75
Views
15
CrossRef citations to date
0
Altmetric
Original Article

WT1 Gene Transcript Assay for Relapse in Acute Leukemia after Transplantation

, , &
Pages 1747-1753 | Received 21 Feb 2004, Published online: 03 Aug 2009

References

  • Call, KM., Glaser, T., Ito, C.Y., Buckler, A.J., Pelletier, J., Haber, D.A., et al. (1990) "Isolation and characterization of a zinc finger polypeptide gene at human chromosome 11 Wilms' tumor locus", Cell, 60, 509–520.
  • Gessler, M., Poustka, A., Cavenee, W., Neve, R.L., Orkin, S.H. and Bruns, G.A. (1990) "Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping", Nature, 343, 774–778.
  • Rauscher, F.J. 3rd. (1993) "The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor", FASEB J., 7, 896–903.
  • Rose, E.A., Glaser, T., Jones, C., Smith, C.L., Lewis, W.H., Call, K.M., et al. (1990) "Complete physical map of the WAGR region of 1 1p13 localizes a candidate Wilms' tumor gene", Cell, 60, 495 — 508.
  • Inoue, K., Sugiyama, H., Ogawa, H., Nakagawa, M., Yamagami, T., Miwa, H., et al. (1994) "WTI as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia", Blood, 84, 3071–3079.
  • Inoue, K., Ogawa, H., Sonoda, Y., Kimura, T., Sakabe, H., Oka, Y., et al. (1997) "Aberrant overexpression of the Wilms tumor gene (WTI) in human leukemia", Blood, 89, 1405–1412.
  • Miwa, H., Beran, M. and Saunders, G.F. (1992) "Expression of the Wilms' tumor gene (WTI) in human leukemias", Leukemia, 6, 405 — 409.
  • Miyagi, T., Ahuja, H., Kubota, T., Kubonishi, I., Koeffler, H.P. and Miyoshi, I. (1993) "Expression of the candidate Wilms' tumor gene, WTI, in human leukemia cells", Leukemia, 7, 970–977.
  • Brieger, J., Weidmann, E., Fenchel, K., Mitrou, P.S., Hoelzer, D. and Bergmann, L. (1994) "The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells", Leukemia, 8, 2138 — 2143.
  • Menssen, H.D., Renkl, H.J., Rodeck, U., Maurer, J., Notter, M., Schwartz, S., et al. (1995) "Presence of Wilm's tumor gene (wt 1) transcripts and the WT1 nuclear protein in the majority of human acute leukemia", Leukemia, 9, 1060–1069.
  • Hosen, N., Sonoda, Y., Oji, Y., Kimura, T., Minamiguchi, H., Tamaki, H., et al. (2002) "Very low frequencies of human normal CD34 ± hematopoietic progenitor cells express the Wilms' tumor gene WTI at the levels comparable to those in leukemia cells", Br. J. Haematol., 116, 409–420.
  • Sykes, P.J., Neoh, S.H., Brisco, M.J., Hughes, E., Condon, J. and Morley, A.A. (1992) "Quantitation of targets for PCR by use of limiting dilution", Biotechniques, 13, 444–449.
  • Gilliland, G., Perrin, S., Blanchard, K. and Bunn, H.F. (1990) "Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction", Proc. Natl. Acad. Sci. U S A, 87, 2725–2729.
  • Kreuzer, K.A., Saborowski, A., Lupberger, J., Appelt, C., Na, I.K., le Coutre, P., et al. (2001) "Fluorescent 5'-exonuclease assay for the absolute quantification of Wilms' tumour gene (WT1) mRNA: implications for monitoring human leukaemias", Br. J. Haematol., 114, 313–318.
  • Siehl, J.M., Thiel, E., Leben, R., Reinwald, M., Knauf, W. and Menssen, H.D. (2002) "Quantitative real-time RT-PCR detects elevated Wilms tumor gene (WT1) expression in autologous blood stem cell preparations (PBSCs) from acute myeloid leukemia (AML) patients indicating contamination with leukemic blasts", Bone Marrow Transplant, 29, 379 — 381.
  • Cilloni, D., Gottardi, E., De Micheli, D., Serra, A., Volpe, G., Messa, F., et al. (2002) "Quantitative assessment of WT1 expression by real time quantitative PCR may be a usaful tool for monitoring minimal residual disease in acute leukemia patients", Leukemia, 16, 2115 — 2121.
  • Tamaki, H., Mishima, M., Kawakami, M., Tsuboi, A., Kim, E.H., Hosen, N., et al. (2003) "Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms' tumor gene (WT1)", Int. J. Hematol., 78, 349 — 356.
  • Suzuki, T., Higgins, P.J. and Crawford, D.R. (2000) "Control selection for RNA quantitation", Biotechniques, 29, 332— 337.
  • Lossos, IS., Czerwinski, D.K., Wechser, M.A. and Levy, R. (2003) "Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies", Leukemia, 17, 789–795.
  • Lion, T. (2001) "Debate round table on RT-PCR controls: concluding remarks and mini-review", Leukemia, 15, 1033— 1037.
  • Brieger, J., Weidmann, E., Maurer, U., Hoelzer, D., Mitrou, P.S. and Bergmann, L. (1995) "The Wilms' tumor gene is frequently expressed in acute myeloblastic leukemias and may provide a marker for residual blast cells detectable by PCR", Ann. Oncol., 6, 811–816.
  • Tamaki, H., Ogawa, H., Ohyashiki, K., Ohyashiki, J.H., Iwama, H., Inoue, K, et al. (1999) "The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes", Leukemia, 13, 393–399.
  • Greenberg, P., Cox, C., LeBeau, M.M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., et al. (1997) "International scoring system for evaluating prognosis in myelodysplastic syndromes", Blood, 89, 2079 — 2088.
  • Cilloni, D., Gottardi, E., Messa, F., Fava, M., Scaravaglio, P., Bertini, M., et al. (2003) "Piedmont Study Group on Myleodys-plastic Syndromes. Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes", J. Clin. Oncol., 21, 1988 — 1995.
  • Yamagami, T., Sugiyama, H., Inoue, K., Ogawa, H., Tatekawa, T., Hirata, M., et al. (1996) "Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis", Blood, 87, 2878 — 2884.
  • Inoue, K., Tamaki, H., Ogawa, H., Oka, Y., Soma, T., Tatekawa, T., et al. (1998) "Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells", Blood, 91, 2969 — 2976.
  • Oji, Y., Ogawa, H., Tamaki, H., Oka, Y., Tsuboi, A., Kim, E.H., et al. (1999) "Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth", Jpn. J. Cancer Res., 90, 194–204.
  • Oji, Y., Yamamoto, H., Nomura, M., Nakano, Y., Ikeba, A., Nakatsuka, S., et al. (2003) "Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma", Cancer Sci., 94, 712 — 717.
  • Silberstein, G.B., Van Horn, K., Strickland, P., Roberts, C.T. Jr. and Daniel, C.W. (1997) "Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer", Proc. Natl. Acad. Sci. USA, 94, 8132–8137.
  • Loeb, D.M. and Sukumar, S. (2002) "The role of WT1 in oncogenesis: tumor suppressor or oncogene?", Int. J. Hematol., 76, 117— 126.
  • Baird, P.N. and Simmons, PJ. (1997) "Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis", Exp. Hematol., 25, 312— 320.
  • Fraizer, G.C., Patmasiriwat, P., Zhang, X. and Saunders, G.F. (1995) "Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow", Blood, 86, 4704–4706.
  • Ogawa, H., Tamaki, H., Ikegame, K., Soma, T., Kawakami, M., Tsuboi, A., et al. (2003) "The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia", Blood, 101, 1698 — 1704.
  • Tamaki, H., Ogawa, H., Inoue, K., Soma, T., Yamagami, T., Miyake, S., et al. (1996) "Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia". Blood, 88, 4396–4398.
  • Schmid, D., Heinze, G., Linnerth, B., Tisljar, K., Kusec, R., Geissler, K., et al. (1997) "Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia", Leukemia, 11, 639–643.
  • Elmaagacli, A.H., Beelen, D.W., Trenschel, R. and Schaefer, U.W. (2000) "The detection of wt-1 transcripts is not associated with an increased leukemic relapse rate in patients with acute leukemia after allogeneic bone marrow transplantation or peripheral blood stem cell transplantation", Bone Marrow Transplant., 25, 91–96.
  • Inoue, K., Ogawa, H., Yamagami, T., Soma, T., Tani, Y., Tatekawa, T., et al. (1996) "Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms tumor gene) expression levels", Blood, 88, 2267 — 2278.
  • Bergmann, L., Miething, C., Maurer, U., Brieger, J., Karakas, T., Weidmann, E., et al. (1997) "High levels of Wilms' tumor gene (wtl) mRNA in acute myeloid leukemias are associated with a worse long-term outcome", Blood, 90,1217 — 1225.
  • Lin, F., van Rhee, F., Goldman, J.M. and Cross, N.C. (1996) "Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation", Blood, 87, 4473–4478.
  • Cilloni, D., Gottardi, E., Fava, M., Messa, F., Carturan, S., Busca, A., et al. (2003) "Usefulness of quantitative assessment of the WT1 gene transcript as a marker for minimal residual disease detection", Blood, 102, 773–774.
  • Carlens, S., Ringden, 0., Aschan, J., Hagglund, H., Ljungman, P., Mattsson, J., et al. (1998) "Risk factors in bone marrow transplant recipients with leukaemia. Increased relapse risk in patients treated with ciprofloxacin for gut decontamination", Clin. Transplant., 84–92.
  • Giralt, S.A. and Champlin, RE. (1994) "Leukemia relapse after allogeneic bone marrow transplantation: a review", Blood, 84, 3603— 3612.
  • Thomas, ED., Buckner, C.D., Banaji, M., Clift, R.A., Fefer, A., Flournoy, N., et al. (1977) "One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation", Blood, 49, 511— 533.
  • Kolb, H.J., Schattenberg, A., Goldman, J.M., Hertenstein, B., Jacobsen, N., Arcese, W., et al. (1995) "Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia", Blood, 86, 2041–2050.
  • Drobyski, W.R., Keever, CA., Roth, M.S., Koethe, S., Hanson, G., McFadden, P., et al. (1993) "Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose", Blood, 82, 2310–2318.
  • Porter, DL., Roth, M.S., McGarigle, C., Ferrara, J.L. and Antin, J.H. (1994) "Induction of graft-versus-host disease as immunother-apy for relapsed chronic myeloid leukemia", N. Engl. J. Med., 330, 100–106.
  • Collins, R.H. Jr., Shpilberg, 0., Drobyski, W.R., Porter, DL., Giralt, S., Champlin, R., et al. (1997) "Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation", J. Clin. Oncol., 15, 433–444.
  • Bader, P., Klingebiel, T., Schaudt, A., Theurer-Mainka, U., Handgretinger, R., Lang, P., et al. (1999) "Prevention of relapse in pediatric patients with acute leukemias and MDS after allogeneic SCT by early immunotherapy initiated on the basis of increasing mixed chimerism: a single center experience of 12 children", Leukemia, 13, 2079 — 2086.
  • Dazzi, F., Szydlo, R.M., Cross, N.C., Craddock, C., Kaeda, J., Kanfer, E., et al. (2000) "Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia", Blood, 96, 2712–2716.
  • Slavin, S., Naparstek, E., Nagler, A., Ackerstein, A., Samuel, S., Kapelushnik, J., et al. (1996) "Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation", Blood, 87, 2195–2204.
  • Ogawa, H., Tsuboi, A., Oji, Y., Tamaki, H., Soma, T., Inoue, K., et al. (1998) "Successful donor leukocyte transfusion at molecular relapse for a patient with acute myeloid leukemia who was treated with allogeneic bone marrow transplantation: importance of the monitoring of minimal residual disease by WT1 assay", Bone Marrow Transplant., 21, 525–527.
  • Weaver, C.H., Clift, R.A., Deeg, H.J., Storb, R., Appelbaum, FR., Bensinger, W., et al. (1994) "Effect of graft-versus-host disease prophylaxis on relapse in patients transplanted for acute myeloid leukemia", Bone Marrow Transplant., 14, 885–893.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.