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Leukemia & Lymphoma Volume 45, 2004 - Issue 6
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Case Report

Simultaneous Appearance of Trisomy 8 and Trisomy 12 in Different Cell Populations in a Patient with Untreated B-Cell Chronic Lymphocytic Leukemia and Myelodysplasia

Hana Aviv Center for Human and Molecular Genetics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USACorrespondence[email protected]
,
Denga Tang Department of Pathology, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA
,
Kasturi Das Department of Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA
,
Jonathan S Harrison Center for Human and Molecular Genetics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA
,
Meera Hameed Department of Pathology, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA
&
Mala Varma Department of Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA
Pages 1279-1283 | Received 16 Oct 2003, Published online: 03 Aug 2009

Reference

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  • Maserati, E., Aprili, F., Vinante, F., Locatelli, F., Amendola, G., Zatterale, A., et al. (2002) "Trisomy 8 in myelodysplasia and acute leukemia is constitutional in 15-29% of cases", Genes, Chromo-somes and Cancer, 33, 93–97.
  • Andersen, M.K., Pedersen-Bjergaard, J., Kjeldsen, L., Dufva, I.H. and Brondum-Nielsen, K. (2002) "Clonal Ph negative hematopoi-esis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8", Leukemia, 16,1390— 1395.
  • Dierlamm, J., Michawc, L., Criel, A., Wlodarska, I., Van Den Berghe, H. and Hossfeld, D.K. (1997) "Genetic abnormalities in chronic lymphocytic leukemia and their clinical and prognostic implications", Cancer Genetics and Cytogenetics, 94, 27 — 35.

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