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Review Articles

Molecular and epigenetic modes of Fumonisin B1 mediated toxicity and carcinogenesis and detoxification strategies

ORCID Icon, ORCID Icon & ORCID Icon
Pages 76-94 | Received 22 Oct 2020, Accepted 21 Jan 2021, Published online: 19 Feb 2021

References

  • Abado-Becognee K, Mobio TA, Ennamany R, Fleurat-Lessard F, Shier WT, Badria F, Creppy EE. 1998. Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses. Arch Toxicol. 72(4):233–236.
  • Abbès S, Ben Salah-Abbès J, Jebali R, Younes RB, Oueslati R. 2016. Interaction of aflatoxin B1 and fumonisin B1 in mice causes immunotoxicity and oxidative stress: possible protective role using lactic acid bacteria. J Immunotoxicol. 13(1):46–54.
  • Abdellatef AA, Khalil AA. 2016. Ameliorated effects of Lactobacillus delbrueckii subsp. lactis DSM 20076 and Pediococcus acidilactici NNRL B-5627 on fumonisin B1-induced hepatotoxicity and nephrotoxicity in rats. Asian J Pharm Sci. 11(2):326–336.
  • Abel S, Gelderblom WCA. 1998. Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo. Toxicology. 131 (2–3):121–131.
  • Alberts J, Rheeder J, Gelderblom W, Shephard G, Burger H-M. 2019. Rural subsistence maize farming in South Africa: risk assessment and intervention models for reduction of exposure to fumonisin mycotoxins. Toxins. 11(6):334.
  • Alizadeh AM, Rohandel G, Roudbarmohammadi S, Roudbary M, Sohanaki H, Ghiasian SA, Taherkhani A, Semnani S, Aghasi M. 2012. Fumonisin B1 contamination of cereals and risk of esophageal cancer in a high risk area in northeastern Iran. Asian Pac J Cancer Prev. 13(6):2625–2628.
  • Andreyev AY, Kushnareva YE, Starkov A. 2005. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc).70(2):200–214.
  • Arumugam T, Ghazi T, Chuturgoon A. 2020. Fumonisin B1 epigenetically regulates PTEN expression and modulates DNA damage checkpoint regulation in HepG2 liver cells. Toxins. 12(10):625.
  • Arumugam T, Pillay Y, Ghazi T, Nagiah S, Abdul NS, Chuturgoon AA. 2019. Fumonisin B1-induced oxidative stress triggers Nrf2-mediated antioxidant response in human hepatocellular carcinoma (HepG2) cells. Mycotoxin Res. 35(1):99–109.
  • Atroshi F, Rizzo A, Biese I, Veijalainen P, Saloniemi H, Sankari S, Andersson K. 1999. Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with coenzyme Q10, l-carnitine, alpha-tocopherol and selenium. Pharmacol Res. 40(6):459–467.
  • Ayala A, Munoz MF, Arguelles S. 2014. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014:360438.
  • Bernabucci U, Colavecchia L, Danieli PP, Basiricò L, Lacetera N, Nardone A, Ronchi B. 2011. Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. Toxicol In Vitro. 25(3):684–691.
  • Bhandari N, Brown CC, Sharma RP. 2002. Fumonisin B1-induced localized activation of cytokine network in mouse liver. Food Chem Toxicol. 40(10):1483–1491.
  • Bhandari N, He Q, Sharma RP. 2001. Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice. Toxicology. 165(2–3):195–204.
  • Bratic A, Larsson N-G. 2013. The role of mitochondria in aging. J Clin Invest. 123(3):951–957.
  • Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, et al. 2013. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol. 301:215–290.
  • Breslow DK, Weissman JS. 2010. Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell. 40(2):267–279.
  • Ceriello A, Motz E. 2004. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol. 24(5):816–823.
  • Chakrabarti A, Chen AW, Varner JD. 2011. A review of the mammalian unfolded protein response. Biotechnol Bioeng. 108(12):2777–2793.
  • Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9(6):7204–7218.
  • Chen C, Mitchell NJ, Gratz J, Houpt ER, Gong Y, Egner PA, Groopman JD, Riley RT, Showker JL, Svensen E, et al. 2018. Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania. Environ Int. 115:29–37.
  • Chlebicz A, Śliżewska K. 2020. In vitro detoxification of aflatoxin B1, deoxynivalenol, fumonisins, T-2 toxin and zearalenone by probiotic bacteria from genus Lactobacillus and Saccharomyces cerevisiae yeast. Probiotics Antimicrob Proteins. 12(1):289–301.
  • Chuturgoon A, Phulukdaree A, Moodley D. 2014a. Fumonisin B1 induces global DNA hypomethylation in HepG2 cells – an alternative mechanism of action. Toxicology. 315:65–69.
  • Chuturgoon AA, Phulukdaree A, Moodley D. 2014b. Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. Toxicol Lett. 227(1):50–55.
  • Chuturgoon AA, Phulukdaree A, Moodley D. 2015. Fumonisin B1 inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2. Toxicol Lett. 235(2):67–74.
  • Collins LJ, Schönfeld B, Chen XS. 2011. The epigenetics of non-coding RNA. In: Tollefsbol T, editor. Handbook of epigenetics. New York: Elsevier.
  • Collins TFX, Sprando RL, Black TN, Olejnik N, Eppley RM, Shackelford ME, Howard PC, Rorie JI, Bryant M, Ruggles DI. 2006. Effects of aminopentol on in utero development in rats. Food Chem Toxicol. 44(2):161–169.
  • Conlon KC, Miljkovic MD, Waldmann TA. 2019. Cytokines in the treatment of cancer. J Interferon Cytokine Res. 39(1):6–21.
  • Cosgrove MS, Boeke JD, Wolberger C. 2004. Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol. 11(11):1037–1043.
  • Dalle-Donne I, Aldini G, Carini M, Colombo R, Rossi R, Milzani A. 2006. Protein carbonylation, cellular dysfunction, and disease progression. J Cell Mol Med. 10(2):389–406.
  • De Girolamo A, Lattanzio VMT, Schena R, Visconti A, Pascale M. 2016. Effect of alkaline cooking of maize on the content of fumonisins B1 and B2 and their hydrolysed forms. Food Chem. 192:1083–1089.
  • Dellafiora L, Galaverna G, Dall'Asta C. 2018. Mechanisms of fumonisin B1 toxicity: a computational perspective beyond the ceramide synthases inhibition. Chem Res Toxicol. 31(11):1203–1212.
  • Demirel G, Alpertunga B, Ozden S. 2015. Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells. Pharm Biol. 53(9):1302–1310.
  • Denli M, Blandon JC, Salado S, Guynot ME, Casas J, Pérez JF. 2015. Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats. Food Chem Toxicol. 78:60–63.
  • Devriendt B, Gallois M, Verdonck F, Wache Y, Bimczok D, Oswald IP, Goddeeris BM, Cox E. 2009. The food contaminant fumonisin B(1) reduces the maturation of porcine CD11R1(+) intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection. Vet Res. 40(4):40.
  • Domijan AM, Abramov AY. 2011. Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—implication to mechanism of cell toxicity. Int J Biochem Cell Biol. 43(6):897–904.
  • Domijan AM, Peraica M, Vrdoljak AL, Radić B, Zlender V, Fuchs R. 2007. The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats. Mol Nutr Food Res. 51(9):1147–1151.
  • Domijan A, Zeljezic D, Peraica M, Kovacevic G, Gregorovic G, Krstanac Z, Horvatin K, Kalafatic M. 2008. Early toxic effects of fumonisin B1 in rat liver. Hum Exp Toxicol. 27(12):895–900.
  • Ehrlich V, Darroudi F, Uhl M, Steinkellner H, Zsivkovits M, Knasmueller S. 2002. Fumonisin B(1) is genotoxic in human derived hepatoma (HepG2) cells. Mutagenesis. 17(3):257–260.
  • Emerit J, Edeas M, Bricaire F. 2004. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 58(1):39–46.
  • Esteller M. 2007. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet. 8(4):286–298.
  • Ferrigo D, Raiola A, Causin R. 2016. Fusarium toxins in cereals: occurrence, legislation, factors promoting the appearance and their management. Molecules. 21(5):627.
  • FOA/WHO. 2002. Evaluation of certain mycotoxins in food: fifty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva: World Health Organization.
  • Futerman AH, Riezman H. 2005. The ins and outs of sphingolipid synthesis. Trends Cell Biol. 15(6):312–318.
  • Galvano F, Russo A, Cardile V, Galvano G, Vanella A, Renis M. 2002. DNA damage in human fibroblasts exposed to fumonisin B(1). Food Chem Toxicol. 40(1):25–31.
  • Gardner NM, Riley RT, Showker JL, Voss KA, Sachs AJ, Maddox JR, Gelineau-van Waes JB. 2016. Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. Toxicol Appl Pharmacol. 298:56–65.
  • Gazzotti T, Lugoboni B, Zironi E, Barbarossa A, Serraino A, Pagliuca G. 2009. Determination of fumonisin B1 in bovine milk by LC–MS/MS. Food Control. 20(12):1171–1174.
  • Gelderblom W, Jaskiewicz K, Marasas W, Thiel P, Horak R, Vleggaar R, Kriek N. 1988. Fumonisins—novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol. 54(7):1806–1811.
  • Gelderblom WCA, Kriek NPJ, Marasas WFO, Thiel PG. 1991. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis. 12(7):1247–1251.
  • Gelderblom W, Snyman S, Abel S, Lebepe-Mazur S, Smuts C, Van der Westhuizen L, Marasas W, Victor T, Knasmüller S, Huber W. 1996. Hepatotoxicity and -carcinogenicity of the fumonisins in rats. In: Jackson LS, DeVries JW, Bullerman LB, editors. Fumonisins in food. Springer.
  • Gelderblom WCA, Marasas WFO, Lebepe-Mazur S, Swanevelder S, Vessey CJ, de la M Hall P. 2002. Interaction of fumonisin B(1) and aflatoxin B(1) in a short-term carcinogenesis model in rat liver. Toxicology. 171(2–3):161–173.
  • Gelineau-van Waes J, Rainey MA, Maddox JR, Voss KA, Sachs AJ, Gardner NM, Wilberding JD, Riley RT. 2012. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. Birth Defects Res A Clin Mol Teratol. 94(10):790–803.
  • Glick D, Barth S, Macleod KF. 2010. Autophagy: cellular and molecular mechanisms. J Pathol. 221(1):3–12.
  • Goldberg AD, Allis CD, Bernstein E. 2007. Epigenetics: a landscape takes shape. Cell. 128(4):635–638.
  • Gonos ES, Kapetanou M, Sereikaite J, Bartosz G, Naparło K, Grzesik M, Sadowska-Bartosz I. 2018. Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging. Aging (Albany, NY). 10(5):868–901.
  • Gu MJ, Han SE, Hwang K, Mayer E, Reisinger N, Schatzmayr D, Park B-C, Han SH, Yun C-H. 2019. Hydrolyzed fumonisin B1 induces less inflammatory responses than fumonisin B1 in the co-culture model of porcine intestinal epithelial and immune cells. Toxicol Lett. 305:110–116.
  • Guerrero-Hernandez A, Dagnino-Acosta A, Verkhratsky A. 2010. An intelligent sarco-endoplasmic reticulum Ca2+ store: release and leak channels have differential access to a concealed Ca2+ pool. Cell Calcium. 48(2–3):143–149.
  • Hahn I, Nagl V, Schwartz-Zimmermann HE, Varga E, Schwarz C, Slavik V, Reisinger N, Malachová A, Cirlini M, Generotti S, et al. 2015. Effects of orally administered fumonisin B1 (FB1), partially hydrolysed FB1, hydrolysed FB1 and N-(1-deoxy-d-fructos-1-yl) FB1 on the sphingolipid metabolism in rats. Food Chem Toxicol. 76:11–18.
  • Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. 2003. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 426(6968):803–809.
  • Hannun YA, Obeid LM. 2008. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 9(2):139–150.
  • Hard GC, Howard PC, Kovatch RM, Bucci TJ. 2001. Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor. Toxicol Pathol. 29(3):379–386.
  • Harrer H, Humpf HU, Voss KA. 2015. In vivo formation of N-acyl-fumonisin B1. Mycotoxin Res. 31(1):33–40.
  • Harrer H, Laviad EL, Humpf HU, Futerman AH. 2013. Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins. Mol Nutr Food Res. 57(3):516–522.
  • Hassan AM, Abdel-Aziem SH, El-Nekeety AA, Abdel-Wahhab MA. 2015. Panax ginseng extract modulates oxidative stress, DNA fragmentation and up-regulate gene expression in rats sub chronically treated with aflatoxin B1 and fumonisin B 1. Cytotechnology. 67(5):861–871.
  • He Q, Suzuki H, Sharma N, Sharma RP. 2006. Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Toxicol Sci. 94(2):388–397.
  • Hebert DN, Molinari M. 2007. In and out of the ER: protein folding, quality control, degradation, and related human diseases. Physiol Rev. 87(4):1377–1408.
  • Heinl S, Hartinger D, Thamhesl M, Vekiru E, Krska R, Schatzmayr G, Moll W-D, Grabherr R. 2010. Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes. J Biotechnol. 145(2):120–129.
  • Hendrich S, Miller KA, Wilson TM, Murphy PA. 1993. Toxicity of Fusarium proliferatum-fermented nixtamalized corn-based diets fed to rats: effect of nutritional status. J Agric Food Chem. 41(10):1649–1654.
  • Hendricks K. 1999. Fumonisins and neural tube defects in south Texas. Epidemiology. 10(2):198–200.
  • Herman JG, Baylin SB. 2003. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 349(21):2042–2054.
  • Howard PC, Couch LH, Patton RE, Eppley RM, Doerge DR, Churchwell MI, Marques MM, Okerberg CV. 2002. Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice. Toxicol Appl Pharmacol. 185(3):153–165.
  • Howard P, Eppley R, Stack M, Warbritton A, Voss K, Lorentzen R, Kovach R, Bucci T. 1999. Carcinogenicity of fumonisin B1 in a two-year bioassay with Fischer 344 rats and B6C3F1 mice. Proc Jpn Assoc Mycotoxicol. 1999(Suppl. 2):45–54.
  • Howard PC, Warbritton A, Voss KA, Lorentzen RJ, Thurman JD, Kovach RM, Bucci TJ. 2001. Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat. Environ Health Perspect. 109(Suppl. 2):309–314.
  • Huang D, Cui L, Sajid A, Zainab F, Wu Q, Wang X, Yuan Z. 2019. The epigenetic mechanisms in Fusarium mycotoxins induced toxicities. Food Chem Toxicol. 123:595–601.
  • Huang HC, Nguyen T, Pickett CB. 2002. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem. 277(45):42769–42774.
  • Hullar MAJ, Burnett-Hartman AN, Lampe JW. 2014. Gut microbes, diet, and cancer. Cancer Treat Res. 159:377–399.
  • Humpf H-U, Schmelz E-M, Meredith FI, Vesper H, Vales TR, Wang E, Menaldino DS, Liotta DC, Merrill AH. 1998. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. J Biol Chem. 273(30):19060–19064.
  • IARC. 2002. Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. IARC Monogr Eval Carcinog Risks Hum. 82:1–556.
  • Jackson L, Voss K, Ryu D. 2012. Effects of different extrusion conditions on the chemical and toxicological fate of fumonisin B1 in maize: a short review. World Mycotoxin J. 5(3):251–260.
  • Jacquemyn J, Cascalho A, Goodchild RE. 2017. The ins and outs of endoplasmic reticulum-controlled lipid biosynthesis. EMBO Rep. 18(11):1905–1921.
  • Jebali A, Ardakani SAY, Shahdadi H, Zadeh MHB, Hekmatimoghaddam S. 2015. Modification of nanocellulose by poly-lysine can inhibit the effect of fumonisin B1 on mouse liver cells. Colloids Surf B Biointerfaces. 126:437–443.
  • Jiménez-Rojo N, Sot J, Busto JV, Shaw WA, Duan J, Merrill AH Jr, Alonso A, Goñi FM. 2014. Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophys J. 107(12):2850–2859.
  • Jones PA, Baylin SB. 2002. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 3(6):415–428.
  • Jones PA, Baylin SB. 2007. The epigenomics of cancer. Cell. 128(4):683–692.
  • Jones PA, Takai D. 2001. The role of DNA methylation in mammalian epigenetics. Science. 293(5532):1068–1070.
  • Kabir M, Kim HR, Chae H-J. 2018. Endoplasmic reticulum stress and autophagy.
  • Karuna R, Rao BS. 2013. Lack of micronuclei induction by fumonisin B(1) mycotoxin in BALB/c mice. Mycotoxin Res. 29(1):9–15.
  • Kellerman TS, Marasas WFO, Pienaar J, Naudé T. 1972. A mycotoxicosis of equidae caused by Fusarium moniliforme sheldon. A preliminary communication. Onderstepoort J Vet Res. 39(4):205–208.
  • Khalil AA, Abou-Gabal AE, Abdellatef AA, Khalid AE. 2015. Protective role of probiotic lactic acid bacteria against dietary fumonisin B1-induced toxicity and DNA-fragmentation in Sprague-Dawley rats. Prep Biochem Biotechnol. 45(6):530–550.
  • Khan RB, Phulukdaree A, Chuturgoon AA. 2018. Fumonisin B1 induces oxidative stress in oesophageal (SNO) cancer cells. Toxicon. 141:104–111.
  • Kim SH, Singh MP, Sharma C, Kang SC. 2018. Fumonisin B1 actuates oxidative stress-associated colonic damage via apoptosis and autophagy activation in murine model. J Biochem Mol Toxicol. 32(7):e22161.
  • Kimanya ME, Meulenaer BD, Baert K, Tiisekwa B, Van Camp J, Samapundo S, Lachat C, Kolsteren P. 2009. Exposure of infants to fumonisins in maize-based complementary foods in rural Tanzania. Mol Nutr Food Res. 53(5):667–674.
  • Kitatani K, Idkowiak-Baldys J, Hannun YA. 2008. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal. 20(6):1010–1018.
  • Koch GL. 1990. The endoplasmic reticulum and calcium storage. Bioessays. 12(11):527–531.
  • Kouadio JH, Dano SD, Moukha S, Mobio TA, Creppy EE. 2007. Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. Toxicon. 49(3):306–317.
  • Kouadio JH, Mobio TA, Baudrimont I, Moukha S, Dano SD, Creppy EE. 2005. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology. 213(1–2):56–65.
  • Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T. 2007. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 14(2):230–239.
  • Kriek NP, Kellerman TS, Marasas WF. 1981. A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. Onderstepoort J Vet Res. 48(2):129–131.
  • Kriek NPJ, Marasas WFO, Thiel PG. 1981. Hepato- and cardiotoxicity of Fusarium verticillioides (F. moniliforme) isolates from Southern African maize. Food Cosmet Toxicol. 19:447–456.
  • Kwon D, Kim S-M, Correia MA. 2020. Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. Acta Pharm Sin B. 10(1):42–60.
  • Lee HJ, Ryu D. 2017. Worldwide occurrence of mycotoxins in cereals and cereal-derived food products: public health perspectives of their co-occurrence. J Agric Food Chem. 65(33):7034–7051.
  • Lépine S, Allegood J, Park M, Dent P, Milstien S, Spiegel S. 2011. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death Differ. 18(2):350–361.
  • Li Y, Guo Y, Tang J, Jiang J, Chen Z. 2014. New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochim Biophys Sin (Shanghai). 46(8):629–640.
  • Liao Y-J, Yang J-R, Chen S-E, Wu S-J, Huang S-Y, Lin J-J, Chen L-R, Tang P-C. 2014. Inhibition of fumonisin B1 cytotoxicity by nanosilicate platelets during mouse embryo development. PLoS One. 9(11):e112290.
  • Linder B, Kögel D. 2019. Autophagy in cancer cell death. Biology (Basel). 8:82.
  • Liu X, Zhang E, Yin S, Zhao C, Fan L, Hu H. 2020. Activation of the IRE1α arm, but not the PERK arm, of the unfolded protein response contributes to fumonisin B1-induced hepatotoxicity. Toxins. 12(1):55.
  • Loft S, Høgh Danielsen P, Mikkelsen L, Risom L, Forchhammer L, Møller P. 2008. Biomarkers of oxidative damage to DNA and repair. Biochem Soc Trans. 36(Pt 5):1071–1076.
  • Ma Q. 2013. Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 53:401–426.
  • Maceyka M, Payne SG, Milstien S, Spiegel S. 2002. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta. 1585(2–3):193–201.
  • Magan N, Medina A, Aldred D. 2011. Possible climate-change effects on mycotoxin contamination of food crops pre- and postharvest. Plant Pathol. 60(1):150–163.
  • Mahmoodi M, Alizadeh AM, Sohanaki H, Rezaei N, Amini-Najafi F, Khosravi AR, Hosseini SK, Safari Z, Hydarnasab D, Khori V. 2012. Impact of fumonisin B1 on the production of inflammatory cytokines by gastric and colon cell lines. Iran J Allergy Asthma Immunol. 11:165–173.
  • Marasas W. 2001. Discovery and occurrence of the fumonisins: a historical perspective. Environ Health Perspect. 109:239–243.
  • Marasas WF, Kriek NP, Fincham JE, Van Rensburg SJ. 1984. Primary liver cancer and oesophageal basal cell hyperplasia in rats caused by Fusarium moniliforme. Int J Cancer. 34(3):383–387.
  • Marasas W, Wehner F, Van Rensburg S, Van Schalkwyk D. 1981. Mycoflora of corn produced in human esophageal cancer areas in Transkei, southern Africa. Phytopathology. 71:792–796.
  • Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, et al. 2013. XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J Biol Chem. 288(2):859–872.
  • Marin DE, Gouze M-E, Taranu I, Oswald IP. 2007. Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells. Mol Nutr Food Res. 51(11):1406–1412.
  • Martinova EA, Merrill AH. 1995. Fumonisin B1 alters sphingolipid metabolism and immune function in BALB/c mice: immunological responses to fumonisin B1. Mycopathologia. 130(3):163–170.
  • Mary VS, Theumer MG, Arias SL, Rubinstein HR. 2012. Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells. Toxicology. 302(2–3):299–307.
  • Masching S, Naehrer K, Schwartz-Zimmermann H-E, Sărăndan M, Schaumberger S, Dohnal I, Nagl V, Schatzmayr D. 2016. Gastrointestinal degradation of fumonisin B1 by carboxylesterase FumD prevents fumonisin induced alteration of sphingolipid metabolism in turkey and swine. Toxins. 8(3):84.
  • Mboya R, Kolanisi U. 2014. Subsistence farmers’ mycotoxin contamination awareness in the SADC region: implications on millennium development goal 1, 4 and 6. J Hum Ecol. 46(1):21–31.
  • Merrill AH Jr, van Echten G, Wang E, Sandhoff K. 1993. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J Biol Chem. 268(36):27299–27306.
  • Minervini F, Garbetta A, D'Antuono I, Cardinali A, Martino NA, Debellis L, Visconti A. 2014. Toxic mechanisms induced by fumonisin B1 mycotoxin on human intestinal cell line. Arch Environ Contam Toxicol. 67(1):115–123.
  • Missmer SA, Suarez L, Felkner M, Wang E, Merrill AH, Rothman KJ, Hendricks KA. 2006. Exposure to fumonisins and the occurrence of neural tube defects along the Texas–Mexico border. Environ Health Perspect. 114:237–241.
  • Mobio TA, Anane R, Baudrimont I, Carratú MR, Shier TW, Dano SD, Ueno Y, Creppy EE. 2000. Epigenetic properties of fumonisin B(1): cell cycle arrest and DNA base modification in C6 glioma cells. Toxicol Appl Pharmacol. 164(1):91–96.
  • Mobio TA, Tavan E, Baudrimont I, Anane R, Carratú M-R, Sanni A, Gbeassor MF, Shier TW, Narbonne J-F, Creppy EE. 2003. Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. Toxicology. 183(1–3):65–75.
  • Moore LD, Le T, Fan G. 2013. DNA methylation and its basic function. Neuropsychopharmacology. 38(1):23–38.
  • Nguyen T, Nioi P, Pickett CB. 2009. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 284(20):13291–13295.
  • O'Brien J, Hayder H, Zayed Y, Peng C. 2018. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne). 9:402.
  • Odhav B, Adam JK, Bhoola KD. 2008. Modulating effects of fumonisin B1 and ochratoxin A on leukocytes and messenger cytokines of the human immune system. Int Immunopharmacol. 8(6):799–809.
  • Okabe I, Hiraoka H, Miki K. 2015. Influence of harvest time on fumonisin contamination of forage maize for whole-crop silage. Mycoscience. 56(5):470–475.
  • Oswald IP, Desautels C, Laffitte J, Fournout S, Peres SY, Odin M, Le Bars P, Le Bars J, Fairbrother JM. 2003. Mycotoxin fumonisin B1 increases intestinal colonization by pathogenic Escherichia coli in pigs. Appl Environ Microbiol. 69(10):5870–5874.
  • Oswald IP, Marin DE, Bouhet S, Pinton P, Taranu I, Accensi F. 2005. Immunotoxicological risk of mycotoxins for domestic animals. Food Addit Contam. 22(4):354–360.
  • Pellanda H, Forges T, Bressenot A, Chango A, Bronowicki JP, Guéant JL, Namour F. 2012. Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses. Mol Nutr Food Res. 56(6):976–985.
  • Phokane S, Flett BC, Ncube E, Rheeder JP, Rose LJ. 2019. Agricultural practices and their potential role in mycotoxin contamination of maize and groundnut subsistence farming. S Afr J Sci. 115(9/10):1–6.
  • Piacentini KC, Rocha LO, Fontes LC, Carnielli L, Reis TA, Corrêa B. 2017. Mycotoxin analysis of industrial beers from Brazil: the influence of fumonisin B1 and deoxynivalenol in beer quality. Food Chem. 218:64–69.
  • Pizzolitto RP, Salvano MA, Dalcero AM. 2012. Analysis of fumonisin B1 removal by microorganisms in co-occurrence with aflatoxin B1 and the nature of the binding process. Int J Food Microbiol. 156(3):214–221.
  • Podhorecka M, Skladanowski A, Bozko P. 2010. H2AX phosphorylation: its role in DNA damage response and cancer therapy. J Nucleic Acids. 2010:1–9.
  • Qian G, Tang L, Lin S, Xue KS, Mitchell NJ, Su J, Gelderblom WC, Riley RT, Phillips TD, Wang J-S. 2016. Sequential dietary exposure to aflatoxin B1 and fumonisin B1 in F344 rats increases liver preneoplastic changes indicative of a synergistic interaction. Food Chem Toxicol. 95:188–195.
  • Qiu M, Liu X, Wang Y, Zhang C. 2001. Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer. Wei Sheng Yan Jiu. 30:365–367.
  • Ramljak D, Calvert RJ, Wiesenfeld PW, Diwan BA, Catipovic B, Marasas WFO, Victor TC, Anderson LM, Gelderblom WCA. 2000. A potential mechanism for fumonisin B1-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3β activity. Carcinogenesis. 21(8):1537–1546.
  • Rani V, Deep G, Singh RK, Palle K, Yadav UC. 2016. Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies. Life Sci. 148:183–193.
  • Reddy B, Raghavender C. 2008. Outbreaks of fusarial-toxicoses in India. Cereal Res Commun. 36(Suppl. 6):321–325.
  • Reik W, Dean W. 2001. DNA methylation and mammalian epigenetics. Electrophoresis. 22(14):2838–2843.
  • Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. 2010. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 49(11):1603–1616.
  • Rheeder JP, Marasas WFO, Vismer HF. 2002. Production of fumonisin analogs by Fusarium species. Appl Environ Microbiol. 68(5):2101–2105.
  • Rice JC, Allis CD. 2001. Histone methylation versus histone acetylation: new insights into epigenetic regulation. Curr Opin Cell Biol. 13(3):263–273.
  • Riley RT, Enongene E, Voss KA, Norred WP, Meredith FI, Sharma RP, Spitsbergen J, Williams DE, Carlson DB, Merrill AH Jr. 2001. Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ Health Perspect. 109(Suppl. 2):301–308.
  • Riley RT, Merrill AH Jr. 2019. Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease. J Lipid Res. 60:1183–1189.
  • Riley RT, Showker JL, Lee CM, Zipperer CE, Mitchell TR, Voss KA, Zitomer NC, Torres O, Matute J, Gregory SG. 2015. A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 32:934–949.
  • Riley RT, Torres O, Matute J, Gregory SG, Ashley-Koch AE, Showker JL, Mitchell T, Voss KA, Maddox JR, Gelineau-van Waes JB. 2015. Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. Mol Nutr Food Res. 59(11):2209–2224.
  • Robinson A, Johnson NM, Strey A, Taylor JF, Marroquin-Cardona A, Mitchell NJ, Afriyie-Gyawu E, Ankrah NA, Williams JH, Wang JS. 2012. Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B1 exposure in rats and humans. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 29:809–818.
  • Saksouk N, Simboeck E, Déjardin J. 2015. Constitutive heterochromatin formation and transcription in mammals. Epigenetics Chromatin. 8:3.
  • Sancak D, Ozden S. 2015. Global histone modifications in fumonisin B1 exposure in rat kidney epithelial cells. Toxicol In Vitro. 29(7):1809–1815.
  • Sawan C, Vaissière T, Murr R, Herceg Z. 2008. Epigenetic drivers and genetic passengers on the road to cancer. Mutat Res. 642(1–2):1–13.
  • Schieber M, Chandel Navdeep S. 2014. ROS function in redox signaling and oxidative stress. Curr Biol. 24(10):R453–R462.
  • Schmelz EM, Dombrink-Kurtzman MA, Roberts PC, Kozutsumi Y, Kawasaki T, Merrill AH. 1998. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol Appl Pharmacol. 148(2):252–260.
  • Schwarz DS, Blower MD. 2016. The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci. 73(1):79–94.
  • Seiferlein M, Humpf H-U, Voss KA, Sullards MC, Allegood JC, Wang E, Merrill AH. 2007. Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. Mol Nutr Food Res. 51(9):1120–1130.
  • Senft D, Ronai ZA. 2015. UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci. 40(3):141–148.
  • Sharma RP, Bhandari N, He Q, Riley RT, Voss KA. 2001. Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1. Toxicology. 159(1–2):69–79.
  • Sharma RP, Bhandari N, Riley RT, Voss KA, Meredith FI. 2000. Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor. Toxicology. 143(2):183–194.
  • Sharma RP, He Q, Johnson VJ. 2003. Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. J Interferon Cytokine Res. 23(1):13–23.
  • Sharma S, Kelly TK, Jones PA. 2010. Epigenetics in cancer. Carcinogenesis. 31(1):27–36.
  • Shephard GS, Burger H-M, Rheeder JP, Alberts JF, Gelderblom WCA. 2019. The effectiveness of regulatory maximum levels for fumonisin mycotoxins in commercial and subsistence maize crops in South Africa. Food Control. 97:77–80.
  • Shirima CP, Kimanya ME, Routledge MN, Srey C, Kinabo JL, Humpf H-U, Wild CP, Tu Y-K, Gong YY. 2015. A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania. Environ Health Perspect. 123(2):173–178.
  • Sies H, Berndt C, Jones DP. 2017. Oxidative stress. Annu Rev Biochem. 86:715–748.
  • Singh MP, Chul S. 2017. Endoplasmic reticulum stress-mediated autophagy activation attenuates fumonisin B1 induced hepatotoxicity in vitro and in vivo. Food Chem Toxicol. 110:371–382.
  • Soriano JM, González L, Catalá AI. 2005. Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. Prog Lipid Res. 44(6):345–356.
  • Stevens FJ, Argon Y. 1999. Protein folding in the ER. Semin Cell Dev Biol. 10(5):443–454.
  • Stockmann-Juvala H, Mikkola J, Naarala J, Loikkanen J, Elovaara E, Savolainen K. 2004a. Oxidative stress induced by fumonisin B1 in continuous human and rodent neural cell cultures. Free Radic Res. 38(9):933–942.
  • Stockmann-Juvala H, Mikkola J, Naarala J, Loikkanen J, Elovaara E, Savolainen K. 2004b. Fumonisin B1-induced toxicity and oxidative damage in U-118MG glioblastoma cells. Toxicology. 202(3):173–183.
  • Sun K, Deng W, Zhang S, Cai N, Jiao S, Song J, Wei L. 2013. Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells. Cell Biosci. 3(1):35–35.
  • Sun G, Wang S, Hu X, Su J, Huang T, Yu J, Tang L, Gao W, Wang J-S. 2007. Fumonisin B1 contamination of home-grown corn in high-risk areas for esophageal and liver cancer in China. Food Addit Contam. 24(2):181–185.
  • Sun G, Wang S, Hu X, Su J, Zhang Y, Xie Y, Zhang H, Tang L, Wang JS. 2011. Co-contamination of aflatoxin B1 and fumonisin B1 in food and human dietary exposure in three areas of China. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 28(4):461–470.
  • Surai P, Mezes M. 2005. Mycotoxins and immunity: theoretical consideration and practical applications. Praxis Vet. 53:71–88.
  • Sydenham EW, Thiel PG, Marasas WF, Shephard GS, Van Schalkwyk DJ, Koch KR. 1990. Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, Southern Africa. J Agric Food Chem. 38(10):1900–1903.
  • Taranu I, Marin DE, Bouhet S, Pascale F, Bailly J-D, Miller JD, Pinton P, Oswald IP. 2005. Mycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol Sci. 84(2):301–307.
  • Theumer MG, Cánepa MC, López AG, Mary VS, Dambolena JS, Rubinstein HR. 2010. Subchronic mycotoxicoses in Wistar rats: assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B(1), and oxidative stress biomarkers status. Toxicology. 268(1–2):104–110.
  • Tornyos G, Kovács M, Rusvai M, Horn P, Fodor J, Kovacs F. 2003. Effect of dietary fumonisin B1 on certain immune parameters of weaned pigs. Acta Vet Hung. 51(2):171–179.
  • Torres OA, Palencia E, de Pratdesaba LL, Grajeda R, Fuentes M, Speer MC, Merrill AH, O'Donnell K, Bacon CW, Glenn AE, et al. 2007. Estimated fumonisin exposure in Guatemala is greatest in consumers of lowland maize. J Nutr. 137(12):2723–2729.
  • Tryphonas H, Bondy G, Miller J, Lacroix F, Hodgen M, McGuire P, Fernie S, Miller D, Hayward S. 1997. Effects of fumonisin B1 on the immune system of Sprague-Dawley rats following a 14-day oral (gavage) exposure. Toxicol Sci. 39(1):53–59.
  • Valavanidis A, Vlachogianni T, Fiotakis C. 2009. 8-Hydroxy-2′-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 27(2):120–139.
  • Van Den Broeck A, Brambilla E, Moro-Sibilot D, Lantuejoul S, Brambilla C, Eymin B, Khochbin S, Gazzeri S. 2008. Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer. Clin Cancer Res. 14(22):7237–7245.
  • van der Westhuizen L, Shephard GS, Burger HM, Rheeder JP, Gelderblom WCA, Wild CP, Gong YY. 2011. Fumonisin B1 as a urinary biomarker of exposure in a maize intervention study among South African subsistence farmers. Cancer Epidemiol Biomarkers Prev. 20(3):483–489.
  • Varga J, Kocsubé S, Suri K, Szigeti G, Szekeres A, Varga M, Tóth B, Bartók T. 2010. Fumonisin contamination and fumonisin producing black Aspergilli in dried vine fruits of different origin. Int J Food Microbiol. 143(3):143–149.
  • Voss KA, Bacon CW, Meredith FI, Norred WP. 1996. Comparative subchronic toxicity studies of nixtamalized and water-extracted Fusarium moniliforme culture material. Food Chem Toxicol. 34(7):623–632.
  • Voss KA, Howard PC, Riley RT, Sharma RP, Bucci TJ, Lorentzen RJ. 2002. Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides). Cancer Detect Prev. 26(1):1–9.
  • Voss KA, Riley RT, Jackson LS, Jablonski JE, Bianchini A, Bullerman LB, Hanna MA, Ryu D. 2011. Extrusion cooking with glucose supplementation of fumonisin‐contaminated corn grits protects against nephrotoxicity and disrupted sphingolipid metabolism in rats. Mol Nutr Food Res. 55(S2):S312–S320.
  • Voss KA, Riley RT, Moore ND, Burns TD. 2013. Alkaline cooking (nixtamalisation) and the reduction in the in vivo toxicity of fumonisin-contaminated corn in a rat feeding bioassay. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30(8):1415–1421.
  • Voss K, Ryu D, Jackson L, Riley R, Waes J. 2017. Reduction of fumonisin toxicity by extrusion and nixtamalization (alkaline cooking). J Agric Food Chem. 65(33):7088–7096.
  • Wan L-YM, Woo C-SJ, Turner PC, Wan JM-F, El-Nezami H. 2013. Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells. Toxicol Lett. 220(3):238–246.
  • Wang E, Norred WP, Bacon CW, Riley RT, Merrill AH Jr. 1991. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem. 266(22):14486–14490.
  • Wang H, Wei H, Luo X. 2000. The fumonisin B1 content in corn from North China, a high-risk area of esophageal cancer. J Environ Pathol Toxicol Oncol. 19:139–141.
  • Waskiewicz A, Irzykowska L, Bocianowski J, Karolewski Z, Kostecki M, Golinski P. 2010. Occurrence of Fusarium fungi and mycotoxins in marketable Asparagus spears. Pol J Environ Stud. 19:219–225.
  • Wild CP, Gong YY. 2010. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis. 31(1):71–82.
  • Wilson TM, Nelson PE, Knepp C. 1985. Hepatic neoplastic nodules, adenofibrosis, and cholangiocarcinomas in male Fisher 344 rats fed corn naturally contaminated with Fusarium moniliforme. Carcinogenesis. 6(8):1155–1160.
  • Yang W-C, Hwang Y-S, Chen Y-Y, Liu C-L, Shen C-N, Hong W-H, Lo S-M, Shen C-R. 2017. Interleukin-4 supports the suppressive immune responses elicited by regulatory T cells. Front Immunol. 8:1508.
  • Yao ZG, Zhang XH, Hua F, Wang J, Xing X, Wang JL, Yan X, Xing LX. 2011. Effects of fumonisin B1 on HLA class I antigen presentation and processing pathway in GES-1 cells in vitro. Hum Exp Toxicol. 30(5):379–390.
  • Yin S, Guo X, Li J, Fan L, Hu H. 2016. Fumonisin B1 induces autophagic cell death via activation of ERN1-MAPK8/9/10 pathway in monkey kidney MARC-145 cells. Arch Toxicol. 90(4):985–996.
  • Yoo HS, Norred WP, Wang E, Merrill AH Jr, Riley RT. 1992. Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicol Appl Pharmacol. 114(1):9–15.
  • Yorimitsu T, Nair U, Yang Z, Klionsky DJ. 2006. Endoplasmic reticulum stress triggers autophagy. J Biol Chem. 281(40):30299–30304.
  • Yoshizawa T, Yamashita A, Luo Y. 1994. Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. Appl Environ Microbiol. 60(5):1626–1629.
  • Yu S, Jia B, Yang Y, Liu N, Wu A. 2020. Involvement of PERK-CHOP pathway in fumonisin B1-induced cytotoxicity in human gastric epithelial cells. Food Chem Toxicol. 136:111080.
  • Zadeh MHB, Shahdadi H. 2015. Nanocellulose coated with various free fatty acids can adsorb fumonisin B1, and decrease its toxicity. Colloids Surf B Biointerfaces. 134:26–30.
  • Zhang W, Zhang S, Zhang M, Yang L, Cheng B, Li J, Shan A. 2018. Individual and combined effects of Fusarium toxins on apoptosis in PK15 cells and the protective role of N-acetylcysteine. Food Chem Toxicol. 111:27–43.
  • Zitomer NC, Mitchell T, Voss KA, Bondy GS, Pruett ST, Garnier-Amblard EC, Liebeskind LS, Park H, Wang E, Sullards MC, et al. 2009. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. J Biol Chem. 284(8):4786–4795.

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