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Review Articles

Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances

, &
Pages 128-147 | Received 03 Jun 2019, Accepted 02 Dec 2019, Published online: 07 Feb 2020

References

  • Ahsan N, Ullah H, Ullah W, Jahan S. 2018. Comparative effects of Bisphenol S and Bisphenol A on the development of female reproductive system in rats; a neonatal exposure study. Chemosphere. 197:336–343.
  • Alabi A, Caballero-Casero N, Rubio S. 2014. Quick and simple sample treatment for multiresidue analysis of bisphenols, bisphenol diglycidyl ethers and their derivatives in canned food prior to liquid chromatography and fluorescence detection. J Chromatogr A. 1336:23–33.
  • Andra SS, Charisiadis P, Arora M, van Vliet-Ostaptchouk JV, Makris KC. 2015. Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environ Int. 85:352–379.
  • Andrianou XD, Gängler S, Piciu A, Charisiadis P, Zira C, Aristidou K, Piciu D, Hauser R, Makris KC. 2016. Human exposures to bisphenol A, bisphenol F and chlorinated bisphenol A derivatives and thyroid function. PLoS One. 11:e0155237.
  • ANSES. 2013a. Opinion of the French Agency for Food, Environmental and Occupational Health and Safety on the assessment of the risks associated with bisphenol A for human health, and on toxicological data and data on the use of bisphenols S, F, M, B, AP, AF and BADGE. https://www.anses.fr/en/system/files/CHIM2009sa0331Ra-0EN.PDF.
  • ANSES. 2013b. Substitution du bisphénol A. https://www.anses.fr/fr/system/files/CHIM2009sa0331Ra-3.pdf.
  • ANSES. 2014. OPINION of the French Agency for Food, Environmental and Occupational Health & Safety in response to the consultation of the European Food Safety Authority on its draft opinion regarding the assessment of risks to human health related to dietary exposure to Bisphenol A. Request no. 2014-SA-0033. https://www.anses.fr/en/system/files/SUBSTANCES2014sa0033EN.pdf.
  • ANSES. 2015. OPINION of the French Agency for Food, Environmental and Occupational Health & Safety regarding the solicited request 2015-SA-0001. Request No 2015-SA-0001. https://www.anses.fr/en/system/files/SUBCHIM2015sa0001EN.pdf.
  • ANSES. 2016a. Analysis of the most appropriate risk management option (RMOA). Substance name: 2,6-di-tert-butyl-p-cresol. EC Number: 204-881-4. CAS number: 128-37-0.
  • ANSES. 2016b. EXTRAIT DE L’AVIS du 17 février 2016 de l’Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail. 2015-SA-0117. https://www.anses.fr/fr/system/files/ESPA2015SA0117.pdf.
  • ANSES. 2017a. Analysis of the most appropriate risk management option (RMOA). Substance Name: 4, 4’-methylenedi-2,6-xylenol (TMBPF). EC Number: 226-378-9. CAS Number: 5384-21-4.
  • ANSES. 2017b. AVIS de l’Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail. 2017-SA-0117 and 2017-SA-0187. https://www.anses.fr/fr/system/files/REACH2017SA0117.pdf.
  • Ashby J, Lefevre P.A, Odum J, Tinwell H, Kennedy S.J, Beresford N, Sumpter J.P. 1997. Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents. Regulatory Toxicol Pharmacol. 26:96–101.
  • Bakker J, Hakkert B, Hessel E, Luit R, Piersma A, Sijm D, Rietveld DTHM, van Borekhuizen FA, Varhoeven JK. 2016. Bisphenol A Part 2. Recommendations for risk management. RIVM Rapport 2015-0192. http://wwwrivmnl/Documenten_en_publicaties/Wetenschappelijk/Rapporten/2016/maart/Bisphenol_A_Part_2_Recommendations_for_risk_management.
  • Bhunia K, Sablani SS, Tang J, Rasco B. 2013. Migration of chemical compounds from packaging polymers during microwave, conventional heat treatment, and storage. Comprehensive Rev Food Sci Food Saf. 12:523–545.
  • Bittner GD, Yang CZ, Stoner MA. 2014. Estrogenic chemicals often leach from BPA-free plastic products that are replacements for BPA-containing polycarbonate products. Environ Health. 13:41.
  • Bjornsdotter MK, de Boer J, Ballesteros-Gomez A. 2017a. Bisphenol A and replacements in thermal paper: a review. Chemosphere. 182:691–706.
  • Bjornsdotter MK, Jonker W, Legradi J, Kool J, Ballesteros-Gomez A. 2017b. Bisphenol A alternatives in thermal paper from the Netherlands, Spain, Sweden and Norway. Screening and potential toxicity. Sci Tot Environ. 601:210–221.
  • Boon PE, Biesebeek JDT, Brants H, Bouwmeester MC, Hessel EVS. 2018. Dietary sources of exposure to bisphenol A in the Netherlands. RIVM Letter report 2017-0187. https://www.rivm.nl/bibliotheek/rapporten/2017-0187.pdf
  • Brandsma SH, Sellström U, De Wit CA, De Boer J, Leonards P. 2013. Dust measurement of two organophosphorus flame retardants, resorcinol bis(diphenylphosphate) (RBDPP) and bisphenol A bis(diphenylphosphate) (BPA-BDPP), used as alternatives for BDE-209. Environ Sci Technol. 47:14434–14441.
  • Cao XL, Popovic S. 2015. Bisphenol A and three other bisphenol analogues in canned fish products from the Canadian market 2014. J Food Protect. 78:1402–1407.
  • Cariou R, Antignac JP, Zalko D, Berrebi A, Cravedi JP, Maume D, Marchand P, Monteau F, Riu A, Andre F, et al. 2008. Exposure assessment of French women and their newborns to tetrabromobisphenol-A: occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum. Chemosphere. 73:1036–1041.
  • Chen S, Chang Q, Yin K, He Q, Deng Y, Chen B, Liu C, Wang Y, Wang L. 2017. Rapid analysis of bisphenol A and its analogues in food packaging products by paper spray ionization mass spectrometry. J Agric Food Chem. 65:4859–4865.
  • Chen Y, Fang J, Ren L, Fan R, Zhang J, Liu G, Zhou L, Chen D, Yu Y, Lu S, et al. 2018. Urinary bisphenol analogues and triclosan in children from south China and implications for human exposure. Environmental Pollution. 238:299–305.
  • Cheng Y, Nie XM, Wu HQ, Hong YH, Yang BC, Liu T, Zhao D, Wang JF, Yao GH, Zhang F, et al. 2017. A high-throughput screening method of bisphenols, bisphenols digycidyl ethers and their derivatives in dairy products by ultra-high performance liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 950:98–107.
  • Conley JM, Hannas BR, Furr JR, Wilson VS, Gray LE Jr. 2016. A demonstration of the uncertainty in predicting the estrogenic activity of individual chemicals and mixtures from an in vitro estrogen receptor transcriptional activation assay (T47D-KBluc) to the in vivo uterotrophic assay using oral exposure. Toxicol Sci. 153:382–395.
  • Cope RB, Kacew S, Dourson M. 2015. A reproductive, developmental and neurobehavioral study following oral exposure of tetrabromobisphenol A on Sprague-Dawley rats. Toxicology. 329:49–59.
  • Danish EPA. 2014. Alternative technologies and substances to bisphenol A (BPA) in thermal paper receipts. Environmental project no 1553. Copenhagen: Danish EPA.
  • Deceuninck Y, Bichon E, Marchand P, Boquien CY, Legrand A, Boscher C, Antignac JP, Le Bizec B. 2015. Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry. Anal Bioanal Chem. 407:2485–2497.
  • Dopico-Garcia MS, Lopez-Vilarino JM, Gonzalez-Rodriguez MV. 2007. Antioxidant content of and migration from commercial polyethylene, polypropylene, and polyvinyl chloride packages. J Agric Food Chem. 55:3225–3231.
  • Dutch Inspectorate for Health Protection and Veterinary Public Health (VWA/KvW). 2005. Screening of plastic toys for chemical composition and hazards. Market surveillance in the Netherlands. Report no.: ND05o610/01.
  • ECHA. 2012. Committee for Risk Assessment RAC Opinion of the committee for risk assessment on a dossier proposing harmonised classification and labelling at the eu level of p-tert-butyphenol, EC number: 202-679-0, CAS number: 98-54-4. https://echa.europa.eu/documents/10162/e5388923-9221-c8d3-5ed2-3e61c1119288. Committee for Risk Assessment (RAC). Report no.: ECHA/RAC/CLH-O-0000002629-66-01/F.
  • ECHA. 2016a. Decision on substance evaluation pursuant to article 46(1) of regulation (EC) no 1907/2006 for 4,4’-sulfonyldiphenol, CAS No 80-09-1 (EC No 201-250-5). https://echa.europa.eu/documents/10162/776a7a2e-1526-430a-8630-70163473dfc0.
  • ECHA. 2016b. Decision on substance evaluation pursuant to article 46(1) of regulation (EC) no 1907/2006 for 4-tert-butyiphenol, CAS no 98-54-4 (EC no 202-679-0). https://echa.europa.eu/documents/10162/cb0eb400-5007-43b8-8d64-476059a56c4d.
  • ECHA. 2016c. Justification for the selection of a candidate CoRAP substance. Substance name (public name): 2,6-di-tert-butyl-p-cresol. CAS number: 128-37-0. https://echa.europa.eu/documents/10162/074c1b5b-d751-4e27-9e39-ae78743de03b.
  • ECHA. 2017. Inclusion of substances of very high concern in the candidate list for eventual inclusion in Annex XIV (Decision of the European Chemicals Agency). Report number ED/30/2017. https://echa.europa.eu/nl/candidate-list-table/-/dislist/details/0b0236e180e22414.
  • ECHA. 2018a. Inclusion of substances of very high concern in the Candidate List for eventual inclusion in Annex XIV (Decision of the European Chemicals Agency). Report number ED/01/2018. https://echa.europa.eu/nl/candidate-list-table/-/dislist/details/0b0236e180e22414.
  • ECHA. 2018b. Public activities coordination tool (PACT). https://echa.europa.eu/nl/pact.
  • ECHA. 2018c. ECHA database. http://www.echa.europa.eu/.
  • Eckardt M, Simat TJ. 2017. Bisphenol A and alternatives in thermal paper receipts - a German market analysis from 2015 to 2017. Chemosphere. 186:1016–1025.
  • EFSA. 2012. EFSA panel on food additives and nutrient sources added to food (ANS); scientific opinion on the reevaluation of butylated hydroxytoluene BHT (E 321) as a food additive. EFSA J. 10:2588.
  • EFSA, CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids). 2015. Scientific opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: part I – exposure assessment. EFSA J. 13:3978.
  • EFSA, Gundert-Remy U, Bodin J, Bosetti C, FitzGerald RE, Hanberg A, Hass U, Hooijmans C, Rooney AA, Rousselle C, van Loveren H, et al. 2017. Bisphenol A (BPA) hazard assessment protocol. EFSA Support Publications 14(12):EN–1354. https://doi.org/10.2903/sp.efsa.2017.en-1354
  • European Chemical Agency (ECHA); European Food Safety Authority (EFSA) with the technical support of the Joint Research Centre (JRC); Andersson N, Arena M, Auteri D, Barmaz S, Grignard E, Kienzler A, Lepper P, Lostia AM, Munn S, Morte JMP, Pellizzato F, Tarazona J, Terron A, Van der Linden S. 2018. Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009. EFSA J. 16:e05311.
  • European Union. 2006a. Regulation (EC) no. 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Off J Eur Union L396:1–849.
  • European Union. 2006b. Risk assessment report 2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol (CAS No. 79-94-7), Part II – human health. Final report.
  • Feng Y, Yin J, Jiao Z, Shi J, Li M, Shao B. 2012. Bisphenol AF may cause testosterone reduction by directly affecting testis function in adult male rats. Toxicol Lett. 211:201–209.
  • Gallart-Ayala H, Moyano E, Galceran MT. 2011. Analysis of bisphenols in soft drinks by on-line solid phase extraction fast liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 683:227–233.
  • Gezondheidsraad (Health Council of the Netherlands). 2014. Advisory letter: the health risks of bisphenol A analogues. Publication no 2014/06E.
  • Goldinger DM, Demierre AL, Zoller O, Rupp H, Reinhard H, Magnin R, Becker TW, Bourqui-Pittet M. 2015. Endocrine activity of alternatives to BPA found in thermal paper in Switzerland. Regulatory Toxicol Pharmacol. 71:453–462.
  • Grosse Y, Loomis D, Guyton KZ, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Mattock H, Straif K. 2016. Carcinogenicity of some industrial chemicals. Lancet Oncol. 17:419–420.
  • Heffernan A.L, Thompson K, Eaglesham G, Vijayasarathy S, Mueller J.F, Sly P.D, Gomez M.J. 2016. Rapid, automated online SPE-LC-QTRAP-MS/MS method for the simultaneous analysis of 14 phthalate metabolites and 5 bisphenol analogues in human urine. Talanta. 151:224–233.
  • Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, et al. 2015. NIEHS/FDA CLARITY-BPA research program update. Reprod Toxicol. (Elmsford, NY). 58:33–44.
  • Higashihara N, Shiraishi K, Miyata K, Oshima Y, Minobe Y, Yamasaki K. 2007. Subacute oral toxicity study of bisphenol F based on the draft protocol for the “Enhanced OECD Test Guideline no. 407. Arch Toxicol. 81:825–832.
  • Hormann AM, Vom Saal FS, Nagel SC, Stahlhut RW, Moyer CL, Ellersieck MR, Welshons WV, Toutain PL, Taylor JA. 2014. Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA). PLoS One. 9:e110509.
  • INERIS. n.d. [accessed 2018]. https://substitution-bp.ineris.fr/en.
  • Ji K, Hong S, Kho Y, Choi K. 2013. Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish. Environ Sci Technol. 47:8793–8800.
  • Jurek A, Leitner E. 2017. Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by GC-MS/MS. Food Addit Contaminants Part A Chem Anal Control Exposure Risk Assess. 34:1225–1238.
  • KEMI. 2017. Bisfenoler – en kartläggning och analys. [Summary in English, p 9.]. https://www.kemi.se/global/rapporter/2017/rapport-5-17-bisfenoler-en-kartlaggning-och-analys.pdf.
  • Kitamura S, Suzuki T, Sanoh S, Kohta R, Jinno N, Sugihara K, Yoshihara S, Fujimoto N, Watanabe H, Ohta S. 2005. Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds. Toxicol Sci. 84:249–259.
  • Li J, Sheng N, Cui R, Feng Y, Shao B, Guo X, Zhang H, Dai J. 2016. Gestational and lactational exposure to bisphenol AF in maternal rats increases testosterone levels in 23-day-old male offspring. Chemosphere. 163:552–561.
  • Liao C, Kannan K. 2013. Concentrations and profiles of bisphenol a and other bisphenol analogues in foodstuffs from the united states and their implications for human exposure. J Agric Food Chem. 61:4655–4662.
  • Liao C, Kannan K. 2014. A survey of bisphenol A and other bisphenol analogues in foodstuffs from nine cities in China. Food Additives Contaminants Part A Chem Anal Control Exposure Risk Assess. 31:319–329.
  • Liao C, Liu F, Guo Y, Moon HB, Nakata H, Wu Q, Kannan K. 2012. Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure. Environ Sci Technol. 46:9138–9145.
  • Liu B, Lehmler HJ, Sun Y, Xu G, Liu Y, Zong G, Sun Q, Hu FB, Wallace RB, Bao W, et al. 2017. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planetary Health 1:e114–e22.
  • Lu S, Yu Y, Ren L, Zhang X, Liu G, Yu Y. 2018. Estimation of intake and uptake of bisphenols and triclosan from personal care products by dermal contact. Sci Tot Environ. 621:1389–1396.
  • Naderi M, Wong MY, Gholami F. 2014. Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults. Aquat Toxicol. (Amsterdam, Netherlands). 148:195–203.
  • NTP. 2014. NTP technical report on the toxicology studies of tetrabromobisphenol a (CAS No. 79-94-7) in F344/NTac rats and B6C3F1/N Mice and toxicology and carcinogenesis studies of tetrabromobisphernol A in Wistar Han (Crl:WI(Han)) rats and B6C3F1/N mice (Gavage studies).
  • NTP. 2017. NTP research report on biological activity of bisphenol A (BPA) structural analogues and functional alternatives. NTP Research Report 4. Research Triangle Park, NC: National Toxicity Program. https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr04_508.pdf.
  • NTP. 2018. Draft NTP research report on the CLARITY-BPA core 22 study: a perinatal and chronic extended-dose-range study of bisphenol A in rats. Triangle Park (NC): National Toxicology Program Research. NTP RR 9.
  • OECD. 2013. Synthesis paper on per- and polyfluorinated chemicals (PFCs). Paris: Environment, Health and Safety, Environment Directorate, OECD.
  • OECD. 2018. Revised Guidance Document 150 on standardised test guidelines for evaluating chemicals for endocrine disruption. OECD Series on Testing and Assessment. Paris: OECD.
  • Olsen P, Meyer O, Bille N, Wurtzen G. 1986. Carcinogenicity study on butylated hydroxytoluene (BHT) in Wistar rats exposed in utero. Food Chem Toxicol. 24:1–12.
  • Onghena M, Van Hoeck E, Van Loco J, Ibáñez M, Cherta L, Portolés T, Pitarch E, Hernandéz F, Lemière F, Covaci A, et al. 2015. Identification of substances migrating from plastic baby bottles using a combination of low-resolution and high-resolution mass spectrometric analysers coupled to gas and liquid chromatography. J Mass Spectrom. 50:1234–1244.
  • Onghena M, van Hoeck E, Vervliet P, Scippo ML, Simon C, van Loco J, Covaci A. 2014. Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS. Food Additives Contaminants Part A Chem Anal Control Exposure Risk Assess. 31:2090–2102.
  • Owczarek K, Kubica P, Kudłak B, Rutkowska A, Konieczna A, Rachoń D, Namieśnik J, Wasik A. 2018. Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography-tandem mass spectrometry. Sci Tot Environ. 628:1362–1368.
  • Philips EM, Jaddoe VW.V, Asimakopoulos AG, Kannan K, Steegers EA.P, Santos S, Trasande L. 2018. Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004–5. Environ Res. 161:562–572.
  • Pivnenko K, Pedersen GA, Eriksson E, Astrup TF. 2015. Bisphenol A and its structural analogues in household waste paper. Waste Manage. 44:39–47.
  • Pop A, Berce C, Bolfa P, Nagy A, Catoi C, Dumitrescu IB, Silaghi-Dumitrescu L, Loghin F. 2013. Evaluation of the possible endocrine disruptive effect of butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate in immature female rats. Farmacia. 61:202–211.
  • Rocha BA, da Costa BRB, de Albuquerque NCP, de Oliveira ARM, Souza JMO, Al-Tameemi M, Campiglia AD, Barbosa F Jr. 2016. A fast method for bisphenol A and six analogues (S, F, Z, P, AF, AP) determination in urine samples based on dispersive liquid-liquid microextraction and liquid chromatography-tandem mass spectrometry. Talanta. 154:511–519.
  • Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ Health Perspect. 123:643–650.
  • Russo G, Barbato F, Grumetto L. 2017. Monitoring of bisphenol A and bisphenol S in thermal paper receipts from the Italian market and estimated transdermal human intake: a pilot study. Sci Tot Environ. 599:68–75.
  • SCCP. 2005. Opinion on benzoic acid and sodium benzoate. Report number SCCP/0891/05. http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_015.pdf.
  • SCENIHR. 2015. Final opinion on the safety of the use of bisphenol A in medical devices. [adopted 2015 February 18]. https://ec.europa.eu/health/scientific_committees/emerging/docs/scenihr_o_040.pdf.
  • Shi M, Sekulovski N, MacLean JA, Hayashi K. 2017. Effects of bisphenol A analogues on reproductive functions in mice. Reprod Toxicol. 73:280–291.
  • Shi M, Sekulovski N, MacLean JA, Hayashi K. 2018. Prenatal exposure to bisphenol A analogues on male reproductive functions in mice. Toxicol Sci. 163:620–631.
  • Siracusa JS, Yin L, Measel E, Liang S, Yu X. 2018. Effects of bisphenol A and its analogs on reproductive health: a mini review. Reprod Toxicol. (Elmsford, NY). 79:96–123.
  • Soto AM, Schaeberle C, Maier MS, Sonnenschein C, Maffini MV. 2017. Evidence of absence: estrogenicity assessment of a new food-contact coating and the bisphenol used in its synthesis. Environ Sci Technol. 51:1718–1726.
  • Sun C, Leong LP, Barlow PJ, Chan SH, Bloodworth BC. 2006. Single laboratory validation of a method for the determination of bisphenol A, bisphenol A diglycidyl ether and its derivatives in canned foods by reversed-phase liquid chromatography. J Chromatogr A. 1129:145–148.
  • Tanaka T, Oishi S, Takahashi O. 1993. Three generation toxicity study of butylated hydroxytoluene administered to mice. Toxicol Lett. 66:295–304.
  • The European Commission. 2009. Regulation (EC) no. 1223/2009 of the European parliament and of the council of 30 November 2009 on cosmetic products (recast) (Text with EEA relevance). Off J Eur Union L342:59–209.
  • The European Commission. 2011a. Commission implementing regulation (EU) No 321/2011 of 1 April 2011 amending Regulation (EU) no. 10/2011 as regards the restriction of use of Bisphenol A in plastic infant feeding bottles (Text with EEA relevance). Off J Eur Union L87:1–2.
  • The European Commission. 2011b. Commission regulation (EU) no. 10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food (Text with EEA relevance). Off J Eur Union L12:1–89.
  • The European Commission. 2016. Commission Regulation (EU) 2016/2235 of 12 December 2016 amending Annex XVII to Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) as regards bisphenol A (Text with EEA relevance). Off J Eur Union L337:3–5.
  • The European Commission. 2018. Commission regulation (EU) 2018/213 of 12 February 2018 on the use of bisphenol A in varnishes and coatings intended to come into contact with food and amending Regulation (EU) No 10/2011 as regards the use of that substance in plastic food contact materials (Text with EEA relevance). Off J Eur Union L41:6–12.
  • Tyl RW, Myers CB, Marr MC, Sloan CS, Castillo NP, Veselica M.M, Seely JC, Dimond SS, Van Miller JP, Shiotsuka RN, et al. 2008. Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. Toxicol Sci. 104:362–384.
  • Ullah A, Pirzada M, Jahan S, Ullah H, Shaheen G, Rehman H, Siddiqui MF, Butt MA. 2018. Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: comparative in vitro and in vivo studies on the sperms and testicular tissues of rats. Chemosphere. 209:508–516.
  • Ullah H, Jahan S, Ain QU, Shaheen G, Ahsan N. 2016. Effect of bisphenol S exposure on male reproductive system of rats: a histological and biochemical study. Chemosphere. 152:383–391.
  • US EPA. 2014. Bisphenol A alternatives in thermal paper (final report January 2014). Washington (DC): U.S. Environmental Protection Agency. https://www.epa.gov/sites/production/files/2014-05/documents/bpa_final.pdf.
  • Van der Ven LTM, Van de Kuil T, Verhoef A, Verwer CM, Lilienthal H, Leonards PEG, Schauer UMD, Cantón RF, Litens S, De Jong FH, et al. 2008. Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study. Toxicology. 245:76–89.
  • van Es DS. 2014. Analysis of alternatives for BPA in thermal paper. Wageningen: Wageningen UR Food & Biobased Research.
  • van Leeuwen SP, Bovee TF, Awchi M, Klijnstra MD, Hamers AR, Hoogenboom RL, Portier L, Gerssen A. 2019. BPA, BADGE and analogues: a new multi-analyte LC-ESI-MS/MS method for their determination and their in vitro (anti)estrogenic and (anti)androgenic properties. Chemosphere. 221:246–253.
  • Wang L, Liao C, Liu F, Wu Q, Guo Y, Moon HB, et al. 2012. Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three East Asian countries. Environ Sci Technol. 46:11584–11593.
  • Williams GM, Iatropoulos MJ, Whysner J. 1999. Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. Food Chem Toxicol. 37:1027–1038.
  • Wong YM, Li R, Lee CKF, Wan HT, Wong C. 2017. The measurement of bisphenol A and its analogues, perfluorinated compounds in twenty species of freshwater and marine fishes, a time-trend comparison and human health based assessment. Marine Pollut Bull. 124:743–752.
  • Yamasaki K, Noda S, Imatanaka N, Yakabe Y. 2004. Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity. Toxicol Lett. 146:111–120.
  • Yamasaki K, Takeyoshi M, Sawaki M, Imatanaka N, Shinoda K, Takatsuki M. 2003. Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals. Toxicology. 183:93–115.
  • Yang Y, Yu J, Yin J, Shao B, Zhang J. 2014. Molecularly imprinted solid-phase extraction for selective extraction of bisphenol analogues in beverages and canned food. J Agric Food Chem. 62:11130–11137.
  • Yang YJ, Lee SY, Kim KY, Hong YP. 2010. Acute testis toxicity of bisphenol a diglycidyl ether in Sprague-Dawley rats. J Prev Med Public Health. 43:131–137.
  • Yao Y, Shao Y, Zhan M, Zou X, Qu W, Zhou Y. 2018. Rapid and sensitive determination of nine bisphenol analogues, three amphenicol antibiotics, and six phthalate metabolites in human urine samples using UHPLC-MS/MS. Anal Bioanal Chem. 410:3871–3883.
  • Zhang Z, Hu Y, Guo J, Yu T, Sun L, Xiao X, Zhu D, Nakanishi T, Hiromori Y, Li J, et al. 2017. Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice. Nat Commun. 8:14585.

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