Convenient synthesis of α-diarylmethylphosphonates by HOTf catalyzed Friedel-Crafts arylation of α-aryl α-hydroxyphosphonates

References

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• We also tried the reaction of simple benzene and other arenes with electronwithdrawing group such as bromobenzene, chlorobenzene with α-hydroxyphosphonate 1a, but found most of 1a underwent the retro-Pudovik reaction under the strong acid conditions. Meanwhile, due to the low nucleophilicity of these arenes (benzene, bromobenzene and chlorobenzene), the Friedel-Crafts arylation between 1a and these arenes could hardly proceed, which resulted in no desired arylated product detected.
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