Addiction and Dose Response: The Psychomotor Stimulant Theory of Addiction Reveals That Hormetic Dose Responses Are Dominant

REFERENCES

• Ahlenius S., Carlsson A., Engel J., Svensson T., Soderste F. K. Antagonism by alpha methyltyrosine of ethanol-induced stimulation and euphoria in man. Clin. Pharmacol. Ther. 1973; 14: 586–591
   PubMed Web of Science ®Google Scholar
• Anisman H. Fear reduction and active avoidance learning after alcohol administration during prior CS-shock exposure. Q. J. Stud. Alcohol 1972; 33: 783–793
   PubMedGoogle Scholar
• Babbini M., Gaiardi M., Bartoletti M. Dose-time motility effects of morphine and methadone in naive and morphinized rats. Pharmacol. Res. Commun. 1979; 11: 809–816
   PubMedGoogle Scholar
• Battig K., Driscoll P., Schlatter J., Uster J. H. Effects of nicotine on the exploratory locomotion patterns of female Roman high- and low-avoidance rats. Pharmacol. Biochem. Behav. 1976; 4: 435–439
   PubMed Web of Science ®Google Scholar
• Bechtholt A. J., Mark G. P. Enhancement of cocaine-seeking behavior by repeated nicotine exposure in rats. Psychopharmacology 2002; 162: 178–185
   PubMed Web of Science ®Google Scholar
• Belknap J. K., MacInnes J.W., McClearn G.E. Ethanol sleep times and hepatic alcohol and aldehyde dehydrogenase activities in mice. Physiol. Behav. 1973; 9: 453–457
   Web of Science ®Google Scholar
• Berry M. S. Ethanol-induced enhancement of defensive behavior in different models of murine aggression. J. Stud. Alcohol 1993; 11: 156–162
   Google Scholar
• Blanchard R. J., Hori K., Flannelly K., Blanchard D. C. The effects of ethanol on the offense and defensive behaviors of male and female rats during group formation. Pharmacol. Biochem. Behav. 1987; 26: 61–64
   PubMed Web of Science ®Google Scholar
• Boissier J. R., Simon P. Action de la caffeine sur la motilite spontanee de la souris. Arch. Int. Pharmacodyn. 1965; 158: 212–221
   PubMedGoogle Scholar
• Boren J. L., Consroe P. F. Behavioral effects of phencyclidine (PCP) in the dog: A possible animal model of PCP toxicity in humans. Life Sci. 1981; 28: 1245–1251
   PubMed Web of Science ®Google Scholar
• Branham S. E. The effects of certain chemical compounds upon the course of gas production by baker's yeast. J. Bacteriol. 1929; 18: 247–264
   PubMedGoogle Scholar
• Broadhurst P. L., Wallgren H. Ethanol and the acquisition of a conditioned avoidance response in selected strains of rats. Q. J. Stud. Alcohol 1964; 25: 476–489
   PubMedGoogle Scholar
• Burnstock G., Brown C. M. An introduction to purinergic receptors. Purinergic Receptors, G. Burnstock. Chapman & Hall, London 1981; 1–45
   Google Scholar
• Butcher R. W., Sutherland E. W. Adenosine 3′,5′-phosphate in biological materials. 1. Purification and properties of cyclic 3′,5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′,5′-phosphate in human urine. J. Biol. Chem. 1962; 237: 1244–1250
   PubMed Web of Science ®Google Scholar
• Cabib S., Bonaventura N. Parallel strain-dependent susceptibility to environmentally-induced sterotypes and stress-induced behavioral sensitization in mice. Physiol. Behav. 1997; 61: 499–506
   PubMed Web of Science ®Google Scholar
• Calabrese E. J. Paradigm lost, paradigm found: The re-emergence of hormesis as a fundamental dose response model in the toxicological sciences. Environ. Pollut. 2005; 138: 378–411
   Web of Science ®Google Scholar
• Calabrese E. J. U-shaped dose-response in behavioral pharmacology: historical foundations. Crit. Rev. Toxicol. 2008a, this issue
   Web of Science ®Google Scholar
• Calabrese E. J. Hormesis: Why it is important to toxicology and toxicologists. Environ. Toxicol. Chem. 2008b; 27: 1451–1474
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. The dose determines the strimulation (and poison): Development of a chemical hormesis database. Intern'l. J. Toxicol. 1997; 16: 545–559
   Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. The frequency of U-shaped dose-responses in the toxicological literature. Tox. Sci. 2001a; 62: 330–338
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. Hormesis: U-shaped dose responses and their centrality in toxicology. Trends Pharmacol. Sci. 2001b; 22: 285–291
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. Application of hormesis in toxicology, risk assessment and chemotherapeutics. Trends Pharmacol. Sci. 2002; 23: 331–337
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. Toxicology rethinks its central belief—Hormesis demands a reappraisal of the way risks are assessed. Nature 2003a; 421(6924)691–691
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. Ethanol and hormesis. Crit. Rev. Toxicol. 2003b; 33: 407–424
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Baldwin L. A. The hormetic dose response model is more common than the threshold model in toxicology. Tox. Sci. 2003c; 71: 246–250
   PubMed Web of Science ®Google Scholar
• Calabrese E. J., Blain R. The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: An overview. Toxicol. Appl. Pharmacol. 2005; 202: 289–301
   PubMed Web of Science ®Google Scholar
• Cappell H., LeBlanc E., Endrenyi L. Effects of chlordiazepoxide and ethanol on the extinction of a conditioned taste aversion. Physiol. Behav. 1972; 9: 167–169
   PubMed Web of Science ®Google Scholar
• Carlsson A., Engel J., Strombom U., Svensson T. H., Waldeck B. Suppression by dopamine-agonists of ethanol-induced stimulation of locomotor activity and brain dopamine synthesis. Naunyn-Schmiedbergs Arch. Pharmacol. 1974; 283: 117–128
   PubMed Web of Science ®Google Scholar
• Carlsson A., Engel J., Svensson T. H. Inhibition of ethanol-induced excitation in mice and rats by α -methyl-p-tyrosine. Psychopharmacologia 1972a; 26: 307–312
   PubMedGoogle Scholar
• Carlsson A., Davis J. N., Kehr W., Lindqvis M., Atack C. V. Simulanteous measurement of tyrosine and tryptophan hydroxylase-activities in brain in-vivo using an inhibitor of aromatic amino-acid decarboxylase. Naunyn-Schmiedebergs Arch. Pharmacol. 1972b; 275: 153–168
   PubMed Web of Science ®Google Scholar
• Castellani S., Adams P. M. Effects of dopaminergic drugs on phencyclidine-induced behavior in the rat. Neuropharmacology 1981; 20: 371–374
   PubMed Web of Science ®Google Scholar
• Chance M. R.A., Mackintosh J. H., Dixon A. K. The effects of ethyl alcohol on social encounters between mice. J. Alcohol 1973; 8: 90–93
   Web of Science ®Google Scholar
• Cherek D. R., Steinberg J. L., Vines R. V. Low doses of alcohol affect human aggressive responses. Biol. Psychiatry 1984; 19: 263–267
   PubMed Web of Science ®Google Scholar
• Clarke P. B.S., Kumar R. The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br. J. Pharmacol. 1983; 78: 329–337
   PubMed Web of Science ®Google Scholar
• Cohen C., Perrault G., Sanger D. J. Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice. Neuropharmacology 1997; 36: 1099–1108
   PubMed Web of Science ®Google Scholar
• Collins A. C., Miner L. L., Marks M. J. Genetic influences on acute responses to nicotine and nicotine tolerance in the mouse. Pharmacol. Biochem. Behav. 1988; 30: 269–278
   PubMed Web of Science ®Google Scholar
• Cooper S. J. Benzodiazepines as appetite-enhancing compounds. Appetite 1980; 1: 7–19
   Web of Science ®Google Scholar
• Corrigall W. A., Franklin K. B.J., Coen K. M., Clarke P. B.S. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology 1992; 107: 285–289
   PubMed Web of Science ®Google Scholar
• Crabbe J. C. Genetic animal models in the study of alcoholism. Alcohol. Clin. Exp. Res. 1989; 13: 120–127
   PubMed Web of Science ®Google Scholar
• Crabbe J. C., Metten P., Gallaher E. J., Belknap J. K. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology 2002; 161: 408–416
   PubMed Web of Science ®Google Scholar
• Crabbe J. C., Kosobud A., Young E. R., Janowsky J. S. Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains. Neurobehav. Toxicol. Teratol. 1983; 5: 181–187
   PubMedGoogle Scholar
• Crabbe J. C., Johnson N., Gray D., Kosobud A., Young E. R. Biphasic effects of ethanol on open-field activity: Sensitivity and tolerance in C57/6N and DBA/2N mice. J. Comp. Physiol. Psychol. 1982; 96: 440–451
   PubMed Web of Science ®Google Scholar
• Crabbe J. C., Gallaher E. S., Phillips T. J., Belknap J. K. Genetic determinants of sensitivity to ethanol in inbred mice. Behav. Neurosci. 1994; 108: 186–195
   PubMed Web of Science ®Google Scholar
• deAlmeida R. M.M., Rowlett J. K., Cook J. M., Miczek K. A. GABAA/α 1 receptor agonists and antagonists: Effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice. Psychopharmacology 2004; 172: 255–263
   PubMed Web of Science ®Google Scholar
• Domino E. F. Sites of action of some central nervous system depressants. Ann. Rev. Pharmacol. 1962; 2: 215–268
   Google Scholar
• Dudeck B. C., Phillips T. J., Hahn M. E. Genetic analyses of the biphasic nature of the alcohol dose-response curve. Alcohol Clin. Exp. Res. 1991; 15: 262–269
   PubMed Web of Science ®Google Scholar
• Dudeck B. C., Abbott M. E., Phillips T. J. Stimulant and depressant properties of sedative-hypnotics in mice selectively bred for differential sensitivity to ethanol. Psychopharmacology 1984; 82: 46–51
   PubMed Web of Science ®Google Scholar
• El Yacoubi M., Ledent C., Menard J.-F., Parmentier M., Costentin J., Vaugeois J-M. The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A2 receptors. Br. J. Pharmacol. 2000; 129: 1465–1473
   PubMed Web of Science ®Google Scholar
• Erwin V. G., Radcliffe R. A., Gehle V. M., Jones B. C. Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: Locomotor activation. J. Pharmacol. Exp. Ther. 1997; 280: 919–926
   PubMed Web of Science ®Google Scholar
• Erwin V. G., Jones B. C. Genetic correlations among ethanol-related behaviors and neurotensin receptors in long sleep (LS) × short sleep (SS) recombinant inbred strains of mice. Behav. Genet. 1993; 23: 191–196
   PubMed Web of Science ®Google Scholar
• Erwin V. G., Radcliffe R. A., Jones B. C. Chronic ethanol-consumption produces genotype-dependent tolerance to ethanol in LS/IBG and SS/IBG mice. Pharmacol. Biochem. Behav. 1992; 41: 275–281
   PubMed Web of Science ®Google Scholar
• Fahey J. M., Lindquist D. G., Pritchard G. A., Miller L. G. Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical-neurons. Brain Res. 1995a; 669: 183–188
   PubMed Web of Science ®Google Scholar
• Fahey J. M., Miller L. G., Isaacson R. L. Neurosteroid modulation of locomotor activity in mice. Neurosci. Res. Commun. 1995b; 17(3)159–159
   Google Scholar
• Faraday M. M., O'Donoghue V.A., Grunberg N. E. Effects of nicotine and stress on locomotion in Sprague-Dawley and Long-Evans male and female rats. Pharmacol. Biochem. Behav. 2003a; 74: 325–333
   PubMed Web of Science ®Google Scholar
• Faraday M. M., Elliott B. M., Phillips J. M., Grunberg N. E. Adolescent and adult male rats differ in sensitivity to nicotine's activity effects. Pharmacol. Biochem. Behav. 2003b; 74: 917–931
   PubMed Web of Science ®Google Scholar
• Finn I. B., Holtzman S. G. Pharmacologic specificity of tolerance to caffeine-induced stimulation of locomotor activity. Psychopharmacology 1987; 93: 428–434
   PubMed Web of Science ®Google Scholar
• Fish E. W., DeBold J.F., Miczek K. A. Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice. Psychopharmacology 2002; 160: 39–48
   PubMed Web of Science ®Google Scholar
• Fish E. W., Faccidomo S., DeBold J.F., Miczek K. A. Alcohol, allopregnanolone and aggression in mice. Psychopharmacology 2001; 153: 473–483
   PubMed Web of Science ®Google Scholar
• Flood J. F., Smith G. E., Cherkin A. Memory enhancement: Supra-additive effect of subcutaneous cholinergic drug combinations in mice. Pschopharmacology 1985; 86: 61–67
   PubMed Web of Science ®Google Scholar
• Fog R. Behavioral effects in rats of morphine and amphetamine and of a combination of the two drugs. Pharmacologia 1970; 16: 305–312
   Google Scholar
• Fredholm B. B., Fuxe K., Agnati L. Effect of some phosphodiesterase inhibitors on central dopamine mechanisms. Eur. J. Pharmacol. 1976; 38: 31–38
   PubMed Web of Science ®Google Scholar
• Friedman H. J., Carpenter J. A., Lester D., Randall C. L. Effect of alpha-methyl-p-tyrosine on dose-dependent mouse strain differences in locomotor activity after ethanol. J. Studies Alcohol 1980; 41: 1–7
   PubMedGoogle Scholar
• Frye G. D., Breese G. R. An evaluation of the locomotor stimulating action of ethanol in rats and mice. Psychopharmacology 1981; 75: 372–379
   PubMed Web of Science ®Google Scholar
• Gaddnas H., Pietila K., Piepponen T. P., Ahtee L. Enhanced motor activity and brain dopamine turnover in mice during long-term nicotine administration in the drinking water. Pharmacol. Biochem. Behav. 2001; 70: 497–503
   PubMed Web of Science ®Google Scholar
• Gaddnas H., Pietila K., Ahtee L. Effects of chronic oral nicotine treatment and its withdrawal on locomotor activity and brain monoamines in mice. Behav. Brain Res. 2000; 113: 65–72
   PubMed Web of Science ®Google Scholar
• Garg M. Effect of nicotine on rearing in two strains of rat. Life Sci. 1968; 7: 421–429
   PubMedGoogle Scholar
• Garg M. The effects of some central nervous system stimulant and depressant drugs on rearing activity in rats. Psychopharmacologia 1969a; 14: 150–156
   PubMed Web of Science ®Google Scholar
• Garg M. Variation in effects of nicotine in four strains of rats. Psychopharmacologia 1969b; 14: 432–438
   PubMed Web of Science ®Google Scholar
• Gerasimov M. R., Franceschi M., Volkow N. D., Rice O., Schiffer W. K., Dewey S. L. Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. Synapse 2000; 38: 432–437
   PubMed Web of Science ®Google Scholar
• Gingras M. A., Cools A. R. Analysis of the biphasic locomotor response to ethanol in high and low responders to novelty: A study in Nijmegen Wistar rats. Psychopharmacology 1996; 125: 258–264
   PubMed Web of Science ®Google Scholar
• Glick S. D., Milloy S. Increased and decreased eating following THC administration. Psychonomic Sci. 1972; 29: 6
   Google Scholar
• Glickman S. E., Schiff B. B. A biological theory of reinforcement. Psychol. Rev. 1967; 74: 81–109
   PubMed Web of Science ®Google Scholar
• Goldstein A., Kaizer S. Psychotropic effects of caffeine in man. III. A questionnaire survey of coffee drinking and its effects in a group of housewives. Clin. Pharmacol. Exp. Ther. 1969; 10: 477–488
   PubMed Web of Science ®Google Scholar
• Goldstein A., Kaizer S., Whitley O. Phenotypic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee. Clin. Pharmacol. Exp. Ther. 1969; 10: 489–497
   PubMed Web of Science ®Google Scholar
• Halldner L., Aden U., Dahlberg V., Johansson B., Ledent C., Fredholm B. B. The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: A study in mice lacking adenosine A1 and/or A2A receptors. Neuropharmacology 2004; 46: 1008–1017
   PubMed Web of Science ®Google Scholar
• Hatchell P. C., Collins A. C. The influence of genotype and sex on behavioral sensitivity to nicotine in mice. Psychopharmacology (Berlin) 1980; 71: 45–59
   PubMed Web of Science ®Google Scholar
• Hatchell P. C., Collins A. C. Influences of genotype and sex on behavioral tolerance to nicotine in mice. Pharmacol. Biochem. Behav. 1977; 6: 25–30
   PubMed Web of Science ®Google Scholar
• Heim F., Haas B. Der einfluss von megaphen auf motilitat und sauerstoffverbrauch weisser mause in ruhe und erregung. Arch. Exp. Path. Pharmakol. 1955; 226: 395–402
   PubMedGoogle Scholar
• Heim F., Hack B., Mitznegg P., Ammon H. P.T., Estler C.-J. Caffeine-antagonistic effects of theobromine and caffeine-like properties of theobromine metabolites. Arzneimittel.-Forsch. 1971; 21: 1039
   PubMedGoogle Scholar
• Herz A., Neteler B., Teschemacher H. J. Experiments comparing central nervous system effects of xanthine derivatives and their metabolism and distribution in body. Arch. Exp. Path. Pharmakol. 1968; 261: 486
   Google Scholar
• Holloway F. A. State-dependent effects of ethanol on active and passive avoidance learning. Psychopharmacologia 1972; 25: 238–261
   PubMedGoogle Scholar
• Holloway W. R., Thor D. H. Caffeine sensitivity in the neonatal rat. Behav. Toxicol. Teratol. 1982; 4: 331–333
   PubMedGoogle Scholar
• Hughes R. N., Greig A. M. Effects of caffeine, methamphetamine and methylphenidate on reactions to novelty and activity in rats. Neuropharmacology 1976; 15: 673–676
   PubMed Web of Science ®Google Scholar
• Itzhak Y., Martin J. L. Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: Cocaine–alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. Brain Res. 1999; 818: 204–211
   PubMed Web of Science ®Google Scholar
• Jacobs B. L., Farel P. B. Motivated behaviors produced by increased arousal in the presence of goal objects. Physiol. Behav. 1971; 6: 473–476
   PubMed Web of Science ®Google Scholar
• Jarvis M. F., Williams M. Differences in adenosine A-1 and A-2 receptor density revealed by autoradiography in methylxanthine-sensitive and insensitive mice. Pharmacol. Biochem. Behav. 1988; 30: 707–714
   PubMed Web of Science ®Google Scholar
• Kalivas P. W., Duffy P. Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. J. Neurochem. 1988; 50: 1498–1504
   PubMed Web of Science ®Google Scholar
• Katims J. J., Annau Z., Snyder S. H. Interactions in the behavioral effects of methylxanthines and adenosine derivatives. J. Pharmacol. Exp. Ther. 1983; 227: 167–173
   PubMed Web of Science ®Google Scholar
• Kiianmaa K., Tuomainen P., Makova N., Seppa T., Mikkola J. A.V., Piepponen T. P., Ahtee L., Hyytia P. The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats. Eur. J. Pharmacol. 2000; 407: 293–302
   PubMed Web of Science ®Google Scholar
• Klotz K.-N., Hessling J., Hegler J., Owman C., Kull B., Fredholm B. B., Lohse M. J. Comparative pharmacology of human adenosine receptor subtypes—Characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 1997; 357: 1–9
   Google Scholar
• Krsiak M., Borgesova M. Effect of alcohol on behaviour of pairs of rats. Psychopharmacologia 1973; 32: 201–209
   PubMedGoogle Scholar
• Ksir C. Acute and chronic nicotine effects on measures of activity in rats: a multivariate analysis. Psychopharmacology 1994; 115: 105–109
   PubMed Web of Science ®Google Scholar
• Ksir C., Hakan R. L., Kellar K. J. Chronic nicotine and locomotor activity: Influences of exposure dose and test done. Psychopharmacology 1987; 92: 25–29
   PubMed Web of Science ®Google Scholar
• Ksir C., Hakan R., Hall D. P., Kellar K. J., Jr. Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors. Neuropharmacology 1985; 24: 527–531
   PubMed Web of Science ®Google Scholar
• Le A. D., Tomkings D., Higgins G., Quan B., Sellers E. M. Effects of 5-HT3, D-1 and D-2 receptor antagonists on ethanol- and cocaine-induced locomotion. Pharmacol. Biochem. Behav. 1997; 57: 325–332
   PubMed Web of Science ®Google Scholar
• Ledent C., Vaugeois J.-M., Schiffmann S. N., Pedrazzini T., El Yacoubi M., Vanderhaeghen J. J., Costentin J., Heath J. K., Vassart G., Parmentier M. Aggressiveness, hypoalgesia, and high blood pressure in mice lacking the adenosine A2A receptor. Nature 1997; 388: 674–678
   PubMed Web of Science ®Google Scholar
• Logan L., Seale T. W., Carney J. M. Inherent differences in sensitivity to methylxanthines among inbred mice. Pharmacol. Biochem. Behav. 1986; 24: 1281–1286
   PubMed Web of Science ®Google Scholar
• London C., Wolff J., Cooper D. M.F. Adenosine as a regulator of adenylate cyclase. Purinergic Receptors, G. Burnstock. Chapman & Hall, London 1981; 287–323
   Google Scholar
• Matchett J. A., Erickson C. K. Alteration of ethanol-induced changes in locomotor-activity by adrenergic blockers in mice. Psychopharmacology 1977; 52: 201–206
   PubMed Web of Science ®Google Scholar
• Machett J. A. The effects of acute ethanol administration on central catecholamines and behavior in the mouse. Dissertation, University of Kansas, Lawrence 1976
   Google Scholar
• Majewska M. D., Schwartz R. D. Pregnenolone-sulfate—An endogenous antagonist of the gamma-aminobutyric-acid receptor complex in brain. Brain Res. 1987; 404: 355–360
   PubMed Web of Science ®Google Scholar
• Majewska M. D., Bisserbe J. C., Eskay R. L. Glucocorticoids are modulators of GABAA receptors in brain. Brain Res. 1985; 339: 178–182
   PubMed Web of Science ®Google Scholar
• Malin D. H., Lake J. R., Newlin-Maultsby P., Roberts L. K., Lanier J. G., Carter V. A., Cunningham J. S., Wilson O. B. Rodent model of nicotine abstinence syndrome. Pharmacol. Biochem. Behav. 1992; 43: 779–784
   PubMed Web of Science ®Google Scholar
• Margules D. L., Stein L. Increase of “antianxiety” activity and tolerance of behavioral depression during chronic administration of oxazepam. Psychopharmacologia 1968; 13: 74–80
   PubMedGoogle Scholar
• Mark G. P., Kinney A. E., Grubb M. C., Keys A. S. Involvement of acetylcholine in the nucleus accumbens in cocaine reinforcement. Ann. NY Acad. Sci. 1999; 877: 792–795
   PubMed Web of Science ®Google Scholar
• Marks M. J., Burch J. B., Collins A. C. Genetics of nicotine response in four inbred strains of mice. J. Pharmacol. Exp. Ther. 1983; 226: 291–302
   PubMed Web of Science ®Google Scholar
• Martin W. R., Wikler A., Eades C. G., Pescor F. T. Tolerance to and physical dependence on morphine in rats. Psychopharmacologia 1963; 4: 247–260
   PubMed Web of Science ®Google Scholar
• Masur J., Boerngen R. The excitatory component of ethanol in mice: A chronic study. Toxicol. Biochem. Behav. 1980; 13: 777–780
   PubMed Web of Science ®Google Scholar
• Masur J., Desouza M. L.O., Zwicker A. P. The excitatory effect of ethanol—Absence in rats, no tolerance and increased sensitivity in mice. Pharmacol. Biochem. Behav. 1986; 24: 1225–1228
   PubMed Web of Science ®Google Scholar
• McClearn G. E., Kakihana R. Selective breeding for ethanol sensitivity in mice. Behav. Genet. 1973; 3: 409–410
   Web of Science ®Google Scholar
• Miczek K. A., Barry H, III. Effects of alcohol on attack and defensive-submissive reactions in rats. Psychopharmacology 1977; 52: 231–237
   PubMed Web of Science ®Google Scholar
• Miczek K. A., O'Donnell J.M. Alcohol and chlordiazepoxide increase suppressed aggression in mice. Psychopharmacology 1980; 69: 39–44
   PubMed Web of Science ®Google Scholar
• Miczek K. A., Fish E. W., DeBold J.F. Neurosteroids, GABAA receptors, and escalated aggressive behavior. Hormones Behav. 2003; 44: 242–257
   PubMed Web of Science ®Google Scholar
• Miczek K. A., Weerts E. M., Tornatzky W., DeBold J.F., Vatne T. M. Alcohol and “bursts” of aggressive behavior: Ethological analysis of individual differences in rats. Psychopharmacology 1992; 107: 551–563
   PubMed Web of Science ®Google Scholar
• Miczek K. A., DeBold J.F., van Erp A.M. M. Neuropharmacological characteristics of individual differences in alcohol effects on aggression in rodents and primates. Behav. Pharmacol. 1994; 5: 407–421
   PubMed Web of Science ®Google Scholar
• Miczek K. A., Barros H. M., Sakoda L., Weerts E. M. Alcohol and heightened aggression in individual mice. Alcohol Clin. Exp. Res. 1998a; 22: 1698–1705
   PubMed Web of Science ®Google Scholar
• Miczek K. A., Hussain S., Faccidomo S. Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists. Psychopharmacology 1998b; 139: 160–168
   PubMed Web of Science ®Google Scholar
• Mienville J.-M., Vicini S. Pregnenolone sulfate antagonizes GABAA-receptor-mediated currents via a reduction of channel opening frequency. Brain Res. 1989; 489: 190–194
   PubMed Web of Science ®Google Scholar
• Mori K., Winter W. D., Spooner C. E. Comparison of reticular and cochlear multiple unit activity with auditory evoked responses during various stages induced by anesthetic agents. Electroencephalogr. Clin. NeuroPhysiol. 1968; 24: 242–248
   PubMedGoogle Scholar
• Morrison C. F., Lee P. N. A comparison of the effects of nicotine and physostigmine on a measure of activity in rat. Psychopharmacologia 1968; 13: 210–221
   PubMedGoogle Scholar
• Morrison K. F., Stephenson J. A. The occurrence of tolerance to a central depressant effect of nicotine. Br. J. Pharmacol. 1972; 45: 151–156
   Google Scholar
• Murphy N., Lam H., Maidment N. A comparison of morphine-induced locomotor activity and mesolimbic dopamine release in C57BL6, 129Sv, and DBA2 mice. J. Neurochem. 2001; 79: 626–635
   PubMed Web of Science ®Google Scholar
• Murray T. F., Horita A. Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics. Life Sci. 1979; 24: 2217–2226
   PubMed Web of Science ®Google Scholar
• Nachman M., Larue C., LeMagnen J. The role of olfactory and orosensory factors in the alcohol preference of inbred strains of mice. Physiol. Behav. 1971; 6: 53–59
   PubMed Web of Science ®Google Scholar
• Nichols R. E., Walaszek E. J. Antagonism of vasodepressor effect of ATP by caffeine. Fed. Proc. 1963; 22: 308
   Google Scholar
• Nielsen J. A., Shannon N.J., Bero L., Moore K. E. Effects of acute and chronic bupropion on locomotor-activity and dopaminergic-neurons. Pharmacol. Biochem. Behav. 1986; 24: 795–799
   PubMed Web of Science ®Google Scholar
• Nomikos G. G., Damsma G., Wenkstern D., Fibiger H. C. Effects of chronic bupropion on interstitial concentrations of dopamine in rat nucleus-accumbens and striatum. Neuropsychopharmacology 1992; 7: 7–14
   PubMed Web of Science ®Google Scholar
• Oliverio A., Eleftheriou B. E. Motor activity and alcohol: Genetic analysis in the mouse. Physiol. Behav. 1976; 16: 577–581
   PubMed Web of Science ®Google Scholar
• Panksepp J., Normansell L., Cox J. F., Crepeau L. J., Sacks D. S. Psychopharmacology of social play. Ethopharmacology of Agonistic Behaviour in Animals and Humans, B. Olivier, J. Mos, P. F. Brain. Martinus Nijhoff, Dordrecht 1987; 132–144
   Google Scholar
• Paulus M. P., Geyer M. A. A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants. Psychopharmacology 1991; 104: 6–16
   PubMed Web of Science ®Google Scholar
• Pawlak C. R., Schwarting R. K.W. Repeated nicotine treatment in rats with high versus low rearing activity: Analyses of behavioural sensitization and place preference. Psychopharmacology 2005; 178: 440–450
   PubMed Web of Science ®Google Scholar
• Peeke H. V.S., Figler M. H. Modulation of aggressive behavior in fish by alcohol and congeners. Pharmacol. Biochem. Behav. 1981; 14: 79–84
   PubMed Web of Science ®Google Scholar
• Pettijohn T. F. Effects of alcohol and caffeine on wheel running activity in the Mongolian gerbil. Pharmacol. Biochem. Behav. 1979; 10: 339–341
   PubMed Web of Science ®Google Scholar
• Phillips T. J., Huson M., Gwiazdon C., Burkhart-Kasch S., Shen E. Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol Clin. Exp. Res. 1995; 19: 269–278
   PubMed Web of Science ®Google Scholar
• Phillis J. W., Wu P. H. The role of adenosine and its nucleotide in central synaptic transmission. Prog. Neurobiol. 1981; 16: 187–239
   PubMed Web of Science ®Google Scholar
• Picciotto M. R., Zoli M., Rimondini R., Lena C., Marubio L. M., Pich E. M., et al. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 1998; 391: 173–177
   PubMed Web of Science ®Google Scholar
• Pohorecky L. A. Biphasic action of ethanol. Biobehav. Rev. 1977; 1: 231–240
   Web of Science ®Google Scholar
• Ponomarev I., Crabbe J. C. A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. J. Pharmacol. Exp. Ther. 2002; 302: 257–263
   PubMed Web of Science ®Google Scholar
• Poschel B. P.H. A simple and specific screen for benzodiazepine-like drugs. Psychopharmacologia 1971; 19: 193–198
   PubMedGoogle Scholar
• Pradhan S. N. Effects of nicotine on several schedules of behavior in rats. Arch. Int. Pharmacodyn. 1970; 183: 127–138
   PubMedGoogle Scholar
• Randall C. L., Carpenter J. A., Lester D., Friedman H. J. Ethanol-induced mouse strain differences in locomotor activity. Pharmacol. Biochem. Behav. 1975; 3: 533–535
   PubMed Web of Science ®Google Scholar
• Randall L. O., Schallek W., Heise G. A., Keith E. F., Bagdon R. E. The psychosedative properties of methaminodiazepoxide. J. Pharmacol. Exp. Ther. 1960; 129: 163–171
   PubMed Web of Science ®Google Scholar
• Rauhut A. S., Neugebauer N., Dwoskin L. P., Bardo M. T. Effect of bupropion on nicotine self-administration in rats. Psychopharmacology 2003; 169: 1–9
   PubMed Web of Science ®Google Scholar
• Raynes A. E., Ryback R. S. Effect of alcohol and congeners on aggressive response in. Betta splendens. Q. J. Stud. Alcohol 1970; 5: 130–135
   PubMedGoogle Scholar
• Read G. W., Cutting W., Furst A. Comparison of excited phases after sedatives and tranquilizers. Psychopharmacologia 1960; 1: 346–350
   PubMed Web of Science ®Google Scholar
• Rezvani A. H., Levin E. D. Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature. Int. J. Dev. Neurosci. 2004; 22: 349–354
   PubMed Web of Science ®Google Scholar
• Rosecrans J. A. Brain area nicotine levels in male and female rats with difference levels of spontaneous activity. Neuropharmacology 1972; 11: 863–870
   PubMed Web of Science ®Google Scholar
• Rosecrans J. A. Effects of nicotine on behavioral arousal and brain 5 hydroxytryptamine function in female rats selected for differences in activity. Eur. J. Pharmacol. 1971; 14: 29–37
   PubMed Web of Science ®Google Scholar
• Russell M. A.H. Nicotine intake and its regulation. J. Psychosom. Res. 1980; 24: 253–264
   PubMed Web of Science ®Google Scholar
• Sanders B. Sensitivity to low-doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol. J. Comp. Physiol. Psychol. 1976; 90: 394–398
   PubMed Web of Science ®Google Scholar
• Sattin A., Rall T. W. Effect of adenosine and adenosine nucleotides on cyclic adenosine 3′,5′-phosphate content of guinea pig cerebral cortex slices. Mol. Pharmacol. 1970; 6: 13–23
   PubMed Web of Science ®Google Scholar
• Schlatter J., Battig K. Differential effects of nicotine and amphetamine on locomotor activity and maze exploration in two rat lines. Psychopharmacology (Berlin) 1979; 64: 155–161
   PubMed Web of Science ®Google Scholar
• Schlesinger K., Bennett E. L., Hebert M. Effects of genotype and prior consumption of alcohol on rates of ethanol-1-1 4C metabolism in mice. Q. J. Stud. Alcohol 1967; 28: 231–235
   PubMedGoogle Scholar
• Schneirla T. C. An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. Nebraska Symposium on Motivation, M. R. Jones. University of Nebraska Press, Lincoln 1959; 1–42
   Google Scholar
• Seale T. W., Roderick T. H., Johnson P., Logan L., Rennert O. M., Carney J. M. Complex genetic determinants of susceptibility to methylxanthine-induced locomotor activity changes. Pharmacol. Biochem. Behav. 1986; 24: 1333–1341
   PubMed Web of Science ®Google Scholar
• Seale T. W., Johnson P., Roderick T. H., Carney J. M., Rennert O. M. A single gene difference determines relative susceptibility to caffeine-induced lethality in SWR and CBA inbred mice. Pharmacol. Biochem. Behav. 1985; 23: 275–278
   PubMed Web of Science ®Google Scholar
• Seale T. W., Johnson P., Carney J. M., Rennert O. M. Interstrain variation in acute toxic response to caffeine among inbred mice. Pharmacol. Biochem. Behav. 1984; 20: 567–573
   PubMed Web of Science ®Google Scholar
• Sheppard J. R., Albersheim P., McClearn G.E. Aldehyde dehydrogenase and ethanol preference in mice. J. Biol. Chem. 1970; 245: 2876–2882
   PubMed Web of Science ®Google Scholar
• Sheppard J. R., Albersheim P., McClearn G.E. Enzyme activities and ethanol preference in mice. Biochem. Genet. 1968; 2: 205–232
   PubMed Web of Science ®Google Scholar
• Silveri M. M., Spear L. P. The effects of NMDA and GABA(A) pharmacological manipulations on acute and rapid tolerance to ethanol during ontogeny. Alcohol Clin. Exp. Res. 2004; 28: 884–894
   PubMed Web of Science ®Google Scholar
• Silvette H., Hoff E. C., Larson P. S., Haag H. B. The actions of nicotine on central nervous system functions. Pharmacol. Rev. 1962; 14: 137–173
   PubMed Web of Science ®Google Scholar
• Slemmer J. E., Martin B. R., Damaj M. I. Bupropion is a nicotinic antagonist. J. Pharmacol. Exp. Ther. 2000; 295: 321–327
   PubMed Web of Science ®Google Scholar
• Smellie F. W., Davis C. W., Daly J. W., Wells J. N. Alkylxanthines –inhibition of adenosine-elicited accumulation of cyclic-AMP in brain-slices and of brain phosphodiesterase activity. Life Sci. 1979; 24: 2475–2483
   PubMed Web of Science ®Google Scholar
• Smoothy R., Bowden N. J., Berry M. S. Ethanol and social behaviour in naïve Swiss mice. Aggress. Behav. 1982; 8: 204–207
   Web of Science ®Google Scholar
• Snyder S. H. Knockouts anxious for new therapy. Nature 1997; 388: 624
   PubMed Web of Science ®Google Scholar
• Snyder S. H., Sklar P. Psychiatric progress. Behavioral and molecular actions of caffeine: Focus on adenosine. J. Psychiat. Res. 1989; 18: 91–106
   Google Scholar
• Snyder S. H., Katims J. J., Annau Z., Bruns R. F., Daly J. W. Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA 1981; 78: 3260–3264
   PubMed Web of Science ®Google Scholar
• Sparks J. A., Pauly J. R. Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57BL/6 mice. Psychopharmacology 1999; 141: 145–153
   PubMed Web of Science ®Google Scholar
• Spear L. P., Varlinskaya E. I. Low dose effects in psychopharmacology: Ontogentic considerations. Nonlinearity Biol. Toxicol. Med. 2005; 3: 97–111
   PubMedGoogle Scholar
• Sprugel W., Mitznegg P., Heim F. The influence of caffeine and theobromine on locomotive activity and the brain cGMP/cAMP ratio in white mice. Biochem. Pharmacol. 1977; 26: 1723–1724
   PubMed Web of Science ®Google Scholar
• Stino F. K.R. Divergent selection for pentobarbital-induced sleeping time in mice. Pharmacology 1992; 44: 257–259
   PubMed Web of Science ®Google Scholar
• Stino F. K., Samaan S. S., Kolta M. G., Mizinga K. M., Soliman K. F. Divergent selection for pentobarbital-induced sedation times in mice. Pharmacology 1998; 56: 92–100
   PubMed Web of Science ®Google Scholar
• Stohr T., Schulte WEmeling D., Weiner I., Feldon J. Rat strain differences in open-field behavior and the locomotor stimulating and rewarding effects of amphetamine. Pharmacol. Biochem. Behav. 1998; 59: 813–818
   PubMed Web of Science ®Google Scholar
• Stone T. W. Physiological roles for adenosine and adenosine 5′-triphosphate in the nervous system. Neuroscience 1981; 6: 523–555
   PubMed Web of Science ®Google Scholar
• Strombom U. H., Liedman B. Role of dopaminergic neurotransmission in locomotor stimulation by dexamphetamine and ethanol. Psychopharmacology 1982; 78: 271–276
   PubMed Web of Science ®Google Scholar
• Tabakoff B., Kiianmaa K. Does tolerance develop to the activating, as well as the depressant, effects of ethanol?. Pharmacol. Biochem. Behav. 1982; 17: 1073–1076
   PubMed Web of Science ®Google Scholar
• Thithapa A., Maling H. M., Gillette J. R. Effects of caffeine and theophylline on activity of rats in relation to brain xanthine concentrations. Proc. Soc. Exp. Biol. Med. 1972; 139: 582–586
   PubMed Web of Science ®Google Scholar
• Thor D. H., Holloway W. R., Jr. Play soliciting in juvenile male rats: Effects of caffeine, amphetamine and methylphenidate. Pharmacol. Biochem. Behav. 1983; 19: 725–727
   PubMed Web of Science ®Google Scholar
• Van Calker D., Muller M., Hamprecht B. Adenosine regulates via two different types of receptors the accumulation of cyclic AMP in cultured brain cells. J. Neurochem. 1979; 33: 999–1005
   PubMed Web of Science ®Google Scholar
• VanErp A. M.M., Miczek K. A. Aggressive behavior decreases cortical 5HT in rats: Reversal by ethanol drinking. Soc. Neurosci. Abstr. 1997; 23: 313
   Google Scholar
• Varlinskaya E. I., Spear L. P., Spear N. E. Acute effects of ethanol on behavior of adolescent rats: Role of social context. Alcohol. Clin. Exp. Res. 2001; 25: 377–385
   PubMed Web of Science ®Google Scholar
• Vasko M. R., Domino E. F. Tolerance development to the biphasic effects of morphine on locomotor activity and brain acetylcholine in the rat. J. Pharmacol. Exp. Ther. 1978; 207: 848–858
   PubMed Web of Science ®Google Scholar
• Villegier A.-S., Salomon L., Granon S., Changeux J.-P., Belluzzi J. D., Leslie F. M., Tassin J.-P. Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. Neuropsychopharmacology 2006; 31: 1704–1713
   PubMed Web of Science ®Google Scholar
• Waldeck B. Effect of caffeine on locomotor activity and central catecholamine mechanisms: a study with special reference to drug interactions. Acta Pharmacol. Toxicol. 1975; 36(Suppl. 4)1–23
   PubMedGoogle Scholar
• Weerts E. M., Miller L. G., Hood K. E., Miczek K. A. Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior. Psychopharmacology 1992; 108: 196–204
   PubMed Web of Science ®Google Scholar
• Wieland S., Belluzzi J. D., Stein L., Lan V. C. Comparative behavioral characterization of the neuroactive steroids 3-alpha-OH,5-alpha-pregnan-20-one and 3-alpha-OH,5-beta-pregnan-20-one in rodents. Psychopharmacology 1995; 118: 65–71
   PubMed Web of Science ®Google Scholar
• Winters W. D., Mori K., Spencer C. E., Bauer R. O. The neurophysiology of anesthesia. Anesthesiology 1967; 28: 65–80
   PubMed Web of Science ®Google Scholar
• Wise R. A. Action of drugs of abuse on brain reward systems. Pharmacol. Biochem. Behav. 1980; 12(Suppl.1)213–223
   PubMedGoogle Scholar
• Wise R. A., Bozarth M. A. A psychomotor stimulant theory of addiction. Psychol. Rev. 1987; 94: 469–492
   PubMed Web of Science ®Google Scholar
• Wise R. A., Dawson V. Diazepam-induced eating and lever-pressing for food in sated rats. J. Comp. Physiol. Psychol. 1974; 86: 930–941
   PubMed Web of Science ®Google Scholar
• Witkin J., Goldberg S. Effects of cocaine on locomotor activity and schedule-controlled behaviors of inbred rat strains. Pharmacol. Biochem. Behav. 1990; 37: 339–342
   PubMed Web of Science ®Google Scholar
• Zernig G., O'Laughlin I.A., Fibiger H. C. Nicotine and heroin augment cocaine-induced dopamine overflow in nucleus accumbens. Eur. J. Pharmacol. 1997; 337: 1–10
   PubMed Web of Science ®Google Scholar