- Tsujimoto, Y., Cossman, J., Jaffe, E. and Grace, C.M. (1985) "Involvement of the bcl-2 gene in human follicular lymphoma", Science 228(4706), 1440-1443.
- Tsujimoto, Y. and Croce, C.M. (1986) "Analysis of the structure transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma", Proc. Natl Acad. Sci. USA 83(14), 5214-5218.
- Miyashita, T. and Reed, J.C. (1992) "Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs`", Cancer Res. 52(19), 5407-5411.
- Bissonnette, R.K, Echeverri, F., Mahboubi, A. and Green, D.R. (1992) "Apoptotic cell death induced by c-myc is inhibited by bcl-2", Nature 359(6395), 552-554.
- Garcia, I., Martinou, J., Tsujimoto, Y. and Martinou, J.C. (1992) "Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene", Science 258(5080), 302-304.
- Hockenbery, D.M. (1992) "The bcl-2 oncogene and apoptosis", Semin, Immunol. 4(6), 413-420.
- Korsmeyer, S.J. (1992) "Bcl-2: an antidote to programmed cell death", Cancer Surv 15, 105-118.
- Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R.D. and Korsmeyer, S.J. (1990) "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death", Nature 348(6299), 334-336.
- Monaghan, P., Robertson, D., Amos, T.A., Dryer, M.J., Mason, D. Y. and Greaves, M.F. (1992) "Ultrastructural localization of bcl-2 protein", J. Histochem. Cytochem. 40(12), 1819-1825.
- Hockenbery, D.M., Oltvai, Z.N., Yin, X.M., Milliman, C.L. and Korsmeyer, S.J. (1993) "Bcl-2 functions in an antioxidant pathway to prevent apoptosis", Cell 75(2), 241-251.
- Krajewski, S., Tanaka, S., Takayama, S., Schibier, M.J., Fenton and Reed, J.C (1993) "Investigation of me subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum. and outer mitochondrial membranes", Cancer Res. 53(19), 4701-4714.
- Adachi, S., Cross, A.R., Babior, B.M. and Gottlieb, R.A. (1997) "Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during has-mediated apoptosis", J. Biol. Chem. 272(35), 21878-21882.
- Reed, J.C. (1995) "Bcl-2: prevention of apoptosis as a mechanism of drug resistance`", Hematol. Oncol. Clin. N. Am. 9(2), 451-473.
- Miyashita, T. and Reed, J.C. (1993) "Bcl-2 oncoprotein blocks chemotherapy-induced apopiosis in a human leukemia cell line", Blood 81(1), 151-157.
- Thomas, A., EI Rouby, S., Reed, J.C, Krajewski, S., Silber, R., Potmesil, M. and Newcomb, H.W. (1996) "Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance", Oncogene 12(5), 1055-1062.
- McConkey, D.J., Chandra, J., Wright, S., Plunkett, W., McDonnel, T.J., Reed, J.C. and Keating, A., (1996) "Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of Bcl-2 and BAX", J. Immunol. 156(7), 2624-2630.
- Gibson, L.F., Fortney, J., Magro, G., Ericson, S.G., Lynch, J.P. and Landreth, K.S. (1999) "Regulation of BAX and Bcl-2 expression in breast cancer cells by chemotherapy", Breast Cancer Res. Treat. 55(2), 107-117.
- Cheng, E.H., Kirsch, D.G., Clem, R.J., Ravi, R.,Kastan, M.B., Bendi, A., Ueno, K. and Hardwick, J.M. (1997) "Conversion of BcI-2 to a Bax-like death effector by caspases", Science 278(5345), 1966-1968.
- Fadeel, B., Hassan, Z., Hellstrom-Lindberg, E., Henter, J.I., Onrenius, S. and Zhivotovsky, B. (1999) "Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells", Leukemia 13(5), 719-728.
- Cirandgirard, D., Studer, E., Monney, L., Belser, T., Fellay, I., Borner, C. and Michel, M.R. (1998) "Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated. proteolytic inactivation of Bcl-2", EMBO J. 17(5), 1268-1278.
- Widmann, C., Gibson, S. and Johnson, G.L. (1998) "Caspase-dependent cleavage of signaling proteins during apopiosis. A turn-off mechanism for anti-apoptotic signals", J. Biol. Chem. 273(12), 7141-7147.
- Kirsch, D.G., Doself, A., Chau, B.N., Lim, D.S., deSouza-Pinto, N.C., Hansford, R., Kastan, M.B., Uzebnik, Y.A. and Hardwick, J.M. (1999) "Caspase-3-dependent cleavage of Bcl-2 promotes release of cytocnrome t", J. Biol. Chem. 274(30), 21155-21161.
- Liang, Y., Nylander, K.D., Van, C. and Scher, N.F. (2002) "RoIe of caspase 3-dependent Bcl-2 cleavage in potentiation of apoplosis by Bcl-2", Mol. Pharmacil. 61(1), 142-149.
- Wasserman, R., GaIiIi, N., Ito, Y., Silber, J.H., Reichard, B.A., Shane, S., Womer, R.B., Lange, B. and Rovera, G. (1992) "Residual disease at the end of induction therapy as a predictor of relapse during therapy in childhood B-lineage acute lymphoblastic leukemia`", J. Clin. Oncol. 10(12), 1879-1888.
- Mudry, R.E., Fortney, J.E., York, T., Hall, B.M. and Gibson, L.F. (2000) "Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy`", Blood 96(5), 1926-1932.
- Fortney, J.H., Zhao, W., Wenger, S.L. and Gibson, L.P. (2001) "Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy", Leuk. Res. 25(10), 901-907.
- Gibson, L.F., Fortney, J., Landreth, K.S., Piktel, D., Ericson, S.G. and Lynch, J.P. (1997) "Disruption of bone marrow stromal cell function by etoposide`", BioI Blood Marrow Transplant. 3(3), 122-132.
- Herzig, R.H., Lynch, J., Curistiansen, N.P., Fay, J.W., Davis, M.P. and Herzig, G.P. (1996) "Dose-intensive chemotherapy with eloposide-cyclophosphamide for advanced breast cancer. North American Marrow Transplant Group", Semin. Oncol. 23(2 Suppl. 4), 28-32.
- Laemmli, U.K. (1970) "Cleavage of structural proteins during the assembly of the head of bacteriophage T4", Nature 227(259), 680-685.
- Gurtu, V., Kaki, S.R. and Zhang, O. (1997) "Fluorometric and colorimetric detection of caspase activity associated with apoplosis", Anal. Biochem. 251(1), 98-102.
- Manabe, A., Muni, K.G., Coustan-Smith, E., Kurnangi, M., Behra, F.G., Raimondi, R.C. and Campana, M. (1994) "Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells", Blood 83(3), 758-766.
- Campana, D., Manabe, A. and Evans, W.E. (1993) "Stroma-supported immunocytometric assay (SlA): a novel method for testing the sensitivity of acute lymphoblastic leukemia cells to cytotoxic drugs", Leukemia 7(3), 482-488.
- Manabe, A., Coostan-Smith, E., Kumagai, M., Behm, F.G., Raimondi, S.C., Pui, C.H. and Campana, D. (1994) "Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia", Blood 83(7), 1731-1737.
- Kumagai, M., Coustan-Smith, E., Murray, D.J., Silvennoinen, O., Muni, K.G., Evans, W.E., Malvasi, K and Campana, D. (1995) "Ligation of CD38 suppresses human B lymphopoiesis", J. Exp. Med. 181(3), 1101-1110.
- Kumagai. M., Manabe, A., Pui, C.H., Behm, F.G., Raimondi, S.C., Hancock, M.L., Mashmoud, H., Crist, W.M. and Campana, D. (1996) "Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome", J. Clin, Invest. 97(3), 755-760.
- Ashley, D.M., Bol, S.J. and Kannourakis, G. (1995) "Viable bone marrow stromal cells are required for the in film survival of B-cell precursor acute lymphoblastic leukcmic cells", Leuk. Res. 19(2), 113-120.
- Lagneaux, L., Delforge, A., Broil, D., De Bruyn, C. and Stryckmans, P. (1998) "Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells`", Blood 91(7), 2387-2396.
- Panayiotidis, P., Jones, D., Ganeshaguru, K., Foroni, L. and Horffbrand, A. V. (1996) "Human bone marrow stromal cells prevent apoplosis and support the survival of chronic lymphocytic leukaemia cells in vitro", Br. J. Haematol. 92(1), 97-103.
- Murti, K.G., Brown, P.S., Kumagai, M. and Campana, D. (1996) "Molecular interactions between human B-cell progenitors and the bone marrow microenvironment", Exp. Cell. Res. 226(1), 47-58.
- Gibson, L.F., Piktel, D., Narayanan, R., Nuoez, G. and Landreth, K.S. (1996) "Stromal cells regulate bcl-2 and bax expression in pro-B cells", Exp. Hematol. 24(5), 628-637.
- Hall, B.M., Fortney, J.E and Gibsou, L.F. (2001) "Alteration of nuclear factor-kappaB (NF-kappaB) expression in bone marrow stromal cells treated with etoposide", Biochem. Pharmacol. 61(10), 1243-1252.
- Del BeIIo, B., Valentini, M.A., Zunino, F., Comporti, M. and Maellaro, E. (2001) "Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoplosis of human melanoma cells`", Oncogene 20(33), 4591-4595.
- Beale, P.J., Rogers, P., Boxall, F., Sharp, S.Y. and Kelland, L.R. (2000) "Bcl-2 family protein expression and platinum drug resistance in ovarian carcinoma`", Br. J. Cancer 82(2), 436-440.
- Mudry, R., Fortney, J., York, T., Hall, B and Gibson, L.F. (2000) "Stromal cells regulate survival of JM-1 leukemic cells during chemotherapy", Bhood (96), 1-8.
Chemotherapy Induces Bcl-2 Cleavage in Lymphoid Leukemic Cell Lines
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.