BISPHOSPHONIC COMPOUNDS. IV.¹ PREPARATION AND IDENTIFICATION OF MIXED TETRAALKYL METHYLENE- AND (DICHLOROMETHYLENE)-BISPHOSPHONATES BY NMR SPECTROSCOPIC, MASS SPECTROMETRIC AND X-RAY CRYSTALLOGRAPHIC STUDIES

References

• Vepsäläinen , J. , Nupponen , H. , Pohjala , E. , Ahlgren , M. and Vainiotalo , P. 1992 . J. Chem. Soc. Perkin Trans. , 2 : 835
   Google Scholar
• Fleisch , H. 1983 . Bone and Mineral Research , Edited by: Peck , W. A. Amsterdam : Medica . Annual 1. Excerpta
   Google Scholar
• Ebetino , F. H. , Degenhardt , C. R. , Jamieson , L. A. and Burdsall , D. C. 1990 . Heterocycles , 30 : 855 See e.g.
   Google Scholar
• Sietsema , W. K. , Ebetino , F. H. , Salvagno , A. M. and Bevan , J. A. 1989 . Drugs Exptl. Clin. Res. , XV : 389
   Google Scholar
• Nguyen , L. M. , Niesor , E. and Bentzen , C. L. 1987 . J. Med. Chem. , 30 : 1426
   PubMed Web of Science ®Google Scholar
• Proctor & Gamble Co.-Belg. Patent 672,205 . 1966 .
   Google Scholar
• Hannuniemi , R. , Laurén , L. and Puolijoki , H. 1991 . Drugs of Today , 27 : 375 For recent reviews see
   Google Scholar
• Kanis , J. A. and McCloskey , E. V. 1990 . Prog. Basic Clin. Pharmacol. , 4 : 89
   Google Scholar
• McKenna , C. E. , Khawli , L. A. , Ahmad , W.-Y. , Pham , P. and Bongartz , J.-P. 1988 . Phosphorus and Sulfur , 37 : 1
   Web of Science ®Google Scholar
• Hutchinson , D. and Semple , G. 1985 . J. Organomet. Chem. , 291 : 145
   Web of Science ®Google Scholar
• Hutchinson , D. and Semple , G. 1984 . Phosphorus and Sulfur , 21 : 1
   Web of Science ®Google Scholar
• Kukhar , V. and Sagina , E. 1979 . Zh. Obshch. Khim. , 49 : 1470
   Google Scholar
• Seyferth , D. and Marmor , R. 1973 . J. Organomet. Chem. , 59 : 237
   Web of Science ®Google Scholar
• Moedritzer , K. and Irani , R. R. 1961 . J. Inorg. Nucl. Chem. , 22 : 297
   Web of Science ®Google Scholar
• Siddall , T. H. and Prohaska , C. A. 1965 . Inorg. Chem. , 4 : 783
   Google Scholar
• Lang , G. and Herrmann , E. 1986 . Z. Anorg. Allg. Chem. , 536 : 187
   Google Scholar
• Teulade , M.-P. , Savignac , P. , Aboujaoude , E. E. , Liétge , S. and Collignon , N. 1986 . J. Organomet. Chem. , 304 : 283
   Web of Science ®Google Scholar
• Bartlett , P. A. , Carruthers , N. I. , Winter , B. M. and Long , K. P. 1982 . J. Org. Chem. , 47 : 1284
   Web of Science ®Google Scholar
• Bartlett , P. A. and Long , K. P. 1977 . J. Am Chem. Soc. , 99 : 1267
   Google Scholar
• Vaghefi , M. M. , Bernacki , R. J. , Hennen , W. J. and Robins , R. K. 1987 . J. Med. Chem. , 39 : 1391
   Google Scholar
• Müller , E. 1964 . Methoden Der Organischen Chemie (Houben-Weyl) , vol 12/2 , 53 – 77 . Stuttgart, , Germany : Georg Thieme Verlag .
   Google Scholar
• Methoden Der Organischen Chemie (Houben-Weyl) vol. 12/1 , 433 – 447 .
   Google Scholar
• Methoden Der Organischen Chemie (Houben-Weyl) 387 – 406 .
   Google Scholar
• Methoden Der Organischen Chemie (Houben-Weyl) vol 12/2 , 286 – 90 .
   Google Scholar
• Methoden Der Organischen Chemie (Houben-Weyl) Vol E2 , 535 – 41 .
   Google Scholar
• Methoden Der Organischen Chemie (Houben-Weyl) vol 12/1 , 448 – 52 .
   Google Scholar
• Morita , T. , Okamoto , Y. and Sakurai , H. 1980 . Chem. Lea. , 435
   Google Scholar
• Cadogan , J. I. G. , Challis , J. A. and Eastlick , D. T. 1971 . J. Chem. Soc. (B) , : 1988
   Google Scholar
• Pelchowicz , Z. 1961 . J. Chem. Soc. , : 238
   Web of Science ®Google Scholar
• Ylagan , L. , Benjamin , A. , Gupta , A. and Engel , R. 1988 . Synth. Commun. , 18 : 285
   Web of Science ®Google Scholar
• Thuong , N. T. , Convert , F. , Martin , G. and Chabrier , P. 1965 . Bull. Soc. Chim. Fr. , : 1925
   Google Scholar
• Christol , H. , Levy , M. and Marty , C. 1968 . J. Organomet. Chem. , 12 : 459
   Web of Science ®Google Scholar
• Koch , P. , Rumpel , H. , Sutler , P. and Weis , C. D. 1989 . Phosphorus and Sulfur , 44 : 75
   Web of Science ®Google Scholar
• Vepsäläinen , J. , Nupponen , H. and Pohjala , E. 1992 . Synth. Commun. , 22 : 271
   Google Scholar
• Deronet , D. , Piatti , T. and Brosse , J. C. 1986 . Eur. Polym. J. , 22 : 963
   Google Scholar
• Gajda , T. and Zwierzak , A. 1976 . Synthesis , 243
   Google Scholar
• Troev , K. and Roundhill , D. M. 1988 . Phosphorus and Sulfur , 37 : 243
   Web of Science ®Google Scholar
• Kluba , M. and Zwierzak , A. 1978 . Synthesis , : 134
   Web of Science ®Google Scholar
• Froneman , M. and Modro , T. A. 1988 . Tetrahedron Lett. , 29 : 3327
   Web of Science ®Google Scholar
• Froneman , M. and Modro , T. A. 1991 . Synthesis , : 201
   Google Scholar
• Blackburn , G. , England , D. and Kolkmann , F. 1981 . J. Chem. Soc. Chem. Comm. , 930
   Google Scholar
• Grey , G. A. 1971 . J. Am. Chem. Soc. , 93 : 2132
   Google Scholar
• Thiem , J. and Meyer , B. 1978 . Org. Magn. Reson. , 11 : 50
   Web of Science ®Google Scholar
• Griffiths , W. and Tebby , J. 1978 . Phosphorus and Sulfur , 5 : 101
   Web of Science ®Google Scholar
• Zeller , L. , Farrell , J. , Vainiotalo , P. and Kenttämaa , H. 1992 . J. Am. Chem. Soc. , 114 : 1205
   Google Scholar
• 1988 . Madison, Wisconsin : Nicolet Co. . SHELXTL PLUS (Release 3.4
   Google Scholar
• Ford-Moore , A. H. and Perry , B. J. 1967 . Organic Syntheses , Edited by: Rabjohn , N. Vol. IV , 325 – 7 . New York : John Wiley & Sons .
   Google Scholar
• Accurate mass measurements were not obtained from the molecular ion or from individual characteristic fragments due to low intentities
   Google Scholar
• Only the 31P NMR signals were clearly resolved from starting material signals
   Google Scholar