Synthesis of vinca alkaloid–triphenylphosphine derivatives having potential antitumor effect

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• Appearance: white, crystalline. Mp 70–74 °C. TLC (dichloromethane-methanol =20:1); Rf = 0.60. IR (KBr): 2963, 1738, 1616, 1598, 1502, 1435, 1247, 1225, 1168, 1121, 1028 cm−1.
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• Appearance: pale pink, crystalline. Mp 157–161 °C. TLC (dichloromethane-methanol =20:1); Rf = 0.14. IR (KBr): 3397, 2875, 1735, 1438, 1249, 1113, 742, 508 cm−1.
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• Appearance: pale pink, crystalline. Mp 112–116 °C. TLC (dichloromethane-methanol =20:1); Rf = 0.09. IR (KBr): 3391, 2932, 1735, 1615, 1501, 1438, 1249, 1112, 691, 531 cm−1.
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