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Research Article

Cytogenetic Effects of Ethylene Oxide, with an Emphasis on Population Monitoring

Pages 263-282 | Published online: 29 Sep 2008

References

  • Au, W. W., Gajas-Salazar, N., and Salama, S., Factors contributing to discrepancies in population monitoring studies. Mutat Res, 1998; 400: 467–478.
  • Appelgren, L.-E., Eneroth, G., Grant, C., Landström, L.-E., and Tenghagen, K., Testing of ethylene oxide for mutagenicity using the micronucleus test in mice and rats. Acta Pharmacol et Toxicol, 1978; 43: 69–71.
  • Barale, R., Chelotti, L., Davini, T., Del Ry, S., Andreassi, M. G., Ballardin, M., Bulleri, M., He, J., Baldacci, S., DiPede, F., Gemigmani, F., and Landi, S., Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian popu- lation. II. Contribution of sex, age and lifestyle. Environ Mol Mutagen, 1998; 31: 228–242.
  • Bastlová, T., Andersson B., Lambert, B., and Kolman, A., Molecular analysis of ethylene oxide-induced muta- tions at the HPRT locus in human diploid fibroblasts. Mutat Res, 1993; 287: 283–292.
  • Bender, M. A., Preston, R. J., Leonard, R. C., Pyatt, B. E., and Gooch, P. C., Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample.II. Extension of age range. Mutat Res, 1988; 212: 149– 154.
  • Bender, M. A., Preston, R. J., Leonard, R. C., Pyatt, B. E., Gooch, P. C., and Shelby, M. D., Chromosomalaberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. Muta Res, 1988; 204: 421–433.
  • Bianchi, M. S., Larramendy, M. L., and Bianchi, N. O., Mitomycin C-induced damage and repair in human and pig lymphocytes. Mutat Res, 1986; 160: 27–32.
  • Clare, M. G., Dean, B. J., de Jong, G., and van Sittert, N. J., Chromosome analysis of lymphocytes from work- ers at an ethylene oxide plant. Mutat Res, 1985; 156: 109–116.
  • de Jong, G., van Sittert, N. J., and Natarajan, A. T., Cy- togenetic monitoring of industrial populations poten- tially exposed to genotoxic chemicals and of control populations. Mutat Res, 1988; 204: 451–464.
  • Director, A. E., Tucker, J. D., Ramsey, M. J., and Nath, J., Chronic ingestion of clastogens by mice and the frequency of chromosome aberrations. Environ Mol Mutagen, 1998; 32: 139–147.
  • Evans, H. J., What has been achieved with cytogenetic moni- toring? In: Monitoring of Occupational Genotoxicants. Sorsa, M. and Norppa, H., Eds. Liss, New York, 1986, 3–23.
  • Farooqi, Z., Törnqvist, M., Ehrenberg, L., and Natarajan, A. T., Genotoxic effects of ethylene oxide and propy- lene oxide in mouse bone marrow cells. Mutat Res, 1993; 288: 223–228.
  • Galloway, S. M., Berry, P. K., Nichols, W. W., Wolman,S. R., Soper, K. A., Stolley, P. D., and Archer, P., Chromsome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control popu- lation. Mutat Res, 1986; 170: 55–74.
  • Garry, V. F., Hozier, J., Jacobs, D., Wade, R. L., and Gray, D. G., Ethylene oxide: Evidence of human chro- mosomal effects. Environ Mutagen, 1979; 1: 375–382. Generoso, W. M., Cain, K. T., Cornett, C. V., Cacheiro,N. L., and Hughes, L. A., Concentration-response curves for ethylene oxide-induced heritable transloca- tions and dominant lethal mutations. Environ Mol Mu- tagen, 1990; 16: 126–131.
  • Generoso, W. M., Cain, K. T., Hughes, L. A., Sega, G. A., Branden, P. W., Gosslee, D. G., and Shelby, M. D., Ethylene oxide dose and dose-rate effects in the mouse dominant-lethal test. Environ Mutagen, 1986; 8: 1–7.
  • Hagmar, L., Bonassi, S., Stromberg, U., Brogger, A., Knudsen, L. E., Norppa, H., and Reuterwall, C., Chromosomal aberrations in lymphocytes predict hu- man cancer: A report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Can- cer Res, 1998 a; 58: 4117–4121.
  • Hagmar, L., Bonassi, S., Stromberg, U., Mikoczy, Z., Lando, C., Hansteen, I. L., Montagud, A. H., Knudsen, L., Norppa, H., Reuterwall, C., Tinnerberg, H., Brogger, A., Forni, A., Hogstedt, B., Lambert, B., Mitelman, F., Nordenson, Salomea, S., and Skerfving, S., Cancer predictive value of cytogenetic markers used in occupational health surveillance pro- grams: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health. Mutat Res, 1998b; 405: 171–178.
  • Hansen, J. P., Allen, J., Block, K., Falconer, J., Helms,M. J., Shaver, G. C., and Strohm, B., Normal sister chromatid exchange levels in hospital sterilization em- ployees exposed to ethylene oxide. J Occup Med, 1984; 26: 29–32.
  • He, S. M. and Lambert, B., Induction and persistence of SCE-inducing damage in human lymphocytes exposed to viryl acetate and acetaldehyde in vitro. Mutat Res, 1985; 158: 201–208.
  • Hiss, E. A. and Preston, R. J., The effect of cytosine arabi- noside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatment. Biochim Biophys Acta, 1977; 478: 1–8.
  • Hogstedt, B., Gullberg, B., Hedner, K., Kolnig, A. M., Mitelman, F., Skerfving, S., and Widegren, B., Chro- mosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans ex- posed to ethylene oxide. Hereditas, 1983; 98: 105–113. International Agency for Research on Cancer (1992), Mechanisms of Carcinogensis in Risk Identification, IARC Scientific Publication No. 116, Lyon, France:IARC.
  • International Agency for Research on Cancer (1994), IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 60, Lyon, France: IARC, pp. 75– 159.
  • Jijima, K. and Morinoto, K., Cell-stage dependence of mutagen-induced sister-chromatid exchanges in human lymphocyte cultures. Mutat Res, 1986; 162: 121–129. Kelsey, K. T., Wiencke, J. K., Eisen, E. A., Lynch, D. W., Lewis, T. R., and Little, J. B., Persistently elevated sister chromatid exchanges in ethylene oxide-exposed primates: the role of a subpopulation of high frequencycells. Cancer Res, 1988; 48: 5045–5050.
  • Kishi, K., Effects of repair inhibition in the G1 phase of clastogen-treated human lymphocytes on the frequen- cies of chromosome-type and chromatid-type aberra- tions and sister-chromatid exchanges. Mutat Res, 1987; 176: 105–116.
  • Kligerman, A. D., Doerr, C. L., and Tennant, A. H., Cell cycle specificity of cytogenetic damage induced by 3,4– epoxy-1–butene. Mutat Res, 1999, in press.
  • Kligerman, A. D., Erexson, G. L., Phelps, M. E., and Wilmer, J. L., Sister-chromatid exchange induction in peripheral blood lymphocytes of rats exposed to ethyl- ene oxide by inhalation. Mutat Res, 1983; 120: 37–44.
  • Kolman, A., Bohusová, T., Lambert, B., and Simons, J. W. I. M., Induction of 6–thioguanine-resistant mu- tants in human diploid fibroblasts in vitro with ethylene oxide. Environ Mol Mutagen, 1992; 19: 9397.
  • Lambert, B., Sten, M., Hellgren, D., and Francesioni, D., Different SCE-inducing effects of HN2 and MMS in early and late G1 in human lymphocytes. Mutat Res, 1984; 139: 71–77.
  • Laurent, C., SCE increases after an accidental acute inhala- tion exposure to EtO and recovery to normal after 2 years. Mutat Res, 1988; 204: 711–717.
  • Laurent, Ch., Frederic, J., and Marechal, F., Increased sister chromatid exchange frequency in workers exposed to ethylene oxide. Ann Genet, 1983; 26: 138–142.
  • Lerda, D. and Rizzi, R., Cytogenetic study of persons oc- cupationally exposed to ethylene oxide. Mutat Res, 1992; 281: 31–37.
  • Lucas, J. N., Awa, A., Straume, T., Poggensee, M.,Uodama, Y., Nakano, M., Ohtaki, K., Weier, H. U., Pinker, D., Gray, J., and Littlefield, L. G., Rapid translocation analysis in humans decades after expo- sure to ionizing radiation. Int J Radiat Biol, 1992; 62: 53–63.
  • Lynch, D. W., Lewis, T. R., Moorman, W. J., Burg, J. R., Gulati, D. K., Kaur, P., and Sabharwal, P. S., Sister- chromatid exchanges and chromosome aberrations in lymphocytes from monkeys exposed to ethylene oxide and propylene oxide by inhalation. Toxicol Appl Pharmacol, 1984; 76: 85–95.
  • Major, J., Jakab, M. G., and Tompa, A., Genotoxicological investigation of hospital nurses occupationally exposed to ethylene-oxide. 1. Chromosome aberrations, sister- chromatid exchanges, cell cycle kinetics, and UV-in- duced DNA synthesis in peripheral blood lymphocytes. Environ Mol Mutagen, 1996; 27: 84–92.
  • Mayer, J., Warburton, D., Jeffrey, A. M., Pero, R., Walles, S., Andrews, L., Toor, M., Latriano, L., Wazneh, L.,Tang, D., Tsai, W. Y., Kuroda, M., and Perera, F., Biologic markers in ethylene oxide-exposed workers and controls. Mutat Res, 1991; 248: 163–176.
  • McFee, A. F., Lowe, K. W., and San Sebastian, J. R., Improved sister-chromatid differentiation using paraf- fin-coated bromodeoxyuridine tables in mice. Mutat Res, 1983; 119: 83–88.
  • Ong, T., Bi, H.-K., Xing, S., Stewart, J. and Moorman, W., Induction of sister chromatid exchange in spleen and bone marrow cells of rats exposed by inhalation to different dose rates of ethylene oxide. Environ Mol Mutagen, 1993; 22: 147–151.
  • Perry, P. and Evans, H. J., Cytological detection of mu- tagen-carcinogen exposure by sister chromatid exchange. Nature, 1975; 258: 121–125.
  • Popp, W., Vahrenholz, C., Przygoda, H., Brauksiepe, A., Goch, S., Muller, G., Schell, C., and Norpoth, K., DNA-protein cross-links and sister chromatid exchange frequencies in lymphocytes and hydroxyethyl mercap- turic acid in urine of ethylene oxide-exposed hospital workers. Int Arch Occup Environ Health, 1994; 66: 325–332.
  • Preston, R. J. and Gooch, P. C., The induction of chromo- some-type aberrations in G1 by methyl methanesulfonate and 4–nitroguinoline-N-oxide, and the non-requirement of an S-phase for their induction. Mutat Res, 1981; 83: 395–402.
  • Ramsey, M. J., Moore, D. H., Briner, J. F., Lee, D. A., Olsen, La., Senft, J. R., and Tucker, J. D., The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome paint- ing. Mutat Res, 1995; 338: 95–106.
  • Ribeiro, L. R., Rabello-Gay, M. N., Salvadori, D. M. F, Pereira, C. A. B., and Beçak,W., Cytogenetic effects of inhaled ethylene oxide in somatic and germ cells of mice. Arch Toxicol, 1987; 59: 332–335.
  • Ribeiro, L. R., Salvadori, D. M. F., Rios, A. C. C., Costa,S. L., Tates, A. D., Tornqvist, M., and Natarajan,A. T., Biological monitoring of workers occupationally exposed to ethylene oxide. Mutat Res, 1994; 313: 81– 87.
  • Sarto, F., Clonfero, E., Bartolucci, G. B., Franceschi, C., Chiricolo, M., and Levis, A. G., Sister chromatid ex- changes and DNA repair capability in sanitary workers exposed to ethylene oxide: Evaluation of the dose-ef- fect relationship. Am J Ind Med; 1987;12:625–637.
  • Sarto, F., Cominato, I., Pinton, A. M., Brovedani, P. G., Faccioli, C. M., Bianchi, V., and Levis, A. G., Cyto- genetic damage in workers exposed to ethylene oxide. Mutat Res, 1984; 138: 185–195.
  • Sarto, F., Tomanin, R., Giacomelli, L., Iannini, G., and Cupiraggi, A. R., The micronucleus assay in human exfoliated cells of the nose and mouth: application to occupational exposures to chromic acid and ethylene oxide. Mutat Res, 1990; 244: 345–351.
  • Sarto, F., Tornqvist, M. A., Tomanin, R., Bartolucci, G. B., Osterman-Golkar, S. M., and Ehrenberg, L., Studies of biological and chemical monitoring of low-level ex- posure to ethylene oxide. Scand J Work Environ Health, 1991; 17: 60–64.
  • Schulte, P. A., Walker, J. T., Boeniger, M. F., Tsuchiya, Y., and Halperin, W. E., Molecular, cytogenetic, and hematologic effects of ethylene oxide on female hospi- tal workers. J. Occup Environ Med, 1995; 37: 313–320.
  • Schulte, P. A., Boeniger, M., Walker, J. T., Schober, S. E., Pereira, M. A., Gulati, D. K., Wojciechowski, J. P., Garza, A., Froelich, R., Strauss, G., Halperin, W. E., Herrick, R., and Griffith, J. Biologic markers in hos- pital workers exposed to low levels of ethylene oxide. Mutat Res, 1992; 278: 237–251.
  • Scott, D. and Lyons, C. Y., Homogenous sensitivity of human peripheral blood lymphocytes to radiation-in- duced chromosome damage. Nature, 1979; 278: 756–758.
  • Shaham, J., Shabtai, P., and Ribak, J., Cytogenetic changes in ethylene oxide-exposed workers: a challenge to oc- cupational medicine. Israel J Med Sci, 1992; 28: 602–604.
  • Smith, M. T., Zhang, L., Wang, Y., Hayes, R. B., Li, G., Wiemels, J., Dosemeci, M., Titenko-Holland, N., Xi, L., Kolachana, P., Yin, S., and Rothman, N., In- creased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res, 1998; 58: 2176–2181.
  • Stolley, P. D., Soper, K. A., Galloway, S. M., Nichols,W. W., Norman, S. A., and Wolman, S. R., Sister- chromatid exchanges in association with occupational exposure to ethylene oxide. Mutat Res, 1984; 129: 89– 102.
  • Tates, A. D., Boogaard, P. J., Darroudi, F., Natarajan,A. T., Caubo, M. E., and van Sittert, N. J., Biological effect monitoring in industrial workers following inci-dental exposure to high concentrations of ethylene ox- ide. Mutat Res, 1995; 329: 63–77.
  • Tates, A. D., Grummt, T., Tornqvist, M., Farmer,P. B., van Dam, F. J., van Mossel, H., Schoemaker,H. M., Osterman-Golkar, S., Uebel, Ch., Tang,Y. S., Zwinderman, A. H., Natarajan, A. T., and Ehrenberg, L., Biological and chemical monitoring of occupational exposure to ethylene oxide. Mutat Res, 1991; 250: 483–497.
  • Tates, A. D., Grummt, T., van Dam, F. J., de Zwart, F., Kasper, F. J., Rothe, R., Stirn, H., Zwinderman,A. H., and Natarajan, A. T., Measurement of frequen- cies of HPRT mutants, chromosomal aberrations, mi- cronuclei, sister-chromatid exchanges and cells with high frequencies of SCEs in styrene/dichloromethane- exposed workers. Mutat Res, 1994; 313: 249–262.
  • Thiess, A. M., Schwegler, H., Fleig, I., and Stocker, W. G., Mutagenicity study of workers exposed to alkylene oxides (ethylene oxide/propylene oxide) and deriva- tives. J Occup Med, 1981; 23: 343–347.
  • Tice, R., Summary report on the performance of the in vivo sister chromatid exchange assays. In: Report of Interna- tional Program on Chemical Safety (IPCS) Collabora- tive Study, Evaluation of Short-Term Tests for Carcinogens, Ashby, J., de Serres, F. J., Shelby, M. D., Margolin, B. H., Ishidate, M., and Becking, G. C., EDS., Cambridge, 1989; 1233–1253.
  • Tomkins, D. J., Haines, T., Lawrence, M., and Rosa, N., A study of sister chromatid exchange and somatic cell mutation in hospital workers exposed to ethylene oxide. Environ Health Perspect Suppl, 1993; 101: 159–164.
  • Tucker, J. D., Eastmond, J. D., and Littlefield, L. G., Cytogenetic end-points as biological dosimeters and predictors of risk in epidemiological studies, In: IARC Scientific Publication 142, Lyon, France. IARC, 1997; pp. 185–200.
  • van Sittert, N. J., de Jong, G., Clare, M. G., Davies, R., Dean, B. J., Wren, L. J., and Wright, A. S., Cytoge- netic, immunological, and haematological effects in workers in an ethylene oxide manufacturing plant. Br J Ind Med, 1985; 42: 19–26.
  • Yager, J. W., Effect of concentration-time parameters on sister-chromatid exchanges induced in rabbit lympho- cytes by ethylene oxide inhalation. Mutat Res, 1987; 182: 343–352.
  • Yager, J. W. and Benz, R. D., Sister chromatid exchanges induced in rabbit lymphocytes by ethylene oxide after inhalation exposure. Environ Mutagen, 1982; 4: 121–134.
  • Yager, J. W., Hines, C. J., and Spear, R. C., Exposure to ethylene oxide at work increases sister chromatid ex- changes in human peripheral lymphocytes. Science, 1983; 219: 1221–1223.
  • Zhong, B. Z., Gu, Z. W., Whong, W. Z., Wallace W. E., and Ong, T. M., Comparative study of micronucleus assay and chromosomal aberration analysis in V79 cells exposed to ethylene oxide. Teratog, Carcinogin, Mu- tagen, 1992; 11: 227–233.

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