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Review Articles

The microbiome and precision oncology: an emerging paradigm in anticancer therapy

, ORCID Icon, ORCID Icon & ORCID Icon
Pages 770-783 | Received 31 Jul 2020, Accepted 25 Jan 2022, Published online: 15 Feb 2022

References

  • Author. 2010. Human genome at ten: the sequence explosion. Nature. 464(7289):670–671.
  • Alizadeh AA, Aranda V, Bardelli A, Blanpain C, Bock C, Borowski C, Caldas C, Califano A, Doherty M, Elsner M, et al. 2015. Toward understanding and exploiting tumor heterogeneity. Nat Med. 21(8):846–853.
  • Aragón IM, Herrera-Imbroda B, Queipo-Ortuño MI, Castillo E, Del Moral JS-G, Gómez-Millán J, Yucel G, Lara MF. 2018. The Urinary Tract Microbiome in health and disease. Eur Urol Focus. 4(1):128–138.
  • Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim JI, Shadaloey SA, Wu D, Preiss P, Verma N, et al. 2019. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 574(7777):264–267.
  • Azzam EI, Little JB. 2004. The radiation-induced bystander effect: evidence and significance. Hum Exp Toxicol. 23(2):61–65.
  • Baird JR, Friedman D, Cottam B, Dubensky TW, Kanne DB, Bambina S, Bahjat K, Crittenden MR, Gough MJ. 2016. Radiotherapy combined with Novel STING-targeting oligonucleotides results in regression of established tumors. Cancer Res. 76(1):50–61.
  • Barker HE, Paget JTE, Khan AA, Harrington KJ. 2015. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 15(7):409–425.
  • Bindels LB, Delzenne NM. 2013. Muscle wasting: the gut microbiota as a new therapeutic target? Int J Biochem Cell Biol. 45(10):2186–2190.
  • Blaser MJ. 2008. Understanding microbe-induced cancers. Cancer Prev Res. 1(1):15–20.
  • Bogenrieder T, Herlyn M. 2003. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene. 22(42):6524–6536.
  • Brandi G, Dabard J, Raibaud P, Di Battista M, Bridonneau C, Pisi AM, Morselli Labate AM, Pantaleo MA, De Vivo A, Biasco G, et al. 2006. Intestinal microflora and digestive toxicity of irinotecan in mice. Clin Cancer Res. 12(4):1299–1307.
  • Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T, et al. 2005. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 434(7035):913–917.
  • Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI. 2009. Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem. 16(25):3267–3285.
  • Chang M-H, Chen C-J, Lai M-S, Hsu H-M, Wu T-C, Kong M-S, Liang D-C, Shau W-Y, Chen D-S. 1997. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med. 336(26):1855–1859.
  • Ciorba MA, Riehl TE, Rao MS, Moon C, Ee X, Nava GM, Walker MR, Marinshaw JM, Stappenbeck TS, Stenson WF, et al. 2012. Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner. Gut. 61(6):829–838.
  • Cramer P, Bresalier RS. 2017. Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors. Curr Gastroenterol Rep. 19(1):3.
  • Crawford PA, Gordon JI. 2005. Microbial regulation of intestinal radiosensitivity. Proc Natl Acad Sci USA. 102(37):13254–13259.
  • Cui M, Xiao H, Li Y, Zhou L, Zhao S, Luo D, Zheng Q, Dong J, Zhao Y, Zhang X, et al. 2017. Faecal microbiota transplantation protects against radiation-induced toxicity. EMBO Mol Med. 9(4):448–461.
  • Cyranoski D. 2016. CRISPR gene-editing tested in a person for the first time. Nature. 539(7630):479.
  • Daillere R, Vetizou M, et al. 2016. Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 45(4):931–943.
  • Dasgupta S, Erturk-Hasdemir D, Ochoa-Reparaz J, Reinecker H-C, Kasper DL. 2014. Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe. 15(4):413–423.
  • David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al. 2014. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 505(7484):559–563.
  • de Klerk N, Maudsdotter L, Gebreegziabher H, Saroj SD, Eriksson B, Eriksson OS, Roos S, Lindén S, Sjölinder H, Jonsson A-B, et al. 2016. Lactobacilli reduce Helicobacter pylori attachment to host gastric epithelial cells by inhibiting adhesion gene expression. Infect Immun. 84(5):1526–1535.
  • Delia P, Sansotta G, et al. 2007. Use of probiotics for prevention of radiation-induced diarrhea. World J Gastroenterol. 13(6):912–915.
  • Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, Formenti SC. 2004. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 58(3):862–870.
  • Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu Y-X. 2014. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 124(2):687–695.
  • Derer A, Deloch L, Rubner Y, Fietkau R, Frey B, Gaipl US. 2015. Radio-Immunotherapy-induced immunogenic cancer cells as basis for induction of systemic anti-tumor immune responses - pre-clinical evidence and ongoing clinical applications. Front Immunol. 6:505.
  • Do K, O’Sullivan Coyne G, et al. 2015. An overview of the NCI precision medicine trials-NCI MATCH and MPACT. Chin Clin Oncol. 4(3):31.
  • Donaldson GP, Lee SM, Mazmanian SK. 2016. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol. 14(1):20–32.
  • Dubin K, Callahan MK, Ren B, Khanin R, Viale A, Ling L, No D, Gobourne A, Littmann E, Huttenhower C, et al. 2016. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun. 7:10391.
  • ElRakaiby M, Dutilh BE, Rizkallah MR, Boleij A, Cole JN, Aziz RK. 2014. Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics. Omics. 18(7):402–414.
  • Faust K, Lahti L, Gonze D, de Vos WM, Raes J. 2015. Metagenomics meets time series analysis: unraveling microbial community dynamics. Curr Opin Microbiol. 25:56–66.
  • Ferreira MR, Muls A, Dearnaley DP, Andreyev HJN. 2014. Microbiota and radiation-induced bowel toxicity: lessons from inflammatory bowel disease for the radiation oncologist. Lancet Oncol. 15(3):e139-147–e147.
  • Flemer B, Lynch DB, Brown JMR, Jeffery IB, Ryan FJ, Claesson MJ, O’Riordain M, Shanahan F, O’Toole PW. 2017. Tumour-associated and non-tumour-associated microbiota in colorectal cancer. Gut. 66(4):633–643.
  • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O’Connor MJ, et al. 2009. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 361(2):123–134.
  • Foster KR, Schluter J, Coyte KZ, Rakoff-Nahoum S. 2017. The evolution of the host microbiome as an ecosystem on a leash. Nature. 548(7665):43–51.
  • Franzosa EA, Huang K, Meadow JF, Gevers D, Lemon KP, Bohannan BJM, Huttenhower C. 2015. Identifying personal microbiomes using metagenomic codes. Proc Natl Acad Sci USA. 112(22):E2930–2938.
  • Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, et al. 2017. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 357(6356):1156–1160.
  • Genton L, Mareschal J, Charretier Y, Lazarevic V, Bindels LB, Schrenzel J. 2019. Targeting the gut microbiota to treat Cachexia. Front Cell Infect Microbiol. 9:305.
  • Gerlinger M, Swanton C. 2010. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Br J Cancer. 103(8):1139–1143.
  • Ginsburg GS. 2013. Realizing the opportunities of genomics in health care. JAMA. 309(14):1463–1464.
  • Gonzalez H, Hagerling C, Werb Z. 2018. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 32(19-20):1267–1284.
  • Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, et al. 2018. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 359(6371):97–103.
  • Green JM, Barratt MJ, Kinch M, Gordon JI. 2017. Food and microbiota in the FDA regulatory framework. Science. 357(6346):39–40.
  • Grootaert C, Van de Wiele T, Van Roosbroeck I, Possemiers S, Vercoutter-Edouart A-S, Verstraete W, Bracke M, Vanhoecke B. 2011. Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines. Environ Microbiol. 13(7):1778–1789.
  • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. 2005. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res. 65(8):3437–3446.
  • He Y, Fu L, Li Y, Wang W, Gong M, Zhang J, Dong X, Huang J, Wang Q, Mackay CR, et al. 2021. Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8(+) T cell immunity. Cell Metab. 33(5):988–1000.e7.
  • Herremans KM, Riner AN, Cameron ME, Trevino JG. 2019. The microbiota and cancer cachexia. Int J Mol Sci. 20(24):6267.
  • Heshiki Y, Vazquez-Uribe R, Li J, Ni Y, Quainoo S, Imamovic L, Li J, Sørensen M, Chow BKC, Weiss GJ, et al. 2020. Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome. 8(1):28.
  • Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, et al. 2013. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 342(6161):967–970.
  • Jones RM, Desai C, Darby TM, Luo L, Wolfarth AA, Scharer CD, Ardita CS, Reedy AR, Keebaugh ES, Neish AS, et al. 2015. Lactobacilli modulate epithelial cytoprotection through the Nrf2 Pathway. Cell Rep. 12(8):1217–1225.
  • Jones RM, Luo L, Ardita CS, Richardson AN, Kwon YM, Mercante JW, Alam A, Gates CL, Wu H, Swanson PA, et al. 2013. Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species. Embo J. 32(23):3017–3028.
  • Klein GL, Petschow BW, Shaw AL, Weaver E. 2013. Gut barrier dysfunction and microbial translocation in cancer cachexia: a new therapeutic target. Curr Opin Support Palliat Care. 7(4):361–367.
  • Krishnan K, Chen T, Paster BJ. 2017. A practical guide to the oral microbiome and its relation to health and disease. Oral Dis. 23(3):276–286.
  • Kroemer G, Galluzzi L, Kepp O, Zitvogel L. 2013. Immunogenic cell death in cancer therapy. Annu Rev Immunol. 31:51–72.
  • Lax AJ, Thomas W. 2002. How bacteria could cause cancer: one step at a time. Trends Microbiol. 10(6):293–299.
  • Lee H, Lee Y, Kim J, An J, Lee S, Kong H, Song Y, Lee C-K, Kim K. 2018. Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice. Gut Microbes. 9(2):155–165.
  • Lin XB, Dieleman LA, Ketabi A, Bibova I, Sawyer MB, Xue H, Field CJ, Baracos VE, Gänzle MG. 2012. Irinotecan (CPT-11) chemotherapy alters intestinal microbiota in tumour bearing rats. PLoS One. 7(7):e39764.
  • Longley DB, Harkin DP, Johnston PG. 2003. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 3(5):330–338.
  • Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre M-L, Luke JJ, Gajewski TF. 2018. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 359(6371):104–108.
  • Mitra A, Grossman Biegert GW, Delgado AY, Karpinets TV, Solley TN, Mezzari MP, Yoshida-Court K, Petrosino JF, Mikkelson MD, Lin L, et al. 2020. Microbial diversity and composition is associated with patient-reported toxicity during chemoradiation therapy for cervical cancer. Int J Radiat Oncol Biol Phys. 107(1):163–171.
  • Moffatt MF, Cookson WO. 2017. The lung microbiome in health and disease. Clin Med. 17(6):525–529.
  • Mullard A. 2015. NCI-MATCH trial pushes cancer umbrella trial paradigm. Nat Rev Drug Discov. 14(8):513–515.
  • Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, et al. 2020. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science. 368(6494):973–980.
  • Nigro G, Rossi R, Commere P-H, Jay P, Sansonetti PJ. 2014. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe. 15(6):792–798.
  • Oliva M, Mulet-Margalef N, Ochoa-De-Olza M, Napoli S, Mas J, Laquente B, Alemany L, Duell E, Nuciforo P, Moreno V, et al. 2021. Tumor-associated microbiome: where do we stand? IJMS. 22(3):1446.
  • Ó Broin P, Vaitheesvaran B, Saha S, Hartil K, Chen EI, Goldman D, Fleming WH, Kurland IJ, Guha C, Golden A, et al. 2015. Intestinal microbiota-derived metabolomic blood plasma markers for prior radiation injury. Int J Radiat Oncol Biol Phys. 91(2):360–367.
  • Parsonnet J. 1995. Bacterial infection as a cause of cancer. Environ Health Perspect. 103 Suppl 8 (Suppl 8):263–268.
  • Peek RM, Jr., Blaser MJ. 2002. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2(1):28–37.
  • Pitt JM, Vétizou M, Waldschmitt N, Kroemer G, Chamaillard M, Boneca IG, Zitvogel L. 2016. Fine-tuning cancer immunotherapy: optimizing the gut microbiome. Cancer Res. 76(16):4602–4607.
  • Pitt JM, Vétizou M, Daillère R, Roberti MP, Yamazaki T, Routy B, Lepage P, Boneca IG, Chamaillard M, Kroemer G, et al. 2016. Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors. Immunity. 44(6):1255–1269.
  • Ramirez-Garcia A, Rementeria A, Aguirre-Urizar JM, Moragues MD, Antoran A, Pellon A, Abad-Diaz-de-Cerio A, Hernando FL. 2016. Candida albicans and cancer: can this yeast induce cancer development or progression? Crit Rev Microbiol. 42(2):181–193.
  • Ramirez-Garcia A, Arteta B, Abad-Diaz-de-Cerio A, Pellon A, Antoran A, Marquez J, Rementeria A, Hernando FL. 2013. Candida albicans increases tumor cell adhesion to endothelial cells in vitro: intraspecific differences and importance of the mannose receptor. PloS One. 8(1):e53584.
  • Rautio J, Kumpulainen H, Heimbach T, Oliyai R, Oh D, Järvinen T, Savolainen J. 2008. Prodrugs: design and clinical applications. Nat Rev Drug Discov. 7(3):255–270.
  • Rigby RJ, Carr J, Orgel K, King SL, Lund PK, Dekaney CM. 2016. Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut Microbes. 7(5):414–423.
  • Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR. 2013. Molecular insights into microbial beta-glucuronidase inhibition to abrogate CPT-11 toxicity. Mol Pharmacol. 84(2):208–217.
  • Rolston KV. 2017. Infections in cancer patients with solid tumors: a review. Infect Dis Ther. 6(1):69–83.
  • Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al. 2018. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359(6371):91–97.
  • Saltz LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, Maroun JA, Ackland SP, Locker PK, Pirotta N, et al. 2000. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med. 343(13):905–914.
  • Saussele S, Krauss M-P, Hehlmann R, Lauseker M, Proetel U, Kalmanti L, Hanfstein B, Fabarius A, Kraemer D, Berdel WE, et al. 2015. Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML study IV. Blood. 126(1):42–49.
  • Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. 2007. Human papillomavirus and cervical cancer. Lancet. 370(9590):890–907.
  • Sender R, Fuchs S, Milo R. 2016. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 164(3):337–340.
  • Sharma A, Rath GK, Chaudhary SP, Thakar A, Mohanti BK, Bahadur S. 2012. Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer: a randomized double-blind placebo-controlled study. Eur J Cancer. 48(6):875–881.
  • Sharma P, Allison JP. 2015. The future of immune checkpoint therapy. Science. 348(6230):56–61.
  • Sheflin AM, Whitney AK, Weir TL. 2014. Cancer-promoting effects of microbial dysbiosis. Curr Oncol Rep. 16(10):406.
  • Shin SH, Bode AM, Dong Z. 2017. Precision medicine: the foundation of future cancer therapeutics. NPJ Precis Oncol. 1(1):12.
  • Si W, Liang H, Bugno J, Xu Q, Ding X, Yang K, Fu Y, Weichselbaum RR, Zhao X, Wang L, et al. 2021. Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade. Gut. 2021:gutjnl-2020-323426.
  • Siegel RL, Miller KD, Jemal A. 2020. Cancer statistics, 2020. CA A Cancer J Clin. 70(1):7–30.
  • Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre M-L, et al. 2015. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 350(6264):1084–1089.
  • Sousa T, Paterson R, Moore V, Carlsson A, Abrahamsson B, Basit AW. 2008. The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm. 363(1–2):1–25.
  • Stewart CA, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, Leighty RM, Roers A, Karp CL, Müller W, et al. 2013. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest. 123(11):4859–4874.
  • Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh ASJ, Hamilton J, Keefe DMK. 2009. Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis. Exp Biol Med. 234(4):430–441.
  • Stringer AM, Gibson RJ, Bowen JM, Logan RM, Ashton K, Yeoh ASJ, Al-Dasooqi N, Keefe DMK. 2009. Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile. Int J Exp Pathol. 90(5):489–499.
  • Sun Y-Z, Zhang D-H, Cai S-B, Ming Z, Li J-Q, Chen X. 2018. MDAD: a special resource for microbe-drug associations. Front Cell Infect Microbiol. 8:424.
  • Testa MM, Ruiz de Valladares R, Benito de Cardenas IL. 2003. Antagonistic interactions among Fusobacterium nucleatum and Prevotella intermedia with oral lactobacilli. Res Microbiol. 154(10):669–675.
  • Thomas T, Gilbert J, Meyer F. 2012. Metagenomics – a guide from sampling to data analysis. Microb Inform Exp. 2(1):3.
  • Touchefeu Y, Montassier E, Nieman K, Gastinne T, Potel G, Bruley Des Varannes S, Le Vacon F, de La Cochetière MF. 2014. Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis – current evidence and potential clinical applications. Aliment Pharmacol Ther. 40(5):409–421.
  • Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. 2007. The human microbiome project. Nature. 449(7164):804–810.
  • Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, et al. 2020. Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response. J Clin Invest. 130(1):466–479.
  • van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JFWM, Tijssen JGP, et al. 2013. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 368(5):407–415.
  • Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh D-Y, Diéras V, Guardino E, et al. 2012. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 367(19):1783–1791.
  • Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CPM, et al. 2015. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 350(6264):1079–1084.
  • Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, et al. 2013. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 342(6161):971–976.
  • Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh L-A, Mani S, et al. 2010. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 330(6005):831–835.
  • Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R. 2013. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell. 153(4):910–918.
  • Wu J, Li Q, Fu X. 2019. Fusobacterium nucleatum contributes to the carcinogenesis of colorectal cancer by inducing inflammation and suppressing host immunity. Transl Oncol. 12(6):846–851.
  • Wu S, Zhu W, Thompson P, Hannun YA. 2018. Evaluating intrinsic and non-intrinsic cancer risk factors. Nat Commun. 9(1):3490.
  • Yamamura K, Baba Y, Miyake K, Nakamura K, Shigaki H, Mima K, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, et al. 2017. Fusobacterium nucleatum in gastroenterological cancer: evaluation of measurement methods using quantitative polymerase chain reaction and a literature review. Oncol Lett. 14(6):6373–6378.
  • Yeh K-Y, Wang H-M, Chang JW-C, Huang J-S, Lai C-H, Lan Y-J, Wu T-H, Chang P-H, Wang H, Wu C-J, et al. 2013. Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 116(1):41–48.
  • Yi SY, Park YS, Kim HS, Jun HJ, Kim KH, Chang MH, Park MJ, Uhm JE, Lee J, Park SH, et al. 2009. Irinotecan monotherapy as second-line treatment in advanced pancreatic cancer. Cancer Chemother Pharmacol. 63(6):1141–1145.
  • Yu T, Guo F, Yu Y, Sun T, Ma D, Han J, Qian Y, Kryczek I, Sun D, Nagarsheth N, et al. 2017. Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell. 170(3):548–563 e516.
  • Zhang X, Li L, Butcher J, Stintzi A, Figeys D. 2019. Advancing functional and translational microbiome research using meta-omics approaches. Microbiome. 7(1):154.
  • Zhao Z, Cheng W, Qu W, Shao G, Liu S. 2020. Antibiotic alleviates radiation-induced intestinal injury by remodeling microbiota, reducing inflammation, and inhibiting fibrosis. ACS Omega. 5(6):2967–2977.
  • Zitvogel L, Daillère R, Roberti MP, Routy B, Kroemer G. 2017. Anticancer effects of the microbiome and its products. Nat Rev Microbiol. 15(8):465–478.
  • Zou Y, Xue W, Luo G, Deng Z, Qin P, Guo R, Sun H, Xia Y, Liang S, Dai Y, et al. 2019. 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses. Nat Biotechnol. 37(2):179–185.

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