Regulatory roles of extracellular vesicles in adverse pregnancy outcomes exposed with environmental toxicants

References

• Aimuzi R, Huang S, Luo K, Ma S, Huo X, Li G, Tian Y, Zhang J, Yu Y. 2022. Levels and health risks of urinary phthalate metabolites and the association between phthalate exposure and unexplained recurrent spontaneous abortion: a large case-control study from China. Environ Res. 212(Pt C):113393.
   PubMedGoogle Scholar
• Amiri N, Mohammadi P, Allahgholi A, Salek F, Amini E. 2023. The potential of sertoli cells (SCs) derived exosomes and its therapeutic efficacy in male reproductive disorders. Life Sci. 312:121251.
   PubMedGoogle Scholar
• Araújo JR, Keating E, Martel F. 2015. Impact of gestational diabetes mellitus in the maternal-to-fetal transport of nutrients. Curr Diab Rep. 15(2):569.
   PubMed Web of Science ®Google Scholar
• Archibong AE, Inyang F, Ramesh A, Greenwood M, Nayyar T, Kopsombut P, Hood DB, Nyanda AM. 2002. Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene. Reprod Toxicol. 16(6):801–808.
   PubMed Web of Science ®Google Scholar
• Bai J, Deng J, Han Z, Cui Y, He R, Gu Y, Zhang Q. 2021. CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis. Toxicol Lett. 347:58–66.
   PubMed Web of Science ®Google Scholar
• Bao C, Lyu D, Huang S. 2016. Circular RNA expands its territory. Mol Cell Oncol. 3(2):e1084443.
   PubMedGoogle Scholar
• Barile L, Vassalli G. 2017. Exosomes: therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 174:63–78.
   PubMed Web of Science ®Google Scholar
• Bobrie A, Colombo M, Raposo G, Théry C. 2011. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 12(12):1659–1668.
   PubMed Web of Science ®Google Scholar
• Bonifácio VDB. 2020. Ovarian cancer biomarkers: moving forward in early detection. Adv Exp Med Biol. 1219:355–363.
   PubMed Web of Science ®Google Scholar
• Bukowska B, Mokra K, Michałowicz J. 2022. Benzo[a]pyrene-environmental occurrence, human exposure, and mechanisms of toxicity. Int J Mol Sci. 23(11):6348.
   PubMed Web of Science ®Google Scholar
• Bunggulawa EJ, Wang W, Yin T, Wang N, Durkan C, Wang Y, Wang G. 2018. Recent advancements in the use of exosomes as drug delivery systems. J Nanobiotechnol. 16(1):81.
   PubMedGoogle Scholar
• Cao M, Wen J, Bu C, Li C, Lin Y, Zhang H, Gu Y, Shi Z, Zhang Y, Long W, et al. 2021. Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients. BMC Pregnancy Childbirth. 21(1):303.
   PubMedGoogle Scholar
• Cao M, Zhang L, Lin Y, Li Z, Xu J, Shi Z, Chen Z, Ma J, Wen J. 2020a. Circular RNA expression profiles in umbilical cord blood exosomes from normal and gestational diabetes mellitus patients. Biosci Rep. 40(11). :BSR20201946
   Google Scholar
• Cao M, Zhang L, Lin Y, Li Z, Xu J, Shi Z, Chen Z, Ma J, Wen J. 2020b. Differential mRNA and long noncoding RNA expression profiles in umbilical cord blood exosomes from gestational diabetes mellitus patients. DNA Cell Biol. 39(11):2005–2016.
   PubMedGoogle Scholar
• Carthew RW, Sontheimer EJ. 2009. Origins and mechanisms of miRNAs and siRNAs. Cell. 136(4):642–655.
   PubMed Web of Science ®Google Scholar
• Chaput N, Théry C. 2011. Exosomes: immune properties and potential clinical implementations. Semin Immunopathol. 33(5):419–440.
   PubMed Web of Science ®Google Scholar
• Chen C, Luo F, Liu X, Lu L, Xu H, Yang Q, Xue J, Shi L, Li J, Zhang A, et al. 2017. NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis. Cancer Lett. 388:21–33.
   PubMed Web of Science ®Google Scholar
• Chen Y, Ding H, Wei M, Zha W, Guan S, Liu N, Li Y, Tan Y, Wang Y, Wu F. 2020. MSC-secreted exosomal H19 promotes trophoblast cell invasion and migration by downregulating let-7b and upregulating FOXO1. Mol Ther Nucleic Acids. 19:1237–1249.
   PubMedGoogle Scholar
• Chiarello DI, Salsoso R, Toledo F, Mate A, Vázquez CM, Sobrevia L. 2018. Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia. Mol Aspects Med. 60:69–80.
   PubMed Web of Science ®Google Scholar
• Chu Y, Chen W, Peng W, Liu Y, Xu L, Zuo J, Zhou J, Zhang Y, Zhang N, Li J, et al. 2020. Amnion-derived mesenchymal stem cell exosomes-mediated autophagy promotes the survival of trophoblasts under hypoxia through mTOR pathway by the downregulation of EZH2. Front Cell Dev Biol. 8:545852.
   PubMedGoogle Scholar
• Colombo M, Raposo G, Théry C. 2014. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 30(1):255–289.
   PubMed Web of Science ®Google Scholar
• Csorba R, Yilmaz A, Tsikouras P, Wieg C, Teichmann A, von Tempelhoff G-F. 2013. Rheological parameters in the umbilical cord blood in moderate and severe forms of preeclampsia. Clin Hemorheol Microcirc. 55(4):391–401.
   PubMed Web of Science ®Google Scholar
• Czech B, Munafò M, Ciabrelli F, Eastwood EL, Fabry MH, Kneuss E, Hannon GJ. 2018. piRNA-Guided genome defense: from biogenesis to silencing. Annu Rev Genet. 52(1):131–157.
   PubMed Web of Science ®Google Scholar
• da Silveira JC, de Andrade GM, Nogueira MFG, Meirelles FV, Perecin F. 2015. Involvement of miRNAs and cell-secreted vesicles in mammalian ovarian antral follicle development. Reprod Sci. 22(12):1474–1483.
   PubMedGoogle Scholar
• da Silveira JC, Winger QA, Bouma GJ, Carnevale EM. 2015. Effects of age on follicular fluid exosomal microRNAs and granulosa cell transforming growth factor-β signalling during follicle development in the mare. Reprod Fertil Dev. 27(6):897–905.
   PubMed Web of Science ®Google Scholar
• Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, Tao Y, He Z, Chen C, Jiang Y. 2020. Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther. 5(1):145.
   PubMed Web of Science ®Google Scholar
• Dai M, Huang W, Huang X, Ma C, Wang R, Tian1 P, Chen W, Zhang Y, Mi C, Zhang H. 2023. BPDE, the migration and invasion of human trophoblast cells and occurrence of miscarriage in humans roles of a novel lncRNA-HZ09. Environ Health Perspect. 131(1):17009.
   PubMedGoogle Scholar
• Dai X, Chen C, Xue J, Xiao T, Mostofa G, Wang D, Chen X, Xu H, Sun Q, Li J, et al. 2019. Exosomal MALAT1 derived from hepatic cells is involved in the activation of hepatic stellate cells via miRNA-26b in fibrosis induced by arsenite. Toxicol Lett. 316:73–84.
   PubMed Web of Science ®Google Scholar
• Dai X, Chen C, Yang Q, Xue J, Chen X, Sun B, Luo F, Liu X, Xiao T, Xu H, et al. 2018. Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation. Cell Death Dis. 9(5):454.
   PubMed Web of Science ®Google Scholar
• Deatherage BL, Cookson BT. 2012. Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life. Infect Immun. 80(6):1948–1957.
   PubMed Web of Science ®Google Scholar
• Dejmek J, Solansky I, Benes I, Lenicek J, Sram RJ. 2000. The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome. Environ Health Perspect. 108(12):1159–1164.
   PubMed Web of Science ®Google Scholar
• Delorme-Axford E, Donker RB, Mouillet J-F, Chu T, Bayer A, Ouyang Y, Wang T, Stolz DB, Sarkar SN, Morelli AE, et al. 2013. Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci USA. 110(29):12048–12053.
   PubMed Web of Science ®Google Scholar
• Denzer K, van Eijk M, Kleijmeer MJ, Jakobson E, de Groot C, Geuze HJ. 2000. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J Immunol. 165(3):1259–1265.
   PubMed Web of Science ®Google Scholar
• Dutta S, Lai A, Scholz-Romero K, Shiddiky MJA, Yamauchi Y, Mishra JS, Rice GE, Hyett J, Kumar S, Salomon C. 2020. Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats. Clin Sci. 134(6):593–607.
   Google Scholar
• Fazzi C, Saunders DH, Linton K, Norman JE, Reynolds RM. 2017. Sedentary behaviours during pregnancy: a systematic review. Int J Behav Nutr Phys Act. 14(1):32.
   PubMedGoogle Scholar
• Ferrari L, Iodice S, Cantone L, Solazzo G, Dioni L, Hoxha M, Vicenzi M, Mozzoni P, Bergamaschi E, Persico N, et al. 2022. Extracellular vesicles and their miRNA contents counterbalance the pro-inflammatory effect of air pollution during physiological pregnancy: a focus on Syncytin-1 positive vesicles. Environ Int. 169:107502.
   PubMedGoogle Scholar
• Foley HB, Howe CG, Eckel SP, Chavez T, Gevorkian L, Reyes EG, Kapanke B, Martinez D, Xue S, Suglia SF, et al. 2021. Extracellular vesicle-enriched miRNA profiles across pregnancy in the MADRES cohort. PLOS One. 16(5):e0251259.
   PubMed Web of Science ®Google Scholar
• Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota T, Hara H, Kuwano K, Ochiya T. 2015. Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis. J Extracell Vesicles. 4(1):28388.
   PubMed Web of Science ®Google Scholar
• Gao M, Dong Z, Sun J, Liu W, Xu M, Li C, Zhu P, Yang X, Shang X, Wu Y, et al. 2020. Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity. Environ Pollut. 258:113717.
   PubMed Web of Science ®Google Scholar
• Gebara N, Scheel J, Skovronova R, Grange C, Marozio L, Gupta S, Giorgione V, Caicci F, Benedetto C, Khalil A, et al. 2022. Single extracellular vesicle analysis in human amniotic fluid shows evidence of phenotype alterations in preeclampsia. J Extracell Vesicle. 11(5):e12217.
   PubMedGoogle Scholar
• Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. 2016. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 30(5):2058–2063.
   PubMed Web of Science ®Google Scholar
• Gómez-Roig MD, Pascal R, Cahuana MJ, García-Algar O, Sebastiani G, Andreu-Fernández V, Martínez L, Rodríguez G, Iglesia I, Ortiz-Arrabal O, et al. 2021. Environmental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review. Fetal Diagn Ther. 48(4):245–257.
   PubMedGoogle Scholar
• Greening DW, Nguyen HPT, Elgass K, Simpson RJ, Salamonsen LA. 2016. Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions. Biol Reprod. 94(2):38.
   PubMed Web of Science ®Google Scholar
• Griebel CP, Halvorsen J, Golemon TB, Day AA. 2005. Management of spontaneous abortion. Am Fam Physician. 72(7):1243–1250.
   PubMed Web of Science ®Google Scholar
• György B, Szabó TG, Pásztói M, Pál Z, Misják P, Aradi B, László V, Pállinger E, Pap E, Kittel A, et al. 2011. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 68(16):2667–2688.
   PubMed Web of Science ®Google Scholar
• Gysler SM, Mulla MJ, Guerra M, Brosens JJ, Salmon JE, Chamley LW, Abrahams VM. 2016. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Mol Hum Reprod. 22(7):465–474.
   PubMed Web of Science ®Google Scholar
• Han Y, Jia L, Zheng Y, Li W. 2018. Salivary exosomes: emerging roles in systemic disease. Int J Biol Sci. 14(6):633–643.
   PubMed Web of Science ®Google Scholar
• Hanly DJ, Esteller M, Berdasco M. 2018. Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? Philos Trans R Soc Lond B Biol Sci. 373(1748):20170074.
   PubMed Web of Science ®Google Scholar
• Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy AG. 2018. Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson’s disease: relevance to α-synuclein misfolding in metal neurotoxicity. Neurotoxicology. 64:267–277.
   PubMed Web of Science ®Google Scholar
• Harris EA, Stephens KK, Winuthayanon W. 2020. Extracellular vesicles and the oviduct function. Int J Mol Sci. 21(21):8280.
   PubMedGoogle Scholar
• Herrera-Van Oostdam AS, Toro-Ortíz JC, López JA, Noyola DE, García-López DA, Durán-Figueroa NV, Martínez-Martínez E, Portales-Pérez DP, Salgado-Bustamante M, López-Hernández Y. 2020. Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. Int J Mol Med. 46(2):546–560.
   PubMedGoogle Scholar
• Hoshino A, Costa-Silva B, Shen T-L, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, et al. 2015. Tumour exosome integrins determine organotropic metastasis. Nature. 527(7578):329–335.
   PubMed Web of Science ®Google Scholar
• Howe CG, Foley HB, Farzan SF, Chavez TA, Johnson M, Meeker JD, Bastain TM, Marsit CJ, Breton CV. 2022. Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort. Epigenetics. 17(10):1128–1142.
   PubMedGoogle Scholar
• Howe CG, Foley HB, Kennedy EM, Eckel SP, Chavez TA, Faham D, Grubbs BH, Al-Marayati L, Lerner D, Suglia S, et al. 2022. Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study. Epigenetics. 17(3):269–285.
   PubMed Web of Science ®Google Scholar
• Hromadnikova I, Dvorakova L, Kotlabova K, Krofta L. 2019. The prediction of gestational hypertension, preeclampsia and fetal growth restriction via the first trimester screening of plasma exosomal C19MC microRNAs. Int J Mol Sci. 20(12):2972.
   PubMed Web of Science ®Google Scholar
• Huang Q, Gong M, Tan T, Lin Y, Bao Y, Fan C. 2021. Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-18b-3p inhibits the occurrence of preeclampsia by targeting LEP. Nanoscale Res Lett. 16(1):27.
   PubMedGoogle Scholar
• Huang W, Dai M, Qiu T, Liang T, Xie J, Mi C, Zhao J, Chen W, Tian P, Zhang S, et al. 2021. Novel lncRNA-HZ04 promotes BPDE-induced human trophoblast cell apoptosis and miscarriage by upregulating IP(3) R(1)/CaMKII/SGCB pathway by competitively binding with miR-hz04. FASEB J. 35(9):e21789.
   PubMed Web of Science ®Google Scholar
• Huang X, Ma C, Huang W, Dai M, Yang J, Xu X, Deng Y, Yang Y, Zhang H. 2022. Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop. Ecotoxicol Environ Saf. 237:113564.
   PubMedGoogle Scholar
• Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. 2020. Preeclampsia-pathophysiology and clinical presentations: JACC state-of-the-art review. J Am Coll Cardiol. 76(14):1690–1702.
   PubMed Web of Science ®Google Scholar
• Jedrychowski WA, Majewska R, Spengler JD, Camann D, Roen EL, Perera FP. 2017. Prenatal exposure to fine particles and polycyclic aromatic hydrocarbons and birth outcomes: a two-pollutant approach. Int Arch Occup Environ Health. 90(3):255–264.
   PubMed Web of Science ®Google Scholar
• Ji L, Zhang L, Li Y, Guo L, Cao N, Bai Z, Song Y, Xu Z, Zhang J, Liu C, et al. 2017. MiR-136 contributes to pre-eclampsia through its effects on apoptosis and angiogenesis of mesenchymal stem cells. Placenta. 50:102–109.
   PubMed Web of Science ®Google Scholar
• Jia L, Zhou X, Huang X, Xu X, Jia Y, Wu Y, Yao J, Wu Y, Wang K. 2018. Maternal and umbilical cord serum-derived exosomes enhance endothelial cell proliferation and migration. FASEB J. 32(8):4534–4543.
   PubMed Web of Science ®Google Scholar
• Jia Y, Chen Y, Wang Q, Jayasinghe U, Luo X, Wei Q, Wang J, Xiong H, Chen C, Xu B, et al. 2017. Exosome: emerging biomarker in breast cancer. Oncotarget. 8(25):41717–41733.
   PubMed Web of Science ®Google Scholar
• Jiang R, Huang H, Lian Z, Hu Z, Lloyd RS, Fang D, Li Y, Xian H, Yuan J, Sha Y, et al. 2020. Exosomal miR-221 derived from hydroquinone-transformed malignant human bronchial epithelial cells is involved in cell viability of recipient cells. J Appl Toxicol. 40(2):224–233.
   PubMedGoogle Scholar
• Johns EC, Denison FC, Norman JE, Reynolds RM. 2018. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 29(11):743–754.
   PubMed Web of Science ®Google Scholar
• Kahn LG, Trasande L. 2018. Environmental toxicant exposure and hypertensive disorders of pregnancy: recent findings. Curr Hypertens Rep. 20(10):87.
   PubMed Web of Science ®Google Scholar
• Kambe S, Yoshitake H, Yuge K, Ishida Y, Ali MM, Takizawa T, Kuwata T, Ohkuchi A, Matsubara S, Suzuki M, et al. 2014. Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells. Biol Reprod. 91(5):129.
   PubMedGoogle Scholar
• Keerthikumar S, Chisanga D, Ariyaratne D, Saffar A, Anand H, Zhao S, Samuel K, Pathan M, Jois M, Chilamkurti M, et al. 2016. ExoCarta: a web-based compendium of exosomal cargo. J Mol Biol. 428(4):688–692.
   PubMed Web of Science ®Google Scholar
• Kopp F, Mendell JT. 2018. Functional classification and experimental dissection of long noncoding RNAs. Cell. 172(3):393–407.
   PubMed Web of Science ®Google Scholar
• Kupsco A, Lee JJ, Prada D, Valvi D, Hu L, Petersen MS, Coull BA, Weihe P, Grandjean P, Baccarelli AA. 2022. Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands. Environ Int. 158:106986.
   PubMedGoogle Scholar
• Kwon J-Y, Maeng Y-S, Kwon Y-G, Kim Y-H, Kang M-H, Park Y-W. 2007. Decreased endothelial progenitor cells in umbilical cord blood in severe preeclampsia. Gynecol Obstet Invest. 64(2):103–108.
   PubMed Web of Science ®Google Scholar
• Li R, Jiang J, Shi H, Qian H, Zhang X, Xu W. 2020. CircRNA: a rising star in gastric cancer. Cell Mol Life Sci. 77(9):1661–1680.
   PubMed Web of Science ®Google Scholar
• Li X, Song Y, Liu F, Liu D, Miao H, Ren J, Xu J, Ding L, Hu Y, Wang Z, et al. 2017. Long non-coding RNA MALAT1 promotes proliferation, angiogenesis, and immunosuppressive properties of mesenchymal stem cells by inducing VEGF and IDO. J Cell Biochem. 118(9):2780–2791.
   PubMed Web of Science ®Google Scholar
• Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. 2015. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 25(8):981–984.
   PubMed Web of Science ®Google Scholar
• Lim J-H, Song M-K, Cho Y, Kim W, Han SO, Ryu J-C. 2017. Comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure. Toxicol In Vitro. 41:92–101.
   PubMed Web of Science ®Google Scholar
• Liu Y, Sharma S, Watabe K. 2015. Roles of lncRNA in breast cancer. Front Biosci. 7(1):94–108.
   Google Scholar
• Ma R, Liang Z, Shi X, Xu L, Li X, Wu J, Zhao L, Liu G. 2021. Exosomal miR-486-5p derived from human placental microvascular endothelial cells regulates proliferation and invasion of trophoblasts via targeting IGF1. Hum Cell. 34(5):1310–1323.
   PubMedGoogle Scholar
• Malik A, Jee B, Gupta SK. 2019. Preeclampsia: disease biology and burden, its management strategies with reference to India. Pregnancy Hypertens. 15:23–31.
   PubMed Web of Science ®Google Scholar
• Mallegol J, Van Niel G, Lebreton C, Lepelletier Y, Candalh C, Dugave C, Heath JK, Raposo G, Cerf-Bensussan N, Heyman M. 2007. T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology. 132(5):1866–1876.
   PubMed Web of Science ®Google Scholar
• Mashouri L, Yousefi H, Aref AR, Ahadi AM, Molaei F, Alahari SK. 2019. Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance. Mol Cancer. 18(1):75.
   PubMed Web of Science ®Google Scholar
• Mathieu M, Martin-Jaular L, Lavieu G, Théry C. 2019. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 21(1):9–17.
   PubMed Web of Science ®Google Scholar
• Meakin C, Barrett ES, Aleksunes LM. 2022. Extravillous trophoblast migration and invasion: impact of environmental chemicals and pharmaceuticals. Reprod Toxicol. 107:60–68.
   PubMedGoogle Scholar
• Menon R, Debnath C, Lai A, Guanzon D, Bhatnagar S, Kshetrapal PK, Sheller-Miller S, Salomon C. 2019. Circulating exosomal miRNA profile during term and preterm birth pregnancies: a longitudinal study. Endocrinology. 160(2):249–275.
   PubMed Web of Science ®Google Scholar
• Merchant ML, Rood IM, Deegens JKJ, Klein JB. 2017. Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery. Nat Rev Nephrol. 13(12):731–749.
   PubMed Web of Science ®Google Scholar
• Mobarak H, Rahbarghazi R, Lolicato F, Heidarpour M, Pashazadeh F, Nouri M, Mahdipour M. 2019. Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol. Syst Rev. 8(1):293.
   PubMedGoogle Scholar
• Mori MA, Ludwig RG, Garcia-Martin R, Brandão BB, Kahn CR. 2019. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 30(4):656–673.
   PubMed Web of Science ®Google Scholar
• Motawi TMK, Sabry D, Maurice NW, Rizk SM. 2018. Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation. Arch Biochem Biophys. 659:13–21.
   PubMed Web of Science ®Google Scholar
• Nair S, Jayabalan N, Guanzon D, Palma C, Scholz-Romero K, Elfeky O, Zuñiga F, Ormazabal V, Diaz E, Rice GE, et al. 2018. Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Clin Sci. 132(22):2451–2467.
   Google Scholar
• Nedaeinia R, Manian M, Jazayeri MH, Ranjbar M, Salehi R, Sharifi M, Mohaghegh F, Goli M, Jahednia SH, Avan A, et al. 2017. Circulating exosomes and exosomal microRNAs as biomarkers in gastrointestinal cancer. Cancer Gene Ther. 24(2):48–56.
   PubMed Web of Science ®Google Scholar
• Okala SG, Darboe MK, Sosseh F, Sonko B, Faye-Joof T, Prentice AM, Moore SE. 2019. Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: a randomised trial in The Gambia. PLOS Med. 16(8):e1002854.
   PubMed Web of Science ®Google Scholar
• Ospina-Prieto S, Chaiwangyen W, Herrmann J, Groten T, Schleussner E, Markert UR, Morales-Prieto DM. 2016. MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication. Transl Res. 172:61–72.
   PubMed Web of Science ®Google Scholar
• Pillay P, Moodley K, Moodley J, Mackraj I. 2017. Placenta-derived exosomes: potential biomarkers of preeclampsia. Int J Nanomedicine. 12:8009–8023.
   PubMed Web of Science ®Google Scholar
• Rai R, Regan L. 2006. Recurrent miscarriage. Lancet. 368(9535):601–611.
   PubMed Web of Science ®Google Scholar
• Raposo G, Stoorvogel W. 2013. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 200(4):373–383.
   PubMed Web of Science ®Google Scholar
• Rice GE, Scholz-Romero K, Sweeney E, Peiris H, Kobayashi M, Duncombe G, Mitchell MD, Salomon C. 2015. The effect of glucose on the release and bioactivity of exosomes from first trimester trophoblast cells. J Clin Endocrinol Metab. 100(10):E1280–E1288.
   PubMed Web of Science ®Google Scholar
• Rodosthenous RS, Burris HH, Sanders AP, Just AC, Dereix AE, Svensson K, Solano M, Téllez-Rojo MM, Wright RO, Baccarelli AA. 2017. Second trimester extracellular microRNAs in maternal blood and fetal growth: an exploratory study. Epigenetics. 12(9):804–810.
   PubMed Web of Science ®Google Scholar
• Rodosthenous RS, Coull BA, Lu Q, Vokonas PS, Schwartz JD, Baccarelli AA. 2016. Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals. Part Fibre Toxicol. 13:13.
   PubMedGoogle Scholar
• Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. 2019. Exosomes as mediators of chemical-induced toxicity. Curr Environ Health Rep. 6(3):73–79.
   PubMedGoogle Scholar
• Rolfo A, Nuzzo AM, De Amicis R, Moretti L, Bertoli S, Leone A. 2020. Fetal-maternal exposure to endocrine disruptors: correlation with diet intake and pregnancy outcomes. Nutrients. 12(6):1744.
   PubMed Web of Science ®Google Scholar
• Rong W, Shukun W., Xiaoqing W., Wenxin H., Mengyuan D., Chenyang M., Zhang H. 2022. Regulatory roles of non-coding RNAs and m6A modification in trophoblast functions and the occurrence of its related adverse pregnancy outcomes. Crit Rev Toxicol. 52(8):681–713.
   PubMedGoogle Scholar
• Rupaimoole R, Slack FJ. 2017. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16(3):203–222.
   PubMed Web of Science ®Google Scholar
• Salomon C, Scholz-Romero K, Sarker S, Sweeney E, Kobayashi M, Correa P, Longo S, Duncombe G, Mitchell MD, Rice GE, et al. 2016. Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation. Diabetes. 65(3):598–609.
   PubMed Web of Science ®Google Scholar
• Shah R, Patel T, Freedman JE. 2018. Circulating extracellular vesicles in human disease. N Engl J Med. 379(10):958–966.
   PubMed Web of Science ®Google Scholar
• Shi XT, Zhu HL, Xiong YW, Liu WB, Zhou GX, Cao XL, Yi SJ, Dai LM, Zhang C, Gao L, et al. 2020. Cadmium down-regulates 11β-HSD2 expression and elevates active glucocorticoid level via PERK/p-eIF2α pathway in placental trophoblasts. Chemosphere. 254:126785.
   PubMedGoogle Scholar
• Song M, Wang Y, Shang Z-F, Liu X-D, Xie D-F, Wang Q, Guan H, Zhou P-K. 2016. Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells. Sci Rep. 6(1):30165.
   PubMed Web of Science ®Google Scholar
• Song Y-H, Shao L, Zhang Y, Zhou J, Liu B, Pan X, Geng Y-J, Yu X-Y, Li Y. 2017. Exosomes derived from embryonic stem cells as potential treatment for cardiovascular diseases. Adv Exp Med Biol. 998:187–206.
   PubMedGoogle Scholar
• Šrám RJ, Binková B, Rössner P, Rubeš J, Topinka J, Dejmek J. 1999. Adverse reproductive outcomes from exposure to environmental mutagens. Mutat Res. 428(1–2):203–215.
   PubMed Web of Science ®Google Scholar
• Street ME, Bernasconi S. 2020. Endocrine-disrupting chemicals in human fetal growth. Int J Mol Sci. 21(4):1430.
   PubMed Web of Science ®Google Scholar
• Sun J, Deng G, Ruan X, Chen S, Liao H, Liu X, Li J, Zhao G, Gao J. 2020. Exosomal microRNAs in serum as potential biomarkers for ectopic pregnancy. Biomed Res Int. 2020:3521859.
   PubMedGoogle Scholar
• Sun Z, Shi K, Yang S, Liu J, Zhou Q, Wang G, Song J, Li Z, Zhang Z, Yuan W. 2018. Effect of exosomal miRNA on cancer biology and clinical applications. Mol Cancer. 17(1):147.
   PubMed Web of Science ®Google Scholar
• Sung S, Kim J, Jung Y. 2018. Liver-derived exosomes and their implications in liver pathobiology. Int J Mol Sci. 19(12):3715.
   PubMedGoogle Scholar
• Suwannakul B, Sapbamrer R, Wiwattanadittakul N, Hongsibsong S. 2021. Prenatal organophosphate exposure can cause adverse birth outcomes to humans. Environ Sci Pollut Res. 28(33):45064–45074.
   PubMedGoogle Scholar
• Tan Q, Shi S, Liang J, Cao D, Wang S, Wang Z. 2021. Endometrial cell-derived small extracellular vesicle miR-100-5p promotes functions of trophoblast during embryo implantation. Mol Ther Nucleic Acids. 23:217–231.
   PubMedGoogle Scholar
• Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al. 2018. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 7(1):1535750.
   PubMed Web of Science ®Google Scholar
• Thietart S, Rautou PE. 2020. Extracellular vesicles as biomarkers in liver diseases: a clinician’s point of view. J Hepatol. 73(6):1507–1525.
   PubMed Web of Science ®Google Scholar
• Tkach M, Théry C. 2016. Communication by extracellular vesicles: where we are and where we need to go. Cell. 164(6):1226–1232.
   PubMed Web of Science ®Google Scholar
• Varshavsky J, Smith A, Wang A, Hom E, Izano M, Huang H, Padula A, Woodruff TJ. 2020. Heightened susceptibility: a review of how pregnancy and chemical exposures influence maternal health. Reprod Toxicol. 92:14–56.
   PubMed Web of Science ®Google Scholar
• Wang D, Na Q, Song GY, Wang L. 2020. Human umbilical cord mesenchymal stem cell-derived exosome-mediated transfer of microRNA-133b boosts trophoblast cell proliferation, migration and invasion in preeclampsia by restricting SGK1. Cell Cycle. 19(15):1869–1883.
   PubMed Web of Science ®Google Scholar
• Wang S, Luan J, Lv X. 2019. Inhibition of endoplasmic reticulum stress attenuated ethanol-induced exosomal miR-122 and acute liver injury in mice. Alcohol Alcohol. 54(5):465–471.
   PubMedGoogle Scholar
• Wang Y, Zhong Y, Sun K, Fan Y, Liao J, Wang G. 2021. Identification of exosome miRNAs in bronchial epithelial cells after PM2.5 chronic exposure. Ecotoxicol Environ Saf. 215:112127.
   PubMedGoogle Scholar
• Wang Z, Wang P, Wang Z, Qin Z, Xiu X, Xu D, Zhang X, Wang Y. 2019. MiRNA-548c-5p downregulates inflammatory response in preeclampsia via targeting PTPRO. J Cell Physiol. 234(7):11149–11155.
   PubMed Web of Science ®Google Scholar
• Wilhelm M, Ghosh JK, Su J, Cockburn M, Jerrett M, Ritz B. 2011. Traffic-related air toxics and preterm birth: a population-based case-control study in Los Angeles County, California. Environ Health. 10(1):89.
   PubMedGoogle Scholar
• Witwer KW, Théry C. 2019. Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature. J Extracell Vesicles. 8(1):1648167.
   PubMed Web of Science ®Google Scholar
• Wu J, Hou H, Ritz B, Chen Y. 2010. Exposure to polycyclic aromatic hydrocarbons and missed abortion in early pregnancy in a Chinese population. Sci Total Environ. 408(11):2312–2318.
   PubMed Web of Science ®Google Scholar
• Wu R, Gao W, Yao K, Ge J. 2019. Roles of exosomes derived from immune cells in cardiovascular diseases. Front Immunol. 10:648.
   PubMed Web of Science ®Google Scholar
• Xian HY, Chen Y, Zhang JY, Tang ML, Lian ZW, Jiang R, Hu ZQ, Li, YF, Hu, Dl. 2021. Exosomes derived from hydroquinone-transformed human bronchial epithelial cells inhibited recipient cell apoptosis by transferring miR-221. Biomed Environ Sci. 34(7):520–527.
   PubMedGoogle Scholar
• Xiang Y-J, Hou Y-Y, Yan H-L, Liu H, Ge Y-X, Chen N, Xiang J-F, Hao C-F. 2020. Mesenchymal stem cells-derived exosomes improve pregnancy outcome through inducing maternal tolerance to the allogeneic fetus in abortion-prone mating mouse. Kaohsiung J Med Sci. 36(5):363–370.
   PubMedGoogle Scholar
• Xie J, Liang T, Zhao J, Xu Z, Tian P, Wang R, Mi C, Huang W, Chen W, Zhang H. 2022. Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage. Cell Biol Toxicol. 38(2):291–310.
   PubMed Web of Science ®Google Scholar
• Xie Y, Chen Y, Zhang L, Ge W, Tang P. 2017. The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling. J Cell Mol Med. 21(5):1033–1041.
   PubMed Web of Science ®Google Scholar
• Xie Y, Yao L, Yu X, Ruan Y, Li Z, Guo J. 2020. Action mechanisms and research methods of tRNA-derived small RNAs. Sig Transduct Target Ther. 5(1):109.
   PubMed Web of Science ®Google Scholar
• Xing YH, Chen LL. 2018. Processing and roles of snoRNA-ended long noncoding RNAs. Crit Rev Biochem Mol Biol. 53(6):596–606.
   PubMed Web of Science ®Google Scholar
• Xiong Z-H, Wei J, Lu M-Q, Jin M-Y, Geng H-L. 2018. Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia. Biomed Pharmacother. 105:1240–1247.
   PubMedGoogle Scholar
• Xu H, Ling M, Xue J, Dai X, Sun Q, Chen C, Liu Y, Zhou L, Liu J, Luo F, et al. 2018. Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking. Theranostics. 8(19):5419–5433.
   PubMed Web of Science ®Google Scholar
• Xu Y, Luo F, Liu Y, Shi L, Lu X, Xu W, Liu Q. 2015. Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. Arch Toxicol. 89(7):1071–1082.
   PubMed Web of Science ®Google Scholar
• Xu Z, Tian P, Guo J, Mi C, Liang T, Xie J, Huang W, Dai M, Chen W, Zhang H. 2021. Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive feedback loop. Sci Total Environ. 776:145950.
   PubMed Web of Science ®Google Scholar
• Xu Z, Wang N, Xu Y, Hua L, Zhou D, Zheng M, Deng X. 2019. Effects of chronic PM exposure on pulmonary epithelia: transcriptome analysis of mRNA-exosomal miRNA interactions. Toxicol Lett. 316:49–59.
   PubMed Web of Science ®Google Scholar
• Xueya Z, Yamei L, Sha C, Dan C, Hong S, Xingyu Y, Weiwei C. 2020. Exosomal encapsulation of miR-125a-5p inhibited trophoblast cell migration and proliferation by regulating the expression of VEGFA in preeclampsia. Biochem Biophys Res Commun. 525(3):646–653.
   PubMed Web of Science ®Google Scholar
• Yang C, Lim W, Park J, Park S, You S, Song G. 2019. Anti-inflammatory effects of mesenchymal stem cell-derived exosomal microRNA-146a-5p and microRNA-548e-5p on human trophoblast cells. Mol Hum Reprod. 25(11):755–771.
   PubMedGoogle Scholar
• Ye Y, Jiang S, Du T, Ding M, Hou M, Mi C, Liang T, Zhong H, Xie J, Xu W, et al. 2021. Environmental pollutant benzo[a]pyrene upregulated long non-coding RNA HZ07 inhibits trophoblast cell migration by inactivating PI3K/AKT/MMP2 signaling pathway in recurrent pregnancy loss. Reprod Sci. 28(11):3085–3093.
   PubMed Web of Science ®Google Scholar
• Ye Y, Jiang S, Zhang C, Cheng Y, Zhong H, Du T, Xu W, Azziz R, Zhang H, Zhao X. 2020. Environmental pollutant benzo[a]pyrene induces recurrent pregnancy loss through promoting apoptosis and suppressing migration of extravillous trophoblast. Biomed Res Int. 2020:8983494.
   PubMed Web of Science ®Google Scholar
• Ying X, Jin X, Zhu Y, Liang M, Chang X, Zheng L. 2020. Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion. Int Immunopharmacol. 88:106981.
   PubMed Web of Science ®Google Scholar
• Yousefi H, Maheronnaghsh M, Molaei F, Mashouri LR., Aref A, Momeny M, Alahari SK. 2020. Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance. Oncogene. 39(5):953–974.
   PubMed Web of Science ®Google Scholar
• Yu B, Zhang Y, Tian Y, Gong S. 2022. Effects of miRNA-modified exosomes alleviate cerebral ischemic reperfusion injury in preclinical studies: a meta-analysis. World Neurosurg. 168:278–286.e272.
   PubMedGoogle Scholar
• Zhan Q, Yi K, Qi H, Li S, Li X, Wang Q, Wang Y, Liu C, Qiu M, Yuan X, et al. 2020. Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy. Theranostics. 10(17):7889–7905.
   PubMedGoogle Scholar
• Zhao J, Cheng L, Liu Q, Liang T, Xie J, Wang R, Chen W, Ao L, Zhang H. 2022. Lnc-HZ03 promotes TRBP-mediated splicing of pre-miR-hz03 to generate miR-hz03 in human trophoblast cells. Toxicol Sci.191(2):332–342
   Google Scholar
• Zhu J, Liu B, Wang Z, Wang D, Ni H, Zhang L, Wang Y. 2019. Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation. Theranostics. 9(23):6901–6919.
   PubMed Web of Science ®Google Scholar