Advanced search
Publication Cover
Leukemia & Lymphoma Volume 45, 2004 - Issue 5
Submit an article Journal homepage
55
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Repeated Clonal Relapses in Classical Hodgkin's Lymphoma and the Occurrence of a Clonally Unrelated Diffuse Large B Cell Non-Hodgkin Lymphoma in the Same Patient

Roman K Thomas Molecular Tumor Biology and Tumor Immunology, Department I for Internal Medicine, University of Cologne, 50924, CologneCorrespondence[email protected]
,
Claudia Wickenhauser The Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne
,
Dieter Kube Institute of Pathology, University of Cologne, 50924, Cologne
,
Hans Tesch Department for Hematology and Oncology, Center for Internal Medicine, University of Göttingen, 37075, Göttingen
,
Volker Diehl Department I for Internal Medicine, University of Cologne, 50924, Cologne
,
Jürgen Wolf Department of Pediatrics I, Children's Hospital, University of Göttingen, 37075, Göttingen, Germany
&
Martina Vockerodt Molecular Tumor Biology and Tumor Immunology, Department I for Internal Medicine, University of Cologne, 50924, Cologne
 show all
Pages 1065-1069 | Received 03 Nov 2003, Published online: 03 Aug 2009

References

  • Kiippers, R. and Rajewsky, K. (1998) "The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease", Annual Review of Immunology, 16, 471–493.
  • Jaffe, E.S., Zarate-Osorno, A. and Medeiros, L.J. (1992) "The interrelationship of Hodgkin's disease and non-Hodgkin's lympho-mas—lessons learned from composite and sequential malignancies", Seminars in Diagnostic Pathology, 9, 297–303.
  • Kerl, K., Girardet, C. and Borisch, B. (1999) "A common B-cell precursor in composite lymphomas", New England Journal of Medicine, 341, 764–765.
  • Vockerodt, M., Soares, M., Kanzler, H., Kiippers, R., Kube, D., Hansmann, M.L., et al. (1998) "Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rear-ranged VH genes in different biopsies in relapsed Hodgkin's disease", Blood, 92, 2899–2907.
  • Kiippers, R., Zhao, M., Hansmann, M.L. and Rajewsky, K. (1993) "Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections", EMBO Journal, 12, 4955–4967.
  • Jox, A., Zander, T., Diehl, V. and Wolf, J. (1997) "Clonal relapse in Hodgkin's disease", New England Journal of Medicine, 337, 499.
  • Jox, A., Zander, T., Kornacker, M., Kanzler, H., Kuppers, R., Diehl, V., et al. (1998) "Detection of identical Hodgkin-Reed Sternberg cell specific immunoglobufin gene rearrangements in a patient with Hodgkin's disease of mixed cellularity subtype at primary diagnosis and in relapse two and a half years later", Annals of Oncology, 9, 283–287.
  • Rajewsky, K. (1996) "Clonal selection and learning in the antibody system", Nature, 381, 751–758.
  • Ohno, T., Smir, B.N., Weisenburger, D.D., Gascoyne, R.D., Hinrichs, S.D. and Chan, W.C. (1998) "Origin of the Hodgkin/ Reed-Sternberg cells in chronic lymphocytic leukemia with 'Hodg-kin's transformation", Blood, 91, 1757— 1761.
  • Bräuninger, A., Hansmann, M.L., Strickler, J.G., Dummer, R., Burg, G., Rajewsky, K., et al. (1999) "Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma", New England Journal of Medicine, 340, 1239–1247.
  • Kiippers, R., Sousa, A.B., Baur, AS., Strickler, J.G., Rajewsky, K. and Hansmann, M.L. (2001) "Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL", Molecular Medicine, 7, 285–292.
  • Bellan, C., Lazzi, S., Zazzi, M., Lalinga, A.V., Palummo, N., Galieni, P., et al. (2002) "Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?", Diagnostic Molecular Pathology, 11, 2–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.