Advanced search
Publication Cover
Leukemia & Lymphoma Volume 43, 2002 - Issue 1
Submit an article Journal homepage
28
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Current Management of Polycythemia Vera

Ayalew Tefferi Division of Hematology and Internal Medicine, West 10, Mayo Clinic, 200 First Street SW, Rochester MN 55905, USA
Pages 1-7 | Published online: 01 Jul 2009

  • Dameshek, W. (1951) "Some speculations on the myeloproliferative syndromes", Blood 6, 372-375, editorial.
  • Amamson, J.W., Fialkow, P. J., Murphy, s., Prach, J.F. and Steinmann, L. (1976) "Polycythemia vera: stem-cell and probable clonal origin of the disease", The New England Journal of Medicine 295, 913-916.
  • Ania, B.J., Suman, V.J., Sobell, J.L., Codd, M.B., Silverstein. M.N. and melton, III, L.J. (1994) "Trends in the incidence of polycythemia vera among Olmsted County Minnesota residents, 1935-1989", American Journal of Hematology 47, 89-93.
  • Gruppo Italiano Studio Policitemia (1995) "Polycythemia vera: the natural history of 1213 patients followed for 20 years", Annals of Internal Medicine 123, 656-664.
  • Rozman, C., Giralt, M., Feliu, E., Rubio, D. and Cortes, M.T. (1991) "Life expectancy of patients with chronic nonleukemic myeloproliferative disorders", Cancer 67, 2658-2663.
  • Berk, P.D., Wasserman, L.R., Fruchtman, S.M. and Goldberg, J.D. (1995) "Treatment of polycythemia vera: a summary of clinical trials conducted by the Polycythemia Vera Study Group", In: Wasserman, L. R., Berk, P. D. and Berlin, N.I., eds, Polycythemia Vera and the Myeloproliferative Disorders (WB Saunders, Philadelphia), pp 166-194.
  • Berlin, N.I. (1975) "Diagnosis and classification of the polycythemias", Seminars in Hematology 12, 339-351.
  • Zanjani, E.D., Lutton, J.D., Hoffman, R. and Wasserman, L.R. (1977) "Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin", The Journal of Clinical Investigation 59, 841-848.
  • Cotes, P. M., Dore, C.J., Yin, J.A., Lewis, S.M., Messinezy, M., Pearson, T. C. and Reid, C. (1986) "Determination of serum immunoreactive erythropoietion in the investigation of erythrocytosis", The New England Journal of Medicine 315, 283-287.
  • Pearson, T.C. and Messinezy, M. (1996) "he diagnostic criteria of polycthaemia rubra vera", Leukemia & Lymphoma 22 (Suppl. 1), 87-93.
  • Michiels, j.j. and Juvonen, E. (1997) "Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the Thrombocythemia Vera Study Group", Seminars in Thrombosis and Hemostasis 23, 339-347.
  • Moliterno, A. R., Hankins, W.D. and Spivak, J.L. (1998) "Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera", The New England Journal of Medicine 338, 572-580.
  • Tefferi, A., Yoon, S.Y. and Li, C.Y. (2000) "Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis", Blood 96, 771-772.
  • Tefferi, A. (1999) "Diagnosing polycythemia vera: a paradigm shift", Mayo Clinic Proceedings 74, 159-162.
  • Fairbanks, V.F. and Tefferi, A. (2000) "Normal ranges for packed cell volume and hemoglobin concentration in adults: relevance to apparent polycythemia" European Journal of Haematology 65, 285-296.
  • Carneskog, J., Kutti, J., Wadenvik, H., Lundberg, P.A. and Lindstedt, G. (1998) "Plasma erythropoietin by high-detectability immunoradiometric assay in untreated and treated patients with polycythaemia vera and essential thrombocythaemia", European Journal of Haematology 60, 278-282.
  • Birgegard, G. and Wide, L. (1992) "Serum erythropoientin in the diagnosis of polycythaemia and after phlebotomy treatment", British Journal of Haematology 81, 603-606.
  • Messinezy, M., Westwood, N.B., Woodcock, S.P., Strong, R.M. and Pearson, T. C. (1995) "Low serum erythropoietin--a strong diagnostic criterion of primary polycythaemia even at normal haemoglobin levels", Clinics in Laboratory haematology 17, 217-220.
  • Najean, Y., Schlageter, M.H., Toubert, M.E. and Podgorniak, M.P. (1990) "Radioimmunoassay of immunoreactive erythropoietin as a clinical tool for the classification of polycythaemias", Nouvelle Revue Francaise d'Hematologie (Paris) 32, 237-240.
  • Remacha, A.F., Montserrat, I., Santamaria, A., Oliver, A., Barcelo, M.J. and Parellada, M. (1997) "Serum erythropoientin in the diagnosis of polycythemia vera. A follow-up study", Haematologica 82, 406-410.
  • Shih, L.Y., Lee, C.T. and Ou, Y.C. (1997) "Prediction of clinical course in patients with idiopathic erythrocytosis by endogenous erythroid colony assay but not by serum erythropoietin levels", Experimental Hematology 25, 288-292.
  • Shih, L.Y. and Lee, C.T. (1994) "Identification of masked polycythemia vera from patients with idiopathic marked thrombocytosis by endogenous erythroid colony assay", Blood 83, 744-748.
  • Westwood, N.B. and Pearson, T.C. (1996) "Diagnostic applications of haemopoietic progenitor culture techniques in polycythaemias and thrombocythaemias", Leukemia & Lymphoma 22(Suppl. 10, 95-103.
  • Michiels, J.J., Koudstaal, P.J., Mulder, A.H. and van Vliet, H.H. (1993) "Transient neurologic and ocular manifestations in primary thrombocythemia", Neurology 43, 1107-1110.
  • Denman, S.T. (1986) "A review of pruritus", Journal of the American Academy of Dermatology 14, 375-392.
  • Bilgrami, S. and Greenberg, B.R. (1995) "Polycythemia rubra vera", Seminars in Oncology 22, 307-326.
  • Kaplan, M.E., Mack, K., Goldberg, J.D., Donovan, P.B. Berk, P.D. and Wasserman, L.R. (1986) "Long-term management of polycythemia vera with hydroxdyurea: a progress report", Seminars in Hematology 23, 167-171.
  • Vaquez, H. (1892) "Sur une forme spéciale de cyanose s' accompagnant d' hyperglobulie excessive et persistante", Le bulletin Médical (Paris) 6, 849.
  • Rosenthal, N. and Bassen, F.A. (1938) "Course of polycythemia", Archives of Internal Medicine 62, 903-917.
  • Lawrence, J.H., Berlin, N.I. and Huff, R.L. (1953) "The nature and treatment of polycythemia: studies on 263 patients", Medicine (Baltimore) 32, 323-388.
  • Chievitz, E. and Thiede, T. (1962) "Complications and causes of death in polycythaemia vera", Acta Medica Scandinavica 172, 513-523.
  • Fruchtman, S.M., Mack, K., Kaplan, M.E., Peterson, P., Berk, P.D. and Wasserman, L.R. (1997) "From efficacy to safety: a Polycythemia Vera Study Group report on hydroxyurea in patients with Polycythemia vera", Seminars in Hematology 34, 17-23.
  • Berk, P.D., Goldberg, J.D., Donovan, P.B., Fruchtman, S.M., Berlin, N.I. and Wasserman, L.R. (1986) "Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols", Seminars in Hematology 23, 132-143.
  • Thomas, D.J., du Boulay, G.H., Marshall, J., Pearson, T.C. Ross Russell, R. W., Symon, L., Wetherley-Mein, G. and Zilkha, E. (1977) "Cerebral blood-flow in polycythaemia", Lancet 2, 161-163.
  • Wade, J.P. (1983) "transport of oxygen to the brain in patients with elevated haematocrit values before and after venesection", Brain 106(Part 2), 513-523.
  • Pearson, T.C. anb Wetherley-Mein, G. (1978) "Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia", Lancet 2, 1219-1222.
  • Pearson, T.C. and Wetherley-Mein, G. (1979) "The course and complications of idiopathic erythrocytosis", Clinical and Laboratory Haematology 1,189-196.
  • Najean, Y. and Rain, J.D. (1997) "The very long-term evolution of polycythemia vera: an analysis of 318 patients initially treated by phlebotomy or 32P between 1969 and 1981", Seminars in Hematology 34, 6-16.
  • Berk, P.D., Goldberg, J.D., Silverstein, M.N. Weinfeld, A., Donovan, P.B., Ellis. J.T., Landaw, S.A., Laszlo, J., Najean, Y., Pisciotta, A.V. and Wasserman, L.R. (1981) "Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy", The New England Journal of Medicine 304, 441-447.
  • Najean, Y. and Rain, J.D. (1997) "treatment of polycythemia vera: the use of hydroxdyurea and pipobroman in 292 patients under the age of 65 years", Blood 90, 3370-3377.
  • Najean, Y. and Rain, J.D. (1997) "Treatment of polycythemia vera: use of 32P alone or in combination with maintenance therapy using hydroxyurea in 461 patients greater than 65 years of age. The French Polycythemia Study Group", Blood 89, 2319-2327.
  • Leukemia and Hematosarcoma Coopertive Group, European Organization for Research on Treatment of Cancer (EORTC)(1981) 'Treatment of polycythaemia vera by radiophosphorus or busulphan: a randomized trial", British Journal of Cancer 44, 75-80.
  • Donovan, P.B., Kaplan, M.E., Goldberg, J.D., Tatarsky, I., Najearn, Y., Silberstein, E.B., Knospe, W.H., Laszlo, J., Mack, K., Berk, P.D. and Wasserman, L.R. (1984) "Treatment of polycythemia vera with hydroxyurea", American Journal of Hematology 17, 329-334.
  • Tatarsky, I. and Sharon, R. (1997) "management of polycythemia vera with hydroxdyurea", Seminars in Hematology 34, 24-28.
  • West, W. O. (1987) "Hydroxyurea in the treatment of polycythemia vera: a prospective study of 100 patients over a 20-year period", Southern Medical Journal 80, 323-327.
  • Murphy, S., Peterson, P., Iland, H. and Laszlo, J. (1997) "Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment", Seminars in Hematology 34, 29-39.
  • Silver, R. T, (1997) "Interferon alfa: effects of long-term treatment for polycythemia vra", Seminars in Hematology 34, 40-50.
  • Elliott, M. A. and Tefferi, A. (1997) "Interferon-alpha therapy in polycythemia vera and essential thrombocythemia", Seminars in Thrombosis and hemostatis 23, 463-472.
  • Quesada, J.R., Talpaz, M., Rios, A., Kurzrock, R. and Gutterman, J.U. (1986) "Clinical toxicity of interferons in cancer patients: a review", Journal of Clinical Oncology 4, 234-243.
  • Sacchi, S., Leoni, P., Liberati, M., Riccardi, A., Tabilio, A., Tartoni, P., Messora, C., Vecchi, A., Bensi, L., Rupoli, S., Ucci, G., Falzetti, F., Grignani, F. and Martelli, M.F. (1994) "A prospective comparison between treatment with phelbotomy alone and with interferon-alpha in patients with polycythemia vera", Annals of Hematology 68, 247-250.
  • Taylor, P.C., Dolan, G., Ng, J.P., Paul, B., Collin, R. and Reilly, J.T. (1996) "Efficacy of recombinant interferon-alpha (rIFN-alpha) in polycythaemia vera: a study of 17 patients and an analysis of published data", British Journal of Haematology 92, 55-59.
  • Tang, S.S. and Frojmovic, M.M. (1980) "Inhibition of platelet function by antithrombotic agents which selectively inhibit low-Km cyclic 3',5'-adenosine monophosphate phosphodiesterase", The Journal of Laboratory and Clinical Medicine 95, 241-257.
  • Andes, W.A., Noveck, R.J. and Fleming, J.S. (1984) "Inhibition of platelet production induced by an antiplatelet drug, anagrelide, in normal volunteers", Thrombosis and Haemostasis 52, 325-328.
  • Gaver, R.C., Deeb, G., Pittman, K.A. and Smyth, R.D. (1981) "Disposition of anagrelide, an inhibitor of platelet aggregation", Clinical Pharmacology and Therapeutics 29, 381-386.
  • Spencer, C.M. and Brogden, R.N. (1994) "Anagrelide. A Review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of thrombocythaemia", Drugs 47, 809-822.
  • Gillespie, E. (1988) "Anagrelide: a potent an selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity", Biochemical Pharmacology 37, 2866-2868.
  • Balduini, C.L. Bertolino, G., Noris, P. and Ascari, E. (1992) "Effect of angagrelide on platelet count and function in patients with thrombocytosis and myeloproliferative disorders", Haematologica 77, 40-43.
  • Solberg, Jr., L.A., Tefferi, A., Oles, K.J., Tarach, J.S., Petitt, R.M., Forstrom, L.A. and Silverstein, M.N. (1997) "The effects of anagrelide on human megakaryocytopoiesis", British Journal of Haematology 99, 174-180.
  • Mazur, E.M., Rosmarin, A.G., Sohl, P.A., Newton, J.L. and Narendran, A. (1992) "Analysis of the mechanism of anagrelideinduced thrombocytopenia in humans", Blood 79, 1931-1937.
  • Silverstein, M.N., Petitt, R.M., Solberg, Jr., L.A., Fleming, J.S., Knight, R.C. and Schacter, L.P. (1988) "Anagrelide: a new drug for treating thrombocytosis", The New England Journal of Medicine 318, 1292-1294.
  • Anagrelide Study Group (1992) "Anagrelide, a therapy for thrombocythemic states: experience in 577 patients", The American Journal of Medicine 92, 69-76.
  • Mazzucconi, M.G., De Sanctis, V., Chistolini, A., Dragoni, F. and Mandelli, F. (1992) "Therapy with anagrelide in patients affected by essential thrombocythemia: preliminary results", Haematologica 77, 315-317.
  • Petitt, R.M., Silverstein, M.N. and Petrone, M.E. (1997) "Anagrelide for control of thrombocythemia in polycythemia and other myeloproliferative disorders", Seminars in Hematology 34, 51-54.
  • Tartaglia, A.P., Goldberg, J.D., Berk, P.D. and Wasserman, L.R. (1986) "Adverse effects fo antiaggregating platelet therapy in the treatment of polycythemia vera", Seminars in Hematology 23, 172-176.
  • Landolfi, R., Ciabattoni, G., Patrignani, P. and Castellana, M.A. (1992) "Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo", Blood 80, 1965-1971.
  • Rocca, B., Ciabattoni, G., Tartaglione, R., Cortelazzo, S., Barbui, T., Patrono, C. and Landolfi, R. (1995) "Increased thromboxane biosynthesis in essential thrombocythemia", Thrombosis and Haemostasis 74, 1225-1230.
  • Gruppo Italiano Studio Policitemia (GISP)(1997) "Low-dose aspirin in polycythaemia vera: a pilot study", British Journal of Haematology 97, 453-456.
  • Landolfi, R. and Marchioli, R. (1997) "European Collaboration on Low-dose Aspirin in Polycythemia vera (ECLAP): a randomized trial", Seminars in Thrombosis and Hemostasis 23, 473-478.
  • Budde, U., Schaefer, G., Mueller, N., Egli, H., Dent, J., Ruggeri, Z. and Zimmerman, T. (1984) "Acquired von Willebrand's disease in the myeloproliferative syndrome", Blood 64, 981-985.
  • Tefferi, A. (2001) "Chronic myeloproliferative diseases: polycythemia vera and agnogenic myeloid metaplasia", In: Tefferi, A., ed, Primary Hematology (Humana Press, Totowa. NJ), pp 137-147.
  • Tefferi, A., Solberg, Jr., L.A. and Silverstein, M.N. (2000) "A clinical update in polycythemia vera and essential thrombocythemia", The American Journal of Medicine 109, 141-149.
  • Tefferi, A. (2001) "Recent progress in the pathogenesis and management of essential thrombocythemia", Leukemia Research, 25, 369-377.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.