Aromatic Amines in Experimental Cancer Research: Tissue-Specific Effects, an Old Problem and New Solutions

REFERENCES

• Arai M., Yokosuka O., Fukai K., Imazeki F., Chiba T., Sumi H., Kato M., Tagiguchi M., Saisho H., Muramatsu M., Seki N. Gene expression profiles in liver regeneration with oval cell induction. Biochem. Biophys. Res. Commun 2004; 317: 370–376
   PubMed Web of Science ®Google Scholar
• Bannasch P., Hesse J., Angerer H. Hepatozelluläre Glykogenosen und die Genese sogenannter hyperplastischer Knoten in der Thioacetamid-vergifteten Rattenleber. Virchows Arch B Cell. Pathol 1974; 17(29)50
   Google Scholar
• Bannasch P., Papenburg J., Ross W. Cytomorphologische und morphometrische Studien der Hepatocarcinogenese. Z. Krebsforsch 1972; 77: 108–133
   Google Scholar
• Bannasch P., Reiss W. Histogenese und Cytogenese cholangiocellulärer Tumoren bei Nitrosomorpholin-vergifteten Ratten. Zugleich ein Beitrag zur Morphogenese der Cystenleber. Z. Krebsforsch 1971; 76: 193–215
   Google Scholar
• Bauer K. H. Das Krebsproblem. 2. Auflage, Springer Verlag OHG, Berlin, Heidelberg 1963
   Google Scholar
• Baur H., Neumann H. G. Correlation of nucleic acid binding by metabolites of trans-4-aminostilbene derivatives with tissue specific acute toxicity and carcinogenicity in rats. Carcinogenesis 1980; 1: 877–855
   PubMed Web of Science ®Google Scholar
• Beland F. A., Fullerton N. F., Kinouchi T., Smith B. A., Poirier M. C. DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene. In:. Mouse Liver Carcinogenesis: Mechanisms and Species Comparison. Alan R. Liss, New York 1990; 121–129
   Google Scholar
• Berenblum I. Arch. Pathol 1944; 38: 233
   Google Scholar
• Berenblum I. Some new implications of the two-stage mechanism in the study of skin carcinogenesis. G.E.W. Wolstenholm, O'Conner M. Cf. Ciba Foundation Symposium, Churchill Ltd., London 1959
   Google Scholar
• Berenblum I., Shubik P. The role of croton oil applications, associated with a single painting of a carcinogen, in tumor induction of the mouse's skin. Br. J. Cancer 1947; 1: 379–382
   PubMed Web of Science ®Google Scholar
• Berenblum I., Vlasta A. Two independent aspects of tumor promotion. Biochim. Biophys Acta 1981; 651: 51–63
   PubMed Web of Science ®Google Scholar
• Bergmann E. D., Pullman B. Physico-chemical mechanisms of carcinogenesis, The Jerusalem Symposia on quantum chemistry and biochemistry. The Israel Academy of Sciences and Humanities. Jerusalem. 1969
   Google Scholar
• Bielschowsky F. Br. J. Exp. Pathol 1944; 25: 90
   Google Scholar
• Birnboim H. C. Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. Can. J. Physiol. Pharmacol 1982; 60: 1359–1366
   PubMed Web of Science ®Google Scholar
• Bitsch A., Fecher M., Jost M., Klöhn P. C., Neumann H. G. Genotoxic and chronic toxic effects in the carcinogenicity of aromatic amines. Recent Results Cancer Res. 1997; 143: 209–223
   PubMedGoogle Scholar
• Bitsch A., Hadjiolov N., Klöhn P. C., Bergmann O., Zwirner-Baier I., Neumann H. G. Dose response of early effects related to tumor promotion of 2-acetylaminofluorene. Toxicol. Sci. 2000; 55: 44–51
   PubMed Web of Science ®Google Scholar
• Bitsch A., Röschlau H. Deubelbeiss, Neumann H. G. The structure and function of the H-ras proto-oncogene are not altered in rat liver tumors initiated by 2-acetylaminofluorene, 2-acetylaminophenanthrene and trans-4-acetylaminostilbene. Toxicol. Lett. 1993; 67: 173–186
   PubMed Web of Science ®Google Scholar
• Blanck A., Wicksell. L., Erriksson L. C. Sulfation of N-hydroxy-2-acetylaminofluorene in normal and nodular liver from male Wistar rats. Toxicol. Pathol 1987; 13: 103–105
   Google Scholar
• Boutwell R. K. Some biological aspects of skin carcinogenesis. Prog. Exp. Tumor Res. 1964; 19: 207–250
   Google Scholar
• Cairns J. The origin of human cancer. Nature 1981; 289: 353–357
   PubMed Web of Science ®Google Scholar
• Cameron R., Farber E. Some conclusions derived from a liver model for carcinogenesis. Proceedings of an international conference: Carcinogenic and mutagenic N-substituted aryl compounds. National Cancer Institute Monograph 1979; 58: 49–53, NIH Publiction No 81-2379.(1981)
   Google Scholar
• Columbano A., Ledda-Columbano G.M., Coni P., Ennas M., Sarma D. S.R., Pani P. Can apoptosis influence initiation of chemical hepatocarcinogenesis. In:. Chemical Carcinogenesis, Models and Mechanisms, Feo F., Pani P., Columbano A., Garcea R. Plenum Press, New York 1988; 281–292
   Google Scholar
• Cox A. J., Wilson R. H., DeEds F. The carcinogenic activity of 2-acetaminfluorene, characteristics of the lesions in albino rats. Cancer Res 1947; 5: 647–657
   Google Scholar
• Cramer J. W., Miller J. A., Miller E. K. NHydroxylation: A new metabolic reaction observed in the rat with the carcinogen 2-acetylaminofluorene. J. Biol. Chem. 1960; 235: 885–888
   PubMed Web of Science ®Google Scholar
• Custer R. P., Sorof S. Target polypeptide of a carcinogen is associated with normal mitosis and carcinogen-induced hyperplasia in adult hepatocytes. Proc. Natl. Acad. Sci. USA 1984; 81: 6738–6742
   PubMed Web of Science ®Google Scholar
• Druckrey H. Pharmacological approach to carcinogenesis. In:. Ciba Foundation Symposium on Carcinogenesis, Mechanisms of Action, Wolstenholmand G.E.W., O'Connor M. Churchill, London 1959; 110–130
   Google Scholar
• Druckrey H., Schmähl D., Dischler W. Dosis-Wirkungs-Beziehungen bei der Krebserzeugung durch 4-Dimethylaminostilben bei Ratten. Z. Krebsforsch 1963; 65: 272–288
   Google Scholar
• Enzmann H., Bannasch P. Non-persisting early foci of altered hepatocytes induced in rats with N-nitrosomorpholine. J. Cancer Res. Clin. Oncol 1988; 114: 30–34
   PubMed Web of Science ®Google Scholar
• Erikson L. C., Andersson G. N. Membrane biochemistry and chemical hepatocacinogenesis. Crit. Rev. Biochem. Mol. Biol. 1992; 27: 1–55
   PubMed Web of Science ®Google Scholar
• Eriksson L. C., Rinaudo J. A., Farber E. Kinetics of interaction of 2-acetylaminofluorene with normal and carcinogen-induced hepatocyte nodules in vivo and in vitro. Lab. Invest 1989; 60: 409–417
   PubMed Web of Science ®Google Scholar
• Euler H. von, Skarzinski B. Biochemie der Tumoren. Ferdinand Enke Verlag, Stuttgart 1942
   Google Scholar
• Farber E. Similarities in the sequence of early histological changes induced in livers of rats by ethionin, 2-acetylaminofluorene and 3′methyl-4-dimethylaminoazobenzene. Cancer Res. 1956; 16: 142–148
   PubMed Web of Science ®Google Scholar
• Farber E. Carcinogenesis: cellular evolution as a unifying thread: Presidential address. Cancer Res 1973; 33: 2537–2550
   PubMed Web of Science ®Google Scholar
• Farber E. Initiators, Promoters and the uncertainty principle. Tumor Biol 1988; 9: 165–169
   PubMedGoogle Scholar
• Farber E. Clonal adaptation during carcinogenesis, Commentary. Biochem. Pharmacol. 1990; 39: 1837–1846
   PubMed Web of Science ®Google Scholar
• Farber E. Is carcinogenesis fundamentally adversarial-confrontational or physiological adaptive. J. Invest. Dermatol. 1993; 100: 251–253
   PubMed Web of Science ®Google Scholar
• Farber E. Cell proliferation as a major risk factor for cancer: A concept of doubtful validity. Cancer Res 1995; 55: 3759–3762
   PubMed Web of Science ®Google Scholar
• Farber E. Risk assessment for possible carcinogens: A critical look. Drug Metab. Rev. 2000; 32: 143–151
   PubMed Web of Science ®Google Scholar
• Farber E. Gap-junction communication in chemical carcinogenesis; Response:. Drug Metab. Rev. 2001; 33: 123–124
   Web of Science ®Google Scholar
• Farber E., Rotstein J., Harris L., Lee G., Chen Z. Y. Cell proliferation and cell loss in progression in liver carcinogenesis: A new hypothesis. In:. Chemical Carcinogenesis, Models and Mechanisms, Feo F., Pani P., Columbano A., Garcea R. Plenum Press, New York 1988; 167–172
   Google Scholar
• Farber E., Rubin H. Cellular adaptation in the origin of cancer. Cancer Res 1991; 51: 2751–2761
   PubMed Web of Science ®Google Scholar
• Faustman-Watts E. M., Yang H. Y.L., Namkung M., Greenaway J. C., Fantel A. G., Juchau M. R. Mutagenic, cytotoxic, and teratogenic effects of 2-acetylaminofluorene and reactive metabolites in vitro. Teratogen. Carcinogen. Mutagen 1984; 4: 273–283
   PubMedGoogle Scholar
• Firminger J. C. J. Natl. Cancer Inst 1955; 15: 1427
   PubMed Web of Science ®Google Scholar
• Flaks B. Changes in the fine structure of rat hepaocytes during the early phases of chronic 2-acetylaminofluorene intoxication. Chem. Biol. Interact. 1970; 2: 129–150
   PubMedGoogle Scholar
• Flaks B. Early changes in the fine structure of rat hepatocytes induced by the non-carcinogen 4-acetylaminofluorene. Chem. Biol. Interact. 1972; 5: 127–137
   PubMed Web of Science ®Google Scholar
• Gastman B. R. Apoptosis and its clinical impact. Head Neck J. Sci. Special. Head Neck 2001; 23: 409–425
   PubMed Web of Science ®Google Scholar
• Glatt H. R., Oesch F. Activation of N-acetoxy-und N-hydroxy-2-acetylaminofluoren to mutagenic and cytotoxic metabolites by V79 Chinese hamster cells. Mutat. Res 1985; 149: 265–269
   PubMedGoogle Scholar
• Green D., Kroemer G. The central executioners of apoptosis: caspases or mitochondria. Trends Cell Biol. 1998; 8: 267–271
   PubMed Web of Science ®Google Scholar
• Green D., Reed J. C. Mitochondria and apoptosis. Science 1998; 281: 1309–1312
   PubMed Web of Science ®Google Scholar
• Haddow A. Cellular inhibition and the origin of cancer. Acta Unio Int. Contra Cancrum 1938; 3: 342–352
   Google Scholar
• Haddow A., Harris R. J.C., Kon G. A.R., Roe E. M.F. The growth inhibitory effect and carcinogenic properties of 4-aminostilbene and derivatives. Philos. Trans. R. Soc. Lond. 1948; 241: 147
   Google Scholar
• Hall W. H. Br. J. Cancer 1948; 2: 273
   PubMed Web of Science ®Google Scholar
• Hampton M. J., Floyd R. A., Clark J. B., Lancaster J. H. Binding and mutagenicity studies with 2-nitrosofluorene on Salmonella typhimurium TA 98 grown at different temperatures. Mutat. Res 1980; 69: 231–239
   PubMedGoogle Scholar
• Hanahan D., Weinberg R. A. The hallmarks of cancer. Cell 2000; 100: 57–70
   PubMed Web of Science ®Google Scholar
• Hecker E., Traut M., Hopp M. Über die karzinogene Wirkung von 3-Amino-delta-1,3.5(10)-östratrienen und von 2-Nitrosofluoren. Z. Krebsforsch 1968; 71: 81–88
   PubMedGoogle Scholar
• Heidelberger C. In: Ciba Foundation Symposium cf. Discussion S. Berenblum 1959; 192–196
   Google Scholar
• Hilpert D., Neumann H. G. Accumulation and elimination of macromolecular lesions in susceptible and non susceptible rat tissues after repeated administration of trans-4 acetylaminostilbene. Chem. Biol. Interact. 1985; 54: 85–96
   PubMed Web of Science ®Google Scholar
• Hilpert D., Romen W., Neumann H. G. The role of partial hepatectomy and of promoters in the formation of tumors in non-target tissues of trans-4-acetylaminostilben in rats. Carcinogenesis 1983; 1: 1519–1525
   Google Scholar
• Hoel D. G., Haseman J. K., Hogan M. D., McConnell E.E. The impact of toxicity on carcinogenicity studies: implications for risk assessment. Carcinogenesis 1988; 11: 2045–2052
   Google Scholar
• Hoffmann A., Romen W., Neumann H. G. Tumors in rat kidney with trans-4-acetylaiminostilben under several promoting treatments. J. Cancer Res. Clin. Oncol. 1993; 119: 329–334
   PubMed Web of Science ®Google Scholar
• Huitfeld H. S., Hunt J. M., Pitot, HC., Poirier M. C. Lack of acetylaminofluorene–DNA adduct formation in enzyme altered foci of rat liver. Carcinogenesis 1988; 9: 647–652
   PubMed Web of Science ®Google Scholar
• Jensen E. V., Jacobson H. I. Fate of steroid estrogens in target tissues. In:. Biological Activities of Steroids in Relation to Cancer, Pincus G., Vollmer E.P. Academic Press, New York 1960; 161–178
   Google Scholar
• Jensen E.V., Jacobson H.I., Flesher J.W., Saha N.N., Gupta G.N., Smith S., Collucci V., Shipplacoff D., Neumann H.G., DeSombre E.R., Jungblut P.W. Estrogen resceptors in target tissues. In:. Steroid Dynamics. Academic Press, New York 1966; 133–157
   Google Scholar
• Kanduc D., Mittelman A., Serpico R., Sinigaglia E., Sinha A. A., Natale C., Santacroce R., Di Corcia M.G., Lucchese A., Dini L., Pani P., Santacroce S., Simone S., Bucchi R., Farber E. Cell death: Apoptosis versus necrosis (Review). Int. J. Oncol. 2002; 21: 165–170
   PubMed Web of Science ®Google Scholar
• Kaplan H. S. Discussion. In: Ciba Foundation Symposium on Carcinogenesis. Mechanisms of Action. J & A Churchill, London 1959; 193–194
   Google Scholar
• Kirschbaum A. The carcinogenic stimulus. In:. Fundamental Aspects of Normal and Malignant Growth, Nowinski W.W. Elsevier, New York 1960; 866
   Google Scholar
• Kitagawa T., Sugano H., Nakahara W, Hirayama T., Nishioka K., Sugano H. Timetable for hepatocarcinogenesis in rat. In:. Analytical and Experimental Epidemiology of Cancer. Proceedings of the third International Symposium of the Princess Takamatsu Cancer Research Fund. University Park Press, Tokyo 1973; 91–105
   Google Scholar
• Kitagawa T., Pitot H. C. The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide. Cancer Res 1975; 35: 1075–1084
   PubMed Web of Science ®Google Scholar
• Klöhn P. J., Massalha H., Neumann H. G. A metabolite ofcarcinogenic 2-acetylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria. Biochim. Biophys. Acta 1995; 1229: 363–372
   PubMed Web of Science ®Google Scholar
• Klöhn P. C. Die Rolle der Mitochondrien als Angriffspunkt für die nicht-gentoxische Wirkung des kompletten Kanzerogens 2-Acetylaminofluoren in der Rattenleber. Dissertation. Universität Würzburg. 1997
   Google Scholar
• Klöhn P. C., Bitsch A., Neumann H. G. Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene. Carcinogenesis 1998; 19: 1185–1190
   PubMed Web of Science ®Google Scholar
• Klöhn P. C., Brandt U., Neumann H. G. 2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complex. FEBS Lett. 1996; 389: 233–237
   PubMed Web of Science ®Google Scholar
• Klöhn P. C., Neumann H. G. Impairment of respiration and oxidative phosphorylation by redoxcyclers 2-nitrosofluorene and menadione. Chem. Biol., Interact. 1997; 106: 15–2
   PubMed Web of Science ®Google Scholar
• Klöhn P. C., Soriano M. E., Irwin W., Penzo D., Scorrano L., Bitsch A., Neumann H. G., Bernardi P. Early resistance to cell death and to the onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene. Proc. Natl. Acad. Sci. USA 2003; 100: 10014–10019
   PubMed Web of Science ®Google Scholar
• Koller P. C. J. Natl. Cancer Inst 1955; 15: 1237
   PubMedGoogle Scholar
• Kriek E. On the mechanism of action or aromatic amines in vivo–difference of binding to ribosomal RNA and DNA. In:. Physico-Chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, E.D. Bergmann, B. Pullman. Israel Academy of Sciences and Humanities, Jerusalem 1969; 139–138
   Google Scholar
• Kunz H. W., Buchmann A., Schwarz M., Schmitt R., Kuhlman W. D., Wolf C. R., Oesch F. Expression and inducibility of drug-metabolizing enzymes in preneoplastic and neoplastic lesions of rat liver during nitrosamine-induced hepatocarcinogenesis. Arch. Toxicol 1987; 60: 198–203
   PubMed Web of Science ®Google Scholar
• Kunz H. W., Schwarz M., Tennekes H., Port R., Appel K.E. Mechanisms and dose-time response characteristics of carcinogenic and tumor promoting xenobiotics in liver. In:. Tumorpromotoren, Appel K.E., Hildebrandt A.G. bga-Schriften 6/85 MMV-Verlag München 1985. 1985; 76–94
   Google Scholar
• Kunz HW., Tennekes H. A., Port R. E. Quantitative aspects of chemical carcinogenesis and tumor promotion in liver. Environ. Health Perspect 1983; 50: 113–123
   PubMed Web of Science ®Google Scholar
• Lafaurie M., Aussel C., Stora C., Krebs B. Modifications in adrenal activity during hepatocarcinogenesis by N-2-fluorenylacetamide. Steroids 1980; 35: 489–501
   PubMed Web of Science ®Google Scholar
• Lemmer E. R., Vessey C. J., Gelderblom W. C., Shepard E. G., Van Schall D.J., Van Weijk R.A., Mrasas W. F., Kirsch R. E., Hall P. P. Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: Potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. Carcinogenesis 2004; 25: 1257–1264
   PubMed Web of Science ®Google Scholar
• Lev-Ran A., Josefsberg Z., Carr B. I., Barseghian G., Hwang D. Effects of the hepatocarcinogen 2-acetylaminofluorene on insulin binding to microsomal and Golgi fractions of rat liver cells. J. Natl. Cancer Inst 1984; 73: 505–509
   PubMedGoogle Scholar
• Lown J. W., Joshua A. V., Chen H. H. Free Radicals, Lipid Peroxidation and Cancer. Academic Press, New York 1982; 305–328, Mc Brian, D.C.H., and Slater, T.F.
   Google Scholar
• Mignotte B., Vayssiere H. Mitochondria and apoptosis. Eur. J. Biochem. 1998; 252: 1–15
   PubMedGoogle Scholar
• Miller J. A., Miller E. C. Metabolic activation of carcinogenic aromatic amines and amides via N-hydroxylation and N-hydroxy-esterification and its relationship to ultimate carcinogens as electrophilic reactants. In:. Physico-Chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, E.D. Bergmann, B. Pullman. Jerusalem. 1969; 237–261
   Google Scholar
• Morris H. P. Some growth, morphological and biochemical characteristics of hepatoma 5123 and other new transplantable hepatomas. Prog. Tumor Res 1963; 3: 370–121
   PubMedGoogle Scholar
• Morris H. P. Studies on the development, biochemistry and biology of experimental hepatomas. Adv. Cancer Res. 1965; 9: 227
   Google Scholar
• Mottram J. C. A developing factor in blastogenesis. J. Pathol. Bacteriol. 1944; 56: 181–187
   Google Scholar
• Mühlbock O. Karzinogenese, Endogenese und Exogenese. In:. Krebsforschung und Krebsbekämpfung, H. Martius. Urban und Schwarzenberg, Berlin 1957; 13–25
   Google Scholar
• Nery R. Carcinogenic mechanisms: A critical review and a suggestion that oncogenesis may be adaptive ontogenesis. Chem. Biol. Ineract. 1976; 12: 145–169
   PubMed Web of Science ®Google Scholar
• Neumann H. G. Über die Darstellung von carcinogenen Aminen aus hydrierbaren Vorstufen und die Stabilität der eingeführten Wasserstoffatome gegen Austauschreaktionen. Hoppe Seyler's Z. Physiol. Chem 1967; 148: 313–318
   Google Scholar
• Neumann H. G. Organotropie krebserzeugender Amine. Umsch. Wissensch. Technik 1970; 70: 545
   Google Scholar
• Neumann H. G. Zur Bedeutung chemisch-biologischer Wechselwirkungen für die toxische und carcinogene Wirkung aromatischer Amine. Berichte der Physikalische-medizinichen Gesellschaft zu Würzburg 1972; 80: 47–51
   Google Scholar
• Neumann H. G. Biochemical effects and early lesions in regard to dose-response-studies. Oncology 1980; 37: 255–258
   PubMed Web of Science ®Google Scholar
• Neumann G. Role of extent and persistence of DNA modifications in chemical carcinogenesis by aromatic amines. Recent Results Cancer Res 1983; 84: 77–89
   PubMedGoogle Scholar
• Neumann H. G. The dose dependence of DNA interactions of aminostilbene derivatives and other chemical carcinogens. In:. Developments in the Science and Practice of Toxicology, A.W. Hayes, R.C. Schnell, T.S. Miya. Elsevier Biomedical Press, Amsterdam 1983; 135–144, ICT III
   Google Scholar
• Neumann H. G. Dosimetry and dose-response relationships. IARC Scientifi. Publications 1984; 59: 115–126
   Google Scholar
• Neumann H. G. Initiation and promotion of liver lesions. In:. Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, C.M. King, L.J. Romano, D. Schuetzle. Elsevier, New York 1988; 241–247
   Google Scholar
• Neumann H. G. The role of initiating and promoting properties in aromatic amine carcinogenesis. In:. Carcinogenesis, Models and Mechanisms, Feo F., Pani P., Columbano A., Garcea R. Plenum Press, New York 1988; 243–250
   Google Scholar
• Neumann H. G., Ambs S., Bitsch A. The role of nongenotoxic mechanisms in arylamine carcinogenesis. Environ. Health Perspect 1994; 102: 173–176, supl.
   PubMed Web of Science ®Google Scholar
• Neumann H. G., Metzler M., Brachmann I., Thomas C. Zur Bedeutung chemisch–biologischer Wechselwirkungen für die toxische und krebserzeugende Wirkung aromatischer Amine. I. Krebserzeugende Wirksamkeit einiger 4-Aminostilben-und 4-Aminobibenzyl–Verbindungen. Z. Krebsforsch 1970; 74: 200–206
   PubMedGoogle Scholar
• Neumann H. G., van Dorp C., Zwirner-Baier I. The implications for risk assessment of measuring the relative contribution to exposure from occupation, environment and lifestyle: Haemoglobin adducts from amino-and nitro-arenes. Toxicol. Lett. 1995; 82/83: 771–778
   Web of Science ®Google Scholar
• Ogawa K., Kaneko A., Minase T., Onoe T. Persistent changes induced by subcarcinogenic doses of 3′-methyl-4-dimethylaminoazobenzene in rat liver. Gann 1974; 65: 109–117
   PubMedGoogle Scholar
• Paku S., Nagy P., Kopper L., Thorgeirsson S. S. 2-Acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: Confocal and electron microscopic studies. Hepatology 2004; 39: 1353–1361
   PubMed Web of Science ®Google Scholar
• Pataki J., Huggins C. Relation of methyl and ethyl substitution of benzo(a)anthracene to carcinogenicity. In:. Physico-Chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, E.D. Bergmann, B. Pullman. Jerusalem. 1969; 64–71
   Google Scholar
• Paul D., Hecker E. On the biochemical mechanism of tumorigenesis in mouse skin: Early effects on the biosynthesis of nucleic acids induced by initiating doses of DMBA and by promoting doses of phorboldiester TPA. Z. Krebsforsch 1969; 73: 149–163
   PubMedGoogle Scholar
• Peraino C., Frey R. J., Staffeldt E., Kisieleski W. E. Effects of varying the exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis. Cancer Res 1973; 33: 2701–2705
   PubMed Web of Science ®Google Scholar
• Peraino C., Fry M. R.J., Staffeldt E. Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene. Cancer Res. 1971; 31: 1506–1512
   PubMed Web of Science ®Google Scholar
• Pitot H. Fundamentals in Oncology2nd ed. Marcel Decker, New york 1980
   Google Scholar
• Pitot H. C., Sirika A. E. The stages of initiation and promotion in hepatocarcinogenesis. Biochim. Biophys. Acta 1980; 605: 191–215
   PubMed Web of Science ®Google Scholar
• Price J. M., Harman J. W., Miller EC., Miller J. A. Progressive microscopic alterations in the livers of rats by the hepatic carcinogens 3′-methyl-4-dimethylaminoazobenzene and 4′-fluoro-4-dimethylaminoazobenzene. Cancer Res 1952; 12: 192–206
   PubMedGoogle Scholar
• Rappaport A. M., Borowy Z. J., Lougheed W. M., Lotto W. N. Subdivision of hexagonal liver lobules into a structural and functional unit, rolein hepatic physiology and pathology. Anat. Rec 1954; 119: 11–34
   PubMedGoogle Scholar
• Reed R. C., Green. D.R. Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis. Mol. Cell 2002; 9: 1–3
   PubMed Web of Science ®Google Scholar
• Richter R. C. Do mitochondrial DNA fragments promote cancer and aging. FEBS Lett. 1988; 241: 1–5
   PubMed Web of Science ®Google Scholar
• Richter C., Kass G. E.N. Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation. Chem. Biol. Interact. 1991; 77: 1–23
   PubMed Web of Science ®Google Scholar
• Rippmann F., Hecker E. General quantitative dose/time (response) relationship for solitary cancerogenesis and initiation/ promotion in skin of NMRI-mice and its implication for risk assessment. Naunyn-Schmiedeberg's Arch Pharmacol. 1988; 338, (Suppl.):R86.
   Google Scholar
• Rissler P., Torndal U. B., Eriksson L. C. Induced drug resistance inhibits selection of initiated cells and cancer development. Carcinogenesis 1997; 18: 649–655
   PubMed Web of Science ®Google Scholar
• Ritchi A. C., Saffiotti U. Orally administered 2-acetylaminofluorene as an initiator and promoter in epidermal carcinogenesis in the mouse. Cancer Res 1955; 15: 84–88
   PubMed Web of Science ®Google Scholar
• Rubin H. Is somatic mutation the major mechanism of malignant transformation. J. Natl. Cancer Inst 1980; 64: 995–1000
   PubMed Web of Science ®Google Scholar
• Ruch R. J., Klaunig J. E. Effects of tumor promoters, genotoxic carcinogens and hepatic cytotoxines on mouse hapatocyte intercellular communication. Cell Biol. Toxicol 1986; 2: 469–483
   PubMed Web of Science ®Google Scholar
• Schaff Z., Lapis K., Henson D. E. Kapitel 9 liver. In:. The Pathology of Incipient Neoplasia, D.E. Henson, J. Albores-Saavedra. W.B. Saunders, Philadelphia 1986; 167–202
   Google Scholar
• Scherer E., Emmelot P. Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. Cancer Res 1976; 36: 2544–2554
   PubMed Web of Science ®Google Scholar
• Scherer E., Feringa A. W., Emmelot P. Initiation–promotion–initiation. Induction of neoplastic foci with islands of precancerous liver cells in the rat. IARC Sci. Publ 1984; 56: 57–66
   Google Scholar
• Schulte-Herman R. Tumor promotion in the liver. Arch. Toxicol 1985; 57: 147–158
   PubMed Web of Science ®Google Scholar
• Schulte-Hermann R. Initiation and promotion in hepatocarcinogenesis. Arch. Toxicol. 1987; 60: 179–181
   PubMed Web of Science ®Google Scholar
• Schulte-Hermann R., Bursch W., Fesus L., Kraupp B. Cell death by apoptosis in normal, preneoplastic and neoplastic tissue. In. Chemical Carcinogenesis, Models and Mechanisms, F. Feo, P. Pani, A. Columbano, R. Garcea. Plenum Press, New York 1988; 263–274
   Google Scholar
• Scribner J. D., Fist S. R., Scribner N. K. Mechanisms of action of carcinogenic aromatic amines: an investigation using mutagenesis in bacteria. Chem. Biol. Chem. Biol. Interact. 1979; 26: 11–25
   PubMed Web of Science ®Google Scholar
• Scribner J. D., Koponen D. Binding of the carcinogen 2-acetamidophenanthrene to rat liver nucleic acids: Lack of correlation with carcinogenic activity, and failure of the hydroxamic acid ester model for in vivo activation. Chem. Biol. Interact. 1979; 28: 201–209
   PubMed Web of Science ®Google Scholar
• Scribner J. D., Woodworth B., Koponen G., Holmes E. H. Use of 2-acetylaminophenanthrene and 2-acetylaminofluorene in investigeations of mechanisms of hepatocarcinogenesis. Environ. Health Perspect 1983; 49: 81–86
   PubMedGoogle Scholar
• Sell S., Salman J. Light-and electron.microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding. luorenylacetamide in a choline-deficient diet. Am. J. Pathol 1984; 114: 287–300
   Google Scholar
• Shay J. W., Werbin H. Are mitochondrial DNA mutations involved in the carcinogenic process. Mutat. Res 1987; 186: 149–160
   PubMed Web of Science ®Google Scholar
• Shirai T., King C. M. Sulfotransferase and deacetylase in normal and tumor-bearing CD rats. Autoradiographical studies with N-hydroxy-2-acetylaminofluorene and N-hydroxy-4-acetaminobiphenyl. Carcinogenesis 1982; 3: 1385–1391
   PubMed Web of Science ®Google Scholar
• Shirasu Y., Grantham P. H., Weisburger E. K., Weisburger J. K. Metabolism of continously fed 14 C-labeled N-hydroxy-N-2-fluorenylacetamide at various intervals. Effects of pituitary hormones. Cancer Res 1967; 27: 865–872
   PubMed Web of Science ®Google Scholar
• Sies H., Brigelius R., Wefers H., Müller A., Cadenas E. Cellular redox changes and response to drugs and toxic agents. Fundam. Appl. Toxicol 1983; 3: 200–208
   PubMedGoogle Scholar
• Steiner P. A. Cancer: Race and Geography,. Williams & Wilkins, Baltimore 1954; 281–295
   Google Scholar
• Stenbäck F., Gebhardt R., Sirma H., Garbay J. M., Williams G. M. Sequential functional and morphological alterations during hepatocarcinogenesis induced in rats by feeding a low dose of 2-acetylaminofluorene. Toxicol. Pathol 1994; 22: 620–632
   PubMed Web of Science ®Google Scholar
• Sugimura T., Ushijima T. Genetic and epigenetic alterations in carcinogenesis. Mutat. Res. 2000; 462: 235–246
   PubMed Web of Science ®Google Scholar
• Sutton P. M. Parenchymal cell damage and bile duct activity in the precancerous liver. Br. J. Cancer 1962; 15: 619–625
   Google Scholar
• Teebor G. W., Becker F. F. Expression and persistence of hyperplastic nodules induced by N-2-fluorenylacetamide and their relationship to carcinogenesis. Cancer Res 1971; 31: 1–3
   PubMed Web of Science ®Google Scholar
• Tellgren A., Wood T. J.J., Flores-Morales A., Torndal U. B., Eriksson L., Norstedt G. Differentially expressed transcripts in neoplastic nodules and neonatal rat liver studied by cDNA microarray analysis. Int. J. Cancer 2003; 104: 131–138
   PubMed Web of Science ®Google Scholar
• Thorgeirsson S. S. Modulation of gene expression during early stages of chemical hepatocarcinogenesis. In:. Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, C.M. King, L.J. Romano, D. Schuetzle. Elsevier, New York 1988; 315–320
   Google Scholar
• Thorgeirsson S. S., Nagy P., Evarts R. P. Cellular and molecular changes in early stages of carcinogenesis. In:. Carcinogenesis, Models and Mechanisms, Feo F., Pani. P., Columbano A., Garcea R. Plenum Press, New York 1988; 203–208
   Google Scholar
• Travis C. C., Belefant H. Promotion as a factor in carcinogenesis. Toxicol. Letters 1992; 60: 1–9
   PubMed Web of Science ®Google Scholar
• Umemura T., Tokumo K., Sirma H., Gebhardt R., Poirier M. C., Williams G. M. dose-response effects of 2-acetylaminofluorene on DNA-damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver. Cancer Lett. 1993; 73: 1–10
   PubMed Web of Science ®Google Scholar
• Wallace K. B., Starkov A. A. Mitochondrial targets of drug toxicity. Annu. Rev. Pharmacol. Toxicol 2000; 40: 353–388
   PubMed Web of Science ®Google Scholar
• Walpole A. L. Initiation and promotion in carcinogenesis, In:. Ciba Foundation Symposium on Carcinogenesis, Mechanisms of Action, G.E.W. Wolstenholme, M. O'Connor. J & A Churchill, London 1959; 41–50
   Google Scholar
• Warwick G. P. The covalent binding of metabolites of 4-dimethylaminoazobenzene to liver nucleic acids in vitro, the possible importance of cell proliferation in cancer initiation, In:. Physico-Chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, E.D. Bergmann, B. Pullman. Jerusalem. 218–225
   Google Scholar
• Weisburger J. H., Grantham P. H., Weisburger E. K. The transport of chemical carcinogens by blood–metabolites of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide as a function of time, In:. Physico-Chemical Mechanisms of Carcinogenesis, The Jerusalem Symposia on Quantum Chemistry and Biochemistry, E.D. Bergmann, B. Pullman. Jerusalem. 1969; 262–283
   Google Scholar
• Weissenfels N. Der Feinbau und das Verhalten der Mitochondrien in Tumorzellen. In:. Krebsforschung und Krebsbekämpfung, H. Martius, H. Hartl. Urban und Schwarzenberg, Berlin 1957; 102–110
   Google Scholar
• Weitberg A. B., Weitzman S. A., Destrempes M., Latt S. A., Stossel T. P. Stimulated human phagocytes produce cytogenetic changes in cultured mammalian cells. N. Engl. J. Med 1983; 308: 26–30
   PubMed Web of Science ®Google Scholar
• Wieland E., Neumann H. G. Methemoglobin formation and binding to blood constituents as indicators of for the formation, availability and reactivity of activated metabolites derived from trans-4-aminostilbene and related aromatic amines. Arch. Toxicol. 1978; 40: 17–35
   PubMed Web of Science ®Google Scholar
• Wilkie D., Evans I. H., Egilsson V., Diala E. S., Collier D. Mitochondria, cell surface, and carcinogenesis. Intern. Rev. Cytol. Suppl 1983; 15: 157–189
   PubMedGoogle Scholar
• Williams G. M. The pathogenesis of rat liver cancer by chemical carcinogens. Biochim. Biophys. Acta 1980; 605: 167–189
   PubMed Web of Science ®Google Scholar
• Williams G. M., Iatropoulos M. J., Wang C. X., Jeffrey A. M., Thompson S., Pittmann P., Gebhardt R. Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. Toxicol. Sc 1998; 45: 152–161
   PubMed Web of Science ®Google Scholar
• Wolf G. Chemical Induction of Cancer,. Harvard University Press, Cambridge, MA 1952, 46 ff, 121ff.
   Google Scholar
• Wunderlich V. Mechanismus der chemischen Kanzerogenese: Fortschritte und Probleme. Arch. Geschwulstforsch 1971; 38: 310–326
   PubMedGoogle Scholar
• Yoon B. I., Choi Y. K., Kim D. Y. Differentiation processes of oval cells into hepatocytes: proposal based on morphological and phenotypical traits in carcinogen-treated hamster liver. J. Comp. Pathol 2004; 131: 1–9
   PubMed Web of Science ®Google Scholar
• Zahraoui A. Tight junctions, a platform regulating cell proliferation and polarity. Med. Sci. (Paris) 2004; 20: 580–585
   PubMed Web of Science ®Google Scholar
• Zwirner-Baier I, Neumann H. G. Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust. Mutat. Res 1999; 441: 135–144
   PubMed Web of Science ®Google Scholar