of Science ®Google Scholar
• Goldenberg RL, Culhane JF, Iams JD, Romero R. 2008. Epidemiology and causes of preterm birth. Lancet. 371(9606):75–84.
   PubMed Web of Science ®Google Scholar
• Goldenberg RL, Thom E, Moawad AH, Johnson F, Roberts J, Caritis SN. 1996. The preterm prediction study: fetal fibronectin, bacterial vaginosis, and peripartum infection. NICHD Maternal Fetal Medicine Units Network. Obstet Gynecol. 87(5):656–660.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Galaz J, Xu Y, Panaitescu B, Slutsky R, Motomura K, Gill N, Para R, Pacora P, et al. 2019. Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation. Am J Reprod Immunol. 82(5):e13171.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Garcia-Flores V, Xu Y, Leng Y, Alhousseini A, Hassan SS, Panaitescu B. 2017. Amniotic fluid neutrophils can phagocytize bacteria: a mechanism for microbial killing in the amniotic cavity. Am J Reprod Immunol. 78(4):e12723.
   Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Leng Y, Xu Y, Slutsky R, Levenson D, Pacora P, Jung E, Panaitescu B, Hsu C-D, et al. 2019. The origin of amniotic fluid monocytes/macrophages in women with intra-amniotic inflammation or infection. J Perinat Med. 47(8):822–840.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, Pacora P, Tarca AL, Motomura K, Erez O, et al. 2019. Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. J Perinat Med. 47(3):276–287.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Xu Y, Leng Y, Garcia-Flores V, Miller D, Jacques SM, Hassan SS, Faro J, Alsamsam A, et al. 2017. Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin? Am J Obstet Gynecol. 217(6):693.e1–693.e16.
   Web of Science ®Google Scholar
• Goncalves LF, Chaiworapongsa T, Romero R. 2002. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev. 8(1):3–13.
   PubMedGoogle Scholar
• Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, et al. 2017. Lactobacillus-deficient cervicovaginal bacterial communities are associated with increased HIV acquisition in young South African women. Immunity. 46(1):29–37.
   PubMed Web of Science ®Google Scholar
• Gotsch F, Romero R, Kusanovic JP, Mazaki-Tovi S, Pineles BL, Erez O, Espinoza J, Hassan SS. 2007. The fetal inflammatory response syndrome. Clin Obstet Gynecol. 50(3):652–683.
   PubMed Web of Science ®Google Scholar
• Gottschick C, Deng Z-L, Vital M, Masur C, Abels C, Pieper DH, Rohde M, Mendling W, Wagner-Döbler I. 2017. Treatment of biofilms in bacterial vaginosis by an amphoteric tenside pessary-clinical study and microbiota analysis. Microbiome. 5(1):119.
   PubMedGoogle Scholar
• Gottschick C, Deng Z-L, Vital M, Masur C, Abels C, Pieper DH, Wagner-Döbler I. 2017. The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment. Microbiome. 5(1):99.
   PubMedGoogle Scholar
• Gundi VA, Desbriere R, Scola BL. 2004. Leptotrichia amnionii and the female reproductive tract. Emerg Infect Dis. 10(11):2056–2057.
   PubMed Web of Science ®Google Scholar
• Gupta RS, Sethi M. 2014. Phylogeny and molecular signatures for the phylum Fusobacteria and its distinct subclades. Anaerobe. 28:182–198.
   PubMed Web of Science ®Google Scholar
• Haggerty CL, Hillier SL, Bass DC, Ness RB. 2004. Bacterial vaginosis and anaerobic bacteria are associated with endometritis. Clin Infect Dis. 39(7):990–995.
   PubMed Web of Science ®Google Scholar
• Haggerty CL, Totten PA, Ferris M, Martin DH, Hoferka S, Astete SG, Ondondo R, Norori J, Ness RB. 2009. Clinical characteristics of bacterial vaginosis among women testing positive for fastidious bacteria. Sex Transm Infect. 85(4):242–248.
   PubMed Web of Science ®Google Scholar
• Hanff PA, Rosol-Donoghue JA, Spiegel CA, Wilson KH, Moore LH. 1995. Leptotrichia sanguinegens sp. nov., a new agent of postpartum and neonatal bacteremia. Clin Infect Dis. 20(2):S237–S239.
   PubMedGoogle Scholar
• Hardy L, Cerca N, Jespers V, Vaneechoutte M, Crucitti T. 2017. Bacterial biofilms in the vagina. Res Microbiol. 168(9-10):865–874.
   PubMed Web of Science ®Google Scholar
• Hardy L, Jespers V, Abdellati S, De Baetselier I, Mwambarangwe L, Musengamana V, van de Wijgert J, Vaneechoutte M, Crucitti T. 2016. A fruitful alliance: the synergy between Atopobium vaginae and Gardnerella vaginalis in bacterial vaginosis-associated biofilm. Sex Transm Infect. 92(7):487–491.
   PubMed Web of Science ®Google Scholar
• Harmanli OH, Cheng GY, Nyirjesy P, Chatwani A, Gaughan JP. 2000. Urinary tract infections in women with bacterial vaginosis. Obstet Gynecol. 95(5):710–712.
   PubMed Web of Science ®Google Scholar
• Harwich MD, Alves JM, Buck GA, Strauss JF, Patterson JL, Oki AT, Girerd PH, Jefferson KK. Jr., 2010. Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies. BMC Genomics. 11:375.
   PubMed Web of Science ®Google Scholar
• Harwich MD, Serrano MG, Fettweis JM, Alves JMP, Reimers MA, Buck GA, Jefferson KK. Jr. 2012. Genomic sequence analysis and characterization of Sneathia amnii sp. nov. BMC Genomics. 13(8):S4.
   PubMedGoogle Scholar
• Hilbert DW, Smith WL, Paulish-Miller TE, Chadwick SG, Toner G, Mordechai E, Adelson ME, Sobel JD, Gygax SE. 2016. Utilization of molecular methods to identify prognostic markers for recurrent bacterial vaginosis. Diagn Microbiol Infect Dis. 86(2):231–242.
   PubMed Web of Science ®Google Scholar
• Hildebrand F, Meyer A, Eyre-Walker A. 2010. Evidence of selection upon genomic GC-content in bacteria. PLoS Genet. 6(9):e1001107.
   PubMed Web of Science ®Google Scholar
• Hillier SL, Kiviat NB, Hawes SE, Hasselquist MB, Hanssen PW, Eschenbach DA, Holmes KK. 1996. Role of bacterial vaginosis-associated microorganisms in endometritis. Am J Obstet Gynecol. 175(2):435–441.
   PubMed Web of Science ®Google Scholar
• Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin DH, Cotch MF, Edelman R, Pastorek JG, Rao AV, et al. 1995. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med. 333(26):1737–1742.
   PubMed Web of Science ®Google Scholar
• Hocevar K, Maver A, Simic MV, Hodzic A, Haslberger A, Sersen TP, Peterlin B. 2019. Vaginal microbiome signature is associated with spontaneous preterm delivery. Front Med (Lausanne). 6:201.
   PubMed Web of Science ®Google Scholar
• Hornychova H, Kacerovsky M, Musilova I, Pliskova L, Zemlickova H, Matejkova A, Vosmikova H, Rozkosova K, Cermakova P, Bolehovska R, et al. 2018. Cervical human papillomavirus infection in women with preterm prelabour rupture of membranes. PLoS One. 13(11):e0207896.
   PubMed Web of Science ®Google Scholar
• Jung H-S, Ehlers MM, Lombaard H, Redelinghuys MJ, Kock MM. 2017. Etiology of bacterial vaginosis and polymicrobial biofilm formation. Crit Rev Microbiol. 43(6):651–667.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Celec P, Vlkova B, Skogstrand K, Hougaard DM, Cobo T, Jacobsson B. 2013. Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria. PLoS One. 8(3):e60399.
   PubMed Web of Science ®Google Scholar
• Kenyon C, Colebunders R, Crucitti T. 2013. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 209(6):505–523.
   PubMed Web of Science ®Google Scholar
• Kotaskova I, Nemec P, Vanerkova M, Malisova B, Tejkalova R, Orban M, Zampachova V, Freiberger T. 2017. First report of Sneathia sanguinegens together with Mycoplasma hominis in postpartum prosthetic valve infective endocarditis: a case report. BMC Infect Dis. 17(1):563.
   PubMedGoogle Scholar
• Koumans EH, Sternberg M, Bruce C, McQuillan G, Kendrick J, Sutton M, Markowitz LE. 2007. The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis. 34(11):864–869.
   PubMed Web of Science ®Google Scholar
• Kulkarni P, Frommolt P. 2017. Challenges in the setup of large-scale next-generation sequencing analysis workflows. Comput Struct Biotechnol J. 15:471–477.
   PubMed Web of Science ®Google Scholar
• Kurjak A, Renzo GCD, Stanojevic M. 2010. Globalization and perinatal medicine–how do we respond? J Matern Fetal Neonatal Med. 23(4):286–296.
   PubMed Web of Science ®Google Scholar
• Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ. 2017. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr. 171(4):365–371.
   PubMed Web of Science ®Google Scholar
• Lamp KC, Freesman CD, Klutman NE, Lacy MK. 1999. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Clin Pharmacokinet. 36(5):353–373.
   PubMed Web of Science ®Google Scholar
• Laniewski P, Barnes D, Goulder A, Cui H, Roe DJ, Chase DM, Herbst-Kralovetz MM. 2018. Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women. Sci Rep. 8(1):7593.
   PubMedGoogle Scholar
• Lannon SMR, Adams Waldorf KM, Fiedler T, Kapur RP, Agnew K, Rajagopal L, Gravett MG, Fredricks DN. 2019. Parallel detection of lactobacillus and bacterial vaginosis-associated bacterial DNA in the chorioamnion and vagina of pregnant women at term. J Matern Fetal Neonatal Med. 32(16):2702–2710.
   PubMed Web of Science ®Google Scholar
• Lee AC, Blencowe H, Lawn JE. 2019. Small babies, big numbers: global estimates of preterm birth. Lancet Glob Health. 7(1):e2–e3.
   PubMed Web of Science ®Google Scholar
• Lee JE, Lee S, Lee H, Song Y-M, Lee K, Han MJ, Sung J, Ko GPyo. 2013. Association of the vaginal microbiota with human papillomavirus infection in a Korean twin cohort. PLoS One. 8(5):e63514.
   PubMed Web of Science ®Google Scholar
• Lee SE, Romero R, Jung H, Park C-W, Park JS, Yoon BH. 2007. The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity. Am J Obstet Gynecol. 197(3):294.
   PubMed Web of Science ®Google Scholar
• Lee SE, Romero R, Kim CJ, Shim S-S, Yoon BH. 2006. Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. J Matern Fetal Neonatal Med. 19(11):693–697.
   PubMed Web of Science ®Google Scholar
• Leitich H, Bodner-Adler B, Brunbauer M, Kaider A, Egarter C, Husslein P. 2003. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol. 189(1):139–147.
   PubMed Web of Science ®Google Scholar
• Ling Z, Liu X, Chen W, Luo Y, Yuan L, Xia Y, Nelson KE, Huang S, Zhang S, Wang Y, et al. 2013. The restoration of the vaginal microbiota after treatment for bacterial vaginosis with metronidazole or probiotics. Microb Ecol. 65(3):773–780.
   PubMed Web of Science ®Google Scholar
• Ling Z, Liu X, Chen X, Zhu H, Nelson KE, Xia Y, Li L, Xiang C. 2011. Diversity of cervicovaginal microbiota associated with female lower genital tract infections. Microb Ecol. 61(3):704–714.
   PubMed Web of Science ®Google Scholar
• Liu CM, Hungate BA, Tobian AAR, Ravel J, Prodger JL, Serwadda D, Kigozi G, Galiwango RM, Nalugoda F, Keim P, et al. 2015. Penile microbiota and female partner bacterial vaginosis in Rakai, Uganda. mBio. 6(3):e00589.
   PubMed Web of Science ®Google Scholar
• Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, Cousens S, Mathers C, Black RE. 2015. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 385(9966):430–440.
   PubMed Web of Science ®Google Scholar
• Lofmark S, Edlund C, Nord CE. 2010. Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis. 50(1):S16–S23.
   PubMedGoogle Scholar
• Ma B, France MT, Crabtree J, Holm JB, Humphrys MS, Brotman RM, Ravel J. 2020. A comprehensive non-redundant gene catalog reveals extensive within-community intraspecies diversity in the human vagina. Nat Commun. 11(1):940.
   PubMed Web of Science ®Google Scholar
• Macklaim JM, Clemente JC, Knight R, Gloor GB, Reid G. 2015. Changes in vaginal microbiota following antimicrobial and probiotic therapy. Microb Ecol Health Dis. 26:27799.
   PubMedGoogle Scholar
• Marconi C, de Andrade Ramos BR, Peraçoli JC, Donders GGG, da Silva MG. 2011. Amniotic fluid interleukin-1 beta and interleukin-6, but not interleukin-8 correlate with microbial invasion of the amniotic cavity in preterm labor. Am J Reprod Immunol. 65(6):549–556.
   PubMed Web of Science ®Google Scholar
• Marconi C, Donders GG, Parada CMGL, Giraldo PC, da Silva MG. 2013. Do Atopobium vaginae, Megasphaera sp. and Leptotrichia sp. change the local innate immune response and sialidase activity in bacterial vaginosis? Sex Transm Infect. 89(2):167–173.
   PubMed Web of Science ®Google Scholar
• Marrazzo JM, Fiedler TL, Srinivasan S, Thomas KK, Liu C, Ko D, Xie H, Saracino M, Fredricks DN. 2012. Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis. J Infect Dis. 205(10):1580–1588.
   PubMed Web of Science ®Google Scholar
• Martinez-Varea A, Romero R, Xu Y, Miller D, Ahmed AI, Chaemsaithong P, Chaiyasit N, Yeo L, Shaman M, Lannaman K, et al. 2017. Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response. J Perinat Med. 45(5):523–538.
   PubMed Web of Science ®Google Scholar
• McClelland RS, Lingappa JR, Srinivasan S, Kinuthia J, John-Stewart GC, Jaoko W, Richardson BA, Yuhas K, Fiedler TL, Mandaliya KN, et al. 2018. Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: a nested case-control study. Lancet Infect Dis. 18(5):554–564.
   PubMed Web of Science ®Google Scholar
• Mehta SD, Zhao D, Green SJ, Agingu W, Otieno F, Bhaumik R, Bhaumik D, Bailey RC. 2020. The microbiome composition of a man’s penis predicts incident bacterial vaginosis in his female sex partner with high accuracy. Front Cell Infect Microbiol. 10:433.
   PubMed Web of Science ®Google Scholar
• Mirmonsef P, Hotton AL, Gilbert D, Gioia CJ, Maric D, Hope TJ, Landay AL, Spear GT. 2016. Glycogen levels in undiluted genital fluid and their relationship to vaginal pH, estrogen, and progesterone. PLoS One. 11(4):e0153553.
   PubMed Web of Science ®Google Scholar
• Mitchell C, Fredricks D, Agnew K, Hitti J. 2015. Hydrogen peroxide-producing Lactobacilli are associated with lower levels of vaginal interleukin-1β, independent of bacterial vaginosis. Sex Transm Dis. 42(7):358–363.
   PubMed Web of Science ®Google Scholar
• Mitchell CM, Hitti JE, Agnew KJ, Fredricks DN. 2009. Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria. BMC Infect Dis. 9:89.
   PubMed Web of Science ®Google Scholar
• Mitra A, MacIntyre DA, Lee YS, Smith A, Marchesi JR, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Li JV, et al. 2015. Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity. Sci Rep. 5(1):16865.
   PubMedGoogle Scholar
• Moon J-Y, Zolnik CP, Wang Z, Qiu Y, Usyk M, Wang T, Kizer JR, Landay AL, Kurland IJ, Anastos K, et al. 2018. Gut microbiota and plasma metabolites associated with diabetes in women with, or at high risk for, HIV infection. EBioMedicine. 37:392–400.
   PubMed Web of Science ®Google Scholar
• Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJF, Meijer CJLM. 2003. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 348(6):518–527.
   PubMed Web of Science ®Google Scholar
• Murphy K, Mitchell CM. 2016. The interplay of host immunity, environment and the risk of bacterial vaginosis and associated reproductive health outcomes. J Infect Dis. 214(1):S29–S35.
   PubMedGoogle Scholar
• Musilova I, Andrys C, Drahosova M, Zednikova B, Hornychova H, Pliskova L, Zemlickova H, Jacobsson B, Kacerovsky M. 2018. Late preterm prelabour rupture of fetal membranes: fetal inflammatory response and neonatal outcome. Pediatr Res. 83(3):630–637.
   PubMed Web of Science ®Google Scholar
• Musilova I, Kacerovsky M, Stepan M, Bestvina T, Pliskova L, Zednikova B, Jacobsson B. 2017. Maternal serum C-reactive protein concentration and intra-amniotic inflammation in women with preterm prelabour rupture of membranes. PLoS One. 12(8):e0182731.
   PubMed Web of Science ®Google Scholar
• Musilova I, Pliskova L, Gerychova R, Janku P, Simetka O, Matlak P, Jacobsson B, Kacerovsky M. 2017. Maternal white blood cell count cannot identify the presence of microbial invasion of the amniotic cavity or intra-amniotic inflammation in women with preterm prelabour rupture of membranes. PLoS One. 12(12):e0189394.
   PubMed Web of Science ®Google Scholar
• Muzny CA, Blanchard E, Taylor CM, Aaron KJ, Talluri R, Griswold ME, Redden DT, Luo M, Welsh DA, Van Der Pol WJ, et al. 2018. Identification of key bacteria involved in the induction of incident bacterial vaginosis: a prospective study. J Infect Dis. 218(6):966–978.
   PubMed Web of Science ®Google Scholar
• Nasioudis D, Linhares IM, Ledger WJ, Witkin SS. 2017. Bacterial vaginosis: a critical analysis of current knowledge. BJOG. 124(1):61–69.
   PubMed Web of Science ®Google Scholar
• Nelson DB, Hanlon A, Nachamkin I, Haggerty C, Mastrogiannis DS, Liu C, Fredricks DN. 2014. Early pregnancy changes in bacterial vaginosis-associated bacteria and preterm delivery. Paediatr Perinat Epidemiol. 28(2):88–96.
   PubMed Web of Science ®Google Scholar
• Nelson DE, Van Der Pol B, Dong Q, Revanna KV, Fan B, Easwaran S, Sodergren E, Weinstock GM, Diao L, Fortenberry JD, et al. 2010. Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection. PLoS One. 5(11):e14116.
   PubMed Web of Science ®Google Scholar
• Nelson TM, Borgogna J-LC, Brotman RM, Ravel J, Walk ST, Yeoman CJ. 2015. Vaginal biogenic amines: biomarkers of bacterial vaginosis or precursors to vaginal dysbiosis? Front Physiol. 6:253.
   PubMed Web of Science ®Google Scholar
• Newton ER. 1993. Chorioamnionitis and intraamniotic infection. Clin Obstet Gynecol. 36(4):795–808.
   PubMed Web of Science ®Google Scholar
• Niu SY, Yang J, McDermaid A, Zhao J, Kang Y, Ma Q. 2018. Bioinformatics tools for quantitative and functional metagenome and metatranscriptome data analysis in microbes. Brief Bioinform. 19(6):1415–1429.
   PubMed Web of Science ®Google Scholar
• Nolan M, Gronow S, Lapidus A, Ivanova N, Copeland A, Lucas S, Del Rio TG, Chen F, Tice H, Pitluck S, et al. 2009. Complete genome sequence of Streptobacillus moniliformis type strain (9901). Stand Genomic Sci. 1(3):300–307.
   PubMed Web of Science ®Google Scholar
• Noyes N, Cho K-C, Ravel J, Forney LJ, Abdo Z. 2018. Associations between sexual habits, menstrual hygiene practices, demographics and the vaginal microbiome as revealed by Bayesian network analysis. PLoS One. 13(1):e0191625.
   PubMed Web of Science ®Google Scholar
• Onderdonk AB, Delaney ML, Fichorova RN. 2016. The human microbiome during bacterial vaginosis. Clin Microbiol Rev. 29(2):223–238.
   PubMed Web of Science ®Google Scholar
• Onywera H, Williamson A-L, Mbulawa ZZA, Coetzee D, Meiring TL. 2019. The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection. Papillomavirus Res. 7:154–163.
   PubMed Web of Science ®Google Scholar
• Parry S, et al. 2020. Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth. Am J Obstet Gynecol. 222(5):493 e1–493 e13.
   PubMed Web of Science ®Google Scholar
• Pins MR, Holden JM, Yang JM, Madoff S, Ferraro MJ. 1996. Isolation of presumptive Streptobacillus moniliformis from abscesses associated with the female genital tract. Clin Infect Dis. 22(3):471–476.
   PubMed Web of Science ®Google Scholar
• Puri K, Taft DH, Ambalavanan N, Schibler KR, Morrow AL, Kallapur SG. 2016. Association of chorioamnionitis with aberrant neonatal gut colonization and adverse clinical outcomes. PLoS One. 11(9):e0162734.
   PubMed Web of Science ®Google Scholar
• Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SSK, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, et al. 2011. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 108(1):4680–4687.
   PubMedGoogle Scholar
• Redline RW. 2012. Inflammatory response in acute chorioamnionitis. Semin Fetal Neonatal Med. 17(1):20–25.
   PubMed Web of Science ®Google Scholar
• Rivkin A, Gim S. 2011. Rifaximin: new therapeutic indication and future directions. Clin Ther. 33(7):812–827.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaemsaithong P, Docheva N, Korzeniewski SJ, Tarca AL, Bhatti G, Xu Z, Kusanovic JP, Dong Z, Chaiyasit N, et al. 2016. Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile. J Perinat Med. 44(1):77–98.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaemsaithong P, Korzeniewski SJ, Kusanovic JP, Docheva N, Martinez-Varea A, Ahmed AI, Yoon BH, Hassan SS, Chaiworapongsa T, et al. 2016. Clinical chorioamnionitis at term III: how well do clinical criteria perform in the identification of proven intra-amniotic infection? J Perinat Med. 44(1):23–32.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaemsaithong P, Korzeniewski SJ, Tarca AL, Bhatti G, Xu Z, Kusanovic JP, Dong Z, Docheva N, Martinez-Varea A, et al. 2016. Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response. J Perinat Med. 44(1):5–22.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaiworapongsa T, Kuivaniemi H, Tromp G. 2004. Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth. Am J Obstet Gynecol. 190(6):1509–1519.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Kusanovic JP, Chaiworapongsa T, Chaemsaithong AM, Gotsch F, Dong Z, Ahmed AI, Shaman M, Lannaman K, et al. 2015. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques. J Perinat Med. 43(1):19–36.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaemsaithong P, Docheva N, Korzeniewski SJ, Tarca AL, Bhatti G, Xu Z, Kusanovic JP, Chaiyasit N, Dong Z, et al. 2016. Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response. J Perinat Med. 44(1):53–76.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaemsaithong P, Docheva N, Korzeniewski SJ, Kusanovic JP, Yoon BH, Kim J-S, Chaiyasit N, Ahmed A, Qureshi F, et al. 2016. Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity. J Perinat Med. 44(1):33–51.
   PubMed Web of Science ®Google Scholar
• Romero R, Gomez-Lopez N, Kusanovic JP, Pacora P, Panaitescu B, Erez O, Yoon BH. 2018. Clinical chorioamnionitis at term: new insights into the etiology, microbiology, and the fetal, maternal and amniotic cavity inflammatory responses. Nogyogyaszati Szuleszeti Tovabbkepzo Szemle. 20(3):103–112.
   PubMedGoogle Scholar
• Romero R, Gomez-Lopez N, Winters AD, Jung E, Shaman M, Bieda J, Panaitescu B, Pacora P, Erez O, Greenberg JM, et al. 2019. Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study. J Perinat Med. 47(9):915–931.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Chaemsaithong P, Chaiworapongsa T, Kusanovic JP, Dong Z, Ahmed AI, Shaman M, Lannaman K, Yoon BH, et al. 2015. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabour rupture of membranes. J Matern Fetal Neonatal Med. 28(12):1394–1409.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Chaiworapongsa T, Chaemsaithong P, Gotsch F, Dong Z, Ahmed AI, Yoon BH, Hassan SS, Kim CJ, et al. 2014. A novel molecular microbiologic technique for the rapid diagnosis of microbial invasion of the amniotic cavity and intra-amniotic infection in preterm labor with intact membranes. Am J Reprod Immunol. 71(4):330–358.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Chaiworapongsa T, Chaemsaithong P, Gotsch F, Dong Z, Ahmed AI, Yoon BH, Hassan SS, Kim CJ, et al. 2015. Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance. J Matern Fetal Neonatal Med. 28(11):1343–1359.
   PubMed Web of Science ®Google Scholar
• Rouse DJ, Landon M, Leveno KJ, Leindecker S, Varner MW, Caritis SN, O’Sullivan MJ, Wapner RJ, Meis PJ, Miodovnik M, et al. 2004. The Maternal-Fetal Medicine Units cesarean registry: chorioamnionitis at term and its duration-relationship to outcomes. Am J Obstet Gynecol. 191(1):211–216.
   PubMed Web of Science ®Google Scholar
• Sabo MC, Lehman DA, Wang B, Richardson BA, Srinivasan S, Osborn L, Matemo D, Kinuthia J, Fiedler TL, Munch MM, et al. 2020. Associations between vaginal bacteria implicated in HIV acquisition risk and proinflammatory cytokines and chemokines. Sex Transm Infect. 96(1):3–9.
   PubMed Web of Science ®Google Scholar
• Scarpignato C, Pelosini I. 2005. Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential. Chemotherapy. 51(1):36–66.
   PubMed Web of Science ®Google Scholar
• Schwebke JR, Muzny CA, Josey WE. 2014. Role of Gardnerella vaginalis in the pathogenesis of bacterial vaginosis: a conceptual model. J Infect Dis. 210(3):338–343.
   PubMed Web of Science ®Google Scholar
• Shane AL, Sanchez PJ, Stoll BJ. 2017. Neonatal sepsis. Lancet. 390(10104):1770–1780.
   PubMed Web of Science ®Google Scholar
• Shaw JL, Smith CR, Diamandis EP. 2007. Proteomic analysis of human cervico-vaginal fluid. J Proteome Res. 6(7):2859–2865.
   PubMed Web of Science ®Google Scholar
• Shukla SK, Meier PR, Mitchell PD, Frank DN, Reed KD. 2002. Leptotrichia amnionii sp. nov., a novel bacterium isolated from the amniotic fluid of a woman after intrauterine fetal demise. J Clin Microbiol. 40(9):3346–3349.
   PubMed Web of Science ®Google Scholar
• Sobel JD. 2000. Bacterial vaginosis. Annu Rev Med. 51:349–356.
   PubMed Web of Science ®Google Scholar
• Spear GT, Sikaroodi M, Zariffard MR, Landay AL, French AL, Gillevet PM. 2008. Comparison of the diversity of the vaginal microbiota in HIV-infected and HIV-uninfected women with or without bacterial vaginosis. J Infect Dis. 198(8):1131–1140.
   PubMed Web of Science ®Google Scholar
• Srinivasan S, Hoffman NG, Morgan MT, Matsen FA, Fiedler TL, Hall RW, Ross FJ, McCoy CO, Bumgarner R, Marrazzo JM, et al. 2012. Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria. PLoS One. 7(6):e37818.
   PubMed Web of Science ®Google Scholar
• Srinivasan S, Munch MM, Sizova MV, Fiedler TL, Kohler CM, Hoffman NG, Liu C, Agnew KJ, Marrazzo JM, Epstein SS, et al. 2016. More easily cultivated than identified: classical isolation with molecular identification of vaginal bacteria. J Infect Dis. 214(1):S21–S28.
   PubMedGoogle Scholar
• Steenbergen RDM, Snijders PJF, Heideman DAM, Meijer CJLM. 2014. Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions. Nat Rev Cancer. 14(6):395–405.
   PubMed Web of Science ®Google Scholar
• Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, Lochs H. 2005. Adherent biofilms in bacterial vaginosis. Obstet Gynecol. 106(5):1013–1023.
   PubMed Web of Science ®Google Scholar
• Swidsinski A, Verstraelen H, Loening-Baucke V, Swidsinski S, Mendling W, Halwani Z. 2013. Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One. 8(1):e53997.
   PubMed Web of Science ®Google Scholar
• Tamrakar R, Yamada T, Furuta I, Cho K, Morikawa M, Yamada H, Sakuragi N, Minakami H. 2007. Association between Lactobacillus species and bacterial vaginosis-related bacteria, and bacterial vaginosis scores in pregnant Japanese women. BMC Infect Dis. 7:128.
   PubMed Web of Science ®Google Scholar
• Taylor BD, Totten PA, Astete SG, Ferris MJ, Martin DH, Ness RB, Haggerty CL. 2018. Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease. Am J Reprod Immunol. 79(2):e12804.
   Web of Science ®Google Scholar
• Theis KR, Romero R, Motomura K, Galaz J, Winters AD, Pacora P, Miller D, Slutsky R, Florova V, Levenson D, et al. 2020. Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabour rupture of membranes. J Perinat Med. 48(2):115–131.
   PubMed Web of Science ®Google Scholar
• Tita AT, Andrews WW. 2010. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 37(2):339–354.
   PubMed Web of Science ®Google Scholar
• Urushiyama D, Suda W, Ohnishi E, Araki R, Kiyoshima C, Kurakazu M, Sanui A, Yotsumoto F, Murata M, Nabeshima K, et al. 2017. Microbiome profile of the amniotic fluid as a predictive biomarker of perinatal outcome. Sci Rep. 7(1):12171.
   PubMedGoogle Scholar
• van der Veer C, van Houdt R, van Dam A, de Vries H, Bruisten S. 2018. Accuracy of a commercial multiplex PCR for the diagnosis of bacterial vaginosis. J Med Microbiol. 67(9):1265–1270.
   PubMed Web of Science ®Google Scholar
• van Dillen J, Zwart J, Schutte J, van Roosmalen J. 2010. Maternal sepsis: epidemiology, etiology and outcome. Curr Opin Infect Dis. 23(3):249–254.
   PubMed Web of Science ®Google Scholar
• Vesty A, Gear K, Biswas K, Mackenzie BW, Taylor MW, Douglas RG. 2020. Oral microbial influences on oral mucositis during radiotherapy treatment of head and neck cancer. Support Care Cancer. 28(6):2683–2691.
   PubMed Web of Science ®Google Scholar
• Vitorino P, Varo R, Castillo P, Hurtado JC, Fernandes F, Valente AM, Mabunda R, Mocumbi S, Gary JM, Jenkinson TG, et al. 2019. Sneathia amnii and maternal chorioamnionitis and stillbirth, Mozambique. Emerg Infect Dis. 25(8):1614–1616.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang Y, Zhang Q, Chen H, Feng Y. 2018. Characterization of pelvic and cervical microbiotas from patients with pelvic inflammatory disease. J Med Microbiol. 67(10):1519–1526.
   PubMed Web of Science ®Google Scholar
• Wentzensen N, Vinokurova S, von Knebel Doeberitz M. 2004. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res. 64(11):3878–3884.
   PubMed Web of Science ®Google Scholar
• Willi MJ, et al. 2002. Chorioamnionitis: elevated interleukin-6 and interleukin-8 concentrations in the lower uterine segment. J Perinat Med. 30(4):292–296.
   PubMed Web of Science ®Google Scholar
• Yeoman CJ, Yildirim S, Thomas SM, Durkin AS, Torralba M, Sutton G, Buhay CJ, Ding Y, Dugan-Rocha SP, Muzny DM, et al. 2010. Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential. PLoS One. 5(8):e12411.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang L, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, Hong Y, Wang X, Tian J, et al. 2019. Patients with LR-HPV infection have a distinct vaginal microbiota in comparison with healthy controls. Front Cell Infect Microbiol. 9:294.
   PubMed Web of Science ®Google Scholar
• Zur Hausen H. 1996. Papillomavirus infections–a major cause of human cancers. Biochim Biophys Acta. 1288(2):F55–F78.
   PubMed Web of Science ®Google Scholar