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Review Articles

A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

, &
Pages 195-216 | Received 12 Apr 2017, Accepted 23 Oct 2017, Published online: 24 Nov 2017

References

  • Allran JW, Karasov WH. 2001. Effects of atrazine on embryos, larvae, and adults of anuran amphibians. Environ Toxicol Chem. 20:769–775.
  • Alzieu C. 2000. Impact of tributyltin on marine invertebrates. Ecotoxicology. 9:71–76.
  • Ankley GT, Giesy JP. (1998). Endocrine disruptors in wildlife: a weight-of-evidence perspective. In: Kendall R, Dickerson R, Giesy JP, Suk W, editors. Principles and processes for evaluating endocrine disruption in wildlife. Pensacola: SETAC Press; p. 349–367.
  • Aravindakshan J, Paquet V, Gregory M, Dufresne J, Fournier M, Marcogliese DJ, Cyr DG. 2004. Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius). Toxicol Sci. 78:156–165.
  • Bahamonde PA, Munkittrick KR, Martyniuk CJ. 2013. Intersex in teleost fish: are we distinguishing endocrine disruption from natural phenomena? Gen Comp Endocrinol. 192:25–35.
  • Baos R, Blas J, Bortolotti GR, Marchant TA, Hiraldo F. 2006. Adrenocortical response to stress and thyroid hormone status in free-living nestling white storks (Ciconia ciconia) exposed to heavy metal and arsenic contamination. Environ Health Perspect. 114:1497–1501.
  • Basu N, Scheuhammer AM, Bursian SJ, Elliott J, Rouvinen-Watt K, Chan HM. 2007. Mink as a sentinel species in environmental health. Environ Res. 103:130–144.
  • Bergman A. 1999. Health condition of the Baltic grey seal (Halichoerus grypus) during two decades. Gynaecological health improvement but increased prevalence of colonic ulcers. APMIS. 107:270–282.
  • Bergman Å, Becher G, Blumberg B, Bjerregaard P, Bornman R, Brandt I, Casey SC, Frouin H, Giudice LC, Heindel JJ, et al. 2015. Manufacturing doubt about endocrine disrupter science – a rebuttal of industry-sponsored critical comments on the UNEP/WHO report “State of the Science of Endocrine Disrupting Chemicals 2012”. Regul Toxicol Pharmacol. 73:1007–1017.
  • Bergman Å, Heindel JJ, Jobling S, Kidd KA, Zoeller RT, editors. (2012). State of the science of endocrine disrupting chemicals – 2012. Geneva: World Health Organization. p. 289.
  • Bergman Å, Olsson M. 1985. Pathology of Baltic grey seal and ringed seal females with special reference to adrenocortical hyperplasia: is environmental pollution the cause of a widely distributed disease syndrome? Finn Game Res. 44:47–62.
  • Biggers WJ, Laufer H. 2004. Identification of juvenile hormone-active alkylphenols in the lobster Homarus americanus and in marine sediments. Biol Bull. 206:13–24.
  • Birnbaum LS, Staskal DF. 2004. Brominated flame retardants: cause for concern? Environ Health Perspect. 112:9–17.
  • Bjorkblom C, Hogfors E, Salste L, Bergelin E, Olsson PE, Katsiadaki I, Wiklund T. 2009. Estrogenic and androgenic effects of municipal wastewater effluent on reproductive endpoint biomarkers in three-spined stickleback (Gasterosteus aculeatus). Environ Toxicol Chem. 28:1063–1071.
  • Blanton ML, Specker JL. 2007. The hypothalamic-pituitary-thyroid (HPT) axis in fish and its role in fish development and reproduction. Crit Rev Toxicol. 37:97–115.
  • Boas M, Feldt-Rasmussen U, Skakkebaek NE, Main KM. 2006. Environmental chemicals and thyroid function. Eur J Endocrinol. 154:599–611.
  • Bouchard B, Gagné F, Fortier M, Fournier M. 2009. An in-situ study of the impacts of urban wastewater on the immune and reproductive systems of the freshwater mussel Elliptio complanata. Comp Biochem Physiol C Toxicol Pharmacol. 150:132–140.
  • Bradford CM, Carr JA, Rinchard J, Theodorakis C. 2005. Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations. Environ Sci Technol. 39:5190–5195.
  • Brar NK, Waggoner C, Reyes JA, Fairey R, Kelley KM. 2010. Evidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures. Aquat Toxicol. 96:203–215.
  • Bryan GW, Gibbs PE. (1991). Impact of low concentrations of tributyltin (TBT) on marine organisms: a review. In: Newman MC, McIntosh AW, editors. Metal ecotoxicology: concepts and applications. Ann Arbor: Lewis Publishers; p. 323–361.
  • Caldwell DJ, Mastrocco F, Anderson PD, Länge R, Sumpter JP. 2012. Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol. Environ Toxicol Chem. 31:1396–1406.
  • Carr JA, Urquidi LJ, Goleman WL, Hu F, Smith NP, Theodorakis CW. (2003). Ammonium perchlorate disruption of thyroid function in natural amphibian populations: Assessment and potential impact. In: Krest S, Linder G, editors. Multiple stressor effects in relation to declining amphibian populations. West Conshohocken (PA): American Society for Testing and Materials, STP1443 STP11179S; p. 130–142.
  • Cesh LS, Elliott KH, Quade S, McKinney MA, Maisoneuve F, Garcelon DK, Sandau CD, Letcher RJ, Williams TD, Elliott JE. 2010. Polyhalogenated aromatic hydrocarbons and metabolites: relation to circulating thyroid hormone and retinol in nestling bald eagles (Haliaeetus leucocephalus). Environ Toxicol Chem. 29:1301–1310.
  • Chesman BS, Langston WJ. 2006. Intersex in the clam Scrobicularia plana: a sign of endocrine disruption in estuaries? Biol Lett. 2:420–422.
  • Coady K, Staples C, Losey B, Klecka G. 2010. A hazard assessment of aggregate exposure to nonylphenol and nonylphenol mono- and di-ethoxylates in the aquatic environment. Human Ecol Risk Assess. 16:1066–1094.
  • Crofton KM. 2008. Thyroid disrupting chemicals: mechanisms and mixtures. Int J Androl. 31:209–223.
  • Dawson A. 2000. Mechanisms of endocrine disruption with particular reference to occurrence in avian wildlife: a review. Ecotoxicology. 9:59–69.
  • De Metrio G, Corriero A, Desantis S, Zubani D, Cirillo F, Deflorio M, Bridges CR, Eicker J, de la Serna JM, Megalofonou P, et al. 2003. Evidence of a high percentage of intersex in the Mediterranean swordfish (Xiphias gladius L.). Mar Pollut Bull. 46:358–361.
  • De Mora S. (2009). Tributyltin: case study of an environmental contaminant. Cambridge (UK): Cambridge Environmental Chemistry Series, Cambridge University Press; 317 pp. ISBN: 978-0521470469.
  • Desforges JPW, Peachey BDL, Sanderson PM, White PA, Blais JM. 2010. Plasma vitellogenin in male teleost fish from 43 rivers worldwide is correlated with upstream human population size. Environ Pollut. 158:3279–3284.
  • De Swart RL, Ross PS, Vos JG, Osterhaus ADME. 1996. Impaired immunity in harbour seals (Phoca vitulina) exposed to bioaccumulated environmental contaminants: review of a long-term feeding study. Environ Health Perspect. 104:823–828.
  • deFur PL, Crane M, Ingersoll C, Tattersfield L. (1999). Endocrine disruption in invertebrates: endocrinology, testing, and assessment. Proceedings of the workshops on endocrine disruption in invertebrates; December 12–15 1998; Noordwijkerhout, The Netherlands. Pensacola, FL: SETAC Press.
  • Dods PL, Birmingham EM, Williams TD, Ikonomou MG, Bennie DT, Elliott JE. 2005. Reproductive success and contaminants in tree swallows (Tachycineta bicolor) breeding at a wastewater treatment plant. Environ Toxicol Chem. 24:3106–3112.
  • Du Preez LH, Kunene N, Everson GJ, Carr JA, Giesy JP, Gross TS, Hosmer AJ, Kendall RJ, Smith EE, Solomon KR, et al. 2008. Reproduction, larval growth, and reproductive development in African clawed frogs (Xenopus laevis) exposed to atrazine. Chemosphere. 71:546–552.
  • EFSA Panel on Plant Protection Products and their Residues 2013. Guidance on tiered risk assessment for plant protection products for aquatic organisms in edge-of-field surface waters. EFSA J. 11:3290.
  • EU. (2009). European Union Plant Protection Regulation, EC 1107/2009, Brussels.
  • EU. (2012). European Union Biocides Regulation, EC 528/2012, Brussels.
  • European Commission. (2002). Guidance Document on Aquatic Ecotoxicology in the context of the Directive 91/414/EEC (SANCO/3268/2001) rev.4 final, 17.11.2002, pp. 1–62.
  • Fossi MC, Marsili L. 2003. Effects of endocrine disruptors in aquatic mammals. Pure Appl Chem. 75:2235–2247.
  • Freyhof J, Kottelat M. (2008). Rutilus rutilus, The IUCN Red List of Threatened Species 2008. International Union for Conservation of Nature and Natural Resources. http://dx.doi.org/10.2305/IUCN.UK.2008.RLTS.T19787A9014741.en
  • Gagné F, Blaise C, Salazar M, Salazar S, Hansen PD. 2001. Evaluation of estrogenic effects of municipal effluents to the freshwater mussel Elliptio complanata. Comp Biochem Physiol. 128:213–225.
  • Gagné F, Bouchard B, André C, Farcy E, Fournier M. 2011. Evidence of feminization in wild Elliptio complanata mussels in the receiving waters downstream of a municipal effluent outfall. Comp Biochem Physiol. 153:99–106.
  • Game C, Gagnon MM, Webb D, Lim R. 2006. Endocrine disruption in male mosquitofish (Gambusia holbrooki) inhabiting wetlands in Western Australia. Ecotoxicology. 15:665–672.
  • Gentes ML, McNabb A, Waldner C, Smits JE. 2007. Increased thyroid hormone levels in tree swallows (Tachycineta bicolor) on reclaimed wetlands of the Athabasca oil sands. Arch Environ Contam Toxicol. 53:287–292.
  • Geraudie P, Gerbron M, Hill E, Minier C. 2010. Roach (Rutilus rutilus) reproductive cycle: a study of biochemical and histological parameters in a low contaminated site. Fish Physiol Biochem. 36:767–777.
  • Giesy JP, Kannan K. 2002. Perfluorochemical surfactants in the environment. Environ Sci Technol. 36:146–152.
  • Goleman WL, Urquidi LJ, Anderson TA, Smith EE, Kendall RJ, Carr JA. 2002. Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis. Environ Toxicol Chem. 21:590–597.
  • Grasman KA, Scanlon PF, Fox GA. 1998. Reproductive and physiological effects of environmental contaminants in fish-eating birds of the Great Lakes: a review of historical trends. Environ Monit Assess. 53:117–145.
  • Guillette LJ, Crain DA, Gunderson MP, Kools SAE, Milnes MR, Orlando EF, Rooney AA, Woodward AR. 2000. Alligators and endocrine disrupting contaminants: a current perspective. Am Zool. 40:438–452.
  • Hall AJ, Kalantzi OI, Thomas GO. 2003. Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life-are they thyroid hormone endocrine disrupters? Environ Pollut. 126:29–37.
  • Hamilton PB, Lange A, Nicol E, Bickley LK, De-Bastos ESR, Jobling S, Tyler CR. 2015. Effects of exposure to WwTW effluents over two generations on sexual development and breeding in roach Rutilus rutilus. Environ Sci Technol. 49:12994–13002.
  • Harris CA, Hamilton PB, Runnalls TJ, Vinciotti V, Henshaw A, Hodgson D, Coe TS, Jobling S, Tyler CR, Sumpter JP. 2011. The consequences of feminization in breeding groups of wild fish. Environ Health Perspect. 119:306–311.
  • Hashimoto S, Bessho H, Hara A, Nakamura M, Iguchi T, Fujita K. 2000. Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, Japan. Mar Environ Res. 49:37–53.
  • Hayes T, Collins A, Lee M, Mendoza M, Noriega N, Stuart A, Vonk A. 2002. Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proc Natl Acad Sci USA. 99:5476–5480.
  • Hayes T, Haston K, Tsui M, Hoang A, Haeffele C, Vonk A. 2003. Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. Environ Health Perspect. 111:568–575.
  • Hecker M, Giesy JP, Jones PD, Jooste AM, Carr JA, Solomon KR, Smith EE, Van Der Kraak G, Kendall RJ, du Preez L. 2004. Plasma sex steroid concentrations and gonadal aromatase activities in African clawed frogs (Xenopus laevis) from South Africa. Environ Toxicol Chem. 23:1996–2007.
  • Henny CJ, Grove RA, Kaiser JL, Johnson BL. 2010. North American osprey populations and contaminants: historic and contemporary perspectives. J Toxicol Environ Health. B Crit Rev. 13:579–603.
  • Hersikorn BD, Smits JEG. 2011. Compromised metamorphosis and thyroid hormone changes in wood frogs (Lithobates sylvaticus) raised on reclaimed wetlands on the Athabasca oil sands. Environ Pollut. 159:596–601.
  • Hill AB. 1965. The environment and disease; association or causation? J Roy Soc Med. 58:295–300.
  • Hontela A. 1998. Interrenal dysfunction in fish from contaminated sites: in vivo and in vitro assessment. Environ Toxicol Chem. 17:44–48.
  • Hontela A, Rasmussen JB, Audet C, Chevalier G. 1992. Impaired cortisol stress response in fish from environments polluted by PAHs, PCBs, and mercury. Arch Environ Contam Toxicol. 22:278–283.
  • Hopkins WA, Mendonca MT, Congdon JD. 1997. Increased circulating levels of testosterone and corticosterone in southern toads, Bufo terrestris, exposed to coal combustion waste. Gen Comp Endocrinol. 108:237–246.
  • Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DC. 2006. Biological monitoring of polyfluoroalkyl substances: a review. Environ Sci Technol. 40:3463–3473.
  • Ings JS, Servos MR, Vijayan MM. 2011. Exposure to municipal wastewater effluent impacts stress performance in rainbow trout. Aquat Toxicol. 103:85–91.
  • IPCS. (2002). Global assessment of the state-of-the-science of endocrine disruptors. International Programme on Chemical Safety, World Health Organisation, Geneva.
  • Irwin LK, Gray S, Oberdörster E. 2001. Vitellogenin induction in painted turtle, Chrysemys picta, as a biomarker of exposure to environmental levels of estradiol. Aquat Toxicol. 55:49–60.
  • Jepson PD, Deaville R, Barber JL, Aguilar A, Borrell A, Murphy S, Barry J, Brownlow A, Barnett J, Berrow S, et al. 2016. PCB pollution continues to impact populations of orcas and other dolphins in European waters. Sci Rep. 6.
  • Jepson PD, Law RJ. 2016. Persistent pollutants, persistent threats. Polychlorinated biphenyls remain a major threat to marine apex predators such as orcas. Science. 352:1388–1389.
  • Jobling S, Beresford N, Nolan M, Rodgers-Gray T, Brighty GC, Sumpter JP, Tyler CR. 2002a. Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol Reprod. 66:272–281.
  • Jobling S, Casey D, Rodgers-Gray T, Oehlmann J, Schulte-Oehlmann Pawlowski S, Baunbeck T, Turner AP, Tyler CR. 2004. Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol. 66:207–222.
  • Jobling S, Coey S, Whitmore JG, Kime DE, Van Look KJW, McAllister BG, Beresford N, Henshaw AC, Brighty G, Tyler CR, et al. 2002b. Wild intersex roach (Rutilus rutilus) have reduced fertility. Biol Reprod. 67:515–524.
  • Jobling S, Nolan M, Tyler CR, Brighty G, Sumpter JP. 1998. Widespread sexual disruption in wild fish. Environ Sci Technol. 32:2498–2506.
  • Jobling S, Sumpter J. 1993. Detergent components in sewage effluent are weakly oestrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol. 27:361–372.
  • Jobling S, Tyler CR. 2003. Endocrine disruption in wild freshwater fish. Pure Appl Chem. 75:2219–2234.
  • Jobling S, Williams R, Johnson A, Taylor A, Gross-Sorokin M, Nolan M, Tyler CR, van Aerle R, Santos E, Brighty G. 2006. Predicted exposures to steroid estrogens in UK rivers correlate with widespread sexual disruption in wild fish populations. Environ Health Perspect. 114:32–39.
  • Johnson AC, Chen Y. 2017. Does exposure to domestic wastewater effluent (including steroid estrogens) harm fish populations in the UK? Sci Tot Environ. 589:89–96.
  • Jooste AM, Du Preez LH, Carr JA, Giesy JP, Gross TS, Kendall RJ, Smith EE, Van Der Kraak GL, Solomon KR. 2005. Gonadal development of larval male Xenopus laevis exposed to atrazine in outdoor microcosms. Environ Sci Technol. 39:5255–5261.
  • Kakuta I. 2002. Interrenal stress responsiveness of marbled sole, Pleuronectes yokohamae, inhabiting Tokyo Bay. Environ Toxicol. 17:1–6.
  • Kavanagh RJ, Balch GC, Kiparissis Y, Niimi AJ, Sherry J, Tinson C, Metcalfe CD. 2004. Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes region. Environ Health Perspect. 112:898–902.
  • Khan AT, Weis JS 1993. Differential effects of organic and inorganic mercury on the micropyle of the eggs of Fundulus heteroclitus. Environ Biol Fishes. 37:323–327.
  • Kidd KA, Blanchfield PJ, Mills KH, Palace VP, Evans RE, Lazorchak JM, Flick RW. 2007. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci USA. 104:8897–8901.
  • Kidd KA, Paterson MJ, Rennie MD, Podemski CL, Findlay DL, Blanchfield PJ, Liber K. 2014. Direct and indirect responses of a freshwater food web to a potent synthetic oestrogen. Phil Trans Roy Soc B. 369.
  • Kirby MF, Allen YT, Dyer RA, Feist SW, Katsiadaki I, Matthiessen P, Scott AP, Smith A, Stentiford GD, Thain JE, et al. 2004. Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001. Environ Toxicol Chem. 23:748–758.
  • Klimisch HJ, Andreae M, Tillmann U. 1997. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul Toxicol Pharmacol. 25:1–5.
  • Kloas W, Lutz I, Springer T, Krueger H, Wolf J, Holden L, Hosmer A. 2009. Does atrazine influence larval development and sexual differentiation in Xenopus laevis? Toxicol Sci. 107:376–384.
  • Knight LA, Christenson MK, Trease AJ, Davis PH, Kolok AS. 2013. The spring runoff in Nebraska’s (USA) Elkhorn River watershed and its impact on two sentinel organisms. Environ Toxicol Chem. 32:1544–1551.
  • Knutson MG, Richardson WB, Reinecke DM, Gray BR, Parmelee JR, Weick SE. 2004. Agricultural ponds support amphibian populations. Ecol Applic. 14:669–684.
  • Körner O, Vermeirssen ELM, Burkhardt-Holm P. 2007. Reproductive health of brown trout inhabiting Swiss rivers with declining fish catch. Aquat Sci. 69:26–40.
  • Kortenkamp A, Evans R, Martin O, McKinlay R, Orton F, Rosivatz E. (2012). State of the art assessment of endocrine disrupters. Report to the European Commission, Brussels. 486 pp.
  • Kovarova J, Blahova J, Divisova L, Svobodova Z. 2013. Alkylphenol ethoxylates and alkylphenols – update information on occurrence, fate and toxicity in aquatic environment. Polish J Vet Sci. 16:763–772.
  • Kuiken T, Höfle U, Bennett PM, Allchin CR, Kirkwood JK, Baker JR, Appleby EC, Lockyer CH, Walton MJ, Sheldrick MC. 1993. Adrenocortical hyperplasia, disease and chlorinated hydrocarbons in the harbour porpoise (Phocoena phocoena). Mar Pollut Bull. 26:440–446.
  • Kulczykowska E, Kasprzak M, Kalamarz H, Kuriata M, Nietrzeba M, Jerzak L, Kaminski P. 2007. Melatonin and thyroxine response to pollution in white stork nestlings (Ciconia ciconia): aspects of rhythmicity and age. Comp Toxicol Pharmacol. 146:392–397.
  • Laflamme J-S, Couillard Y, Campbell PGC, Hontela A. 2000. Interrenal metallothionein and cortisol secretion in relation to Cd, Cu, and Zn exposure in yellow perch, Perca flavescens, from Abitibi lakes. Can J Fish Aquat Sci. 57:1672–1700.
  • Lair S, Béland P, De Guise S, Martineau D. 1997. Adrenal hyperplastic and degenerative changes in beluga whales. J Wildl Dis. 33:430–437.
  • Lange A, Paull GC, Hamilton PB, Iguchi T, Tyler CR. 2011. Implications of persistent exposure to treated wastewater effluent for breeding in wild roach (Rutilus rutilus) populations. Environ Sci Technol. 45:1673–1679. 7
  • Langlois VS, Carew AC, Pauli BD, Wade MG, Cooke GM, Trudeau VL. 2010. Low levels of the herbicide atrazine alters sex ratios and reduces metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms. Environ Health Perspect. 118:552–557.
  • Langston WJ, Burt GR, Chesman BS. 2007. Feminisation of male clams Scrobicularia plana from estuaries in southwest UK and its induction by endocrine-disrupting chemicals. Mar Ecol Prog Ser. 333:173–184.
  • Lawler SP, Jensen T, Dritz DA, Wichterman G. 1999. Field efficacy and nontarget effects of the mosquito larvicides temephos, methoprene, and Bacillus thuringiensis var. israelensis in Florida mangrove swamps. J Am Mosq Cont Assoc. 15:446–452.
  • Leatherland JF. 1998. Changes in thyroid hormone economy following consumption of environmentally contaminated Great Lakes fish. Toxicol Ind Health. 14:41–57.
  • Leusch FDL, Chapman HF, Kay GW, Gooneratne SR, Tremblay LA. 2006. Anal fin morphology and gonadal histopathology in mosquitofish (Gambusia holbrooki) exposed to treated municipal sewage effluent. Arch Environ Contam Toxicol. 50:562–574.
  • Lindstrom AB, Strynar MJ, Libelo EL. 2011. Polyfluorinated compounds: past, present, and future. Environ Sci Technol. 45:7954–7961.
  • Lundholm CE. 1997. DDE-induced eggshell thinning in birds: effects of p,p’-DDE on the calcium and prostaglandin metabolism of the eggshell gland. Comp Biol Physiol. 118C:113–128.
  • Matthiessen P. 2003. An historical perspective on endocrine disruption in wildlife. Pure Appl Chem. 75:2197–21206.
  • Matthiessen P. 2013. Detection, monitoring, and control of tributyltin-an almost complete success story. Environ Toxicol Chem. 32:487–489.
  • Matthiessen P, Gibbs PE. 1998. Critical appraisal of the evidence for tributyltin-mediated endocrine disruption in mollusks. Environ Toxicol Chem. 17:37–43.
  • Matthiessen P, Weltje L. 2015. A review of the effects of azole compounds in fish and their possible involvement in masculinization of wild fish populations. Crit Rev Toxicol. 45:453–467.
  • Mayne GJ, Martin PA, Bishop CA, Boermans HJ. 2004. Stress and immune responses of nestling tree swallows (Tachycineta bicolor) and eastern bluebirds (Sialia sialis) exposed to nonpersistent pesticides and p,p'-dichlorodiphenyldichloroethylene in apple orchards of southern Ontario, Canada. Environ Toxicol Chem. 23:2930–2940.
  • McCoy KA, Bortnick LJ, Campbell CM, Hamlin HJ, Guillette LJ, St Mary CM. 2008. Agriculture alters gonadal form and function in the toad Bufo marinus. Environ Health Perspect. 116:1526–1532.
  • McDaniel TV, Martin PA, Struger J, Sherry J, Marvin CH, McMaster ME, Clarence S, Tetreault G. 2008. Potential endocrine disruption of sexual development in free ranging male northern leopard frogs (Rana pipiens) and green frogs (Rana clamitans) from areas of intensive row crop agriculture. Aquat Toxicol. 88:230–242.
  • McKenney CL. 2005. The influence of insect juvenile hormone agonists on metamorphosis and reproduction in estuarine crustaceans. Integr Comp Biol. 45:97–105.
  • McNabb FMA, Fox GA. 2003. Avian thyroid development in chemically contaminated environments: is there evidence of alterations in thyroid function and development? Evol Dev. 5:76–82.
  • Miller LL, Rasmussen JB, Palace VP, Hontela A. 2009a. The physiological stress response and oxidative stress biomarkers in rainbow trout and brook trout from selenium-impacted streams in a coal mining region. J Appl Toxicol. 29:681–688.
  • Miller LL, Rasmussen JB, Palace VP, Hontela A. 2009b. Physiological stress response in white suckers from agricultural drain waters containing pesticides and selenium. Ecotox Environ Saf. 72:1249–1256.
  • Mills LJ, Chichester C. 2005. Review of evidence: are endocrine-disrupting chemicals in the aquatic environment impacting fish populations? Sci Tot Environ. 343:1–34.
  • Moore CG, Stevenson JM. 1991. The occurrence of intersexuality in harpacticoid copepods and its relationship with pollution. Mar Pollut Bull. 22:72–74.
  • Mosconi G, Di Rosa I, Bucci S, Morosi L, Franzoni MF, Polzonetti-Magni AM, Pascolini R. 2005. Plasma sex steroid and thyroid hormones profile in male water frogs of the Rana esculenta complex from agricultural and pristine areas. Gen Comp Endocrinol. 142:318–324.
  • Murk AJ, Boudewijn TJ, Meininger PL, Bosveld ATC, Rossaert G, Ysebaert T, Meire P, Dirksen S. 1996. Effects of polyhalogenated aromatic hydrocarbons and related contaminants on common tern reproduction: Integration of biological, biochemical, and chemical data. Arch Environ Contam Toxicol. 31:128–140.
  • Murphy MB, Hecker M, Coady KK, Tompsett AR, Higley EB, Jones PD, Du Preez LH, Solomon KR, Carr JA, Smith EE, et al. 2006a. Plasma steroid hormone concentrations, aromatase activities and GSI in ranid frogs collected from agricultural and non-agricultural sites in Michigan (USA). Aquat Toxicol. 77:153–166.
  • Murphy MB, Hecker M, Coady KK, Tompsett AR, Jones PD, D, Preez LH, Everson GJ, Solomon KR, Carr JA, Smith EE, et al. 2006b. Atrazine concentrations, gonadal gross morphology and histology in ranid frogs collected in Michigan agricultural areas. Aquat Toxicol. 76:230–245.
  • Nagler JJ, Bouma J, Thorgaard GH, Dauble DD. 2001. High incidence of a male-specific genetic marker in phenotypic female Chinook salmon from the Columbia River. Environ Health Perspect. 109:67–69.
  • Nice HE, Morritt D, Crane M, Thorndyke M. 2003. Long-term and transgenerational effects of nonylphenol exposure at a key stage in the development of Crassostrea gigas. Possible endocrine disruption? Mar Ecol Prog Ser. 256:293–300.
  • OECD. (2016). OECD Guidelines for the testing of chemicals. 2. Effects on biotic systems. Paris: Organisation for Economic Cooperation and Development. http://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-2-effects-on-biotic-systems_20745761
  • Oehlmann J, Di Benedetto P, Tillmann M, Duft M, Oetken M, Schulte-Oehlmann U. 2007. Endocrine disruption in prosobranch molluscs: evidence and ecological relevance. Ecotoxicology. 16:29–43.
  • Ortiz-Zarragoitia M, Cajaraville MP. 2010. Intersex and oocyte atresia in a mussel population from the Biosphere's Reserve of Urdaibai (Bay of Biscay). Ecotoxicol Environ Saf. 73:693–701.
  • Orton F, Carr JA, Handy RD. 2006. Effects of nitrate and atrazine on larval development and sexual differentiation in the Northern Leopard frog Rana pipiens. Environ Toxicol Chem. 25:65–71.
  • Pait AS, Nelson JO. (2002). Endocrine disruption in fish. An assessment of recent research and results. NOAA Technical Memorandum NOS NCCOS CCMA 149. Silver Spring, MD: NOAA, NOS, Center for Coastal Monitoring and Assessment. 55 pp.
  • Palace VP, Evans RE, Wautier K, Baron C, Vandenbyllardt L, Vandersteen W, Kidd K. 2002. Induction of vitellogenin and histological effects in wild fathead minnows from a lake experimentally treated with the synthetic estrogen ethynylestradiol. Water Qual Res J Can. 37:637–650.
  • Palace VP, Evans RE, Wautier KG, Mills KH, Blanchfield PJ, Park BJ, Baron CL, Kidd KA. 2009. Interspecies differences in biochemical, histopathological, and population responses in four wild fish species exposed to ethynylestradiol added to a whole lake. Can J Fish Aquat Sci. 66:1920–1935.
  • Pankhurst NW, Van Der Kraak G. 2000. Evidence that acute stress inhibits ovarian steroidogenesis in rainbow trout in vivo, through the action of cortisol. Gen Comp Endocrinol. 117:225–237.
  • Park BJ, Kidd K. 2005. Effects of the synthetic estrogen ethinylestradiol on early life stages of mink frogs and green frogs in the wild and in situ. Environ Toxicol Chem. 24:2027–2036.
  • Parrott J, Bjerregaard P, Brugger K, Gray LE, Iguchi T, Kadlec S, Weltje L, Wheeler J. 2017. Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances. Integr Environ Assess Manag. 13:293–301.
  • Peden-Adams MM, Keil DE, Romano T, Mollenhauer MAM, Fort DJ, Guiney PD, Houde M, Kannan K, Muir DC, Rice CD, et al. 2009. Health effects of perfluorinated compounds – what are the wildlife telling us? Reprod Toxicol. 27:414–415.
  • Pickford DB, Jones A, Velez-Pelez A, Iguchi T, Mitsui N, Tooi O. 2015. Screening breeding sites of the common toad (Bufo bufo) in England and Wales for evidence of endocrine disrupting activity. Ecotox Environ Saf. 117:7–19.
  • Porte C, Janer G, Lorusso LC, Ortiz-Zarragoitia M, Cajaraville MP, Fossi MC, Canesi L. 2006. Endocrine disruptors in marine organisms: Approaches and perspectives. Comp Toxicol Pharmacol. 143:303–315.
  • Pottinger TG. 2003. Interaction of endocrine-disrupting chemicals with stress responses in wildlife. Pure Appl Chem. 75:2321–2333.
  • Pottinger TG, Cook A, Jürgens MD, Rhodes G, Katsiadaki I, Balaam JL, Smith AJ, Matthiessen P. 2011. Effects of sewage effluent remediation on body size, somatic RNA: DNA ratio, and markers of chemical exposure in three-spined sticklebacks. Environ Int. 37:158–169.
  • Pottinger TG, Henrys PA, Williams RJ, Matthiessen P. 2013. The stress response of three-spined sticklebacks is modified in proportion to effluent exposure downstream of wastewater treatment works. Aquat Toxicol. 126:382–392.
  • Pottinger TG, Matthiessen P. 2016a. Disruption of the stress response in wastewater treatment works effluent-exposed three-spined sticklebacks persists after translocation to an unpolluted environment. Ecotoxicology. 25:538–547.
  • Pottinger TG, Matthiessen P. 2016b. Long-term water quality data explain inter-population variation in responsiveness to stress in sticklebacks at both wastewater effluent-contaminated and uncontaminated sites. Environ Toxicol Chem. 35:3014–3022.
  • Pottinger TG, Williams RJ, Matthiessen P. 2016. A comparison of two methods for the assessment of stress axis activity in wild fish in relation to wastewater effluent exposure. Gen Comp Endocrinol. 230:29–37.
  • Purdom CE, Hardiman PA, Bye VJ, Tyler C, Sumpter JP. 1994. Estrogenic effects of effluents from sewage treatment works. Chem Ecol. 8:275–285.
  • Quinn B, Gagné F, Costello M, McKenzie C, Wilson J, Mothersill C. 2004. The endocrine disrupting effect of municipal effluent on the zebra mussel (Dreissena polymorpha). Aquat Toxicol. 66:279–292.
  • Rasmussen JJ, Wiberg-Larsen P, Baatrup-Pedersen A, Cedergreen N, McKnight US, Kreuger J, Jacobsen D, Kristensen EA, Friberg N. 2015. The legacy of pesticide pollution: an overlooked factor in current risk assessments of freshwater systems. Water Res. 84:25–32.
  • Ratcliffe DA. 1967. Decrease in eggshell weight in certain birds of prey. Nature. 215:208–210.
  • Ratcliffe DA. 1970. Changes attributable to pesticides in egg breakage frequency and eggshell thickness in some British birds. J Appl Ecol. 7:67–115.
  • Reeder AL, Foley GL, Nichols DK, Hansen LG, Wikoff B, Faeh S, Eisold J, Wheeler MB, Warner R, Murphy JE, et al. 1998. Forms and prevalence of intersexuality and effects of environmental contaminants on sexuality in cricket frogs (Acris crepitans). Environ Health Perspect. 106:261–266.
  • Reeder AL, Ruiz MO, Pessier A, Brown LE, Levengood JM, Phillips CA, Wheeler MB, Warner RE, Beasley VR. 2005. Intersexuality and the cricket frog decline: historic and geographic trends. Environ Health Perspect. 113:261–265.
  • Robertson LW, Hansen LG (eds). (2001). PCBs: recent advances in environmental toxicology and health effects. University Press of Kentucky, Lexington. ISBN 0813122260
  • Rodgers-Gray TP, Jobling S, Kelly C, Morris S, Brighty G, Waldock MJ, Sumpter JP, Tyler CR. 2001. Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development. Environ Sci Technol. 35:462–470.
  • Russell TL, Kay BH, Skilleter GA. 2009. Environmental effects of mosquito larvicides on saltmarsh invertebrate fauna. Aquat Biol. 6:77–90.
  • Rutishauser BVM, Pesonen BI, Escher GE, Ackermann HR, Aerni M, Suter JF, Eggen RIL. 2004. Comparative analysis of estrogenic activity in sewage treatment plant effluents involving three in vitro assays and chemical analysis of steroids. Environ Toxicol Chem. 23:857–864.
  • Sangalang G, Jones G. 1997. Oocytes in testis and intersex in lobsters (Homarus americanus) from Nova Scotian sites: natural or site-related phenomenon? Can Tech Rep Fish Aquat Sci. 2163:46.
  • Scott AP. 2012. Do mollusks use vertebrate sex steroids as reproductive hormones? Part 1. Critical appraisal of the evidence for presence, biosynthesis and uptake of steroids. Steroids. 77:1450–1468.
  • Scott AP. 2013. Do mollusks use vertebrate sex steroids as reproductive hormones? Part 2. Critical review of the evidence that steroids have biological effects. Steroids. 78:268–281.
  • Scott AP, Katsiadaki I, Witthames PR, Hylland K, Davies IM, McIntosh AD, Thain J. 2006. Vitellogenin in the blood plasma of male cod (Gadus morhua): A sign of oestrogenic endocrine disruption in the open sea? Mar Environ Res. 61:149–170.
  • Scott AP, Sanders M, Stentiford GD, Reese RA, Katsiadaki I. 2007. Evidence for estrogenic endocrine disruption in an offshore flatfish, the dab (Limanda limanda L.). Mar Environ Res. 64:128–148.
  • Semlitsch RD, Scott DE, Pechmann JHK. 1988. Time and size at metamorphosis related to adult fitness in Ambystoma talpoideum. Ecology. 69:184–192.
  • Servos MR, Munkittrick KR, Carey JH, Van Der Kraak GJ. (eds). (1996). Environmental fate and effects of pulp and paper mill effluents. St Lucie Press, Florida, 703 pp.
  • Sheahan DA, Brighty GC, Daniel M, Jobling S, Harries JE, Hurst MR, Kennedy J, Kirby SJ, Morris S, Routledge EJ, et al. 2002. Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants. Environ Toxicol Chem. 21:515–519.
  • Smith EE, Du Preez LH, Gentles A, Solomon KR, Tandler B, Carr JA, Van Der Kraak GL, Kendall RJ, Giesy JP, Gross TS. 2005. Assessment of laryngeal muscle and testicular cell types in Xenopus laevis (Anura Pipidae) inhabiting maize and non-maize growing areas of South Africa. Afr J Herpet. 54:69–76.
  • Smith GM, Weis JS. 1997. Predator-prey relationships in mummichogs (Fundulus heteroclitus (L.)): effects of living in a polluted environment. J Exp Mar Biol Ecol. 209:75–87.
  • Sonne C. 2010. Health effects from long-range transported contaminants in Arctic top predators: an integrated review based on studies of polar bears and relevant model species. Environ Int. 36:461–491.
  • Sowers AD, Mills MA, Klaine SJ. 2009. The developmental effects of a municipal wastewater effluent on the northern leopard frog, Rana pipiens. Aquat Toxicol. 94:145–152.
  • Stock NL, Muir DCG, Mabury S. (2010). Perfluoroalkyl compounds. In: (Harrad S ed.) Persistent organic pollutants, pp. 25–69. Chichester, UK: John Wiley & Sons Ltd.
  • Tada N, Saka M, Shiraishi F, Kamata Y. 2007. A field study on serum vitellogenin levels in male Reeves' pond turtles (Chinemys reevesii) from estrogen-contaminated sites and a reference site. Sci Tot Environ. 384:205–213.
  • Theodorakis CW, Rinchard J, Carr JA, Park JW, Mcdaniel L, Liu FJ, Wages M. 2006. Thyroid endocrine disruption in stonerollers and cricket frogs from perchlorate-contaminated streams in east-central Texas. Ecotoxicology. 15:31–50.
  • Thorpe KL, Cummings RI, Hutchinson TH, Scholze M, Brighty G, Sumpter JP, Tyler CR. 2003. Relative potencies and combination effects of steroidal estrogens in fish. Environ Sci Technol. 37:1142–41149.
  • Tyler CR, Jobling S, Sumpter JP. 1998. Endocrine disruption in wildlife: a critical review of the evidence. Crit Rev Toxicol. 28:319–361.
  • USEPA. (2015). Endocrine Disruptor Screening Program. United States Environmental Protection Agency, Washington DC. http://www.epa.gov/endo
  • Vajda AM, Barber LB, Gray JL, Lopez EM, Woodling JD, Norris DO. 2008. Reproductive disruption in fish downstream from an estrogenic wastewater effluent. Environ Sci Technol. 42:3407–3414.
  • Van den Heuvel MR, Slade AH, Landman MJ. 2010. Summary of a decade of research on the effects of a New Zealand pulp and paper mill on reproduction in fishes. Water Qual Res J Can. 45:123–135.
  • Van Der Kraak G. 1998. Natural and anthropogenic environmental oestrogens: the scientific basis for risk assessment. Observations of endocrine effects in wildlife with evidence of their causation. Pure Appl Chem. 70:1785–1794.
  • Van Der Kraak GJ, Hosmer AJ, Hanson ML, Kloas W, Solomon KR. 2014. Effects of atrazine in fish, amphibians and reptiles: an analysis based on quantitative weight of evidence. Crit Rev Toxicol. 44:1–66.
  • Vethaak AD, Lahr J, Schrap SM, Belfroid AC, Rijs GBJ, Gerritsen A, de Boer J, Bulder AS, Grinwis GCM, Kuiper RV, et al. 2005. An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands. Chemosphere. 59:511–524.
  • Walker AN, Bush P, Puritz J, Wilson T, Chang ES, Miller T, Holloway K, Horst MN. 2005. Bioaccumulation and metabolic effects of the endocrine disruptor methoprene in the lobster, Homarus americanus. Integr Comp Biol. 45:118–126.
  • Wada H, Cristol DA, McNabb FMA, Hopkins WA. 2009. Suppressed adrenocortical responses and thyroid hormone levels in birds near a mercury-contaminated river. Environ Sci Technol. 43:6031–6038.
  • Weltje L. (2013). Techniques for measuring endocrine disruption in insects. In: Matthiessen P, editor. Endocrine disrupters: hazard testing and assessment methods, Chapter 4. Hoboken (NJ): John Wiley & Sons, Inc. p. 100–115.
  • Weltje L, Wheeler JR, Weyers A, Galay-Burgos M. 2013. Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology. Toxicol Lett. 223:291–294.
  • White JW, Cole BJ, Cherr GN, Connon RE, Brander SM. 2017. Scaling up endocrine disruption effects from individuals to populations: outcomes depend on how many males a population needs. Environ Sci Technol. 51:1802–1810.
  • WHO/IPCS (2002). Global assessment of the state of the science of endocrine disruptors. Damstra T, Barlow S, Bergman A, Kavlock R, Van Der Kraak G (eds). World Health Organisation/International Programme on Chemical Safety, Geneva, WHO/PCS/EDC/02.2.
  • Yogui GT, Sericano JL. 2009. Polybrominated diphenyl ether flame retardants in the US marine environment: a review. Environ Int. 35:655–666.
  • Zala SM, Penn DJ. 2004. Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges. Anim Behav. 68:649–664.
  • Zhou T, John-Alder HB, Weis JS, Weis P. 2000. Endocrine disruption: thyroid dysfunction in mummichogs (Fundulus heteroclitus) from a polluted habitat. Mar Environ Res. 50:393–397. 9
  • Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, Woodruff TJ, Von Saal FS. 2012. Endocrine-disrupting chemicals and public health protection: a statement of principles from the Endocrine Society. Endocrinology. 153:4097–4110.
  • Zoeller RT, Tan SW, Tyl RW. 2007. General background on the hypothalamic-pituitary-thyroid (HPT) axis . Crit Rev Toxicol. 37:11–53.