Frankincense: an ancient oil in the modern world

References

• J.A. von Fraunhofer, Essential Oils from the Ground Up. LifeRich Publications, Bloomington, IN (2019). New Leaf Media, Columbus, OH (2021)
   Google Scholar
• N.H. Aboelsoud, Herbal medicine in ancient Egypt. Journal of Medicinal Plants Research, 4, 82–86 (2010)
   Google Scholar
• J.A. von Fraunhofer and R.K. Joshi, Essential oils and the legislative landscape. American Journal of Essential Oils and Natural Products, 7, 1–6 (2019)
   Google Scholar
• A. Moussaieff and R. A, Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials. The Journal of Pharmacy and Pharmacology, 61(10), 1281–1293 (2009). https://doi.org/10.1211/jpp/61.10.0003
   PubMed Web of Science ®Google Scholar
• J. Niebler and A. Buettner, Identification of odorants in frankincense (Boswellia sacra flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography–mass spectrometry/olfactometry. Phytochemistry, 109, 66–75 (2015). https://doi.org/10.1016/j.phytochem.2014.10.030
   PubMedGoogle Scholar
• M.L. Grbić, N. Unković, I. Dimkić I, P. Janaćković, M. Gavrilović, O. Stanojević, M. Stupar, L. Vujisić, A. Jelikić, S. Stanković and J. Vukojević, Frankincense and myrrh essential oils and burn incense fume against micro-inhabitants of sacral ambients. Wisdom of the ancients?. Journal of Ethnopharmacology, 219, 1–14 (2018). https://doi.org/10.1016/j.jep.2018.03.003
   PubMedGoogle Scholar
• J. Niebler, K. Zhuravlova M. Minceva and A. Buettner, Fragrant sesquiterpene ketones as trace constituents in frankincense volatile oil of Boswellia sacra. Journal of Natural Products, 79(4), 1160–1164 (2016). https://doi.org/10.1021/acs.jnatprod.5b00836
   PubMed Web of Science ®Google Scholar
• A.R.M. Al-Yasiry and B. Kiczorowska, Frankincense – therapeutic properties. Postępy Higieny I Medycyny Doświadczalnej, 70, 380–391 (2016). https://doi.org/10.5604/17322693.1200553
   Google Scholar
• P. James and N. Thorpe, Ancient Inventions. Ballantine Books, New York, NY (2015)
   Google Scholar
• S. Marshall, Festive pharmacognosy. The Pharmaceutical Journal, 271, 862–864 (2003)
   Google Scholar
• D. Stewart, The Chemistry of Essential Oils Made Simple. Care Publications, Marble Hill, MO (2006)
   Google Scholar
• R. Hamidpour, S. Hamidpour and M. Hamidpour, Chemistry, pharmacology and medicinal property of frankincense (Boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases. Global Journal of Medical Research 15, XV(Issue III):14–22 (2015). Online ISSN: 2249-4618 & Print ISSN: 0975-5888.
   Google Scholar
• S. Noroozi, H.K. Haghighian and M. Abbasi, A review of the therapeutic effects of frankincense. J Qazvin Univ Med Sci, 22(1), 70–81 (2018)
   Google Scholar
• A.J. Khan, Medicinal properties of frankincense. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(2), 79 (2012). https://doi.org/10.4103/2231-0738.95925
   Google Scholar
• L. Rashan, F. L. Hakkim, M. Idrees, M. Essa, T. Velusamy, M. Al-Baloshi, B. Al-Bulushi, A. Al Jabri, M. Alrizeiki, G. Guillemin and S.S. Abdo Hasson, Boswellia gum resin and essential oils: potential health benefits − an evidence based review. International Journal of Nutrition, Pharmacology, Neurological Diseases, 9(2), 53–71 (2019). https://doi.org/10.4103/ijnpnd.ijnpnd_11_19
   Google Scholar
• C. Cuaz-Peérolin, L. Billiet, E. Baugeé, C. Copin, D. Scott-Algara, F. Genze, B. Buüchele, T. Syrovets, T. Simmet and M. Rouis, Antiinflammatory and antiatherogenic effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic acid in LPS-challenged ApoE −/− Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(2), 272–277 (2008). https://doi.org/10.1161/ATVBAHA.107.155606
   PubMedGoogle Scholar
• A. Moussaieff, A. Trembovler, Y. Ben-Neriah, S. Grigoriadis, C. Simeonidou, A.G. Alexandrovich, V. Trembovler, Y. Ben-Neriah, M.L. Schmitz, B.L. Fiebich, E. Munoz, R. Mechoulam and E. Shohami, Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii. Journal of Cerebral Blood Flow & Metabolism, 28(7), 1341–1352 (2008). https://doi.org/10.1038/jcbfm.2008.28
   PubMed Web of Science ®Google Scholar
• A. Moussaieff, M. Gross, E. Nesher, T. Tikhonov, G. Yadid and A. Pinhasov, Incensole acetate reduces depressive-like behavior. Journal of Psychopharmacology, 26(12), 1584–1593 (2012). https://doi.org/10.1177/0269881112458729
   PubMedGoogle Scholar
• A. Moussaieff, J. Yu, H. Zhu, S. Gattoni-Celli, E. Shohami and M.S. Kindy, Incensole acetate protective against cerebral ischaemic injury. Brain Research, 1443, 89–97 (2012). https://doi.org/10.1016/j.brainres.2012.01.001
   PubMed Web of Science ®Google Scholar
• A. Moussaieff, N.A. Shein, J. Tsenter, S. Grigoriadis, C. Simeonidou, A.G. Alexandrovich, V. Trembovler, Y. Ben-Neriah, M.L. Schmitz, B.L. Fiebich, E. Munoz, R. Mechoulam and E. Shohami, Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii. Journal of Cerebral Blood Flow & Metabolism, 28(7), 1341–1352 (2008)
   PubMed Web of Science ®Google Scholar
• A. Moussaieff, N. Rimmerman, T. Bregman, A. Straiker, C.C. Felder, S. Shoham, Y. Kashman, S.M. Huang, H. Lee, E. Shohami, K. Mackie, M.J. Caterina, J.M. Walker, E. Fride and R. Mechoulam, Incensole acetate elicits psychoactivity by activating brain TRPV3 channels. The FASEB Journal, 22(8), 3024–3034 (2008). https://doi.org/10.1096/fj.07-101865
   PubMed Web of Science ®Google Scholar
• Y.-L. Lee, Y. Wu, W.H. Hector, A.Y. Leung and W.M. Cheung, A systematic review on the anxiolytic effects of aromatherapy in people with anxiety symptoms. The Journal of Alternative and Complementary Medicine, 17(2), 101–108 (2011). https://doi.org/10.1089/acm.2009.0277
   PubMedGoogle Scholar
• A. Ghiasi, L. Bagheri and A. Haseli, A systematic review on the anxiolytic effect of aromatherapy during the first stage of labor. Journal of Caring Sciences, 8(1), 51–60 (2019). https://doi.org/10.15171/jcs.2019.008
   PubMedGoogle Scholar
• Y. Chen, C. Zhou, Z. Ge, Y. Liu, Y. Liu, W. Feng, S. Li, G. Chen and T. Wei, Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense. Oncology Letters, 6(4), 1140–1146 (2013). https://doi.org/10.3892/ol.2013.1520
   PubMed Web of Science ®Google Scholar
• T. Efferth and H.J. Greten, Anti-Inflammatory and anti-cancer activity of Boswellic acids from frankincense (Boswellia serrata Roxb. et Colebr, B. carterii Birdw.). Forum on Immunopathological Diseases and Therapeutics, 2(4), 303–313 (2011). https://doi.org/10.1615/ForumImmunDisTher.2012004432
   Google Scholar
• T. Efferth and F. Oesch, Anti-Inflammatory and anti-cancer activities of frankincense: targets, treatments and toxicities. Seminars in Cancer Biology (4 February 2020). https://doi.org/10.1016/j.semcancer.2020.01.015
   Google Scholar
• M.B. Frank, Q. Yang, J. Osban, J.T. Azzarello, M.R. Saban, R. Saban, R.A. Ashley, J.C. Welter, K.-M. Fung and H.-K. Lin, Frankincense oil derived from Boswellia carterii induces tumor cell specific cytotoxicity. BMC Complementary and Alternative Medicine, 9(1), 6–10 (2009). https://doi.org/10.1186/1472-6882-9-6
   PubMedGoogle Scholar
• M.M. Suhail, W. Wu, A. Cao, F.G. Mondalek, K.-M. Fung, P.-T. Shih, Y.-T. Fang, C. Woolley, G. Young and H.-K. Lin, Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complementary and Alternative Medicine, 11(1), 129–143 (2011). https://doi.org/10.1186/1472-6882-11-129
   PubMedGoogle Scholar
• K.M. Fung, M.M. Suhail B. McClendon, C.L. Woolley, D.G. Young and H.K. Lin, Management of basal cell carcinoma of the skin using frankincense (Boswellia sacra) essential oil: a case report. OA Alternative Medicine, 1(2), 14–18 (2013). https://doi.org/10.13172/2052-7845-1-2-656
   Google Scholar
• P. Ren, X. Ren, L. Cheng and L. Xu, Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer. Oncology Reports, 39(1), 129–137 (2018). https://doi.org/10.3892/or.2017.6067
   PubMed Web of Science ®Google Scholar
• F.L. Hakkim, H.A. Bakshi, S. Khan, M. Nasef, R. Farzand, S. Sam, L. Rashan, M.S. Al-Baloshi, S.S.A. Abdo Hasson, A.A. Jabri, P.A. McCarron and M.M. Tambuwala, Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes. Oncotarget, 10(37), 3472–3490 (2019). https://doi.org/10.18632/oncotarget.26930
   PubMedGoogle Scholar
• D. Schillaci, V. Arizza, T. Dayton, L. Camarda and V.D. Stefano, In vitro anti-biofilm activity of Boswellia spp. oleogum resin essential oils. Letters in Applied Microbiology, 47(5), 433–438 (2008). https://doi.org/10.1111/j.1472-765X.2008.02469.x
   PubMedGoogle Scholar
• A.F. Raja, F. Ali, I.A. Khan, A.S. Shawl, D.S. Arora, B.A. Shah and S.C. Taneja, Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata. BMC Microbiology, 11(1), 54–87 (2011). https://doi.org/10.1186/1471-2180-11-54
   PubMed Web of Science ®Google Scholar
• J.A. von Fraunhofer and Z.G. Loewy, Factors involved in microbial colonization of oral prostheses. General Dentistry, 57(2), 136–143 (2009)
   PubMedGoogle Scholar
• M.K. Samani, H. Mahmoodian, A.A. Moghadamnia, A. Poorsattar Bejeh Mir and M. Chitsazan, The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical trial. Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 19(4), 288–294 (2011)
   PubMedGoogle Scholar
• S.M.M. Sabra and L.M.R. Al-Masoudi, The effect of using Frankincense (Boswellia sacra) chewing gum on the microbial contents of Buccal/Oral Cavity, Taif, KSA. IOSR Journal of Dental and Medical Sciences, 13(4), 77–82 (2014). https://doi.org/10.9790/0853-13417782
   Google Scholar
• M.E.I. Aldory, F.F. Ali and S.M. Sultan, Effect of watery and alcoholic extract of frankincense on the candida albicans fungus. International Journal of Pharmaceutical Research & Allied Sciences, 7, 56–62 (2018)
   Google Scholar
• S.F. Van Vuuren, G.P.P. Kamatou and A.M. Viljoen, Volatile composition and antimicrobial activity of twenty commercial frankincense essential oil samples. South African Journal of Botany, 76(4), 686–691 (2010). https://doi.org/10.1016/j.sajb.2010.06.001
   Web of Science ®Google Scholar
• S.M. Ismail, S. Aluru and K.R.S. Sambasivarao, Antimicrobial activity of frankincense of Boswellia serrata. International Journal of Current Microbiology and Applied Sciences, 3, 1095–1101 (2014)
   Google Scholar
• A. Al-Harrasi, H. Hussain, R. Csuk and H.Y. Khan, Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia. Elsevier, Amsterdam (2018)
   Google Scholar
• K.G. Byler and W.N. Setzer, Protein targets of Frankincense: a reverse docking analysis of terpenoids from Boswellia Oleo-Gum Resins. Medicines, 5(3), 96–134 (2018). https://doi.org/10.3390/medicines5030096
   Google Scholar
• X. Han, D. Rodriguez and T.L. Parker, Biological activities of frankincense essential oil in human dermal fibroblasts. Biochimie Open, 4, 31–35 (2017). https://doi.org/10.1016/j.biopen.2017.01.003
   PubMedGoogle Scholar
• S. Su, J. Duan, T. Chen, X. Huang, E. Shang, L. Yu, K. Wei, Y. Zhu, J. Guo, S. Guo, P. Liu, D. Qian and Y. Tang, Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway. Scientific Reports, 5(1), 13668 (2015). https://doi.org/10.1038/srep13668
   PubMedGoogle Scholar
• R. Eshaghian, M. Mazaheri, M. Ghanadian, S. Rouholamin, A. Feizi and M. Babaeian, The effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) on heavy menstrual bleeding: a randomized, placebo-controlled, clinical trial. Complementary Therapies in Medicine, 42, 42–47 (2019). https://doi.org/10.1016/j.ctim.2018.09.022
   PubMed Web of Science ®Google Scholar
• A. Moussaieff, E. Shohami, Y. Kashman, E. Fride, M.L. Schmitz, F. Renner, B.L. Fiebich, E. Munoz, Y. Ben-Neriah and R. Mechoulam, Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia Resin, inhibits nuclear factor-κB activation. Molecular Pharmacology, 72(6), 1657–1664 (2007). https://doi.org/10.1124/mol.107.038810
   PubMedGoogle Scholar
• P.J. Barnes, Nuclear factor-κB. The International Journal of Biochemistry & Cell Biology, 29(6), 867–870 (1997). https://doi.org/10.1016/S1357-2725(96)00159-8
   PubMedGoogle Scholar
• L.M. Jarvis, IL-6 blockers tested against COVID-19. Chemical and Engineering News, 98(11):13 (2020).
   Google Scholar
• M.G. Dozmorov, Q. Yang, W. Wu, J. Wren, M.M. Suhail, C.L. Woolley, D.G. Young, K.-M. Fung and H.-K. Lin, Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study. Chinese Medicine, 9(1), 18–30 (2014). https://doi.org/10.1186/1749-8546-9-18
   PubMedGoogle Scholar
• S.M.U. Ahmed, L. Luo and A. Namani, Nrf2 signaling pathway: pivotal roles in inflammation. Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease, 2, 1863–597585–597 (2017)
   Google Scholar