Advanced search
Publication Cover
Leukemia & Lymphoma Volume 43, 2002 - Issue 12
Submit an article Journal homepage
59
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Alternation of Epirubicin and Mitoxantrone in CHOP-like Regimens Retains Efficacy and Reduces Overall Toxicity in Elderly Patients with High and Intermediate Grade Non-Hodgkin Lymphomas

Giuseppe Milone Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
,
Francesco Di Raimondo Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
,
Felicina Li Gioi Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
,
Giuseppe A. Palumbo Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
,
Giovanna Oriella Manenti Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
,
Marzia Pafumi Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
&
Rosario Giustolisi Chair and Division of Hematology, University of Catania Medical School, Ospedale Ferrarotto, Via S. Citelli 6, 95100 Catania, Italy
 show all
Pages 2319-2324 | Published online: 01 Jul 2009

  • O'Reilly, S., Klimo, R and Connors, J.M. (1991) "Low doses, ACOP-B and VABE: weekly chemotherapy for elderly patients with advanced-stage diffuse large cell lymphoma", J. Clin. Oncol. 9. 741-747.
  • Armitage, J.O. and Potter, J.F. (1934) "Aggressive chemotherapy for diffuse histiocytic lymphoma in the elderly". J. Am. Geriur. Soc. 32, 269-273.
  • Sonneveld, P., de Ridden, M., van der Lelie, H., Nieuwenhuis, K., Schaten, H., Mulder, A., van Reijswoud, I., Hop. W. and Lowenberg, B. (1995) "Comparison of doxorubiein and mitoxantrone in the treatment of elderly patients with advanced diffuse nonHodgkin's lyinphoma using CHOP versus CNOP chemotherapy". J. Clin. Oncol. 113, 2530-2539.
  • Brusamolino, E., Bertini, M., Guidi, S., Vitolo, U., Inverardi, U., Merante, S., Colombo, A., Resegotti, L. Bernasconi, C., Rossi Penrrini, P.L., Cametti, G, and Canta, M. (1988) "CHOP versus CNOP (N = Mitoxantrone) in non Hodgkin's lymphoma: an interim report comparing efficacy and toxicity", Haematologica 73, 217-122.
  • Bezwoda, W,. Rastogi, R.B., Erazo Valla, A., Diaz-Maqueo, J.C., Pavlovsky, S., Morioka, H., Resegotti, L., Rueckle, H., Somoza, N. and Moreno-Nogucira, J.A. (1995) "Long term results of a multicenter randomised comparative phase III that of CHOP versus CNOP in patients with intermediate and high grade non-Hodgkin's Lymphoma. Novantrone International Study Group", Eur J, Cancer 31, 903-911.
  • Lambertenghi-Delifiers, G. Butti, C., Baldini, L., Certani, A., Lombardi, F., Luani, M., Montalberti, L., Pavia, G., Pinotti, G., Pogliani, E, and Vanoli, P. (1995) "A cooperative study of Epirubien with Cyclophosphamide. Vineristine and prednisone (CEOP) in non-Hodgkin's lymphoma", Haemotologica 80, 318-324.
  • Silver, R., Case, DC., Wheeler, R.H., Miller, T., Stein, R., Stuart, J., Peterson, B., Rivkin, S., Colomb, H., Costanzi, J., Ersley, A., Reisman, A. and Dugan, M. (1991) "Multicenter clinical trial of mitoxantrone in non-Hodgkin's lymphoma and Hodgkin's disease". J. Clin. Oncol. 9, 754-761.
  • Zinzani, P.L., Storti, S., Zaccaria, A., Moretti, L., Magagnoli, M., Pavone, E., Gentilini, P., Guardigni, L., Gobbi, M., Fattori, P.P., Falimi, B., Lauta, V.M., Bendandi, M., Gherliazoni, F., De Renzo, A., Zaja, p., Mazza, P., Volpe, E., Bocchia, M., Aitini, E.,Tabanelli, M., Leone, G. and Tura, S. (1999) "Elderly aggressive-histology non Hodgkin's lymphoma: first-line VNCOP-B regimen experience on 350 patients"'. Blood 94, 33-38.
  • O'Reilly, S.E., Connors, J.M., Howdle, S., Hoskins, P., Klasa, R., Klimo, P. and Stuart, D.S. (1993) "in search of an optimal regimen for elderly patients with advanced stage diffuse large cell lymphoma: results of a phase 11 study of P/DOCE chemotherapy". J. Clin. Oncol. 11, 2250-2257.
  • Martelli, M., Guglielmi, C., Coluzzi, S. Avvisati, G., Amadori, S., Giovanniai, M., Torromeo, C. and Mandelli, E (1993) "P-VABEC a prospective study of a new weekly chemotherapy regimen for elderly aggressive non-Hodgkin's lymhoma", J. Clin. Oncol, 11. 2362-2369.
  • Smith, P.J., Sykesm H.R., Fox, M.E. and Furlog, I.J. (1992) "Subcellular distribution of the anticancer drug mitoxantrone in human drug-resistant murine cells analysed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage". Cancer Res, 52, 4000-4008.
  • Cabanillas, F. (1990) "Mitoxantrone as montrtherapy versus combination therapy: a panel discussion". Semin. Oncol. 17(Suppl. 10). 41-43.
  • De Lena, M., Ditonno, P., Lorusso, V., Brandi, M., Timuriau, A., Marzullo, F., Ventrella, V. and Pellecchio, A. (1995) "CEOP-B alternated with VIMB in intermediate grade and high grade non-Hodgkin's lymphoma: a pilot study". J. CIin. Oncol. 13. 953-960.
  • National Cancer Institute sponsored study of classification of non-Hodgkin's Lymphomas: summary and description of a working formulation for clinical usage (1982) "The Non-Hodgkin's Lymphoma Pathologic Classification Project". Cancer 49. 2112-2135.
  • Carbone, P.P., Kaplan, U.S., Musshoff, K., Smithers, D.W. and Tubiana, M. (1971) "Report of the committee on Hodgkin's disease staging classifications", Cancer Res, 31. 1860- 1861.
  • Tirelli, U., Zagonel, V. Erranie, D., Serraino, D, Tolomini, R., De Cicco, M., Carbone, A. and Monfardini, S. (1992) "A prospective study of a new combination chemotherapy regimen in patients older than 70 years with unfavourable non-Hodgkin's lymphorna", J Clin. Oncol. 10, 228-236
  • Salvagno, L., Contu, A., Bianco, A., Endrizzi, L., Schintyu, G.M, OImeo, N., Aversa, S.M., Chiarion-Sileni, V., Sururu, M. and Fiorentino, M.V. (1992) "A combination of mitoxantrone, etoposide and prednisone in elderly patients with non-Hodgkin's lymphosma". Ann. Oncol. 10, 833-837
  • Bellesi, G. Rigacci, L., Alterini, R., Bernardi, E, Tefanacci, S., Innocentki, F., Fusco, I, Longo, G., Di LoIIo, S. and Rossi Ferrini. P.L. (1996) "A new protocol (MlCEP) for the treatment of intermediate or high-grade non-Hodgkin's lymphoma in the elderly". Leak. Lymphoma 20, 475-480.
  • Goss, P., Burkes, R., Rudinskas, L., King, M. Chow, W., Myers, B., Davidson, M., Puldre, P., Crump, M., Sutton, D. and Scott, G. (1915) "A phase II of prednisone, oral etoposide. and novantrone as initial treatment of non-Hodgkin's lymphoma in elderly patients", Leuk. Lymphoma 18, 145-152,
  • Bessell, E.M., Coutts, A., Eletcher, J., Togtrill, P.J., Moloney, A.J., Ellis, I.O., Hulman, G. and Jenkins, D. (1994) "Non-Hodgkin's Symphoma-in elderly patients: a phase Il study of MCOP chemotherapy in patients aged 70 years or over with intermediate or high-grade histology". Eur. J. Caancer 30, 1337-1341.
  • Falkson, G., Klein, B. and Falkson, H. (1985) "Hematological toxicity: experience with anthracyclines and anthracenes", Exp. Hematol, 13(Suppl. 16). 64-71
  • Gherlinzoni, E. Guglielmi, C., Mazza, P., Arnadon, S., Mandelli, F and Tura, S. (1990) "Phase III comparalive trial Im-BACOD y m-BNCOD) in the treatment of stage II-IV non-Hodgkin's Iymphomas with intermediate or high grade histology", Semin. Oncol, 17(6 Suppl. 10), 3-9.
  • Okunewick, P., Buffo, M.J. and Kociban, D.L. (1985) "Comparative toxicity of mitoxantrone and doxorubien on hematopoietic stem cells", Exp. Hematol. 13(Suppl. 16), 23-30.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.