Bacillus spore-forming probiotics: benefits with concerns?

References

• Abhari K, Shekarforoush SS, Hosseinzadeh S, Nazifi S, Sajedianfard J, Eskandari MH. 2016. The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats. Food Nutr Res. 60(1):30876.
   PubMed Web of Science ®Google Scholar
• Adimpong DB, Sørensen KI, Thorsen L, Stuer-Lauridsen B, Abdelgadir WS, Nielsen DS, Derkx PM, Jespersen L. 2012. Antimicrobial susceptibility of Bacillus strains isolated from primary starters for African traditional bread production and characterization of the bacitracin operon and bacitracin biosynthesis. Appl Environ Microbiol. 78(22):7903–7914.
   PubMed Web of Science ®Google Scholar
• Agersø Y, Jensen LB, Givskov M, Roberts MC. 2002. The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group. FEMS Microbiol Lett. 214(2):251–256.
   PubMed Web of Science ®Google Scholar
• Albuquerque DM, Marengoni NG, Boscolo WR, Ribeiro RP, Mahl I, Moura MC. 2013. Probióticos em dietas para tilápia do Nilo durante a reversão sexual. Cienc Rural. 43(8):1503–1508.
   Google Scholar
• Altmeyer S, Kröger S, Vahjen W, Zentek J, Scharek-Tedin L. 2014. Impact of a probiotic Bacillus cereus strain on the jejunal epithelial barrier and on the NKG2D expressing immune cells during the weaning phase of piglets. Vet Immunol Immunopathol. 161(1-2):57–65.
   PubMed Web of Science ®Google Scholar
• Amerah A, Quiles A, Medel P, Sanchez J, Lehtinen M, Gracia M. 2013. Effect of pelleting temperature and probiotic supplementation on growth performance and immune function of broilers fed maize/soy-based diets. Anim Feed Sci Technol. 180(1–4):55–63.
   Web of Science ®Google Scholar
• Amuguni JH, Lee S, Kerstein KO, Brown DW, Belitsky BR, Herrmann JE, Keusch GT, Sonenshein AL, Tzipori S. 2011. Sublingually administered Bacillus subtilis cells expressing tetanus toxin C fragment induce protective systemic and mucosal antibodies against tetanus toxin in mice. Vaccine. 29(29–30):4778–4784.
   PubMed Web of Science ®Google Scholar
• Anjos TR, Cavicchioli VQ, Lima JAS, Vasconcellos AN, Vaz ACN, Rossi GAM, Campos-Galvão MEM, Todorov SD, Mathias LA, Schocken-Iturrino RP, et al. 2020. Unsatisfactory microbiological aspects of UHT goat milk, soymilk and dairy beverage of goat milk and soy protein: a public health issue. Food Sci Technol. 40(Suppl. 1):349–354.
   Google Scholar
• Apetroaie-Constantin C, Mikkola R, Andersson M, Teplova V, Suominen I, Johansson T, Salkinoja-Salonen M. 2009. Bacillus subtilis and B. mojavensis strains connected to food poisoning produce the heat stable toxin amylosin. J Appl Microbiol. 106(6):1976–1985.
   PubMed Web of Science ®Google Scholar
• Baccigalupi L, Ricca E, Ghelardi E. 2015. Non-LAB probiotics: spore formers. In: Venema K, do Carmo AP, editors. Probiotics and prebiotics: current research and future trends. Poole: Caister Academic Press, p. 93–104.
   Google Scholar
• Barbosa TM, Serra CR, La Ragione RM, Woodward MJ, Henriques AO. 2005. Screening for Bacillus isolates in the broiler gastrointestinal tract. Appl Environ Microbiol. 71(2):968–978.
   PubMed Web of Science ®Google Scholar
• Begley M, Cotter PD, Hill C, Ross RP. 2009. Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol. 75(17):5451–5460.
   PubMed Web of Science ®Google Scholar
• Beliavskaia VA, Kashperova TA, Bondarenko VM, Il’ichev AA, Sorokulova IB, Malik NI. 2001. Experimental evaluation of the biological safety of gene engineered bacteria using a model strain Bacillus subtilis interferon-producing strain. Z Mikrobiol Epidemiol Immunobiol. 2:16–20.
   Google Scholar
• Berdy J. 2005. Bioactive microbial metabolites – a personal view. J Antibiot. 58:1–26.
   PubMed Web of Science ®Google Scholar
• Berestovaya TG, Rudenko AA, Sorokulova IB, Muravskaya LV, Hunas IV, et al. 1999. Clinical efficacy of subalin at meningoenzephalitis. Farmacol Visnik. 6:24–28.
   Google Scholar
• Borriss R. 2020. Phytostimulation and biocontrol by the plant-associated Bacillus amyloliquefaciens FZB42: an update. In: Kumar M, Kumar V, Prasad R, editors. Phyto-microbiome in stress regulation. Environmental and microbial biotechnology. Singapore: Springer.
   Google Scholar
• Berthold-Pluta A, Pluta A, Garbowska M. 2015. The effect of selected factors on the survival of Bacillus cereus in the human gastrointestinal tract. Microb Pathog. 82:7–14.
   PubMed Web of Science ®Google Scholar
• Bozdogan B, Galopin S, Gerbaud G, Courvalin P, Leclercq R. 2003. Chromosomal aadD2 encodes an aminoglycoside nucleotidyltransferase in Bacillus clausii. Antimicrob Agents Chemother. 47(4):1343–1346.
   PubMed Web of Science ®Google Scholar
• Bozdogan B, Galopin S, Leclercq R. 2004. Characterization of a new erm-related macrolide resistance gene present in probiotic strains of Bacillus clausii. Appl Environ Microbiol. 70(1):280–284.
   PubMed Web of Science ®Google Scholar
• Cabello FC, Godfrey HP, Buschmann AH, Dolz HJ. 2016. Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial resistance. Lancet Infect Dis. 16(7):e127–e133.
   PubMed Web of Science ®Google Scholar
• Cai D, Liu M, Wei X, Li X, Wang Q, Nomura CT, Chen S. 2017. Use of Bacillus amyloliquefaciens HZ-12 for High-Level Production of the Blood Glucose Lowering Compound, 1-Deoxynojirimycin (DNJ), and Nutraceutical Enriched Soybeans via Fermentation. Appl Biochem Biotechnol. 181(3):1108–1122.
   PubMed Web of Science ®Google Scholar
• Cano RJ, Borucki MK, Higby-Schweitzer M, Poinar HN, Poinar GO Jr., Pollard KL. 1994. Bacillus DNA in fossil bees: an ancient symbiosis? Appl Environ Microbiol. 60(6):2164–2167.
   PubMed Web of Science ®Google Scholar
• Cano RJ, Borucki MK. 1995. Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amber. Science. 268(5213):1060–1064.
   PubMed Web of Science ®Google Scholar
• Casula G, Cutting SM. 2002. Bacillus probiotics: spore germination in the gastrointestinal tract. Appl Environ Microbiol. 68(5):2344–2352.
   PubMed Web of Science ®Google Scholar
• Celandroni F, Salvetti S, Gueye SA, Mazzantini D, Lupetti A, Senesi S, Ghelardi E. 2016. Identification and pathogenic potential of clinical Bacillus and Paenibacillus isolates. PLOS One. 11(3):e0152831.
   PubMed Web of Science ®Google Scholar
• Chaves JQ, Pires ES, Vivoni AM. 2011. Genetic diversity, antimicrobial resistance and toxigenic profiles of Bacillus cereus isolated from food in Brazil over three decades. Int J Food Microbiol. 147(1):12–16.
   PubMed Web of Science ®Google Scholar
• Chikindas ML, Weeks R, Drider D, Chistyakov VA, Dicks LM. 2018. Functions and emerging applications of bacteriocins. Curr Opin Biotechnol. 49:23–28.
   PubMed Web of Science ®Google Scholar
• Choi JH, Pichiah PB, Kim MJ, Cha YS. 2016. Cheonggukjang, a soybean paste fermented with B. licheniformis-67 prevents weight gain and improves glycemic control in high fat diet induced obese mice. J Clin Biochem Nutr. 59(1):31–38.
   PubMed Web of Science ®Google Scholar
• Chudnovskaya NV, Ribalko SL, Sorokulova IB, Smirnov VV, Belyavskaya VA. 1995. Antiviral activity of Bacillus probiotics. Dopovidi Nac Acad Nauk Ukraini. 124–126.
   Google Scholar
• Ciffo F. 1984. Determination of the spectrum of antibiotic resistance of the “Bacillus subtilis” strains of Enterogermina. Chemioterapia. 3(1):45–52.
   PubMedGoogle Scholar
• Cutting SM. 2011. Bacillus probiotics. Food Microbiol. 28(2):214–220.
   PubMed Web of Science ®Google Scholar
• Cutting SM, Van PH, Dong TC. 2009. Bacillus probiotics. Nutra Foods. 8:7–14.
   Google Scholar
• D'Arienzo R, Maurano F, Mazzarella G, Luongo D, Stefanile R, Ricca E, Rossi M. 2006. Bacillus subtilis spores reduce susceptibility to Citrobacter rodentium-mediated enteropathy in a mouse model. Res Microbiol. 157(9):891–897.
   PubMed Web of Science ®Google Scholar
• Dai M, Lu J, Wang Y, Liu Z, Yuan Z. 2012. In vitro development and transfer of resistance to chlortetracycline in Bacillus subtilis. J Microbiol. 50(5):807–812.
   PubMed Web of Science ®Google Scholar
• Dioso CM, Vital P, Arellano K, Park H, Todorov SD, Ji Y, Holzapfel W. 2020. Do your kids get what you paid for? evaluation of commercially available probiotic products intended for children in the Republic of the Philippines and the Republic of Korea. Foods. 9(9):1229.
   Web of Science ®Google Scholar
• Duc LH, Hong HA, Atkins HS, Flick-Smith HC, Durrani Z, Rijpkema S, Titball RW, Cutting SM. 2007. Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen. Vaccine. 25(2):346–355.
   PubMed Web of Science ®Google Scholar
• Duc LH, Hong HA, Barbosa TM, Henriques AO, Cutting SM. 2004. Characterization of Bacillus probiotics available for human use. Appl Environ Microbiol. 70(4):2161–2171.
   PubMed Web of Science ®Google Scholar
• Dudonné S, Varin TV, Anhê FF, Dubé P, Roy D, Pilon G, Marette A, Levy E, Jacquot C, Urdaci M, et al. 2015. Modulatory effects of a cranberry extract co-supplementation with Bacillus subtilis CU1 probiotic on phenolic compounds bioavailability and gut microbiota composition in high-fat diet-fed mice. Pharma Nutr. 3(3):89–100.
   Google Scholar
• Ehling-Schulz M, Fricker M, Scherer S. 2004. Identification of emetic toxin producing Bacillus cereus strains by a novel molecular assay. FEMS Microbiol Lett. 232(2):189–195.
   PubMed Web of Science ®Google Scholar
• Elshaghabee FMF, Rokana N, Gulhane RD, Sharma C, Panwar H. 2017. Bacillus as potential probiotics: status, concerns, and future perspectives. Front Microbiol. 8:1490.
   PubMed Web of Science ®Google Scholar
• Endres JR, Clewell A, Jade KA, Farber T, Hauswirth J, Schauss AG. 2009. Safety assessment of a proprietary preparation of a novel Probiotic, Bacillus coagulans, as a food ingredient. Food Chem Toxicol. 47(6):1231–1238.
   PubMed Web of Science ®Google Scholar
• Errington J. 2003. Regulation of endospore formation in Bacillus subtilis. Nat Rev Microbiol. 1(2):117–126.
   PubMed Web of Science ®Google Scholar
• Feng F, Hu P, Chen L, Tang Q, Lian CQ, Yao Q, Chen K. 2013. Display of human proinsulin on the Bacillus subtilis spore surface for oral administration. Curr Microbiol. 67(1):1–8.
   PubMed Web of Science ®Google Scholar
• Field D, Cotter PD, Hill C, Ross RP. 2015. Bioengineering lantibiotics for therapeutic success. Front Microbiol. 6:1363.
   PubMed Web of Science ®Google Scholar
• Foligné B, Peys E, Vandenkerckhove J, Van Hemel J, Dewulf J, Breton J, Pot B. 2012. Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice. Clin Nutr. 31(6):987–994.
   PubMed Web of Science ®Google Scholar
• Fooks LJ, Fuller R, Gibson GR. 1999. Prebiotics, probiotics and human gut microbiology. Int Dairy J. 9(1):53–61.
   Web of Science ®Google Scholar
• Fujiya M, Musch MW, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB. 2007. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 1(4):299–308.
   PubMed Web of Science ®Google Scholar
• From C, Hormazabal V, Granum PE. 2007. Food poisoning associated with pumilacidin-producing Bacillus pumilus in rice. Int J Food Microbiol. 115(3):319–324.
   PubMed Web of Science ®Google Scholar
• Galopin S, Cattoir V, Leclercq R. 2009. A chromosomal chloramphenicol acetyltransferase determinant from a probiotic strain of Bacillus clausii. FEMS Microbiol Lett. 296(2):185–189.
   PubMed Web of Science ®Google Scholar
• Garcia-Marengoni N, de Moura MC, de Oliveira NTE, Bombardelli RA, Menezes-Albuquerque D. 2017. Use of probioitcs Bacillus cereus var. toyoi and Bacillus subtilis C-3102 in the diet of juvenile Nile tilapia cultured in cages. Lat Am J Aquat Res. 43(3):601–606.
   Web of Science ®Google Scholar
• Ghelardi E, Celandroni F, Salvetti S, Gueye SA, Lupetti A, Senesi S. 2015. Survival and persistence of Bacillus clausii in the human gastrointestinal tract following oral administration as spore-based probiotic formulation. J Appl Microbiol. 119(2):552–559.
   PubMed Web of Science ®Google Scholar
• Ghoneim MAM, Hassan AI, Mahmoud MG, Asker MS. 2016. Effect of polysaccharide from Bacillus subtilis sp. on cardiovascular diseases and atherogenic indices in diabetic rats. BMC Complement Altern Med. 16(1):112.
   PubMedGoogle Scholar
• Girlich D, Leclercq R, Naas T, Nordmann P. 2007. Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. Antimicrob Agents Chemother. 51(11):4009–4014.
   PubMed Web of Science ®Google Scholar
• Gong Y, Li H, Li Y. 2016. Effects of Bacillus subtilis on epithelial tight junctions of mice with inflammatory bowel disease. J Interferon Cytokine Res. 36(2):75–85.
   PubMed Web of Science ®Google Scholar
• Granum PE, Lund T. 1997. Bacillus cereus and its food poisoning toxins. FEMS Microbiol Lett. 157(2):223–228.
   PubMed Web of Science ®Google Scholar
• Green DH, Wakeley PR, Page A, Barnes A, Baccigalupi L, Ricca E, Cutting S. 1999. Characterization of two Bacillus probiotics. Appl Environ Microbiol. 65(9):4288–4291.
   PubMed Web of Science ®Google Scholar
• Gryczan T, Israeli-Reches M, Del Bue M, Dubnau D. 1984. DNA sequence and regulation of ermD, a macrolide-lincosamide-streptogramin B resistance element from Bacillus licheniformis. Mol Gen Genet. 194(3):349–356.
   PubMedGoogle Scholar
• Guarner F, Malagelada JR. 2003. Gut flora in health and disease. Lancet. 361(9356):512–519.
   PubMed Web of Science ®Google Scholar
• Guo JJ, Liu KF, Cheng SH, Chang CI, Lay JJ, Hsu YO, Yang JY, Chen TI. 2009. Selection of probiotic bacteria for use in shrimp larvi culture. Aquacult Res. 40(5):609–618.
   Web of Science ®Google Scholar
• Haldar L, Gandhi DN. 2016. Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model. Vet World. 9(7):766–772.
   PubMed Web of Science ®Google Scholar
• Hamilton-Miller JM, Shah S, Winkler JT. 1999. Public health issues arising from microbiological and labelling quality of foods and supplements containing probiotic microorganisms. Public Health Nutr. 2(2):223–229.
   PubMed Web of Science ®Google Scholar
• Heng N, Tagg J. 2006. What’s in a name? Class distinction for bacteriocins. Nat Rev Microbiol. 4(2):160–160.
   Web of Science ®Google Scholar
• Hoa NT, Baccigalupi L, Huxham A, Smertenko A, Van PH, Ammendola S, Ricca E, Cutting AS. 2000. Characterization of Bacillus species used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders. Appl Environ Microbiol. 66(12):5241–5247.
   PubMed Web of Science ®Google Scholar
• Hong H, Huang J-M, Khaneja R, Hiep L, Urdaci M, Cutting S. 2008. The safety of Bacillus subtilis and Bacillus indicus as food probiotics. J Appl Microbiol. 105(2):510–520.
   PubMed Web of Science ®Google Scholar
• Hosoi T, Kiuchi K. 2003. Natto‚ a food made by fermenting cooked soybeans with Bacillus subtilis (natto). In: Handbook of fermented functional foods. Boca Raton (FL): CRC Press; p. 227–250.
   Google Scholar
• Hu Y, Dun Y, Li S, Zhao S, Peng N, Liang Y. 2014. Effects of Bacillus subtilis KN-42 on growth performance, diarrhea and faecal bacterial flora of weaned piglets. Asian Australas J Anim Sci. 27(8):1131–1140.
   PubMed Web of Science ®Google Scholar
• Hyronimus B, Le Marrec C, Sassi AH, Deschamps A. 2000. Acid and bile tolerance of spore-forming lactic acid bacteria. Int J Food Microbiol. 61(2-3):193–197.
   PubMed Web of Science ®Google Scholar
• Isticato R, Cangiano G, Tran HT, Ciabattini A, Medaglini D, Oggioni MR, De Felice M, Pozzi G, Ricca E. 2001. Surface display of recombinant proteins on Bacillus subtilis spores. J Bacteriol. 183(21):6294–6301.
   PubMed Web of Science ®Google Scholar
• Jeon YL, Yang JJ, Kim MJ, Lim G, Cho SY, Park TS, Suh J-T, Park YH, Lee MS, Kim SC, et al. 2012. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol. 61(Pt 12):1766–1769.
   PubMed Web of Science ®Google Scholar
• Katz E, Demain AL. 1977. The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. Bacteriol Rev. 41(2):449–474.
   PubMedGoogle Scholar
• Kawai Y, Kemperman R, Kok J, Saito T. 2004. The circular bacteriocins gassericin A and circularin A. Curr Protein Pept Sci. 5(5):393–398.
   PubMed Web of Science ®Google Scholar
• Karu R, Sumeri I. 2016. Survival of Lactobacillus rhamnosus GG during simulated gastrointestinal conditions depending on food matrix. J Food Res. 5:57–66.
   Google Scholar
• Khatri I, Sharma G, Subramanian S. 2019. Composite genome sequence of Bacillus clausii, a probiotic commercially available as Enterogermina®, and insights into its probiotic properties. BMC Microbiol. 19(1):307.
   PubMed Web of Science ®Google Scholar
• Kim JH, Roh C, Lee CW, Kyung D, Choi SK, Jung HC, Pan JG, Kim BG. 2007. Bacterial surface display of GFP(UV) on Bacillus subtilis spores. J Microbiol Biotechnol. 17(4):677–680.
   PubMed Web of Science ®Google Scholar
• Kim M-J, Han J-K, Park J-S, Lee J-S, Lee S-H, Cho J-I, Kim K-S. 2015. Various enterotoxin and other virulence factor genes widespread among Bacillus cereus and Bacillus thuringiensis strains. J Microbiol Biotechnol. 25(6):872–879.
   PubMed Web of Science ®Google Scholar
• Kniehl E, Becker A, Forster DH. 2003. Pseudo-outbreak of toxigenic Bacillus cereus isolated from stools of three patients with diarrhoea after oral administration of a probiotic medication. J Hosp Infect. 55(1):33–38.
   PubMed Web of Science ®Google Scholar
• Koh M, Hanagata H, Ebisu S, Morihara K, Takagi H. 2000. Use of Bacillus brevis for synthesis and secretion of Des-B30 single-chain human insulin precursor. Biosci Biotechnol Biochem. 64(5):1079–1081.
   PubMed Web of Science ®Google Scholar
• Kosak T, Maeda T, Nakada Y, Yukawa M, Tanaka S. 1998. Effect of Bacillus subtilis spore administration on activation of macrophages and natural killer cells in mice. Vet Microbiol. 60(2-4):215–225.
   PubMed Web of Science ®Google Scholar
• Kramer JM, Gilbert RJ. 1989. Bacillus cereus and other Bacillus species. In: Doyle MP, editor. Foodborne bacterial pathogens. New York (NY): Marcel Dekker Inc.; p. 21–50.
   Google Scholar
• Kyriakis SC, Tsiloyiannis VK, Vlemmas J, Sarris K, Tsinas AC, Alexopoulos C, Jansegers L. 1999. The effect of probiotic LSP 122 on the control of post-weaning diarrhoea syndrome of piglets. Res Vet Sci. 67(3):223–228.
   PubMed Web of Science ®Google Scholar
• La Ragione RM, Casula G, Cutting SM, Woodward SM. 2001. Bacillus subtilis spores competitively exclude Escherichia coli 070:K80 in poultry. Vet Microbiol. 79(2):133–142.
   PubMed Web of Science ®Google Scholar
• Lee J, Park I, Choi Y, Cho J. 2012. Bacillus strains as feed additives: In vitro evaluation of its potential probiotic properties. Rev Colomb Cienc Pecu. 25:577–585.
   Web of Science ®Google Scholar
• Lee N, Kim M-D, Chang H-J, Choi S-W, Chun HS. 2017. Genetic diversity, antimicrobial resistance, toxin gene profiles, and toxin production ability of Bacillus cereus isolates from doenjang, a Korean fermented soybean paste. J Food Saf. 37(4):e12363.
   Web of Science ®Google Scholar
• Lee NK, Kim WS, Paik HD. 2019. Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier. Food Sci Biotechnol. 28(5):1297–1305.
   PubMed Web of Science ®Google Scholar
• Lee S, Belitsky BR, Brinker JP, Kerstein KO, Brown DW, Clements JD, Keusch GT, Tzipori S, Sonenshein AL, Herrmann JE. 2010. Development of a Bacillus subtilis-based rotavirus vaccine. Clin Vaccine Immunol. 17(11):1647–1655.
   PubMed Web of Science ®Google Scholar
• Lee Y, Yoshitsugu R, Kikuchi K, Joe G-H, Tsuji M, Nose T, Shimizu H, Hara H, Minamida K, Miwa K, et al. 2016. Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet. Br J Nutr. 116(4):603–610.
   PubMed Web of Science ®Google Scholar
• Leser TD, Knarreborg A, Worm J. 2008. Germination and outgrowth of Bacillus subtilis and Bacillus licheniformis spores in the gastrointestinal tract of pigs. J Appl Microbiol. 104(4):1025–1033.
   PubMed Web of Science ®Google Scholar
• Lippolis R, Siciliano RA, Mazzeo MF, Abbrescia A, Gnoni A, Sardanelli AM, Papa S. 2013. Comparative secretome analysis of four isogenic Bacillus clausii probiotic strains. Proteome Sci. 11(1):28.
   PubMed Web of Science ®Google Scholar
• Litviakov NV, Cherdyntseva NV, Beliavskaia VA, Malinovskaia EA, Il'inykh IS, Smol'ianinov ES. 2001. Role of macrophages in the antitumor action of the recombinant probiotic Subalin. Vopr Onkol. 47(1):86–89.
   PubMedGoogle Scholar
• Liu Z, Budiharjo A, Wang P, Shi H, Fang J, Borriss R, Zhang K, Huang X. 2013. The highly modified microcin peptide plantazolicin is associated with nematicidal activity of Bacillus amyloliquefaciens FZB42. Appl Microbiol Biotechnol. 97(23):10081–10090.
   PubMed Web of Science ®Google Scholar
• Lopetuso LR, Scaldaferri F, Franceschi F, Gasbarrini A. 2016. Bacillus clausii and gut homeostasis: state of the art and future perspectives. Expert Rev Gastroenterol Hepatol. 10(8):943–946.
   PubMed Web of Science ®Google Scholar
• Luis-Villasenor IE, Macıas-Rodrıguez ME, Gomez-Gil B, Ascencio-Valle F, Campa-Cordova AI. 2011. Beneficial effects of four Bacillus strains on the larval cultivation of Litopenaeus vannamei. Aqua. 321(1–2):136–144.
   Google Scholar
• Mao LY, Jiang ST, Li GH, He YQ, Chen L, Yao Q, Chen K. 2012. Surface display of human serum albumin on Bacillus subtilis spores for oral administration. Curr Microbiol. 64(6):545–551.
   PubMed Web of Science ®Google Scholar
• Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K. 2011. Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl Environ Microbiol. 77(22):8164–8170.
   PubMed Web of Science ®Google Scholar
• Mazza P, Zani F, Martelli P. 1992. Studies on the antibiotic resistance of Bacillus subtilis strains used in oral bacteriotherapy. Boll Chim Farm. 131(11):401–408.
   PubMedGoogle Scholar
• McAuliffe O, Ryan MP, Ross RP, Hill C, Breeuwer P, Abee T. 1998. Lacticin 3147, a broad-spectrum bacteriocin which selectively dissipates the membrane potential. Appl Environ Microbiol. 64(2):439–445.
   PubMed Web of Science ®Google Scholar
• Messelhäußer U, Ehling-Schulz M. 2018. Bacillus cereus—a multifaceted opportunistic pathogen. Curr Clin Micro Rpt. 5(2):120–125.
   Web of Science ®Google Scholar
• Mikkola R, Andersson MA, Teplova V, Grigoriev P, Kuehn T, Loss S, Tsitko I, Apetroaie C, Saris N-EL, Veijalainen P, Salkinoja-Salonen MS. 2007. Amylosin from Bacillus amyloliquefaciens, a K+ and Na+ channel-forming toxic peptide containing a polyenestructure. Toxicon. 49(8):1158–1171. doi: https://doi.org/https://doi.org/10.1016/j.toxicon.2007.02.010.
   PubMed Web of Science ®Google Scholar
• Mingmongkolchai S, Panbangred W. 2018. Bacillus probiotics: an alternative to antibiotics for livestock production. J Appl Microbiol. 124(6):1334–1346.
   PubMed Web of Science ®Google Scholar
• Mohapatra S, Chakraborty T, Kumar V, DeBoeck G, Mohanta KN. 2013. Aquaculture and stress management: a review of probiotic intervention. J Anim Physiol Anim Nutr. 97(3):405–430.
   PubMed Web of Science ®Google Scholar
• Mu Y, Cong Y. 2019. Bacillus coagulans and its applications in medicine. Benef Microbes. 10(6):679–688.
   PubMed Web of Science ®Google Scholar
• Mullany P, Barbosa TM, Scott K, Roberts AP. 2004. Mechanisms of gene transfer and the spread of antibiotic resistance in spore forming organisms in the GI tract. In: Ricca E, Henriques AO, Cutting SM, editors. Bacterial spore formers: probiotics and emerging applications. Norfolk: Horizon Bioscience; p. 113–129.
   Google Scholar
• Nakandakare IB, Iwashita MKP, Dias DC, Tachibana L, Ranzani-Paiva MJT, Romagosa E. 2013. Incorporação de probióticos na dieta para juvenis de tilapias-do-Nilo: parâmetros hemato-lógicos, imunológicos e microbiológicos. Bol Inst Pesca. 39(2):121–135.
   Google Scholar
• Nicholson WL, Munakata N, Horneck G, Melosh HJ, Setlow P. 2000. Resistance of Bacillus endospores to extreme terrestrial and extraterrestrial environments. Microbiol Mol Biol Rev. 64(3):548–572.
   PubMed Web of Science ®Google Scholar
• Noor Uddin GM, Larsen MH, Christensen H, Aarestrup FM, Phu TM, Dalsgaard A. 2015. Identification and antimicrobial resistance of bacteria isolated from probiotic products used in shrimp culture. PLOS One. 10(7):e0132338.
   PubMed Web of Science ®Google Scholar
• Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, et al. 2012. Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and d cytoprotection. Int J Colorectal Dis. 27(8):1039–1046.
   PubMed Web of Science ®Google Scholar
• Okazaki H, Kishi T, Beppu T, Arima K. 1975. Letter: a new antibiotic, baciphelacin. J Antibiot. 28(9):717–719.
   PubMed Web of Science ®Google Scholar
• Olmos J, Paniagua-Michel J. 2014. Bacillus subtilis a potential probiotic bacterium to formulate functional feeds for aquaculture. J Microb Biochem Technol. 06(07):361–365.
   Google Scholar
• Olmos-Soto J, Contreras-Flores R. 2003. Genetic system constructed to overproduce and secrete proinsulin in Bacillus subtilis. Appl Microbiol Biotechnol. 62(4):369–373.
   PubMed Web of Science ®Google Scholar
• Ozawa K, Yabu-Uchi K, Yamanaka K, Yamashita Y, Ueba K, Miwatani T. 1979. Antagonistic effects of Bacillus natto and Streptococcus faecalis on growth of Candida albicans. Microbiol Immunol. 23:12–19.
   Web of Science ®Google Scholar
• Ozawa K, Yokota H, Kimura M, Mitsuoka T. 1981. Effects of administration of Bacillus subtilis strain BN on intestinal flora of weanling piglets. Nihon Juigaku Zasshi. 43(5):771–775.
   PubMedGoogle Scholar
• Padhi TR, Sharma S, Das S, Das T. 2012. Bacillus licheniformis as a cause of delayed-onset recurrent pseudophakic endophthalmitis-a rare case report. Retin Cases Brief Rep. 6(1):43–45.
   PubMedGoogle Scholar
• Panwar P, Srivastava PK, Kapoor M. 2014. Production, extraction and characterization of alkaline xylanase from Bacillus sp. PKD-9 with potential for poultry feed. Biocatal Agric Biotechnol. 3(2):118–125.
   Google Scholar
• Park DJ, Yun JC, Baek JE, Jung EY, Lee DW, Kim MA, Chang SH. 2006. Relapsing Bacillus licheniformis peritonitis in a continuous ambulatory peritoneal dialysis patient. Nephrology. 11(1):21–22.
   PubMed Web of Science ®Google Scholar
• Patrone V, Molinari P, Morelli L. 2016. Microbiological and molecular characterization of commercially available probiotics containing Bacillus clausii from India and Pakistan. Int J Food Microbiol. 237:92–97.
   PubMed Web of Science ®Google Scholar
• Pereira GVM, Neto DPC, Junqueira ACO, Karp SG, Letti LAJ, Magalhães Junior AI, Soccol CR. 2020. A review of selection criteria for starter cultures developing in the food fermentation industry. Food Rev Int. 36(2):135–167.
   Google Scholar
• Pinchuk IV, Bressollier P, Verneuil B, Fenet B, Sorokulova IB, Megraud F, Urdaci MC. 2001. In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics. Antimicrob Agents Chemother. 45(11):3156–3161.
   PubMed Web of Science ®Google Scholar
• Porzio S, Bossu P, Ruggiero P, Boraschi D, Tagliabue A. 2004. Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria. BMC Biotechnol. 4(1):27.
   PubMedGoogle Scholar
• Pradhan B, Guha D, Ray P, Das D, Aich P. 2016. Comparative analysis of the effects of two probiotic bacterial strains on metabolism and innate immunity in the RAW 264.7 murine macrophage cell line. Probiotics Antimicrob Proteins. 8(2):73–84.
   PubMed Web of Science ®Google Scholar
• Prokesova L, Novakova M, Julak J, Mara M. 1994. Effect of Bacillus firmus and other sporulating aerobic microorganisms on in vitro stimulation of human lymphocytes. A comparative study. Folia Microbiol. 39:501–504.
   PubMed Web of Science ®Google Scholar
• Rengpipat S, Phianphak W, Piyatiratitivorakul S, Menasveta P. 1998. Effects of a probiotic bacterium on black tiger shrimp Penaeus monodon survival and growth. Aquaculture. 167(3–4):301–313.
   Web of Science ®Google Scholar
• Ripert G, Racedo SM, Elie A-M, Jacquot C, Bressollier P, Urdaci MC. 2016. Secreted compounds of the probiotic Bacillus clausii strain O/C inhibit the cytotoxic effects induced by Clostridium difficile and Bacillus cereus toxins. Antimicrob Agents Chemother. 60(6):3445–3454.
   PubMed Web of Science ®Google Scholar
• Rivis O, Kryvtsova M, Nikolajchuk V. 2013. Antagonistic activity of Bacillus probiotics against bacteria isolates of oral cavity of patients with periodontitis. Regul Mech Biosyst. 4(1). https://cyberleninka.ru/article/n/antagonistic-activity-of-bacillus-probiotics-against-bacteria-isolates-of-oral-cavity-of-patients-with-periodontitis.
   Google Scholar
• Rowan NJ, Deans K, Anderson JG, Gemmell CG, Hunter IS, Chaithong T. 2001. Putative virulence factor expression by clinical and food isolates of Bacillus spp. after growth in reconstituted infant milk formulae. Appl Environ Microbiol. 67(9):3873–3881.
   PubMed Web of Science ®Google Scholar
• Saising J, Dube L, Ziebandt A-K, Voravuthikunchai SP, Nega M, Götz F. 2012. Activity of gallidermin on Staphylococcus aureus and Staphylococcus epidermidis biofilms. Antimicrob Agents Chemother. 56(11):5804–5810.
   PubMed Web of Science ®Google Scholar
• Sánchez B, Arias S, Chaignepain S, Denayrolles M, Schmitter JM, Bressollier P, Urdaci MC. 2009. Identification of surface proteins involved in the adhesion of a probiotic Bacillus cereus strain to mucin and fibronectin. Microbiol. 155(5):1708–1716.
   PubMedGoogle Scholar
• Salkinoja-Salonen M, Vuorio R, Andersson M, Kampfer P, Andersson M, Honkanen-Buzalski T, Scoging A. 1999. Toxigenic strains of Bacillus licheniformis related to food poisoning. Appl Environ Microbiol. 65(10):4637–4645.
   PubMed Web of Science ®Google Scholar
• Sanders ME, Morelli L, Tompkins TA. 2003. Sporeformers as human probiotics: Bacillus, Sporolactobacillus, and Brevibacillus. Compr Rev Food Sci Food Saf. 2(3):101–110.
   PubMedGoogle Scholar
• Schierack P, Wieler LH, Taras D, Herwig V, Tachu B, Hlinak A, Schmidt MFG, Scharek L. 2007. Bacillus cereus var. toyoi enhanced systemic immune response in piglets. Vet Immunol Immunopathol. 118(1-2):1–11.
   PubMed Web of Science ®Google Scholar
• Schultz M, Burton JP, Chanyi RM. 2017. Use of Bacillus in human intestinal probiotic applications. The microbiota in gastrointestinal pathophysiology. Implications for human health, prebioitcs, and Dysbiosis. Cambridge, MA: Academic Press; p. 119–123.
   Google Scholar
• Sella SRBR, Vandenberghe LPS, Soccol CR. 2014. Life cycle and spore resistance of spore-forming Bacillus atrophaeus. Microbiol Res. 169(12):931–939.
   PubMedGoogle Scholar
• Senesi S, Celandroni F, Tavanti A, Ghelardi E. 2001. Molecular characterization and identification of Bacillus clausii strains marketed for use in oral bacteriotherapy. Appl Environ Microbiol. 67(2):834–839.
   PubMed Web of Science ®Google Scholar
• Serra CR, Almeida EM, Guerreiro I, Santos R, Merrifield DL, Tavares F, Oliva-Teles A, Enes P. 2019. Selection of carbohydrate-active probiotics from the gut of carnivorous fish fed plant-based diets. Sci Rep. 9(1):6384
   PubMedGoogle Scholar
• Shelburne CE, An FY, Dholpe V, Ramamoorthy A, Lopatin DE, Lantz MS. 2007. The spectrum of antimicrobial activity of the bacteriocin subtilosin A. J Antimicrob Chemother. 59(2):297–300.
   PubMed Web of Science ®Google Scholar
• Silley P. 2006. Do bacteria need to be regulated? J Appl Microbiol. 101(3):607–615.
   PubMed Web of Science ®Google Scholar
• Simmonds RS, Pearson L, Kennedy RC, Tagg JR. 1996. Mode of action of a lysostaphin-like bacteriolytic agent produced by Streptococcus zooepidemicus 4881. Appl Environ Microbiol. 62(12):4536–4541.
   PubMed Web of Science ®Google Scholar
• Sorokulova IB, Beliavskaia VA, Masycheva VA, Smirnov VV. 1997. Recombinant probiotics: problems and prospects of their use for medicine and veterinary practice. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. 3:46–49.
   PubMedGoogle Scholar
• Sorokulova IB, Pinchuk IV, Denayrolles M, Osipova IG, Huang JM, Cutting SM, Urdaci MC. 2008. The safety of two Bacillus probiotic strains for human use. Dig Dis Sci. 53(4):954–963.
   PubMed Web of Science ®Google Scholar
• Sorokulova IB, Reva ON, Smirnov VV, Pinchuk IV, Lapa SV, Urdaci MC. 2003. Genetic diversity and involvement in bread spoilage of Bacillus strains isolated from flour and ropy bread. Lett Appl Microbiol. 37(2):169–173.
   PubMed Web of Science ®Google Scholar
• Sorokulova IB. 1998. The safety and reactogenicity of the new probiotic subalin for volunteers. Microbiol Z. 60:43–46.
   Google Scholar
• Spencer RC. 2003. Bacillus anthracis. J Clin Pathol. 56(3):182–187.
   PubMed Web of Science ®Google Scholar
• Stein T. 2005. Bacillus subtilis antibiotics: structures, syntheses and specific functions. Mol Microbiol. 56(4):845–857.
   PubMed Web of Science ®Google Scholar
• Suva Manoj A, Sureja Varun P, Kheni DB. 2016. Novel insight on probiotic Bacillus subtilis: Mechanism of action and clinical applications. J Curr Res Sci Med. 2(2):65–72.
   Google Scholar
• Suvorov A. 2020. What is wrong with enterococcal probiotics? Probiotics Antimicrob Proteins. 12(1):1–4.
   PubMed Web of Science ®Google Scholar
• Takano H. 2016. The regulatory mechanism underlying light-inducible production of carotenoids in nonphototrophic bacteria. Biosci Biotechnol Biochem. 80(7):1264–1273.
   PubMed Web of Science ®Google Scholar
• Tam NK, Uyen NQ, Hong HA, Duc Le H, Hoa TT, Serra CR, Henriques AO, Cutting SM. 2006. The intestinal life cycle of Bacillus subtilis and close relatives. J Bacteriol. 188(7):2692–2700.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Takanaka S, Yoshida K-I. 2014. A second-generation Bacillus cell factory for rare inositol production. Bioengineered. 5(5):331–334.
   PubMed Web of Science ®Google Scholar
• Taras D, Vahjen W, Macha M, Simon O. 2005. Response of performance characteristics and fecal consistency to long-lasting dietary supplementation with the probiotic strain Bacillus cereus var. toyoi to sows and piglets. Arch Anim Nutr. 59(6):405–417.
   PubMed Web of Science ®Google Scholar
• Taylor JM, Sutherland AD, Aidoo KE, Logan NA. 2005. Heat-stable toxin production by strains of Bacillus cereus, Bacillus firmus, Bacillus megaterium, Bacillus simplex and Bacillus licheniformis. FEMS Microbiol Lett. 242(2):313–317.
   PubMed Web of Science ®Google Scholar
• The Customs Union Safety Regulations on Food Safety. 2011. Approved on December 9, 2011 by the Decision of the Custom Union Commission, Document № 880 [accessed 2021 Apr 9]. http://www.tsouz.ru/db/techreglam/Documents/TR%20TS%20PishevayaProd.pdf.
   Google Scholar
• Umu ÖC, Bäuerl C, Oostindjer M, Pope PB, Hernández PE, Pérez-Martínez G, Diep DB. 2016. The potential of class II bacteriocins to modify gut microbiota to improve host health. PLOS One. 11(10):e0164036.
   PubMed Web of Science ®Google Scholar
• Vaseeharan B, Ramasamy P. 2003. Control of pathogenic Vibrio spp. by Bacillus subtilis BT23, a possible probiotic treatment for black tiger shrimp Penaeus monodon. Lett Appl Microbiol. 36(2):83–87.
   PubMed Web of Science ®Google Scholar
• Verdugo-Fuentes A, Gastélum G, Rocha J, de la Torre M. 2020. Multiple and overlapping functions of quorum sensing proteins for cell specialization in Bacillus species. J Bacteriol. 202(10):e00721-19.
   PubMed Web of Science ®Google Scholar
• Vreeland RH, Rosenzweig WD, Powers DW. 2000. Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal. Nature. 407(6806):897–900.
   PubMed Web of Science ®Google Scholar
• Wild MB, Marengoni NG, Vivian MMPS, Tsutsumi CY, Moura MC. 2014. Probiótico dietético em sistemas de produção de tilápia do Nilo: efeitos sobre o crescimento, balanço de N e P, retenção de nutrientes e viabilidade econômica. Sem Ci Agr. 35(1):477–490.
   Google Scholar
• Yang HJ, Kwon DY, Kim HJ, Kim MJ, Jung DY, Kang HJ, Kim DS, Kang S, Moon NR, Shin BK, et al. 2015. Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer’s type dementia. Eur J Nutr. 54(1):77–88.
   PubMed Web of Science ®Google Scholar
• Zhao C, Lv X, Fu J, He C, Hua H, Yan Z. 2016. In vitro inhibitory activity of probiotic products against oral Candida species. J Appl Microbiol. 121(1):254–262.
   PubMed Web of Science ®Google Scholar
• Zheng LP, Zou T, Ma YJ, Wang JW, Zhang YQ. 2016. Antioxidant and DNA damage protecting activity of exopolysaccharides from the endophytic bacterium Bacillus cereus SZ1. Molecules. 21(2):174.
   PubMed Web of Science ®Google Scholar
• Zhou ZW, Xia HM, Hu XC, Huang Y, Li YW, Li L, Ma C, Chen X, Hu F, Xu J, et al. 2008. Oral administration of a Bacillus subtilis spore-based vaccine expressing Clonorchis sinensis tegumental protein 22.3 kDa confers protection against Clonorchis sinensis. Vaccine. 26(15):1817–1825.
   PubMed Web of Science ®Google Scholar
• Zhu K, Hölzel CS, Cui Y, Mayer R, Wang Y, Dietrich R, Didier A, Bassitta R, Märtlbauer E, Ding S. 2016. Probiotic Bacillus cereus strains, a potential risk for public health in China. Front Microbiol. 7:718.
   PubMed Web of Science ®Google Scholar
• Zouari R, Hamden K, Feki AE, Chaabouni K, Makni-Ayadi F, Kallel C, Sallemi F, Ellouze-Chaabouni S, Ghribi-Aydi D. 2016. Protective and curative effects of Bacillus subtilis SPB1 biosurfactant on high-fat-high-fructose diet induced hyperlipidemia, hypertriglyceridemia and deterioration of liver function in rats. Biomed Pharmacother. 84:323–329.
   PubMed Web of Science ®Google Scholar